CN110225774B - 药物递送设备 - Google Patents

药物递送设备 Download PDF

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Publication number
CN110225774B
CN110225774B CN201780083597.2A CN201780083597A CN110225774B CN 110225774 B CN110225774 B CN 110225774B CN 201780083597 A CN201780083597 A CN 201780083597A CN 110225774 B CN110225774 B CN 110225774B
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CN
China
Prior art keywords
hub
cartridge
housing
drug delivery
delivery device
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Expired - Fee Related
Application number
CN201780083597.2A
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English (en)
Chinese (zh)
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CN110225774A (zh
Inventor
T·考伊
C·韦伯
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Owen Mumford Ltd
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Owen Mumford Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2429—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
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    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
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    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A—HUMAN NECESSITIES
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    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features; Drive mechanisms or modes for piston rods
    • A61M5/31578—Constructional features; Drive mechanisms or modes for piston rods the piston rod being moved by the axial movement of a component directly in contact with it
    • A61M5/3158—Constructional features; Drive mechanisms or modes for piston rods the piston rod being moved by the axial movement of a component directly in contact with it the component being manually operated or triggered by an axially moving actuator operated by user, e.g. an axially movable injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A61M2005/247—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with fixed or steady piercing means, e.g. piercing under movement of ampoule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A61M2005/2474—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with movable piercing means, e.g. ampoule remains fixed or steady
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/206—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically with automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN201780083597.2A 2016-11-18 2017-11-17 药物递送设备 Expired - Fee Related CN110225774B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1619562.0A GB2556633A (en) 2016-11-18 2016-11-18 Medicament delivery device
GB1619562.0 2016-11-18
PCT/GB2017/053470 WO2018091917A1 (en) 2016-11-18 2017-11-17 Medicament delivery devices

Publications (2)

Publication Number Publication Date
CN110225774A CN110225774A (zh) 2019-09-10
CN110225774B true CN110225774B (zh) 2021-08-27

Family

ID=57993946

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780083597.2A Expired - Fee Related CN110225774B (zh) 2016-11-18 2017-11-17 药物递送设备

Country Status (8)

Country Link
US (1) US11717611B2 (enExample)
EP (1) EP3541456B1 (enExample)
JP (1) JP2020500592A (enExample)
KR (1) KR102491376B1 (enExample)
CN (1) CN110225774B (enExample)
GB (1) GB2556633A (enExample)
MX (1) MX2019005791A (enExample)
WO (1) WO2018091917A1 (enExample)

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EP2944340A1 (en) 2014-05-12 2015-11-18 Sanofi Activating mechanism for a medicament delivery device and medicament delivery device
US11033678B2 (en) * 2017-11-20 2021-06-15 Agist Medical Systems, Inc. Compact injector drive
US11040147B2 (en) 2017-11-21 2021-06-22 Acist Medical Systems, Inc. Injector position sensing
WO2022046600A1 (en) * 2020-08-26 2022-03-03 Eli Lilly And Company Medication delivery device including disposable and reusable portions
EP4243895A1 (en) * 2020-11-16 2023-09-20 West Pharmaceutical Services, Inc. Connection system for a drug delivery device
US20240033446A1 (en) * 2020-12-17 2024-02-01 Eli Lilly And Company Fluid delivery system with needle assembly
EP4744699A3 (en) * 2020-12-17 2026-08-05 Eli Lilly and Company Fluid delivery system with needle assembly
WO2024251793A1 (en) * 2023-06-05 2024-12-12 Sanofi Drug delivery device
EP4727624A1 (en) * 2023-06-19 2026-04-22 Eli Lilly and Company Needle assembly and fluid delivery system with needle assembly
CN121059946B (zh) * 2025-10-30 2026-06-16 北京理工大学 一种超高速射流深度可控的药物递送设备

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CN87105155A (zh) * 1986-07-01 1988-01-13 埃贝哈特·施吕特尔 自动注射器件及其药筒或安瓿
US5858001A (en) * 1995-12-11 1999-01-12 Elan Medical Technologies Limited Cartridge-based drug delivery device
US7556614B2 (en) * 2000-10-10 2009-07-07 Meridian Medical Technologies, Inc. Separation assembly for drug delivery device
WO2012152704A1 (en) * 2011-05-06 2012-11-15 Sanofi-Aventis Deutschland Gmbh Active valve for drug delivery
WO2013032841A1 (en) * 2011-08-29 2013-03-07 Sid Technologies Llc Subcutaneous and intradermal patch infusers
WO2014060563A2 (en) * 2012-10-17 2014-04-24 Oval Medical Technologies Limited Automatic drug delivery devices
CN104689467A (zh) * 2013-12-01 2015-06-10 贝克顿·迪金森公司 药剂装置
CN104984438A (zh) * 2010-05-20 2015-10-21 贝克顿·迪金森公司 药物传送装置
EP2944340A1 (en) * 2014-05-12 2015-11-18 Sanofi Activating mechanism for a medicament delivery device and medicament delivery device
WO2015197866A1 (en) * 2014-06-27 2015-12-30 Novo Nordisk A/S Autoinjector having needle shield triggering
WO2016028820A2 (en) * 2014-08-18 2016-02-25 Windgap Medical, Inc Portable drug mixing and delivery device and associated methods
CN105939742A (zh) * 2014-02-06 2016-09-14 诺和诺德股份有限公司 组合式药筒和针组件

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US6960192B1 (en) * 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
MX2012004681A (es) 2009-11-03 2012-06-14 Hoffmann La Roche Dispositivo para la aplicacion de medio liquido a bajo conteo de germenes.
EP2366634B1 (en) 2010-03-18 2014-11-05 Ardagh MP Group Netherlands B.V. Closure for an easy opening container and a container provided with such closure
MX2013007487A (es) * 2010-12-31 2013-08-15 Novo Nordisk As Dispositivo de inyeccion medico.
ES2686362T3 (es) * 2013-05-31 2018-10-17 3M Innovative Properties Company Aparato de inyección de microagujas que comprende una accionador inverso
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Publication number Priority date Publication date Assignee Title
CN87105155A (zh) * 1986-07-01 1988-01-13 埃贝哈特·施吕特尔 自动注射器件及其药筒或安瓿
US5858001A (en) * 1995-12-11 1999-01-12 Elan Medical Technologies Limited Cartridge-based drug delivery device
US7556614B2 (en) * 2000-10-10 2009-07-07 Meridian Medical Technologies, Inc. Separation assembly for drug delivery device
CN104984438A (zh) * 2010-05-20 2015-10-21 贝克顿·迪金森公司 药物传送装置
WO2012152704A1 (en) * 2011-05-06 2012-11-15 Sanofi-Aventis Deutschland Gmbh Active valve for drug delivery
WO2013032841A1 (en) * 2011-08-29 2013-03-07 Sid Technologies Llc Subcutaneous and intradermal patch infusers
WO2014060563A2 (en) * 2012-10-17 2014-04-24 Oval Medical Technologies Limited Automatic drug delivery devices
CN104689467A (zh) * 2013-12-01 2015-06-10 贝克顿·迪金森公司 药剂装置
CN105939742A (zh) * 2014-02-06 2016-09-14 诺和诺德股份有限公司 组合式药筒和针组件
EP2944340A1 (en) * 2014-05-12 2015-11-18 Sanofi Activating mechanism for a medicament delivery device and medicament delivery device
WO2015197866A1 (en) * 2014-06-27 2015-12-30 Novo Nordisk A/S Autoinjector having needle shield triggering
WO2016028820A2 (en) * 2014-08-18 2016-02-25 Windgap Medical, Inc Portable drug mixing and delivery device and associated methods

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Publication number Publication date
GB201619562D0 (en) 2017-01-04
EP3541456B1 (en) 2022-08-17
WO2018091917A1 (en) 2018-05-24
KR20190087486A (ko) 2019-07-24
US20190328973A1 (en) 2019-10-31
US11717611B2 (en) 2023-08-08
GB2556633A (en) 2018-06-06
JP2020500592A (ja) 2020-01-16
KR102491376B1 (ko) 2023-01-25
MX2019005791A (es) 2019-08-14
CN110225774A (zh) 2019-09-10
EP3541456A1 (en) 2019-09-25

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