CN1102054C - Medical wine (Kepitong) for treating rheumatoid arthritis - Google Patents

Abstract

The present invention relates to a rheumatoid arthritis treating medicinal wine prepared from traditional Chinese herbal medicines and white spirits through soaking preparation. The prescription of the traditional Chinese herbal medicines comprises Fibraurea tinctoria Lour, Sinomenium, Caulis Spatholobi, Fibraurea Recisa, Flos Daturae, Radix Aconiti, Epimedium Brevicornum, dew honeycomb, astragalus, Gentiana Macrophylla, Clematis Chinensis, Asarum Sieboldii, earthworm, Kusnezoff monkshood root, Glycyrrhiza Uralensis and white peony root. The medicinal wine can comprehensively adjust the immunological function of organisms and has the functions of removing toxins for detumescence, warming channels for dispelling coldness, dispelling wind, eliminating dampness, activating blood circulation to dissipate blood stasis, and treating both symptoms and root causes of diseases, and the effective rate for treating rheumatoid arthritis reaches more than 95%. The present invention also has obvious curative effects on rheumatic fever, ankylosing spondylitis, systemic lupus erythematosus, retrogression arthritis, hyperplastic spondylitis, behcet ' s disease, nephrotic syndromes, etc.

Description

The medicated wine of treatment rheumatoid arthritis

The present invention relates to a kind of medicated wine for the treatment of rheumatoid arthritis, particularly a kind of medicated wine that utilizes the treatment rheumatoid arthritis that Chinese herbal medicine soaking forms.

Rheumatoid arthritis be a kind of be the chronic general immunity disease of feature with the articular synovitis, with brothers refer to, the easiest the getting involved in little joint such as toe, outbreak repeatedly lastingly.Early stage redness and swelling of joints burning pain and dysfunction, late period is ankylosis or deformity then, even it is useless to disable.

Standard according to session June the 51st in 1987 revision of Americanism damp disease association has 4 persons in following 7, can be diagnosed as primary disease.1. at least 1 hour (〉=6 week) of deadlock morning.2.3 individual or 3 above arthroncuss (〉=6 week).3. joints of hand or metacarpophalangeal joints or near-end articulations digitorum manus swelling (〉=6 week).4. symmetrical swelling.5. the X line of hands changes.6. subcutaneous nodule.7. the rheumatoid factor positive.

Rheumatoid arthritis (RA) is a kind of very complicated disease, its pathogeny is many-sided, up to the present the cause of disease of RA is not also illustrated fully, and RA is to be feature with chronic synovitis, finally causes the autoimmune disease of cartilage absorption, osteoclasia and bone fibrosis.The characteristic of RA synovial membrane is changed into: synovial membrane type A cell propagation, and bone-marrow-derived lymphocyte, T lymphocyte and macrophages infiltration, polymorphonuclear cell is assembled and synovioblast propagation and fiber laydown.Wherein t cell activation is the core of inflammation.There is the scholar to think that the pathology of RA not only shows as the inflammation of synovium of joint, also relates to the blood supply and the microcirculation problem of the various tissues of joint part.Its pathologic basis is the deposition of immune complex in blood vessel wall, causes the RA vasculitis, can cause angiostenosis and thrombosis with vascular endothelial proliferation and swelling.RA patient nearly all exists II-III level microcirculation disturbance and blood viscosity to increase.RA belongs to traditional Chinese medical science arthromyodynia category, the RA pathogeny have inside and outside two because of.Endogenous cause of ill mainly contains innate deficiency, defends QI-insufficiency, or overworks, the healthy energy damage.Be that the said autoimmune function of modern medicine reduces.Exopathogenic factor mainly contains exopathogen invasion and attack bodies such as wind, cold, wet, heat, fights in QI and blood, must not declare logical, the multiple abscess joint.Therefore the primary disease deficient and excessive syndromes appearing together is intricate, forms vicious cycle, and its pain is delayed difficulty more to the bone.

Doctor trained in Western medicine is to the treatment of this disease, and mainly based on clinical symptomatic treatment, the medicine measure has, nonsteroidal anti-inflammatory agent and steroid immunosuppressant (as indometacin, prednisone, cyclophosphamide etc.).Above-mentioned measure is during treating, and symptom can have certain alleviation, but after the drug withdrawal, symptom reappears successively, often becomes a kind of incurable chronic disease.The traditional Chinese medical science is to the treatment of this disease, be conceived to expelling wind and removing dampness, collateral dredging cold expelling, concrete symptom adopts corresponding prescription, as indefinite to arthralgia, migration, joint stuffiness, with Ledebouriellae Decoction add and subtract that Radix Saposhnikoviae, Herba Ephedrae, Radix Angelicae Sinensis, Radix Gentianae Macrophyllae, Cortex Cinnamomi, Radix Puerariae, Fu make, Radix Glycyrrhizae, Rhizoma Zingiberis Recens etc.; To play of arthralgia, localized pain, pain alleviated while getting warmth, pain increase in intensity under coldness, joint unable to flex and stretch the extremities, with Aconiti Decoction add and subtract Aconitum carmichjaelii Debx., Herba Ephedrae, when medicine, Radix Glycyrrhizae, the Radix Astragali, Herba Asari, Ramulus Cinnamomi; To the joint weighing, pain or have that swelling, localized pain, inconvenient activity, numbness of the skin are meciless, tongue is greasy in vain, soft pulse, subtract Semen Coicis, Rhizoma Atractylodis, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Radix Aconiti, Herba Ephedrae, Ramulus Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Zingiberis Recens, Radix Glycyrrhizae etc. in order to Semen Coicis Tonga; Add and subtract Cortex erythrinae, Rhizoma Curcumae Longae, Radix Clematidis, Radix Saposhnikoviae, Ramulus Mori, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Ramulus Cinnamomi, Radix Glycyrrhizae, Caulis Lonicerae, Fructus Forsythiae, Cortex Phellodendri etc. to what arthralgia, local scorching hot redness, pain can not be touched, must coldly relax slightly with the white tiger guizhi decoction.The above each decoction is comparatively obvious in the curative effect of the disease of skin to the shallow visitor of disease, the disease in centering, late period but curative effect is not good enough, thereby to occur again chasing after the wind agent by force with Os Tigris, Os pardi and so on be the medicated wine that cures mainly compatibility of drugs, as tiger-bone medicated wine, leopard-bone wine etc., equally only be devoted to expelling wind and removing dampness, the symptom curative effect in centering, late period is not too remarkable.

Purpose of the present invention, be to provide a kind of with Chinese herbal medicine soaking, have the across-the-board regulation body's immunological function in mind, strengthen normal immune function, suppress the abnormal immune reaction and strengthen anti-inflammatory analgesic, the microcirculation improvement obstacle, thus reach treating both the principal and secondary aspects of a disease, the medicated wine of the treatment rheumatoid arthritis of strengthening vital QI to eliminate pathogenic factors, blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, collateral dredging cold expelling.

The present invention is by the following prescription celestial 8-10% root of Chinese wild ginger 1-4% earthworm 3-5% radix aconiti agrestis 4-6% Radix Glycyrrhizae 1-4% root of herbaceous peony 3-5% of formulated (consumption is weight percentage) herba fibraureae recisae 11.7-14% caulis sinomenii 11.7-14% reticulate millettia 10-13% herba aristolochiae 3-5% datura flower 3-5% monkshood 4-6% barrenwort 8-10% nidus vespae 1-2% Radix Astragali 10-13% bark of ash 10-13% spirit in proportion

Brewing method:

Above ten six medicaments are pulverized into smalls, place in the container, soaked 60 days, stir once weekly, take out after-filtration,, get product by every bottle of 250ML packing with 48 ° of Chinese liquor sealings.

Usage and consumption:

Oral meal, each 10-15ML, three times on the one, the child is cut down according to the circumstance or is followed the doctor's advice, and one month is a course of treatment, and light disease person takes a course of treatment, and serious symptom person takes three courses of treatment continuously.

Points for attention:

1. just use amount examination clothes less than normal, add to usual amounts gradually after waiting to adapt to the person.

2. this medicated wine property of medicine is comparatively high strong, and spleen and stomach function difference person generally may occur feeling sick, gastrointestinal reaction such as vomiting, stomachache and diarrhoea.

3. take the back if erythra occurs, anaphylaxis such as itch, answer drug withdrawal and give antiallergic and handle.

4. take for a long time and should make regular check on hemogram and the heart, liver, renal function.

5. severe cardiac, liver, kidney organic lesion and stomach, the careful usefulness of duodenum activeness ulcer person are arranged.

In the above-mentioned prescription, Caulis Fibraureae row twelve channels and collaterals has heat-clearing and toxic substances removing, expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation collateral dredging, reducing swelling and alleviating pain, the title of Chinese medicine " hormone " is arranged, synthesizing of energy inflammation-inhibiting medium prostaglandin, directly suppress lymphocyte, the generation of mononuclear cell and macrophage and division can also suppress cell and generate I ₀-II ₃, for suppressing the immunosuppressant of humoral immunoresponse(HI) indirectly.Caulis Sinomenii is in Compendium of Material Medica day: the genus of all tendrils, all can stimulate the menstrual flow into network, and the kind wind disease of controlling of this thing, so all severe and migratory arthralgia paralysis are all controlled it, infusing drugs in wine is wonderful especially.Modern study shows that its main effective ingredient is that sinoacutine has anti-inflammatory and antalgic, regulates immunization, in the performance analgesic activity, also by acting on the H on fibroblast surface ₂Receptor, control the hypertrophy of local joint pathological change and inhibition joint granulation tissue significantly, reach the effect of anti-inflammation detumescence, it also influences patient's immunologic function, make patient's cellular immunization rising itself and recover normal, and make the immune ball of unusual rising drop to normal range in vain, and it is normal that ESR recovers, and RF turns out cloudy.Herba Epimedii reinforcing the kidney and supporting YANG, strengthening the tendons and bones, expelling wind and removing dampness, be to establish at the primary disease innate deficiency cause of disease, the effect of androgen sample is arranged, the expansion peripheral blood vessel is arranged again, increase the acra blood flow, improve circulation and more comprehensive immune pharmacological action, with the promotion body's immunity, improve lipid metabolism, the effect of removing superoxides and free radical has obvious relation.Radix Astragali invigorating the spleen and replenishing QI benefit is supported the day after tomorrow, call at " Japan hanako materia medica ": the Radix Astragali helps the gas strengthening bone and muscle, put on flesh and enrich blood ... modern pharmacological research confirms that body nonspecific immunity humoral immunization, cellular immunization are all had tangible regulating action, promote the reticuloendothelial system phagocytic effect, improve immune status, increase the resistance of pernicious stimulation to external world.Radix Gentianae Macrophyllae expelling wind and removing dampness and muscle Shujin, clinical being referred to as " demulcen in the wind ", the someone thinks that Radix Gentianae Macrophyllae is longer than and nourishes blood, control wind and control blood earlier, the blood sector-style is from saying of going out, and modern medicine study proves that the effective ingredient gentianin increases with exciting PATH secretion by nervous system in the Radix Gentianae Macrophyllae.Caulis Spatholobi has blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates, belongs to the non-defective unit of controlling the wind arthralgia due to stagnation of blood, also is the key medicine of treatment amenorrhea, and the effect of antagonism Caulis Fibraureae reproduction poison is arranged.Flos Daturae analgesia collateral dredging reduces phlegm, and main component is a hyoscyamine, has the activation and the microcirculation improvement effect of pain relieving, spasmolytic, antiinflammatory, adjusting immunosuppressant complement system.Radix Aconiti, Radix Aconiti Kusnezoffii expelling wind and removing dampness, dispelling cold by warming the meridian have the narcotic analgesic effect, and " the Changsha medicine is separated " cloud: the Aconitum carmichjaelii Debx. warm-dryness syndrome is descending, and its property is dredged rapidly sharp, opens the pass natural fibre line of meat, and the power of expulsion cold-damp is very prompt, and all severe and migratory arthralgia all have good merit.Herba Aristolochiae is kind, and to control the stagnate pain effect of Rong Yinqi not of the muscles and bones stasis of blood obvious.Radix Clematidis wind-damp dispelling, the meridian dredging, expectorant saliva, according to " medicine justice ": Radix Clematidis, property are anxious suddenly, and lid is walked and do not kept, the logical twelve channels and collaterals of a surname.Herba Asari expelling pathogenic wind from the body surface, dispersing cold for relieving pain can be controlled hundred joint contractures, and rheumatic arthralgia is cold to disperse yin channel, search to pick rheumatism of muscles and bones and make it to go out and pain relieving.Pheretima is for going into the non-defective unit of network, can promoting blood circulation, sharp joint, repercussive stagnate, treat arthralgia pain, and draw all medicines and reach disease institute.Be aided with Nidus Vespae and strengthen the effect of dispelling wind and removing obstruction in the collateral analgesic, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription share sour and sweet drugs can transforme into YIN with the Radix Paeoniae Alba, yin nourishing hemorrhage, slow utmost point pain relieving.With wine a surname efficacy of a drug of loosing, the capable network that stimulates the menstrual flow is invigorated blood circulation and is transferred battalion, on scurry the top, mountain peak, reach myocutaneous junction, site where the skin and muscle are joined outward, the bypass extremity are guide.Strengthening vital QI to eliminate pathogenic factors is played, removing toxic substances and promoting subsidence of swelling, dispelling cold by warming the meridian, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, expectorant pain relieving, the merit for the treatment of both the principal and secondary aspects of a disease altogether by full side.

The present invention has as above advantage: this medicated wine adopts pure Chinese herbal medicine and wine infusion to form, and utilizes the comprehensive function treatment rheumatoid arthritis of each herbal medicine, and is nontoxic to human body, need not decoct taking convenience, energy across-the-board regulation body's immunological function, the microcirculation improvement obstacle, removing toxic substances and promoting subsidence of swelling, dispelling cold by warming the meridian, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, the expectorant pain relieving, treating both the principal and secondary aspects of a disease, the treatment effective percentage reaches more than 95%.

For showing the curative effect of this medicine to the treatment rheumatoid arthritis, the present invention carries out clinical observation through 632 routine patients, and its clinical data is as follows:

1. physical data: in 632 routine rheumatoid arthritiss, out-patient's 610 examples, inpatient 22 examples; Male's 156 examples, women's 476 examples; Between the age of onset 16 years old to 77 years old, wherein saw at most to 50 years old, account for 75% with 25 years old; The course of disease 1 year is with interior 30 examples, 1 to 5 year 158 example, 6 to 10 years 22 examples, 11 to 15 years 176 examples, 56 examples more than 16 years, wherein the longest 36 years, the shortest 59 days. all accepted the distinct methods treatment before the patient treatment, wherein steroid (meticorten, dexamethasone etc.) is taken or injected to 177 examples, 160 examples were taken nonsteroidal anti-inflammatory agent (indometacin, ibuprofen etc.), 152 examples were taken preparations such as Chinese medicine and externally applied ointment, and 74 examples were taken immunosuppressant or golden preparation (cyclophosphamide, Ruide etc.), and said medicine was used in 69 example mixing.

2. efficacy assessment standard: 1. cure: clinical symptom disappearance, functional activity are all normal, and the physico-chemical examination result is normal.2. effective: symptomatology or cardinal symptom are eliminated, and function of joint is recovered normally substantially, can participate in normal work and work.3. invalid: after adopting medicated wine treatment of the present invention, symptom and sign and laboratory indexes do not have obvious improvement.

3. therapeutic outcome: 498 examples are cured in above-mentioned criterion, effective 124 examples, and invalid 10 examples, above therapeutic outcome is short term effect (refer to 1 to 5 year with interior judgement), and late result refers to visit judgement after 5 years, total effective rate 98.4%.

4. efficacy analysis: medicated wine of the present invention is taken by above-mentioned instructions of taking and was come into effect in general 3 to 7 days, taking swelled and ache in 2 weeks obviously alleviates, the basic disappearance of swelling and ache in 4 weeks of taking medicine, and joint movement function obviously improves, take medicine and to locate steady statue in 3 months, the general nothing recurrence in the back of stopping using.Withdraw any antirheumatic (comprise hormones, remove as dependent tapering off property and stop) in the treatment phase.From experimental index, anemia, erythrocyte sedimentation rate, c reactive protein, rheumatoid factor are all had clear improvement.Erythrocyte sedimentation rate increases piece person, 1 week of taking medicine promptly begins obvious decline, can reach normal mostly after taking for 4 weeks, treats the rheumatoid factor negative conversion rate through 3 months to half a year and reaches 88.6%.The enlargement of hyperpyrexia (〉=39.5 ℃) companion arthralgia is all arranged in 10 routine invalid patients, and numeration of leukocyte obviously increases and anti-" 0 " titre strong positive person improves not obviously, can suitably cooperate antibiotic or take the heat-clearing and detoxifying herb treatment.

5. model case:

Chen Jinbao, woman, 51 years old, Daye City, Hubei Province copper record mountain cadre of food company.

The readme extremities joint is migration, and progressivity swells and ache year surplus in the of 30, increases the weight of gradually, once goes to a doctor in how tame section hospital.Be diagnosed as: rheumatoid arthritis.Adopt Drug therapys such as Chinese medicine and prednisone, side effect is big, has little effect and therapy discontinued, and the patient was in first visit on May 28 in 1997.Disease is seen: chronic painful hormone face, two metacarpophalangeal joints and wrist, toes sole of the foot joint symmetry swell and ache, distortion, joint stuffiness, function limitation, finger deadlock in morning (＞lh), silent, the white and thin fur of lustreless complexion, light red tongue, deep,thready and forceless pulse.Lab testing: RF (+), ESR108mm/h CRP55ug/ml ASO 〉=500 ^u, X-ray film: both hands refer to, in, metacarpophalangeal joints and the little soft tissue of joint swelling of near-end, the joint space narrows down.With medicated wine oral medication of the present invention, swelling and ache after 2 weeks of taking medicine alleviates, and action is flexible, stiff improvement in morning, and spiritual amelioration continued to take 1 month, swelled only to disappear pain, and every inspection recovers normally, and in order to consolidate curative effect, the patient still keeps former side and adhered to taking 3 months.On May 18th, 2000 visited, and asked for sick leave and did not more see recurrence.

Provide two embodiment of the present invention below.

Embodiment 1: Caulis Fibraureae 12% Caulis Sinomenii 12% Caulis Spatholobi 10% Herba Aristolochiae 4% Flos Daturae 4% Radix Aconiti 5% Herba Epimedii 9% Nidus Vespae 1% Radix Astragali 10% Radix Gentianae Macrophyllae 10% Radix Clematidis 8% Herba Asari 3% Pheretima 3% Radix Aconiti Kusnezoffii 5% Radix Glycyrrhizae 1% Radix Paeoniae Alba 3%

Embodiment 2: Caulis Fibraureae 12% Caulis Sinomenii 12% Caulis Spatholobi 10% Herba Aristolochiae 4% Flos Daturae 3% Radix Aconiti 6% Herba Epimedii 8% Nidus Vespae 2% Radix Astragali 10% Radix Gentianae Macrophyllae 10% Radix Clematidis 8% Herba Asari 3% Pheretima 3% Radix Aconiti Kusnezoffii 5% Radix Glycyrrhizae 1% Radix Paeoniae Alba 3%

Above-mentioned two embodiment by aforesaid brewing method infusion, are finished product after the bottling.

Claims (1)

1. a medicinal liquor for the treatment of rheumatoid arthritis is characterized in that it is the celestial 8-10% root of Chinese wild ginger 1-4% earthworm 3-5% radix aconiti agrestis 4-6% Radix Glycyrrhizae 1-4% root of herbaceous peony 3-5% of herba fibraureae recisae 11.7-14% caulis sinomenii 11.7-14% reticulate millettia 10-13% herba aristolochiae 3-5% datura flower 3-5% monkshood 4-6% barrenwort 8-10% nidus vespae 1-2% Radix Astragali 10-13% bark of ash 10-13% spirit that is made by the material medicine of following weight proportioning.