CN110198959B - 释放一氧化氮的海藻酸盐作为可生物降解抗菌支架和相关方法 - Google Patents
释放一氧化氮的海藻酸盐作为可生物降解抗菌支架和相关方法 Download PDFInfo
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- CN110198959B CN110198959B CN201880007216.7A CN201880007216A CN110198959B CN 110198959 B CN110198959 B CN 110198959B CN 201880007216 A CN201880007216 A CN 201880007216A CN 110198959 B CN110198959 B CN 110198959B
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- alginate
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- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762441742P | 2017-01-03 | 2017-01-03 | |
| US62/441,742 | 2017-01-03 | ||
| US201762483505P | 2017-04-10 | 2017-04-10 | |
| US62/483,505 | 2017-04-10 | ||
| PCT/IB2018/050051 WO2018127819A1 (en) | 2017-01-03 | 2018-01-03 | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110198959A CN110198959A (zh) | 2019-09-03 |
| CN110198959B true CN110198959B (zh) | 2023-03-28 |
Family
ID=62790817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880007216.7A Active CN110198959B (zh) | 2017-01-03 | 2018-01-03 | 释放一氧化氮的海藻酸盐作为可生物降解抗菌支架和相关方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11072668B2 (https=) |
| EP (1) | EP3565848A4 (https=) |
| JP (1) | JP7366406B2 (https=) |
| CN (1) | CN110198959B (https=) |
| AU (2) | AU2018205823A1 (https=) |
| CA (1) | CA3048785A1 (https=) |
| WO (1) | WO2018127819A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018067838A1 (en) | 2016-10-07 | 2018-04-12 | The University Of North Carolina At Chapel Hill | S-nitrosothiol-mediated hyperbranched polyesters |
| WO2018127819A1 (en) | 2017-01-03 | 2018-07-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
| JP7403152B2 (ja) | 2017-03-28 | 2023-12-22 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景 |
| EP3710514B1 (en) | 2017-11-15 | 2023-06-07 | The University of North Carolina at Chapel Hill | Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto |
| CA3091458A1 (en) | 2018-03-06 | 2019-09-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto |
| KR102041246B1 (ko) * | 2018-12-21 | 2019-11-06 | 국립암센터 | 양쪽이온성 알긴산 유도체 및 이를 포함하는 조영제 조성물 |
| CN113383019B (zh) * | 2018-12-28 | 2023-11-17 | 北卡罗来纳大学教堂山分校 | 一氧化氮释放型抗菌聚合物和由其制成的支架和其相关方法 |
| KR102203403B1 (ko) * | 2019-04-10 | 2021-01-15 | 주식회사 아이코어바이오 | 신규한 구조를 가지는 고분자, 이의 제조 방법, 고분자로부터 합성된 나노섬유 및 이의 제조 방법 |
| EP4093205A4 (en) * | 2020-02-07 | 2024-02-21 | KNOW Bio, LLC | Nitric oxide-releasing antibacterial compounds, formulations, and methods pertaining thereto |
| CN111410754B (zh) * | 2020-03-30 | 2021-06-25 | 暨南大学 | 一种s-亚硝基硫醇/多糖基原位成型水凝胶及其制备方法与应用 |
| GB202007928D0 (en) * | 2020-05-27 | 2020-07-08 | Attgeno Ab | New uses and methods |
| CN114652743B (zh) * | 2022-03-23 | 2024-10-15 | 南京师范大学 | 一种基于海藻酸钠的一氧化氮供体及其合成方法和应用 |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4169079A (en) | 1977-10-24 | 1979-09-25 | Iwao Tabushi | Polystyrene based polymers containing cyclodextrin derivatives, metal complexes of the same, and process for the production of the same |
| US5574027A (en) | 1989-11-22 | 1996-11-12 | Bernstein; Lawrence R. | Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones |
| US5234933A (en) | 1991-10-31 | 1993-08-10 | Board Of Governors Of Wayne State University And Vanderbilt University | Cyclic hydroxamic acids |
| DE4210332C1 (https=) | 1992-03-30 | 1993-07-15 | Gruenenthal Gmbh, 5100 Aachen, De | |
| US5814666A (en) | 1992-04-13 | 1998-09-29 | The United States As Represented By The Department Of Health And Human Services | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
| US5238832A (en) | 1992-06-08 | 1993-08-24 | Board Of Governors Of Wayne State University | Aryl aliphatic acids |
| US5910316A (en) | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
| US5405919A (en) | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
| US6200558B1 (en) | 1993-09-14 | 2001-03-13 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5650447A (en) | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
| US5525357A (en) | 1992-08-24 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5632981A (en) | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5691423A (en) | 1992-08-24 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-bound nitric oxide-nucleophile adducts |
| AU685178B2 (en) | 1993-10-08 | 1998-01-15 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers |
| US5840759A (en) | 1993-10-08 | 1998-11-24 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents |
| ATE192922T1 (de) | 1993-11-02 | 2000-06-15 | Us Health | Verwendung von stickstoffoxid freisetzenden verbindungen zur herstellung eines arzneimittels zum schutz gegen die ischämischen reperfusionsschäden |
| CH686873A5 (fr) | 1993-12-09 | 1996-07-31 | Lambert Jean Claude | Assortiment de jeux comportant chacun une planche de jeu et une série de pions. |
| CA2205564C (en) | 1994-11-22 | 2006-07-11 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pharmaceutical compositions comprising nitric oxide-releasing biopolymers |
| US5714511A (en) | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
| US6232434B1 (en) | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US5770645A (en) | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US20030093143A1 (en) | 1999-03-01 | 2003-05-15 | Yiju Zhao | Medical device having surface depressions containing nitric oxide releasing compound |
| JP4285775B2 (ja) | 1996-09-27 | 2009-06-24 | アメリカ合衆国 | O▲上2▼―アリール化またはo▲上2▼―グリコシル化1―置換ジアゼン―1―イウム―1,2―ジオレート類およびo▲上2▼―置換1―[(2―カルボキシラト)ピロリジン―1―イル]ジアゼン―1―イウム―1,2―ジオレート類 |
| EP2292630B1 (en) | 1996-09-27 | 2015-11-25 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | O2-substituted 1- (2-carboxylato)pyrrolidin-1-yl diazen-1-ium-1,2-diolates |
| NO305033B1 (no) | 1997-05-09 | 1999-03-22 | Algipharma As | Fremgangsmate for fremstilling av uronsyreblokker fra alginat |
| US6180082B1 (en) | 1997-11-24 | 2001-01-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method to enhance tissue accumulation of radiolabeled compounds |
| US6207855B1 (en) | 1998-06-23 | 2001-03-27 | Duke University Medical Center | Stable no-delivering compounds |
| US6261594B1 (en) | 1998-11-25 | 2001-07-17 | The University Of Akron | Chitosan-based nitric oxide donor compositions |
| JP4870314B2 (ja) | 2000-05-02 | 2012-02-08 | セラヴァンス, インコーポレーテッド | シクロデキストリンを含むグリコペプチド抗生物質組成物 |
| JP2002179647A (ja) | 2000-12-11 | 2002-06-26 | Kikkoman Corp | ニコチアナミン又はニコチアナミン含有物の製造法 |
| AUPR879601A0 (en) | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
| DE60302454T2 (de) | 2002-04-19 | 2006-08-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Beta-agonisten-verbindungen mit stickoxid-donatoren-gruppen und reaktionsfähige sauerstoffspezies-fängergruppen und ihre verwendung bei der behandlung von atemwegsstörungen |
| US20040038947A1 (en) | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| NO335366B1 (no) | 2002-07-26 | 2014-12-01 | Algipharma As | Mutantstamme Pf201 av Pseudomonas fluorescens og anvendelse derav i alginatproduksjon,samt fremgangsmåte for fremstilling derav. |
| NO20023581D0 (no) | 2002-07-26 | 2002-07-26 | Fmc Biopolymer As | Nye mutantstammer av Pseudomonas fluorescens og varianter derav, metoder for produksjon og bruk derav til produksjon avalginat |
| BRPI0314042B8 (pt) | 2002-09-06 | 2021-05-25 | Calando Pharmaceuticals Inc | polímeros à base de ciclodextrina para o fornecimento de agentes terapêuticos ligados a eles por covalência |
| US20050009789A1 (en) | 2003-05-13 | 2005-01-13 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Service | Cyclooxygenase inhibition with nitroxyl |
| JP2005047979A (ja) | 2003-07-30 | 2005-02-24 | Dainippon Ink & Chem Inc | 多分岐ポリマーの製造方法、及び多分岐ポリマー |
| SG113562A1 (en) | 2004-01-12 | 2005-08-29 | Agency Science Tech & Res | Polyalkyleneimine-graft-biodegradable polymers for delivery of bioactive agents |
| CN101151037A (zh) | 2005-01-28 | 2008-03-26 | 平纳克尔医药股份有限公司 | 作为抗菌剂的β-环糊精衍生物 |
| ES2731298T3 (es) | 2005-05-27 | 2019-11-14 | Univ North Carolina Chapel Hill | Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas |
| GB0515550D0 (en) | 2005-07-29 | 2005-09-07 | Univ Strathclyde | Inactivation of staphylococcus species |
| WO2007053292A2 (en) * | 2005-10-31 | 2007-05-10 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates |
| JP2009523584A (ja) | 2006-01-24 | 2009-06-25 | ミリメッド・アクティーゼルスカブ | Ph依存性薬物放出を有する医療デバイス |
| US7854923B2 (en) | 2006-04-18 | 2010-12-21 | Endomedix, Inc. | Biopolymer system for tissue sealing |
| CN100441225C (zh) * | 2006-06-29 | 2008-12-10 | 上海交通大学 | 氨基酸改性壳聚糖亲核no供体及其合成方法 |
| GB0707096D0 (en) | 2007-04-12 | 2007-05-23 | Ntnu Technology Transfer As | Method |
| CN101049513B (zh) | 2007-05-13 | 2010-05-19 | 刘万顺 | 水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用 |
| ITMI20071341A1 (it) | 2007-07-05 | 2009-01-06 | Fidia Farmaceutici | Derivati di acido ialuronico contenenti gruppi in grado di rilasciare no |
| EP2209472A1 (en) | 2007-10-12 | 2010-07-28 | The University of North Carolina at Chapel Hill | Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents |
| HUE034051T2 (en) | 2007-11-27 | 2018-01-29 | Algipharma As | Use of alginate-containing oligomers to combat biofilms |
| US20090222088A1 (en) | 2008-02-29 | 2009-09-03 | Medtronic Vascular, Inc. | Secondary Amine Containing Nitric Oxide Releasing Polymer Composition |
| US20090232863A1 (en) | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers |
| EP2260060A4 (en) | 2008-04-01 | 2013-01-16 | Univ Cornell | ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM |
| CN102256989B (zh) | 2008-10-03 | 2016-01-06 | 聚糖生物科学有限责任公司 | 糖基化细菌代谢物的阴离子轭合物 |
| EP2398761A4 (en) | 2009-02-18 | 2015-11-04 | Bezwada Biomedical Llc | CONTROLLED RELEASE OF NITRIC OXIDE AND MEDICINES FROM FUNCTIONALIZED MACROMERS AND OLIGOMERS |
| GB0904941D0 (en) | 2009-03-23 | 2009-05-06 | Ntnu Technology Transfer As | Composition |
| US8709465B2 (en) * | 2009-04-13 | 2014-04-29 | Medtronic Vascular, Inc. | Diazeniumdiolated phosphorylcholine polymers for nitric oxide release |
| US20120107229A1 (en) | 2009-04-15 | 2012-05-03 | Xuefei Huang | Novel nano-probes for molecular imaging and targeted therapy of diseases |
| US9539233B2 (en) | 2009-05-04 | 2017-01-10 | Aridis Pharmaceuticals Inc. | Gallium formulation for the treatment and prevention of infectious diseases |
| GB0909529D0 (en) | 2009-06-03 | 2009-07-15 | Algipharma Ipr As | Alginate oligomers for the inhibition of microbial adherence to surfaces |
| ES2444541T3 (es) | 2009-06-03 | 2014-02-25 | Algipharma As | Oligómeros de alginato para usar para superar la multirresistencia a fármacos en bacterias |
| GB0909557D0 (en) | 2009-06-03 | 2009-07-15 | Algipharma Ipr As | Anti-microbial alginate oligomers |
| US9957341B2 (en) * | 2009-06-09 | 2018-05-01 | William Chambers | Biodegradable absorbent material and method of manufacture |
| CA2671595A1 (en) | 2009-07-09 | 2011-01-09 | Ping I. Lee | Controlled nitric oxide delivery from aqueous s-nitrosothiol conjugated polymers and their complexes |
| US8551456B2 (en) | 2010-03-05 | 2013-10-08 | University Of Dayton | Combination therapy and methods for treating bacterial biofilms |
| EP2547660B1 (en) | 2010-03-19 | 2015-01-07 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Nitroxyl (hno) releasing compounds and uses thereof in treating diseases |
| KR101272351B1 (ko) | 2010-04-23 | 2013-06-07 | 이화여자대학교 산학협력단 | 새로운 카나마이신 화합물, 카나마이신 생산 스트렙토마이세스 속 미생물 및 카나마이신의 생산 방법 |
| KR101255337B1 (ko) | 2010-10-04 | 2013-04-16 | 한국과학기술연구원 | 온도 감응성 합성 고분자를 이용한 일산화질소 전달체 |
| US9034355B2 (en) | 2011-02-24 | 2015-05-19 | Colorado State University Research Foundation | Materials for modulating biological responses and methods of making |
| WO2013029009A1 (en) | 2011-08-24 | 2013-02-28 | Novan, Inc. | Tunable nitric oxide-releasing macromolecules having multiple nitric oxide donor structures |
| GB201116010D0 (en) | 2011-09-15 | 2011-10-26 | Algipharma As | Use of alginate oligomers to enhance the effects of antifungal agents |
| US9017653B2 (en) | 2012-06-14 | 2015-04-28 | The Board Of Regents Of The University Of Texas System | Nitric oxide-releasing compositions and methods |
| CN106986952B (zh) | 2012-08-17 | 2020-03-10 | 北卡罗来纳大学查珀尔希尔分校 | 水溶性的释放一氧化氮的聚葡糖胺和其用途 |
| WO2014138425A1 (en) | 2013-03-08 | 2014-09-12 | Allergan, Inc. | Cyclosporine a-steroid conjugates |
| GB201322777D0 (en) | 2013-12-20 | 2014-02-05 | Algipharma As | Use of alginate oligomers as blood anticoagulants |
| JP2017501221A (ja) | 2013-12-23 | 2017-01-12 | ノルウェージャン ユニバーシティ オブ サイエンス アンド テクノロジー(エヌティーエヌユー) | がん治療におけるオリゴウロン酸塩の使用 |
| RU2016136449A (ru) | 2014-02-28 | 2018-04-02 | АльгиФарма АС | Применение олигометов альгината в лечении муковисцидоза и других состояний, ассоциированных с нарушенной функцией ионных каналов cftr |
| GB201415381D0 (en) | 2014-08-29 | 2014-10-15 | Algipharma As | Inhalable powder formulations of alginate oligomers |
| WO2016073835A1 (en) | 2014-11-06 | 2016-05-12 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods of diazeniumdiolate-based prodrugs for treating cancer |
| GB201504878D0 (en) | 2015-03-23 | 2015-05-06 | Algipharma As | Use of alginate oligomers and CFTR modulators in the treatment of conditions associated with CFTR dysfuntion |
| US11170451B2 (en) | 2015-10-02 | 2021-11-09 | Not So Forgetful, LLC | Apparatus and method for providing gift recommendations and social engagement reminders, storing personal information, and facilitating gift and social engagement recommendations for calendar-based social engagements through an interconnected social network |
| GB201517639D0 (en) | 2015-10-06 | 2015-11-18 | Algipharma As | Use of alginate oligomers to treat or prevent microbial overgrowth in the intestinal tract |
| CN106046382B (zh) | 2016-05-25 | 2018-10-09 | 暨南大学 | 一种装载一氧化氮的阳离子聚合物及其制备方法和应用 |
| WO2018067838A1 (en) | 2016-10-07 | 2018-04-12 | The University Of North Carolina At Chapel Hill | S-nitrosothiol-mediated hyperbranched polyesters |
| WO2018127819A1 (en) | 2017-01-03 | 2018-07-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
| JP7403152B2 (ja) | 2017-03-28 | 2023-12-22 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景 |
| EP3710514B1 (en) | 2017-11-15 | 2023-06-07 | The University of North Carolina at Chapel Hill | Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto |
| CA3091458A1 (en) | 2018-03-06 | 2019-09-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto |
| US11102301B2 (en) | 2018-07-12 | 2021-08-24 | Sap Se | PCA-based scoring of the similarity of damage patterns of operational assets |
| CN113383019B (zh) | 2018-12-28 | 2023-11-17 | 北卡罗来纳大学教堂山分校 | 一氧化氮释放型抗菌聚合物和由其制成的支架和其相关方法 |
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| CA3048785A1 (en) | 2018-07-12 |
| AU2022231716B2 (en) | 2024-05-02 |
| WO2018127819A1 (en) | 2018-07-12 |
| US20210347918A1 (en) | 2021-11-11 |
| CN110198959A (zh) | 2019-09-03 |
| US11697693B2 (en) | 2023-07-11 |
| US20190322770A1 (en) | 2019-10-24 |
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