CN1101804C - Pharmaceutical compound for killing cancer cells and pathogenic bacteria and prepn. method therefor - Google Patents
Pharmaceutical compound for killing cancer cells and pathogenic bacteria and prepn. method therefor Download PDFInfo
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- CN1101804C CN1101804C CN00106238A CN00106238A CN1101804C CN 1101804 C CN1101804 C CN 1101804C CN 00106238 A CN00106238 A CN 00106238A CN 00106238 A CN00106238 A CN 00106238A CN 1101804 C CN1101804 C CN 1101804C
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Abstract
The present invention relates to a medical compound for killing cancer cells and pathogenic bacteria and a preparation method thereof. The medical compound of the present invention has a structural general formula of 2, 6-dimethyl-4-tertiary butyl-nitrobenzene. The preparation method of the present invention has the steps that tertiary butyl alcohol and meta-xylene carry out combination reaction to prepare a tertiary butyl xylene reaction mixture; mixed acid of nitric acid and sulphuric acid is used for proceed nitration reaction; obtained materials react with the tertiary butyl xylene mixture to obtain the compound of the 2, 6-dimethyl-4-tertiary butyl-nitrobenzene of the present invention. The medical compound of the present invention has a medicinal mechanism that heat energy of C element and H element is used for damaging the synthesis of intracellular tumor ribonucleic acid and deoxyribonucleic acid and preventing the cachexia infiltration infection and spreading transition of late tumor virus. The medical compound of the present invention can be used for treating various kinds of internal inflammation and surgical inflammation caused by infection, and has the functions of immune defence realization and immunological surveillance.
Description
The present invention relates to the preparation method of medical compounds and this compound, particularly a kind of medical compounds of killing cancer cells and pathogenic bacterium and preparation method thereof.
At present, both at home and abroad on this chronic disease of treatment malignant tumour, still adopt these old treatment technologies of excision, chemicotherapy and Chinese medicine, though played some mitigations, but the cancer patients is on the one hand when the misery of standing the complication that tumorigenic infection produces torments, bears toxic reaction that radiotherapy, chemotherapy, postoperative metastasis brings again and newly-increased slight illness.A large amount of cancer data of controlling both at home and abroad confirm that also the late tumor cause of death infects and accounts for the first place, and the existing medicine that is used for the treatment of can not solve this medical difficult problem at all.In addition, announce that the people that the whole world is died from approximately because of transmissible disease every year reaches 1,700 ten thousand, this shows that opposing is infected to be still the difficult problem that domestic and international medical skill faces urgent solution according to the World Health Organization.But current medical market both at home and abroad is on the infective inflammation that treatment causes because of all kinds of pathogenic bacterium invasions, and treatment level does not have new breakthrough, though a large amount of microbiotic has been brought into play certain effect, serious its result of treatment of patient is also unsatisfactory for infecting.Invalid as a large amount of ecphyaditis patients because of pharmacological agent, and have to allow the doctor slice off appendix, the patient of countless trouble Digestive tract inflammation diseases does not develop into chronic ulcer because of there being real medicine of curing.Even consider the raising of present resistance, can not illustrate that its drug effect of present medicine is lower.
Purpose of the present invention is exactly in order to overcome above-mentioned weak point of the prior art, to have the cancer controlled, anti-inflammatory, opposing infection and improve compound of immunologic function medicine and preparation method thereof and provide a kind of.
The object of the present invention is achieved like this: its general structure of the compound of this curing cancer drug is: 2, the 6-dimethyl-4-tertiary butyl-oil of mirbane.Its preparation method is: carry out combination reaction with the trimethyl carbinol and m-xylene, aluminum chloride is made catalyzer, make C, H element contact reacts, so that the carbon atom in the above-mentioned reaction, hydrogen atom and Sauerstoffatom enter 2,6 dimethyl of ring structure, 4 tertiary butyls, make tertiary butyl dimethylbenzene reaction mixture.Do into nitroso reaction with nitric acid, sulfuric acid mixing acid, comprising catalyst reaction, form reaction with tertiary butyl xylene mixture, make that C, H, N, O element change into novel substance oil of mirbane, thereby make The compounds of this invention 2, the 6-dimethyl-4-tertiary butyl-oil of mirbane in the molecule of resultant.
Of the present invention have medical compounds 2, a 6-dimethyl-4-tertiary butyl-oil of mirbane of killing cancer cells and pathogenic bacterium function, its medicinal mechanism is: by the thermal energy of C, H element, destroy the synthetic of interior Yeast Nucleic Acid of tumour cell and thymus nucleic acid, stop late tumor virus cachexy to invade moisture feeling and dye, spread transfer, realize " immunosurveillance " from root, and do not damage the human normal cell.
The pharmacological mechanism of medical compounds of the present invention and toxicity test result show that this medicine has all shown certain scientific basis having special curative effect aspect treatment cancer, anti-inflammatory, the opposing infection from pharmacological testing and clinical trial.Do the preliminary identification that ascites carcinoma prolongs life time through Chinese medicine and biological products assay institute tumour expert, Emhorn EAC tumour increase in life span reaches 97.4%, to liver cancer H
22Increase in life span reaches 102.6%.Through the pharmacodynamics primary dcreening operation that industrial hygiene institute of the Ministry of Health carries out mice transplanted tumor, the result shows that The compounds of this invention is to H
22-liver cancer, S-180 sarcoma, ehrlich carcinoma have the effect of killing tumour cell, suppressing tumor proliferative.Go out again through three tentative experiments that do the Room of institute of Materia Medica,Chinese Academy of Medical Sciences pharmacology, The compounds of this invention all has certain antagonistic action to mouse ear inflammation and the rat yeast swollen joint that is caused by Oleum Tiglii, simultaneously passive cutaneous anaphylaxis is also had restraining effect, this index has illustrated that it has antagonism because of immunogen thereby the inflammation that causes.Comprehensive previous experiments proves that The compounds of this invention has the activity of anti inflammatory immunity.About toxicity test, the acute toxicity test of doing through Nat'l Pharmaceutical ﹠ Biological Products Control Institute, its LD
50The credible 17.69-19.7mg/kg that is limited to does not have untoward reaction by actual therapeutic dosage to human body, and toxicity is very little.From chronic toxicity test, that The compounds of this invention does not have is carcinogenic, three intoxicating side effects of mutagenesis, teratogenesis.
Medical compounds of the present invention is compared with existing similar drug, has following advantage and positively effect:
1, dosage is few, cures soon, only kills human cancer cell and pathogenic agent, and injuring normal cell not, does not perform the operation, chemicotherapy not, within effective dose, any untoward reaction do not occur.
2, on the treatment tumour, can kill tumour cell rapidly, suppress tumor cell proliferation, tumour is more and more dwindled, and it is painful to remove play fast, increases patient's appetite, refreshes.The 1cm-2cm tumour of early discovery is expected to cure.
3, on the various Medicine and Surgery inflammation that treatment causes because of infection, pathogenic bacterium can be disposablely killed in oral administration and external application.Treatment trauma infection contamination, skin infection after scald, skin ulcer, carbuncle poison are disliked the sore curative ratio and are reached 100%.This medicine can be single oral, soup can be directly used in focus again, such application method and effect be other medicines can not than.
4, at immunology, this medicine not only has powerful killing power to pathogenic agent and at the toxic product that human body produces, and can also in human body, really give play to immunologic function, promptly effectively stop the invasion of causal organism, suppress the breeding of causal organism, kill the pathogenic agent of invasion, remove the toxic action of its generation, realize the function of immune defense, immunosurveillance.
For further specifying the result of treatment of medical compounds of the present invention, provide following case below:
Case 1: Tian Ruihe, man, peasant, chest grew three lumps in 85 years, patient age was 68 years old at that time, and plump county people's hospital is diagnosed as pleura skin cancer through Hebei province, is in a bad way, pain unbearably, the diet difficulty is taken pharmacological agent of the present invention 75 days upon somebody's introduction, and three tumours all disappear, physical recovery health, the not recurrence in 11 years of surviving.
Case 2: the red tongued bell that shakes, the man, the peasant suffered from laryngocarcinoma in 84 years, patient age was 55 years old at that time, earlier after Tangshan City Worker's Hospital, the treatment of Tianjin tumour hospital, radiotherapy after 36 days doctor's decision go home to have a rest and do resection operation again after three weeks.Patient's symptom was mute at that time, and the diet difficulty is in a bad way.After use medicine of the present invention upon somebody's introduction, after the medication in several days, the state of an illness take a favorable turn, and sick painful the disappearance also can go out sound in a minute, continuous use is after one month again, patient recovers normally substantially, and meal is eaten more and morely, and mental attitude and ordinary person are as good as, the patient can go to market by bike and sell dish after 1 year, so far for 11 years.
Case 3: Tian Zhong, the man, 81 years old, in August, 98, misnicturition just can not arranged urine and pain unbearably afterwards, was prostate cancer through Huabei Coal Medical Sciences College, PLA's the 255th hospital diagnosis, need perform an operation, but the old man adheres to not doing and requires to go home and waits for death, and the state of an illness is more serious afterwards, and two sons have prepared funeral affairs.Hear that medicine of the present invention may be effective this moment, have the idea of trying in arms and bought nine capsule preparations of making by The compounds of this invention, take and promptly saw special effect in one day, it is no longer difficult to urinate, and sb.'s illness took a favorable turn two days later, and stool and urine is normal, take 60 again continuously and just fully recovered, until now not repeatedly.
Case 4: Yu Yanchun, the man, 70 years old, suffered from prostate cancer at tumour hospital of Beijing medical courses in general institute excision in 96 years, after due to illness feelings shift to infect and increase the weight of, done second operation again, but the postoperative time is not long, it is still more and more difficult to urinate, the state of an illness increases the weight of.Listen the people to introduce in April, 94 and begin to use pharmacological agent of the present invention, take 27 capsule preparations of the present invention continuously, urine has just been arranged, and takes 130 more continuously afterwards, and basic the recovery normally paid a return visit in 99 years, and the patient can do farm work.
Case 5: Zhang Xiujuan, the woman, 49 years old, suffered from stomach ulcer 26 years, twice operation of being in hospital, but the state of an illness is really more and more heavier, and in poor health, can not work for a long time.Introduce through the doctor and take capsule preparations of the present invention 97 year winter, takes 20 and just take effect greatly, takes 50 again continuously, and stomach ulcer is thoroughly cured, so far not recurrence.
Case 6: Wang Huizhong, the man, 55 years old, draw the concurrent osteomyelitis of fracture, successively operated on 10 times in Tangshan Orthopaedics Hospital in 96～98 years because of suppuration, use multiple antibiotic therapy, can not cure because of infecting seriously.Introduce through the doctor in September, 98, and with medicine external curing of the present invention, a drug is promptly thoroughly cured.
Case 7: 36 acute or chronic appendicitis patients such as Li Xingzhong, Du Yanling, oral capsule preparations a drug of the present invention is just thoroughly cured, and none recurrence is wherein most previous invalid with various antibiotic therapies.
Purpose of the present invention can realize by following embodiment:
One, the composition of material medicine and source: nitric acid, sulfuric acid, m-xylene, propyl carbinol, the trimethyl carbinol, aluminum chloride, calcium chloride, hexanol, domestic Beijing, Shanghai chemical reagent factory can provide, but also import.
Two, synthesis step and condition:
1, carries out combination reaction with the trimethyl carbinol and m-xylene, aluminum chloride is made catalyzer, make C, H element contact reacts,, make tertiary butyl dimethylbenzene reaction mixture so that the carbon atom in the above-mentioned reaction, hydrogen atom and Sauerstoffatom enter 2,6 dimethyl of ring structure, 4 tertiary butyls.
2, do into nitroso reaction with nitric acid, sulfuric acid mixing acid, comprising catalyst reaction, form reaction with tertiary butyl xylene mixture, make that C, H, N, O element change into novel substance oil of mirbane, thereby make The compounds of this invention 2, the 6-dimethyl-4-tertiary butyl-oil of mirbane in the molecule of resultant.
3, quicken chemical reaction rate with the variation of control reaction temperature in the above-mentioned reaction process, make reaction mixture and resultant reach chemical equilibrium gradually, temperature of reaction is divided three sections controls, and its span of control is: 20-30 ℃, 40-70 ℃, 70-100 ℃.
Claims (1)
1, a kind of preparation method who kills the medical compounds of cancer cells and pathogenic bacterium, the general structure of this medical compounds is: 2, the 6-dimethyl-4-tertiary butyl-oil of mirbane is characterized in that the preparation method of this medical compounds is:
A, carry out combination reaction with the trimethyl carbinol and m-xylene, aluminum chloride is made catalyzer, make C, H element contact reacts,, make tertiary butyl dimethylbenzene reaction mixture so that the carbon atom in the above-mentioned reaction, hydrogen atom and Sauerstoffatom enter 2,6 dimethyl of ring structure, 4 tertiary butyls;
B, do into nitroso reaction,, form reaction, make C, H, N, O element in the molecule of resultant change into novel substance: oil of mirbane with tertiary butyl xylene mixture comprising catalyst reaction with nitric acid, sulfuric acid mixing acid;
C, above-mentionedly advance in the nitroso reaction process, take asymptoticly to heat catalysis and quicken chemical reaction rate with the variation of control reaction temperature, make reaction mixture and resultant reach chemical equilibrium gradually, temperature of reaction is divided three sections controls, and its span of control is: low-temperature zone 20-30 ℃, middle-temperature section 40-70 ℃, high temperature section 70-100 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00106238A CN1101804C (en) | 2000-04-29 | 2000-04-29 | Pharmaceutical compound for killing cancer cells and pathogenic bacteria and prepn. method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00106238A CN1101804C (en) | 2000-04-29 | 2000-04-29 | Pharmaceutical compound for killing cancer cells and pathogenic bacteria and prepn. method therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1277956A CN1277956A (en) | 2000-12-27 |
| CN1101804C true CN1101804C (en) | 2003-02-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00106238A Expired - Fee Related CN1101804C (en) | 2000-04-29 | 2000-04-29 | Pharmaceutical compound for killing cancer cells and pathogenic bacteria and prepn. method therefor |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103254085B (en) * | 2013-01-21 | 2014-10-29 | 齐金 | Musk 207 synthesis method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121832A (en) * | 1994-04-08 | 1996-05-08 | 北京市兴大科学系统公司 | Anticancer drug |
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2000
- 2000-04-29 CN CN00106238A patent/CN1101804C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121832A (en) * | 1994-04-08 | 1996-05-08 | 北京市兴大科学系统公司 | Anticancer drug |
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| CN1277956A (en) | 2000-12-27 |
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Granted publication date: 20030219 Termination date: 20160429 |