CN110179954A - A kind of traditional Chinese medicine oral liquid antiviral for livestock and poultry and preparation method thereof - Google Patents
A kind of traditional Chinese medicine oral liquid antiviral for livestock and poultry and preparation method thereof Download PDFInfo
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Abstract
A kind of traditional Chinese medicine oral liquid antiviral for livestock and poultry, it is characterised in that, the principal component of the traditional Chinese medicine oral liquid is made of Radix Isatidis, reed root, glutinous rehmannia, gypsum, Pogostemon cablin, Radix Curcumae, rhizoma anemarrhenae, rhizoma acori graminei, Fructus Forsythiae.The present invention provides a kind of traditional Chinese medicine oral liquids antiviral for livestock and poultry, substitute antiviral and part antibiotic chemicals, reduce antiviral and chemistry of antibiotics drug and abuse, misuse and high dose use in the domestic market；It is the invention preparation method and simple process, easy, avoid cumbersome middle chemicals contamination and contamination of products.In addition, Chinese medicine dreg can be used as, collected manure is supported agriculture and Chinese medicine product beneficial flora is further cultured for.
Description
Technical field
The present invention relates to livestock and poultry traditional Chinese medicine oral liquid fields, and in particular to a kind of traditional Chinese medicine oral liquid antiviral for livestock and poultry and
Preparation method.
Background technique
Two season of winter in spring is that domestic animals and birds catch a cold high-incidence season, and two season of winter in spring is dry, and temperature is sometimes hot and sometimes cold, warm round the clock
Poor big, various stress factors increase, it is easy to and the integrality for destroying upper respiratory tract mucous membrane is allowed to the ability decline that rejects, furthermore by
In the infection of virus and into livestock and poultry respiratory system, causes various pathogen to be taken advantage of a weak point and cause to fall ill, cause Abwehrkraft des Koepers
Decline, when having cold stress, cold airflow stimulates respiratory mucosa, and at this time mucous membrane is easy to happen the inflammation such as oedema, hyperemia, causes to raise
Mucus is had inside class and birds tracheae, has noise in breathing, causes viral respiratory disease, so as to cause viral sexy
It emits.
Vehicles Collected from Market treats the Chinese medicine of fowl poultry kind flu, and anemofrigid cold is Antiphlogistic Powder of Schizonepetae and Ledebouriellae；Anemopyretic cold is swap buffers system
Agent.It is opened currently without the traditional Chinese medicine oral liquid prescription antiviral for livestock and poultry is badly in need of one is two kinds of tcm products being suitable for of catching a cold
Hair.
Summary of the invention
In view of the above-mentioned problems, the purpose of the present invention is to provide a kind of traditional Chinese medicine oral liquid antiviral for livestock and poultry, it is special
Sign is that the principal component of the traditional Chinese medicine oral liquid is by Radix Isatidis, reed root, glutinous rehmannia, gypsum, Pogostemon cablin, Radix Curcumae, rhizoma anemarrhenae, stone Chang
Pu, Fructus Forsythiae composition.
Further, traditional Chinese medicine oral liquid is made of the Chinese medicine of following parts by weight: 25-30 parts of Radix Isatidis, reed root 6-12
Part, 6-10 parts of glutinous rehmannia, 5-10 parts of gypsum, 5-10 parts of Pogostemon cablin, 4-9 parts of Radix Curcumae, 4-9 parts of rhizoma anemarrhenae, 4-9 parts of rhizoma acori graminei, Fructus Forsythiae
0.8-2 parts.
Further, further include two or more in following auxiliary material: 3-5 parts of Tween 80,1-3 parts of benzyl alcohol, ethyl alcohol
4-8 parts, 0.2-1 parts of ethylparaben.
It further, further include 2-5 parts of sucrose or 2-4 parts of honey.
Further, the traditional Chinese medicine oral liquid is made of the Chinese medicine of following parts by weight: 30 parts of Radix Isatidis, reed root 12
Part, 9 parts of glutinous rehmannia, 10 parts of gypsum, 9 parts of Pogostemon cablin, 6 parts of Radix Curcumae, 6 parts of rhizoma anemarrhenae, 6 parts of rhizoma acori graminei, 1.8 parts of Fructus Forsythiae.
A kind of preparation method of the traditional Chinese medicine oral liquid antiviral for livestock and poultry, it is characterised in that include the following steps:
S1: 0.5-1.5 times of amount of gypsum is purified water retting 2 hours, is boiled 3-5 hours, supernatant is collected；
S2: measuring brand-new with 4-8 times in proportion for Chinese medicine principal component and purify water retting 4 hours, extraction 2 times, and 1 hour every time,
Combined extract adds supernatant obtained in S1 step wherein, and after three layers of filtered through gauze, being concentrated into relative density is
1.25-1.55；
S3: ethylparaben is added in 95% ethyl alcohol, stirring is to being completely dissolved；
S4: solution obtained in S3 is added in solution made from step S2, is proportionally added into auxiliary material, stirring is lower while adding
Enter purified water to being completely dissolved and be uniformly mixed；
S5: in the solution made from step S4 plus purified water is to full dose, and the lower decoloration of 0.1% needle-use activated carbon stirring is added
20-30 minutes, coarse filtration took off charcoal；
S6: sampling, after the inspection of semifinished product is qualified, cross 0.8um water system miillpore filter refined filtration to clarity it is qualified after packing plus
Lid, labeling, packaging are 100ml per bottled amount to get antiviral oral liquor.
The present invention has the advantages that
1, the present invention provides a kind of traditional Chinese medicine oral liquids antiviral for livestock and poultry, substitute antiviral and part antibiotic
Chemicals reduce antiviral and chemistry of antibiotics drug abuse；Preparation method and technology is simple, easy, avoids in cumbersome
Chemicals contamination and contamination of products.In addition, Chinese medicine dreg can be used as, collected manure is supported agriculture and Chinese medicine product beneficial flora is further cultured for.
2, traditional Chinese medicine oral liquid provided by the invention has effects that clearing heat and expelling damp, removing pattogenic heat from the blood and toxic material from the body, is used for the various flu of livestock and poultry
Caused fever and respiratory tract infection, the treatment of the diseases of viral infection such as influenza infection, application method is simple, mouthfeel
It is good, increase animal and takes orally compliance.
Specific embodiment
The present invention provides a kind of traditional Chinese medicine oral liquids antiviral for livestock and poultry, it is characterised in that, the traditional Chinese medicine oral liquid
Principal component be made of Radix Isatidis, reed root, glutinous rehmannia, gypsum, Pogostemon cablin, Radix Curcumae, rhizoma anemarrhenae, rhizoma acori graminei, Fructus Forsythiae.
Radix Isatidis, cold in nature, bitter, return heart, stomach meridian have the effect of clearing heat and detoxicating, cool blood relieving sore-throat.When being usually used in warm epidemic disease
Poison, pharyngalgia of generating heat, febrile virulent maculae, mumps, scarlet fever, major part pestilence, erysipelas, carbuncle swells.
Reed root, it is cold in nature, it is sweet in flavor, attach to the lung and stomach meridians, have clearing heat-fire, promote the production of body fluid to quench thirst, relieving restlessness, preventing or arresting vomiting, diuresis the effect of,
For pyreticosis and polydipsia, cough with lung heat, lung carbuncle pyemesis, gastropyretic vomiting, puckery pain of heat gonorrhea.
Glutinous rehmannia, cold in nature, sweet in flavor, bitter, return heart, liver and kidney channel have the effect of clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, join the army for heat
Blood, febrile virulent maculae, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue are spitted blood, bleeding from five sense organs or subcutaneous tissue, abscess of throat, Heat Diabetes.
Gypsum, it is property Great Cold, sweet in flavor, pungent, it attaches to the lung and stomach meridians, there is the effect of clearing heat-fire, relieving restlessness quench the thirst, be used for outer sensible heat
Disease, cough with lung heat, stomach fire Kang Sheng, headache, is had a toothache at hyperpyrexia polydipsia.Main component is calcium sulphate dihydrate.
The effect of Pogostemon cablin, slightly warm in nature, acrid flavour, returns spleen, stomach, lung channel have and eliminate dampness with aromatics and middle preventing or arresting vomiting, deliver relieving summer-heat.
For turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, summer-heat and damp exterior syndrome, damp-warm syndrome from the beginning of, burnout of generating heat is uncomfortable in chest not relax, and cold-dampness closes heat, and abdominal pain is vomited and diarrhoea,
Nasosinusitis headache.
Radix Curcumae, cold in nature, acrid flavour, hardship return liver, the heart, lung channel, have promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, clear away heart-fire cool blood, and cholagogue moves back
The effect of yellow, is used for pricking pain in the chest, chest impediment and cardialgia, pyreticosis coma, blood-head, jaundice and reddish urine.
Rhizoma anemarrhenae, cold in nature, sweet in flavor, bitter, return lung, stomach, kidney channel have clearing heat-fire, nourishing Yin and moistening dryness.It is high for fever caused by exogenous pathogenic factors
Hot polydipsia, lung heat is dry thirsty, Heat Diabetes, dry constipation of intestines.Main component is mangiferin, rhizoma anemarrhenae saponin BII.
Rhizoma acori graminei, warm-natured, acrid flavour, hardship, return heart, stomach meridian have slit phlegm of having one's ideas straightened out, inducing resuscitation intelligence development, and dampness elimination appetizing is used for coma
Epilepsy, tinnitus, gastral cavity ruffian is not hungry.
Fructus Forsythiae, cold nature, bitter, return lung, the heart, small intestinl channel have the effect of clearing heat and detoxicating, dispersing swelling and dissipating binds, dispelling wind and heat from the body,
For ulcer, scrofula, acute mastitis, erysipelas, warm, hyperpyrexia polydipsia, coma macular eruption, the symptoms such as puckery pain of heat gonorrhea.Main component is Fructus Forsythiae
Glycosides, forsythiaside A.
Embodiment one:
The principal component of traditional Chinese medicine oral liquid are as follows: Radix Isatidis 300g, reed root 120g, glutinous rehmannia 80g, gypsum 80g, Pogostemon cablin 68g are strongly fragrant
Golden 60g, rhizoma anemarrhenae 60g, rhizoma acori graminei 60g, Fructus Forsythiae 12g.Auxiliary material includes: Tween 80 30ml, benzyl alcohol 10ml, 95% ethyl alcohol 40ml,
Ethylparaben 2g, sucrose 20g.
Manufacture craft are as follows:
S1: 1 times of amount of gypsum is purified water retting 2 hours, is boiled 5 hours, supernatant is collected；
S2: Chinese medicine principal component is purified water retting 4 hours with 6 times of amount brand-news in proportion, is extracted 2 times, 1 hour every time, is closed
And extracting solution, supernatant obtained in S1 step is added wherein, after three layers of filtered through gauze, being concentrated into relative density is
1.41；
S3: ethylparaben is added in 95% ethyl alcohol, stirring is to being completely dissolved；
S4: solution obtained in S3 is added in solution made from step S2, auxiliary material Tween 80, benzyl alcohol are proportionally added into
And sucrose, stirring is lower while purified water is added to being completely dissolved and be uniformly mixed；
S5: in the solution made from step S4 plus purified water is to full dose, and the lower decoloration 25 of 0.1% needle-use activated carbon stirring is added
Minute, coarse filtration takes off charcoal；
S6: sampling, after the inspection of semifinished product is qualified, cross 0.8um water system miillpore filter refined filtration to clarity it is qualified after packing plus
Lid, labeling, packaging are 100ml per bottled amount to get antiviral oral liquor.
Embodiment two:
The principal component of traditional Chinese medicine oral liquid are as follows: Radix Isatidis 290g, reed root 120g, glutinous rehmannia 90g, gypsum 100g, Pogostemon cablin 80g,
Radix Curcumae 75g, rhizoma anemarrhenae 70g, rhizoma acori graminei 70g, Fructus Forsythiae 20g.Auxiliary material includes: Tween 80 35ml, benzyl alcohol 10ml, 95% ethyl alcohol
50ml, ethylparaben 2g, sucrose 25g.
Manufacture craft are as follows:
S1: 0.8 times of amount of gypsum is purified water retting 2 hours, is boiled 4 hours, supernatant is collected；
S2: measuring brand-new with 4-8 times in proportion for Chinese medicine principal component and purify water retting 4 hours, extraction 2 times, and 1 hour every time,
Combined extract adds supernatant obtained in S1 step wherein, and after three layers of filtered through gauze, being concentrated into relative density is
1.39；
S3: ethylparaben is added in 95% ethyl alcohol, stirring is to being completely dissolved；
S4: solution obtained in S3 is added in solution made from step S2, auxiliary material Tween 80, benzyl alcohol are proportionally added into
And sucrose, stirring is lower while purified water is added to being completely dissolved and be uniformly mixed；
S5: in the solution made from step S4 plus purified water is to full dose, and the lower decoloration 20 of 0.1% needle-use activated carbon stirring is added
Minute, coarse filtration takes off charcoal；
S6: sampling, after the inspection of semifinished product is qualified, cross 0.8um water system miillpore filter refined filtration to clarity it is qualified after packing plus
Lid, labeling, packaging are 100ml per bottled amount to get antiviral oral liquor.
Embodiment three:
The principal component of traditional Chinese medicine oral liquid are as follows: Radix Isatidis 300g, reed root 110g, glutinous rehmannia 85g, gypsum 90g, Pogostemon cablin 70g are strongly fragrant
Golden 70g, rhizoma anemarrhenae 60g, rhizoma acori graminei 60g, Fructus Forsythiae 20g.Auxiliary material includes: Tween 80 30ml, benzyl alcohol 10ml, 95% ethyl alcohol 45ml,
Ethylparaben 2g, sucrose 25g.
Manufacture craft are as follows:
S1: 1.2 times of amounts of gypsum are purified water retting 2 hours, are boiled 5 hours, supernatant is collected；
S2: Chinese medicine principal component is purified water retting 4 hours with 7 times of amount brand-news in proportion, is extracted 2 times, 1 hour every time, is closed
And extracting solution, supernatant obtained in S1 step is added wherein, after three layers of filtered through gauze, being concentrated into relative density is
1.33；
S3: ethylparaben is added in 95% ethyl alcohol, stirring is to being completely dissolved；
S4: solution obtained in S3 is added in solution made from step S2, auxiliary material Tween 80, benzyl alcohol are proportionally added into
And sucrose, stirring is lower while purified water is added to being completely dissolved and be uniformly mixed；
S5: in the solution made from step S4 plus purified water is to full dose, and the lower decoloration 30 of 0.1% needle-use activated carbon stirring is added
Minute, coarse filtration takes off charcoal；
S6: sampling, after the inspection of semifinished product is qualified, cross 0.8um water system miillpore filter refined filtration to clarity it is qualified after packing plus
Lid, labeling, packaging are 100ml per bottled amount to get antiviral oral liquor.
Experimental program:
The application of oral solution sample clinically through the invention determines that oral solution of the present invention is cold to two monsoon of winter in poultry spring
Flu prevents, treats effect, as bird performance haves a low fever, cold hair is inverse vertical.Amount of drinking water decline, the feed intake decline of birds
Deng.
Test selection age in days is close, and the group of chicken similar in above-mentioned morbidity sign is tested.Using oral solution group of the present invention, double
Coptis oral solution group.It routinely requires to carry out feeding management and be immunized.
The comparative experiments product of this test of test material are provided by research and development centre, Tianjin Ringpu Bio-technology Co., Ltd.,
250ml/ bottles of Shuanghuanglian oral liquid, lot number: 20181001.Test specimen: antiviral oral liquor of the embodiment of the present invention, 100ml/
Bottle, lot number: 20190101.
Test method control group and test group are all made of the consistent feeding standard of test chicken factory and daily ration.Test group is to prescription
Method: the usage and dosage of drinking water administration is: oral solution of the embodiment of the present invention, is watered 150 jin by every bottle, concentrates drinking-water, once a day,
It is used in conjunction 5 days.Shuanghuanglian oral liquid group is watered 150 jin by every bottle, concentrates drinking-water, once a day, is used in conjunction 5 days.Compare chicken within medication 5 days
Group's effective percentage, cure rate, the death rate, respiratory disease control and recovery situation and the state of mind etc..
Experimental result is detailed in following table:
| Group | Chicken quantity (only) | Disease incidence | It is efficient | Cure rate | The death rate |
| Healthy control group | 200 | 0 | - | - | - |
| Clear water control group | 200 | 85% | - | - | - |
| One group of embodiment | 200 | 84% | 98.81% | 95.24% | 0.60% |
| Two groups of embodiment | 200 | 86% | 98.26% | 96.51% | 1.16% |
| Three groups of embodiment | 200 | 85% | 98.82% | 97.06% | 0% |
| Swap buffers group | 200 | 85% | 71.18% | 58.82% | 10% |
As can be seen from the above results, according to clinical verification, antiviral oral liquor group of the present invention is caused by virus to birds
Malaise symptoms treatment condition is substantially better than Shuanghuanglian oral liquid group, and the death rate significantly reduces.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (6)
1. a kind of traditional Chinese medicine oral liquid antiviral for livestock and poultry, it is characterised in that, the principal component of the traditional Chinese medicine oral liquid is by plate
Lan Gen, reed root, glutinous rehmannia, gypsum, Pogostemon cablin, Radix Curcumae, rhizoma anemarrhenae, rhizoma acori graminei, Fructus Forsythiae composition.
2. a kind of traditional Chinese medicine oral liquid antiviral for livestock and poultry as described in claim 1, it is characterised in that, the extract oral
Liquid is made of the Chinese medicine of following parts by weight: 25-30 parts of Radix Isatidis, 6-12 parts of reed root, and 6-10 parts of glutinous rehmannia, gypsum 5-10
Part, 5-10 parts of Pogostemon cablin, 4-9 parts of Radix Curcumae, 4-9 parts of rhizoma anemarrhenae, 4-9 parts of rhizoma acori graminei, 0.8-2 parts of Fructus Forsythiae.
3. a kind of traditional Chinese medicine oral liquid antiviral for livestock and poultry as described in claim 1, it is characterised in that further include following auxiliary
Two or more in material: 3-5 parts of Tween 80,1-3 parts of benzyl alcohol, 4-8 parts of ethyl alcohol, 0.2-1 parts of ethylparaben.
4. a kind of traditional Chinese medicine oral liquid antiviral for livestock and poultry as described in claim 1, which is characterized in that further include sucrose 2-
5 parts or 2-4 parts of honey.
5. a kind of traditional Chinese medicine oral liquid antiviral for livestock and poultry as described in claim 1, it is characterised in that the extract oral
Liquid is made of the Chinese medicine of following parts by weight: 30 parts of Radix Isatidis, 12 parts of reed root, and 9 parts of glutinous rehmannia, 10 parts of gypsum, Pogostemon cablin 9
Part, 6 parts of Radix Curcumae, 6 parts of rhizoma anemarrhenae, 6 parts of rhizoma acori graminei, 1.8 parts of Fructus Forsythiae.
6. a kind of preparation method of the traditional Chinese medicine oral liquid antiviral for livestock and poultry as described in claim 1, it is characterised in that packet
Include following steps:
S1: 0.5-1.5 times of amount of gypsum is purified water retting 2 hours, is boiled 3-5 hours, supernatant is collected；
S2: measuring brand-new with 4-8 times in proportion for Chinese medicine principal component and purify water retting 4 hours, extracts 2 times, 1 hour every time, merges
Extracting solution adds supernatant obtained in S1 step wherein, and after three layers of filtered through gauze, being concentrated into relative density is 1.25-
1.55；
S3: ethylparaben is added in 95% ethyl alcohol, stirring is to being completely dissolved；
S4: solution obtained in S3 is added in solution made from step S2, is proportionally added into auxiliary material, stirring is lower while being added pure
Change water to being completely dissolved and be uniformly mixed；
S5: in the solution made from step S4 plus purified water is to full dose, and the lower 20-30 that decolourizes of 0.1% needle-use activated carbon stirring is added
Minute, coarse filtration takes off charcoal；
S6: sampling, after the inspection of semifinished product is qualified, cross 0.8um water system miillpore filter refined filtration to clarity it is qualified after packing, cover,
Labeling, packaging are 100ml per bottled amount to get antiviral oral liquor.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1824269A (en) * | 2005-12-28 | 2006-08-30 | 程雪翔 | Xinshenghua oral liquid and its preparation method |
| CN1840064A (en) * | 2006-01-20 | 2006-10-04 | 丽珠医药集团股份有限公司 | Medicine composition for treating bird flu, its preparation method and use |
| CN101919959A (en) * | 2009-06-16 | 2010-12-22 | 丽珠医药集团股份有限公司 | Drug composition for preventing and treating swine influenza and preparation method and application thereof |
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2019
- 2019-07-11 CN CN201910624611.6A patent/CN110179954A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1824269A (en) * | 2005-12-28 | 2006-08-30 | 程雪翔 | Xinshenghua oral liquid and its preparation method |
| CN1840064A (en) * | 2006-01-20 | 2006-10-04 | 丽珠医药集团股份有限公司 | Medicine composition for treating bird flu, its preparation method and use |
| CN101919959A (en) * | 2009-06-16 | 2010-12-22 | 丽珠医药集团股份有限公司 | Drug composition for preventing and treating swine influenza and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
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| 刘小艳: "防腐剂在中兽药口服液中的应用", 《中国兽药杂志》 * |
| 康志英等: "抗病毒口服液中广藿香含量测定方法研究", 《中国医药导报》 * |
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