CN110179888A - A kind of arcotic oral solution and preparation method thereof for gastric operation - Google Patents
A kind of arcotic oral solution and preparation method thereof for gastric operation Download PDFInfo
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- CN110179888A CN110179888A CN201910531541.XA CN201910531541A CN110179888A CN 110179888 A CN110179888 A CN 110179888A CN 201910531541 A CN201910531541 A CN 201910531541A CN 110179888 A CN110179888 A CN 110179888A
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
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- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61P23/02—Local anaesthetics
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The arcotic oral solution and preparation method thereof that the invention discloses a kind of for gastric operation, its raw material includes: 0.5 part -1 part of cannabidiol, 0.6 part -0.8 part of Propofol, 3 parts -4 parts of Chinese medical extract, 0.2 part -0.4 part of procaine hydrochloride, 2 parts -3 parts of vitamin E, 4 parts -6 parts of ascorbic acid, 0.5 part -1 part of sodium bicarbonate, 0.5 part -1 part of Lactis Anhydrous, -8 parts of phosphatidase 5 part, 1 part -3 parts of cosolvent and 66 parts -75 parts of purified water by weight, and the present invention relates to gastric operation technical fields.This is used for the arcotic oral solution and preparation method thereof of gastric operation, with to stomach have good local anaesthetic effect, and side effect is very small, reduce narcotics injury caused by patient, insecurity when patient uses is reduced, improves the therapeutic effect of patient to a certain extent, it is practical, and dissolution of raw material degree is high in the preparation, the holding time is long.
Description
Technical field
The present invention relates to gastric operation technical field, specially a kind of arcotic oral solution and its system for gastric operation
Preparation Method.
Background technique
In existing gastric operation therapeutic process, needs according to circumstances to carry out stomach and cut progress local treatment, stomach hand
Art compares pain, so needing to be anaesthetized in the preoperative, and patient's pain after oral anesthesia is substantially reduced, general step
It is divided into anesthesia, incision, cleaning, drainage etc., the arcotic oral solution of existing gastric operation is very widely used, but also deposits
In following problems.
1. the arcotic oral solution of existing gastric operation, the effect of general local anaesthesia is not fine, and side effect is very
Greatly, the injury caused by patient is bigger, increases insecurity when patient uses.
2. the arcotic oral solution of existing gastric operation, dissolution of raw material degree is not high in the preparation, and the holding time is not
It is very long.
Therefore it is badly in need of solving the problems, such as that the arcotic oral solution side effect of gastric operation is big and solute effect is bad.
Summary of the invention
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides a kind of for the arcotic oral solution of gastric operation and its preparation
Method solves the problems, such as that the arcotic oral solution side effect of gastric operation is big and solute effect is bad.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs: a kind of anesthesia for gastric operation
Medicine oral solution, raw material include: 0.5 part -1 part of cannabidiol, 0.6 part -0.8 part of Propofol, Chinese medical extract by weight
3 parts -4 parts, 0.2 part -0.4 part of procaine hydrochloride, 2 parts -3 parts of vitamin E, 4 parts -6 parts of ascorbic acid, sodium bicarbonate 0.5
- 1 part of part, 0.5 part -1 part of Lactis Anhydrous, -8 parts of phosphatidase 5 part, 1 part -3 parts of cosolvent and 66 parts -75 parts of purified water.
Preferably, the Chinese medical extract is by Celastrus orbiculatus Thunb. Extract, Benzoinum extract, Huashan conopsea extraction and old crane
Careless extract composition, and weight part ratio are as follows: 30 parts -35 parts of Celastrus orbiculatus Thunb. Extract, 35 parts -40 parts of Benzoinum extract, Physochlaina macrophylla
10 parts -12 parts and 14 parts -20 parts of heroubill extract of extract, the fruit of celastrus orbiculatus has the effect of calmness of calming the nerves, for nerve
Weak, palpitaition, insomnia and amnesia, styrax and Moschus, storax have effect of having one's ideas straightened out, can treat and suddenly faint, mandibular joint is tight
It closes etc. and to close de- card, but the power of its resuscitation with aromatics has strong, weak difference, Moschus acts on most strong, the function that styrax, storax are had one's ideas straightened out
It is similar, and Moschus has promoting qi circulation and removing obstruction in the collateral concurrently, the function of swelling and pain relieving, styrax and can the promoting flow of qi and blood circulation, and can be used for trusted subordinate's pain, postpartum
The disease of bruise.
Preferably, the cosolvent is made of ethyl alcohol.
Preferably, the antioxidant is made of riboflavin.
The invention also discloses a kind of preparation methods of arcotic oral solution for gastric operation, specifically include following step
It is rapid:
S1, it puts into pulverizer and carries out after celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill raw material are respectively washed removal of impurities
It crushes, then smashed raw material is respectively charged into digester, 80% concentration ethanol solution is added and is extracted, heats back
Stream 0.5-1.5 hours, temperature recycling design between 45-55 DEG C obtains celastrus orbiculatus, styrax, the Huashan after 0.5-1.5 hours
The extract liquor of ginseng and heroubill, is added active carbon in extraction solution, filters after stirring half an hour decoloration immediately, removes active carbon
And pigment, it obtains after filtered celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill extract liquor are mixed by blender
Medicament extract；
S2, purified water is added in stirring container, then by vitamin E, ascorbic acid, phosphatide, glyceride and anhydrous
Lactose is dissolved in purified water, stirs to after being completely dissolved, and cannabidiol, Propofol, procaine hydrochloride, cosolvent is added and resists
Oxidant is again stirring for being completely dissolved；
S3, the solution that completion is dissolved into S2 pour into mixing arrangement, and Chinese medical extract is then added to mixing arrangement
Interior by being stirred in stirring rod, manganese hydrogen sodium regulating solution pH is added in stirring after twenty minutes, and active carbon room temperature is then added
35min is adsorbed, carbon removal is filtered, it is spare with being placed after 0.22 μm of sterile filtering with microporous membrane degerming；
S4, it will be placed in S3 and carried out by bottle placer after spare solution sterilization filling, then sealing obtains after being packaged
Oral liquid medicine.
Preferably, the temperature of thermal reflow controls between 50-60 DEG C in the S1.
Preferably, the form of procaine hydrochloride is powdery in the S2.
(3) beneficial effect
The arcotic oral solution and preparation method thereof that the present invention provides a kind of for gastric operation.Compared with prior art
Have following the utility model has the advantages that this is used for arcotic oral solution of gastric operation and preparation method thereof, raw material wraps by weight
It includes: 0.5 part -1 part of cannabidiol, 0.6 part -0.8 part of Propofol, 3 parts -4 parts of Chinese medical extract, 0.2 part of procaine hydrochloride -
0.4 part, 2 parts -3 parts of vitamin E, 4 parts -6 parts of ascorbic acid, 0.5 part -1 part of sodium bicarbonate, 0.5 part -1 part of Lactis Anhydrous, phosphorus
5 parts -8 parts of rouge, 1 part -3 parts of cosolvent and 66 parts -75 parts of purified water have to the good local anaesthetic effect of stomach, and secondary work
With very small, reduce narcotics injury caused by patient, reduces insecurity when patient uses, to a certain extent
The therapeutic effect of patient is improved, it is practical, and dissolution of raw material degree is high in the preparation, the holding time is long, has very to stomach
Good local anaesthetic effect.
Detailed description of the invention
Fig. 1 is experimental data statistical form figure of the present invention.
Specific embodiment
It is clearly and completely described below in conjunction with the technical solution in the embodiment of the present invention, it is clear that described reality
Applying example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is general
Logical technical staff every other embodiment obtained without making creative work belongs to what the present invention protected
Range.
Referring to Fig. 1, the embodiment of the present invention provides a kind of three kinds of technical solutions: arcotic oral solution for gastric operation
Preparation method, specifically include following embodiment:
Embodiment 1
S1, it puts into pulverizer and carries out after celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill raw material are respectively washed removal of impurities
It crushes, then smashed raw material is respectively charged into digester, 80% concentration ethanol solution is added and is extracted, heats back
Stream 0.5 hour, temperature recycling design between 45 DEG C obtains celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill after 0.5 hour
Active carbon is added in extract liquor in extraction solution, filters after stirring half an hour decoloration immediately, removes active carbon and pigment, incited somebody to action
Celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill extract liquor after filter obtain 3 parts of traditional Chinese medicine extractions after being mixed by blender
Object；
S2, purified water is added in stirring container, then by 2 parts of vitamin Es, 4 parts of ascorbic acid, 5 parts of phosphatide and 1
Part Lactis Anhydrous is dissolved in 66 parts of purified waters, stirs to after being completely dissolved, be added 0.5 part of cannabidiol, 0.6 part of Propofol,
0.4 part of procaine hydrochloride and 3 parts of cosolvents are again stirring for being completely dissolved；
S3, the solution that completion is dissolved into S2 pour into mixing arrangement, and Chinese medical extract is then added to mixing arrangement
Interior by being stirred in stirring rod, manganese hydrogen sodium regulating solution pH is added in stirring after twenty minutes, and active carbon room temperature is then added
35min is adsorbed, carbon removal is filtered, it is spare with being placed after 0.22 μm of sterile filtering with microporous membrane degerming；
S4, it will be placed in S3 and carried out by bottle placer after spare solution sterilization filling, then sealing obtains after being packaged
Oral liquid medicine.
Embodiment 2
S1, it puts into pulverizer and carries out after celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill raw material are respectively washed removal of impurities
It crushes, then smashed raw material is respectively charged into digester, 80% concentration ethanol solution is added and is extracted, heats back
Stream 0.5 hour, temperature recycling design between 55 DEG C obtains celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill after 0.5 hour
Active carbon is added in extract liquor in extraction solution, filters after stirring half an hour decoloration immediately, removes active carbon and pigment, incited somebody to action
Celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill extract liquor after filter obtain 4 parts of traditional Chinese medicine extractions after being mixed by blender
Object；
S2, purified water is added in stirring container, then by 3 parts of vitamin Es, 6 parts of ascorbic acid, 8 parts of phosphatide and
0.5 part of Lactis Anhydrous is dissolved in 72 parts of purified waters, stirs to after being completely dissolved, and 0.5 part of cannabidiol, 0.6 part of third pool is added
Phenol, 0.2 part of procaine hydrochloride and 1 part of cosolvent are again stirring for being completely dissolved；
S3, the solution that completion is dissolved into S2 pour into mixing arrangement, and Chinese medical extract is then added to mixing arrangement
Interior by being stirred in stirring rod, manganese hydrogen sodium regulating solution pH is added in stirring after twenty minutes, and active carbon room temperature is then added
35min is adsorbed, carbon removal is filtered, it is spare with being placed after 0.22 μm of sterile filtering with microporous membrane degerming；
S4, it will be placed in S3 and carried out by bottle placer after spare solution sterilization filling, then sealing obtains after being packaged
Oral liquid medicine.
Embodiment 3
S1, it puts into pulverizer and carries out after celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill raw material are respectively washed removal of impurities
It crushes, then smashed raw material is respectively charged into digester, 80% concentration ethanol solution is added and is extracted, heats back
Stream 0.5 hour, temperature recycling design between 50 DEG C obtains celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill after 0.5 hour
Active carbon is added in extract liquor in extraction solution, filters after stirring half an hour decoloration immediately, removes active carbon and pigment, incited somebody to action
Celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill extract liquor after filter obtain 3.5 parts of traditional Chinese medicine extractions after being mixed by blender
Object；
S2, purified water is added in stirring container, then by 2.5 parts of vitamin Es, 5 parts of ascorbic acid, 6 parts of phosphatide and
0.7 part of Lactis Anhydrous is dissolved in 70 parts of purified waters, stirs to after being completely dissolved, and 0.8 part of cannabidiol, 0.7 part of third pool is added
Phenol, 0.3 part of procaine hydrochloride and 2 parts of cosolvents are again stirring for being completely dissolved；
S3, the solution that completion is dissolved into S2 pour into mixing arrangement, and Chinese medical extract is then added to mixing arrangement
Interior by being stirred in stirring rod, manganese hydrogen sodium regulating solution pH is added in stirring after twenty minutes, and active carbon room temperature is then added
35min is adsorbed, carbon removal is filtered, it is spare with being placed after 0.22 μm of sterile filtering with microporous membrane degerming；
S4, it will be placed in S3 and carried out by bottle placer after spare solution sterilization filling, then sealing obtains after being packaged
Oral liquid medicine.
Effect example
Clinical application to oral arcotic oral solution obtained by embodiment 1, embodiment 2 and embodiment 3: it randomly selects
40 patients test, men and women's number it is average be divided into example 1 group, 2 groups of embodiment, 3 groups of embodiment and control group, wherein female
Property patient 20, male patient 20, the crowd is observed continuously after test, records symptom and variation, obtain the result is that
Efficient in embodiment 1 is 94%, and is had no adverse reaction and apparent side effect, and efficient in embodiment 2 is 91%, and without bad
Reaction and apparent side effect, efficient in embodiment 3 is 97%, and is had no adverse reaction and apparent side effect, therefore is drawn a conclusion
It is best for oral anaesthetic preparation effect obtained in embodiment 3.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (7)
1. a kind of arcotic oral solution for gastric operation, it is characterised in that: its raw material includes: cannabidiol by weight
0.5 part -1 part, 0.6 part -0.8 part of Propofol, 3 parts -4 parts of Chinese medical extract, 0.2 part -0.4 part of procaine hydrochloride, vitamin E
2 parts -3 parts, 4 parts -6 parts of ascorbic acid, 0.5 part -1 part of sodium bicarbonate, 0.5 part -1 part of Lactis Anhydrous, -8 parts of phosphatidase 5 part, hydrotropy
1 part -3 parts and 66 parts -75 parts of purified water of agent.
2. a kind of arcotic oral solution for gastric operation according to claim 1, it is characterised in that: the Chinese medicine mentions
Object is taken to be made of Celastrus orbiculatus Thunb. Extract, Benzoinum extract, Huashan conopsea extraction and heroubill extract, and weight part ratio
Are as follows: 30 parts -35 parts of Celastrus orbiculatus Thunb. Extract, 35 parts -40 parts of Benzoinum extract, 10 parts -12 parts of Huashan conopsea extraction and heroubill
14 parts -20 parts of extract.
3. a kind of arcotic oral solution for gastric operation according to claim 1, it is characterised in that: the cosolvent
It is made of ethyl alcohol.
4. a kind of arcotic oral solution for gastric operation according to claim 1, it is characterised in that: described anti-oxidant
Agent is made of riboflavin.
5. a kind of arcotic oral solution for gastric operation according to any one of claims 1-4, it is characterised in that:
Preparation method specifically includes the following steps:
S1, it puts into after celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill raw material are respectively washed removal of impurities and carries out powder in pulverizer
It is broken, then smashed raw material is respectively charged into digester, 80% concentration ethanol solution is added and is extracted, thermal reflow
0.5-1.5 hours, temperature recycling design between 45-55 DEG C, obtained after 0.5-1.5 hours celastrus orbiculatus, styrax, Physochlaina macrophylla and
Active carbon is added in the extract liquor of heroubill in extraction solution, filters after stirring half an hour decoloration immediately, removes active carbon and color
Element obtains Chinese medicine after being mixed filtered celastrus orbiculatus, styrax, Physochlaina macrophylla and heroubill extract liquor by blender and mentions
Take object；
S2, purified water is added in stirring container, then by vitamin E, ascorbic acid, phosphatide, glyceride and Lactis Anhydrous
It is dissolved in purified water, stirs to after being completely dissolved, cannabidiol, Propofol, procaine hydrochloride, cosolvent and anti-oxidant is added
Agent is again stirring for being completely dissolved；
S3, the solution that completion is dissolved into S2 pour into mixing arrangement, and then Chinese medical extract is added in mixing arrangement and is led to
It crosses in stirring rod and is stirred, manganese hydrogen sodium regulating solution pH is added in stirring after twenty minutes, and the absorption of active carbon room temperature is then added
35min filters carbon removal, spare with placing after 0.22 μm of sterile filtering with microporous membrane degerming；
S4, it will be placed in S3 and carried out by bottle placer after spare solution sterilization filling, then sealing obtains oral after being packaged
Liquid medicament.
6. a kind of arcotic oral solution for gastric operation according to claim 5, it is characterised in that: add in the S1
The temperature of temperature reflux controls between 50-60 DEG C.
7. a kind of arcotic oral solution for gastric operation according to claim 5, it is characterised in that: salt in the S2
The form of sour procaine is powdery.
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| CN201910531541.XA CN110179888A (en) | 2019-06-19 | 2019-06-19 | A kind of arcotic oral solution and preparation method thereof for gastric operation |
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| CN201910531541.XA CN110179888A (en) | 2019-06-19 | 2019-06-19 | A kind of arcotic oral solution and preparation method thereof for gastric operation |
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Cited By (2)
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| CN113368084A (en) * | 2020-03-10 | 2021-09-10 | 上海喀露蓝科技有限公司 | Pharmaceutical composition containing cannabidiol, propofol prodrug and allopregnanolone prodrug compound and application of pharmaceutical composition in medicines |
| CN116159045A (en) * | 2021-11-24 | 2023-05-26 | 四川大学华西医院 | Application of cannabidiol and/or cannabidiol in preparation of local anesthetic efficacy enhancer |
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| CN105902681A (en) * | 2016-06-08 | 2016-08-31 | 雷知雅 | Oral local anesthetic preparation and preparation method thereof |
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| 张迎宪: "胡椒口服液复合丙泊酚-芬太尼静脉麻醉在无痛胃镜诊疗中的应用 ", 《中国中医急症》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113368084A (en) * | 2020-03-10 | 2021-09-10 | 上海喀露蓝科技有限公司 | Pharmaceutical composition containing cannabidiol, propofol prodrug and allopregnanolone prodrug compound and application of pharmaceutical composition in medicines |
| CN116159045A (en) * | 2021-11-24 | 2023-05-26 | 四川大学华西医院 | Application of cannabidiol and/or cannabidiol in preparation of local anesthetic efficacy enhancer |
| CN116159045B (en) * | 2021-11-24 | 2024-03-19 | 四川大学华西医院 | Application of cannabidiol and/or cannabidiol in preparation of local anesthetic efficacy enhancer |
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