CN110179866A - A kind of Chinese medicine ointment and preparation method thereof of tcm internal medicine treatment diarrhea - Google Patents
A kind of Chinese medicine ointment and preparation method thereof of tcm internal medicine treatment diarrhea Download PDFInfo
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- CN110179866A CN110179866A CN201910570701.1A CN201910570701A CN110179866A CN 110179866 A CN110179866 A CN 110179866A CN 201910570701 A CN201910570701 A CN 201910570701A CN 110179866 A CN110179866 A CN 110179866A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine ointment and preparation method thereof of tcm internal medicine treatment diarrhea.The present invention is made of the bulk pharmaceutical chemicals of following weight ratio: 15-25 parts of honeysuckle, 15-25 parts of tree of heaven ailanthus bark, 15-25 parts of huangteng, 10-13 parts of radix scutellariae, 10-15 parts of polygonum flaccidum, 10-12 parts of Fructus Forsythiae, 10-12 parts of folium artemisiae argyi, 5-10 parts of cimicifugae foetidae.Contain huangteng, honeysuckle and folium artemisiae argyi in traditional Chinese medicine of the present invention, there are good restraining and sterilizing bacteria and antiviral functions after being applied in combination, and functionally form synergy and complementation, to the Escherichia coli, staphylococcus, salmonella for causing diarrhea, streptococcus, shigella dysenteriae, typhoid bacillus etc. have stronger bacteriostasis.
Description
Technical field
The invention belongs to the Chinese medicine ointments and its preparation side of the field of Chinese medicines more particularly to a kind of tcm internal medicine treatment diarrhea
Method.
Background technique
Diarrhea is a kind of common sympton, is commonly called as " suffering from diarrhea ", refers to defecation frequency significantly more than the frequency being accustomed on ordinary days, excrement
Matter is thin, and moisture increases, and daily feces volume is more than 200g, or containing not digesting food or purulence blood, mucus.Diarrhea is often accompanied by defecation urgency
Compel the symptoms such as sense, anus discomfort, incontinence.Clinical manifestation be times of defecation increase, passage of loose stools and water and electrolyte disorder.
When treating diarrhea, medication beyond the region of objective existence of taking off mourning clothes generally takes the mode of venous transfusion to be treated, and exists to antibiotic
Therefore the case where abuse, treats diarrhea as most advantageous therapeutic modality using Chinese medicine mode, and the traditional mode of Chinese medicine is
Decoction is brewed into take, it is more inconvenient to take traditional Chinese herbal decoction for majority of populations, for diarrhea group,
Abilities of digestive and absorption is weaker, therefore, Chinese medicine ointment is made in Chinese drugs agentia and is spread at patient's navel, can effectively carry out to diarrhea
Treatment.
Summary of the invention
Aiming at the above shortcomings existing in the prior art, the purpose of the present invention is to provide a kind of tcm internal medicines to treat diarrhea
Chinese medicine ointment and preparation method thereof.
The present invention is the Chinese medicine medicine through the following technical solutions to achieve the above objectives: a kind of tcm internal medicine treatment diarrhea
Cream is made of the bulk pharmaceutical chemicals of following weight ratio: 15-25 parts of honeysuckle, 15-25 parts of tree of heaven ailanthus bark, 15-25 parts of huangteng, radix scutellariae 10-
13 parts, 10-15 parts of polygonum flaccidum, 10-12 parts of Fructus Forsythiae, 10-12 parts of folium artemisiae argyi, 5-10 parts of cimicifugae foetidae.
Further, it is made of the bulk pharmaceutical chemicals of following weight ratio: 20 parts of honeysuckle, 20 parts of tree of heaven ailanthus bark, 20 parts of huangteng, Huang
12 parts of a kind of reed mentioned in ancient books, 13 parts of polygonum flaccidum, 11 parts of Fructus Forsythiae, 11 parts of folium artemisiae argyi, 8 parts of cimicifugae foetidae.
Above-mentioned traditional Chinese medicine is prepared by the following method acquisition:
1) preextraction: above-listed bulk pharmaceutical chemicals are ground into coarse powder, are eluted 5-10 minutes with water, and water is added not have powder, adjust PH
It to 1.0~2.0, stands, filtering, adds purified water to appropriate, heating is boiled, and medical fluid is collected, and adjusts PH to 8.0~8.5, heating
It boils, collects in the medical fluid extracted twice before medical fluid is incorporated to.
2) be concentrated, purify: will be concentrated under reduced pressure through the medical fluid after step 1) preextraction, be added ethanol in proper amount adjusting alcoholic strength to
65~70 degree, PH to 4.5~6.5 is adjusted, is stood, supernatant liquid filtering is taken, recycles ethyl alcohol, then is primary with method progress alcohol precipitation purifying,
The mixed extract of above-listed bulk pharmaceutical chemicals is made after recycling ethyl alcohol.
3) be prepared into ointment: step 2) of learning from else's experience treated bulk pharmaceutical chemicals mixed extract is tuned into paste with ox glue, and stirring is equal
It is even, sterilization treatment is carried out, then booth is applied on non-woven fabrics, and packaging is labelled after vacuum sterilization.
Further, water described in step 1 is purified water.
Further, pH value is adjusted with 10% sodium hydroxide solution or 10% sulfuric acid solution in step 2.
Further, sterilizing 30 minutes is carried out in step 3 at a temperature of 100 DEG C -110 DEG C.
Compared with prior art, the beneficial effects of the present invention are:
1, a kind of Chinese medicine ointment of tcm internal medicine treatment diarrhea of the present invention, has good restraining and sterilizing bacteria and antiviral function
Can, and synergy and complementation are functionally formed, to the Escherichia coli, staphylococcus, salmonella for causing diarrhea, streptococcus,
Shigella dysenteriae, typhoid bacillus etc. have stronger bacteriostasis.
2, a kind of Chinese medicine ointment of tcm internal medicine treatment diarrhea of the present invention, keeps the therapeutic effect of relieving diarrhea with astringents and hemostasis obvious
Enhancing, and duration of efficacy extends, and gastrointestinal tract inflammation position and ulcer surface can be made to obtain fast quick-recovery, healing time is obvious
Shorten.
3, a kind of Chinese medicine ointment of tcm internal medicine treatment diarrhea of the present invention, regulating qi-flowing for relieving pain, reconciliation stomach, inducing diaphoresis dehumidifying are extensive
It answers a pager's call body autoimmune function, improves the absorption rate of drug.
4, a kind of Chinese medicine ointment of tcm internal medicine treatment diarrhea of the present invention, is made, significant in efficacy, composition of pure Chinese herbal medicine
Rationally, dosage is few, environmentally protective, easy to operate, significant in efficacy, few side effects.
The present invention makes each efficacy of drugs generate synergistic effect after selecting pharmaceutical composition, from antibacterial, sterilization, antiviral and receipts
Hold back, relieving diarrhea with astringents, three aspects such as hemostasis and middle benefit gas stomach invigorating, regulating qi-flowing for relieving pain carry out complex treatments and conditioning, reach treating both manifestation and root cause of disease
Effect, not only significant in efficacy, cure rate is high, and utilization ratio of drug is high, and healing time is short, and raw material is easy to get, simple production process, at
This is cheap, and bulk pharmaceutical chemicals of the present invention are homologous, androgynous with plant, are general chemicals, antibiotic, hormone medicine etc.
Incomparable, metabolite directly can be absorbed or be excreted by animal, and noresidue has no drug resistance, and will not be to ring
Border causes damages.
The pharmacological effect of each component of the present invention is as follows:
1, honeysuckle has effects that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treats wind.Cure mainly disease under turgor, warm disease heating, heat toxin carbuncle
The diseases such as ulcer and tumour.
2, tree of heaven ailanthus bark, it is bitter in taste, cold, puckery, have except heat, eliminating dampness, puckery intestines, hemostasis, desinsection special efficacy.To enteritis, dysentery with bloody stool,
The alimentary canals inflammatory disease such as enterorrhagia has good effect.Heat-clearing and damp-drying drug, puckery intestines, hemostasis, stop-band, desinsection, main diarrhea, dysentery, hematochezia collapse
Leakage, hemorrhoid hemorrhage, leukorrhagia, ascariasis, ringworm sore.Channel tropism: stomach；Large intestine；The heart；Liver；Spleen；Lung channel.
3, huangteng has effects that clearing heat and detoxicating, antibacterial anti-inflammatory, antiviral, diuresis, to the large intestine for causing scouring
The various bacterias such as bacillus, staphylococcus, streptococcus, shigella dysenteriae, typhoid bacillus and virus have stronger bacteriostasis.
4, radix scutellariae has heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention and other effects.Cure mainly warm heat disease, the infection of the upper respiratory tract,
The diseases such as cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, threatened abortion, hypertension, carbuncle swells furuncle sore.
5, polygonum flaccidum has effects that dry antidiarrheal, removing blood stasis and acesodyne, wind-dispelling, pesticide-germicide, cures mainly dysentery abdominal pain, cold intestines are let out
It rushes down, the symptoms such as dysentery of trembling with fear.
6, Fructus Forsythiae has heat-clearing, removing toxic substances, dissipating bind, detumescence.Control warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching
It closes.
7, folium artemisiae argyi, pungent, bitter, temperature.Warming channel for arresting bleeding, eliminating cold to stop pain；External application removing dampness to stop itchin.For spitting blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia and metrostaxis, the moon
Through excessive, blood under vaginal bleeding during pregnancy, abdomen crymodynia are uncomfortable through trembling with fear, uterus cold infertile；Pruitus is controlled outside.Vinegar Chinese mugwort charcoal warming channel for arresting bleeding, for void
Cold bleeding.
8, cimicifugae foetidae, it is pungent, sweet, it is slightly cold.Promoting eruption is delivered, clearing heat and detoxicating, yang invigorating.When gas plague, have a headache fever and chills, laryngalgia,
Aphtha, macula are impermeable；The sinking of qi of middle-jiao, protracted dysentery and diarrhea, rectal prolapse, women collapses, band, uterus tenesmus；Carbuncle sore tumefacting virus.
Suggested use and dosage of the invention:
Made ointment is affixed on navel, replacement in 24 hours is primary, general 2-3 visible positive effect.
Specific embodiment
Below by way of specific embodiment, the present invention is further explained, but is not limited to following embodiments.
Embodiment 1
A kind of Chinese medicine ointment of tcm internal medicine treatment diarrhea, is made: 20 parts of honeysuckle, the tree of heaven of the bulk pharmaceutical chemicals of following weight ratio
20 parts of white skin, 20 parts of huangteng, 12 parts of radix scutellariae, 13 parts of polygonum flaccidum, 11 parts of Fructus Forsythiae, 11 parts of folium artemisiae argyi, 8 parts of cimicifugae foetidae, the traditional Chinese medicine
It is prepared by the following method acquisition:
1) preextraction: after above-mentioned Chinese medicine material is mixed, being ground into the coarse powder of 25 meshes, is placed in multi-functional traditional Chinese medicine extraction
It in tank, is eluted 5~10 minutes with purified water, purified water is added not have powder, adjust PH to 1.0~2.0 with 10% sulfuric acid solution, it is quiet
Set 12 hours, add appropriate purified water, heating boils 2 times, and 30 minutes every time, it was spare to collect medical fluid, after again plus purified water does not have
Powder is crossed, adjusts PH to 8.0~8.5 with 10% sodium hydroxide solution, heating is boiled 30 minutes, is collected before medical fluid is incorporated to and is mentioned twice
In taking liquid.
2) it is concentrated, purifies: the medical fluid after step 1) preextraction is concentrated under reduced pressure into one of five parts of stoste, be added appropriate
Ethyl alcohol adjust alcoholic strength to 65 degree or 70 degree, with 10% sodium hydroxide solution or 10% sulfuric acid solution adjusting PH to 4.5~6.5,5
It stands 24 hours at~8 DEG C, takes supernatant liquid filtering, recycle ethyl alcohol, then carry out alcohol precipitation purifying once with method, after recycling ethyl alcohol to obtain the final product
The mixed extract of above-mentioned 7 taste Chinese medicine.
3) prepare injection: step 2) of learning from else's experience treated Chinese medicine mixed extract is tuned into paste with ox glue, and stirring is equal
It is even, sterilizing 30 minutes is carried out at a temperature of 100 DEG C -110 DEG C, then booth is applied on non-woven fabrics, and packaging is labelled after vacuum sterilization.
Embodiment 2
A kind of Chinese medicine ointment of tcm internal medicine treatment diarrhea, is made: 15 parts of honeysuckle, the tree of heaven of the bulk pharmaceutical chemicals of following weight ratio
15 parts of white skin, 15 parts of huangteng, 10 parts of radix scutellariae, 10 parts of polygonum flaccidum, 10 parts of Fructus Forsythiae, 10 parts of folium artemisiae argyi, 5 parts of cimicifugae foetidae, the traditional Chinese medicine
It is prepared by the following method acquisition:
1) preextraction: after above-mentioned Chinese medicine material is mixed, being ground into the coarse powder of 25 meshes, is placed in multi-functional traditional Chinese medicine extraction
It in tank, is eluted 5~10 minutes with purified water, purified water is added not have powder, adjust PH to 1.0~2.0 with 10% sulfuric acid solution, it is quiet
Set 12 hours, add appropriate purified water, heating boils 2 times, and 30 minutes every time, it was spare to collect medical fluid, after again plus purified water does not have
Powder is crossed, adjusts PH to 8.0~8.5 with 10% sodium hydroxide solution, heating is boiled 30 minutes, is collected before medical fluid is incorporated to and is mentioned twice
In taking liquid.
2) it is concentrated, purifies: the medical fluid after step 1) preextraction is concentrated under reduced pressure into one of five parts of stoste, be added appropriate
Ethyl alcohol adjust alcoholic strength to 65 degree or 70 degree, with 10% sodium hydroxide solution or 10% sulfuric acid solution adjusting PH to 4.5~6.5,5
It stands 24 hours at~8 DEG C, takes supernatant liquid filtering, recycle ethyl alcohol, then carry out alcohol precipitation purifying once with method, after recycling ethyl alcohol to obtain the final product
The mixed extract of above-mentioned 7 taste Chinese medicine.
3) prepare injection: step 2) of learning from else's experience treated Chinese medicine mixed extract is tuned into paste with ox glue, and stirring is equal
It is even, sterilizing 30 minutes is carried out at a temperature of 100 DEG C -110 DEG C, then booth is applied on non-woven fabrics, and packaging is labelled after vacuum sterilization.
Embodiment 3
A kind of Chinese medicine ointment of tcm internal medicine treatment diarrhea, is made: 25 parts of honeysuckle, the tree of heaven of the bulk pharmaceutical chemicals of following weight ratio
25 parts of white skin, 25 parts of huangteng, 13 parts of radix scutellariae, 15 parts of polygonum flaccidum, 12 parts of Fructus Forsythiae, 12 parts of folium artemisiae argyi, 10 parts of cimicifugae foetidae, the traditional Chinese medicine
It is prepared by the following method acquisition:
1) preextraction: after above-mentioned Chinese medicine material is mixed, being ground into the coarse powder of 25 meshes, is placed in multi-functional traditional Chinese medicine extraction
It in tank, is eluted 5~10 minutes with purified water, purified water is added not have powder, adjust PH to 1.0~2.0 with 10% sulfuric acid solution, it is quiet
Set 12 hours, add appropriate purified water, heating boils 2 times, and 30 minutes every time, it was spare to collect medical fluid, after again plus purified water does not have
Powder is crossed, adjusts PH to 8.0~8.5 with 10% sodium hydroxide solution, heating is boiled 30 minutes, is collected before medical fluid is incorporated to and is mentioned twice
In taking liquid.
2) it is concentrated, purifies: the medical fluid after step 1) preextraction is concentrated under reduced pressure into one of five parts of stoste, be added appropriate
Ethyl alcohol adjust alcoholic strength to 65 degree or 70 degree, with 10% sodium hydroxide solution or 10% sulfuric acid solution adjusting PH to 4.5~6.5,5
It stands 24 hours at~8 DEG C, takes supernatant liquid filtering, recycle ethyl alcohol, then carry out alcohol precipitation purifying once with method, after recycling ethyl alcohol to obtain the final product
The mixed extract of above-mentioned 7 taste Chinese medicine.
3) prepare injection: step 2) of learning from else's experience treated Chinese medicine mixed extract is tuned into paste with ox glue, and stirring is equal
It is even, sterilizing 30 minutes is carried out at a temperature of 100 DEG C -110 DEG C, then booth is applied on non-woven fabrics, and packaging is labelled after vacuum sterilization.
Made ointment is affixed on navel, replacement in 24 hours is primary, general 2-3 visible positive effect.
During specifically used 10 years, up to ten thousand diarrhea abdomen cases are treated altogether, and cure rate reaches 90% or more.The present invention
For treatment diarrhea ointment, all it is made of pure Chinese medicine, it is without side-effects.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not whole embodiments of the invention, not to limit
The system present invention, all within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in
Within protection scope of the present invention.
In addition to the technical characteristic described in the specification, remaining technical characteristic is technology known to those skilled in the art, in order to prominent
Innovative characteristics of the invention out, details are not described herein for above-mentioned technical characteristic.
Claims (6)
1. a kind of Chinese medicine ointment of tcm internal medicine treatment diarrhea, which is characterized in that be made of the bulk pharmaceutical chemicals of following weight ratio: gold and silver
15-25 parts of flower, 15-25 parts of tree of heaven ailanthus bark, 15-25 parts of huangteng, 10-13 parts of radix scutellariae, 10-15 parts of polygonum flaccidum, 10-12 parts of Fructus Forsythiae, Chinese mugwort
10-12 parts of leaf, 5-10 parts of cimicifugae foetidae.
2. the Chinese medicine ointment of tcm internal medicine treatment diarrhea according to claim 1, which is characterized in that by following weight ratio
Bulk pharmaceutical chemicals are made: 20 parts of honeysuckle, 20 parts of tree of heaven ailanthus bark, 20 parts of huangteng, 12 parts of radix scutellariae, 13 parts of polygonum flaccidum, 11 parts of Fructus Forsythiae, folium artemisiae argyi 11
Part, 8 parts of cimicifugae foetidae.
3. the preparation method of the Chinese medicine ointment of tcm internal medicine treatment diarrhea according to claim 1 or 2, which is characterized in that
The following steps are included:
1) preextraction: above-listed bulk pharmaceutical chemicals are ground into coarse powder, are eluted 5-10 minutes with water, and water is added not have powder, adjust PH to 1.0
~2.0, it stands, filtering adds purified water to appropriate, and heating is boiled, and collects medical fluid, adjusts PH to 8.0~8.5, and heating is boiled,
It collects in the medical fluid extracted twice before medical fluid is incorporated to.
2) it is concentrated, purifies: will be concentrated under reduced pressure through the medical fluid after step 1) preextraction, addition ethanol in proper amount adjusting alcoholic strength to 65~
70 degree, PH to 4.5~6.5 is adjusted, is stood, supernatant liquid filtering is taken, recycles ethyl alcohol, then carry out alcohol precipitation with method and purify primary, recycling
The mixed extract of above-listed bulk pharmaceutical chemicals is made after ethyl alcohol.
3) be prepared into ointment: step 2) of learning from else's experience treated bulk pharmaceutical chemicals mixed extract is tuned into paste with ox glue, stirs evenly,
Sterilization treatment is carried out, then booth is applied on non-woven fabrics, and packaging is labelled after vacuum sterilization.
4. the preparation method of the Chinese medicine ointment of tcm internal medicine treatment diarrhea according to claim 3, which is characterized in that step
Water described in 1 is purified water.
5. the preparation method of the Chinese medicine ointment of tcm internal medicine treatment diarrhea according to claim 3, which is characterized in that step
PH value is adjusted with 10% sodium hydroxide solution or 10% sulfuric acid solution in 2.
6. the preparation method of the Chinese medicine ointment of tcm internal medicine treatment diarrhea according to claim 3, which is characterized in that step
Sterilizing 30 minutes is carried out in 3 at a temperature of 100 DEG C -110 DEG C.
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Application publication date: 20190830 |