CN110167593A - 用于治疗或预防干扰素-γ相关适应症的方法、组合物和给药方案 - Google Patents

用于治疗或预防干扰素-γ相关适应症的方法、组合物和给药方案 Download PDF

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CN110167593A
CN110167593A CN201780080221.6A CN201780080221A CN110167593A CN 110167593 A CN110167593 A CN 110167593A CN 201780080221 A CN201780080221 A CN 201780080221A CN 110167593 A CN110167593 A CN 110167593A
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acid sequence
dosage
seq
antibody
amino acid
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Chinese (zh)
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C.德敏
W.费尔林
F.德贝内德蒂
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Novimmune SA
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Novimmune SA
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249Interferons
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Chemical & Material Sciences (AREA)
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  • Immunology (AREA)
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Biotechnology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201780080221.6A 2016-10-24 2017-10-24 用于治疗或预防干扰素-γ相关适应症的方法、组合物和给药方案 Pending CN110167593A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662411783P 2016-10-24 2016-10-24
US62/411783 2016-10-24
PCT/IB2017/001427 WO2018078442A2 (en) 2016-10-24 2017-10-24 Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications

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Publication Number Publication Date
CN110167593A true CN110167593A (zh) 2019-08-23

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CN201780080221.6A Pending CN110167593A (zh) 2016-10-24 2017-10-24 用于治疗或预防干扰素-γ相关适应症的方法、组合物和给药方案

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EP (1) EP3528845A2 (pt)
JP (2) JP2019532970A (pt)
KR (1) KR20190071785A (pt)
CN (1) CN110167593A (pt)
AU (1) AU2017352033A1 (pt)
BR (1) BR112019008156A2 (pt)
CA (1) CA3041434A1 (pt)
EA (1) EA201990930A1 (pt)
IL (1) IL266174B1 (pt)
MX (1) MX2019004766A (pt)
SG (1) SG11201903659WA (pt)
WO (1) WO2018078442A2 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108884459A (zh) * 2016-04-26 2018-11-23 科济生物医药(上海)有限公司 一种改善免疫应答细胞功能的方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3488851A1 (en) * 2018-10-03 2019-05-29 AVM Biotechnology, LLC Immunoablative therapies
WO2021185832A1 (en) 2020-03-16 2021-09-23 Swedish Orphan Biovitrum Ag New therapeutic treatment

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN101151277A (zh) * 2005-01-27 2008-03-26 诺维莫尼公司 抗干扰素γ抗体及其使用方法
CN104159919A (zh) * 2011-11-23 2014-11-19 安姆根有限公司 使用抗干扰素γ抗体的治疗方法

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US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US6329511B1 (en) * 1998-12-01 2001-12-11 Protein Design Labs, Inc. Humanized antibodies to γ-interferon
CA2985001A1 (en) * 2015-05-07 2016-11-10 Novimmune Sa Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of cxcl9 and other biomarkers

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN101151277A (zh) * 2005-01-27 2008-03-26 诺维莫尼公司 抗干扰素γ抗体及其使用方法
CN104159919A (zh) * 2011-11-23 2014-11-19 安姆根有限公司 使用抗干扰素γ抗体的治疗方法

Non-Patent Citations (14)

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Title
C BRACAGLIA等: "Anti interferon-gamma (IFNg) monoclonal antibody treatment in a patient carrying an NLRC4 mutation and severe hemophagocytic lymphohistiocytosis", 《PEDIATRIC RHEUMATOLOGY》, vol. 13, no. 1, 28 September 2015 (2015-09-28), pages 1 - 2 *
C BRACAGLIA等: "Anti interferon-gamma (IFNg) monoclonal antibody treatment in a patient carrying an NLRC4 mutation and severe hemophagocytic lymphohistiocytosis", 《PEDIATRIC RHEUMATOLOGY》, vol. 13, pages 1 - 2 *
CLINICALTRIALS: "NCT01818492", 《CLINICALTRIALS》 *
CLINICALTRIALS: "NCT01818492", 《CLINICALTRIALS》, 14 July 2016 (2016-07-14) *
CRISTINA DE MIN等: "Innovative Approach for the Identification of an Appropriate Dose Regimen of a Targeted Treatment, NI-0501, an Anti-Interferon Gamma(IFNg)Antibody, in Patients with Hemophagocytic Lymphohistiocytosis(HLH)", 《ACR MEETING ABSTRACTS》, 29 September 2015 (2015-09-29), pages 1 - 2 *
CRISTINA DE MIN等: "Innovative Approach for the Identification of an Appropriate Dose Regimen of a Targeted Treatment, NI-0501, an Anti-Interferon Gamma(IFNg)Antibody, in Patients with Hemophagocytic Lymphohistiocytosis(HLH)", 《ACR MEETING ABSTRACTS》, pages 226 - 227 *
EMA/COMP: "Public summary of opinion on orphan designation Recombinant human anti-interferon gamma monoclonal antibody for the treatment of haemophagocytic lymphohistiocytosis", 《EMA/COMP》 *
EMA/COMP: "Public summary of opinion on orphan designation Recombinant human anti-interferon gamma monoclonal antibody for the treatment of haemophagocytic lymphohistiocytosis", 《EMA/COMP》, 10 June 2010 (2010-06-10) *
M. B. JORDAN 等: "How I treat hemophagocytic lymphohistiocytosis", 《BLOOD》 *
M. B. JORDAN 等: "How I treat hemophagocytic lymphohistiocytosis", 《BLOOD》, 13 October 2011 (2011-10-13) *
SUMIT GOSWAMI等: "Developments and Challenges for mAb-Based Therapeutics", 《ANTIBODIES》, vol. 2, no. 3, pages 452 - 500, XP055128980, DOI: 10.3390/antib2030452 *
SUMIT GOSWAMI等: "Developments and Challenges for mAb-Based Therapeutics:Developments and Challenges for mAb-Based Therapeutics", 《ANTIBODIES》, vol. 2, no. 3, 16 August 2013 (2013-08-16), pages 452 - 500, XP055128980, DOI: 10.3390/antib2030452 *
USMANI GN等: "Advances in understanding the pathogenesis of HLH", 《BRITISH JOURNAL OF HAEMATOLOGY》, vol. 161, no. 5, pages 609 - 622, XP071120958, DOI: 10.1111/bjh.12293 *
USMANI GN等: "Advances in understanding the pathogenesis of HLH:Advances in understanding the pathogenesis of HLH", 《BRITISH JOURNAL OF HAEMATOLOGY》, vol. 161, no. 5, 12 April 2013 (2013-04-12), pages 609 - 622, XP071120958, DOI: 10.1111/bjh.12293 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108884459A (zh) * 2016-04-26 2018-11-23 科济生物医药(上海)有限公司 一种改善免疫应答细胞功能的方法
CN108884459B (zh) * 2016-04-26 2024-04-02 科济生物医药(上海)有限公司 一种改善免疫应答细胞功能的方法

Also Published As

Publication number Publication date
AU2017352033A1 (en) 2019-06-06
EA201990930A1 (ru) 2019-11-29
CA3041434A1 (en) 2018-05-03
KR20190071785A (ko) 2019-06-24
WO2018078442A3 (en) 2018-08-23
IL266174A (en) 2019-06-30
JP2022187025A (ja) 2022-12-15
IL266174B1 (en) 2024-06-01
WO2018078442A2 (en) 2018-05-03
MX2019004766A (es) 2019-09-27
JP2019532970A (ja) 2019-11-14
BR112019008156A2 (pt) 2019-07-02
EP3528845A2 (en) 2019-08-28
SG11201903659WA (en) 2019-05-30

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