CN110151856A - Soapberry is preparing the application in anti-shield infusorian drug - Google Patents
Soapberry is preparing the application in anti-shield infusorian drug Download PDFInfo
- Publication number
- CN110151856A CN110151856A CN201910529470.XA CN201910529470A CN110151856A CN 110151856 A CN110151856 A CN 110151856A CN 201910529470 A CN201910529470 A CN 201910529470A CN 110151856 A CN110151856 A CN 110151856A
- Authority
- CN
- China
- Prior art keywords
- shield
- soapberry
- turbot
- infusorian
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Abstract
The invention discloses soapberrys to prepare the application in anti-shield infusorian drug.The invention belongs to pharmaceutical technology fields.Soapberry can be made powder, be added in feed with any acceptable auxiliary material, and the turbot of shield infusorian disease is suffered from feeding；Or soapberry is subjected to ethyl alcohol extraction, addition auxiliary material is prepared into liquid, and the turbot of shield infusorian disease is suffered from dipping.Present invention firstly discovers that soapberry can significantly reduce the death rate of turbot shield balantidiasis, the ciliophoran infection rate of shield is reduced.
Description
Technical field
The invention belongs to pharmaceutical technology fields.The present invention relates to a kind of new opplications of Chinese medicine, and in particular to soapberry exists
Prepare the application in anti-shield infusorian drug.
Background technique
Turbot (Scophthalmus maximus), also known as more precious fishes, NATURAL DISTRIBUTION is in Eastern Atlantic to northeast
European coast, battalion dwells life at bottom.Since introducing China, good economic benefit is created, artificial breeding has become me
One of mainstay industry of state's sea-farming.However, with turbot cultivation density be continuously increased and disease control study
Lag, causes various culture diseases to come one after another.In various culture diseases, by shield infusorian, cryptonucleus insect, Trichodina or flagellum
Parasitic disease caused by worm etc. causes massive losses to turbot aquaculture, wherein shield balantidiasis can cause fast-killing
Systemic infection, harm is maximum.
Turbot disease caused by shield infusorian (Paralembus digitiformis) has contagiousness strong, harmfulness
Big feature, especially seed, which are once fallen ill, to bring about great losses to raiser.The turbot for suffering from shield balantidiasis is general
Daily death rate 0.5%-2%, cumulative mortality reach 20%-30%, and serious person is up to 70% or more.Cause of disease be mainly crab dwell it is different
Ah brain worm can cause to fall ill into cultivating system through a variety of ways.Shield infusorian be not only largely present in turbot affected part,
Body surface, the cheek also largely see liver,spleen,kidney, brain, the heart, while largely seeing ascites.Initial infection, sick fish body table occur hickie,
Mucus increases, and as redness occurs in the development affected area tissue of the state of an illness, has soft edema sense, the skin of trunk of fish when serious
It will appear lesion, until festering, bleeding.The general body colour of illness fish is dimmed, and vigor weakens, and food ration reduces, decreased growth；It is supporting
It grows and dissipates group in pond, occur the motility that spins often.Infusorian can infect most of internal organs including brain tissue.
At present the effective ways of domestic treatment shield Infusoria disease are few, in actual production, disease in order to prevent
Occurring, antibiotic and chemosterilant are usually utilized to treatment fish body disease, but since cultivation dealer lacks healthy aquaculture consciousness,
Blindly large dosage of Reusability antibiotic and chemosterilant or even many illegal drugs use repeatedly, and fish body is caused to measure greatly
Existing medicament residue phenomenon, causing aquatic products, there are serious security risks.For taking place frequently for balantidiasis harm, the country is mainly adopted
The generation of the disease is prevented and treated with formaldehyde, copper sulphate etc., or even the treatment for thering is raiser to carry out infusorian disease using violated pesticide.
But pesticide and chemicals are used for a long time, not only pollute environment, also become the Green Trade Barrier problem of current product water outlet,
Therefore novel, safe and environment-friendly insecticidal materials are found as the task of top priority.
Soapberry (Classification system: Sapindus mukorossi Gaertn.), alias: wood suffers from sub (Compendium of Materia Medica),
He has local name: rubbing mesh, false longan, Devil Frown etc. with the hands.Pericarp contains saponin, can do boxboard and wooden comb etc. for soap, timber；
Root, browse, seed: bitter, micro-pungent is trembled with fear, slightly poisonous.For diphtheria, abscess of throat, acute tonsillitis, cough, pertussis, food stagnation malnutrition due to parasitic infestation.
" sward pharmacological property standby will ", which records soapberry, has hemostasis；Simmer food desinsection, eliminating greasiness；Boil plaster wind-dispelling, detumescence, detoxification.Ancient times are used for
Oral ascarifuge.
In aquatic products insecticidal materials, pest-resistant drug has no broad spectrum disinfestation drug.Moreover, studies have shown that same drug is not to
The Resistant Difference of same helminth is larger, well kills effect as ivermectin has nematode and arthropod, but to silk ribbon
Worm, fluke and protozoan are invalid.By a large amount of screening tests of early period, the results showed that, expelling parasite work is recorded in many documents
Drug to shield infusorian and to no effect, such as: ivermectin is recorded in document, mebendazole has pest-resistant effect, still
It is to shield infusorian and to no effect.It proves that a drug has anti-shield infusorian effect, needs just be tied through overtesting
Fruit.There is not been reported for the ciliophoran effect of the shield of the anti-turbot of soapberry, and by soapberry available data, it is anti-can not to conclude that it has
The effect of shield infusorian.
Summary of the invention
This project group, which is passed through, kills shield infusorian effect expedition to 1000 plurality of Chinese, and screening, which obtains tens, has anti-fibre
The Chinese herbal medicine of caterpillar drug, the present invention are that we kill one of the achievement of shield infusorian drug screening project.
The present invention provides soapberrys to prepare the application in anti-shield infusorian drug.
Advantages of the present invention is as follows:
(1) feeding of turbot is not influenced；
(2) without medicament residue in turbot body, no security risk has ensured the food safety of the people；
(3) environmentally friendly, avoid the pollution to ocean such as breeding process formaldehyde emission, copper sulphate and violated pesticide.
The present invention is realized by following technical solutions:
Inventor is added in feed, mixes, by daily feeding by the way that powder is made by soapberry and acceptable auxiliary material
Doses feeding turbot, the additive amount of soapberry medicinal material are that 100g soapberry medicinal material powder is added in every 100kg feed；Or take nothing
Suffer from sub- 200g, after ethyl alcohol extracts, extracting solution is splashed into 1000kg water, carries out the dipping of illness turbot.By dynamic
Object infection experiment confirms that addition soapberry can be such that turbot shield infusorian infection rate, the death rate is substantially reduced, and has preferable anti-
The effect of shield infusorian.
Specific embodiment
By the following example more specific description present invention, the technical staff of the industry it is to be appreciated that the present invention not by
The limitation of cited embodiment, the example is merely to the model for illustrating the present invention, rather than limiting the invention in any way
It encloses.Without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes and improvements
It all fall within the protetion scope of the claimed invention.
The preparation of 1 soapberry powder of embodiment: taking 100g soapberry medicinal material, and 20g anticaking agent is added, and crushes, and crosses 200 meshes
Net.
The usage and dosage of powder: above-mentioned 100g powder is admixed in 100kg feed, per diem often feeding amount feeding.
The preparation of 2 soapberry liquid preparation of embodiment: taking 200g soapberry medicinal material, and the food-grade ethanol of 10 times of amounts is added,
70 DEG C of heating, Soakage extraction is finally concentrated to 500ml.
The dosage of soapberry alcohol extract: soapberry alcohol extract 500ml is taken, is splashed into 1000kg seawater, is suffered from
The dipping of shield balantidiasis turbot.
Illustrate the anti-shield infusorian effect of soapberry below with reference to specific test.
One, the drug effect of 2 pairs of embodiment prevention and treatment turbot shield balantidiasis is observed.
Turbot attacks malicious model construction: taking the shield infusorian larva of exponential phase of growth for attacking poison.With wire gauze cloth in big water chestnut
Flounder (weight about 200g) muscle of back goes out the scratch area of 2cm × 2cm that rubs, and polypide, water body of breeding fish is added according to about 50000/L
30L, 12 DEG C of water temperature, oxygenation normally feeds turbot.Change at observation ulcer daily, mucus or group are gently scraped from wound
It is woven in microscopically observation to take pictures and count, infection established turbot shield infusorian disease after 2 days.
Dipping test: dividing three groups, and first group is control group: illness group without any processing, totally 50 tail；Second group is positive
50% test group of normal soapberry dosage: embodiment 2 is splashed into 2000kg seawater, daily dipping 30min, and totally 50
Tail；Third group is normal soapberry dosage group: embodiment 2 splashed into 1000kg seawater, daily dipping 30min, altogether
50 tails；4th group of 2 times of test groups for soapberry normal use dosage splash embodiment 2 into 500kg seawater, daily
Dipping 30min, totally 50 tail.Test result observation gently scrapes test group and control group disease sites by oese, micro-
Microscopic observation infusorian vigor, and in the infusorian quantity of microscopically observation turbot body surface.Test 5 days.
The result shows that first group of the turbot death rate is 36%, the ciliophoran infection of the shield of turbot after dipping 5 days
Rate is 60%, and second group of the turbot death rate is 31%, and the ciliophoran infection rate of the shield of turbot is 43%.Third group
The turbot death rate is 16%, and the ciliophoran infection rate of the shield of turbot is 26%.4th group of the turbot death rate is 18%,
The ciliophoran infection rate of the shield of turbot is 23%.The result shows that soapberry has treatment turbot shield infusorian disease well
The effect of disease.
Two, the drug effect of 1,2 pair of embodiment prevention and treatment turbot natural infection shield balantidiasis is observed.
In December, 2017 in November, 2018, this invention content break out shield balantidiasis on Weifang, Xingcheng, Suizhong and other places
Turbot farm carried out pharmacodynamic test, demonstrate the curative effect of the invention.See Table 1 for details for the treatment condition of each farm.
1. soapberry of table is to the ciliophoran control efficiency clinical analysis of turbot shield
Multiple clinical test results show that soapberry has significant curative effect in terms of preventing and treating turbot shield infusorian disease,
The death rate and infection rate of turbot shield infusorian disease can be reduced, the chemicals such as effect and formaldehyde, copper sulphate are suitable, and
And it is safer, it has ensured food safety, the feeding of fish will not be caused to significantly affect, the growth of turbot is not influenced, reduce
The economic loss of raiser.Meanwhile reducing the use of the chemical drugs such as formaldehyde, copper sulphate, have more to the environmental protection of ocean
Profound significance.
Claims (2)
1. soapberry is preparing the application in anti-shield infusorian drug or feed addictive.
2. soapberry is preparing the application in anti-shield infusorian drug or feed addictive as sole active agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910529470.XA CN110151856A (en) | 2019-06-19 | 2019-06-19 | Soapberry is preparing the application in anti-shield infusorian drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910529470.XA CN110151856A (en) | 2019-06-19 | 2019-06-19 | Soapberry is preparing the application in anti-shield infusorian drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110151856A true CN110151856A (en) | 2019-08-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910529470.XA Pending CN110151856A (en) | 2019-06-19 | 2019-06-19 | Soapberry is preparing the application in anti-shield infusorian drug |
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| Country | Link |
|---|---|
| CN (1) | CN110151856A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115444853A (en) * | 2022-10-25 | 2022-12-09 | 宁波大学 | Method for preventing and treating pathogenic ciliates of aquatic animals |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998319A (en) * | 2016-06-17 | 2016-10-12 | 江苏农牧科技职业学院 | Application of Chinese soapberry fruits to preparing of medicine for treating livestock-poultry viral infectious diseases |
| CN106490334A (en) * | 2016-12-09 | 2017-03-15 | 黄文庆 | Chinese medicine composition of preventing and treating fish parasites and preparation method thereof |
-
2019
- 2019-06-19 CN CN201910529470.XA patent/CN110151856A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998319A (en) * | 2016-06-17 | 2016-10-12 | 江苏农牧科技职业学院 | Application of Chinese soapberry fruits to preparing of medicine for treating livestock-poultry viral infectious diseases |
| CN106490334A (en) * | 2016-12-09 | 2017-03-15 | 黄文庆 | Chinese medicine composition of preventing and treating fish parasites and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115444853A (en) * | 2022-10-25 | 2022-12-09 | 宁波大学 | Method for preventing and treating pathogenic ciliates of aquatic animals |
| CN115444853B (en) * | 2022-10-25 | 2023-08-04 | 宁波大学 | Method for preventing and controlling pathogenic ciliates of aquatic animals |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 102600 No. 44, Yongda Road, Daxing biomedical industry base, Zhongguancun Science Park, Daxing District, Beijing Applicant after: BEIJING CENTRE BIOLOGY Co.,Ltd. Address before: No. 2354, block B, No. 9, Chaoqian Road, science and Technology Park, Changping District, Beijing 102206 Applicant before: BEIJING CENTRE BIOLOGY Co.,Ltd. |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190823 |
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| RJ01 | Rejection of invention patent application after publication |