CN110146492A - Flow path system and light-induced chemiluminescent analyzer - Google Patents
Flow path system and light-induced chemiluminescent analyzer Download PDFInfo
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- CN110146492A CN110146492A CN201810142680.9A CN201810142680A CN110146492A CN 110146492 A CN110146492 A CN 110146492A CN 201810142680 A CN201810142680 A CN 201810142680A CN 110146492 A CN110146492 A CN 110146492A
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- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 144
- 239000007788 liquid Substances 0.000 claims abstract description 135
- 239000002699 waste material Substances 0.000 claims abstract description 91
- 238000004140 cleaning Methods 0.000 claims abstract description 44
- 238000005554 pickling Methods 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 101
- 239000002253 acid Substances 0.000 claims description 36
- 238000005406 washing Methods 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 239000006210 lotion Substances 0.000 claims description 10
- 235000021110 pickles Nutrition 0.000 claims description 7
- 238000011010 flushing procedure Methods 0.000 claims description 6
- 239000013040 bath agent Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 2
- 239000008400 supply water Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract description 8
- 238000003860 storage Methods 0.000 abstract description 5
- 238000012544 monitoring process Methods 0.000 abstract description 4
- 101100298222 Caenorhabditis elegans pot-1 gene Proteins 0.000 description 8
- 230000008901 benefit Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000012445 acidic reagent Substances 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 238000011897 real-time detection Methods 0.000 description 2
- 239000006226 wash reagent Substances 0.000 description 2
- 239000002351 wastewater Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- -1 when washing Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
Abstract
The present invention relates to a kind of flow path system and light-induced chemiluminescent analyzer, flow path system includes: dispensing and rinse-system, for dispensing sample and reagent, and rinses for specimen needle and rinses with reagent needle；Sour cleaning system is used for pickling specimen needle and reagent needle；Waste discharge system, for cleaning waste liquid to be discharged.This flow path system realizes the multiple functions such as storage, sample introduction, the waste collection of specimen fluids, high degree of automation, and has real-time monitoring and automatic protection functions, improves the safety and reliability of system.Light-induced chemiluminescent analyzer high degree of automation including the flow path system, safety and reliability are high.
Description
Technical field
The present invention relates to technical field of immunoassay, analyze more particularly, to a kind of flow path system and light-induced chemiluminescent
Instrument.
Background technique
Immunology detection be based on antigen and antibody specific reaction principle carry out, due to its can use isotope,
Enzyme, chemiluminescent substance etc. carry out display or the amplification of signal to measured object, therefore are commonly used for detecting protein, hormone etc. micro-
Measure bioactive substance.
Chemiluminescence immune assay is then to develop relatively rapid on-radiation immunoassay technology in recent years, and principle is benefit
The amplification of signal is carried out with chemiluminescent substance, and by its luminous intensity, immune cohesive process is directly measured, the method
Have become one of the important directions of immunology detection.
But the degree of automation of the flow path system of existing light-induced chemiluminescent analyzer is low, not can be implemented simultaneously specimen fluids
The multiple functions such as storage, sample introduction, waste collection.And stocking system, cleaning system and waste collection system lack centainly real-time
Detection and alarm system, the safety and reliability of system are poor.
Summary of the invention
For the above-mentioned technical problem in the presence of the prior art, the invention proposes a kind of flow path system, the flow path systems
It unites through setting dispensing and rinse-system, sour cleaning system and waste discharge system, realizes storage, the sample introduction, waste liquid receipts of specimen fluids
The multiple functions such as collection, high degree of automation, and have real-time monitoring and automatic protection functions, improve system safety and can
By property.In addition, the light-induced chemiluminescent analyzer not only automates journey the invention proposes a kind of light-induced chemiluminescent analyzer
Degree is high, and safety and reliability is high, can bring the better operating experience of operator.
On the one hand, the present invention provides a kind of flow path systems, comprising: dispensing and rinse-system, for dispensing sample and examination
Agent, and rinse for specimen needle and rinsed with reagent needle；Sour cleaning system is used for pickling specimen needle and reagent needle；Waste discharge system is used
Waste liquid is cleaned in discharge.
As a further refinement of the present invention, the dispensing and rinse-system include: sample allocation unit, for distributing
Sample；Agent dispensing unit, for distributing reagent；Interior rinsing unit, for rinsing the inner wall and the reagent of the specimen needle
The inner wall of needle；Outer rinsing unit, for rinsing the outer wall of the specimen needle and the outer wall of the reagent needle.
As a further refinement of the present invention, the dispensing and rinse-system further include water supplying unit, for being described
Interior rinsing unit and outer rinsing unit provide water for cleaning.
As a further refinement of the present invention, the sample allocation unit includes specimen needle dispensing pump and specimen needle, institute
State the entrance of the outlet connection specimen needle of specimen needle dispensing pump.
As a further refinement of the present invention, the agent dispensing unit includes reagent needle dispensing pump and reagent needle, institute
State the entrance of the outlet connection reagent needle of reagent needle dispensing pump.
As a further refinement of the present invention, the interior rinsing unit includes in specimen needle in flush water pump and reagent needle
Flush water pump, the entrance of flush water pump is all connected with going out for water supplying unit in flush water pump and the reagent needle in the specimen needle
Mouthful, the outlet of flush water pump connects the first solenoid valve in the specimen needle, and first solenoid valve connects the specimen needle dispensing
The entrance of pump, the outlet of flush water pump connects second solenoid valve in the reagent needle, and the second solenoid valve connects the reagent
The entrance of needle dispensing pump.
As a further refinement of the present invention, the outer rinsing unit includes specimen needle outer flush water pump, specimen needle water
Washing trough and reagent needle rinsing bowl, the outlet of the entrance connection water supplying unit of the outer flush water pump of the specimen needle, outside the specimen needle
The outlet of flush water pump connects specimen needle rinsing bowl, the outlet of the specimen needle rinsing bowl and the outlet of the reagent needle rinsing bowl
It is all connected with waste discharge system.
As a further refinement of the present invention, the water supplying unit includes clean water pot, intake pump and inlet valve, it is described
The outlet of the entrance connection intake pump of clean water pot, the entrance of the intake pump connect inlet valve, and the inlet valve connection is catchmented
Pond.
As a further refinement of the present invention, it is equipped with the first liquid level sensor in the cleaning water pot, it is clean for detecting
Clean water in water purification pot.
As a further refinement of the present invention, being equipped with air filter at the air intlet of the cleaning water pot, it is used for
Filtering enters the air of water pot.
As a further refinement of the present invention, the acid cleaning system includes specimen needle descaling bath and reagent needle pickling
The entrance of slot, the specimen needle descaling bath and reagent needle descaling bath is separately connected the outlet of acid wash liquid pump, the acid cleaning
The entrance of liquid pump is separately connected the first check valve, and first check valve is all connected with acid wash liquid bottle, the specimen needle descaling bath
Outlet with reagent needle descaling bath is separately connected waste discharge system.
As a further refinement of the present invention, the second liquid level sensor is equipped in the acid wash liquid bottle, for detecting
Washing lotion amount in acid wash liquid bottle.
As a further refinement of the present invention, the waste discharge system includes negative-pressure cup, the liquid inlet of the negative-pressure cup
It is separately connected the outlet of the specimen needle rinsing bowl, the outlet of specimen needle descaling bath, the outlet of reagent needle rinsing bowl and reagent needle
The outlet of descaling bath, the liquid outlet of the negative-pressure cup connect the entrance of waste discharge liquid pump, the removal waste fluid by third solenoid valve
The entrance of the outlet connection waste liquid bottle of pump, the entrance of the gas vent connection negative pressure pump of the negative-pressure cup.
As a further refinement of the present invention, the gas vent position of the negative-pressure cup is equipped with pressure sensor, it is described
The outside of negative-pressure cup is equipped with the pressure gauge connecting with the pressure sensor.
As a further refinement of the present invention, being equipped with third liquid level sensor in the negative-pressure cup.
As a further refinement of the present invention, the outlet of the negative pressure pump is equipped with muffler.
As a further refinement of the present invention, the first outlet of the specimen needle rinsing bowl and the reagent needle rinsing bowl
First outlet waste liquid branch and reagent needle washed by specimen needle respectively wash the liquid inlet that waste liquid branch connects negative-pressure cup,
The first outlet of the specimen needle descaling bath and the first outlet of the reagent needle descaling bath pass through specimen needle pickle liquor respectively
Branch connects the liquid inlet of negative-pressure cup, the second outlet of the specimen needle rinsing bowl, sample with reagent needle pickle liquor branch
The second outlet of the second outlet of needle descaling bath, the second outlet of reagent needle rinsing bowl and reagent needle descaling bath passes through protection respectively
The entrance of branch connection waste liquid bottle.
On the other hand, the present invention provides a kind of light-induced chemiluminescent analyzer comprising above-mentioned flow path system.
Compared with the prior art, the advantages of the present invention are as follows flow path system according to the present invention passes through setting dispensing and punching
System, sour cleaning system and waste discharge system are washed, the multiple functions such as storage, sample introduction, the waste collection of specimen fluids is realized, automates
Degree is high, and has real-time monitoring and automatic protection functions, improves the safety and reliability of system.Light according to the present invention
Swash chemiluminescent analyzer, due to using above-mentioned flow path system, not only high degree of automation, and safety and can
By property height, the better operating experience of operator can be brought.
Detailed description of the invention
The preferred embodiment of the present invention is described in detail below in conjunction with attached drawing.In figure:
Fig. 1 is the flow path system structural schematic diagram in the embodiment of the present invention.
Fig. 2 is the structure enlargement diagram of the part A10 of the flow path system in the embodiment of the present invention.
Fig. 3 is the rinse bath waste discharge branch structure schematic diagram in the embodiment of the present invention.
In the accompanying drawings, identical component uses identical appended drawing reference.The attached drawing is not drawn according to the actual ratio.
Specific embodiment
Below in conjunction with attached drawing, the present invention will be further described.
As shown in Figure 1, the present invention provides a kind of flow path systems, comprising: dispensing and rinse-system 100, for dispensing sample
This and reagent, and rinsed for specimen needle 24 and reagent needle 27 rinses；Sour cleaning system 200, for pickling specimen needle 24 and examination
Agent needle 27；Waste discharge system 300, for cleaning waste liquid to be discharged.
In one embodiment, the dispensing and rinse-system 100 include: sample allocation unit, for distributing sample；
Agent dispensing unit, for distributing reagent；Interior rinsing unit, for rinsing the inner wall and the reagent needle 27 of the specimen needle 24
Inner wall；Outer rinsing unit, for rinsing the outer wall of the specimen needle 24 and the outer wall of the reagent needle 27.
In one embodiment, the dispensing and rinse-system 100 further include water supplying unit, for being the interior flushing
Unit and outer rinsing unit provide water for cleaning.
In one embodiment, the sample allocation unit includes specimen needle dispensing pump 23 and specimen needle 24, the sample
The entrance of the outlet connection specimen needle 24 of this needle dispensing pump 23.
In one embodiment, the agent dispensing unit includes reagent needle dispensing pump 26 and reagent needle 27, the examination
The entrance of the outlet connection reagent needle 27 of agent needle dispensing pump 26.
It should be understood that the agent dispensing unit can be one or more, present embodiment discloses three reagents point
With unit, as shown in Fig. 2, two of them agent dispensing unit A and B (region as shown in wire in Fig. 2) are used to distribution reagent,
Another agent dispensing unit C (region as shown in wire in Fig. 2) is for distributing general liquid.
In one embodiment, the interior rinsing unit includes flushing water in flush water pump 25 and reagent needle in specimen needle
Pump 29, the entrance of flush water pump 29 is all connected with going out for water supplying unit in flush water pump 25 and the reagent needle in the specimen needle
Mouthful, the outlet of flush water pump 25 connects the first solenoid valve 22 in the specimen needle, and first solenoid valve 22 connects the sample
Needle dispensing pumps 23 entrance, and the outlet of flush water pump 29 connects second solenoid valve 28, the second solenoid valve in the reagent needle
The entrance of the 28 connections reagent needle dispensing pump 26.
In one embodiment, the outer rinsing unit include the outer flush water pump 21 of specimen needle, specimen needle rinsing bowl and
Reagent needle rinsing bowl, the outlet of the entrance connection water supplying unit of the outer flush water pump 21 of the specimen needle, the specimen needle are rinsed outside
The outlet of water pump 21 connects specimen needle rinsing bowl, and the outlet of the specimen needle rinsing bowl and the outlet of the reagent needle rinsing bowl are equal
Connect waste discharge system 300.
In one embodiment, the sour cleaning system 200 includes specimen needle descaling bath 6 and reagent needle descaling bath 6, institute
The entrance for stating specimen needle descaling bath 6 and reagent needle descaling bath 5 is separately connected the outlet that acid wash liquid pumps 7, the acidic cleaning solution
The entrance of pump 7 is separately connected the first check valve 8, and first check valve 8 is all connected with acid wash liquid bottle 9, the specimen needle pickling
The outlet of slot 6 and reagent needle descaling bath 5 is separately connected waste discharge system 300.
Preferably, the specimen needle rinsing bowl and the specimen needle descaling bath 6 share (following to be denoted as specimen needle rinse bath),
The reagent needle rinsing bowl and reagent needle descaling bath 5 share (following to be denoted as reagent needle rinse bath).Specimen needle rinse bath and reagent
Needle rinse bath is separately connected waste discharge system.
When washing, high pressure water is flowed out by specimen needle dispensing pump 23 from 24 inner cavity of specimen needle, rinses 24 inner wall of specimen needle, from
The water that specimen needle 4 flows out, by specimen needle rinse bath 6, and has cleaned the outer wall of specimen needle 24.It is high when being rinsed in reagent needle 27
Water is pressed to flow out by reagent needle dispensing pump 26 from 27 inner cavity of reagent needle, 27 inner wall of wash reagent needle；The water flowed out from reagent needle 27,
By reagent needle rinse bath 5, and the outer wall of reagent needle 27 is cleaned.But since 24 internal diameter of specimen needle is smaller, in the unit time
The water flow flowed out from its inner cavity is not enough to clean up specimen needle 24, so increasing the outer flush water pump 21 of specimen needle, increases sample
Water flow in this needle rinsing bowl 6 cleans up specimen needle 24.And 27 internal diameter of reagent needle is bigger, only by interior flushing,
Water flow in unit time is cleaned up enough.
When pickling, washing lotion is flowed into specimen needle rinse bath 6 by acid wash liquid pump 7, and specimen needle 24 is cleaned in specimen needle
Compressing 10 times repeatedly in slot 6, to achieve the purpose that acid specimen needle 24；When reagent needle acidity, washing lotion passes through acid wash liquid pump 7
It is flowed into reagent needle rinse bath 5, reagent needle compressing 10 times repeatedly in reagent needle rinse bath 5, to reach acid reagent needle
27 purpose.
It is equipped with the second liquid level sensor 10 in the acid wash liquid bottle 9, for detecting the washing lotion amount in acid wash liquid bottle 9.
In one embodiment, the water supplying unit includes clean water pot 1, intake pump 3 and inlet valve 4, the cleaning
The outlet of the entrance connection intake pump 3 of water pot 1, the entrance of the intake pump 3 connect inlet valve 4, and the connection of inlet valve 4 is catchmented
Pond (not shown).
In one embodiment, it is equipped with the first liquid level sensor 2 in the clean water pot 1, for detecting clean water pot 1
Interior clean water.
In one embodiment, be equipped with air filter 30 at the air intlet of the clean water pot 1, for filter into
Enter the air of water pot.
In one embodiment, the waste discharge system 300 includes negative-pressure cup 14, and the liquid inlet of the negative-pressure cup 14 connects
The sour cleaning system 200 is connect, the liquid outlet of the negative-pressure cup 14 connects entering for waste discharge liquid pump 17 by third solenoid valve 16
Mouthful, the entrance of the outlet connection waste liquid bottle 33 of the waste discharge liquid pump 17, the gas vent of the negative-pressure cup 14 connects negative pressure pump 13
Entrance, and between the gas vent of the negative-pressure cup 14 and the entrance of affiliated negative pressure pump 13 be equipped with second one-way valve 20.Fig. 1 institute
Show in embodiment, the outlet of the waste discharge liquid pump 17 is incorporated to the 4th branch A0, and the 4th branch A0 is incorporated to waste discharge liquid pump 17
The rear end of position is equipped with third check valve 34, and when the flow of waste discharge liquid pump 17 is excessive, the third check valve 34 can be prevented
Waste liquid is flow backwards.
In one embodiment, the gas vent position of the negative-pressure cup 14 is equipped with pressure sensor 12, the negative pressure
The outside of tank 14 is equipped with the pressure gauge 19 connecting with the pressure sensor 12.
In one embodiment, third liquid level sensor 15 is equipped in the negative-pressure cup 14.
In one embodiment, the outlet of the negative pressure pump 13 is equipped with muffler 11.
In one embodiment, the first of the first outlet of the specimen needle rinsing bowl and the reagent needle rinsing bowl goes out
Mouth washes waste liquid branch by specimen needle respectively and washes the liquid inlet that waste liquid branch connects negative-pressure cup, the sample with reagent needle
The first outlet of needle descaling bath and the first outlet of the reagent needle descaling bath pass through specimen needle pickle liquor branch and examination respectively
Agent needle pickle liquor branch connects the liquid inlet of negative-pressure cup, the second outlet of the specimen needle rinsing bowl, specimen needle descaling bath
Second outlet, the second outlet of reagent needle rinsing bowl with the second outlet of reagent needle descaling bath respectively pass through protection branch connect
The entrance of waste liquid bottle.
In above-mentioned preferred embodiment, since the specimen needle rinsing bowl and the specimen needle descaling bath 6 are shared (following
It is denoted as specimen needle rinse bath), the reagent needle rinsing bowl and reagent needle descaling bath 5 share (following to be denoted as reagent needle rinse bath).
Specifically, as shown in figures 1 and 3, the outlet a of the specimen needle rinse bath 6 and a of the reagent needle rinse bath 5 export difference
Waste liquid first branch A1 is cleaned by specimen needle and reagent needle cleans waste liquid first branch A1 ' connection negative-pressure cup 14, the sample
Needle rinse bath 6 b outlet and the reagent needle rinse bath 5 b outlet respectively by specimen needle clean waste liquid second branch A2 with
Reagent needle cleans waste liquid second branch A2 ' connection negative-pressure cup 14, the outlet c of the specimen needle rinse bath 6 and reagent needle rinse bath 5
C outlet respectively by specimen needle clean waste liquid third branch A3 and reagent needle cleaning waste liquid third branch A3 ' connection waste liquid bottle
33。
Wherein, specimen needle cleaning waste liquid first branch A1 and reagent needle cleaning waste liquid first branch A1 ' is washed useless for draining
Liquid, when washing, water is ceaselessly flowed in specimen needle rinse bath 6 and reagent needle rinse bath 5, and sample needle 24 and reagent needle 27 pass through anti-
It relapses to spit and achievees the purpose that washing.Waste liquid after washing cleans waste liquid first branch A1 by specimen needle and reagent needle cleans waste liquid
First branch A1 ' flow to negative-pressure cup, and water is discharged in time.Circulating water is formed in this way, is reached and is rinsed specimen needle 24 and reagent needle 27
Purpose.
Specimen needle cleaning waste liquid second branch A2 and reagent needle cleaning waste liquid second branch A2 ' are for arranging pickle liquor, acid
When washing, acid wash liquid is flowed in specimen needle rinse bath 6 and reagent needle rinse bath 5, and sample needle 24 and reagent needle 27 by inhaling repeatedly
It spits and achievees the purpose that pickling.Acid wash liquid after pickling cleans waste liquid second branch A2 by specimen needle and reagent needle cleans waste liquid
Second branch A2 ' flow to negative-pressure cup, and acid wash liquid is discharged in time, achievees the purpose that flushing needle.
It is to protect branch that specimen needle, which cleans waste liquid third branch A3 and reagent needle cleaning waste liquid third branch A3 ',.Sample
Needle cleaning waste liquid third branch A3 and reagent needle cleaning waste liquid third branch A3 ' are directly connected to waste liquid bottle 33.When water wash system, acid
It washes system and when waste discharge system breaks down, can prevent water or acid wash liquid from overflowing, water and acid wash liquid are logical by dead weight
Specimen needle cleaning waste liquid third branch A3 and the cleaning waste liquid third branch A3 ' discharge of reagent needle are crossed, to prevent water or acidity from washing
Hydrorrhea, which goes out, causes instrument damage.
It in the above-described embodiments, accordingly include reagent disc 31 and general liquid disk 32.Due to reagent disc 31 and general liquid disk
32 standing temperature are 2-8 DEG C, and the steam in disk in air will form cold water drenching, therefore the reagent disc 31 and general liquid disk 32 are arranged
It is cleaned on waste liquid third branch A3 or reagent needle cleaning waste liquid third branch A3 ' in specimen needle, the cold water drenching formed in disk passes through
Specimen needle cleaning waste liquid third branch A3 or reagent needle cleaning waste liquid third branch A3 ' finally flow into waste liquid bottle 33.
In Fig. 1 and embodiment illustrated in fig. 3, specimen needle cleaning waste liquid third branch A3 and reagent needle cleaning waste liquid the
Three branch A3 ' are incorporated in the 4th branch A0 in rear end, the reagent disc 31 and the general liquid disk 32 setting after merging the
On four branch A0.
A kind of workflow of this system is explained in detail below:
1, sample and reagent are dispensed
When sample dispenses, the first solenoid valve 22 is closed, and specimen needle dispensing pump 23 is driven by motor, and is drawn by specimen needle 24
Sample and dispensing sample；
When reagent dispenses, second solenoid valve 28 is closed, and reagent needle dispensing pump 26 is driven by motor, and is drawn by reagent needle 27
Reagent and dispensing reagent；It should be understood that dispensing general liquid if necessary, then one of agent dispensing unit is logical for distributing
With liquid, likewise, second solenoid valve 28 is closed, general liquid needle dispensing pump is driven by motor, and draws general liquid by general liquid needle
With the general liquid of dispensing.
2, specimen needle is rinsed and reagent needle rinses
When water level reaches the first water level in clean water pot 1, inlet valve 4 is opened, and intake pump 3 is started into water；Clean water pot 1
When middle water level rises to the second water level, intake pump 3 is closed, and stops water inlet, and inlet valve 4 is closed.Water level rises in clean water pot 1
When third water level, water-level alarm needs artificially to check.When rinsing in specimen needle, the first solenoid valve 22 is opened, and is rinsed in specimen needle
Water pump 25 starts, and high pressure water is flowed out by specimen needle dispensing pump 23 from 24 inner cavity of specimen needle, 24 inner wall of specimen needle is rinsed, from sample
The water that needle 4 flows out, by specimen needle rinse bath 6, and has cleaned the outer wall of specimen needle 24.When being rinsed in reagent needle 27, the second electricity
Magnet valve 28 is opened, and flush water pump 29 starts in reagent needle, and high pressure water is flowed out by reagent needle dispensing pump 26 from 27 inner cavity of reagent needle.
27 inner wall of wash reagent needle；The water flowed out from reagent needle 27, by reagent needle rinse bath 5, and has cleaned the outer wall of reagent needle 27.
When rinsing outside specimen needle 24, the outer flush water pump 21 of specimen needle starts, and high pressure water flow is to specimen needle rinse bath 6, in sample
Specimen needle 24 is by compressing repeatedly in this needle rinse bath 6, so that the inner and outer wall of specimen needle 24 be cleaned up.
3, specimen needle pickling and reagent needle pickling
When acid wash liquid liquid level is lower than the liquid level of the second liquid level sensor 10 in acid wash liquid bottle, the second liquid level sensor
10 will call the police, and prompting needs to add acid wash liquid；After adding washing lotion, liquid level warning can be cancelled automatically.Specimen needle 24 carries out pickling
When, corresponding acid wash liquid pump 7 starts.Washing lotion is flowed into specimen needle rinse bath 6 by acid wash liquid pump 7, and specimen needle 24 exists
Compressing 10 times repeatedly in specimen needle rinse bath 6, to achieve the purpose that acid specimen needle 24；When reagent needle acidity, corresponding acid
Property lotion pumps 7 are started.Washing lotion is flowed into reagent needle rinse bath 5 by acid wash liquid pump 7, and reagent needle is in reagent needle rinse bath 5
In compressing 10 times repeatedly, to achieve the purpose that acid reagent needle 27.
4, removal waste fluid
When the air pressure in negative-pressure cup 14 is higher than -1.5kg/m2When, negative pressure pump 13 starts.Air is through 11 noise reduction of muffler
Outflow, when the air pressure in negative-pressure cup 14 is lower than -2.5kg/m2When, negative pressure pump 13 is closed.When waste liquid liquid level is higher than third liquid
When 15 alarm liquid level of level sensor, waste discharge liquid pump 17 starts, and third solenoid valve 16 is opened, and starts removal waste fluid.When waste liquid is lower than report
When alert liquid level, third solenoid valve 16 is closed, and waste discharge liquid pump 17 stops.Reagent needle rinse bath 5 and specimen needle rinse bath 6 are after washing
0.2S opens third solenoid valve 16, starts to clear and washes waste water, and third solenoid valve 16 is closed after cleaning.Reagent needle rinse bath 5
0.2S opens third solenoid valve 16 after the completion of pickling with specimen needle rinse bath 6, starts to clear and washes pickling washing lotion waste water, has cleaned
Third solenoid valve 16 is closed after finishing.
This flow path system the degree of automation is relatively high.Not only allow for stocking system, it is also contemplated that waste collection system, shape
At closed-loop control.And due to the external pressure sensor of negative-pressure cup, it can prompt whether negative pressure pot liquid is able to satisfy experiment institute
The number of injections needed.If negative pressure pot liquid is used up, this system can prompt operator to carry out changing bottle movement.Clean water
Tank, acid wash liquid bottle and waste liquid bottle are equipped with liquid level sensor, once cleaning solution is used up or waste liquid bottle is full of, this system can be in time
It provides corresponding prompt and quiescing personnel carries out any operation, have and only operator adds cleaning solution again or falls
After falling the waste liquid in waste liquid bottle, this system can just operate again.
There is higher the degree of automation using the light-induced chemiluminescent analyzer of above-mentioned flow path system, simultaneously because increasing
Added real-time detection and automatic protection functions so that light-induced chemiluminescent analyzer is more intelligent, the safety of analyzer and
Reliability is higher, can bring the better operating experience of operator.
Compared with the prior art, the advantages of the present invention are as follows flow path system according to the present invention passes through setting dispensing and punching
System, sour cleaning system and waste discharge system are washed, the multiple functions such as storage, sample introduction, the waste collection of specimen fluids is realized, automates
Degree is high, and has real-time monitoring and automatic protection functions, improves the safety and reliability of system.Light according to the present invention
Swash chemiluminescent analyzer, due to using above-mentioned flow path system, not only high degree of automation, and safety and can
By property height, the better operating experience of operator can be brought.
The foregoing is merely the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, Ren Heben
The technical staff in field can be easy to carry out and be altered or varied in technical scope disclosed by the invention, and this change or change
Change should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of claims
Subject to enclosing.
Claims (18)
1. a kind of flow path system characterized by comprising
Dispensing and rinse-system for dispensing sample and reagent, and are rinsed for specimen needle and are rinsed with reagent needle；
Sour cleaning system is used for pickling specimen needle and reagent needle；
Waste discharge system, for cleaning waste liquid to be discharged.
2. flow path system according to claim 1, which is characterized in that the dispensing and rinse-system include:
Sample allocation unit, for distributing sample；
Agent dispensing unit, for distributing reagent；
Interior rinsing unit, for rinsing the inner wall of the specimen needle and the inner wall of the reagent needle；
Outer rinsing unit, for rinsing the outer wall of the specimen needle and the outer wall of the reagent needle.
3. flow path system according to claim 2, which is characterized in that the dispensing and rinse-system further include supply water it is single
Member, for providing water for cleaning for the interior rinsing unit and the outer rinsing unit.
4. flow path system according to claim 3, which is characterized in that the sample allocation unit includes specimen needle dispensing pump
And specimen needle, the outlet of the specimen needle dispensing pump connect the entrance of the specimen needle.
5. flow path system according to claim 4, which is characterized in that the agent dispensing unit includes reagent needle dispensing pump
Outlet with reagent needle, the reagent needle dispensing pump connects the entrance of the reagent needle.
6. flow path system according to claim 5, which is characterized in that the interior rinsing unit includes flushing water in specimen needle
Flush water pump in pump and reagent needle, the entrance of flush water pump is all connected with institute in flush water pump and the reagent needle in the specimen needle
The outlet of water supplying unit is stated, the outlet of flush water pump connects the first solenoid valve, the first solenoid valve connection in the specimen needle
The specimen needle dispenses the entrance of pump, and the outlet of flush water pump connects second solenoid valve, second electromagnetism in the reagent needle
Valve connects the entrance of the reagent needle dispensing pump.
7. flow path system according to claim 3, which is characterized in that the outer rinsing unit includes the outer flushing water of specimen needle
The entrance of pump, specimen needle rinsing bowl and reagent needle rinsing bowl, the outer flush water pump of the specimen needle connects going out for the water supplying unit
Mouthful, the outlet of the outer flush water pump of the specimen needle connects the specimen needle rinsing bowl, the outlet of the specimen needle rinsing bowl and institute
The outlet for stating reagent needle rinsing bowl is all connected with waste discharge system.
8. the flow path system according to any one of claim 3-7, which is characterized in that the water supplying unit includes clean water
Tank, intake pump and inlet valve, the entrance of the cleaning water pot connect the outlet of the intake pump, the entrance connection of the intake pump
The inlet valve, the inlet valve connect collecting-tank.
9. flow path system according to claim 8, which is characterized in that be equipped with the first level sensing in the cleaning water pot
Device, for detecting the clean water in clean water pot.
10. flow path system according to claim 8, which is characterized in that be equipped with sky at the air intlet of the cleaning water pot
Air filter, for filtering the air for entering water pot.
11. flow path system according to claim 7, which is characterized in that the acid cleaning system includes specimen needle descaling bath
With reagent needle descaling bath, the entrance of the specimen needle descaling bath and reagent needle descaling bath is separately connected the outlet of acid wash liquid pump,
The entrance of the acid wash liquid pump is separately connected the first check valve, and first check valve is all connected with acid wash liquid bottle, the sample
The outlet of this needle descaling bath and reagent needle descaling bath is separately connected waste discharge system.
12. flow path system according to claim 11, which is characterized in that be equipped with the second liquid level in the acid wash liquid bottle and pass
Sensor, for detecting the washing lotion amount in acid wash liquid bottle.
13. the described in any item flow path systems of 1-12 according to claim 1, which is characterized in that the waste discharge system includes negative pressure
Tank, the liquid inlet of the negative-pressure cup are separately connected the outlet of the specimen needle rinsing bowl, the outlet of specimen needle descaling bath, reagent
The liquid outlet of the outlet of needle rinsing bowl and the outlet of reagent needle descaling bath, the negative-pressure cup connects waste discharge by third solenoid valve
The entrance of liquid pump, the entrance of the outlet connection waste liquid bottle of the waste discharge liquid pump, the gas vent of the negative-pressure cup connect negative pressure pump
Entrance.
14. flow path system according to claim 13, which is characterized in that the gas vent position of the negative-pressure cup is equipped with pressure
Force snesor, the outside of the negative-pressure cup are equipped with the pressure gauge connecting with the pressure sensor.
15. flow path system according to claim 13, which is characterized in that be equipped with third level sensing in the negative-pressure cup
Device.
16. flow path system according to claim 13, which is characterized in that the outlet of the negative pressure pump is equipped with muffler.
17. flow path system described in any one of 4-16 according to claim 1, which is characterized in that the specimen needle rinsing bowl
First outlet and the first outlet of the reagent needle rinsing bowl are washed by specimen needle washing waste liquid branch and reagent needle useless respectively
The liquid inlet of liquid branch connection negative-pressure cup, the first of the first outlet of the specimen needle descaling bath and the reagent needle descaling bath
Outlet connects the liquid inlet of negative-pressure cup, the sample by specimen needle pickle liquor branch with reagent needle pickle liquor branch respectively
The second outlet of this needle rinsing bowl, the second outlet of specimen needle descaling bath, the second outlet of reagent needle rinsing bowl and reagent needle acid
The second outlet of washing trough passes through the entrance of protection branch connection waste liquid bottle respectively.
18. a kind of light-induced chemiluminescent analyzer, which is characterized in that including according to claim 1 to described in any one of 17
Flow path system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810142680.9A CN110146492A (en) | 2018-02-11 | 2018-02-11 | Flow path system and light-induced chemiluminescent analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810142680.9A CN110146492A (en) | 2018-02-11 | 2018-02-11 | Flow path system and light-induced chemiluminescent analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110146492A true CN110146492A (en) | 2019-08-20 |
Family
ID=67588952
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810142680.9A Pending CN110146492A (en) | 2018-02-11 | 2018-02-11 | Flow path system and light-induced chemiluminescent analyzer |
Country Status (1)
| Country | Link |
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| CN (1) | CN110146492A (en) |
Cited By (1)
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| WO2023098393A1 (en) * | 2021-12-03 | 2023-06-08 | 中翰盛泰生物技术股份有限公司 | Liquid path system for immunodetection |
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Address after: 201210 floor 3 and 5, building 1, No. 88, Cailun Road, free trade zone, Pudong New Area, Shanghai Applicant after: BEYOND DIAGNOSTICS (SHANGHAI) Co.,Ltd. Applicant after: Kemei Diagnostic Technology Co., Ltd Address before: 201210 Pudong New Area, Shanghai, Zhangjiang Cai Lun Road, building 2, 3 floor, east 2. Applicant before: BEYOND DIAGNOSTICS (SHANGHAI) Co.,Ltd. Applicant before: BEIJING CHEMCLIN BIOTECH Co.,Ltd. |
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Address after: 200131 3rd and 5th floors, building 1, No.88 Cailun Road, Pudong New Area pilot Free Trade Zone, Shanghai Applicant after: Kemei Boyang diagnostic technology (Shanghai) Co.,Ltd. Applicant after: Kemei Diagnostic Technology Co., Ltd Address before: 201210 the third and fifth floors of Building 1, No. 88, Cailun Road, Pudong New Area, Shanghai Applicant before: BEYOND DIAGNOSTICS (SHANGHAI) Co.,Ltd. Applicant before: Kemei Diagnostic Technology Co., Ltd |