JPH05293448A - Automatic chemical analyser - Google Patents

Abstract

PURPOSE:To minimize damage to at the time of the exhaustion of pure water, to enhance measuring efficiency as a whole, to exclude the lowering of measur ing accuracy caused by the interference between items and to reduce the load of an operator. CONSTITUTION:Samples are distributed to the reaction cells 30...30 of a reaction disc 31 under the control of a controller 4 and a reagent is distributed to the reaction cells 30 from a reagent stocker 20 and the cells 30 are passed through a photometric part 33 to operate the concns. of the samples. The cells 30 after the completion of photometry are washed with pure water in a washing unit 100 and distribution probes 13a, 22a are also washed with pure water. The level of pure water in a pure water tank is detected by a float switch 120. When the exhaustion of pure water is judged, the controller 4 stops washing treatment using pure water and continues only the concn. operation of normal distribution to return the position of the reaction disk 31 to the position at the time of the exhaustion of pure water. At the time of the exhaustion of pure water, a pure water exhaustion mark is applied to the data of the respective cells at the reagent distribution position from the sample distribution position.

Description

Detailed Description of the Invention

[0001]

This invention relates to a liquid sample such as blood or urine which is reacted with a reagent and then the absorbance is automatically measured.
The present invention relates to an automatic chemical analysis device that calculates and displays a concentration based on the absorbance, and particularly to an improvement measure for a device in which pure water is used for cleaning and the like when the pure water runs out.

[0002]

2. Description of the Related Art An automatic chemical analyzer is disclosed in, for example, Japanese Patent Publication 1-
As can be seen in the apparatus described in No. 47744, it is possible to perform multi-item analysis on a sample such as serum by using an analysis method such as a colorimetric method or a reaction rate method, which is widely used in medical institutions. .. In this type of automatic chemical analyzer,
Since it is necessary to wash the sampling probe for sample dispensing, the reagent probe for reagent dispensing, and the reaction cell of the reaction disk, it is equipped with a pure water tank and a detergent bottle. In addition, pure water and detergent can be supplied to required places at a predetermined timing.

Therefore, it is necessary to avoid the situation where the supply of pure water is stopped as much as possible, and it is necessary to take measures against running out of pure water. As measures against this, for example, JP-A-62-21
Liquid level detection device using impedance change described in No. 8818, float switch having mechanical contact points, and magnetic sensor using magnet for floating body to detect the water level of pure water, and the pure water disappears or is regulated. When it falls to a level, an alarm is issued to the operator to prompt the necessary treatment.

[0004]

However, since an operator who operates this kind of automatic chemical analysis device is often in charge of operating a plurality of devices by himself, he may not notice the alarm of deionized water. However, if the alarm is not noticed or the treatment is delayed, various problems as described below will occur.

First, when the alarm is delayed to notice and the pure water runs out, even if the pure water level is restored by drawing air into the washing syringe, sampling syringe and reagent syringe in the apparatus, After that, it takes time until the air in the flow path is exhausted, and as a result, the flow path must be idled until it is filled with pure water, which leads to re-measurement and stagnation, and measurement efficiency increases. There was a problem of a significant drop.

In addition, when a large amount of air enters the syringe as described above, the air acts as a buffer, and the pressure change due to the vertical direction of the plunger accurately causes the flow path of the sampling probe and the reagent probe. Without being transmitted, there is a risk that the quantitative accuracy of the sample or the reagent will decrease and the reliability of the measurement accuracy will also decrease. Therefore, it is necessary to follow up from the measurement results at what point pure water was running out, and take measures such as re-measurement if necessary. Will put an excessive burden on.

Further, when the pure water runs out during the cleaning of the reaction cell, the reaction cell is not sufficiently cleaned, so that the reagent of the previously measured item remains in the reaction cell, which adversely affects the item to be measured this time. So-called "inter-item interference"
(Or also referred to as “reagent interference”). Furthermore, if the reaction cell is not thoroughly washed, the dry rod attached to the washing unit will be contaminated with residual reagents.
Secondary pollution spreads. In such a situation, it takes a considerable amount of time to investigate the cause, such as reagent interference, even after the pure water level is restored and sufficient cleaning is performed, and during that time, the measurement accuracy decreases, etc. It causes unnecessary troubles such as a decrease in power consumption, and it takes a considerable amount of time and effort to return to the normal state.

The present invention has been made in view of the above-mentioned various problems, and it is possible to detect the running-out of pure water and to make the operating state after the detection progress to a situation in which the measurement accuracy and the measurement efficiency decrease. The first purpose is to prevent in advance. In addition to the first purpose, a second purpose is to prevent reagent contamination of the drying rod of the cleaning unit and to prevent secondary interference between items. A third object is to simplify the operation management of the device and reduce the burden on the operator. A fourth object is to reduce the operating cost without wastefully using the cell detergent.

[0009]

In order to achieve the above object, in the automatic chemical analyzer according to the invention of claim 1,
A reaction part that holds a cell row composed of multiple reaction cells, and this reaction part moves from the preset sample dispensing position to the reagent dispensing position or from the reagent dispensing position to the sample dispensing position toward the washing position. A reaction part moving means, a sample dispensing means for dispensing a sample to the reaction cell located at the sample dispensing position, and a reagent dispensing means for dispensing a reagent to the reaction cell located at the reagent dispensing position. A washing means for washing the reaction cell located at the washing position with at least pure water, and a tank connected to an external pure water producing apparatus and storing the pure water supplied from the pure water producing apparatus And a photometric unit that is arranged across the cell row and optically measures the concentration change of the sample in the reaction cell, and a reaction cell that has finished collecting photometric data based on the photometric data of this photometric unit. Calculate concentration Degree calculating means, pure water amount detecting means for detecting the pure water amount in the tank, and pure water running-out judging means for judging whether or not the pure water running out in the tank has occurred based on the detection signal of the pure water quantity detecting means. When the pure water running-out determination means determines that the pure water is running out, a stop command means for stopping the cleaning by the cleaning means and stopping the dispensing of the sample dispensing means and the reagent dispensing means, and the pure water running out The position storing means stores the moving position of the reaction part when the judging means judges that the pure water has run out, and the position of the reaction part is stored in the position storing means after the calculation of the concentration calculating means is completed. Position return command means for giving a command to the reaction part moving means to return to the position and stop.

In the automatic chemical analyzer according to the second aspect of the present invention, a reaction section holding a cell array composed of a plurality of reaction cells, and a reaction section from a preset sample dispensing position to a reagent dispensing position Alternatively, a reaction part moving means for moving from the reagent dispensing position to the washing position through the sample dispensing position, a sample dispensing means for dispensing a sample into the reaction cell located at the sample dispensing position, and the reagent A reagent dispensing means for dispensing a reagent to the reaction cell located at the dispensing position, a cleaning means for cleaning the reaction cell located at the cleaning position with at least pure water, and an external pure water production apparatus are connected. And a tank for storing the pure water supplied from the pure water producing apparatus, a photometric unit arranged across the cell row and optically measuring the concentration change of the sample in the reaction cell, In the photometric data of this photometry unit Then, the concentration calculating means for calculating the concentration of the reaction cell whose photometric data has been collected, the pure water amount detecting means for detecting the pure water amount in the tank, and the pure water in the tank based on the detection signal of the pure water amount detecting means. Deionized water depletion determining means for determining whether or not a depletion has occurred, and when the deionized water depletion determination means determines deionized water depletion, the washing by the washing means is stopped and the sample dispensing means and reagent dispensing Stop command means for stopping the dispensing of the means and a reaction cell in which when the stop command means issues a stop command, the reagent dispensing means cannot dispense the final reagent or the sample dispensing means cannot dispense the sample And a means for giving a mark indicating depletion of pure water is added to the stored information for.

Particularly, in the automatic chemical analyzer according to the third aspect of the present invention, each of the sample dispensing means and the reagent dispensing means has a syringe into which pure water is introduced from the tank, and the volume of the syringe. It is a means for dispensing by the pressure accompanying the change.

According to the fourth aspect of the present invention, in the automatic chemical analyzer, the amount of pure water in the tank is changed while the concentration calculation unit is performing the concentration calculation after the stop command unit issues the stop command. A pure water amount re-detection means for re-detection, a pure water amount elimination judging means for judging whether or not the pure water amount in the tank is eliminated based on the detection signal of the pure water amount re-detection means, and this pure water amount And a restart command means for canceling the operation suspension of the sample dispensing means, the reagent dispensing means, and the cleaning means and restarting the measurement when the solution determining means determines that the depletion of pure water is resolved.

In the automatic chemical analyzer according to the fifth aspect of the present invention, at the start of measurement, a pure water run-out determination means at the start of measurement for judging whether or not the pure water run-out detection means has detected pure water run-out, When the deionized water depletion judging means at the start of the measurement judges deionized water depletion, there is provided a priming water commanding means for causing the deionized water producing device to draw deionized water into the deionized water tank.

In the automatic chemical analyzer according to the sixth aspect of the present invention, the priming water commanding means is provided with a mechanism for performing an extra priming operation for the volume of the flow path from the tank to the cleaning means.

According to a seventh aspect of the present invention, in the automatic chemical analyzer, the cleaning means is means for cleaning with the pure water and the detergent, the detergent supplying means for supplying the detergent, and the pure water running out. When the detection means detects the depletion of pure water,
The automatic chemical analyzer according to claim 1 or 2, further comprising: a detergent supply stopping means for stopping the detergent supply by the detergent supplying means.

In the automatic chemical analyzer according to the eighth aspect of the present invention, the concentration calculation means is a means including a mechanism for stopping the concentration calculation for the photometric data of the reaction cell marked by the deionized water mark providing means. is there.

[0017]

In the automatic chemical analyzer according to the first and third aspects of the present invention, the amount of pure water in the tank is detected by the pure water amount detecting means, and based on the pure water amount detection signal, it is determined whether or not the tank is out of pure water. It is also judged by the pure water running-out judging means. When it is determined that the pure water has run out, the stop command means stops the cell cleaning by the cleaning means and the dispensing of the sample dispensing means and the reagent dispensing means. The moving position of the reaction part when the deionized water is determined is stored in the position storing means, and after the calculation of the concentration calculating means is completed, the position of the reaction portion is returned to the storage position of the position storing means and stopped. The reaction unit moving means is instructed by the position return instruction means. Therefore, when the pure water runs out, the dispensing operation of the sample and reagent and the cell cleaning are automatically stopped. Therefore, the waste of the sample and the reagent is eliminated, and the preparation for the measurement stop is performed. Eliminate interference between items due to water shortage. Further, when the concentration calculation is completed, the reaction part is automatically returned to the position where the deionized water has run out, and the process is completed.

In the automatic chemical analyzer according to the second and third aspects of the present invention, especially in the case of running out of pure water, the pure water running out mark giving means is provided for the reaction cell in which the final reagent cannot be dispensed or the sample cannot be dispensed. Is marked by. This makes it possible to easily determine which reaction cell did not perform normal measurement.

In the automatic chemical analyzer according to the fourth aspect of the present invention, the amount of pure water in the tank is re-detected by the pure water amount re-detecting means while the concentration calculation is performed after the pure water runs out. Based on this detection signal, the deionized water elimination determination means determines whether or not the deionized water in the tank has been eliminated. When it is determined that the depletion of pure water is resolved, the restart command means restarts sample dispensing and reagent dispensing, and restarts cleaning. Therefore, the labor of operating the device is saved.

In the automatic chemical analyzer according to the fifth and sixth aspects of the present invention, the determination means determines whether or not the deionized water detection means has detected deionized water at the start of measurement. When the pure water is exhausted, the pure water commanding means causes pure water to be drawn into the pure water tank from the external pure water producing device.

In the automatic chemical analyzer according to the seventh aspect of the present invention, when the pure water runs out, the detergent supply from the detergent supply means to the cleaning means is stopped.

In the automatic chemical analyzer according to the eighth aspect of the present invention, the calculation of the concentration is performed only for the reaction cell in the normal state where there is no deionized water, and the calculation load is reduced.

[0023]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of the present invention will be described below with reference to FIGS.

1 to 4 show the entire structure of the automatic chemical analyzer according to this embodiment. Of these, FIG. 1 shows the external appearance of the device and the electrical connection state, and FIGS. 3 and 4 show the flow channel connection state. 3 and 4 jointly show one flow path system.

First, the automatic chemical analyzer shown in FIGS. 1 to 4 has a sampling system mechanism 1 for holding and dispensing samples, and a reagent system mechanism 2 for retaining and dispensing reagents.
A reaction system mechanism 3 for detecting the concentration of the sample by reacting the sample and the reagent, and a controller 4 for controlling the entire apparatus
And an input / output mechanism 5 for inputting / outputting operator commands and data, and a cleaning system mechanism 6 (the main parts thereof are shown in FIGS. 3 and 4).
It has and.

The mechanism 1 of the sampling system comprises a plurality of sample cups 10 ... 10 for filling a sample and a disk-shaped sampler (which holds the sample cups 10 ... 10 in a circular arrangement when viewed from the apparatus ( 11), and this sampler 11 as the controller 4
A sampler drive unit 12 that rotates based on a control signal CS1 from the sampler, a sampling arm 13 that dispenses a sample in the sample cups 10 ... 10, and a vertical movement of the sampling arm 13 based on a control signal CS2 of the controller 4. And a rotatable sampling arm drive unit 14. The sampling arm 13 has a needle-shaped sampling probe 13a hung at its tip, and a channel is connected to the sampling probe 13a as shown in FIG.

Therefore, the sampler 11 has the controller 4
Sample cup 1 because it can be rotated by the command
It is possible to place 0 ... 10 at the sample suction position by controlling the rotation angle of the sampler 11. The sampling probe 13a is rotatable in response to a command to the sampling arm drive unit 14 of the controller 4 so as to draw an arcuate orbit of a predetermined diameter between the sampler 11 and a reaction disc in the reaction system mechanism 3 described later. , It is possible to move up and down in the arc orbit.

The reagent system mechanism 2 has a circular arc shape when viewed from above the apparatus and is adjacent to the sampler 11 in the reagent storage 20.
And a plurality of reagent bottles 21 loaded in this reagent piece 20
21 and this reagent bottle 21 ... Aspirate the reagent in 21
Reagent dispensing arm 22 for dispensing and this reagent dispensing arm 2
2 is provided with a reagent dispensing arm drive unit 23 that can be rotated and moved up and down by a control signal CS3 of the controller 4. The reagent dispensing arm 22 includes a needle-shaped reagent probe 22a.
Is hung on its tip, and this reagent probe 22a
As shown in FIG. 2, a flow path is connected to the.

For this reason, the reagent probe 22a has an arcuate orbit of a predetermined diameter between the reagent storage 20 and a reaction disk in the reaction system mechanism 3 to be described later in response to a command to the reagent dispensing arm drive unit 23 of the controller 4. It is possible to rotate so as to draw and move up and down within the circular arc orbit.

The reaction system mechanism 3 includes a plurality of reaction cells 30 ... 30 for filling a sample and a reagent, and the reaction cells 30.
A torus-shaped reaction disk 31 for holding 30 in a circular arrangement when viewed from above the apparatus, and this reaction disk 3
1 based on the control signal CS4 from the controller 4,
It is provided with a reaction disk drive unit 32 that rotates counterclockwise as shown in FIG. 1 and a photometric unit 33 that optically detects the densities of the reaction cells 30.

In this embodiment, the reaction cells 30 ... 30 are
Reaction disk 31
Each unit can be loaded and unloaded. The photometric unit 33 has a multi-wavelength light source, a mirror, a concave diffraction grating, a photodiode array, and the like, and the reaction cell 30 in which the optical axis from the light source to the mirror is rotated ...
By crossing 30, the light quantity corresponding to the density can be converted into an electric signal and output each time. The output signal of the photometric unit 33 is supplied to the controller 4.

FIG. 2 shows the positional relationship between the reaction cells 30 ... 30 when the reaction disk 31 is viewed from above the apparatus. That is, a total of 51 reaction cells 30 ... 30 are arranged in a circle, and unique cell numbers from “1” to “51” are sequentially assigned. These reaction cells 30
The home position of ... 30 is when the reaction cell 30 having the cell number "1" is at the predetermined sample dispensing position (state of FIG. 3).
Is set to. In this home position, the cell number "9" is in the reagent dispensing position, and the cell numbers "43" to "50" (however, "48" is a water blank for checking the light transmittance unique to the cell). Are used in the washing position. Also, when in the home position,
The optical axis of the photometric unit 33 is located between the cell numbers “35” and “36”. In FIG. 2, the counterclockwise arrow A is the rotation direction of the reaction cells 30 ... 30 forming the cell row.

Further, the mechanism 6 of the cleaning system will be described with reference to FIGS.

The sampling probe 13a described above is
It is connected to a sampling pump 41 via a Teflon tube 40. This sampling pump 41
The volume of the built-in syringe can be changed according to the control signal CS11 supplied from the controller 4. The syringe of the sampling pump 41 is normally closed (NC) by the sampling solenoid valve 43 via the tube 42.
Connected to a port. This sampling solenoid valve 43
Has a normally open (NO) port and a common port (COM) in addition to the NC port, and receives a control signal CS12 from the controller 4 to connect between COM and NO ports or COM-.
It is designed to open the flow path between the NC ports. The COM port of the sampling solenoid valve 43 is a tube 44,
It is connected to a discharge port of a probe inner wall cleaning pump 47 via a branch valve 45 and a tube 46. The probe inner wall cleaning pump 47 is also activated while the control signal CS13 supplied from the controller 4 is on. The suction port of the cleaning pump 47 is, as shown in the figure,
It is connected to one of a plurality of discharge ports of a pure water tank 49 via a tube 48. The pure water tank 49 is a container for storing pure water for cleaning, and its supply port is connected to a pure water intake port 51 of the apparatus by a pipe 50. Pure water produced by a pure water producing apparatus PW provided separately is supplied to the pure water intake port 51.

The above-mentioned flow path is filled with pure water in a normal state (that is, an operating state in which pure water has not run out). Then, when the probe inner wall cleaning pump 47 is activated by a command from the controller 4, pure water is supplied from the pure water tank 49 toward the flow path of the branch valve 45. At this time, if the sampling solenoid valve 43 is not operating, COM
Since the space between the NO ports is "open", the pure water tank 49
To the drain pipe 52 side. When the sampling solenoid valve 43 is operating, the COM-NC port is “open”, so that the flow path from the pure water tank 49 to the sampling probe 13a is open.

The NO port of the sampling solenoid valve 43 is connected to the low-concentration waste liquid tank 54 via the drain pipe 52 and its collecting pipe 53. The waste liquid in the low concentration waste liquid tank 54 is drained to the outside of the device.

Further, as the mechanism 6 of this cleaning system, a sampling probe cleaning pool 60 for cleaning the sampling probe 13a is installed. As shown in FIG. 1, the sampling probe washing pool 60 is located between the sampler 11 and the reaction disc 31,
It is installed in an arcuate locus drawn by the tip of the sampling arm 13. This sampling probe washing pool 6
Reference numeral 0 has a cylindrical body into which the sampling probe 13a can be loosely inserted, and a pure water injection port is formed in the upper part of the cylindrical body and a drain port is formed in the bottom part. The drainage port is connected to the low-concentration waste liquid tank 54 via a drain pipe 61, and the drainage in the cleaning pool 60 flows down to the low-concentration waste liquid tank 54 due to the difference in gravity. The pure water injection port of this cleaning pool 60 is connected to one of the discharge ports of the pure water tank 49 via a tube 62, and the tube 6
A one-way valve 63 and a washing pool water supply pump 64 are sequentially inserted in the middle of 2. This wash pool water pump 64
Is a control signal CS1 for rotation / stop from the controller 4.
4 is a centrifugal pump driven by 4. Therefore, when the water supply pump 64 rotates, pure water is supplied from the pure water tank 49 to the pure water injection port of the sampling probe cleaning pool 60.

Next, the flow path of the reagent probe 22a will be described. The reagent probe 22a is connected to a reagent pump 71 via a Teflon tube 70. This reagent pump 71 also has a control signal CS1 from the controller 4.
According to 5, the volume of the built-in syringe can be changed. The syringe of the reagent pump 71 is connected to the normally closed (NC) port of the reagent solenoid valve 73 via the tube 72. The reagent solenoid valve 73 is normally open (NO) in addition to the NC port.
Controller 4 with port and common port (COM)
It receives the control signal CS16 from and opens and closes like the sampling solenoid valve 43. COM of this reagent solenoid valve 73
The port is connected to the branch valve 45 by the tube 74, and reaches the discharge port of the probe inner wall cleaning pump 47 via the tube 46. That is, the cleaning pump 47 is connected to the pure water tank 49. This flow path is also filled with pure water in the normal state.

The NO port of the reagent solenoid valve 73 is connected to the drain pipe 82, and is connected to the low-concentration waste liquid tank 54 via the collecting pipe 53.

Therefore, if the reagent solenoid valve 73 is not operated, the flow path from the pure water tank 49 to the drain pipe 82 side is communicated, and if the reagent solenoid valve 73 is operated, the pure water tank 49 is removed. A flow path to the reagent probe 22a opens.

Further, a reagent probe washing pool 90 for washing the reagent probe 22a is installed. This reagent probe washing pool 90 is, as shown in FIG.
A position between the reagent storage 20 and the reaction disc 31,
The reagent dispensing arm 22 is installed within an arcuate rotation locus drawn by the tip of the arm. This reagent probe washing pool 90
Like the sampling probe cleaning pool 60, it has a cylindrical body into which the reagent probe 22a can be loosely inserted, and a pure water injection port is formed in the upper part of this cylindrical body and a drain port is formed in the bottom part. The drainage port is connected to the low-concentration waste liquid tank 54 via a drain pipe 91, and the drainage in the cleaning pool 90 flows down to the low-concentration waste liquid tank 54 due to the difference in gravity. The pure water injection port is connected to the pure water tank 49 via the tube 92.
A one-way valve 93 and a washing pool water supply pump 94 are sequentially inserted in the middle of the tube 92. The cleaning pool water supply pump 94 is a centrifugal pump driven by a rotation / stop control signal CS17 from the controller 4. Therefore, when the water supply pump 94 rotates,
Pure water is supplied from the pure water tank 49 to the pure water injection port of the reagent probe cleaning pool 90.

Further, a cleaning unit 100 is installed as the mechanism 6 of this cleaning system (see FIG. 1). The cleaning unit 100 is installed at a position facing the reaction disk 31 from above, and has six cleaning nozzles 101a ... 101a, 1
Suction nozzle 101b and one drying rod 10
The cleaning elevator 101 holding 1c can be moved up and down by the cleaning elevator drive unit 102.
The cleaning elevator drive unit 102 moves up and down in response to the control signal CS18 from the controller 4, and in the lowered state, the nozzles 101a to 101c are in the reaction cells 30 ... 30 located at the cleaning position (see FIG. 2) at that time. It can be taken down.

Cleaning nozzle 101a of cleaning unit 100
Each of the ... 101a has a drain port and an injection port. Each drain port has a drain tube 103 ...
The washing pump 104 is connected to six of the eight drainage syringes 105 ... 105 via 103. This washing pump 104 is composed of the above eight drainage syringes 105.
... 105 and 6 water supply syringes 106 ... 106,
It has a drive unit (not shown) integrally. This drive unit receives the control signal CS19 supplied from the controller 4,
The plungers of all the syringes 105 ... 105, 106 ... 106 can be driven collectively (that is, the plungers can be operated from the top to the bottom or from the bottom to the top) so that the liquid can be sucked into the syringe or discharged from the syringe. There is.

The above six drainage syringes 105 ... 105
Of the five, except for the first one, five are connected to the low-concentration waste liquid tank 54 via a collecting pipe 107 and a drain tube 108 in the cleaning pump 104. Therefore, when the cleaning pump 104 operates, the cleaning nozzles 101a ... 10
The waste liquid is drained from the drain port 1a to the low-concentration waste liquid tank 54. In addition, one drain syringe 1 at the top of the rest
05 is a high-concentration waste liquid tank 1 via a tube 119A.
It is connected to 19B.

Further, one suction nozzle 101b of the cleaning elevator 101 is provided with eight drain syringes 105 of the cleaning pump 104 by the drain tube 109.
... 105, and reaches the low-concentration waste liquid tank 54 via the collecting pipe 107. Therefore, by operating the cleaning pump 104, the waste liquid sucked by the suction nozzle 101b is drained to the waste liquid tank 54.

One dry rod 10 of the cleaning elevator 101
1c includes a pipe having a small diameter hole in its peripheral wall, and a water-absorbing member that covers the periphery of this pipe, and the pipe is connected to the low-concentration waste liquid tank 54 via a drain tube 110. There is. A vacuum pump 111 is inserted in the middle of the drain tube 110. This vacuum pump 111
Receives the control signal CS20 from the controller 4, rotates, and sends the waste liquid absorbed by the drying rod 101c to the waste liquid tank 54.

On the other hand, of the six water-absorbing syringes 106 ... 106 of the cleaning pump 104, four are first through the tubes 112 ... 112, respectively, as shown in FIG.
The sixth to sixth cleaning nozzles 101a ... 101a are connected to the ejection ports. The input sides of the six water-absorbing syringes 106 ... 106 are all connected to a pure water tank 49 via a branch pipe 113 and a tube 114. Therefore, when the cleaning pump 104 is operated, the first one from the pure water tank 49,
Pure water is supplied to the injection nozzles of the fourth to sixth cleaning nozzles 101a ... 101a.

Further, the remaining two suction pumps 106, 106 of the washing pump 104 are connected to the alkaline detergent syringe 116a and the acidic detergent syringe 116b of the detergent pump 116 via the tubes 115, 115 as shown in the figure. There is. This detergent pump 116 has, in addition to the two detergent syringes 116a and 116b, a drive unit (not shown) that is activated by the control signal CS21 from the controller 4, and when operating, both syringes 116a and 1
16b plungers are actuated together.

Both of the above detergent syringes 116a, 116
b, through the tubes 117 and 117, 2 from the beginning,
The third cleaning nozzles 101a and 101a are respectively connected to the ejection ports. Tube 11 leading to these two jets
In the middle of 7, 117, an alkaline detergent bottle 118a and an acidic detergent bottle 118b are branched and inserted, respectively. For this reason,
When the cleaning pump 104 and the detergent pump 116 are simultaneously operated, the diluted alkaline and acidic detergents are supplied to the injection ports of the second and third cleaning nozzles 101a and 101a, respectively. When only the cleaning pump 104 is operated, the cleaning nozzles 10 from the pure water tank 49 are removed.
Pure water is supplied to the injection ports of 1a and 101a, respectively.

The pure water tank 49 described above is equipped with a float switch 120 for detecting the depletion of pure water. The float switch 120 has a magnetic detection circuit, for example, and is a switch that supplies a predetermined deionized water signal WT to the controller 4 when the water level of deionized water drops to a specified level at which depletion of deionized water can be determined. ..

Inside the reaction disk 31, constant temperature water having a constant temperature (for example, 37 degrees Celsius) is circulated. Therefore, the centrifugal pump 123 (see FIG. 3),
A constant temperature unit 124, a collecting pipe 125, and a branch pipe 126 (see FIG. 4) are provided.

Further, returning to FIG. 1, the input / output mechanism 5 is
An operating unit 130 operated by an operator and giving a command, a monitor 131 for displaying and outputting operation information, detection data, and measurement results, and a printer 132 are provided.

Further, the controller 4 is constructed by mounting a microcomputer. That is, the controller 4 includes a central processing unit (CPU) 140, a ROM 141 storing a predetermined control processing procedure, a RAM 142 capable of storing operation data and the like, an interface circuit 143, a timer (not shown). Is equipped with. ROM
Reference numeral 41 stores a processing procedure described later as a program. As a result, the controller 4 repeats the predetermined processing procedure, and the operation command of the operation unit 130 and the photometry unit 33.
In response to the photometric data and the detection signal of the float switch 120, the above-mentioned various drive units, pumps, etc., that is, the sampler drive unit 12, the sampling arm drive unit 14, the sampling pump 41, the sampling solenoid valve 43, the probe inner wall cleaning pump. 47, washing pool water absorption pump 64,
94, reaction disk drive unit 32, cleaning elevator drive unit 102, reagent dispensing arm drive unit 23, reagent pump 71,
Reagent solenoid valve 73, washing pump 104, detergent pump 11
6. Control the vacuum pump 111 and output the result to the monitor 131 and the printer 132.

The information provided by the operator via the operation unit 130 includes the measurement conditions such as the sample dispensing amount, the reagent position, the reagent dispensing amount, the measurement wavelength, the item to be measured, and the sampler 11
There are sample positions, the number of samples, and sample IDs placed in the. The conditions and information thereof are stored in the RAM 142, and
It is also displayed on the monitor 131.

The CPU 140 can execute various programs stored in the ROM 141 by time division processing (TSS) using the timekeeping of a built-in timer. When a plurality of programs are being executed by this time division processing, those programs are apparently being processed simultaneously. These programs include a main program that directs and integrates the measurement operation (see FIGS. 5 and 6 described below), a sample dispensing sequence program (see FIGS. 9 and 10 described below) that is responsible for sample dispensing, and reagent dispensing. Reagent dispensing sequence program (see Fig. 1 to be described later)
1 and 12) and a probe inner wall cleaning sequence program for cleaning the inner wall of the probe (see FIG. 13 described later).
And a reaction disk sequence program (see FIG. 14 described later) for controlling the reaction disk and an arithmetic processing program (see FIG. 15 described later) for obtaining the measurement result.

The data stored in the RAM 142 is as follows.
As will be described later, a sample counter that counts the sample, reaction cell information that stores the sample number being measured and the deionized water mark corresponding to each reaction cell 30, the reaction cell number at the sample dispensing position, and the photometric unit 33. The measured light quantity, measurement item, measurement parameter, and the like are applicable.

Next, the operation of this embodiment will be sequentially described for each program.

The operator arranges the sample to be measured in the sampling cup 10 on the sampler 11 and presses the start button of the operation unit 130, whereby the sample shown in FIGS.
The processing of the main program shown in is automatically started.

First, the CPU 140 executes step 1 of FIG.
At 50 and 151, the detection signal WT of the float switch 120 in the pure water tank 49 is read, and based on the read value, it is determined whether or not the pure water has run out (the pure water tank 49 does not have a specified level of pure water). When it is determined in step 151 that the pure water is exhausted (YES), the process proceeds to step 152, and the priming operation subroutine (see FIG. 7) is started. In addition, it is not running out of pure water (NO)
In the case of, the step 152 is skipped and the process is directly shifted to the step 153.

Now, referring to FIG. 7, the priming operation will be described. This priming operation is for calling pure water into the pure water tank 49 from the pure water producing device PW separately provided. The CPU 140, in step 190 of FIG.
The control signal CS18 is supplied to the cleaning elevator driving unit 102 to instruct the cleaning elevator 101 to descend. As a result, each of the nozzles 101a ... 101c has a reaction cell 30 ... 3 located below the cleaning elevator 101 at that time.
Get off in 0. Then, the CPU 140 proceeds to step 191.
Then, the processing is transferred to, and the cleaning pump 104 is controlled by the control signal CS19.
As a result, the water supply syringes 106 ...
Pure water is sucked from 9 and drain syringe 105 ... 1
05 is operated so as to suck the waste liquid from the reaction cells 30 ... 30 having the nozzles inserted therein. Next, in step 192, the cleaning pump 104 is controlled by the control signal CS19 to conversely discharge the pure water sucked from the water supply syringes 106 ... 106 and discharge the waste liquid sucked from the drainage syringes 105 ... 105. To operate. The air in the flow path is discharged by the series of suction and discharge cycles, and the negative pressure causes pure water to be drawn in from the separate pure water producing apparatus PW.

Then, the process proceeds to step 193 and the CPU 1
40 reads the detection signal WT of the float switch 120 and judges whether or not there is pure water. By this judgment,
The processes of steps 191 and 192 are repeated until the pure water of a specified level or higher is accumulated in the pure water tank 49, and the pure water is continuously attracted. If the result of the determination in step 193 is YES, that is, if there is pure water, the CPU 1
40 performs the processing of step 194 and thereafter.

First, in step 194, the work counter CNT = 0 is initialized. Next, at step 195, as in the case of step 191, the suction of pure water and waste liquid by the cleaning pump 104 is commanded, and at step 196, as in step 192, the discharge of pure water and waste liquid by the cleaning pump 104 is commanded. Ordered. Further step 1
In 97, the work counter CNT is incremented by 1, and in step 198, it is determined whether or not the count value of the work counter CNT = 6. In the case of NO in this determination, the process returns to step 195 and the above steps are repeated. This series of inhalation and ejection processes confirms that air that may remain in the flow path from the pure water tank 49 to the water supply syringes 106 ... 106 is expelled, even if pure water is once determined to exist. This is an operation, and the above count value =
The threshold value of 6 is set so that the volume of air in the flow path can be discharged.

If YES is determined in the above step 198, the CPU 140 proceeds to step 199 and the CPU 140 pulls up the cleaning elevator 101 and the cleaning elevator driving section 102.
Command.

As described above, by the subroutine of priming water shown in FIG. 7, priming water when there is a depletion of pure water before the measurement operation and air discharge in the flow path associated with the priming water are surely executed.

Next, the CPU 140 returns to FIG. 5 to perform the processing of step 153 and thereafter. Specifically, in step 153, the return cell number RS (: reaction cell number at the sample dispensing position when the pure water runs out) is cleared (=
0) Further, in step 154, the sample counter SCNT (count value of the number of samples) is cleared (= 0).

Next, in steps 155 and 156, the reaction cell information is shifted by one cell, and the information at the head position in the reaction cell information is cleared. As shown in FIG. 8, when the cell position of the sample dispensing position is set to “1”, the reaction cell information is 51 up to “51” in the counterclockwise direction.
It is table storage information consisting of a sample number preliminarily given by the operator and a deionized water mark automatically given by the apparatus for the sample reaching each cell position (see FIG. 2). The processing of steps 155 and 156 will be described later with reference to step 51.
The whole of the individual reaction cells 30 ... 30, that is, the reaction disk 31.
Is performed for each cycle of rotating counterclockwise by "1 rotation + 1 cell", and is performed for storing a new sample for each cycle.

Then, in step 157, the CPU 1
40 determines whether or not the above-mentioned return cell number RS = 0. This judgment is to check whether or not pure water has run out since the start of measurement. In this judgment, if the return cell number RS = 0 (YES), step 1
In step S58, it is determined whether or not the count value of the sample counter SCNT described above is smaller than the number of samples (: the number arranged in the sampler 11 by the operator and designated in advance by the operator). This judgment is to judge whether or not the measurement is performed by the number of samples. If this determination is YES, that is, if the measurement of the samples arranged in advance has not been completed, the process proceeds to steps 159 and 160. Of this, step 1
At 59, the sample number is set at the beginning of the reaction cell information. In step 160, the count value of the sample counter SCNT is incremented by "1". After that, the process shifts to the sequence processing after step 161.

However, the judgment in step 157 is NO.
(Pure water has run out in the past) or Step 158
If the determination is NO (measurement for the number of samples is completed), the processing of step 159 and step 160, that is, the preparatory work for the measurement of the next cycle is not performed, and the step 16 is directly performed.
Move to 1. As a result, the preparation work for the next measurement is automatically stopped when the pure water has run out.

The CPU 140 executes steps 161-165.
Then, various sequence programs are sequentially started at timings when they can be regarded as almost simultaneous. Of this, step 161
Then, the sample dispensing sequence program shown in FIGS. In step 162, a reagent dispensing program shown in FIGS. Further, in step 163, the probe inner wall cleaning sequence program of FIG. 13 described later, and in step 164 the reaction disk sequence program of FIG. 14 described later,
Next, at step 165, the density calculation programs shown in FIG. 15 which will be described later are executed.

Next, in step 166, the reaction cell number x (: the number of the reaction cell at the sample dispensing position) is decremented by "1". When the reaction disk 30 is at the home position, the reaction cell with the reaction cell number x = 1 comes to the sample dispensing position (cell position 1) (see FIGS. 2 and 8). Next, at step 167, it is judged if the reaction cell number x = 0 or not, and if YES, the routine proceeds to step 168, where the reaction cell number x = the total number of reaction cells (“5” in this embodiment).
1 "). If no, step 168
Skip the processing of. When the processing such as dispensing at the home position is completed by the above processing of steps 166 to 168, the reaction cell number x is decreased from the maximum number to the smaller number, 5
1, 50, 49, ..., 1 are sent one by one.

Next, at step 169, the CPU 140
Is delayed by a system cycle (here 18 seconds).

Next, the routine proceeds to step 170, where it is judged whether or not the return cell number RS = 0 (that is, whether or not pure water has run out in the past). When this determination is YES, that is, when it is determined that there is no depletion of pure water in the past, further step 17
The process proceeds to 1 and it is determined based on the detection signal WT of the float switch 120 whether or not the pure water is currently running out. If the determination of the depletion of pure water is YES (depletion of pure water), the following error processing subroutine 172 is executed. If NO (normal state), the subroutine 17
Skip 2

The error processing of the subroutine 172 will be described with reference to FIG. First, when it is confirmed in step 171 that pure water has run out, in step 205 of the error processing subroutine, the reaction cell number x is set in the return cell number RS. This process is for determining to what position the reaction disk 31 should be returned for the next measurement in the normal state. Next, in step 206, an error mark (= 1) for running out of pure water is set in the reaction cell information of all reaction cells 30 ... 30 from the sample dispensing position to the reagent dispensing position. As a result, if the reagent is dispensed as it is, the pure water is exhausted in the flow path of the syringe water and air is contained, and the dispenser accuracy of the air may lower the dispense accuracy of the reagent amount. It is possible to mark reaction cells 30 ... 30 in which reagent dispensing is not possible. After this, step 173 of the main program
Return to.

Returning to step 173 of the main program, it is judged whether or not there is any reaction cell information including the sample number. That is, it is determined whether or not the measurement is completed. If this determination is NO, that is, if the measurement has not been completed, the process returns to the step 155, and the above-described processing is repeated every one system cycle (here, 18 seconds). If the result of the determination in step 173 is YES, that is, if all the measurements have been completed (however, the concentration is actually calculated only for those having no pure water error mark, as will be described later), the process proceeds to step 174 and subsequent steps.

In step 174, it is again determined whether or not the return cell number RS = 0. As a result, YES (RS
= 0), and when the pure water has not run out in the past, the processing is ended as it is. However, NO (RS>
If it is 0) and it is determined that the pure water has run out in the past, the processes of steps 175 to 179 are performed. In step 175, “return pitch number RP = return cell number RS
-Calculate the amount of reaction cell number x ". In step 176, it is determined whether or not the calculated return pitch number RP <0.
Thereby, the returning direction of the reaction disk 31 can be known. However, since the reaction disc 31 is always rotated counterclockwise in this embodiment, if the return pitch number RP <0, in step 177, "return pitch number RP = return pitch number RP + reaction cell total number" is calculated. Calculate As a result, the counterclockwise direction can always be dealt with. Then step 178
Then, it is determined whether or not the return pitch number RP = 0, and YES.
In the case of No. 3, since the deionized water has run out in the final reaction cell 30 containing the measurement sample, there is no need to return the reaction disk 31, and the process is ended.

However, if NO in step 178, the CPU 140 rotates the reaction disk 31 counterclockwise by the calculated return pitch number RP to bring the reaction disk 31 to the position where pure water has run out. Return and end the process.

Next, the sequence program will be sequentially described.

First, the sample dispensing sequence program will be described with reference to the flowcharts of FIGS. 9 and 10 and the timing chart of FIG. When this sequence program is activated, the CPU 140 determines in step 210 of FIG. 9 whether or not there is a sample number. This processing is performed by, for example, a flag determination as to whether or not the sample number is included (stored) in the item of the sample number of the reaction cell information at the sample dispensing position. YES in this process (with sample number)
If the determination is made in step 2, the process proceeds to step 211, and it is determined whether or not there is a pure water error. This determination is made based on whether or not a mark "1" (flag) indicating no pure water (error) is added to the item of the pure water error mark in the reaction cell information at the sample dispensing position. Y in this judgment
When it becomes ES (that is, pure water is in a normal state), the sample dispensing process after step 212 is started.

[0079] In step 212, CPU 140 supplies a control signal CS2 to the sampling arm drive section 14, (see _{a 1} in FIG. 16) to rotate to start the sampling arm 13 to the sample suction position of the sampler 11. Next, in step 213, the CPU 140 supplies the control signal CS11 to the sampling pump 41 to command the suction of a predetermined amount of air (for example, 5 μl) (see a _{2 in} FIG. 16). Accordingly, the rotation of the sampling arm 13 and the air suction are performed in parallel. Here, a predetermined amount of air is sucked in to form a layer that isolates the pure water from the sample.

Next, at step 214, it is judged whether or not the sampling arm 13 has stopped after rotating to the sample suction position. If NO in this determination, the rotation of the sampling arm 13 is continued, and if YES, the process proceeds to step 215. In step 215, the control signal CS18 is supplied to the sampling arm driving unit 14 to instruct the sampling arm 13 to descend into the sampling cup 10 of the sampling probe 13a. That is, when the sampling arm 13 reaches the sample suction position, it immediately descends (see a _{3 in} FIG. 16).

In [0081] Next step 216, the sampling pump 41, and supplies a control signal CS11 to lower the plunger further suction the sample in the sample cup 10 in the sample suction position (see _{a 4} in FIG. 16) ..
The amount of sample inhaled here is the total amount of the sample amount, tube dummy amount, and backlash removed amount actually required for measurement. After that, in step 217, a delay of a predetermined time (for example, 0.1 seconds) is applied to wait. This delay time is to wait for the sample to be completely sucked into the sample probe 13a in consideration of the viscosity of the sample.

In [0082] Next step 218, slightly let pushes up the plunger by supplying a control signal CS11 to the sampling pump 41, causes the discharge of the backlash elimination fraction of the sample (see _{a 5} in FIG. 16).

When this backlash removal is completed, the CPU
140 immediately at step 219, the sampling arm 13 to the sampling arm drive section 14, i.e., to pull up the sampling probe 13a (see _{a 6} in FIG. 16). Thereafter, at step 220, rotating the sampling arm 13 to just above the position of the sampling probe cleaning pool 60 (see _{a 7} in FIG. 16). When the rotation is completed, CPU 140 proceeds to the processing in step 221, commands the descent of the sampling probe 13a to the sampling arm drive unit 14 (see _{a 8} in FIG. 16). As a result, the tip of the sampling probe 13a is immersed in the pure water in the cleaning pool 60. Thereafter, pulling from the washing pool 60 of the sampling probe 13a is commanded at step 222 (see _{a 9} in FIG. 16). Through the processing of steps 221, 222, the sampling probe 1
The excess sample attached to the tip of 3a is removed.

Then, the process proceeds to step 223, where the CPU 1
40 rotates the sampling arm 13, on the reaction cell 30 located at the sample dispensing position at which time the reaction disk 31, that is, until the sample discharge position (see a ₁₀ in FIG. 16). Then, (see _{a 11} in FIG. 16) lowers the sampling probe 13a at step 224, the control signal at step 225 to the sampling pump 41 CS11
Is supplied to raise the plunger, and the sample is discharged (see a _{12 in} FIG. 16). The discharge amount here is the sample amount.

When the discharge of the sample, that is, the injection is completed in this way, the CPU 140 pulls up the sampling probe 13a and cleans the pool 6 in steps 226 and 227.
The rotations up to 0 are sequentially ordered (see a ₁₃ and _{14 in} FIG. 16).

Then, in step 228, the CPU 1
40 sends a control signal CS12 to the sampling solenoid valve 43 to activate the sampling solenoid valve 43 (FIG. 16).
Reference of _{a 15).} As a result, the NC contact of the solenoid valve 43 is opened and the NO contact is closed, so that the sampling syringe of the sampling pump 41 and the flow path of the probe inner wall cleaning pump 47 are connected. Almost in parallel with this processing, in step 229, the control signal CS is sent to the cleaning pool feed pump 64.
14 is supplied, and this water supply pump 64 is operated (on) (see a _{16 in} FIG. 16). As a result, the sampling probe 13a can be prepared for cleaning.

When this cleaning preparation is completed, step 23
0, the sampling probe 13a is lowered while the cleaning position (see _{a 17} in FIG. 16). Then, the process proceeds to step 231, the plunger of the sampling pump 41 is raised, and returned to its initial position. As a result, the liquid remaining in the probe 13a is discharged (a in FIG. 16).
₁₈ ).

Further, by the standby process of step 232, the state after the residual liquid is discharged is waited until the probe inner wall cleaning pump 47 completes the discharge for a predetermined time (see c ₁ in FIG. 16 described later). When the waiting time has elapsed, step 23
The steps 3 and 234 are sequentially performed, and the sampling solenoid valve 43 is deactivated (off) and the cleaning pool water supply pump 64 is deactivated (off). Further, step 235
In sampling probe 13a after the cleaning is raised (see _{a 19} in FIG. 16).

As a result, one cycle of sample dispensing and sampling probe cleaning instructed by the main program is completed.

By the way, when it is judged in the steps 210 and 211 that there is no sample number or there is no pure water (pure water is exhausted), steps 212 to 235.
Skip the process up to and end directly.

To summarize the operation of the above sample dispensing sequence, a predetermined amount of air is sucked into the sampling probe 13a while rotating the sampling arm 13 to the sample dispensing position. After that, the sampling probe 13a is lowered into the sampling cup 10 and a predetermined amount of the sample is sucked, and then the backlash is removed. Then, pull up the sample probe 13a,
After rotating to the washing pool 60, the probe 13a is lowered into the washing pool 60 to remove the excess sample attached to the outer circumference of the probe. Then, the sample probe 13a
Is pulled up and rotated onto the reaction cell 30, and then lowered into the reaction cell 30 to discharge a predetermined amount of sample. After this, the sampling probe 13a is pulled up from the reaction cell 30 and rotated back to the washing pool 60,
The sampling solenoid valve 43 is activated. Probe 1
While lowering 3a into the washing pool 60, the water supply pump 6
4, pure water is supplied into the pool 60. afterwards,
The plunger of the sampling pump 41 is returned to the initial position, and after cleaning the inner wall of the probe, the probe 13a is pulled up and stops on the cleaning pool 60.

Next, the reagent dispensing sequence program will be described with reference to the flowcharts of FIGS. 11 and 12 and the timing chart of FIG. When this sequence program is activated, the CPU 140 causes the step 240 of FIG.
In step 24, it is determined whether or not there is a sample number, and step 24
In the processing of 1, it is judged whether or not there is a pure water error. These processes 240 and 241 are the same as the processes (steps 220 and 221) in the sample dispensing sequence described above. Therefore, when it is determined that there is a sample number and there is no pure water error, the process proceeds to step 242 and subsequent steps.

At step 242, a standby is commanded until the reagent dispensing start time. After this waiting, step 243
The process, as the reagent dispensing arm 22 is rotated to a reagent bottle position measurement items, the control signal CS3 to the reagent dispensing arm drive section 23 is issued (see b ₁ in FIG. 16). Further, in parallel with the rotation of the reagent dispensing arm 22, the control signal CS15 is sent to the reagent pump 71 by the process of step 244, and the plunger of the reagent pump 71 is driven in the stroke extension direction. Therefore, intake a given amount of air for pure water Reagent isolated into reagent probe 22a (e.g. 10μ liters) is commanded (see b ₂ in FIG. 16). Then in step 245,
It is determined whether or not the rotated reagent dispensing arm 22 has stopped, and when it has stopped, the processing of step 246 and thereafter is started.

[0094] In step 246, by controlling the reagent dispensing arm drive section 23, the reagent probe 22a is lowered into the desired reagent bottle 21 (see _{b 3} in FIG. 16). When this is completed, in step 247, the reagent pump 7
By supplying the control signal CS15 to 1, the plunger is lowered in the pump 71, the reagent is sucked (see _{b 4} in FIG. 16). The inhalation amount at this time is “inhalation amount = reagent amount + tube / dummy amount + backlash removed amount”. Thereafter, in step 248, a predetermined time (for example, 0.
Wait for 1 second. This waiting takes into consideration the time required for the reagent solution to be completely sucked into the probe due to the viscosity.

Next, the routine proceeds to step 249, where the backlash removed portion of the reagent pump 71 is discharged (FIG. 16).
B ₅ ).

Next, at step 250, the reagent dispensing arm driving section 23 is controlled to control the reagent probe 22.
A command is issued to pull up a (see b _{6 in} FIG. 16). After this pulling up, in step 251, the reagent dispensing arm drive unit 23 is similarly controlled to rotate the reagent probe 22a to above the reaction cell 30 at the discharge position (FIG. 16).
Reference of _{b 7).} As described above, the reagent probe 22a is placed inside the probe 22a by the reagent discharge process of step 252 (the reagent pump 71 is controlled to push the plunger in the stroke reduction direction) with the tip of the reagent probe 22a positioned above the reaction cell 30. The reagent is dropped into the reaction cell 30 (see FIG. 1).
Reference _{b 8} of 6). The discharge amount at this time = reagent amount.

Then, in step 253, the reagent arm 2
2 is commanded to rotate the return to the top of the reagent probe wash pool 90 (see b ₉ in FIG. 16). After this,
In step 254, the reagent solenoid valve 73 is sequentially turned on and the reagent cleaning pool water supply pump 94 is sequentially turned on (see b ₁₀ and _{11 in} FIG. 16). As a result, the flow path from the probe inner wall cleaning pump 47 to the syringe of the reagent pump 71 is connected, and pure water is sprayed and supplied into the cleaning pool 90. At a timing which can be regarded as this substantially simultaneous, the process of step 256, the reagent probe 22a is lowered (see _{b 12} in FIG. 16). Then, in step 257, the reagent pump 71 is driven by the control signal CS15 to return the plunger to the initial position. This allows
The reagent remaining in the reagent probe 22a is the cleaning pool 9
0 is discharged (see b _{13 in} FIG. 16). In this state, the process of step 258 waits until the discharge of the probe inner wall cleaning pump 47 described later is completed.

When the discharge of the probe inner wall cleaning pump 47 is completed, the reagent electromagnetic valve 73 is turned off in step 259, the reagent cleaning pool water supply pump 94 is turned off in step 260, and the reagent probe 22a is operated in step 261. Is commanded to be pulled up (see b _{14 in} FIG. 16).

By the way, when it is judged in the steps 240 and 241 that there is no sample number or there is no pure water (pure water is depleted), steps 242 to 261.
The processing up to is skipped and the reagent dispensing sequence is ended.

When the operation relating to the reagent dispensing sequence described above is summarized, after a fixed time from the start of the operation, the reagent dispensing arm 22 is rotated to the position of the reagent bottle 21 corresponding to the measurement item, and the reagent probe 22a is rotated. A predetermined amount of air is sucked into the inside of the reagent pool 22a, and then the reagent pool 22a is replaced with the reagent bottle 2
Drop it into 1. After this, a predetermined amount of reagent is added to the reagent probe 2
It is sucked into 2a, and the backlash is further removed. Furthermore, after the reagent pool 22a is pulled up and rotationally moved to the position of the reaction cell 30, a predetermined amount of reagent is discharged from the reagent probe 22a. After this discharging and dropping, the reagent probe 22a is rotationally moved to the dedicated cleaning pool 90, and while the reagent probe 22a is being lowered into the pool 90, pure water is passed through the inner wall of the probe for cleaning, and the outer wall is also cleaned. .. Further, the plunger of the reagent pump 71 is operated in the contracting direction to discharge the residual liquid in the syringe. After that, when the cleaning of the inner and outer walls of the reagent probe 22a is completed, the reagent probe 22a is lifted above the cleaning pool 90 and stopped.

Next, the probe inner wall cleaning sequence program will be described with reference to FIGS. 13 and 16. In step 270 of FIG. 13, the CPU 140 determines whether or not the sample number is present by checking whether or not the sample cell number is included in the reaction cell information of the sample dispensing position and the reagent dispensing position. If there is a sample number (YES) in this judgment,
In step 271, it is determined whether or not the return cell number RS = 0. If YES, in step 272, the probe inner wall cleaning start time is waited (for example, 10 seconds). After this waiting, in step 273, the probe inner wall cleaning pump 4
7 is driven by a control signal CS13 and eject the pure water (see _{c 1} in FIG. 16). At this time, as described above,
Since the sampling solenoid valve 43 and the reagent solenoid valve 73 are also turned on, the flow path from the washing pump 47 to the sampling probe 13a and the reagent probe 22a is open, and the pure water tank 49 supplies pure water to the probes 13a and 22a. Is supplied.

After this pure water supply is completed, step 27
In 4, the process waits for a predetermined time (for example, 0.2 seconds), and the process proceeds to step 275. In this step 275, the probe inner wall cleaning pump 47 is made to suck pure water for the next discharge of pure water (see c _{2 in} FIG. 16).

On the other hand, when NO is determined in step 270 (that is, there is no measurement sample) or NO is determined in step 271, the above-described processing of steps 272 to 275 is not executed.

As a result of the above processing, the sampling probe 13a and the reagent probe 22a have their respective washing pools 60.
Pure water is supplied from the cleaning pump 47 to each probe at the timing of being lowered to 90 and 90, and the pure water is discharged from the tip of the probe through its inner wall. As a result, the inner walls of the probes 13a and 22a are cleaned.

Next, the reaction disk sequence program will be described with reference to FIGS. 14 and 16. First, FIG.
In step 280, the CPU 140 determines whether or not the deionized water is exhausted by checking whether or not the return cell number RS = 0. YES in this judgment
In the case of (RS = 0), it is recognized that the pure water is not running out, and the processes from step 281 are sequentially performed.

First, in step 281, the CPU 140
Turns on the control signal CS20 to operate the vacuum pump 111. As a result, air is sucked from the drying nozzle 101c of the cleaning elevator 101. Then, in step 282, the control signal CS is sent to the cleaning elevator driver 102.
18 is sent to lower the cleaning elevator 101 (see d _{1 in} FIG. 16). As a result, the cleaning elevator 101
101c are all lowered into the reaction cells 30 ... 30 that are currently under the elevator.
Therefore, the drying nozzle 101c causes the nozzle 10
The water in the reaction cell 30 containing 1c is sucked up, and the inside of the reaction cell 30 starts to dry. The water thus sucked is discharged to the low-concentration waste liquid tank 49 via the drain tube 110.

Then, in step 283, after setting the work counter W = 0, the processes of steps 284 to 288 are sequentially performed.

At step 284, the control signal CS19 is sent to the cleaning pump 104 to put the pump 104 into the suction mode and the detergent pump 116 is supplied with the control signal CS2.
1 is sent to bring the pump 116 into the suction mode (see d ₂ and d _{3 in} FIG. 16). As a result, the cleaning pump 10
The drainage syringes 105 ... 105 and the water supply syringes 106 ... 106 of No. 4 are pushed down in the stroke extension direction. As a result, the cleaning elevator 10
101 from the total noise 101a ... 101c to the reaction cells 30 ... 3
0 liquid is sucked in, and drainage syringe 105 ... 015
Pure water is sucked into the water supply syringes 106 ... 106 from the pure water tank 49. In parallel with this, the alkaline detergent and the acidic detergent and the pure detergent in the tubes 115 and 115 are respectively sucked into the alkaline detergent syringe 116a and the acidic detergent syringe 116b from the alkaline detergent bottle 118a and the acidic detergent bottle 118b. Is diluted.

Next, at step 285, the process waits for a predetermined time (for example, 0.2 seconds) in consideration of the delay of the flow of drainage water, pure water, and detergent due to the flow path resistance. Then, at step 286, the CPU 140 controls
The washing pump 104 and the detergent pump 116 are set to the discharge mode (see d ₄ and d _{5 in} FIG. 16). This allows
The plungers of the drainage syringes 105 ... 105 and the water supply syringes 106 ... 106 of the cleaning pump 104 are pushed up in the stroke contracting direction. As a result, pure water from the water supply syringes 106 ... 106 is discharged, so that the pure water is discharged into the reaction cells 30 ... 30 from the first, fourth to sixth nozzles 101a ... 101a and the detergent syringe 116a. , 116b of diluted detergent a few
From the second nozzle 101a, 101a to the reaction cells 30, 3
It is discharged within 0. On the other hand, of the waste liquid accumulated in the drainage syringes 105 ... 105 of the cleaning pump 104, the first waste liquid from the beginning is discharged as a high-concentration waste liquid to the high-concentration waste liquid tank 119B through the tube 119A, and the second to sixth Is discharged as a low-concentration waste liquid to the low-concentration waste liquid tank 49 through the collecting pipe 107 and the drain tube 108. Further, the waste liquid sucked from the suction nozzle 101b is also discharged by the drainage syringe 105 to the low-concentration waste liquid tank 4
It is discharged to 9.

Then, in step 287, step 28
The work counter W cleared in 3 is incremented by "1". Then, in step 288, the work
It is determined whether or not the count value of the counter W has reached a predetermined number (“3” in this embodiment). NO in this judgment
In the case of, it is assumed that the specified number of cleanings has not yet been reached,
The process proceeds to step 289, waits again for a predetermined time (0.2 seconds as in step 285), and then returns to step 284. Then, steps 284 to 287
The above steps 284 to 289 are repeated until the count value of the work counter W = 3.

When a YES determination is made in step 288, it is considered that the cleaning has been performed the specified number of times in one cycle (see d ₆ and d _{7 in} FIG. 16), and the processing in steps 290 and 291 is performed. I do. In step 290, a command is issued to raise the cleaning elevator 101 (d in FIG. 16).
₈ ). In step 291, the vacuum pump 111 that has been rotating until then is instructed to stop.

After this, the process proceeds to step 292, and the CPU
Reference numeral 140 designates a standby until the photometry start time. Then, when the photometric start time comes, in step 283, the control signal CS4 is sent to the reaction disk drive unit 32, and the reaction disk 31 is rotated by the sum of "1 rotation" and "1 reaction cell pitch". Thereby, the reaction cell 30 ...
The light beam of the photometric unit 33 of 30 is traversed, and the change in density is detected as a change in light amount.

However, if NO in step 280, that is, if the return cell number RS is not "0", it is determined that the pure water has run out, and the steps 281 to 281 described above are performed.
Instead of performing the processing of 291, directly execute steps 292, 29.
Process 3 is performed.

In summary of the series of processes shown in FIG. 14 described above, in a normal state where no depletion of pure water occurs, the reaction disks 30 ... 30 located below the cleaning elevator 101 at that time are cleaned. The nozzles 101a to 101c of the elevator 101 are lowered, and cleaning is performed a predetermined number of times. Thereafter, while rotating the reaction disk 31, one photometric data is collected for each of the reaction cells 30 ... 30 containing the sample and the reagent. The positions of all reaction cells 30 ... 30 after this data collection are advanced by one cell pitch in the rotation direction compared to before the data collection (that is, before disk rotation). Thereafter, when the reaction disk sequence is activated, the above-mentioned processing is repeated again at the new position.

On the other hand, when the state of running out of pure water is detected, the series of elevator lowering and cleaning processes described above are not performed, and the reaction disk 31 is simply waited until the photometry time.
To rotate. Therefore, the photometric unit 33 collects only the photometric data.

Finally, the arithmetic processing program will be described with reference to FIG.

In step 300 of FIG. 15, whether or not there is a measurement sample is determined by whether or not the sample number is included in the reaction cell information at the high-concentration cleaning position. YES in this judgment
That is, if the sample is present, then in step 301, it is determined whether or not there is a pure water running out mark in the reaction cell information of the reaction cell 30 at the high-concentration cleaning position related to the presence of the sample. If the result of this judgment is NO, that is, if no error has occurred, the routine proceeds to step 302, where the concentration of a predetermined measurement item is calculated using the photometric data group obtained so far. However, if the determination in step 301 is YES, that is, if it is determined that an error has occurred, the density calculation in step 302 is not performed.

Then, the processes of steps 303 and 304 are performed. In step 303, the sample number and the calculation result of the concentration calculation are edited. In step 304, the deionized water mark = 1 in the reaction cell information is edited as an abnormal mark.

Next, in step 305, the editing results of the above steps 303 and 304 are output to the printer 132.

If NO in step 300, that is, if there is no measurement sample, steps 301 to 305
To end the sequence.

Next, the operation based on the above-mentioned processing will be summarized.

When the operator commands the processing of FIGS. 5 and 6, first, it is judged whether or not the pure water has run out. If the pure water runs out, the priming treatment is performed as shown in FIG. To be done. Even if the priming treatment is continued, if the pure water is still running out due to the failure of the pure water producing device PW,
It is judged by the main program that it is out of pure water (Fig. 6).
Step 171). By this automatic processing of priming, temporary depletion of pure water due to forgetting to open the water faucet of the pure water producing device is recovered, measurement can be smoothly and quickly proceeded, and the burden on the operator is significantly reduced.

When this priming treatment is completed, a predetermined measuring treatment is successively carried out. Now, assuming that there is no normal state of running out of pure water, sample dispensing (step 161), reagent dispensing (step 162), probe inner wall cleaning (step 16).
3), the reaction disk control (step 164) and the concentration calculation (step 165) are activated at the timings which can be considered to be almost simultaneous, and are processed in parallel as shown in FIG.
Then, since there is no depletion of pure water, no error processing is performed, and steps 161-165 are performed.
The sequence program is executed once per system cycle to obtain concentration data.

On the other hand, the reaction cell numbers "1", "51" to "1" from the home position with the total number of samples are 40.
3 ”reaction cells 30 ... 30 are sequentially sampled. For example, after the sample dispensing to the reaction cell 30 of the reaction cell number“ 34 ”is completed, the cell position shown in FIG. 17 (that is, the reaction cell number“ 33 ”). It is assumed that the deionized water is detected when the reaction cell 30 of “(1) is rotated to the sample dispensing position” (that is, YES is determined in step 171 of FIG. 6). When this running out of pure water is detected, steps 205 to 205
After the error processing of 207 is performed, as shown in FIG.
Reaction cells 30 ... 30 having reaction cell numbers "33" to "41"
A deionized water mark is added to the reaction cell information for (i.e., deionized water mark = 1). Along with this, the return cell number RS = reaction cell number x = 33 is stored (step 206). This makes it possible to recognize that the accuracy of the quantitative determination of the sample dispensing and the reagent dispensing may be deteriorated due to the depletion of pure water, and that the previous cleaning of the probes 13a and 22a may not be sufficient. ..

In this case, the reaction cell numbers "1" and "5" still remain.
Since the sample numbers are stored in the reaction cell information of "1" to "33" respectively (NO in step 173), FIG.
The processing of steps 155 to 173 relating to the next system cycle is performed with the cell position shown in FIG. Then, in the next cycle, the return number cell RS = 33, which is not "0", the determination in step 157 is NO and the sequence program is directly entered.

Of these, in the sample dispensing sequence of FIGS. 9 and 10, for the reaction cell 30 of the reaction cell number “33”,
Although the measurement sample number has been set by the processing of the previous step 159, the pure water out mark = 1 due to the error processing of step 207, so sample dispensing and cleaning of the sampling probe 13a (FIGS. 9, 10). Steps 212 to 235) are not performed. For the same reason, in the reagent dispensing sequence of FIGS. 11 and 12, reagent dispensing to the reaction cell 30 having the reaction cell number “41” and washing of the reagent probe 22a (steps 242 to 261 in FIGS. 11 and 12) are also performed. Not done Furthermore, FIG.
Also in the inner wall cleaning sequence of No. 2, although the sample number is present, it is determined that the pure water has run out, and the probe inner wall cleaning (steps 272 to 275) is not performed.

Further, since the return cell number RS = 33, the step 281 of FIG.
The processings of ˜291 are not performed, and the reaction disc 31 is rotated by one rotation and one reaction cell pitch after merely waiting until the photometry start time. As a result, the reaction cells "1" and "51" in which the sample and the reagent are dispensed in the normal state
~ Photometric data is obtained for "42", and the reaction disk 31 is advanced by one pitch in preparation for the next cycle (a state rotated by one pitch from FIG. 17).

Further, in the density calculation sequence of FIG.
Since there is no sample number in the reaction cell information of the cell position 43 which is the washing position, the concentration calculation etc. (steps 302 to 3)
05) is not implemented.

Then, as long as there is a sample number in a series of reaction cell information (this information is sequentially shifted every system cycle: steps 155 and 156 in FIG. 5), the above sequence programs are respectively executed. While this process is in progress, especially when the sample number is not set in the reaction cell information at the sample dispensing position (NO in step 210 of FIG. 9), sample dispensing is not performed. Further, when the sample number is not set in the reaction cell information of the reagent dispensing position (NO in step 240 of FIG. 11), reagent dispensing is not performed. Further, in the state of running out of pure water, the inner wall of the probe is not naturally washed (step 271 in FIG. 13).
And NO).

On the other hand, regarding the concentration calculation, even when the reaction disk 31 advances by one pitch, the reaction cell number "1" reaches the cleaning position (here, high-concentration cleaning at the cell position 43) and the photometric data is collected. Until the end can be determined (that is, until YES in step 300 in FIG. 15),
Do not calculate density. Then, when the reaction cell number “1” reaches the high-concentration cleaning position, the concentration calculation is performed for the reaction cell 30. However, for example, when the reaction cells 30 of the reaction cell numbers “41” to “33” reach the high-concentration cleaning position, the deionized water mark of the reaction cell of the reaction cell 30 is 1, so the concentration is The calculation is skipped, and in step 303, the process goes to a process such as editing the deionized water mark = 1 into an abnormal mark.

When the reaction disk 31 rotates one pitch at a time and the reaction cell 30 with the reaction cell number "33" reaches the high-concentration waste liquid washing position (cell position 43) while performing the above-described processing, the steps shown in FIG. By the shift and clear processing of 155 and 156, all the reaction cell information is cleared. Therefore, the reaction disk 31 is rotated clockwise in FIG. 2 until the reaction cell 30 of the reaction cell number “33” reaches the sample dispensing position (cell position 1) by the processing of steps 174 to 179 of FIG. 6 of the main program. To be rotated. As a result, the measurement is completed in a state where the pure water running out position shown in FIG. 17 is automatically restored.

Thus, if the pure water runs out during the measurement, even if the operator does not notice the abnormality, the sample dispensing, the reagent dispensing, and the cleaning operation using the pure water are stopped further. Therefore, less air is sucked into each syringe and the flow path, the idle operation at the time of re-measurement is short, and the total measurement efficiency is improved. In addition, the suspension of a new dispensing operation when running out of pure water reduces the accuracy of quantitative determination of samples and reagents due to the buffering effect of air in the mixed flow channel as in the past, resulting in poor reliability of measurement data. This situation can be avoided in advance. Further, when the deionized water runs out, the reaction disk is automatically returned to the position where the deionized water runs out and stops, so that the secondary disk caused by the residual reagent on the drying rod 101c attached to the cleaning elevator 101 is secondary. Contamination is reliably prevented, rapid re-measurement is possible, and the burden on the operator is reduced.

On the other hand, when the pure water runs out during the measurement, the concentration is calculated only for the reaction cell 30 in which the sample and the reagent can be normally dispensed while the cleaning elevator 101 is pulled up and the cleaning is stopped. For this reason, by stopping the new dispensing operation when deionized water runs out, the buffering effect of air in the mixed flow channel reduces the quantification accuracy of samples and reagents as in the past, and the reliability of measurement data is improved. You can avoid the situation of being scarce. Furthermore, for normal aliquots, the concentration calculation is performed, so even if pure water runs out, it is not necessary to immediately stop the entire measurement, and the number of measurement-stopped cells due to pure water run-out is minimized. Can be suppressed.

When the cell cleaning is stopped due to running out of pure water, the supply of the cell detergent is automatically stopped.
The waste can be eliminated and the operation cost of the device can be suppressed.

Furthermore, since the measurement result output from the printer 132 is marked with an abnormality mark due to running out of pure water, the operator can easily see the sample to be re-measured and the measurement management becomes easy. ..

The main program of the automatic chemical analyzer according to the present invention is not necessarily limited to the programs shown in FIGS. 5 and 6, but the judgment path of step 170 of FIG. 5 is changed as shown in FIG. May be. That is, FIG.
In step 170, it is checked whether or not the return cell number RS = 0. If NO, that is, if pure water has run out in the past, the process proceeds to step 310.
It is judged again based on the switch signal WT of the float switch 120 whether the pure water is exhausted. As a result, if the pure water is exhausted, the process directly proceeds to step 173, but if the pure water is recovered, the return cell number RS = 0 is cleared at step 311 and then the process proceeds to step 173.
As a result, if the deionized water is eliminated during the measurement, the reaction cell 30 marked with the deionized water error mark is skipped, and the measurement can be normally performed subsequently.

Further, the reaction section applicable to the automatic chemical analyzer of the present invention is not limited to the circular reaction disk as described above, but may be simply an endless reaction line. Further, it may be an analyzer that dispenses a sample after dispensing a reagent.

[0138]

As described above, in one aspect of the automatic chemical analyzer according to the present invention, when the deionized water in the deionized water tank is detected and judged, new sample dispensing and reagent dispensing are performed. Injection and cell washing (or cell washing and sample dispensing,
The treatment using pure water such as washing of the probe for reagent dispensing) was stopped, and after the measurement was completed, the reaction part was returned to the position of running out of pure water. Therefore, the waste of the sample and the reagent due to running out of pure water can be eliminated, and the interference between items due to insufficient cleaning with pure water and the contamination due to the residual reagent can be automatically prevented, and the deterioration of the measurement accuracy can be prevented. While it can be eliminated, tracing of the pure water run-off position becomes easy and re-measurement can be speeded up.

In another embodiment, when pure water is exhausted, a mark is attached to the information of the reaction cell in which the sample and the reagent cannot be dispensed, which makes it easy to discriminate between normal and abnormal in the data of the measurement results. The load on the operator is reduced and the preparation for re-measurement is significantly facilitated.

In still another mode, when the depletion of pure water is eliminated during the process of depletion of pure water, the measurement operation in the normal state can be automatically restored automatically. , The operation of the device becomes much easier.

In still another mode, if the pure water runs out at the start of the measurement, the priming process is first performed. Therefore, if the pure water run out is eliminated by this process, it is possible to automatically shift to the normal measurement automatically. The operation of is simplified.

In still another mode, when the pure water is used up, the supply of the detergent used for cleaning is also stopped, so that the waste is eliminated and the operating cost can be reduced.

In yet another mode, the number of concentration calculations is reduced, and the calculation load of the control device is reduced.

As described above, even if the pure water runs out, the damage can be minimized, the total measurement efficiency can be improved, and the deterioration of the measurement accuracy due to the interference between items can be eliminated. On the other hand, the automatic chemical analyzer can significantly reduce the burden on the operator.

[Brief description of drawings]

FIG. 1 is a configuration diagram showing electrical connection of an automatic chemical analyzer according to an embodiment of the present invention.

FIG. 2 is an explanatory diagram showing a relationship between a cell position and a reaction cell number at a home position of a reaction disk.

FIG. 3 is a flow chart showing the flow channel system of the automatic chemical analyzer of the embodiment, which is integrated with FIG.

FIG. 4 is a flow path diagram showing the flow path system of the automatic chemical analyzer of the embodiment, which is integrated with FIG.

FIG. 5 is a flowchart showing a main program integrated with FIG.

FIG. 6 is a flowchart showing a main program, which is integrated with FIG.

FIG. 7 is a flowchart showing a subroutine relating to priming water treatment.

FIG. 8 is an explanatory diagram illustrating reaction cell information for all reaction cells.

9 is a flowchart showing a sample dispensing sequence, which is integrated with FIG.

FIG. 10 is a flowchart showing a sample dispensing sequence, which is integrated with FIG.

FIG. 11 is a flowchart showing a reagent dispensing sequence, which is integrated with FIG.

FIG. 12 is a flowchart showing a reagent dispensing sequence, which is integrated with FIG.

FIG. 13 is a flowchart showing an inner wall cleaning sequence.

FIG. 14 is a flowchart showing a control sequence of a reaction disk.

FIG. 15 is a flowchart showing a sequence of density calculation processing.

FIG. 16 is a timing chart showing the timing of each sequence of the embodiment.

FIG. 17 is an explanatory diagram showing an example of the relationship between the cell position and the reaction cell number when running out of pure water.

FIG. 18 is an explanatory diagram showing an example of reaction cell information related to error processing when pure water is exhausted.

FIG. 19 is a flowchart partially showing an example of a main program according to another embodiment.

[Explanation of symbols]

 1 Mechanism of Sampling System 2 Mechanism of Reagent System 3 Mechanism of Reaction System 4 Controller 5 Input / Output Mechanism 6 Mechanism of Washing System 10 Sampling Cup 11 Sampler 12 Sampler Drive 13 Sampling Arm 13a Sampling Probe 20 Reagent Cabinet 21 Reagent Bottle 22 Reagents Injection arm 22a Reagent probe 30 Reaction cell 31 Reaction disc 32 Reaction disc drive unit 33 Photometric unit 41 Sampling pump 43 Sampling solenoid valve 47 Probe inner wall washing pump 60,90 Washing pool 64,94 Water supply pump 71 Reagent pump 73 Reagent solenoid valve 100 Washing Unit 101 Cleaning elevator 104 Cleaning pump 116 Detergent pump 118a, 118b Detergent bottle 120 Float switch 140 CPU PW Pure water production device

Claims (8)

[Claims] 1. A reaction part that holds a cell row composed of a plurality of reaction cells, and this reaction part is washed from a preset sample dispensing position through a reagent dispensing position or from a reagent dispensing position through a sample dispensing position. The reaction part moving means for moving in the direction of the position, the sample dispensing means for dispensing the sample to the reaction cell located at the sample dispensing position, and the reagent dispensing to the reaction cell located at the reagent dispensing position. The reagent dispensing means, a cleaning means for cleaning the reaction cell located at the cleaning position with at least pure water, and the pure water supplied from the pure water manufacturing apparatus connected to the external pure water manufacturing apparatus. A tank for storing the light, a photometric unit arranged across the cell row and optically measuring the concentration change of the sample in the reaction cell, and the photometric data is collected based on the photometric data of the photometric unit. About the finished reaction cell Concentration calculating means for calculating the degree of pure water, pure water amount detecting means for detecting the amount of pure water in the tank, and pure water for judging whether or not the pure water runs out in the tank based on the detection signal of the pure water amount detecting means. A cutoff judging means, and a stop command means for stopping the cleaning by the cleaning means and stopping the dispensing of the sample dispensing means and the reagent dispensing means when the pure water running out judging means judges that the pure water is running out, Position storage means for storing the moving position of the reaction part when the pure water running-out judging means judges that the pure water is running out, and the position of the reaction part is stored in the position storing means after completion of the calculation of the concentration calculating means. An automatic chemical analyzer comprising: a position return command means for giving a command to the reaction part moving means so as to return to a stored position and stop. 2. A reaction section that holds a cell array composed of a plurality of reaction cells, and this reaction section is washed from a preset sample dispensing position through a reagent dispensing position or from a reagent dispensing position through the sample dispensing position. The reaction part moving means for moving in the direction of the position, the sample dispensing means for dispensing the sample to the reaction cell located at the sample dispensing position, and the reagent dispensing to the reaction cell located at the reagent dispensing position. The reagent dispensing means, a cleaning means for cleaning the reaction cell located at the cleaning position with at least pure water, and the pure water supplied from the pure water manufacturing apparatus connected to the external pure water manufacturing apparatus. A tank for storing the light, a photometric unit arranged across the cell row and optically measuring the concentration change of the sample in the reaction cell, and the photometric data is collected based on the photometric data of the photometric unit. About the finished reaction cell Concentration calculating means for calculating the degree of pure water, pure water amount detecting means for detecting the amount of pure water in the tank, and pure water for judging whether or not the pure water runs out in the tank based on the detection signal of the pure water amount detecting means. A cutoff judging means, and a stop command means for stopping the cleaning by the cleaning means and stopping the dispensing of the sample dispensing means and the reagent dispensing means when the pure water running out judging means judges that the pure water is running out, When the stop command means issues a stop command, the reagent indicating the reagent cannot be dispensed with the final reagent or the sample dispenser cannot dispense the sample. An automatic chemical analysis device, which is provided with a deionized water mark marking means. 3. The sample dispensing means and the reagent dispensing means,
Each has a syringe into which pure water is introduced from the tank,
The automatic chemical analysis device according to claim 1 or 2, which is a means for performing dispensing by the pressure accompanying the volume change of the syringe. 4. A pure water amount re-detecting means for re-detecting the amount of pure water in the tank while the concentration calculating means is performing concentration calculation after the stop instruction means has issued a stop instruction.
Based on the detection signal of the pure water amount re-detection means, the pure water running-out determination means for judging whether or not the pure water running out in the tank has been resolved, and the pure water running-out cancellation determination means are used to eliminate the pure water running out The resumption command means for releasing the suspension of the operations of the sample dispensing means, the reagent dispensing means, and the cleaning means and resuming the measurement when the determination is made.
Alternatively, the automatic chemical analysis device according to item 2. 5. A pure water depletion determining means at the start of measurement for determining whether or not the pure water depletion detecting means has detected depletion of pure water at the start of measurement, and the pure water depletion determining means at the start of measurement is pure water. The automatic chemical analyzer according to claim 1 or 2, further comprising: a priming water commanding means for causing pure water to be drawn into the pure water tank from the pure water producing apparatus when it is judged that the water has run out. 6. The automatic chemical analyzer according to claim 5, wherein the priming water commanding means is means provided with a mechanism for performing an extra priming operation for the volume of the flow path from the tank to the cleaning means. 7. The cleaning means is a means for cleaning using the pure water and a detergent, and the detergent supply means for supplying the detergent and the pure water running-out detecting means detect the running out of pure water. 3. The automatic chemical analyzer according to claim 1, further comprising a detergent supply stopping means for stopping the supply of the detergent by the detergent supplying means. 8. The concentration calculating means is a means including a mechanism for stopping the concentration calculation for the photometric data of the reaction cell marked by the pure water depletion mark giving means.
The automatic chemical analyzer described.