CN110139669A - T细胞疗法和btk抑制剂的组合疗法 - Google Patents

T细胞疗法和btk抑制剂的组合疗法 Download PDF

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Publication number
CN110139669A
CN110139669A CN201780082035.6A CN201780082035A CN110139669A CN 110139669 A CN110139669 A CN 110139669A CN 201780082035 A CN201780082035 A CN 201780082035A CN 110139669 A CN110139669 A CN 110139669A
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cell
inhibitor
subject
cancer
antigen
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Chinese (zh)
Inventor
M·朴茨
R·A·塞尔门
J·秦
O·巴图雷维奇
H·吉伦特沃特
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Juno Therapeutics Inc
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Juno Therapeutics Inc
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K40/00—Cellular immunotherapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2510/00—Genetically modified cells

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  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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CN201780082035.6A 2016-11-03 2017-11-03 T细胞疗法和btk抑制剂的组合疗法 Pending CN110139669A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662417312P 2016-11-03 2016-11-03
US62/417,312 2016-11-03
US201662429735P 2016-12-03 2016-12-03
US62/429,735 2016-12-03
US201762574706P 2017-10-19 2017-10-19
US62/574,706 2017-10-19
PCT/US2017/060060 WO2018085731A2 (en) 2016-11-03 2017-11-03 Combination therapy of a t cell therapy and a btk inhibitor

Publications (1)

Publication Number Publication Date
CN110139669A true CN110139669A (zh) 2019-08-16

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CN201780082035.6A Pending CN110139669A (zh) 2016-11-03 2017-11-03 T细胞疗法和btk抑制剂的组合疗法

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US (1) US20190298772A1 (enExample)
EP (1) EP3534938A2 (enExample)
JP (2) JP2019532997A (enExample)
CN (1) CN110139669A (enExample)
AU (1) AU2017355544A1 (enExample)
CA (1) CA3042049A1 (enExample)
MA (1) MA46783A (enExample)
MX (2) MX2019005029A (enExample)
WO (1) WO2018085731A2 (enExample)

Cited By (2)

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CN114206941A (zh) * 2019-07-26 2022-03-18 Abl生物公司 抗her2/抗4-1bb双特异性抗体及其用途
CN115485370A (zh) * 2020-03-20 2022-12-16 美国卫生和人力服务部 通过单细胞分析从肿瘤分离t细胞和t细胞受体以用于免疫疗法的方法

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DK3618842T3 (da) * 2017-05-01 2024-01-02 Juno Therapeutics Inc Kombination af en celleterapi og en immunomodulerende forbindelse
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WO2025137059A1 (en) * 2023-12-18 2025-06-26 Corvus Pharmaceuticals, Inc. Use of itk inhibitors and car t-cell therapy

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