CN110123758A - A kind of eye sprays agent, preparation method and application method with alleviation visual fatigue, improvement dry eye condition - Google Patents
A kind of eye sprays agent, preparation method and application method with alleviation visual fatigue, improvement dry eye condition Download PDFInfo
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- CN110123758A CN110123758A CN201910585206.8A CN201910585206A CN110123758A CN 110123758 A CN110123758 A CN 110123758A CN 201910585206 A CN201910585206 A CN 201910585206A CN 110123758 A CN110123758 A CN 110123758A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Abstract
The embodiment of the invention discloses a kind of with eye sprays agent, preparation method and the application method alleviating visual fatigue, improve dry eye condition, belongs to beauty consumptive material technical field, including A liquid, B liquid and C liquid；Wherein, A liquid includes soybean lecithin, ethyl alcohol, Phenoxyethanol, Retinol Palmitate, vitamin E and lutein；B liquid includes sodium chloride, Sodium Hyaluronate and calcium pantothenate；C liquid includes starch grafted acrylate and travoprost, appropriate purified water dissolved dilution.The problems such as when solving due to tear film rupture, moisture is evaporated from eyes, eyes drying redness.With quick, efficacy time is long, and preparation method is simple and efficient, the feature of usage mode simplicity, is convenient for industrialization production and popularization and application.
Description
Technical field
The present embodiments relate to beauty consumptive material technical fields, and in particular to one kind, which has, to be alleviated visual fatigue, improves dry eyes
Eye sprays agent, preparation method and the application method of symptom.
Background technique
Xerophthalmia refers to that tear matter caused by any reason or amount exception or dynamics are abnormal, causes under tear film stability
Drop, and with ophthalmic uncomfortable and (or) the general name of a variety of diseases of ocular lesion tissue feature.Also known as angle xerosis of conjunctiva.It is common
Symptom to include that eyes are dry and astringent, are easy tired, eye itch, has sticky foreign body sensation, pain burning heat sensation, secretion, fear of wind, photophobia, externally
Boundary's stimulation is very sensitive；Sometimes eyes are too dry, basic oligodacrya, stimulate reflexive lacrimal secretion instead, and cause usually to shed tears；
More severe case eyes can redness, hyperemia, keratinization, corneal epithelium broken skin and there is filiform to stick, with the passing of time this damage can then make
Angulation conjunctive disorder, and will affect eyesight.
In particular, with the emergence and use of smart screen equipment, increase with eye time and intensity, so that dry eyes
The crowd of disease is more and more.In the prior art, it can be added drop-wise in human eye, be improved by ancillary drugs such as artificial tears, eyedrops
The related symptoms of xerophthalmia.But it is intraocular due to needing to be added drop-wise to, the reaction of eyeball is easily caused, artificial tears or eyedrops are caused
Outflow, influences application effect.
Therefore, a kind of external preparation how is provided for eye periphery, is penetrated skin and is entered intraocular, establishes tears within the eye
Film is those skilled in the art's technical problem urgently to be resolved so as to improve the related symptoms of xerophthalmia.
Summary of the invention
For this purpose, the embodiment of the present invention provide it is a kind of with alleviate visual fatigue, improve dry eye condition eye sprays agent, preparation
Method and application method, when solving to rupture due to tear film in the prior art, moisture is evaporated from eyes, and eyes are dry to ask
Topic.
To achieve the goals above, the embodiment of the present invention provides the following technical solutions:
According to a first aspect of the embodiments of the present invention, have the embodiment of the invention provides one kind and alleviate visual fatigue, improvement
The eye sprays agent of dry eye condition, including A liquid, B liquid and C liquid；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
600-1000 parts of sodium chloride
5-25 parts of Sodium Hyaluronate
450-750 parts of calcium pantothenate
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
1-8 parts of starch grafted acrylate
1-5 parts of travoprost
Appropriate purified water dissolution.
Further, preferably eye sprays agent, including A liquid, B liquid and C liquid are provided；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
650-820 parts of sodium chloride
10-15 parts of Sodium Hyaluronate
500-650 parts of calcium pantothenate
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
2-5 parts of starch grafted acrylate
3-5 parts of travoprost
Appropriate purified water dissolution.
Further, preferably eye sprays agent, including A liquid, B liquid and C liquid are provided；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
720 parts of sodium chloride
15 parts of Sodium Hyaluronate
650 parts of calcium pantothenate
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
3 parts of starch grafted acrylate
4 parts of travoprost
Appropriate purified water dissolution.
According to a second aspect of the embodiments of the present invention, the embodiment of the invention provides a kind of preparation sides of eye sprays agent
Method is used to prepare eye sprays agent as described above comprising following steps:
1) soybean lecithin, ethyl alcohol, Phenoxyethanol, Retinol Palmitate, vitamin E and the leaf for weighing recipe quantity are yellow
The soybean lecithin dissolution of weighed recipe quantity is formed the first mixed liquor by element in ethanol；Under condition of heating and stirring, first
Retinol Palmitate, vitamin E, Phenoxyethanol and the lutein of recipe quantity are sequentially added in mixed liquor, form A liquid；
2) sodium chloride, Sodium Hyaluronate and calcium pantothenate for weighing recipe quantity, by the sodium chloride of weighed recipe quantity and transparent
Matter acid sodium, which is dissolved in appropriate purified water, forms the second mixed liquor, and under condition of heating and stirring, prescription is added in the second mixed liquor
The calcium pantothenate of amount forms B liquid；
3) starch grafted acrylate and travoprost for weighing recipe quantity, by the travoprost of weighed recipe quantity
It is dissolved in appropriate purified water and forms third mixed liquor, under microwave heating stirring condition, recipe quantity is added in third mixed liquor
Starch grafted acrylate, formed C liquid；
4) B liquid is gradually added drop-wise in A liquid to 35 DEG C, and under agitation and forms intermediate fluid, stir by adjustment A liquid temperature
Mixing revolving speed is 400rpm, mixing time 20min；
5) set-up procedure 4) obtained in intermediate fluid temperature to 40 DEG C, and under agitation, C liquid is gradually added drop-wise to
Between formed into liquid, speed of agitator 400rpm, mixing time 20min in liquid；
6) high-pressure homogeneous, circulation homogeneous 15-20 times will be carried out obtained in step 5) at liquid；
7) by liquid, water-bath 60min removes ethyl alcohol in 45 DEG C of water-baths obtained in step 6)；
8) it is filtered after being diluted at liquid by purified water obtained in step 7), and canned.
Further, the step 1) and 2) in, heating temperature be 30 DEG C, speed of agitator 250rpm, mixing time
10min。
Further, in the step 3), microwave heating power is 200W, and heating temperature is 30 DEG C, and speed of agitator is
250rpm, mixing time 10min.
Further, the step 6) mesohigh is homogeneous, and two-stage pressurizing is adjusted to 70Bar first, and homogeneous cycle-index is 10
Secondary, then level-one pressurization is adjusted to 700Bar, and homogeneous cycle-index is 10 times.
Further, in the step 8), passing through purified water dilution ratio at liquid is 20-26 times.
According to a third aspect of the embodiments of the present invention, the embodiment of the invention provides a kind of users of eye sprays agent
Method closes eyes using eye sprays agent as described above, for the first time towards under eye sprays two, after being spaced 15min, and second
It is secondary to be sprayed under two again.
Further, it is to improve using effect, after being sprayed two again for the second time down, non-woven fabrics is laid with outside eye, is laid with
Time is 20min.
The embodiment of the present invention has the advantages that
The liposome for including in spray provided by the invention is small liposome particles, is similar to natural tear film, when
Using it is spraying when, liposome is diffused into eyes at the edge of eyelid, blink and hangs on eyeball surface, helps to repair tear
The natural moisture barrier of eyes is restored in the gap of film, to reduce water loss, significantly improves the thickness and stabilization of lipid layer of lacrimal film
Property；A small amount of ethyl alcohol, the Sodium Hyaluronate contained in this spray, keeps the moisture retention of spraying ocular, and can promote to spray
Related Component penetrates into circumference of eyes skin in mist agent, further penetrates into eyes, and such penetration mode is able to maintain length
The diffusion of effect improves lasting medicine；Starch grafted acrylate has good Water-saving effect, can be by travoprost
Wrapped up, reduce intraocular pressure, promote spray in Related Component diffusion, starch grafted acrylate and in A liquid and B liquid
Related Component mixing after, further improve other compositions in the circumference of eyes retention time, reduce volatilization and scatter and disappear, improving makes
With effect, the calcium pantothenate contained can also help the skin moistened around eyelid and eyes.Spray of the invention facilitates long-acting
Improve the related symptoms of xerophthalmia, and forms and keep wet tears film in eyes.
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book is understood other advantages and efficacy of the present invention easily, it is clear that described embodiment is the present invention one
Section Example, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not doing
Every other embodiment obtained under the premise of creative work out, shall fall within the protection scope of the present invention.
To solve xerophthalmia caused by rupturing in the prior art due to tears film, the present invention provides a kind of eye sprays
Agent, production method and application method.Using spray of the invention, it is only necessary to it is spraying outside eye, do not have to makeup removing, it is hidden without removing
Shape glasses are penetrated by flowing into from eyelid with external, and can go directly eyes, realize good improvement.Following embodiments
The technical effect of the invention for explanation and illustration.
Embodiment 1
The embodiment of the invention provides a kind of with the eye sprays agent alleviated visual fatigue, improve dry eye condition, including A
Liquid, B liquid and C liquid；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
Sodium chloride 600g
Sodium Hyaluronate 15g
Calcium pantothenate 450g
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
Starch grafted acrylate 1g
Travoprost 1g
Appropriate purified water dissolution, and finally mix and diluted with purified water by A liquid, B liquid and C liquid, finally it is diluted to
100L。
Embodiment 2
The embodiment of the invention provides a kind of eye sprays agent, including A liquid, B liquid and C liquid；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
Sodium chloride 1000g
Sodium Hyaluronate 25g
Calcium pantothenate 750g
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
Starch grafted acrylate 8g
Travoprost 5g
Appropriate purified water dissolution, and finally mix and diluted with purified water by A liquid, B liquid and C liquid, finally it is diluted to
100L。
Embodiment 3
The embodiment of the invention provides a kind of eye sprays agent, including A liquid, B liquid and C liquid；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
Sodium chloride 720g
Sodium Hyaluronate 15g
Calcium pantothenate 650g
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
Starch grafted acrylate 3g
Travoprost 4g
Appropriate purified water dissolution, and finally mix and diluted with purified water by A liquid, B liquid and C liquid, finally it is diluted to
100L。
Embodiment 4
The embodiment of the invention provides a kind of eye sprays agent, including A liquid, B liquid and C liquid；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
Sodium chloride 820g
Sodium Hyaluronate 10g
Calcium pantothenate 500g
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
Starch grafted acrylate 5g
Travoprost 3g
Appropriate purified water dissolution, and finally mix and diluted with purified water by A liquid, B liquid and C liquid, finally it is diluted to
100L。
Embodiment 5
The embodiment of the invention provides a kind of eye sprays agent, including A liquid, B liquid and C liquid；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
Sodium chloride 650g
Sodium Hyaluronate 5g
Calcium pantothenate 450g
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
Starch grafted acrylate 2g
Travoprost 5g
Appropriate purified water dissolution, and finally mix and diluted with purified water by A liquid, B liquid and C liquid, finally it is diluted to
100L。
Embodiment 6
The embodiment of the invention provides a kind of eye sprays agent, including A liquid, B liquid and C liquid；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
Sodium chloride 700g
Sodium Hyaluronate 15g
Calcium pantothenate 600g
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
Starch grafted acrylate 2g
Travoprost 5g
Appropriate purified water dissolution, and finally mix and diluted with purified water by A liquid, B liquid and C liquid, finally it is diluted to
100L。
Comparative example 1
It chooses in embodiment 3 and is matched on the basis of the composition proportion of spray, but omit ingredient in C liquid.Specific ingredient is as follows:
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
Sodium chloride 720g
Sodium Hyaluronate 15g
Calcium pantothenate 650g
Appropriate purified water dissolution；Finally A liquid and B liquid mix and diluted with purified water, is finally diluted to 100L.
Comparative example 2
It chooses in embodiment 3 and is matched on the basis of the composition proportion of spray, but omit A liquid Lutein ingredient.Specifically at
Divide as follows:
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
Sodium chloride 720g
Sodium Hyaluronate 15g
Calcium pantothenate 650g
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
Starch grafted acrylate 3g
Travoprost 4g
Appropriate purified water dissolution, and finally mix and diluted with purified water by A liquid, B liquid and C liquid, finally it is diluted to
100L。
Production example
According to a second aspect of the embodiments of the present invention, the embodiment of the invention provides a kind of preparation sides of eye sprays agent
Method is used to prepare eye sprays agent as described above comprising following steps:
1) soybean lecithin, ethyl alcohol, Phenoxyethanol, Retinol Palmitate, vitamin E and the leaf for weighing recipe quantity are yellow
The soybean lecithin dissolution of weighed recipe quantity is formed the first mixed liquor by element in ethanol；Under condition of heating and stirring, heating temperature
Degree sequentially adds the vitamin A of recipe quantity for 30 DEG C, speed of agitator 250rpm, mixing time 10min in the first mixed liquor
Palmitate, vitamin E, Phenoxyethanol and lutein form A liquid；
2) sodium chloride, Sodium Hyaluronate and calcium pantothenate for weighing recipe quantity, by the sodium chloride of weighed recipe quantity and transparent
Matter acid sodium, which is dissolved in appropriate purified water, forms the second mixed liquor, and under condition of heating and stirring, heating temperature is 30 DEG C, speed of agitator
For 250rpm, mixing time 10min, the calcium pantothenate of recipe quantity is added in the second mixed liquor, forms B liquid；
3) starch grafted acrylate and travoprost for weighing recipe quantity, by the travoprost of weighed recipe quantity
It is dissolved in appropriate purified water and forms third mixed liquor, under microwave heating stirring condition, microwave heating power is 200W, heating temperature
Degree is 30 DEG C, speed of agitator 250rpm, mixing time 10min, and starch-grafted the third of recipe quantity is added in third mixed liquor
Olefin(e) acid salt forms C liquid；
4) B liquid is gradually added drop-wise in A liquid to 35 DEG C, and under agitation and forms intermediate fluid, stir by adjustment A liquid temperature
Mixing revolving speed is 400rpm, mixing time 20min；
5) set-up procedure 4) obtained in intermediate fluid temperature to 40 DEG C, and under agitation, C liquid is gradually added drop-wise to
Between formed into liquid, speed of agitator 400rpm, mixing time 20min in liquid；
6) will be high-pressure homogeneous at liquid progress obtained in step 5), two-stage pressurizing is adjusted to 70Bar, homogeneous cycle-index first
It is 10 times, then level-one pressurization is adjusted to 700Bar, and homogeneous cycle-index is 10 times；
7) by liquid, water-bath 60min removes ethyl alcohol in 45 DEG C of water-baths obtained in step 6)；
8) it is filtered after being diluted at liquid by purified water obtained in step 7), passes through purified water dilution ratio at liquid
It is 20-26 times, in such inventive embodiments, is diluted to 100L, and canned.
It should be noted that when making the spray in comparative example 1 and comparative example 2, it is only necessary to omit relevant ingredient
With production stage, other production stages are all the same.
By the spray that above-mentioned steps produce, the general light blue opalescence of product is placed and is generated without precipitating.When ophthalmic administration,
Substantially nonirritant, more former to grind fragrance thin.
Use embodiment
According to a third aspect of the embodiments of the present invention, the embodiment of the invention provides a kind of users of eye sprays agent
Method, selecting 88 has the related indication patient of xerophthalmia, is equally divided into 8 teams, respectively as follows using as embodiment 1,
The spray of embodiment 2 etc., and using effect is evaluated.Using eye sprays agent as described above, using spraying apparatus,
Eyes are closed, for the first time towards under eye sprays two, after being spaced 15min, are sprayed under two again for the second time.
In order to prevent in use, due to moisture evaporation and drug ingedient volatilization the problem of.Further, to mention
High using effect is laid with non-woven fabrics after being sprayed two again for the second time down outside eye, and the laying time is 20min.
The comparison such as the following table 1 of using effect in different time:
By the summary of above-mentioned using effect, illustrate that the spray prepared using the present invention can quickly have effect, and
And embodiment 1-6 has the maintenance effect up to 4 hours, substantially increases using effect compared with comparative example 1 and 2.The present invention
The liposome for including in the spray of offer is small liposome particles, is similar to natural tear film, when using spraying, rouge
Plastid is diffused into eyes at the edge of eyelid, blink and hangs on eyeball surface, facilitates the gap for repairing tear film, restores
The natural moisture barrier of eyes significantly improves the thickness and stability of lipid layer of lacrimal film to reduce water loss；In this spray
A small amount of ethyl alcohol, the Sodium Hyaluronate contained, keeps the moisture retention of spraying ocular, and can promote Related Component in spray
It penetrates into circumference of eyes skin, further penetrates into eyes, such penetration mode is able to maintain long-acting diffusion, improves medicine
Imitate persistence；Starch grafted acrylate has good Water-saving effect, can wrap up travoprost, reduces eye
Pressure, promotes the diffusion of Related Component in spray, and starch grafted acrylate is simultaneously mixed with the Related Component in A liquid and B liquid
Afterwards, other compositions are further improved in the circumference of eyes retention time, volatilization is reduced and scatters and disappears, improve using effect, contain
Calcium pantothenate can also help the skin moistened around eyelid and eyes.Spray of the invention facilitates long-acting improvement xerophthalmia
Related symptoms, and wet tears film is formed and kept in eyes.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention are fallen within the scope of the claimed invention.
Claims (10)
1. a kind of with the eye sprays agent alleviated visual fatigue, improve dry eye condition, which is characterized in that including A liquid, B liquid and C
Liquid；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
600-1000 parts of sodium chloride
5-25 parts of Sodium Hyaluronate
450-750 parts of calcium pantothenate
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
1-8 parts of starch grafted acrylate
1-5 parts of travoprost
Appropriate purified water dissolution.
2. eye sprays agent as described in claim 1, which is characterized in that including A liquid, B liquid and C liquid；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
650-820 parts of sodium chloride
10-15 parts of Sodium Hyaluronate
500-650 parts of calcium pantothenate
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
2-5 parts of starch grafted acrylate
3-5 parts of travoprost
Appropriate purified water dissolution.
3. eye sprays agent as claimed in claim 2, which is characterized in that including A liquid, B liquid and C liquid；Wherein,
The A liquid includes the raw material of following components by weight percent:
The B liquid includes the raw material of following components by weight percent:
720 parts of sodium chloride
15 parts of Sodium Hyaluronate
650 parts of calcium pantothenate
Appropriate purified water dissolution；
The C liquid includes the raw material of following components by weight percent:
3 parts of starch grafted acrylate
4 parts of travoprost
Appropriate purified water dissolution.
4. a kind of preparation method of eye sprays agent, is used to prepare eye sprays agent as claimed in any one of claims 1-3,
It is characterized in that, itself the following steps are included:
1) soybean lecithin, ethyl alcohol, Phenoxyethanol, Retinol Palmitate, vitamin E and the lutein of recipe quantity are weighed, it will
The soybean lecithin dissolution of weighed recipe quantity forms the first mixed liquor in ethanol；Under condition of heating and stirring, in the first mixing
Retinol Palmitate, vitamin E, Phenoxyethanol and the lutein of recipe quantity are sequentially added in liquid, form A liquid；
2) sodium chloride, Sodium Hyaluronate and calcium pantothenate for weighing recipe quantity, by the sodium chloride and hyaluronic acid of weighed recipe quantity
Sodium, which is dissolved in appropriate purified water, forms the second mixed liquor, and under condition of heating and stirring, recipe quantity is added in the second mixed liquor
Calcium pantothenate forms B liquid；
3) starch grafted acrylate and travoprost for weighing recipe quantity dissolve the travoprost of weighed recipe quantity
Third mixed liquor is formed in appropriate purified water, and under microwave heating stirring condition, the shallow lake of recipe quantity is added in third mixed liquor
Powder grafted propylene hydrochlorate forms C liquid；
4) B liquid is gradually added drop-wise in A liquid to 35 DEG C, and under agitation and forms intermediate fluid by adjustment A liquid temperature, and stirring turns
Speed is 400rpm, mixing time 20min；
5) set-up procedure 4) obtained in intermediate fluid temperature to 40 DEG C, and under agitation, C liquid is gradually added drop-wise to intermediate fluid
Middle formation is at liquid, speed of agitator 400rpm, mixing time 20min；
6) high-pressure homogeneous, circulation homogeneous 15-20 times will be carried out obtained in step 5) at liquid；
7) by liquid, water-bath 60min removes ethyl alcohol in 45 DEG C of water-baths obtained in step 6)；
8) it is filtered after being diluted at liquid by purified water obtained in step 7), and canned.
5. the preparation method of eye sprays agent as claimed in claim 4, which is characterized in that the step 1) and 2) in, heating
Temperature is 30 DEG C, speed of agitator 250rpm, mixing time 10min.
6. the preparation method of eye sprays agent as claimed in claim 4, which is characterized in that in the step 3), microwave heating
Power is 200W, and heating temperature is 30 DEG C, speed of agitator 250rpm, mixing time 10min.
7. the preparation method of eye sprays agent as claimed in claim 4, which is characterized in that the step 6) mesohigh is homogeneous,
Two-stage pressurizing is adjusted to 70Bar first, and homogeneous cycle-index is 10 times, and then level-one pressurization is adjusted to 700Bar, homogeneous cycle-index
It is 10 times.
8. the preparation method of eye sprays agent as claimed in claim 4, which is characterized in that in the step 8), pass through at liquid
Purified water dilution ratio is 20-26 times.
9. the application method of eye sprays agent, using eye sprays agent as claimed in any one of claims 1-3, feature exists
In closing eyes, for the first time towards under eye sprays two, after being spaced 15min, be sprayed under two again for the second time.
10. the application method of eye sprays agent as claimed in claim 9, which is characterized in that after under being sprayed two again for the second time,
Non-woven fabrics is laid with outside eye, the laying time is 20min.
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| CN201910585206.8A CN110123758B (en) | 2019-07-01 | 2019-07-01 | Eye spray with functions of relieving asthenopia and improving xerophthalmia symptoms, preparation method and use method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111671722A (en) * | 2020-07-30 | 2020-09-18 | 成都大学 | Eye drops and preparation method thereof |
| CN114469900A (en) * | 2022-02-21 | 2022-05-13 | 北京元莱健康管理有限公司 | Pharmaceutical composition for improving eye symptoms, preparation method and using method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581515A (en) * | 2016-12-09 | 2017-04-26 | 陈忠燕 | Spraying agent for relieving eye fatigue and preparing method thereof |
| CN106619976A (en) * | 2016-11-18 | 2017-05-10 | 广州宏韵医药科技股份有限公司 | External O/W type micro-emulsion eye spray and preparation method thereof |
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2019
- 2019-07-01 CN CN201910585206.8A patent/CN110123758B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619976A (en) * | 2016-11-18 | 2017-05-10 | 广州宏韵医药科技股份有限公司 | External O/W type micro-emulsion eye spray and preparation method thereof |
| CN106581515A (en) * | 2016-12-09 | 2017-04-26 | 陈忠燕 | Spraying agent for relieving eye fatigue and preparing method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111671722A (en) * | 2020-07-30 | 2020-09-18 | 成都大学 | Eye drops and preparation method thereof |
| CN114469900A (en) * | 2022-02-21 | 2022-05-13 | 北京元莱健康管理有限公司 | Pharmaceutical composition for improving eye symptoms, preparation method and using method |
| CN114469900B (en) * | 2022-02-21 | 2023-10-03 | 北京元莱健康管理有限公司 | Pharmaceutical composition for improving eye symptoms, preparation method and use method |
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| CN110123758B (en) | 2021-01-26 |
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Effective date of registration: 20210730 Address after: 430000 floor 5, building 4, No. 18, Jinfu Road, Hanyang District, Wuhan City, Hubei Province Patentee after: Yuanlai health products (Wuhan) Co.,Ltd. Address before: 611, block a, Tiancheng science and technology building, 2 Dewai Xinfeng street, Xicheng District, Beijing Patentee before: BEIJING YUANLAI HEALTH MANAGEMENT Co.,Ltd. |