CN110114346B - 用于制备r-6-羟基-8-[1-羟基-2-[2-(4-甲氧基苯基)-1，1-二甲基乙基氨基乙基]-2h-1，4-苯并噁嗪-3(4h)-酮盐酸盐的改进方法 - Google Patents

用于制备r-6-羟基-8-[1-羟基-2-[2-(4-甲氧基苯基)-1，1-二甲基乙基氨基乙基]-2h-1，4-苯并噁嗪-3(4h)-酮盐酸盐的改进方法 Download PDF

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Publication number
CN110114346B
CN110114346B CN201780078487.7A CN201780078487A CN110114346B CN 110114346 B CN110114346 B CN 110114346B CN 201780078487 A CN201780078487 A CN 201780078487A CN 110114346 B CN110114346 B CN 110114346B
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camphorsulfonate
acid
methoxyphenyl
compound
dimethyl
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Chinese (zh)
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CN110114346A (zh
Inventor
昂里克·卡德维拉乌瓦内哈
胡安·乌格特克洛泰
佩尔·达尔马塞斯巴尔琼
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Neuraxpharm Pharmaceuticals SL
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Laboratorios Lesvi SL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201780078487.7A 2016-12-20 2017-12-19 用于制备r-6-羟基-8-[1-羟基-2-[2-(4-甲氧基苯基)-1，1-二甲基乙基氨基乙基]-2h-1，4-苯并噁嗪-3(4h)-酮盐酸盐的改进方法 Active CN110114346B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16382628 2016-12-20
EP16382628.2 2016-12-20
EP17382449.1 2017-07-10
EP17382449 2017-07-10
PCT/EP2017/083444 WO2018114887A1 (en) 2016-12-20 2017-12-19 Improved process for the manufacture of r-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylaminoethyl]-2h-1,4-benzoxazin-3(4h)-one hydrochloride

Publications (2)

Publication Number Publication Date
CN110114346A CN110114346A (zh) 2019-08-09
CN110114346B true CN110114346B (zh) 2023-10-31

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CN201780078487.7A Active CN110114346B (zh) 2016-12-20 2017-12-19 用于制备r-6-羟基-8-[1-羟基-2-[2-(4-甲氧基苯基)-1，1-二甲基乙基氨基乙基]-2h-1，4-苯并噁嗪-3(4h)-酮盐酸盐的改进方法

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US (1) US10800748B2 (https=)
EP (1) EP3558954B1 (https=)
JP (1) JP7116060B2 (https=)
CN (1) CN110114346B (https=)
DK (1) DK3558954T3 (https=)
ES (1) ES2900283T3 (https=)
HR (1) HRP20211915T1 (https=)
PL (1) PL3558954T3 (https=)
WO (1) WO2018114887A1 (https=)

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CN108997248B (zh) * 2018-08-06 2023-08-01 上海方予健康医药科技有限公司 盐酸奥达特罗晶型b及其制备方法
CN108822054B (zh) * 2018-08-06 2021-06-22 上海方予健康医药科技有限公司 盐酸奥达特罗晶型c及其制备方法
CN109096218B (zh) * 2018-08-06 2020-10-27 上海方予健康医药科技有限公司 盐酸奥达特罗晶型a及其制备方法
CN114057590A (zh) * 2021-11-12 2022-02-18 安徽有吉医药科技有限公司 一种奥达特罗关键中间体的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101208316A (zh) * 2005-08-15 2008-06-25 贝林格尔·英格海姆国际有限公司 制备β-模拟物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10253282A1 (de) 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
AR065017A1 (es) 2007-01-25 2009-05-13 Boehringer Ingelheim Int Procedimiento para la preparacion de betamimeticos
US20100249550A1 (en) 2009-03-25 2010-09-30 Neilcor Puritan Bennett LLC Method And Apparatus For Optical Filtering Of A Broadband Emitter In A Medical Sensor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101208316A (zh) * 2005-08-15 2008-06-25 贝林格尔·英格海姆国际有限公司 制备β-模拟物的方法

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Publication number Publication date
CN110114346A (zh) 2019-08-09
WO2018114887A1 (en) 2018-06-28
ES2900283T3 (es) 2022-03-16
JP2020502077A (ja) 2020-01-23
HRP20211915T1 (hr) 2022-03-18
EP3558954B1 (en) 2021-11-03
JP7116060B2 (ja) 2022-08-09
US20200062723A1 (en) 2020-02-27
EP3558954A1 (en) 2019-10-30
US10800748B2 (en) 2020-10-13
DK3558954T3 (da) 2021-12-06
PL3558954T3 (pl) 2022-01-31

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