CN110101823A - A kind of Chinese medical extract that treating the proliferation of mammary gland and its extracting method and application - Google Patents
A kind of Chinese medical extract that treating the proliferation of mammary gland and its extracting method and application Download PDFInfo
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- CN110101823A CN110101823A CN201910529060.5A CN201910529060A CN110101823A CN 110101823 A CN110101823 A CN 110101823A CN 201910529060 A CN201910529060 A CN 201910529060A CN 110101823 A CN110101823 A CN 110101823A
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- 239000000284 extract Substances 0.000 title claims abstract description 161
- 210000005075 mammary gland Anatomy 0.000 title claims abstract description 45
- 230000035755 proliferation Effects 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 20
- 210000003038 endothelium Anatomy 0.000 claims abstract description 99
- 239000003814 drug Substances 0.000 claims abstract description 28
- 239000002994 raw material Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 90
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 84
- 235000019441 ethanol Nutrition 0.000 claims description 54
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 48
- 239000000047 product Substances 0.000 claims description 36
- 238000003756 stirring Methods 0.000 claims description 30
- 239000000706 filtrate Substances 0.000 claims description 26
- 238000002156 mixing Methods 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 21
- 238000000605 extraction Methods 0.000 claims description 20
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 18
- 239000012530 fluid Substances 0.000 claims description 18
- 230000007935 neutral effect Effects 0.000 claims description 18
- 235000011164 potassium chloride Nutrition 0.000 claims description 18
- 239000001103 potassium chloride Substances 0.000 claims description 18
- 238000000926 separation method Methods 0.000 claims description 18
- 238000005352 clarification Methods 0.000 claims description 14
- 239000012153 distilled water Substances 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 14
- 241001072909 Salvia Species 0.000 claims description 12
- 235000017276 Salvia Nutrition 0.000 claims description 12
- 238000009835 boiling Methods 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 12
- 238000012869 ethanol precipitation Methods 0.000 claims description 12
- 239000012259 ether extract Substances 0.000 claims description 12
- 239000012634 fragment Substances 0.000 claims description 12
- 238000000227 grinding Methods 0.000 claims description 12
- 235000021110 pickles Nutrition 0.000 claims description 12
- 238000004090 dissolution Methods 0.000 claims description 11
- 241000287828 Gallus gallus Species 0.000 claims description 9
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 8
- 239000010931 gold Substances 0.000 claims description 8
- 229910052737 gold Inorganic materials 0.000 claims description 8
- 241000304195 Salvia miltiorrhiza Species 0.000 claims description 6
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims description 6
- 230000018044 dehydration Effects 0.000 claims description 6
- 238000006297 dehydration reaction Methods 0.000 claims description 6
- 238000004108 freeze drying Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000012456 homogeneous solution Substances 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 238000010025 steaming Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 10
- 238000010521 absorption reaction Methods 0.000 abstract description 5
- 235000013305 food Nutrition 0.000 abstract description 5
- 230000006870 function Effects 0.000 abstract description 5
- 239000003053 toxin Substances 0.000 abstract description 5
- 231100000765 toxin Toxicity 0.000 abstract description 5
- 230000000968 intestinal effect Effects 0.000 abstract description 4
- 230000003907 kidney function Effects 0.000 abstract description 4
- 206010006256 Breast hyperplasia Diseases 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract description 3
- 239000008280 blood Substances 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 abstract description 3
- 201000006549 dyspepsia Diseases 0.000 abstract description 3
- 230000004089 microcirculation Effects 0.000 abstract description 3
- 239000013589 supplement Substances 0.000 abstract description 3
- 238000004821 distillation Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 206010013954 Dysphoria Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 230000005195 poor health Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010006298 Breast pain Diseases 0.000 description 1
- 241000202726 Bupleurum Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000006662 Mastodynia Diseases 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000008508 epithelial proliferation Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 244000005709 gut microbiome Species 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of Chinese medical extract for treating the proliferation of mammary gland and its extracting method and applications, the Chinese medical extract is mainly as made by the following raw material medicine: Radix Curcumae 45-55 parts by weight, Radix Angelicae Sinensis 40-50 parts by weight, radix bupleuri 20-30 parts by weight, Radix Salviae Miltiorrhizae 25-35 parts by weight, endothelium corneum gigeriae galli 10-12 parts by weight, thallus laminariae 12-16 parts by weight, dried orange peel 5-8 parts by weight, compared with the existing technology, structure of the invention is scientific and reasonable, it is safe and convenient to use, gained Chinese medical extract of the invention, can to human breast's hyperplasia position disappear newborn dissipating bind when, supplement blood of human body, activating microcirculation and removing stasis medicinal, alleviate the dyspepsia that human body occurs when taking the Chinese medical extract of the treatment proliferation of mammary gland, indirectly reduce influence of the Chinese medical extract to absorption of human body food, and it is able to maintain the newborn dissipating bind effect that preferably disappears , while will not kidney functions of expelling toxin to drug user and function of intestinal canal impact, and user takes drugs the recurrence probability of the rear proliferation of mammary gland and is able to maintain compared with low state.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, specially a kind of Chinese medical extract for treating the proliferation of mammary gland and its extraction
Methods and applications.
Background technique
Cyclomastopathy, neither tumour, is also not belonging to inflammation, in terms of histological appearance: being mammoplasia and move back
Row becomes, and closely related with endocrine dysfunction, this disease is apt to occur in middle-aged women, and teenager and postmenopausal women also have hair
Raw, 50%-70% has the different degrees of proliferation of mammary gland in current big city career woman, and cyclomastopathy often shows as breast pain
Pain and mammary gland touch tubercle, endanger and do not lie in disease itself, but psychological pressure, worry can do by myself and will not suffer from breast cancer
Or will become cancer later, it only it is noted that adjusting mentality, relieves stress, it is possible to gradually alleviate, if hyperplasia of mammary glands is with conduit
Epithelial proliferation, and severe abnormity is presented, it needs active treatment to inspect periodically, prevents trouble before it happens；
In the prior art, proliferation of mammary gland drug is primarily only to be treated for lesions position, and human body is easy after taking drugs
There is the case where medicine irritation because in poor health or individual physique is different, to generate certain side effect, influences drug
Absorption and curative effect.
Summary of the invention
The present invention provides technical solution, and it is main only can effectively to solve proliferation of mammary gland drug mentioned above in the background art
It is to be treated for lesions position, human body is easy medicine occur because in poor health or individual physique is different after taking drugs
The case where object stimulates, thus the problem of generating certain side effect, influencing the absorption and curative effect of drug.
To achieve the above object, the invention provides the following technical scheme: a kind of Chinese medical extract for treating the proliferation of mammary gland, is somebody's turn to do
Chinese medical extract is mainly as made by the following raw material medicine:
Radix Curcumae 45-55 parts by weight, Radix Angelicae Sinensis 40-50 parts by weight, radix bupleuri 20-30 parts by weight, Radix Salviae Miltiorrhizae 25-35 parts by weight, endothelium corneum gigeriae galli 10-
12 parts by weight, thallus laminariae 12-16 parts by weight, dried orange peel 5-8 parts by weight.
According to above-mentioned technical characteristic, the Chinese medical extract is mainly as made by the bulk pharmaceutical chemicals of following parts by weight:
50 parts by weight of Radix Curcumae, 45 parts by weight of Radix Angelicae Sinensis, 25 parts by weight of radix bupleuri, 30 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of endothelium corneum gigeriae galli, thallus laminariae 14
Parts by weight, 8 parts by weight of dried orange peel.
A kind of extracting method and application of Chinese medical extract that treating the proliferation of mammary gland, the Chinese medical extract is in the following way
It is prepared:
S1, the broken progress ethyl alcohol extraction respectively of Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product and moisture are extracted, filtrate is carried out dense
Contracting forms Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel extracts；
S2, after being sliced Radix Salviae Miltiorrhizae, room temperature moisture is added and stirs, under reduced pressure, is heated to boiling, extract and by depressurizing back
It receives, obtains Salvia root P.E after dry；
S3, endothelium corneum gigeriae galli is subjected to high-temperature baking, is then milled into powder, add water and stir to form homogeneous solution, filtered, take after decoction
Filtered fluid carries out centrifugal clarification out, takes clarified solution, and ether is added and stands, increases temperature after separation, the powder left is chicken
Interior gold extract；
S4, heated at constant temperature will be carried out in thallus laminariae addition steamer, neutral sylvite is added after cooling and pickles, centrifuge, which is dehydrated, to be contained
The liquid of Thallus Laminariae (Thallus Eckloniae) extract, then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract；
S5, obtained Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri, dried orange peel, Radix Salviae Miltiorrhizae, endothelium corneum gigeriae galli and Thallus Laminariae (Thallus Eckloniae) extract are sufficiently mixed, are controlled
Treat the Chinese medical extract of the proliferation of mammary gland.
According to above-mentioned technical characteristic, the step S1 is specifically divided into following steps:
A, alcohol extracting: being broken into tiny fragment for Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product, at room temperature, ethyl alcohol is added
Middle extraction, is filtered solution, and filtrate is concentrated, and obtains alcohol extracting extract；
B, water extracts: the filter residue of filtering being added in distilled water, the filtrate filtered then is concentrated, obtains by heating extraction
Water mentions extract.
According to above-mentioned technical characteristic, step a in the step S1 specifically, by be broken into tiny fragment Radix Curcumae,
Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product are separately added into the ethyl alcohol that concentration is 70%, stir within 20 minutes, and it is small to extract 2 using ethyl alcohol
When, it is then filtered, takes out the solid filter residue that filtering obtains, filtrate is concentrated, it is dry under conditions of 50 DEG C
20min obtains the alcohol extracting extract of Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product, Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and the dried orange peel dry product of addition
Mass ratio with ethyl alcohol is 1:40.
According to above-mentioned technical characteristic, the step b in the step S1 by the filter residue obtained is filtered in alcohol extracting specifically, be added
In distilled water, the weight ratio of filter residue and distilled water is 1:12, is heated to 55 DEG C, is extracted with water 2.5 hours, is then filtered,
Filtrate is concentrated, dry 25min, the water for obtaining Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product propose extraction under conditions of 50 DEG C
Object.
According to above-mentioned technical characteristic, in the step S2, fresh salvia miltiorrhiza is chosen, after Radix Salviae Miltiorrhizae is sliced, room temperature is added
Moisture stirring, the single-sheet thickness of Radix Salviae Miltiorrhizae slice are 1mm, at reduced pressure conditions, are heated to 70 DEG C of water temperature boilings, extract and by subtracting
Receipts are pushed back, after freeze-drying water removal, obtain Salvia root P.E.
According to above-mentioned technical characteristic, the step S3 is specifically divided into following steps:
A: carrying out high-temperature baking for endothelium corneum gigeriae galli, until endothelium corneum gigeriae galli surface discolouration, then grinds the endothelium corneum gigeriae galli after baking, and
After grinding, the endothelium corneum gigeriae galli after grinding is added in clear water and is stirred until homogeneous；
B: will stir evenly endothelium corneum gigeriae galli solution and carry out decoction dissolution, become mixing decoction liquor, is filtered, takes to mixing decoction liquor
Filtered fluid is added in centrifuge out, carries out centrifugal clarification, takes clarified solution；
C: clarified solution is cooled down, and ether is added and stands, and separation removal upper layer ether extracts mixed liquor, increases temperature for container
The remaining powder in bottom takes out, as Endothelium Corneum Gigeriae Galli extract.
According to above-mentioned technical characteristic, the step S3 is specifically, carry out 120 DEG C of high-temperature bakings, holding temperature for endothelium corneum gigeriae galli
Then the endothelium corneum gigeriae galli after baking is ground to endothelium corneum gigeriae galli surface discolouration within baking 8 minutes, is added in clear water and is stirred until homogeneous,
The clear water quality of addition and the ratio of endothelium corneum gigeriae galli quality are 4:1, and mixed liquor is then increased to 100 DEG C and is decocted, is made in chicken
The dissolution of golden mixed liquor becomes mixing decoction liquor, is filtered to mixing decoction liquor, takes out filtered fluid and is added in centrifuge, carry out from
Heart clarification, takes clarified solution, and clarified solution temperature is reduced to 18 DEG C, is added ether, and the volume ratio of ether and clarified solution is 3:1, quiet
It sets 20 minutes, separation removal upper layer ether extracts mixed liquor, increases temperature and takes out the remaining powder of container bottom, as chicken
Interior gold extract.
According to above-mentioned technical characteristic, the step S4 steams 65 seconds specifically, thallus laminariae is added in steamer, the steam temperature of steamer
Degree is maintained at 85 DEG C, and neutral sylvite is added and pickles, the weight ratio of neutral sylvite and thallus laminariae is to room temperature after natural cooling after taking-up
2:5, centrifuge dehydration obtain the liquid containing Thallus Laminariae (Thallus Eckloniae) extract, and then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract.
Compared with prior art, beneficial effects of the present invention: structure of the invention is scientific and reasonable, safe and convenient to use:
The present invention chooses 50 parts by weight of Radix Curcumae, 45 parts by weight of Radix Angelicae Sinensis, radix bupleuri when extracting the Chinese medical extract of the treatment proliferation of mammary gland
25 parts by weight, 30 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of endothelium corneum gigeriae galli, 14 parts by weight of thallus laminariae, the raw medicinal material of 8 parts by weight of dried orange peel can be protected
Hold the newborn dissipating bind effect that preferably disappears, at the same will not kidney functions of expelling toxin to drug user and function of intestinal canal impact, and make
The recurrence probability that user takes drugs the rear proliferation of mammary gland is able to maintain compared with low state, extracts the dried orange peel material that parts by weight are 8, can have
Effect alleviates other Chinese medical extracts to the irritation of human body stomach, extracts the Radix Angelicae Sinensis that parts by weight are 45 and the pellet that parts by weight are 30
Ginseng, can to human breast's hyperplasia position disappear newborn dissipating bind when, supplement blood of human body, activating microcirculation and removing stasis medicinal, and alleviate human body go out
The case where existing hot numbness pain and dysphoria and insomnia, extracts the endothelium corneum gigeriae galli of 12 parts by weight, can be relieved human body and is taking treatment mammary gland increasing
The dyspepsia occurred when raw Chinese medical extract indirectly reduces influence of the Chinese medical extract to absorption of human body food, human body
It is not in because of the few food generated, indigestible situation of taking medicine.
Detailed description of the invention
Attached drawing is used to provide further understanding of the present invention, and constitutes part of specification, with reality of the invention
It applies example to be used to explain the present invention together, not be construed as limiting the invention.
In the accompanying drawings:
Fig. 1 is extracting method step schematic diagram of the invention；
Fig. 2 is 4 extracting method step schematic diagram of the embodiment of the present invention.
Specific embodiment
Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings, it should be understood that preferred reality described herein
Apply example only for the purpose of illustrating and explaining the present invention and is not intended to limit the present invention.
Embodiment 1: as shown in Figure 1, the present invention provides technical solution, a kind of Chinese medical extract for treating the proliferation of mammary gland should
Chinese medical extract is mainly as made by the following raw material medicine:
Radix Curcumae 45-55 parts by weight, Radix Angelicae Sinensis 40-50 parts by weight, radix bupleuri 20-30 parts by weight, Radix Salviae Miltiorrhizae 25-35 parts by weight, endothelium corneum gigeriae galli 10-
12 parts by weight, thallus laminariae 12-16 parts by weight, dried orange peel 5-8 parts by weight.
According to above-mentioned technical characteristic, the Chinese medical extract is mainly as made by the bulk pharmaceutical chemicals of following parts by weight:
50 parts by weight of Radix Curcumae, 45 parts by weight of Radix Angelicae Sinensis, 25 parts by weight of radix bupleuri, 30 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of endothelium corneum gigeriae galli, thallus laminariae 14
Parts by weight, 8 parts by weight of dried orange peel.
A kind of extracting method and application of Chinese medical extract that treating the proliferation of mammary gland, the Chinese medical extract is in the following way
It is prepared:
S1, the broken progress ethyl alcohol extraction respectively of Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product and moisture are extracted, filtrate is carried out dense
Contracting forms Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel extracts；
S2, after being sliced Radix Salviae Miltiorrhizae, room temperature moisture is added and stirs, under reduced pressure, is heated to boiling, extract and by depressurizing back
It receives, obtains Salvia root P.E after dry；
S3, endothelium corneum gigeriae galli is subjected to high-temperature baking, is then milled into powder, add water and stir to form homogeneous solution, filtered, take after decoction
Filtered fluid carries out centrifugal clarification out, takes clarified solution, and ether is added and stands, increases temperature after separation, the powder left is chicken
Interior gold extract；
S4, heated at constant temperature will be carried out in thallus laminariae addition steamer, neutral sylvite is added after cooling and pickles, centrifuge, which is dehydrated, to be contained
The liquid of Thallus Laminariae (Thallus Eckloniae) extract, then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract；
S5, obtained Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri, dried orange peel, Radix Salviae Miltiorrhizae, endothelium corneum gigeriae galli and Thallus Laminariae (Thallus Eckloniae) extract are sufficiently mixed, are controlled
Treat the Chinese medical extract of the proliferation of mammary gland.
According to above-mentioned technical characteristic, step S1 is specifically divided into following steps:
A, alcohol extracting: being broken into tiny fragment for Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product, at room temperature, ethyl alcohol is added
Middle extraction, is filtered solution, and filtrate is concentrated, and obtains alcohol extracting extract；
B, water extracts: the filter residue of filtering being added in distilled water, the filtrate filtered then is concentrated, obtains by heating extraction
Water mentions extract.
According to above-mentioned technical characteristic, step a in step S1 specifically, will be broken into the Radix Curcumae of tiny fragment, Radix Angelicae Sinensis,
Radix bupleuri and dried orange peel dry product are separately added into the ethyl alcohol that concentration is 70%, stir within 20 minutes, are extracted 2 hours using ethyl alcohol, with
After be filtered, take out the solid filter residue that obtains of filtering, filtrate be concentrated, dry 20min, obtains under conditions of 50 DEG C
Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product alcohol extracting extract, the Radix Curcumae of addition, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product and ethyl alcohol matter
Amount is than being 1:40.
According to above-mentioned technical characteristic, the step b in step S1 is specifically, be added distillation for the filter residue obtained is filtered in alcohol extracting
In water, the weight ratio of filter residue and distilled water is 1:12, is heated to 55 DEG C, is extracted with water 2.5 hours, is then filtered, will filter
Liquid is concentrated, and dry 25min, the water for obtaining Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product mention extract under conditions of 50 DEG C.
According to above-mentioned technical characteristic, in step S2, fresh salvia miltiorrhiza is chosen, after Radix Salviae Miltiorrhizae is sliced, room temperature moisture is added
Stirring, the single-sheet thickness of Radix Salviae Miltiorrhizae slice are 1mm, at reduced pressure conditions, are heated to 70 DEG C of water temperature boilings, extract and by depressurizing back
It receives, after freeze-drying water removal, obtains Salvia root P.E.
According to above-mentioned technical characteristic, step S3 is specifically divided into following steps:
A: carrying out high-temperature baking for endothelium corneum gigeriae galli, until endothelium corneum gigeriae galli surface discolouration, then grinds the endothelium corneum gigeriae galli after baking, and
After grinding, the endothelium corneum gigeriae galli after grinding is added in clear water and is stirred until homogeneous；
B: will stir evenly endothelium corneum gigeriae galli solution and carry out decoction dissolution, become mixing decoction liquor, is filtered, takes to mixing decoction liquor
Filtered fluid is added in centrifuge out, carries out centrifugal clarification, takes clarified solution；
C: clarified solution is cooled down, and ether is added and stands, and separation removal upper layer ether extracts mixed liquor, increases temperature for container
The remaining powder in bottom takes out, as Endothelium Corneum Gigeriae Galli extract.
According to above-mentioned technical characteristic, step S3 is specifically, carry out 120 DEG C of high-temperature bakings, holding temperature baking 8 for endothelium corneum gigeriae galli
Minute to endothelium corneum gigeriae galli surface discolouration, then the endothelium corneum gigeriae galli after baking is ground, is added in clear water and is stirred until homogeneous, addition
The ratio of clear water quality and endothelium corneum gigeriae galli quality is 4:1, and mixed liquor is then increased to 100 DEG C and is decocted, endothelium corneum gigeriae galli is mixed
Liquid dissolution becomes mixing decoction liquor, is filtered to mixing decoction liquor, takes out filtered fluid and is added in centrifuge, be centrifuged clear
Clearly, clarified solution is taken, clarified solution temperature is reduced to 18 DEG C, is added ether, the volume ratio of ether and clarified solution is 3:1, stands 20
Minute, separation removal upper layer ether extracts mixed liquor, increases temperature and takes out the remaining powder of container bottom, as endothelium corneum gigeriae galli
Extract.
According to above-mentioned technical characteristic, step S4 steams 65 seconds specifically, thallus laminariae is added in steamer, and the vapor (steam) temperature of steamer is protected
It holds at 85 DEG C, neutral sylvite is added and pickles to room temperature after natural cooling after taking-up, the weight ratio of neutral sylvite and thallus laminariae is 2:5,
Centrifuge dehydration obtains the liquid containing Thallus Laminariae (Thallus Eckloniae) extract, and then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract.
Embodiment 2: as shown in Figure 1, the present invention provides technical solution, a kind of Chinese medical extract for treating the proliferation of mammary gland should
Chinese medical extract is mainly as made by the following raw material medicine:
Radix Curcumae 45-55 parts by weight, Radix Angelicae Sinensis 40-50 parts by weight, radix bupleuri 20-30 parts by weight, Radix Salviae Miltiorrhizae 25-35 parts by weight, endothelium corneum gigeriae galli 10-
12 parts by weight, thallus laminariae 12-16 parts by weight, dried orange peel 5-8 parts by weight.
According to above-mentioned technical characteristic, the Chinese medical extract is mainly as made by the bulk pharmaceutical chemicals of following parts by weight:
48 parts by weight of Radix Curcumae, 47 parts by weight of Radix Angelicae Sinensis, 23 parts by weight of radix bupleuri, 32 parts by weight of Radix Salviae Miltiorrhizae, 11 parts by weight of endothelium corneum gigeriae galli, thallus laminariae 16
Parts by weight, 7 parts by weight of dried orange peel.
A kind of extracting method and application of Chinese medical extract that treating the proliferation of mammary gland, the Chinese medical extract is in the following way
It is prepared:
S1, the broken progress ethyl alcohol extraction respectively of Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product and moisture are extracted, filtrate is carried out dense
Contracting forms Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel extracts；
S2, after being sliced Radix Salviae Miltiorrhizae, room temperature moisture is added and stirs, under reduced pressure, is heated to boiling, extract and by depressurizing back
It receives, obtains Salvia root P.E after dry；
S3, endothelium corneum gigeriae galli is subjected to high-temperature baking, is then milled into powder, add water and stir to form homogeneous solution, filtered, take after decoction
Filtered fluid carries out centrifugal clarification out, takes clarified solution, and ether is added and stands, increases temperature after separation, the powder left is chicken
Interior gold extract；
S4, heated at constant temperature will be carried out in thallus laminariae addition steamer, neutral sylvite is added after cooling and pickles, centrifuge, which is dehydrated, to be contained
The liquid of Thallus Laminariae (Thallus Eckloniae) extract, then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract；
S5, obtained Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri, dried orange peel, Radix Salviae Miltiorrhizae, endothelium corneum gigeriae galli and Thallus Laminariae (Thallus Eckloniae) extract are sufficiently mixed, are controlled
Treat the Chinese medical extract of the proliferation of mammary gland.
According to above-mentioned technical characteristic, step S1 is specifically divided into following steps:
A, alcohol extracting: being broken into tiny fragment for Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product, at room temperature, ethyl alcohol is added
Middle extraction, is filtered solution, and filtrate is concentrated, and obtains alcohol extracting extract；
B, water extracts: the filter residue of filtering being added in distilled water, the filtrate filtered then is concentrated, obtains by heating extraction
Water mentions extract.
According to above-mentioned technical characteristic, step a in step S1 specifically, will be broken into the Radix Curcumae of tiny fragment, Radix Angelicae Sinensis,
Radix bupleuri and dried orange peel dry product are separately added into the ethyl alcohol that concentration is 70%, stir within 20 minutes, are extracted 2 hours using ethyl alcohol, with
After be filtered, take out the solid filter residue that obtains of filtering, filtrate be concentrated, dry 20min, obtains under conditions of 50 DEG C
Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product alcohol extracting extract, the Radix Curcumae of addition, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product and ethyl alcohol matter
Amount is than being 1:40.
According to above-mentioned technical characteristic, the step b in step S1 is specifically, be added distillation for the filter residue obtained is filtered in alcohol extracting
In water, the weight ratio of filter residue and distilled water is 1:12, is heated to 55 DEG C, is extracted with water 2.5 hours, is then filtered, will filter
Liquid is concentrated, and dry 25min, the water for obtaining Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product mention extract under conditions of 50 DEG C.
According to above-mentioned technical characteristic, in step S2, fresh salvia miltiorrhiza is chosen, after Radix Salviae Miltiorrhizae is sliced, room temperature moisture is added
Stirring, the single-sheet thickness of Radix Salviae Miltiorrhizae slice are 1mm, at reduced pressure conditions, are heated to 70 DEG C of water temperature boilings, extract and by depressurizing back
It receives, after freeze-drying water removal, obtains Salvia root P.E.
According to above-mentioned technical characteristic, step S3 is specifically divided into following steps:
A: carrying out high-temperature baking for endothelium corneum gigeriae galli, until endothelium corneum gigeriae galli surface discolouration, then grinds the endothelium corneum gigeriae galli after baking, and
After grinding, the endothelium corneum gigeriae galli after grinding is added in clear water and is stirred until homogeneous；
B: will stir evenly endothelium corneum gigeriae galli solution and carry out decoction dissolution, become mixing decoction liquor, is filtered, takes to mixing decoction liquor
Filtered fluid is added in centrifuge out, carries out centrifugal clarification, takes clarified solution；
C: clarified solution is cooled down, and ether is added and stands, and separation removal upper layer ether extracts mixed liquor, increases temperature for container
The remaining powder in bottom takes out, as Endothelium Corneum Gigeriae Galli extract.
According to above-mentioned technical characteristic, step S3 is specifically, carry out 120 DEG C of high-temperature bakings, holding temperature baking 8 for endothelium corneum gigeriae galli
Minute to endothelium corneum gigeriae galli surface discolouration, then the endothelium corneum gigeriae galli after baking is ground, is added in clear water and is stirred until homogeneous, addition
The ratio of clear water quality and endothelium corneum gigeriae galli quality is 4:1, and mixed liquor is then increased to 100 DEG C and is decocted, endothelium corneum gigeriae galli is mixed
Liquid dissolution becomes mixing decoction liquor, is filtered to mixing decoction liquor, takes out filtered fluid and is added in centrifuge, be centrifuged clear
Clearly, clarified solution is taken, clarified solution temperature is reduced to 18 DEG C, is added ether, the volume ratio of ether and clarified solution is 3:1, stands 20
Minute, separation removal upper layer ether extracts mixed liquor, increases temperature and takes out the remaining powder of container bottom, as endothelium corneum gigeriae galli
Extract.
According to above-mentioned technical characteristic, step S4 steams 65 seconds specifically, thallus laminariae is added in steamer, and the vapor (steam) temperature of steamer is protected
It holds at 85 DEG C, neutral sylvite is added and pickles to room temperature after natural cooling after taking-up, the weight ratio of neutral sylvite and thallus laminariae is 2:5,
Centrifuge dehydration obtains the liquid containing Thallus Laminariae (Thallus Eckloniae) extract, and then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract.
Embodiment 3: as shown in Figure 1, the present invention provides technical solution, a kind of Chinese medical extract for treating the proliferation of mammary gland should
Chinese medical extract is mainly as made by the following raw material medicine:
Radix Curcumae 45-55 parts by weight, Radix Angelicae Sinensis 40-50 parts by weight, radix bupleuri 20-30 parts by weight, Radix Salviae Miltiorrhizae 25-35 parts by weight, endothelium corneum gigeriae galli 10-
12 parts by weight, thallus laminariae 12-16 parts by weight, dried orange peel 5-8 parts by weight.
According to above-mentioned technical characteristic, the Chinese medical extract is mainly as made by the bulk pharmaceutical chemicals of following parts by weight:
52 parts by weight of Radix Curcumae, 43 parts by weight of Radix Angelicae Sinensis, 28 parts by weight of radix bupleuri, 27 parts by weight of Radix Salviae Miltiorrhizae, 10 parts by weight of endothelium corneum gigeriae galli, thallus laminariae 16
Parts by weight, 8 parts by weight of dried orange peel.
A kind of extracting method and application of Chinese medical extract that treating the proliferation of mammary gland, the Chinese medical extract is in the following way
It is prepared:
S1, the broken progress ethyl alcohol extraction respectively of Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product and moisture are extracted, filtrate is carried out dense
Contracting forms Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel extracts；
S2, after being sliced Radix Salviae Miltiorrhizae, room temperature moisture is added and stirs, under reduced pressure, is heated to boiling, extract and by depressurizing back
It receives, obtains Salvia root P.E after dry；
S3, endothelium corneum gigeriae galli is subjected to high-temperature baking, is then milled into powder, add water and stir to form homogeneous solution, filtered, take after decoction
Filtered fluid carries out centrifugal clarification out, takes clarified solution, and ether is added and stands, increases temperature after separation, the powder left is chicken
Interior gold extract；
S4, heated at constant temperature will be carried out in thallus laminariae addition steamer, neutral sylvite is added after cooling and pickles, centrifuge, which is dehydrated, to be contained
The liquid of Thallus Laminariae (Thallus Eckloniae) extract, then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract；
S5, obtained Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri, dried orange peel, Radix Salviae Miltiorrhizae, endothelium corneum gigeriae galli and Thallus Laminariae (Thallus Eckloniae) extract are sufficiently mixed, are controlled
Treat the Chinese medical extract of the proliferation of mammary gland.
According to above-mentioned technical characteristic, step S1 is specifically divided into following steps:
A, alcohol extracting: being broken into tiny fragment for Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product, at room temperature, ethyl alcohol is added
Middle extraction, is filtered solution, and filtrate is concentrated, and obtains alcohol extracting extract；
B, water extracts: the filter residue of filtering being added in distilled water, the filtrate filtered then is concentrated, obtains by heating extraction
Water mentions extract.
According to above-mentioned technical characteristic, step a in step S1 specifically, will be broken into the Radix Curcumae of tiny fragment, Radix Angelicae Sinensis,
Radix bupleuri and dried orange peel dry product are separately added into the ethyl alcohol that concentration is 70%, stir within 20 minutes, are extracted 2 hours using ethyl alcohol, with
After be filtered, take out the solid filter residue that obtains of filtering, filtrate be concentrated, dry 20min, obtains under conditions of 50 DEG C
Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product alcohol extracting extract, the Radix Curcumae of addition, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product and ethyl alcohol matter
Amount is than being 1:40.
According to above-mentioned technical characteristic, the step b in step S1 is specifically, be added distillation for the filter residue obtained is filtered in alcohol extracting
In water, the weight ratio of filter residue and distilled water is 1:12, is heated to 55 DEG C, is extracted with water 2.5 hours, is then filtered, will filter
Liquid is concentrated, and dry 25min, the water for obtaining Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product mention extract under conditions of 50 DEG C.
According to above-mentioned technical characteristic, in step S2, fresh salvia miltiorrhiza is chosen, after Radix Salviae Miltiorrhizae is sliced, room temperature moisture is added
Stirring, the single-sheet thickness of Radix Salviae Miltiorrhizae slice are 1mm, at reduced pressure conditions, are heated to 70 DEG C of water temperature boilings, extract and by depressurizing back
It receives, after freeze-drying water removal, obtains Salvia root P.E.
According to above-mentioned technical characteristic, step S3 is specifically divided into following steps:
A: carrying out high-temperature baking for endothelium corneum gigeriae galli, until endothelium corneum gigeriae galli surface discolouration, then grinds the endothelium corneum gigeriae galli after baking, and
After grinding, the endothelium corneum gigeriae galli after grinding is added in clear water and is stirred until homogeneous；
B: will stir evenly endothelium corneum gigeriae galli solution and carry out decoction dissolution, become mixing decoction liquor, is filtered, takes to mixing decoction liquor
Filtered fluid is added in centrifuge out, carries out centrifugal clarification, takes clarified solution；
C: clarified solution is cooled down, and ether is added and stands, and separation removal upper layer ether extracts mixed liquor, increases temperature for container
The remaining powder in bottom takes out, as Endothelium Corneum Gigeriae Galli extract.
According to above-mentioned technical characteristic, step S3 is specifically, carry out 120 DEG C of high-temperature bakings, holding temperature baking 8 for endothelium corneum gigeriae galli
Minute to endothelium corneum gigeriae galli surface discolouration, then the endothelium corneum gigeriae galli after baking is ground, is added in clear water and is stirred until homogeneous, addition
The ratio of clear water quality and endothelium corneum gigeriae galli quality is 4:1, and mixed liquor is then increased to 100 DEG C and is decocted, endothelium corneum gigeriae galli is mixed
Liquid dissolution becomes mixing decoction liquor, is filtered to mixing decoction liquor, takes out filtered fluid and is added in centrifuge, be centrifuged clear
Clearly, clarified solution is taken, clarified solution temperature is reduced to 18 DEG C, is added ether, the volume ratio of ether and clarified solution is 3:1, stands 20
Minute, separation removal upper layer ether extracts mixed liquor, increases temperature and takes out the remaining powder of container bottom, as endothelium corneum gigeriae galli
Extract.
According to above-mentioned technical characteristic, step S4 steams 65 seconds specifically, thallus laminariae is added in steamer, and the vapor (steam) temperature of steamer is protected
It holds at 85 DEG C, neutral sylvite is added and pickles to room temperature after natural cooling after taking-up, the weight ratio of neutral sylvite and thallus laminariae is 2:5,
Centrifuge dehydration obtains the liquid containing Thallus Laminariae (Thallus Eckloniae) extract, and then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract.
Embodiment 4: as shown in Fig. 2, the present invention provides technical solution, a kind of Chinese medical extract for treating the proliferation of mammary gland should
Chinese medical extract is mainly as made by the following raw material medicine:
Radix Curcumae 45-55 parts by weight, Radix Angelicae Sinensis 40-50 parts by weight, radix bupleuri 20-30 parts by weight, Radix Salviae Miltiorrhizae 25-35 parts by weight, endothelium corneum gigeriae galli 10-
12 parts by weight, thallus laminariae 12-16 parts by weight.
According to above-mentioned technical characteristic, the Chinese medical extract is mainly as made by the bulk pharmaceutical chemicals of following parts by weight:
51 parts by weight of Radix Curcumae, 46 parts by weight of Radix Angelicae Sinensis, 22 parts by weight of radix bupleuri, 38 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of endothelium corneum gigeriae galli, thallus laminariae 15
Parts by weight.
A kind of extracting method and application of Chinese medical extract that treating the proliferation of mammary gland, the Chinese medical extract is in the following way
It is prepared:
S1, the broken progress ethyl alcohol extraction respectively of Radix Curcumae, Radix Angelicae Sinensis and radix bupleuri dry product and moisture are extracted, filtrate is subjected to concentration formation
Radix Curcumae, Radix Angelicae Sinensis and bupleurum extract；
S2, after being sliced Radix Salviae Miltiorrhizae, room temperature moisture is added and stirs, under reduced pressure, is heated to boiling, extract and by depressurizing back
It receives, obtains Salvia root P.E after dry；
S3, endothelium corneum gigeriae galli is subjected to high-temperature baking, is then milled into powder, add water and stir to form homogeneous solution, filtered, take after decoction
Filtered fluid carries out centrifugal clarification out, takes clarified solution, and ether is added and stands, increases temperature after separation, the powder left is chicken
Interior gold extract；
S4, heated at constant temperature will be carried out in thallus laminariae addition steamer, neutral sylvite is added after cooling and pickles, centrifuge, which is dehydrated, to be contained
The liquid of Thallus Laminariae (Thallus Eckloniae) extract, then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract；
S5, obtained Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri, dried orange peel, Radix Salviae Miltiorrhizae, endothelium corneum gigeriae galli and Thallus Laminariae (Thallus Eckloniae) extract are sufficiently mixed, are controlled
Treat the Chinese medical extract of the proliferation of mammary gland.
According to above-mentioned technical characteristic, step S1 is specifically divided into following steps:
A, alcohol extracting: being broken into tiny fragment for Radix Curcumae, Radix Angelicae Sinensis and radix bupleuri dry product, at room temperature, is added in ethyl alcohol and mentions
It takes, solution is filtered, filtrate is concentrated, obtain alcohol extracting extract；
B, water extracts: the filter residue of filtering being added in distilled water, the filtrate filtered then is concentrated, obtains by heating extraction
Water mentions extract.
According to above-mentioned technical characteristic, the step a in step S1 is specifically, Radix Curcumae, the Radix Angelicae Sinensis that will be broken into tiny fragment
It is separately added into the ethyl alcohol that concentration is 70%, stir within 20 minutes with radix bupleuri dry product, extracted 2 hours using ethyl alcohol, with laggard
Row filtering takes out the solid filter residue that filtering obtains, filtrate is concentrated, and dry 20min, obtains strongly fragrant under conditions of 50 DEG C
Gold, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product alcohol extracting extract, Radix Curcumae, Radix Angelicae Sinensis and the radix bupleuri dry product of addition and the mass ratio of ethyl alcohol are
1:40.
According to above-mentioned technical characteristic, the step b in step S1 is specifically, be added distillation for the filter residue obtained is filtered in alcohol extracting
In water, the weight ratio of filter residue and distilled water is 1:12, is heated to 55 DEG C, is extracted with water 2.5 hours, is then filtered, will filter
Liquid is concentrated, and dry 25min, the water for obtaining Radix Curcumae, Radix Angelicae Sinensis and radix bupleuri dry product mention extract under conditions of 50 DEG C.
According to above-mentioned technical characteristic, in step S2, fresh salvia miltiorrhiza is chosen, after Radix Salviae Miltiorrhizae is sliced, room temperature moisture is added
Stirring, the single-sheet thickness of Radix Salviae Miltiorrhizae slice are 1mm, at reduced pressure conditions, are heated to 70 DEG C of water temperature boilings, extract and by depressurizing back
It receives, after freeze-drying water removal, obtains Salvia root P.E.
According to above-mentioned technical characteristic, step S3 is specifically divided into following steps:
A: carrying out high-temperature baking for endothelium corneum gigeriae galli, until endothelium corneum gigeriae galli surface discolouration, then grinds the endothelium corneum gigeriae galli after baking, and
After grinding, the endothelium corneum gigeriae galli after grinding is added in clear water and is stirred until homogeneous；
B: will stir evenly endothelium corneum gigeriae galli solution and carry out decoction dissolution, become mixing decoction liquor, is filtered, takes to mixing decoction liquor
Filtered fluid is added in centrifuge out, carries out centrifugal clarification, takes clarified solution；
C: clarified solution is cooled down, and ether is added and stands, and separation removal upper layer ether extracts mixed liquor, increases temperature for container
The remaining powder in bottom takes out, as Endothelium Corneum Gigeriae Galli extract.
According to above-mentioned technical characteristic, step S3 is specifically, carry out 120 DEG C of high-temperature bakings, holding temperature baking 8 for endothelium corneum gigeriae galli
Minute to endothelium corneum gigeriae galli surface discolouration, then the endothelium corneum gigeriae galli after baking is ground, is added in clear water and is stirred until homogeneous, addition
The ratio of clear water quality and endothelium corneum gigeriae galli quality is 4:1, and mixed liquor is then increased to 100 DEG C and is decocted, endothelium corneum gigeriae galli is mixed
Liquid dissolution becomes mixing decoction liquor, is filtered to mixing decoction liquor, takes out filtered fluid and is added in centrifuge, be centrifuged clear
Clearly, clarified solution is taken, clarified solution temperature is reduced to 18 DEG C, is added ether, the volume ratio of ether and clarified solution is 3:1, stands 20
Minute, separation removal upper layer ether extracts mixed liquor, increases temperature and takes out the remaining powder of container bottom, as endothelium corneum gigeriae galli
Extract.
According to above-mentioned technical characteristic, step S4 steams 65 seconds specifically, thallus laminariae is added in steamer, and the vapor (steam) temperature of steamer is protected
It holds at 85 DEG C, neutral sylvite is added and pickles to room temperature after natural cooling after taking-up, the weight ratio of neutral sylvite and thallus laminariae is 2:5,
Centrifuge dehydration obtains the liquid containing Thallus Laminariae (Thallus Eckloniae) extract, and then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract.
The present invention is as follows: according to the examination of curative effect acquired results of the Chinese medical extract of embodiment 1-4
| Inspection project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Proliferation of mammary gland dissipation quantity (a) | 233 | 228 | 231 | 230 |
| Kidney functions of expelling toxin (toxin expelling index) | 653 | 587 | 633 | 645 |
| Intestinal microflora (a) | 5267 | 4748 | 4837 | 3594 |
| Recurrence probability | 0.15% | 0.23% | 0.17% | 0.18% |
By upper table testing result it can be found that 50 parts by weight of Radix Curcumae, 45 parts by weight of Radix Angelicae Sinensis, 25 parts by weight of radix bupleuri, pellet is added
Join 30 parts by weight, 12 parts by weight of endothelium corneum gigeriae galli, 14 parts by weight of thallus laminariae when the Chinese medicine of 8 parts by weight of dried orange peel, are able to maintain the cream that preferably disappears and dissipate
Tie effect, at the same will not kidney functions of expelling toxin to drug user and function of intestinal canal impact, and after user takes drugs
The recurrence probability of the proliferation of mammary gland is able to maintain compared with low state.
The working principle of the invention and process for using: the present invention is when extracting the Chinese medical extract of the treatment proliferation of mammary gland, choosing
Take 50 parts by weight of Radix Curcumae, 45 parts by weight of Radix Angelicae Sinensis, 25 parts by weight of radix bupleuri, 30 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of endothelium corneum gigeriae galli, 14 weight of thallus laminariae
Part is measured, the raw medicinal material of 8 parts by weight of dried orange peel is able to maintain the newborn dissipating bind effect that preferably disappears, while will not arrange the kidney of drug user
Malicious function and function of intestinal canal impact, and user takes drugs the recurrence probability of the rear proliferation of mammary gland and is able to maintain lower shape
State extracts the dried orange peel material that parts by weight are 8, can effectively alleviate other Chinese medical extracts to the irritation of human body stomach, extract
The Radix Salviae Miltiorrhizae that the Radix Angelicae Sinensis and parts by weight that parts by weight are 45 are 30, can to human breast's hyperplasia position disappear newborn dissipating bind when, supplement
The case where hot numbness pain and dysphoria and insomnia that blood of human body, activating microcirculation and removing stasis medicinal, and alleviation human body occur, extract the chicken of 12 parts by weight
Interior gold can be relieved the dyspepsia that human body occurs when taking the Chinese medical extract of the treatment proliferation of mammary gland, indirectly reduce Chinese medicine
Influence of the extract to absorption of human body food, human body are not in because of the few food generated, indigestible situation of taking medicine.
Finally, it should be noted that being not intended to restrict the invention the foregoing is merely preferred embodiment of the invention, to the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, for those skilled in the art, still can be with
It modifies the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.It is all
Within the spirit and principles in the present invention, any modification, equivalent replacement, improvement and so on should be included in guarantor of the invention
Within the scope of shield.
Claims (10)
1. a kind of Chinese medical extract for treating the proliferation of mammary gland, which is characterized in that the Chinese medical extract is mainly by the following raw material medicine institute
It is made:
Radix Curcumae 45-55 parts by weight, Radix Angelicae Sinensis 40-50 parts by weight, radix bupleuri 20-30 parts by weight, Radix Salviae Miltiorrhizae 25-35 parts by weight, endothelium corneum gigeriae galli 10-
12 parts by weight, thallus laminariae 12-16 parts by weight, dried orange peel 5-8 parts by weight.
2. a kind of Chinese medical extract for treating the proliferation of mammary gland according to claim 1, which is characterized in that the Chinese medical extract
Mainly as made by the bulk pharmaceutical chemicals of following parts by weight:
50 parts by weight of Radix Curcumae, 45 parts by weight of Radix Angelicae Sinensis, 25 parts by weight of radix bupleuri, 30 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of endothelium corneum gigeriae galli, thallus laminariae 14
Parts by weight, 8 parts by weight of dried orange peel.
3. claim the 1-2 described in any item a kind of extracting methods and application of the Chinese medical extract for treating the proliferation of mammary gland, should
Chinese medical extract is prepared in the following way:
S1, the broken progress ethyl alcohol extraction respectively of Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product and moisture are extracted, filtrate is carried out dense
Contracting forms Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel extracts；
S2, after being sliced Radix Salviae Miltiorrhizae, room temperature moisture is added and stirs, under reduced pressure, is heated to boiling, extract and by depressurizing back
It receives, obtains Salvia root P.E after dry；
S3, endothelium corneum gigeriae galli is subjected to high-temperature baking, is then milled into powder, add water and stir to form homogeneous solution, filtered, take after decoction
Filtered fluid carries out centrifugal clarification out, takes clarified solution, and ether is added and stands, increases temperature after separation, the powder left is chicken
Interior gold extract；
S4, heated at constant temperature will be carried out in thallus laminariae addition steamer, neutral sylvite is added after cooling and pickles, centrifuge, which is dehydrated, to be contained
The liquid of Thallus Laminariae (Thallus Eckloniae) extract, then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract；
S5, obtained Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri, dried orange peel, Radix Salviae Miltiorrhizae, endothelium corneum gigeriae galli and Thallus Laminariae (Thallus Eckloniae) extract are sufficiently mixed, are controlled
Treat the Chinese medical extract of the proliferation of mammary gland.
4. a kind of Chinese medical extract for treating the proliferation of mammary gland according to claim 3 and its extracting method and application, special
Sign is that the step S1 is specifically divided into following steps:
A, alcohol extracting: being broken into tiny fragment for Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product, at room temperature, ethyl alcohol is added
Middle extraction, is filtered solution, and filtrate is concentrated, and obtains alcohol extracting extract；
B, water extracts: the filter residue of filtering being added in distilled water, the filtrate filtered then is concentrated, obtains by heating extraction
Water mentions extract.
5. a kind of Chinese medical extract for treating the proliferation of mammary gland according to claim 4 and its extracting method and application, special
Sign is that the step a in the step S1 is specifically, Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and the dried orange peel dry product that will be broken into tiny fragment
It is separately added into the ethyl alcohol that concentration is 50~80%, stir within 15-25 minutes, extracted 0.5-4 hours using ethyl alcohol, with laggard
Row filtering takes out the solid filter residue that filtering obtains, filtrate is concentrated, and dry 15-30min, obtains under conditions of 50 DEG C
Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product alcohol extracting extract, the Radix Curcumae of addition, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product and ethyl alcohol matter
Amount is than being 1:15-1:50.
6. a kind of Chinese medical extract for treating the proliferation of mammary gland according to claim 4 and its extracting method and application, special
Sign is that the step b in the step S1 by the filter residue obtained is filtered in alcohol extracting specifically, be added in distilled water, filter residue and steaming
The weight ratio of distilled water is 1:8-1:15, is heated to 45-65 DEG C, is extracted with water 1.5-3.5 hours, is then filtered, by filtrate
It is concentrated, dry 15-30min, the water for obtaining Radix Curcumae, Radix Angelicae Sinensis, radix bupleuri and dried orange peel dry product mention extract under conditions of 50 DEG C.
7. a kind of Chinese medical extract for treating the proliferation of mammary gland according to claim 1 and its extracting method and application, special
Sign is, in the step S2, chooses fresh salvia miltiorrhiza, and after Radix Salviae Miltiorrhizae is sliced, the stirring of room temperature moisture is added, Radix Salviae Miltiorrhizae slice
Single-sheet thickness is 0.75-1.25mm, at reduced pressure conditions, is heated to 65 DEG C of -75 DEG C of boilings of water temperature, extracts and by depressurizing back
It receives, after freeze-drying water removal, obtains Salvia root P.E.
8. a kind of Chinese medical extract for treating the proliferation of mammary gland according to claim 1 and its extracting method and application, special
Sign is that the step S3 is specifically divided into following steps:
A: carrying out high-temperature baking for endothelium corneum gigeriae galli, until endothelium corneum gigeriae galli surface discolouration, then grinds the endothelium corneum gigeriae galli after baking, and
After grinding, the endothelium corneum gigeriae galli after grinding is added in clear water and is stirred until homogeneous；
B: will stir evenly endothelium corneum gigeriae galli solution and carry out decoction dissolution, become mixing decoction liquor, is filtered, takes to mixing decoction liquor
Filtered fluid is added in centrifuge out, carries out centrifugal clarification, takes clarified solution；
C: clarified solution is cooled down, and ether is added and stands, and separation removal upper layer ether extracts mixed liquor, increases temperature for container
The remaining powder in bottom takes out, as Endothelium Corneum Gigeriae Galli extract.
9. a kind of Chinese medical extract for treating the proliferation of mammary gland according to claim 7 and its extracting method and application, special
Sign is that for the step S3 specifically, endothelium corneum gigeriae galli is carried out 115-125 DEG C of high-temperature baking, holding temperature toasts 5-10 minutes extremely
Endothelium corneum gigeriae galli surface discolouration then grinds the endothelium corneum gigeriae galli after baking, is added in clear water and is stirred until homogeneous, the clear water matter of addition
The ratio of amount and endothelium corneum gigeriae galli quality is 4:1, and mixed liquor is then increased to 100 DEG C and is decocted, and dissolves endothelium corneum gigeriae galli mixed liquor
As mixing decoction liquor, mixing decoction liquor is filtered, filtered fluid is taken out and is added in centrifuge, carry out centrifugal clarification, take clear
Clarified solution temperature is reduced to 15-22 DEG C by clear liquid, is added ether, and the volume ratio of ether and clarified solution is 3:1, stands 15-25 points
Clock, separation removal upper layer ether extract mixed liquor, increase temperature and take out the remaining powder of container bottom, as endothelium corneum gigeriae galli mentions
Take object.
10. a kind of Chinese medical extract for treating the proliferation of mammary gland according to claim 1 and its extracting method and application, special
Sign is that the step S4 steams 50-75 seconds specifically, thallus laminariae is added in steamer, and the vapor (steam) temperature of steamer is maintained at 80-90
DEG C, neutral sylvite is added and pickles, the weight ratio of neutral sylvite and thallus laminariae is 2:5, centrifuge to room temperature after natural cooling after taking-up
Dehydration obtains the liquid containing Thallus Laminariae (Thallus Eckloniae) extract, and then plus water, ethanol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002847A (en) * | 2006-12-11 | 2007-07-25 | 三峡大学第一临床医学院 | Medicine for treating mazoplasia, and its preparing method |
| CN204599245U (en) * | 2015-01-30 | 2015-09-02 | 漳州金浦三源食品实业有限公司 | A kind of equipment pickling sea-tangle |
| WO2016066058A1 (en) * | 2014-10-28 | 2016-05-06 | 王铁创 | Topical chinese medicinal composition for treating mastitis |
| CN106110173A (en) * | 2016-06-29 | 2016-11-16 | 宁夏金太阳药业有限公司 | A kind of Chinese medicine extract treating cyclomastopathy and extracting method thereof and application |
-
2019
- 2019-06-19 CN CN201910529060.5A patent/CN110101823A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002847A (en) * | 2006-12-11 | 2007-07-25 | 三峡大学第一临床医学院 | Medicine for treating mazoplasia, and its preparing method |
| WO2016066058A1 (en) * | 2014-10-28 | 2016-05-06 | 王铁创 | Topical chinese medicinal composition for treating mastitis |
| CN204599245U (en) * | 2015-01-30 | 2015-09-02 | 漳州金浦三源食品实业有限公司 | A kind of equipment pickling sea-tangle |
| CN106110173A (en) * | 2016-06-29 | 2016-11-16 | 宁夏金太阳药业有限公司 | A kind of Chinese medicine extract treating cyclomastopathy and extracting method thereof and application |
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| Title |
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| 何清邻: "《现代中医临床》", 31 March 2019, 吉林科学技术出版社 * |
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Application publication date: 20190809 |