CN110089735A - A kind of bioactivity joins clever black garlic oral solution and preparation method thereof - Google Patents
A kind of bioactivity joins clever black garlic oral solution and preparation method thereof Download PDFInfo
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- CN110089735A CN110089735A CN201810081957.1A CN201810081957A CN110089735A CN 110089735 A CN110089735 A CN 110089735A CN 201810081957 A CN201810081957 A CN 201810081957A CN 110089735 A CN110089735 A CN 110089735A
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- garlic
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- 229940100688 oral solution Drugs 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 240000002234 Allium sativum Species 0.000 claims abstract description 36
- 235000004611 garlic Nutrition 0.000 claims abstract description 36
- 239000000843 powder Substances 0.000 claims abstract description 28
- 238000000855 fermentation Methods 0.000 claims abstract description 16
- 230000004151 fermentation Effects 0.000 claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 8
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- CKUVNOCSBYYHIS-IRFFNABBSA-N (20S)-ginsenoside Rh2 Chemical compound O([C@H]1CC[C@]2(C)[C@H]3C[C@@H](O)[C@H]4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@@H]4[C@@](C)(O)CCC=C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CKUVNOCSBYYHIS-IRFFNABBSA-N 0.000 abstract description 8
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/20—Products from fruits or vegetables; Preparation or treatment thereof by pickling, e.g. sauerkraut or pickles
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- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
A kind of bioactivity of the present invention joins clever black garlic oral solution and preparation method thereof, garlic is under the condition of high temperature and high humidity, it is curing black garlic using Particular craft fermentation, on the basis of maintaining garlic original composition, oxidation resistance and activation effect improve decades of times for it.Black garlic powder (70%) and ginsenoside RH2 dry powder (10%), lucidum spore powder (10%), pollen pini (5%), pueraria lobata dry powder (5%) is decocted by pulverizing, repeatedly and filter and remove residue, distillation and concentration, alcohol steep, ethanol are concentrated under reduced pressure, prepares and the processing steps such as constant volume, packaging sterilizing, finished product is made, manufactured product is in anti-curing cancers, diabetes, cardiovascular and cerebrovascular disease is more directional and popularity.The present invention eliminates uncooked garlic original penetrating odor during black garlic fermentation maturation, and using the processing method of oral solution, is the functional food that can easily eat of all groups for including old man and children.
Description
Technical field
The invention belongs to field of functional food.
Background technique
Garlic and garlic P.E have Broadspectrum antiphlogistic antivirus action, are common greengrocery flavouring in popular life.
Because can directly kill toxic germ, so it is visually known as " borough chief come out antibiotic ", garlic has many health
Effect is listed in best natural function food all the time.
Continuous research with people to garlic, there is new understanding to it again, and National Cancer Institute is pushing away
Row one is intended to improve national eating habit, so that cancer morbidity is reduced " the design food plan " of half, is being possible to prevent
In the important foodstuffs " pyramid structure figure " of cancer, garlic is listed in top, i.e., most effective fruit.In addition, the center deliver 1989
The epidemiological survey year carried out jointly to Chinese Shandong Province with Beijing Agency for Research on Cancer is as a result, by 685 gastric cancers trouble
Person and 1131 comparisons without cancer personage, its disease incidence of the people of edible garlic lower than the people not eaten 40%, in addition, the center
The iowa,usa state women delivered in 1994 is that investigation result made by object is shown, eats 1 time or more garlic weekly
Crowd suffers from the risk of colorectal cancer, does not only eat the half of garlic people.
Although there are many effective ingredient of garlic, of greatest concern is half Guang ammonia of S- allyl caused by garlic is fermented
Acid, this university of mouth biological resources division have professor He Fengyan to say: it can strengthen immunity the effect of, can activating immune system auxiliary
T cell, this cell play the effect of headquarter in human body, and intracorporal " protective cells " can be ordered to capture and kill germ etc.
Alien enemy.Meanwhile the impurity deposited in the blood vessel of energy official liquidator, enhance the elasticity of blood vessel, improves blood flowing speed, have very
Good pressure stabilization function.
In addition the garlic of fermented maturation, another significant function is can be hypoglycemic, and principle is that the substance has reparation
The islet cells of atrophy slows down the pressure of islet cells, can restore the ability that pancreas islet itself adjusts blood glucose to the maximum extent, and can
Control the generation of diabetic complication.
Summary of the invention
It is simple edible although garlic has many purposes, very strong pungent mouthfeel and annoying implication are had, together
When, disposable large amounts of food, which also will cause, has a stomach upset.To make up above-mentioned deficiency, according to the theory of " integration of drinking and medicinal herbs ", in utilization
Doctor's formula principle of medication and Chinese medicine preparation principle, in conjunction with biological fermentation engineering mode, by the ginseng of the garlic of curing and Chinese herbal medicine
Extract ginsenoside RH2 and lucidum spore powder, pollen pini, pueraria lobata dry powder are pressed formula rate, are produced biologically active
And convenient functional food " joining clever black garlic oral solution ".
Garlic in the present invention is the black garlic of curing after biofermentation, this kind of black garlic is remaining the original composition of garlic
On the basis of oxidation resistance, anti-acid effect improves decades of times, and produces the S- allyl cysteine that garlic is not present,
Ai Qiaoen (a kind of characteristic ingredient with fusing grease) is also produced simultaneously, and the black garlic taste after curing is sour-sweet, without garlic after food
Peculiar smell, be significantly increased to the control efficiency of cancer, diabetes, cardio-cerebrovascular diseases, because in the present invention with addition of Chinese medicine
Ginsenoside RH2, lucidum spore powder, pollen pini, the nontoxic Chinese herbal medicine of pueraria lobata dry powder these types have complementary advantages with black garlic, increase
It prevents and treats the directionality of various diseases and plays the leading action in Chinese medicine therapeutic process.
Wherein, the lucidum spore powder in invention, sweet in flavor, warm-natured, nontoxic, temperature compensation is not dry, is that current cancer patient's rehabilitation is controlled
The drug of first choice for the treatment of.
Ginsenoside RH2 in the present invention is the natural activity composition extracted in ginseng, through numerous internal authority Specialists
Card has the function of good anti-tumor activity, can inhibit the growth of cancer cell, it can also effectively enhance mononuclear macrophage phagocytosis function
Can, cancer cell death can be made, meanwhile, immunity, which can be improved, in it reduces the toxicity of chemicotherapy.
Pollen pini in the present invention, it is sweet in flavor, it is warm-natured, it is nontoxic, cardiopulmonary are moistened, it is hypoglycemic can to enhance control for benefiting qi and checking blood
Effect.
The effect of kudzu-vine root powder in the present invention, heat-clearing and fire-reducing, enriching yin removing toxic substances, rising Yang promote the production of body fluid, stimulating appetite, mainly there is drop
Rouge decompression, fall fire, clearing heat and detoxicating, rising Yang expelling pathogenic factors from muscles and skin, spasmolysis and analgesia, promoting eruption antidiarrheal, increases brain and coronal blood glucose, improves that brain is micro- to follow
Ring and other effects.
The formula rate of said herbal medicine and curing black garlic: by weight: ginsenoside RH2 dry powder 10%, Reishi sporule
Powder 10%, pollen pini 5%, pueraria lobata dry powder 5%, black garlic dry powder 70%.Specific implementation process, selection kind: 1. garlic is white skin garlic,
Agriculture is residual when detection reaches standard.2. lucidum spore powder, ginsenoside RH2 dry powder, pollen pini, pueraria lobata dry powder buy raw material i.e.
It can.
2, cleaning and shaping: the root and crust of garlic are cleaned up, is stayed two layers of endothelium, size one is to each garlic is in 40-
50 grams are advisable.
3, it cleaning and immersion: after garlic is cleaned repeatedly with clear water, with 3 ‰ salt well water, impregnates garlic 1-2 hours.
4, step temperature rising formula spray fermentation: 1. fermenting cellar and fermenting case must be wooden, forbid have metallics to be mixed into hair
Between ferment；2. 25-30 DEG C of one grade fermemtation, humidity 70%, for three days on end；Second order fermentation, 40-45 DEG C, humidity 70%, for three days on end；Three
55-60 DEG C of grade fermentation, humidity 70%, for three days on end；70-75 DEG C of level four fermentation, humidity 70%, for three days on end；Pyatyi fermentation 80-85
DEG C, humidity 70%, for three days on end；Six grades ferment 85-90 DEG C, humidity 70%, for three days on end；3. spray, by glutamic acid, lysine,
Each one kilogram of cysteine is made into aqueous solution with pure water, and ratio 1 ‰, in every grade of fermentation, spray is primary daily.
5, cooked at constant: after above-mentioned operation, the black garlic after fermentation is transported to constant temperature warehouse and further cures and dries.It is permanent
The temperature in warm warehouse is set in 25 DEG C, and humidity 50%, continuous ripening is dried 20 days.
6, machine barking: with skinning machine by moisture content with lower than 10% curing black garlic crust remove it is spare.
7, freeze-drying crushes: black garlic is ground into 180 mesh fine powders under subzero 70 DEG C of low-temperature condition with freeze drier,
It is spare.
8, ganoderma lucidum robe powder, ginsenoside RH2 dry powder, pollen pini, pueraria lobata dry powder original powder micronizer is further
Crushing makes its fineness reach 180 mesh, spare.
9, it decocts: above-mentioned each material being mixed evenly by formula rate, is put into Decocting pot, 5-8 times of water is added,
It decocting 2-3 hours, filters out juice and save, remaining dregs of a decoction adds 3-5 times of water, it decocts 1-2 hours, after filtering out two juice,
Again plus 2-4 times of water, after decocting 1-2 hour, filter third juice removes the dregs of a decoction, then will successively filter after juice merging three times spare.
10, it processes: concentrate liquid is added corresponding to 2 grams of crude drug in whole of concentration to 1 milliliter in filtrate distillation and concentration after letting cool
95% ethyl alcohol of 2 times of amounts stirs evenly placement 24 hours, recycles ethyl alcohol, and the xylitol that the 5-30% of the total amount containing oral solution is added stirs evenly,
Filter vacuum vacuum distillation is concentrated into medicinal extract shape, is diluted with appropriate distilled water, filtering, by the leaching of 500 grams of -800 grams of bulk pharmaceutical chemicals
Cream final volume is that 1000 milliliters of constant volumes are prepared.
11, packaging sterilization: juice is refrigerated, and is filtered, is packaged in 5-10 milliliters of bottles；With 115 DEG C high-temperature sterilization 30 minutes
To obtain the final product.
In addition to water and xylitol, which is 100%.
Bioactivity joins clever black garlic oral solution after the preparation of above-mentioned technique, is proved by food analysis inspection result, amino
The content of acid increases 2.5 times than garlic in this product, and the content of polyphenol increases 22 times than Common garlic, lipid soluble ingredients
Content than Common garlic be even more to increase 79 times.Ganoderma lucidum robe powder, ginsenoside RH2 dry powder, pollen pini, Pueraria lobota in the invention
Root dry powder compensates for the deficiency in black garlic insufficiency face, make the invention to cancer, diabetes, cardio-cerebrovascular diseases prevention and treatment more
There is directionality.
In order to verify the function affect of the invention, for cancer patient, we are real under the principle for abiding by ethics
The clinical trial for having applied three groups of various cancers patients illustrates this to them after finding out test-meal and joining clever black garlic piece volunteer
The intention of experiment has started the experiment for three of them month on the basis of obtaining their understandings, this experiment schedule and inspection
Project is carried out according to the regulation of Declaration of Helsinki, and final conclusion is that the invention is can to become highly-safe pre- anti-cancer
Food.
Claims (6)
1. the present invention is by the black garlic after the fermented maturation of garlic with addition of 4 taste Chinese medicinal compositions, formula rate is by weight are as follows: people
Join saponin(e RH2 dry powder 10%, lucidum spore powder 10%, pollen pini 5%, pueraria lobata dry powder 5%, black garlic dry powder 70%, after extracted
Oral solution is made.
2. being fermented maturation according to the garlic of the 1st description, after wherein garlic needs to be cleaned repeatedly with clear water, then with 3 ‰ well
Saline immersion 1-2 hours, pull out leaching do it is spare.
3. fermentation is fermented using step temperature rising formula: in no any metallics according to the fermentation maturation of the garlic of the 1st description
Wooden fermenting cellar the garlic after cleaning is piled up, 25-30 DEG C of one grade fermemtation, humidity 70%, for three days on end；Second order fermentation,
40-45 DEG C, humidity 70%, for three days on end；55-60 DEG C of three grade fermemtation, humidity 70%, for three days on end；It is 70-75 DEG C of level four fermentation, wet
Degree 70%, for three days on end；Pyatyi is fermented 80-85 DEG C, humidity 70%, for three days on end；Six grades ferment 85-90 DEG C, humidity 70%, continuously
3 days.
4. according to the garlic of the 3rd description ferment maturation, spray compositing acid solution in the process: by glutamic acid, lysine,
Each 1 kilogram of cysteine, in 1 ‰ ratio pure water wiring solution-forming, in every grade of fermentation, spray 1 time, sprays 5 every time daily
Kg of solution.
5. according to the fermentation maturation of the garlic of the 2nd to 4 description: after above-mentioned operation, the black garlic for the curing that will ferment is transported to constant temperature
Warehouse, further cooked at constant: the temperature in constant temperature warehouse is set as 25 DEG C, and humidity 50%, continuous ripening is dried 20 days.
6. according to black garlic raw material described in the 1st article of formula and the 2-5 articles, their extraction and process for preparation it is following or and this
It is significant identical: each material being mixed evenly by formula rate 1., is put into extractor, 5-8 times of water is added, decocts 2-3
Hour, filter juice saves；2. remaining dregs of a decoction adds 3-5 times of water, decoct 1-2 hours, two juice of filter save；3. adding 2- again
4 times of water, after decocting 1-2 hour, filter third juice removes the dregs of a decoction, then will successively filter after juice merging three times spare；4. will filter
When liquid is further concentrated to 1 milliliter of medical fluid and is equivalent to 2 grams of crude drug in whole, let cool；5. 95% ethyl alcohol of 2 times of medical fluid amounts is added, placement is stirred evenly
24 hours；6. after ethyl alcohol to be recycled, the xylitol that the 5-30% of the total amount containing oral solution is added is stirred evenly, filter vacuum is evaporated under reduced pressure
It is concentrated into medicinal extract shape, is diluted with appropriate distilled water, is diluted with appropriate distilled water, filtering, by the medicinal extract of 500 grams of -800 grams of bulk pharmaceutical chemicals
Final volume is that 1000 milliliters of constant volumes are prepared.
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| CN112335875A (en) * | 2019-08-09 | 2021-02-09 | 株式会社艾福瑞特 | Health functional composition with blood circulation improving effect |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104544107A (en) * | 2013-10-12 | 2015-04-29 | 陈岐 | Bioactive ginsenoside/Ganoderma lucidum spore/black garlic capsule and preparation method thereof |
| CN104585649A (en) * | 2013-11-01 | 2015-05-06 | 陈久顺 | Bioactive ginseng, Ganoderma lucidum and black garlic oral liquid and preparation method thereof |
| WO2016035916A1 (en) * | 2014-09-05 | 2016-03-10 | 영농조합법인 태영농수산 | Method for making black garlic |
| CN105875960A (en) * | 2015-01-20 | 2016-08-24 | 天地成微生物技术(北京)有限公司 | Active black garlic instant tea and preparation method thereof |
| CN106135420A (en) * | 2015-04-27 | 2016-11-23 | 陈久顺 | A kind of biologically active solid black Bulbus Allii milk tea and preparation method |
-
2018
- 2018-01-29 CN CN201810081957.1A patent/CN110089735A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104544107A (en) * | 2013-10-12 | 2015-04-29 | 陈岐 | Bioactive ginsenoside/Ganoderma lucidum spore/black garlic capsule and preparation method thereof |
| CN104585649A (en) * | 2013-11-01 | 2015-05-06 | 陈久顺 | Bioactive ginseng, Ganoderma lucidum and black garlic oral liquid and preparation method thereof |
| WO2016035916A1 (en) * | 2014-09-05 | 2016-03-10 | 영농조합법인 태영농수산 | Method for making black garlic |
| CN105875960A (en) * | 2015-01-20 | 2016-08-24 | 天地成微生物技术(北京)有限公司 | Active black garlic instant tea and preparation method thereof |
| CN106135420A (en) * | 2015-04-27 | 2016-11-23 | 陈久顺 | A kind of biologically active solid black Bulbus Allii milk tea and preparation method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112335875A (en) * | 2019-08-09 | 2021-02-09 | 株式会社艾福瑞特 | Health functional composition with blood circulation improving effect |
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