CN104585649A - Bioactive ginseng, Ganoderma lucidum and black garlic oral liquid and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of functional foods. Garlic is fermented through using a unique technology under high temperature and high humidity conditions to form maturated black garlic, the maturated black garlic maintains original components of the garlic, and the oxidation resistance and the activation effect of the maturated black garlic are dozens of times higher than those of the garlic. A bioactive ginseng, Ganoderma lucidum and black garlic oral liquid is prepared through the following steps: carrying out superfine grinding on (70% of) black garlic powder, (10% of) ginsenoside RH2 powder, (10% of) Ganoderma lucidum spore powder, (5% of) pine pollen and (5% of) dry Kudzuvine root powder, repeatedly decocting and filtering to remove residues, carrying out distilling concentration, carrying out ethanol extraction, carrying out reduced pressure concentration on the obtained ethanol liquid, preparing, adding distilled water to a constant volume, and carrying out packaging sterilization. The bioactive ginseng, Ganoderma lucidum and black garlic oral liquid has directivity and universality in the prevention and treatment of cancers, diabetes and cardiovascular diseases. The original irritation smell of raw garlic is eliminated in the black garlic fermenting maturation process, and an oral liquid processing mode is adopted to form a functional food easily eaten by the elderly, children and other people.

Description

Clever black garlic oral liquid of a kind of biologically active ginseng and preparation method thereof

Technical field

The invention belongs to field of functional food.

Background technology

Garlic and garlic P.E have Broadspectrum antiphlogistic antivirus action, are greengrocery flavouring conventional in popular life.Because can directly kill poisonous germ, so it is called " borough chief's antibiotic out " visually, garlic has a lot of health efficacy, is listed in best natural function food all the time.

Along with people are to the continuous research of garlic, new understanding has been had again to it, National Cancer Institute is being carried out one and is being intended to improve national eating habit, cancer morbidity is reduced " plan of design food " of half, in the important foodstuffs " pyramid structure figure " of likely pre-anti-cancer, garlic is listed in top, namely the most effective.In addition, this center deliver 1989 with Beijing Agency for Research on Cancer jointly to the epidemiology survey result that Chinese Shandong Province carries out, by there is no the comparison of cancer personage to 685 patients with gastric cancer and 1131, its incidence of disease of the people of edible garlic is lower than the people do not eaten by 40%, in addition, the investigation result display that the iowa,usa state women that this center was delivered in 1994 does for object, the crowd of edible more than 1 time garlic weekly, suffer from the risk of colorectal cancer, only have the half of not eating garlic people.

Although the effective ingredient of garlic is a lot, but of greatest concern is that garlic is through the S-allyl cysteine produced that ferments, Nihon University biological resources division has professor He Fengyan to say: effect of its energy develop immunitypty, the helper cell of energy activating immune system, this cell plays the effect of headquarter in human body, " protective cells " in order body can catch and kill the alien enemies such as germ.Meanwhile, the impurity deposited in the blood vessel of energy official liquidator, strengthens the elasticity of blood vessel, improves blood flowing speed, have good pressure stabilization function.

In addition through the garlic of maturation of fermenting, another remarkable function is can be hypoglycemic, its principle is the pressure that this material has that the islet cells repairing atrophy slows down islet cells, can recover the ability of pancreas islet self-regulation blood sugar to greatest extent, and the generation of controlled diabetic complication processed.

Summary of the invention

Although garlic has many purposes, simply edible, have very strong pungent mouthfeel and annoying implication, meanwhile, disposable a large amount of edible also can causing is had a stomach upset.For making up above-mentioned deficiency, according to the theory of " integration of drinking and medicinal herbs ", utilize traditional Chinese medical science formula principle of medication and Chinese medicine preparation principle, in conjunction with biological fermentation engineering mode, by the ginseng extract ginsenoside RH2 of the garlic of slaking and Chinese herbal medicine and lucidum spore powder, formula rate pressed by pollen pini, root of kudzu vine dry powder, produces to have bioactive and the functional food of instant " joins clever black garlic oral liquid ".

Garlic in the present invention is the black garlic of slaking after biofermentation, this kind of black garlic oxidation resistance on the basis remaining the original composition of garlic, anti-acid effect improves decades of times, and create the non-existent S-allyl cysteine of garlic, also create Ai Qiaoen (a kind of characteristic composition with fusing grease) simultaneously, black garlicky road after slaking is sour-sweet, without the peculiar smell of garlic after food, to cancer, diabetes, the prevention effect of cardio-cerebrovascular diseases is significantly increased, because of in the present invention with addition of Chinese medicine ginsenoside RH2, lucidum spore powder, pollen pini, this several nontoxic Chinese herbal medicine of root of kudzu vine dry powder, have complementary advantages with black garlic, add the directionality of preventing and treating various disease and the leading action served in treatment by Chinese herbs process.

Wherein, the lucidum spore powder in invention, taste is sweet, warm in nature, nontoxic, and temperature compensation is not dry, is the drug of first choice of current cancer patient's rehabilitation.

Ginsenoside RH2 in the present invention is the natural activity composition extracted in ginseng, be expounded through peer review through numerous internal authority and there is good antitumor activity function, the growth of energy inhibition cancer cell, it also effectively can strengthen mononuclear-macrophage phagocytic function, cancer cell death can be made, meanwhile, it can improve the toxicity that immunity reduces chemicotherapy.

Pollen pini in the present invention, taste is sweet, warm in nature, nontoxic, moistens cardiopulmonary, benefiting qi and checking blood, can strengthen and control hypoglycemic effect.

Kudzu-vine root powder in the present invention, heat-clearing and fire-reducing, enriching yin removing toxic substances, rises that sun promotes the production of body fluid, effect of stimulating appetite, mainly contains lipopenicillinase, step-down, falls fire, clearing heat and detoxicating, rise positive expelling pathogenic factors from muscles and skin, spasmolysis and analgesia, promoting eruption antidiarrheal, increase brain and crown blood sugar, improve the effects such as brain microcirculation.

The formula rate of said herbal medicine and the black garlic of slaking: by weight: ginsenoside RH2 dry powder 10%, lucidum spore powder 10%, pollen pini 5%, root of kudzu vine dry powder 5%, black garlic dry powder 70%.

Specific implementation process

1, selection kind: 1. garlic is white skin garlic, during detection, agriculture is residual reaches standard.2. lucidum spore powder, ginsenoside RH2 dry powder, pollen pini, raw material bought by root of kudzu vine dry powder.

2, cleaning and shaping: the coring and the crust that clean out garlic, stay endothelium two-layer, size one to, each head of garlic is advisable at 40-50 gram.

3, cleaning and immersion: after garlic is cleaned repeatedly with clear water, with the salt well water of 3 ‰, dipping garlic 1-2 hour.

4, step temp. rising formula spray fermentation: 1. fermenting cellar and fermenting case must be wooden, forbid have metallics to be mixed into sweathouse; 2. one grade fermemtation 25-30 DEG C, humidity 70%, for three days on end; Second order fermentation, 40-45 DEG C, humidity 70%, for three days on end; Three grade fermemtation 55-60 DEG C, humidity 70%, for three days on end; Level Four fermentation 70-75 DEG C, humidity 70%, for three days on end; Pyatyi fermentation 80-85 DEG C, humidity 70%, for three days on end; Six grades of fermentation 85-90 DEG C, humidity 70%, for three days on end; 3., spray, by glutamic acid, lysine, each one kilogram of cysteine is made into the aqueous solution with pure water, ratio 1 ‰, and when every grade of fermentation, every day sprays once.

5, cooked at constant: after above-mentioned operation, is transported to the further slaking in constant temperature warehouse and drying by the black garlic after fermentation.The temperature in constant temperature warehouse is set in 25 DEG C, humidity 50%, dry 20 days of continuous ripening.

6, machine barking: moisture content is removed for subsequent use with the slaking black garlic crust lower than 10% with skinning machine.

7, freeze-drying is pulverized: with freeze drier, under the low-temperature condition of subzero 70 DEG C, black garlic is ground into 180 order fine powders, for subsequent use.

8, glossy ganoderma robe powder, ginsenoside RH2 dry powder, pollen pini, root of kudzu vine dry powder former powder micronizer are pulverized further make its fineness all reach 180 orders, for subsequent use.

9, decoct: above-mentioned each material is pressed formula rate mixing and stirring, put into Decocting pot, add 5-8 water doubly, decoct 2-3 hour, leach a juice to preserve, all the other dregs of a decoction add 3-5 water doubly again, decoct 1-2 hour, after leaching two juice, add 2-4 water doubly again, decoct after 1-2 hour, filter the 3rd juice removes the dregs of a decoction, then will successively filter for subsequent use after merging for three juice.

10, process: concentration filtrate distillation and concentration to 1 milliliter being corresponded to crude drug in whole 2 grams, 95% ethanol of concentrate liquid 2 times amount is added after letting cool, stir evenly placement 24 hours, reclaim ethanol, the xylitol added containing the 5-30% of oral liquid total amount stirs evenly, and filter vacuum decompression distillation is concentrated into medicinal extract shape, uses appropriate distilled water diluting, filtering, is 1000 milliliters of constant volume preparations by the medicinal extract final volume of 500 grams of-800 grams of bulk drugs.

11, pack sterilization: refrigerated by juice, filter, be packaged in 5-10 milliliter bottle; With 115 DEG C of high-temperature sterilizations 30 minutes and get final product.

Dewater and xylitol outside, each consumption of the whole medicinal raw material of this formula be 100%.

The clever black garlic oral liquid of biologically active ginseng is after above-mentioned technique preparation, proved by food analysis check result, amino acid whose content adds 2.5 times than garlic in this product, and the content of polyphenol adds 22 times than Common garlic, and the content of lipid soluble ingredients is more the increase in 79 times than Common garlic.Glossy ganoderma robe powder in this invention, ginsenoside RH2 dry powder, pollen pini, root of kudzu vine dry powder compensate for the deficiency in black garlic insufficiency face, make this invention more have directionality to the control of cancer, diabetes, cardio-cerebrovascular diseases.

In order to verify the function affect of this invention, for cancer patient, under the principle observing ethics, we implement the clinical trial of three groups of various cancers patients, after finding out the clever black garlic pieces volunteer of test-meal ginseng, the intention of this experiment is described to them, on the basis obtaining their understanding, start as its trimestral experiment, this experiment schedule and inspection item all carry out according to the regulation of Declaration of Helsinki, final conclusion is, this invention is the food that can become the high pre-anti-cancer of security.

Claims (6)

1. the present invention is made up of with addition of 4 taste Chinese medicines the black garlic of garlic after fermentation maturation, its formula rate is by weight: ginsenoside RH2 dry powder 10%, lucidum spore powder 10%, pollen pini 5%, root of kudzu vine dry powder 5%, black garlic dry powder 70%, after extracting, make oral liquid.

2. according to the garlic fermentation maturation of the description of the 1st, after wherein garlic needs repeatedly to clean with clear water, then with 3 ‰ salt well water dipping 1-2 hour, pull out drench do for subsequent use.

3., according to the garlic fermentation maturation of the description of the 1st, fermentation adopts the fermentation of step temp. rising formula: piled up by the garlic after cleaning at the wooden fermenting cellar without any metallics, one grade fermemtation 25-30 DEG C, humidity 70%, for three days on end; Second order fermentation, 40-45 DEG C, humidity 70%, for three days on end; Three grade fermemtation 55-60 DEG C, humidity 70%, for three days on end; Level Four fermentation 70-75 DEG C, humidity 70%, for three days on end; Pyatyi fermentation 80-85 DEG C, humidity 70%, for three days on end; Six grades of fermentation 85-90 DEG C, humidity 70%, for three days on end.

4. according to the garlic fermentation maturation of the description of the 3rd, compositing acid solution is sprayed: by glutamic acid, lysine, each 1 kilogram of cysteine, the pure water wiring solution-forming of the ratio in 1 ‰, when every grade of fermentation in process, spray 1 every day, each spray 5 kg of solution.

5. according to the garlic fermentation maturation of the description of the 2 to 4: after above-mentioned operation, the black garlic of fermentation slaking is transported to constant temperature warehouse, further cooked at constant: the temperature in constant temperature warehouse is set as 25 DEG C, humidity 50%, dry 20 days of continuous ripening.

6. the black garlic raw material according to the 1st article of described formula and 2-5 article, their extraction and process for preparation be as follows or significantly identical therewith: 1. each material is pressed formula rate mixing and stirring, put into extractor, add 5-8 water doubly, decoct 2-3 hour, filter juice is preserved; 2. all the other dregs of a decoction add 3-5 water doubly again, decoct 1-2 hour, filter two juice and preserve; 3. add 2-4 water doubly again, decoct after 1-2 hour, filter the 3rd juice removes the dregs of a decoction, then will successively filter for subsequent use after merging for three juice; 4. filtrate is concentrated into 1 milliliter of liquid when being equivalent to crude drug in whole 2 grams again, lets cool; 5. add 95% ethanol of liquid 2 times amount, stir evenly placement 24 hours; 6., after ethanol to be recycled, the xylitol added containing the 5-30% of oral liquid total amount stirs evenly, and filter vacuum decompression distillation is concentrated into medicinal extract shape, use appropriate distilled water diluting, using appropriate distilled water diluting, filter, is 1000 milliliters of constant volume preparations by the medicinal extract final volume of 500 grams of-800 grams of bulk drugs.