CN110079098A - 一种流涎法制备的多用途膜易揭材料及其应用 - Google Patents

一种流涎法制备的多用途膜易揭材料及其应用 Download PDF

Info

Publication number
CN110079098A
CN110079098A CN201910183522.2A CN201910183522A CN110079098A CN 110079098 A CN110079098 A CN 110079098A CN 201910183522 A CN201910183522 A CN 201910183522A CN 110079098 A CN110079098 A CN 110079098A
Authority
CN
China
Prior art keywords
parts
casting method
film
easily takes
collagen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910183522.2A
Other languages
English (en)
Inventor
李健
王广
陈渊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sichuan Hou Cheng Novel Material Co Ltd
Original Assignee
Sichuan Hou Cheng Novel Material Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Hou Cheng Novel Material Co Ltd filed Critical Sichuan Hou Cheng Novel Material Co Ltd
Priority to CN201910183522.2A priority Critical patent/CN110079098A/zh
Publication of CN110079098A publication Critical patent/CN110079098A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00—Characterised by the use of proteins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2401/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2401/08—Cellulose derivatives
    • C08J2401/26—Cellulose ethers
    • C08J2401/28—Alkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
    • C08J2405/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2429/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
    • C08J2429/02—Homopolymers or copolymers of unsaturated alcohols
    • C08J2429/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/05—Alcohols; Metal alcoholates
    • C08K5/053—Polyhydroxylic alcohols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/07—Aldehydes; Ketones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/09—Carboxylic acids; Metal salts thereof; Anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明涉及流涎法制备的多用途膜易揭材料及其应用，所述流涎法制备的多用途膜易揭材料具有机械强度高、韧性高、可缓释所负载的活性物质、与组织不易粘连、不易吸水，储存稳定性高、膜本身具有抗菌活性，不易变质等诸多优异的性能，可应用于制备面膜、生物敷料、胶囊壳等多个领域，且制备方法简单、适于工业化生产。

Description

一种流涎法制备的多用途膜易揭材料及其应用
技术领域
本发明涉及高分子材料领域，具体涉及一种流涎法制备的多用途膜易揭材料及其应用。
背景技术
适宜的成膜材料经加工而成的膜被广泛应用于医药、化妆品、食品、水处理、物质分离、包装等诸多领域。随着科技的不断发展，可用于制备膜的成膜材料种类不断被丰富，按照其来源的不同包括天然高分子材料，如明胶、淀粉、海藻酸及其盐、壳聚糖、阿拉伯胶、虫胶等；合成高分子材料，如聚乙烯醇类、纤维素类、丙烯酸类等。膜的制备方法也先后发展出流涎法、纺丝法、复合膜化法、膨润法、交联法、电子辐射法、双向拉伸法、冻结干燥法、结晶度调整法等，其中流涎法，又称匀浆制膜法、涂膜法，为国内外应用广泛的一种制膜方法，系将制膜材料溶于适当的溶剂后，滤过，然后涂膜成所需厚度，干燥后即可，具有工艺简单、适合工业化生产、所制备的膜厚度可调等诸多优点，如中国专利CN103570958A公开了通过流涎法制备了一种可食性壳聚糖-胶原蛋白抗菌膜，可应用于食品的保鲜；CN101927030A公开了一种采用流涎法制备的含有纳米银、锌、铋的生物敷料，可用于制备治疗阴道炎、宫颈炎、宫颈糜烂、褥疮、皮肤溃疡、烧伤、烫伤、创伤、皮肤炎症、手足癣的药物。
胶原蛋白为一个蛋白质家族，主要存在于皮肤、骨骼、软骨、肌腱等组织中，包括I型胶原蛋白、II型胶原蛋白、III型胶原蛋白、IV型胶原蛋白。胶原蛋白不仅来源广泛，还具有诸多特有的生理功能，如：胶原蛋白可促进血小板凝聚，从而可用于止血；相对于其他蛋白质，胶原蛋白具有低抗原性，因此，可用于制备低抗原性材料；胶原蛋白还具有细胞生长的促进活性，可用作细胞培养的基质材料，用作伤口敷料时，还具有促进伤口愈合的作用；胶原蛋白还具有良好的生物相容性，用作植入材料时，可被机体吸收；胶原蛋白还具有优良的生物可降解性，可广泛应用于器官移植材料等。使用胶原蛋白的制备膜材料虽然已有报道，但由于胶原蛋白自身存在机械强度低、脆度高、易破碎、易滋生细菌、易变质、用作药物载体时，释放速率单一等问题，制约了以胶原蛋白作为成膜材料所制备的膜材料的应用范围。
为了克服以胶原蛋白为成膜材料所制备的膜材料所存在问题，有必要开发一种以胶原蛋白为成膜材料的多用途膜，以扩大以胶原蛋白为成膜材料所制备的膜材料的应用范围。
发明内容
本发明的目的是提供一种流涎法制备的多用途膜易揭材料及其应用。
一方面，本发明提供一种流涎法制备的多用途膜易揭材料，由胶原蛋白20-30份、壳聚糖3-5份、纤维素及其衍生物3-5份、聚乙烯醇2-3份、甲基丙烯酸酐1-2份、交联剂1-2份、增塑剂3-5份，经流涎法制成。
优选的，所述流涎法制备的多用途膜易揭材料由胶原蛋白24-26份、壳聚糖4份、纤维素及其衍生物4份、聚乙烯醇2.5份、甲基丙烯酸酐1.5份、交联剂1.5份、增塑剂4份，经流涎法制成。
更优选的，所述流涎法制备的多用途膜易揭材料由胶原蛋白25份、壳聚糖4份、纤维素及其衍生物4份、聚乙烯醇2.5份、甲基丙烯酸酐1.5份、交联剂1.5份、增塑剂4份，经流涎法制成。
优选的，所述胶原蛋白为脱内毒素I型胶原蛋白，所述纤维素为乙基纤维素，所述交联剂为戊二醛，所述增塑剂选自：甘油、丙二醇、甘露糖醇、山梨糖醇木糖醇、麦芽糖醇液体石蜡、甲酰胺中的一种或多种。
另一方面，本发明提供流涎法制备的多用途膜易揭材料制备面膜的用途，所述流涎法制备的多用途膜易揭材料由胶原蛋白20-30份、壳聚糖3-5份、纤维素及其衍生物3-5份、聚乙烯醇2-3份、甲基丙烯酸酐1-2份、交联剂1-2份、增塑剂3-5份，经流涎法制成。
优选的所述流涎法制备的多用途膜易揭材料由胶原蛋白24-26份、壳聚糖4份、纤维素及其衍生物4份、聚乙烯醇2.5份、甲基丙烯酸酐1.5份、交联剂1.5份、增塑剂4份，经流涎法制成。
更优选的，所述流涎法制备的多用途膜易揭材料由胶原蛋白25份、壳聚糖4份、纤维素及其衍生物4份、聚乙烯醇2.5份、甲基丙烯酸酐1.5份、交联剂1.5份、增塑剂4份，经流涎法制成。
优选的，所述胶原蛋白为脱内毒素I型胶原蛋白，所述纤维素为乙基纤维素，所述交联剂为戊二醛，所述增塑剂选自：甘油、丙二醇、甘露糖醇、山梨糖醇木糖醇、麦芽糖醇液体石蜡、甲酰胺中的一种或多种。
再一个方面，本发明提供所述经流涎法制备的多用途膜易揭材料制备得到的面膜，其中经流涎法制备的多用途膜易揭材料用作面膜基材。
优选的，所述经流涎法制备的多用途膜易揭材料中还负载有补水保湿剂、美白剂、抗氧化剂、促渗剂等的一种或多种。
另一个方面，本发明提供所述流涎法制备的多用途膜易揭材料制备生物敷料中的用途，所述流涎法制备的多用途膜易揭材料由胶原蛋白20-30份、壳聚糖3-5份、纤维素及其衍生物3-5份、聚乙烯醇2-3份、甲基丙烯酸酐1-2份、交联剂1-2份、增塑剂3-5份，经流涎法制成。
优选的所述流涎法制备的多用途膜易揭材料由胶原蛋白24-26份、壳聚糖4份、纤维素及其衍生物4份、聚乙烯醇2.5份、甲基丙烯酸酐1.5份、交联剂1.5份、增塑剂4份，经流涎法制成。
更优选的，所述流涎法制备的多用途膜易揭材料由胶原蛋白25份、壳聚糖4份、纤维素及其衍生物4份、聚乙烯醇2.5份、甲基丙烯酸酐1.5份、交联剂1.5份、增塑剂4份，经流涎法制成。
优选的，所述胶原蛋白为脱内毒素I型胶原蛋白，所述纤维素为乙基纤维素，所述交联剂为戊二醛，所述增塑剂选自：甘油、丙二醇、甘露糖醇、山梨糖醇木糖醇、麦芽糖醇液体石蜡、甲酰胺中的一种或多种。
再一个方面，本发明提供所述经流涎法制备的多用途膜易揭材料制备得到的生物敷料，其中经流涎法制备的多用途膜易揭材料用作生物敷料基材。
优选的，所述经流涎法制备的多用途膜易揭材料中还负载有药物。
优选的，所述药物选自止痛剂、止血剂、抑菌剂、抗炎剂中的一种或多种。
另一个方面，本发明提供所述流涎法制备的多用途膜易揭材料制备硬胶囊壳中的用途，所述流涎法制备的多用途膜易揭材料由胶原蛋白20-30份、壳聚糖3-5份、纤维素及其衍生物3-5份、聚乙烯醇2-3份、甲基丙烯酸酐1-2份、交联剂1-2份、增塑剂3-5份，经流涎法制成。
优选的所述流涎法制备的多用途膜易揭材料由胶原蛋白24-26份、壳聚糖4份、纤维素及其衍生物4份、聚乙烯醇2.5份、甲基丙烯酸酐1.5份、交联剂1.5份、增塑剂4份，经流涎法制成。
更优选的，所述流涎法制备的多用途膜易揭材料由胶原蛋白25份、壳聚糖4份、纤维素及其衍生物4份、聚乙烯醇2.5份、甲基丙烯酸酐1.5份、交联剂1.5份、增塑剂4份，经流涎法制成。
优选的，所述胶原蛋白为脱内毒素I型胶原蛋白，所述纤维素为乙基纤维素，所述交联剂为戊二醛，所述增塑剂选自：甘油、丙二醇、甘露糖醇、山梨糖醇木糖醇、麦芽糖醇液体石蜡、甲酰胺中的一种或多种。
再一个方面，本发明提供所述经流涎法制备的多用途膜易揭材料制备得到的胶囊壳。
再一个方面，本发明提供经流涎法制备的多用途膜易揭材料的制备方法，包括以下步骤：
(1)备料：按配方称取各原料；
(2)溶解：将配方量的胶原蛋白、壳聚糖、纤维素及其衍生物、聚乙烯醇添加至稀酸溶液中，在20-40℃条件下下搅拌直至完全溶解，其中胶原蛋白的固含量为0.5％-5％；
(3)交联：在步骤(2)所得的溶液中添加甲基丙烯酸酐搅拌均匀后，边搅拌边缓慢加入交联剂，交联剂添加完成后继续搅拌1-2h，过滤后添加增塑剂，静置消泡；
(4)制膜：将步骤(3)所得消泡后的溶液于玻璃板制备成所需厚度的膜，干燥后即得。
优选的，所述稀酸溶液选自2％醋酸溶液、1％盐酸溶液、1％硫酸溶液等；
优选的，所述步骤(2)中在30℃条件下下搅拌直至完全溶解，其中胶原蛋白的固含量为1％-4％；
更优选的，所述步骤(2)中在30℃条件下下搅拌直至完全溶解，其中胶原蛋白的固含量为2％。
本发明有益效果：
本发明经流涎法制备的多用途膜易揭材料由于原料中添加了纤维素及其衍生物、聚乙烯醇、甲基丙烯酸酐所最终获得的多用途膜易揭材料具有机械强度高、韧性高、可缓释所负载的活性物质、与组织不易粘连、不易吸水，储存稳定性高、膜本身具有抗菌活性，不易变质等诸多优异的性能，可应用于制备面膜、生物敷料、胶囊壳等多个领域，且制备方法简单、适于工业化生产。
使用本发明经流涎法制备的多用途膜易揭材料制备的面膜，由于所使用的经流涎法制备的多用途膜易揭材料具有缓释所负载的活性物质而能使面膜中有效成分缓慢释放，有利于有效成分的吸收，且自身具有抑菌活性，无需添加其他化学合成类的防腐剂，具有面膜柔顺，对皮肤无刺激，面膜机械强度高，韧性高，附着力好，透气性高，易施用和揭除，无需使用额外的基材的优点。
使用本发明经流涎法制备的多用途膜易揭材料制备的生物敷料具有生物相容性高，敷料自身即具有抑菌、止血、促进伤口愈合的活性，还可以缓慢释放所负载的止痛剂、止血剂、抑菌剂、抗炎剂，从而可长时间发挥药效，避免频繁更换生物敷料导致的伤口刺激、伤口感染，有利于伤口的愈合。
使用本发明经流涎法制备的多用途膜易揭材料制备的胶囊壳，不仅具有机械强度高、不易破碎、不吸水、抑菌、保存期长、生物相容性高、且胶囊壳易于被机体吸收的优点，还能缓慢释放所负载的药物，而无需使用额外的缓释材料和处理方法，简化了药物的制备方法。
具体实施方式
在下文中更详细地描述了本发明以有助于对本发明的理解。
实施例1：一种经流涎法制备的多用途膜易揭材料
脱内毒素I型胶原蛋白25份、壳聚糖4份、乙基纤维素4份、聚乙烯醇2.5份、甲基丙烯酸酐1.5份、戊二醛1.5份、甘油4份，按照以下步骤制备：
(1)备料：按配方称取各原料；
(2)溶解：将配方量的胶原蛋白、壳聚糖、纤维素及其衍生物、聚乙烯醇添加至2％醋酸溶液中，在30℃条件下下搅拌直至完全溶解，其中胶原蛋白的固含量为2％；
(3)交联：在步骤(2)所得的溶液中添加甲基丙烯酸酐搅拌均匀后，边搅拌边缓慢加入交联剂戊二醛，交联剂添加完成后继续搅拌2h，过滤后添加甘油，静置消泡；
(4)制膜：将步骤(3)所得消泡后的溶液于玻璃板制备成所需厚度的膜，干燥后即得。
实施例2：一种经流涎法制备的多用途膜易揭材料
脱内毒素I型胶原蛋白20份、壳聚糖5份、乙基纤维素4份、聚乙烯醇3份、甲基丙烯酸酐2份、戊二醛1份、甘油3份，按照实施例1方法制备即得。
实施例3：一种经流涎法制备的多用途膜易揭材料
脱内毒素I型胶原蛋白30份、壳聚糖4份、乙基纤维素3份、聚乙烯醇2份、甲基丙烯酸酐2份、戊二醛2份、甘油5份，按照实施例1方法制备即得。
对比例1：一种壳聚糖改性胶原蛋白膜
脱内毒素I型胶原蛋白25份、壳聚糖8份、戊二醛1.5份、甘油4份，按照实施例1方法制备得到。
对比例2：一种改性胶原蛋白膜
脱内毒素I型胶原蛋白25份、壳聚糖4份、聚乙烯醇2.5份、戊二醛1.5份、甘油4份，按照实施例1方法制备得到。
对比例3：一种改性胶原蛋白膜
脱内毒素I型胶原蛋白25份、壳聚糖4份、聚乙烯醇、甲基丙烯酸酐1.5份、戊二醛1.5份、甘油4份，按照实施例1方法制备得到。
对比例4：脱内毒素I型胶原蛋白25份、甘油4份，按照实施例1方法制备得到。
效果例1：抑菌效果实验
1.1实验物质
实施例1-3、对比例1-4所得胶原蛋白膜。
1.2实验方法
将实验用膜在无菌条件下使用灭菌剪刀剪成3×3cm的样品，置于灭菌培养皿中，每份样品滴加灭菌PBS溶液至全部样品被浸润，置于培养箱中培养5天，每份实验用膜平行5份，记录每份样品的菌落数，实验结果见表1。
1.3实验结果
应用统计软件SPSS的多因素方差分析模块进行数据分析，P＜0.05表示差异有统计学意义。
表1本发明流涎法制备的多用途膜易揭材料抑菌效果
组别 样本量 菌落数(个)
实施例1 5 0.60±0.55＊＊
实施例2 5 0.80±0.84＊＊
实施例3 5 1.00±0.71＊＊
对比例1 5 1.60±1.14＊＊
对比例2 5 1.60±0.89＊＊
对比例3 5 1.20±0.84＊＊
对比例4 5 6.00±2.24
＊＊，与对比例4比较，P＜0.01.
表1实验结果显示了相对于仅含胶原蛋白和甘油的对比例4所得胶原蛋白膜，对比例1-3所得胶原蛋白膜均显示了优异的抑菌效果，而本发明实施例1-3所得多用途膜易揭材料抑菌效果均优于对比例1-3所得的胶原蛋白膜，显示了优异的抑菌效果。
效果例2：拉伸强度测试
2.1实验物质
实施例1-3、对比例1-4所得胶原蛋白膜。
2.2实验方法
取厚度相同的实施例1-3、对比例1-4所得胶原蛋白膜裁剪成2cm×8cm后，使用拉伸试验仪测定各胶原蛋白膜的拉伸强度，每份样品平行5份，实验结果见表2。
2.3实验结果
应用统计软件SPSS的多因素方差分析模块进行数据分析，P＜0.05表示差异有统计学意义。
表2本发明流涎法制备的多用途膜易揭材料的拉伸强度
组别 样本量 拉伸强度(MPa)
实施例1 5 4.41±0.26**
实施例2 5 3.83±0.26**
实施例3 5 3.94±0.22**
对比例1 5 1.14±0.12*
对比例2 5 1.44±0.15*
对比例3 5 1.62±0.10
对比例4 5 0.83±0.07
＊，与对比例4比较，P＜0.05；＊＊，与对比例4比较，P＜0.01.
表2实验结果显示了仅含胶原蛋白的对比例4胶原蛋白膜的拉伸强度性能最弱，表明仅含胶原蛋白的胶原蛋白膜拉伸强度差，对比例1-3组胶原蛋白膜添加壳聚糖、聚乙烯醇、甲基丙烯酸酐后拉伸强度获得改善，而本发明使用乙基纤维素、壳聚糖、聚乙烯醇、甲基丙烯酸酐改性的多用途膜易揭材料拉伸强度则获得更加明显的改善，从而扩大了多用途膜易揭材料的使用范围。
效果例3：释放效果测试
3.1实验物质
实施例1-3、对比例1-4所得胶原蛋白膜，茶碱(作为模型药物)，其中取实施例1-3、对比例1-4所得胶原蛋白膜，裁剪成3cm×3cm，每片均负载茶碱20mg。
3.2实验方法
标准曲线的制备：
精密称定茶碱20mg，置100mL量瓶中，加入纯净水，溶解后定溶。精密吸取此溶液10mL，置50mL量瓶中，加纯净水定溶，然后将此溶液以纯净水，制成0.8、2、4、8、12、16μg/mL的溶液，按照分光光度法在270nm处测定吸光度，对溶液浓度和吸光度进行回归分析得标准曲线回归方程。
释放度测试：
释放介质：纯净水900mL；
温度：37±0.5℃；
转篮速度：20r/min；
测定样品中茶碱在10min、20min、30min、60min、120min的释放度，实验结果见表3。
3.3实验结果
应用统计软件SPSS的多因素方差分析模块进行数据分析，P＜0.05表示差异有统计学意义。
表3本发明流涎法制备的多用途膜易揭材料的释放度
表3实验结果显示，对比例1-4中负载于胶原蛋白膜中的茶碱被快速释放于释放介质中，30min内基本已完全释放，而本发明实施例1-3所得流涎法制备的多用途膜易揭材料对茶碱的释放显示了明显的缓释效果，30min时仅不足50％的茶碱被释放于缓冲介质中，第120min时仅60％左右的茶碱被释放，从而表明本发明的流涎法制备的多用途膜易揭材料对于负载的活性物质具有显著的缓释效果，可明显延长药效时间，减少服药次数，提升患者依从性，避免药物突释造成的药物浪费及可能造成的副作用。
实施例4：一种经流涎法制备的多用途膜易揭材料制备的面膜
透明质酸钠1份、芦荟提取物1.5份、维生素E0.2份、氮酮0.1份，将实施例1制备得到的多用途膜易揭材料作为基材，负载透明质酸、芦荟提取物、维生素E、氮酮后，裁剪成面部轮廓后包装即得。
实施例5：一种经流涎法制备的多用途膜易揭材料制备的生物敷料
利多卡因0.5-1.5份、氢化可的松0.5-1.5份、庆大霉素0.5-1.5份，将实施例1制备得到的多用途膜易揭材料作为基材，负载利多卡因、氢化可的松、庆大霉素后附着于衬垫后包装，即得。
实施例6：一种经流涎法制备的多用途膜易揭材料制备的胶囊壳
将实施例1制备得到的多用途膜易揭材料固定于吸塑成型机加热软化后，使用吸塑模具制得硬胶囊壳。
以上描述了本发明优选实施方式，然其并非用以限定本发明。本领域技术人员对在此公开的实施方案可进行并不偏离本发明范畴和精神的改进和变化。

Claims (10)

1.一种流涎法制备的多用途膜易揭材料，其特征在于，由胶原蛋白20-30份、壳聚糖3-5份、纤维素及其衍生物3-5份、聚乙烯醇2-3份、甲基丙烯酸酐1-2份、交联剂1-2份、增塑剂3-5份，经流涎法制成。
2.根据权利要求1所述的流涎法制备的多用途膜易揭材料，其特征在于，所述胶原蛋白为脱内毒素I型胶原蛋白，所述纤维素为乙基纤维素，所述交联剂为戊二醛，所述增塑剂选自：甘油、丙二醇、甘露糖醇、山梨糖醇木糖醇、麦芽糖醇液体石蜡、甲酰胺中的一种或多种。
3.权利要求1-2任一项所述流涎法制备的多用途膜易揭材料制备面膜的用途。
4.权利要求1-2任一项所述的流涎法制备的多用途膜易揭材料制备得到的面膜，其特征在于，流涎法制备的多用途膜易揭材料用作面膜基材。
5.根据权利要求4所述的面膜，其特征在于，流涎法制备的多用途膜易揭材料中还负载有补水保湿剂、美白剂、抗氧化剂、促渗剂等的一种或多种。
6.权利要求1-2任一项所述流涎法制备的多用途膜易揭材料制备生物敷料中的用途，其特征在于，流涎法制备的多用途膜易揭材料用作生物敷料基材。
7.权利要求1-2任一项所述的流涎法制备的多用途膜易揭材料制备得到的生物敷料，其特征在于，流涎法制备的多用途膜易揭材料用作生物敷料基材，并负载有药物。
8.权利要求1-2任一项所述的流涎法制备的多用途膜易揭材料制备硬胶囊壳的用途。
9.权利要求1-2任一项所述的流涎法制备的多用途膜易揭材料制备得到的硬胶囊壳。
10.权利要求1-2任一项所述的流涎法制备的多用途膜易揭材料的制备方法，其特征在于，包括以下步骤：
(1)备料：按配方称取各原料；
(2)溶解：将配方量的胶原蛋白、壳聚糖、纤维素及其衍生物、聚乙烯醇添加至稀酸溶液中，在20-40℃条件下下搅拌直至完全溶解，其中胶原蛋白的固含量为0.5％-5％；
(3)交联：在步骤(2)所得的溶液中添加甲基丙烯酸酐搅拌均匀后，边搅拌边缓慢加入交联剂，交联剂添加完成后继续搅拌1-2h，过滤后添加增塑剂，静置消泡；
(4)制膜：将步骤(3)所得消泡后的溶液于玻璃板制备成所需厚度的膜，干燥后即得。
CN201910183522.2A 2019-03-12 2019-03-12 一种流涎法制备的多用途膜易揭材料及其应用 Pending CN110079098A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910183522.2A CN110079098A (zh) 2019-03-12 2019-03-12 一种流涎法制备的多用途膜易揭材料及其应用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910183522.2A CN110079098A (zh) 2019-03-12 2019-03-12 一种流涎法制备的多用途膜易揭材料及其应用

Publications (1)

Publication Number Publication Date
CN110079098A true CN110079098A (zh) 2019-08-02

Family

ID=67413158

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910183522.2A Pending CN110079098A (zh) 2019-03-12 2019-03-12 一种流涎法制备的多用途膜易揭材料及其应用

Country Status (1)

Country Link
CN (1) CN110079098A (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014081391A1 (en) * 2012-11-23 2014-05-30 Nanyang Technological University New photoactive bioadhesive compositions
CN104436283A (zh) * 2014-11-10 2015-03-25 苏州蔻美新材料有限公司 一种医用胶原膜材料及其制备方法
CN105936671A (zh) * 2016-06-06 2016-09-14 陕西科技大学 一种乙烯基胶原蛋白的制备方法
CN108014366A (zh) * 2017-12-15 2018-05-11 青岛海洋生物医药研究院 一种海洋生物材料复合水凝胶敷料及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014081391A1 (en) * 2012-11-23 2014-05-30 Nanyang Technological University New photoactive bioadhesive compositions
CN104436283A (zh) * 2014-11-10 2015-03-25 苏州蔻美新材料有限公司 一种医用胶原膜材料及其制备方法
CN105936671A (zh) * 2016-06-06 2016-09-14 陕西科技大学 一种乙烯基胶原蛋白的制备方法
CN108014366A (zh) * 2017-12-15 2018-05-11 青岛海洋生物医药研究院 一种海洋生物材料复合水凝胶敷料及其制备方法

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
EGE, DUYGU 等: "Graphene Oxide/Polymer-Based Biomaterials", 《ADVANCED ENGINEERING MATERIALS》 *
何领好 等: "《功能高分子材料》", 31 August 2016, 华中科技大学出版社 *
刘俊 等: "《可食性包装材料质量检验》", 30 April 2017, 中国质检出版社 *
吴旖: "《药物制剂生产》", 30 June 2015, 广东高等教育出版社 *
张鉴 等: "《中药制剂技术与设备》", 30 September 2009 *
王文生 等: "《果品蔬菜保鲜包装应用技术》", 31 January 2008, 印刷工业出版社 *
王正国: "《创伤愈合与组织修复》", 31 December 1998, 山东科学技术出版社 *
郑俊民: "《药用高分子材料学》", 30 August 2004, 中国医药科技出版社 *
顾其胜 等: "《实用生物医用材料学》", 30 September 2005, 上海科学技术出版社 *

Similar Documents

Publication Publication Date Title
Sionkowska et al. Modification of collagen and chitosan mixtures by the addition of tannic acid
Balaji et al. Preparation and comparative characterization of keratin–chitosan and keratin–gelatin composite scaffolds for tissue engineering applications
Liu et al. Alginate/gelatin‐based hydrogel with soy protein/peptide powder for 3D printing tissue‐engineering scaffolds to promote angiogenesis
CN110087459A (zh) 对在包含纳米原纤纤维素的水凝胶中的细胞进行冷冻干燥的方法以及在包含纳米原纤纤维素的气凝胶中的冷冻干燥的细胞
Liu et al. Preparation of gelatin/poly (γ-glutamic acid) hydrogels with stimulated response by hot-pressing preassembly and radiation crosslinking
CN108744025A (zh) 一种用于促进伤口愈合的抗氧化性能水凝胶及其制备方法和应用
CN104434791B (zh) 一种改性白芨多糖衍生物纳米载体的制备及应用技术
CN105407924B (zh) 包含胶原和透明质酸钠的药物组合物
Agostino et al. Semi-interpenetrated hydrogels composed of PVA and hyaluronan or chondroitin sulphate: chemico-physical and biological characterization
CN114524950B (zh) 一种疏水药物载体水凝胶及其制备方法和应用
CN108744057A (zh) 一种可注射复合凝胶及其制备方法和应用
Wei et al. Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair
CN108113977B (zh) 一种红细胞膜包封的明胶载盐酸小檗碱纳米粒的制备方法及其应用
Hou et al. Co-assembling of natural drug-food homologous molecule into composite hydrogel for accelerating diabetic wound healing
CN115887772A (zh) 一种明胶/海藻酸钠水凝胶基3d打印生物墨水及其应用
CN103525097A (zh) 一种水产鱼皮明胶海绵及其制备方法
Liu et al. Citric acid cross‐linked chitosan for inhibiting oxidative stress after nerve injury
An et al. Role of chlorogenic acid and procyanidin in the modification of self-assembled fibrillar gel prepared from tilapia collagen
Chen et al. Mussel-inspired self-healing hydrogel form pectin and cellulose for hemostasis and diabetic wound repairing
Wang et al. Effects of proanthocyanidins and dialdehyde chitosan on the proliferation and differentiation of bovine myoblast for cultured meat production
Song et al. Oxidized cyclodextrin inclusion tea tree oil to prepare long‐lasting antibacterial collagen scaffold for enhanced wound healing
CN103819685A (zh) 鱼鳞胶原蛋白接枝壳聚糖及其制备方法、用途
Zhu et al. Guanidinylated/PEGylated chitosan in the bioink promotes the formation of multi-layered keratinocytes in a human skin equivalent
CN104983710B (zh) 一种植物胶囊剂的制备方法
CN105820267B (zh) 一种皮肤创面修复制剂及其制备方法和应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20190802