CN110075186A - A kind of preparation method and purposes of compound Rehmannia glutinosa combined extracts - Google Patents
A kind of preparation method and purposes of compound Rehmannia glutinosa combined extracts Download PDFInfo
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- CN110075186A CN110075186A CN201910407844.0A CN201910407844A CN110075186A CN 110075186 A CN110075186 A CN 110075186A CN 201910407844 A CN201910407844 A CN 201910407844A CN 110075186 A CN110075186 A CN 110075186A
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Abstract
The invention discloses the preparation methods and purposes of a kind of compound Rehmannia glutinosa combined extracts.Method of the invention is made by the Chinese medicine material Rehmannia glutinosa 9-15 of following parts by weight, prepared fleece flower root 6-12, fructus lycii 6-12, deer horn glue 3-6, colla carapacis et plastri testudinis 3-9, Semen Cuscutae 6-12 and with the cyclodextrin of the parts by weight such as Chinese medicine material, and water mill that weight is 1:1 first is added into paste in Rehmannia glutinosa；The fleece-flower root, fructus lycii are dried in advance, 24 mesh powder is ground into, Semen Cuscutae is pulverized；The medicinal material handled well is mixed, weight ratio is added is the alcohol that 1:3 content is 96%, soaking, filters pressing, recovered alcohol, low temperature are condensed into thick paste, filter residue is separately separately added into the water that crude drug weight ratio is 1:8 and 1:5 and carries out secondary decoction, the secondary decoction liquor of leaching is concentrated at thick paste, the above-mentioned thick paste of gained twice is merged, it will be sequentially added after deer horn glue and colla carapacis et plastri testudinis respectively molten again, add the cyclodextrin of formula ratio, it is ground, dry, be sieved to obtain the final product.Product of the present invention is as the purposes for being prepared into functional food or wine product.
Description
Technical field
The present invention relates to Chinese medicine manufacture fields, while being related to field of functional food, and in particular to a kind of compound Rehmannia glutinosa
The preparation method and purposes of combined extracts.
Background technique
With the rapid raising of China's socio-economic development level, it is some in the past not that the people has begun attention change
Too reasonable eating habit, " science eaten, health living, living is permanent " have become the generally pursuit of people.National income
Increase and the level of consumption raising, and people is made to have stronger consuming capacity, it is sufficient to pay wholesome functional food
Condition is to higher spending.It is all these all to constitute the very strong driving force of current functional food Industry Quick Development.With society
Fast development that can be economic, people's lives tempo increase, life stress is big, and many unsound factors such as stay up late cause liver kidney
Deficiency, pale complexion or sallow caused by blood and essence asthenia, dizziness, insomnia, palpitaition, amnesia, be in a trance, eyes it is dim-sighted, beard and hair
The deficiency of blood symptom such as early white.According to the theory of " essence and blood sharing the same origin ", Rehmannia glutinosa not only can be with nourishing the blood and yin, moreover it is possible to supplying vital essence and marrow.Essence and blood
Virtual loss can often cause slow, slow in reacting, the adult early ageing of development in children, amnesia, be in a trance, eyes is dim-sighted, poliosis, male
The symptoms such as subfunction decline.It is mended for above-mentioned symptom compatible use prepared fleece flower root, fructus lycii, deer horn glue, colla carapacis et plastri testudinis, Semen Cuscutae etc.
The Chinese medicine of blood strengthening the essence effectively can play conditioning effect to above-mentioned all symptoms.In order to make a kind of compound Rehmannia glutinosa of the present invention
Pharmaceutical composition plays better application effect, can there is a good eating method to it, reaches using convenient, dosage is accurate,
Preparing a kind of compound Rehmannia glutinosa combined extracts can not only achieve the purpose that it is accurately applied, while be also used as functionality
Formulation products needed for food preparation.
With regard to the present invention a kind of preparation method and purposes of compound Rehmannia glutinosa combined extracts, through retrieving, there is not yet related
Report and related patent application.
Summary of the invention
The object of the present invention is to provide a kind of preparation methods of compound Rehmannia glutinosa combined extracts.
The present invention also aims to provide a kind of compound Rehmannia glutinosa combined extracts as being prepared into functional food or wine
The purposes of product.
The preparation method of a kind of compound Rehmannia glutinosa combined extracts provided by the invention, which is characterized in that it is by following
Chinese medicine material Rehmannia glutinosa 9-15, prepared fleece flower root 6-12, fructus lycii 6-12, deer horn glue 3-6, the colla carapacis et plastri testudinis 3-9, Semen Cuscutae of parts by weight
It 6-12 and is made with the cyclodextrin of the parts by weight such as Chinese medicine material,
Specifically the production method is as follows: (1) weigh Rehmannia glutinosa and cut into particle, the water that Rehmannia glutinosa weight ratio is 1:1 is added and is ground into
Paste, it is spare；Weigh prepared fleece flower root, fructus lycii is first dried, it is spare to be then comminuted into 24 mesh powder, weigh Semen Cuscutae pulverize it is standby
With；(2) being pulverized and mixed paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae and medicinal material total weight ratio is added is 1:3
Concentration is the alcohol of 96%v/v, stirs evenly, soak at room temperature 12 days, is sufficiently stirred daily during immersion 1 time, after immersion,
Filters pressing is carried out, collects alcohol soak, filter residue is spare；(3) by alcohol soak obtained by step (2), simultaneously low temperature is dense for recovered alcohol
It is spare to shorten thick paste into；(4) water that crude drug weight ratio is 1:8 is added in the filter residue in step (2), heating is boiled 2 hours, is filtered
Decoction liquor is taken, filter residue adds the water that crude drug weight ratio is 1:5, and heating is boiled 1.5 hours, and leaching decoction liquor discards filter
Slag；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, it is concentrated spare at thick paste；(6) by step (3) and step
Suddenly (2) gained thick paste mixing respectively, then will be added sequentially to mix in thick do after deer horn glue and colla carapacis et plastri testudinis respectively molten, sufficiently grind
It is even, the cyclodextrin of the parts by weight such as medicinal material is added, is placed in and carries out being fully ground 3 hours, after grinding in ball mill, extract
Material is 5-6%w/w through drying to water content, pulverizes, and crosses 80 meshes to get compound Rehmannia glutinosa combined extracts.
Present invention cyclodextrin (CYD) described above, can be beta-cyclodextrin, be also possible to 2,6- dimethyl-β-ring paste
Smart (DM- β -- CYD), hydroxyethyl-β-cyclodextrin (HE- β-CYD), hydroxypropyl-β-cyclodextrin (HP- β-CYD) and sulfobutyl ether-
Any one in beta-cyclodextrin (SBE- β-CYD).
CYD is safe and non-toxic, pertinent regulations (the FAQ nutrition meeting according to the World Health Organization to food additives
NO46WHO/FOOD ADD/70.36), the starch of enzymology feature no longer needs to do toxicity research；Many experimental studies also turn out β-
CYD tool shows its LD of Mouse oral in very high safety, acute toxicity test50> 300 mg/kg, acute toxicity and chronic toxicity
Test, carcinogenic, mutagenicity test of teratogenesis etc. demonstrate this product using safe and non-toxic.The U.S., Japan pharmacopeia oneself B-CYD is recorded
To take orally auxiliary material: HP-B-CYD(hydroxypropyl-B- cyclodextrin) " the Handboofk of that has been write by United States Pharmacopeia and Wade A
Pharrnaceutical Excipients " record for injection supplementary material (Zhao Jie is such as edited, modern Chinese herbal medicine new agent technology,
Jiangsu science tech publishing house, 2 months 2007 the 1st edition, page 151).
Heretofore described alcohol is referred both to when not making certain illustrated as food grade alcohol.
Heretofore described water is pure water when not making certain illustrated.
The temperature condition of present invention low temperature concentration described above is 50 DEG C -60 DEG C.
Present invention drying described above is using vacuum drying, and vacuum drying condition is temperature 50 C, vacuum degree
For 0.2kPa.
Compound Rehmannia glutinosa combined extracts of the present invention, routinely granule, tablet, capsule, ball is made in technique
Agent, syrup or oral solution are as the purposes for preparing functional food.
Heretofore described compound Rehmannia glutinosa combined extracts are as the purposes for preparing wine product.
The preparation method of currently preferred a kind of compound Rehmannia glutinosa combined extracts, it is characterized in that by following parts by weight
Chinese medicine material Rehmannia glutinosa 11-13, prepared fleece flower root 8-10, fructus lycii 7-11, deer horn glue 4-6, colla carapacis et plastri testudinis 5-7, Semen Cuscutae 8-10 and
It is made with the cyclodextrin of the parts by weight such as Chinese medicine material,
Specifically the production method is as follows: (1) weigh Rehmannia glutinosa and cut into particle, the water that Rehmannia glutinosa weight ratio is 1:1 is added and is ground into
Paste, it is spare；Weigh prepared fleece flower root, fructus lycii is first dried, it is spare to be then comminuted into 24 mesh powder, weigh Semen Cuscutae pulverize it is standby
With；(2) being pulverized and mixed paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae and medicinal material total weight ratio is added is 1:3
Concentration is the alcohol of 96%v/v, stirs evenly, soak at room temperature 12 days, is sufficiently stirred daily during immersion 1 time, after immersion,
Filters pressing is carried out, collects alcohol soak, filter residue is spare；(3) by alcohol soak obtained by step (2), simultaneously low temperature is dense for recovered alcohol
It is spare to shorten thick paste into；(4) water that crude drug weight ratio is 1:8 is added in the filter residue in step (2), heating is boiled 2 hours, is filtered
Decoction liquor is taken, filter residue adds the water that crude drug weight ratio is 1:5, and heating is boiled 1.5 hours, and leaching decoction liquor discards filter
Slag；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, it is concentrated spare at thick paste；(6) by step (3) and step
Suddenly (2) gained thick paste mixing respectively, then will be added sequentially to mix in thick do after deer horn glue and colla carapacis et plastri testudinis respectively molten, sufficiently grind
It is even, the cyclodextrin of the parts by weight such as medicinal material is added, is placed in and carries out being fully ground 3 hours, after grinding in ball mill, extract
Material is 5-6%w/w through drying to water content, pulverizes, and crosses 80 meshes to get compound Rehmannia glutinosa combined extracts.
The preparation method of the further preferred a kind of compound Rehmannia glutinosa combined extracts of the present invention, it is characterized in that by following heavy
Measure the Chinese medicine material Rehmannia glutinosa 12, prepared fleece flower root 9, fructus lycii 9, deer horn glue 5, colla carapacis et plastri testudinis 6, Semen Cuscutae 9 and and Chinese medicine material of part
Etc. the cyclodextrin of parts by weight be made,
Specifically the production method is as follows: (1) weigh Rehmannia glutinosa and cut into particle, the water that Rehmannia glutinosa weight ratio is 1:1 is added and is ground into
Paste, it is spare；Weigh prepared fleece flower root, fructus lycii is first dried, it is spare to be then comminuted into 24 mesh powder, weigh Semen Cuscutae pulverize it is standby
With；(2) being pulverized and mixed paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae and medicinal material total weight ratio is added is 1:3
Concentration is the alcohol of 96%v/v, stirs evenly, soak at room temperature 12 days, is sufficiently stirred daily during immersion 1 time, after immersion,
Filters pressing is carried out, collects alcohol soak, filter residue is spare；(3) by alcohol soak obtained by step (2), simultaneously low temperature is dense for recovered alcohol
It is spare to shorten thick paste into；(4) water that crude drug weight ratio is 1:8 is added in the filter residue in step (2), heating is boiled 2 hours, is filtered
Decoction liquor is taken, filter residue adds the water that crude drug weight ratio is 1:5, and heating is boiled 1.5 hours, and leaching decoction liquor discards filter
Slag；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, it is concentrated spare at thick paste；(6) by step (3) and step
Suddenly (2) gained thick paste mixing respectively, then will be added sequentially to mix in thick do after deer horn glue and colla carapacis et plastri testudinis respectively molten, sufficiently grind
It is even, the cyclodextrin of the parts by weight such as medicinal material is added, is placed in and carries out being fully ground 3 hours, after grinding in ball mill, extract
Material is 5-6%w/w through drying to water content, pulverizes, and crosses 80 meshes to get compound Rehmannia glutinosa combined extracts.
Heretofore described molten is that well known plus water molten method is produced.
Rehmannia glutinosa is the dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Liboscn., is added through processing
Work is made.
Rehmannia glutinosa nature and flavor are sweet, tepor.Return liver and kidney channel.Have enriching yin of enriching blood, beneficial to spirit and marrow.For blood deficiency chlorosis, palpitaition is seized with terror
It is secondary, irregular menstruation, metrostaxis, the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat spermatorrhea, Heat Diabetes, dizziness, tinnitus,
Poliosis.
Utility analysis: the sweet tepor of Rehmannia glutinosa enters liver kidney channel, and quality is soft and moist.Blood stored in the liver, kidney storing essence, essence and blood sharing the same origin, Rehmannia glutinosa
It is longer than promoting vital essence and blood genernation, can be with all cards of the deficiency of blood symptoms include sallow complexion to be controlled for key medicine of enriching blood, palpitaition is seized with terror secondary, dizziness, tinnitus etc..
Rehmannia glutinosa enters kidney, and matter profit taste is greasy, has the benefits of fabulous nourishing kidney yin, is usually used in the soreness and weakness of waist and knees of the deficiency of the kidney yin, bone
Steam hectic fever, night sweat spermatorrhea, Heat Diabetes.
Rehmannia glutinosa is enriched blood enriching yin, beneficial to spirit and marrow, therefore still with controlling kidney deficiency and liver, the dizziness of blood and essence asthenia, tinnitus, beard and hair morning
It is white.
Prepared fleece flower root is the dried root of trailing plants section Plant-Polygonum Polygonum multiflorum Thunb. through processing
It processes and obtains.
Prepared fleece flower root is bitter in taste, sweet, puckery, tepor.Return liver, the heart, kidney channel.Prepared fleece flower root has nourishing liver and kidney, benefiting essence-blood, black palpus
Turbid lipid-reducing function is changed in hair, strengthening the bones and muscles.For blood deficiency chlorosis, dizziness and tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, metrorrhagia and metrostaxis
Leukorrhagia, hyperlipidemia.
Utility analysis: prepared fleece flower root is longer than nourishing liver and kidney, benefiting essence-blood, and tepor is not dry, mend and it is oiliness, actually nourishing it is good
Medicine is common to control blood deficiency chlorosis.
Prepared fleece flower root main benefit sweet in flavor is longer than tonifying liver blood, kidney-nourishing essence, strengthening the bones and muscles.The institute of hair is the sign of blood condition, kidney is flourish, and essence and blood obtains
It fills, is then apt to black beard and hair；And puckery and vital essence can be restrained, and hardship lets out tepor, not cold not dry, it may also be used for kidney deficiency and liver, blood and essence asthenia,
Dizziness and tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, the inferior card of metrorrhagia and metrostaxis band.
Prepared fleece flower root can also change turbid lipid-loweringing, be used for hyperlipidemia.
The fleece-flower root matches Rehmannia glutinosa, and the fleece-flower root is longer than nourishing liver and kidney, benefiting essence-blood, black beard and hair, mends and oiliness；Rehmannia glutinosa is good at enriching blood
Enriching yin, life essence-filling, marrow-benefitting, flavour are mellow.Two medicines 5 are used, and nourishing yin and nourishing blood can be enhanced, and the function of enriching essence and nourishing marrow is suitable for kidney deficiency and liver, essence
Sallow complexion caused by anemia is empty, dizziness and tinnitus, soreness and weakness of waist and knees, poliosis, spermatorrhea, the slow person's (National Pharmacopeia of development in children
Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs volume, version in 2015,1205-1206 compile in the committee
Page).
Fructus lycii is the dry mature fruit of Lycium barbarum L. of solanaceae Lycium barbarum L..
Fructus lycii nature and flavor sweet and neutral.Return liver and kidney channel.Has nourishing liver and kidney, benefiting shrewd head function.For consumption consumptive loss, waist and knee acid
Bitterly, dizziness and tinnitus, impotence and seminal emission, Heat Diabetes, blood deficiency chlorosis, dusk day are unknown.
Utility analysis: fructus lycii is sweet in flavor mild-natured, enters liver kidney channel, is longer than nourshing kidney essence, tonifying liver blood, " Bencao Jingshu " says it: " for
Liver kidney kidney-KIN being deficient, the tired interior key medicine for vulcanizing benefit ", slides soreness and weakness of waist and knees caused by liver kidney blood and essence asthenia, dizziness and tinnitus, spermatorrhea
Smart, infertile, blurred vision etc. can apply.Fructus lycii energy benefiting essence-blood, " tranquilizing the mind " (" haigoushen "), can be used for deficiency of blood complexion
Sallow, palpitaition is out of strength；Puerperal exposure to wind consumptive disease damage, limbs pain, mind dysphoria, loss of appetite；Hematasthenic cough, night sweat spontaneous perspiration, hectic fever due to yin
Hectic fever, it is dysphoria in chestpalms-soles；Internal lesion caused by overexertion is deficient, and four limbs are thin thin out of strength；Married woman's postpartum deficient qi and blood, (the National Pharmacopeia committee member such as oligogalactia
Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs volume, version in 2015, page 1230 can be compiled).
Collective Notes to the Canon of Materia medica " nourishing the essence and strengthening QI, prosperous and powerful vagina." " haigoushen " " energy help essence various symptims and signs of deficiency, Yi Yanse bleach,
Improving eyesight calms the nerves, makes us long-lived."
This product have enhancing immune, anti-agings, sex hormone sample, anti-liver injury, hypoglycemic, improvement retinopathy, Adjust-blood lipid,
(Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs are compiled by Chinese Pharmacopoeia Commission for antifatigue equal pharmacological actions
Volume, version in 2015, page 1232).
Deer horn glue is animal in deer family sika deer Ceruus nippon Temminck or red deer Ceruus elaph-
Usliinnaeus. blob of viscose made of angle decocts.
Deer horn glue nature and flavor are sweet, salty, and temperature returns liver, kidney channel.Has help essence and blood, miscarriage prevention hemostatic function is suitable for kidney deficiency, essence and blood
Deficiency, consumptive disease is thin tired, dizziness and tinnitus, soreness and weakness of waist and knees, impotence involuntary emission, fertility, threatened abortion, metrorrhagia and metrostaxis leukorrhagia, spits blood, nosebleed
Blood, hematuria, negative subcutaneous ulcer sore (Wang Guoqiang edits " national Chinese herbal medicine " (volume four), People's Health Publisher, 2 months 2014 the 3rd edition,
117-118 editions).
Colla carapacis et plastri testudinis is the glue that Testudinidae animal tortoise Chinemys reevesii (Gray) plastron is brewed into.
Colla carapacis et plastri testudinis nature and flavor are sweet, micro- salty, put down.Return liver, kidney, the heart channel of Hang-Shaoyin.With enriching yin, blood-nourishing, hemostatic function.Suitable for deficiency of Yin tide
Heat, hectic fever due to yin night sweat, soreness and weakness of waist and knees, blood deficiency chlorosis, metrorrhagia and metrostaxis leukorrhagia.
Have Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs volume, 1243-1245 pages of version in 2015
It introduces: colla carapacis et plastri testudinis and tortoise plastron, the two nature and flavor, channel tropism, function and curing mainly similar, but the colla carapacis et plastri testudinis efficacy of a drug is compared with Qiang Ershan nourishing yin and nourishing blood
Hemostasis.It is used with Rehmannia glutinosa 5, enriching yin and nourishing kidney, the effect of strengthening the muscles and bones can be enhanced.
Semen Cuscutae is convolvulaceous plant Cuscuta australis Cuscuta australis R.Br. or Semen Cuscutae Cus-cuta
The dry mature seed of chinensis Lam..
Semen Cuscutae nature and flavor are pungent, sweet and neutral.Liver,kidney,spleen is returned to pass through.Tool tonifies the liver and kidney, astringent sperm contracting urine, miscarriage prevention, improving eyesight, antidiarrheal function
Energy.For kidney deficiency and liver, soreness and weakness of waist and knees, impotence and seminal emission, enuresis frequent micturition, vaginal bleeding due to deficiency of the kidney during pregnancy, blurred vision tinnitus, spleen kidney deficiency rushes down.
Utility analysis: Semen Cuscutae Xin Ganping enters liver kidney the spleen channel, Xin Nengrun, sweet to mend, it is mild-natured and, not only kidney-replenishing, but also mend
Kidney yin, for the product that yin-yang is all mended, function tonifies the liver and kidney, and astringent sperm contracting urine is used for kidney deficiency and liver, soreness and weakness of waist and knees, impotence and seminal emission, the enuresis
Frequent micturition.
Semen Cuscutae has kidney-nourishing nourishing the liver again, makes to infuse on essence and blood and have the benefits of improving eyesight, clever ear, therefore can be used and control caused by kidney deficiency and liver
Blurred vision tinnitus.Semen Cuscutae energy invigorating the kidney and spleen and only void is rushed down, be usually used in the diarrhea loose stool of the insufficiency of both the spleen and the kindey.
Semen Cuscutae matches Rehmannia glutinosa, and Semen Cuscutae is longer than tonifying kidney and benefiting sperm；Rehmannia glutinosa is good at nourishing yin and nourishing blood, beneficial to spirit and marrow.Two medicines 5
With the function of enhancing tonifying kidney and benefiting sperm.Suitable for impotence and seminal emission caused by damage of kidney-essence, waist soreness, dizziness and tinnitus, blurring of vision etc.
(Chinese Pharmacopoeia Commission compiles the Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs and rolls up, version in 2015,
1163-1164 pages).
The preparation method of compound Rehmannia glutinosa combined extracts of the present invention plays coordination between effectively combining medicinal material
With the effect of conditioning engine body, compound Rehmannia glutinosa combined extracts are the Rehmannia glutinosa by having enrich blood enriching yin, beneficial to spirit and marrow effect, tool
There is the prepared fleece flower root of nourishing liver and kidney, benefiting essence-blood, strengthening the bones and muscles effect, with nourishing liver and kidney, benefiting shrewd head effect fructus lycii, has and mend
The deer horn glue of benefiting essence-blood effect, with enriching yin, the colla carapacis et plastri testudinis of blood-nourishing effect and with the astringent sperm contracting urine that tonifies the liver and kidney, function of improving eyesight
Semen Cuscutae composition, for the deficiency of liver-yin and kidney-yin, blood deficiency chlorosis, soreness and weakness of waist and knees, dizziness and tinnitus, the symptoms such as blurring of vision are with health-care assistance
Effect.Its medicinal material essence is extracted using modern crafts, can be conducive to take the reduction of medicinal material amount, and convenient to take, product of the present invention
It not only quantitatively can directly take, can also will can be connect in Chinese medicine group and extract and pharmacy or food from the convenience of application
The auxiliary material received is hybridly prepared into granule, tablet, capsule, pill, oral solution, syrup or wine product.Wherein tablet may be used also
With preferred effervescent tablet, chewable tablets, buccal tablet, because effervescent tablet, chewable tablets, buccal tablet have the following obvious compared with conventional tablet
Advantage: (1) convenient to take, a certain amount of sugar conduct will be added due to preparing these tablets in chewable clothes, buccal, Ke Huashui
Excipient, thus in good taste, people gladly take, and effervescent tablet adds after water self-dissolving like one glass of beverage, and people is made to be happy to drink；
(2) fast, bioavilability height is absorbed；(3) easy to carry, convenient transportation；(4) it is easy to quantify, dosage is accordingly accurate；Wherein capsule
Agent can be prepared into soft capsule and hard capsule, and wherein pill can be prepared into water pill, dripping pill, pellet and honeyed bolus.It is wherein described
Wine product existing white wine, grape wine, yellow rice wine and beer may be selected, blent, be aged common process and be prepared into white wine, grape
Wine, yellow rice wine and beer product.
Specific embodiment
It is that the present invention is further illustrated, but does not constitute any limit to the scope of the present invention by following embodiment
System.
Embodiment 1
The preparation of compound Rehmannia glutinosa combined extracts:
(1) Chinese traditional medicine composition: Rehmannia glutinosa 1.5kg, prepared fleece flower root 1.2kg, fructus lycii 1.2kg, deer horn glue 0.6kg, colla carapacis et plastri testudinis
The beta-cyclodextrin of 0.9kg, Semen Cuscutae 1.2kg and 6.6kg,
(2) preparation method: (1) weighing Rehmannia glutinosa 1.5kg and cut into particle, and the pure water that 1.5kg is added, which is set, is ground into paste in mortar
Object, it is spare；It takes prepared fleece flower root, fructus lycii first to be dried, then weighs prepared fleece flower root 1.2kg, fructus lycii 1.2kg is ground into 24
Mesh powder is spare, weigh Semen Cuscutae 1.2kg pulverize it is spare；(2) by paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae
It is pulverized and mixed, the edible alcohol 15.3kg that concentration is 96%v/v is added, stirs evenly, soak at room temperature 12 days, during immersion daily
It is sufficiently stirred 1 time, after immersion, carries out filters pressing, collect alcohol soak, filter residue is spare；(3) by alcohol obtained by step (2)
Soak recycles ethyl alcohol and to be condensed into thick paste under the conditions of 50 DEG C spare；(4) filter residue in step (2) is added 40.8kg's
Pure water, heating are boiled 2 hours, and heating is boiled 2 hours, and leaching decoction liquor, filter residue adds the pure water of 25.5kg, and heating is boiled
Boiling 1.5 hours, leaching decoction liquor discards filter residue；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, carries out dense
It is spare to shorten thick paste into；(6) thick do obtained by step (5) is mixed up into conjunction with thick obtained by step (2), then deer horn glue and colla carapacis et plastri testudinis is distinguished
It is added sequentially to mix in thick do after molten, sufficiently grind well, add the beta-cyclodextrin of 6.6kg, be placed in ball mill and filled
Points grinding 3 hours, after grinding, material is taken out, is placed in vacuum drier temperature is 50 DEG C, vacuum degree is 0.2kPa item
Being dried under part to water content is 5.5%w/w, is pulverized, and crosses 80 meshes to get compound Rehmannia glutinosa combined extracts.
Routinely technique is made granule, tablet, capsule, pill, takes orally the compound Rehmannia glutinosa combined extracts
Liquid or syrup are as the purposes for preparing functional food.
The compound Rehmannia glutinosa combined extracts are as the purposes for preparing wine product.
Embodiment 2
The preparation of compound Rehmannia glutinosa combined extracts:
(1) Chinese traditional medicine composition: Rehmannia glutinosa 1.3kg, prepared fleece flower root 0.8kg, fructus lycii 0.7kg, deer horn glue 0.4kg, colla carapacis et plastri testudinis
The hydroxypropyl-β-cyclodextrin of 0.5kg, Semen Cuscutae 0.8kg and 4.5kg,
(2) preparation method: (1) weighing Rehmannia glutinosa 1.3kg and cut into particle, and the pure water that 1.3kg is added, which is set, is ground into paste in mortar
Object, it is spare；It takes prepared fleece flower root, fructus lycii first to be dried, then weighs prepared fleece flower root 0.8kg, fructus lycii 0.7kg is ground into 24
Mesh powder is spare, weigh Semen Cuscutae 0.8kg pulverize it is spare；(2) by paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae
It is pulverized and mixed, the edible alcohol 10.8kg that concentration is 96%v/v is added, stirs evenly, soak at room temperature 12 days, during immersion daily
It is sufficiently stirred 1 time, after immersion, carries out filters pressing, collect alcohol soak, filter residue is spare；(3) by alcohol obtained by step (2)
Soak recycles ethyl alcohol and to be condensed into thick paste under the conditions of 60 DEG C spare；(4) filter residue in step (2) is added 28.8kg's
Pure water, heating are boiled 2 hours, and heating is boiled 2 hours, and leaching decoction liquor, filter residue adds the pure water of 18kg, and heating is boiled
1.5 hours, leaching decoction liquor discarded filter residue；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, is concentrated
It is spare at thick paste；(6) thick do obtained by step (5) is mixed up into conjunction with thick obtained by step (2), then deer horn glue and colla carapacis et plastri testudinis is distinguished into melt
Be added sequentially to mix in thick do after change, sufficiently grind well, add the hydroxypropyl-β-cyclodextrin of 4.5kg, be placed in ball mill into
Row is fully ground 3 hours, after grinding, takes out material, is placed in vacuum drier temperature is 50 DEG C, vacuum degree is
Being dried under the conditions of 0.2kPa to water content is 5%w/w, is pulverized, and crosses 80 meshes to get compound Rehmannia glutinosa combined extracts.
Routinely technique is made granule, tablet, capsule, pill, takes orally the compound Rehmannia glutinosa combined extracts
Liquid or syrup are as the purposes for preparing functional food.
The compound Rehmannia glutinosa combined extracts are as the purposes for preparing wine product.
Embodiment 3
The preparation of compound Rehmannia glutinosa combined extracts:
(1) Chinese traditional medicine composition: Rehmannia glutinosa 1.2kg, prepared fleece flower root 0.9kg, fructus lycii 0.9kg, deer horn glue 0.5kg, colla carapacis et plastri testudinis
The hydroxyethyl-β-cyclodextrin of 0.6kg, Semen Cuscutae 0.9kg and 4.1kg,
(2) preparation method: (1) weighing Rehmannia glutinosa 1.2kg and cut into particle, and the pure water that 1.2kg is added, which is set, is ground into paste in mortar
Object, it is spare；It takes prepared fleece flower root, fructus lycii first to be dried, then weighs prepared fleece flower root 0.9kg, fructus lycii 0.9kg is ground into 24
Mesh powder is spare, weigh Semen Cuscutae 0.9kg pulverize it is spare；(2) by paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae
It is pulverized and mixed, the edible alcohol 9kg that concentration is 96%v/v is added, stirs evenly, soak at room temperature 12 days, is filled daily during immersion
Divide stirring 1 time, after immersion, carries out filters pressing, collect alcohol soak, filter residue is spare；(3) alcohol obtained by step (2) is soaked
Liquid is steeped, ethyl alcohol is recycled and to be condensed into thick paste under the conditions of 50 DEG C spare；(4) the pure of 24kg is added in the filter residue in step (2)
Water, heating are boiled 2 hours, and heating is boiled 2 hours, leaching decoction liquor, and filter residue adds the pure water of 15kg, and heating boils 1.5
Hour, leaching decoction liquor discards filter residue；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, is condensed into
Thick paste is spare；(6) thick do obtained by step (5) is mixed up into conjunction with thick obtained by step (2), then deer horn glue and colla carapacis et plastri testudinis is distinguished into molten
After be added sequentially to mix in thick do, sufficiently grind well, add the hydroxyethyl-β-cyclodextrin of 4.1kg, be placed in ball mill and carry out
Be fully ground 3 hours, after grinding, take out material, be placed in vacuum drier temperature be 50 DEG C, vacuum degree 0.2kPa
Under the conditions of dry to water content be 6%w/w, pulverized, cross 80 meshes to get compound Rehmannia glutinosa combined extracts.
Routinely technique is made granule, tablet, capsule, pill, takes orally the compound Rehmannia glutinosa combined extracts
Liquid or syrup are as the purposes for preparing functional food.
The compound Rehmannia glutinosa combined extracts are as the purposes for preparing wine product.
Embodiment 4
The preparation of compound Rehmannia glutinosa combined extracts:
(1) Chinese traditional medicine composition: Rehmannia glutinosa 1.1kg, prepared fleece flower root 0.6kg, fructus lycii 0.6kg, deer horn glue 0.3kg, colla carapacis et plastri testudinis
2, the 6- dimethyl-β-cyclodextrin of 0.3kg, Semen Cuscutae 0.6kg and 3.5kg,
(2) preparation method: (1) weighing Rehmannia glutinosa 1.1kg and cut into particle, and the pure water that 1.1kg is added, which is set, is ground into paste in mortar
Object, it is spare；It takes prepared fleece flower root, fructus lycii first to be dried, then weighs prepared fleece flower root 0.6kg, fructus lycii 0.6g is ground into 24
Mesh powder is spare, weigh Semen Cuscutae 0.6kg pulverize it is spare；(2) by paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae
It is pulverized and mixed, the edible alcohol 8.7kg that concentration is 96%v/v is added, stirs evenly, soak at room temperature 12 days, during immersion daily
It is sufficiently stirred 1 time, after immersion, carries out filters pressing, collect alcohol soak, filter residue is spare；(3) by alcohol obtained by step (2)
Soak recycles ethyl alcohol and to be condensed into thick paste under the conditions of 50 DEG C spare；(4) filter residue in step (2) is added 23.2kg's
Pure water, heating are boiled 2 hours, and heating is boiled 2 hours, and leaching decoction liquor, filter residue adds the pure water of 14.5kg, and heating is boiled
Boiling 1.5 hours, leaching decoction liquor discards filter residue；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, carries out dense
It is spare to shorten thick paste into；(6) thick do obtained by step (5) is mixed up into conjunction with thick obtained by step (2), then deer horn glue and colla carapacis et plastri testudinis is distinguished
It is added sequentially to mix in thick do after molten, sufficiently grind well, add 2, the 6- dimethyl-β-cyclodextrin of 3.5kg, be placed in ball milling
It carries out being fully ground 3 hours, after grinding in machine, takes out material, being placed in vacuum drier in temperature is 50 DEG C, vacuum degree
It is 5.8%w/w to dry under the conditions of 0.2kPa to water content, is pulverized, crosses 80 meshes to get compound Rehmannia glutinosa and combine extraction
Object.
Routinely technique is made granule, tablet, capsule, pill, takes orally the compound Rehmannia glutinosa combined extracts
Liquid or syrup are as the purposes for preparing functional food.
The compound Rehmannia glutinosa combined extracts are as the purposes for preparing wine product.
Embodiment 5
The preparation of compound Rehmannia glutinosa combined extracts:
(1) Chinese traditional medicine composition: Rehmannia glutinosa 0.9kg, prepared fleece flower root 1.0kg, fructus lycii 1.1kg, deer horn glue 0.4kg, colla carapacis et plastri testudinis
The sulfobutyl ether-beta-cyclodextrin of 0.5kg, Semen Cuscutae 0.7kg and 4.6kg,
(2) preparation method: (1) weighing Rehmannia glutinosa 0.9kg and cut into particle, and the pure water that 0.9g is added, which is set, is ground into paste in mortar
Object, it is spare；It takes prepared fleece flower root, fructus lycii first to be dried, then weighs prepared fleece flower root 1.0kg, fructus lycii 1.1kg is ground into 24
Mesh powder is spare, weigh Semen Cuscutae 0.7kg pulverize it is spare；(2) by paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae
It is pulverized and mixed, the edible alcohol 11.1kg that concentration is 96%v/v is added, stirs evenly, soak at room temperature 12 days, during immersion daily
It is sufficiently stirred 1 time, after immersion, carries out filters pressing, collect alcohol soak, filter residue is spare；(3) by alcohol obtained by step (2)
Soak recycles ethyl alcohol and to be condensed into thick paste under the conditions of 50 DEG C spare；(4) filter residue in step (2) is added 29.6kg's
Pure water, heating are boiled 2 hours, and heating is boiled 2 hours, and leaching decoction liquor, filter residue adds the pure water of 18.5kg, and heating is boiled
Boiling 1.5 hours, leaching decoction liquor discards filter residue；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, carries out dense
It is spare to shorten thick paste into；(6) thick do obtained by step (5) is mixed up into conjunction with thick obtained by step (2), then deer horn glue and colla carapacis et plastri testudinis is distinguished
It is added sequentially to mix in thick do after molten, sufficiently grind well, add the sulfobutyl ether-beta-cyclodextrin of 4.6kg, be placed in ball mill
It inside carries out being fully ground 3 hours, after grinding, takes out material, be placed in vacuum drier temperature is 50 DEG C, vacuum degree is
Being dried under the conditions of 0.2kPa to water content is 5.3%w/w, is pulverized, and crosses 80 meshes to get compound Rehmannia glutinosa combined extracts.
Routinely technique is made granule, tablet, capsule, pill, takes orally the compound Rehmannia glutinosa combined extracts
Liquid or syrup are as the purposes for preparing functional food.
The compound Rehmannia glutinosa combined extracts are as the purposes for preparing wine product.
Claims (10)
1. a kind of preparation method of compound Rehmannia glutinosa combined extracts, which is characterized in that it is former by the Chinese medicine of following parts by weight
Expect Rehmannia glutinosa 9-15, prepared fleece flower root 6-12, fructus lycii 6-12, deer horn glue 3-6, colla carapacis et plastri testudinis 3-9, Semen Cuscutae 6-12 and with Chinese medicine original
The cyclodextrin of the parts by weight such as material is made,
Specifically the production method is as follows: (1) weigh Rehmannia glutinosa and cut into particle, the water that Rehmannia glutinosa weight ratio is 1:1 is added and is ground into
Paste, it is spare；Weigh prepared fleece flower root, fructus lycii is first dried, it is spare to be then comminuted into 24 mesh powder, weigh Semen Cuscutae pulverize it is standby
With；(2) being pulverized and mixed paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae and medicinal material total weight ratio is added is 1:3
Concentration is the alcohol of 96%v/v, stirs evenly, soak at room temperature 12 days, is sufficiently stirred daily during immersion 1 time, after immersion,
Filters pressing is carried out, collects alcohol soak, filter residue is spare；(3) by alcohol soak obtained by step (2), simultaneously low temperature is dense for recovered alcohol
It is spare to shorten thick paste into；(4) water that crude drug weight ratio is 1:8 is added in the filter residue in step (2), heating is boiled 2 hours, is filtered
Decoction liquor is taken, filter residue adds the water that crude drug weight ratio is 1:5, and heating is boiled 1.5 hours, and leaching decoction liquor discards filter
Slag；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, it is concentrated spare at thick paste；(6) by step (3) and step
Suddenly (2) gained thick paste mixing respectively, then will be added sequentially to mix in thick do after deer horn glue and colla carapacis et plastri testudinis respectively molten, sufficiently grind
It is even, the cyclodextrin of the parts by weight such as medicinal material is added, is placed in and carries out being fully ground 3 hours, after grinding in ball mill, extract
Material is 5-6%w/w through drying to water content, pulverizes, and crosses 80 meshes to get compound Rehmannia glutinosa combined extracts.
2. a kind of preparation method of compound Rehmannia glutinosa combined extracts, it is characterized in that by the Chinese medicine material Rehmannia glutinosa of following parts by weight
11-13, prepared fleece flower root 8-10, fructus lycii 7-11, deer horn glue 4-6, colla carapacis et plastri testudinis 5-7, Semen Cuscutae 8-10 and with the weight such as Chinese medicine material
The cyclodextrin of amount part is made,
Specifically the production method is as follows: (1) weigh Rehmannia glutinosa and cut into particle, the water that Rehmannia glutinosa weight ratio is 1:1 is added and is ground into
Paste, it is spare；Weigh prepared fleece flower root, fructus lycii is first dried, it is spare to be then comminuted into 24 mesh powder, weigh Semen Cuscutae pulverize it is standby
With；(2) being pulverized and mixed paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae and medicinal material total weight ratio is added is 1:3
Concentration is the alcohol of 96%v/v, stirs evenly, soak at room temperature 12 days, is sufficiently stirred daily during immersion 1 time, after immersion,
Filters pressing is carried out, collects alcohol soak, filter residue is spare；(3) by alcohol soak obtained by step (2), simultaneously low temperature is dense for recovered alcohol
It is spare to shorten thick paste into；(4) water that crude drug weight ratio is 1:8 is added in the filter residue in step (2), heating is boiled 2 hours, is filtered
Decoction liquor is taken, filter residue adds the water that crude drug weight ratio is 1:5, and heating is boiled 1.5 hours, and leaching decoction liquor discards filter
Slag；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, it is concentrated spare at thick paste；(6) by step (3) and step
Suddenly (2) gained thick paste mixing respectively, then will be added sequentially to mix in thick do after deer horn glue and colla carapacis et plastri testudinis respectively molten, sufficiently grind
It is even, the cyclodextrin of the parts by weight such as medicinal material is added, is placed in and carries out being fully ground 3 hours, after grinding in ball mill, extract
Material is 5-6%w/w through drying to water content, pulverizes, and crosses 80 meshes to get compound Rehmannia glutinosa combined extracts.
3. a kind of preparation method of compound Rehmannia glutinosa combined extracts, it is characterized in that by the Chinese medicine material Rehmannia glutinosa of following parts by weight
12, it prepared fleece flower root 9, fructus lycii 9, deer horn glue 5, colla carapacis et plastri testudinis 6, Semen Cuscutae 9 and is made with the cyclodextrin of the parts by weight such as Chinese medicine material,
Specifically the production method is as follows: (1) weigh Rehmannia glutinosa and cut into particle, the water that Rehmannia glutinosa weight ratio is 1:1 is added and is ground into
Paste, it is spare；Weigh prepared fleece flower root, fructus lycii is first dried, it is spare to be then comminuted into 24 mesh powder, weigh Semen Cuscutae pulverize it is standby
With；(2) being pulverized and mixed paste Rehmannia glutinosa, prepared fleece flower root powder, medlar powder and Semen Cuscutae and medicinal material total weight ratio is added is 1:3
Concentration is the alcohol of 96%v/v, stirs evenly, soak at room temperature 12 days, is sufficiently stirred daily during immersion 1 time, after immersion,
Filters pressing is carried out, collects alcohol soak, filter residue is spare；(3) by alcohol soak obtained by step (2), simultaneously low temperature is dense for recovered alcohol
It is spare to shorten thick paste into；(4) water that crude drug weight ratio is 1:8 is added in the filter residue in step (2), heating is boiled 2 hours, is filtered
Decoction liquor is taken, filter residue adds the water that crude drug weight ratio is 1:5, and heating is boiled 1.5 hours, and leaching decoction liquor discards filter
Slag；(5) the secondary filtrate of gained in step (4) is merged, crosses 150 meshes, it is concentrated spare at thick paste；(6) by step (3) and step
Suddenly (2) gained thick paste mixing respectively, then will be added sequentially to mix in thick do after deer horn glue and colla carapacis et plastri testudinis respectively molten, sufficiently grind
It is even, the cyclodextrin of the parts by weight such as medicinal material is added, is placed in and carries out being fully ground 3 hours, after grinding in ball mill, extract
Material is 5-6%w/w through drying to water content, pulverizes, and crosses 80 meshes to get compound Rehmannia glutinosa combined extracts.
4. according to claim 1,2, method described in 3, which is characterized in that the cyclodextrin is beta-cyclodextrin (β-CYD), 2,
6- dimethyl-β-cyclodextrin (DM- β -- CYD), hydroxyethyl-β-cyclodextrin (HE- β-CYD), hydroxypropyl-β-cyclodextrin (HP- β-
CYD any one) and in sulfobutyl ether-beta-cyclodextrin (SBE- β-CYD).
5. according to claim 1,2, method described in 3, which is characterized in that the alcohol is food grade alcohol.
6. according to claim 1,2, method described in 3, which is characterized in that the water is pure water.
7. according to claim 1,2, method described in 3, which is characterized in that the condition of the low temperature concentration is temperature 50 C-
60℃；The drying is vacuum drying, and the condition of drying is temperature 50 C, vacuum degree 0.2kPa.
8. a kind of purposes of compound Rehmannia glutinosa combined extracts according to claim 1 to 3, which is characterized in that the extract
As the purposes for being prepared into granule, tablet, capsule, pill, oral solution or wine product.
9. the purposes of compound Rehmannia glutinosa combined extracts according to claim 8, which is characterized in that the tablet is bubble
Rise piece, chewable tablets and buccal tablet；The capsule is soft capsule and hard capsule；The pill is water pill, dripping pill, pellet
And honeyed bolus.
10. the purposes of compound Rehmannia glutinosa combined extracts according to claim 8, which is characterized in that the wine is white
Wine, grape wine, yellow rice wine and beer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910407844.0A CN110075186A (en) | 2019-05-16 | 2019-05-16 | A kind of preparation method and purposes of compound Rehmannia glutinosa combined extracts |
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| CN101904501A (en) * | 2010-08-02 | 2010-12-08 | 西北大学 | Functional food for relieving fatigue and preparation method thereof |
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| CN106434196A (en) * | 2016-08-27 | 2017-02-22 | 杨艳辉 | Wine containing Radix Ginseng, Fructus Lycii, tortoise-plastron glue and Colla Cornus Cervi |
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