CN110151909A - A kind of preparation and use of compound ginseng combined extracts - Google Patents
A kind of preparation and use of compound ginseng combined extracts Download PDFInfo
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- CN110151909A CN110151909A CN201910407811.6A CN201910407811A CN110151909A CN 110151909 A CN110151909 A CN 110151909A CN 201910407811 A CN201910407811 A CN 201910407811A CN 110151909 A CN110151909 A CN 110151909A
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- ginseng
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- longan
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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Abstract
The present invention relates to Chinese medicine manufacture field and field of functional food, and in particular to a kind of preparation and use of compound ginseng combined extracts.A kind of preparation method of compound ginseng combined extracts of the present invention, it is characterized in that by Chinese medicine material the ginseng 3-9, fructus lycii 6-12 of following parts by weight, hoveniae semoveniae semen 5-9, rhizoma polygonati 9-15, dried orange peel 3-10, it Hericium erinaceus 10-30, longan 9-15 and is made with the cyclodextrin of the parts by weight such as Chinese medicine material.A kind of compound ginseng combined extracts of the invention, routinely granule, tablet, capsule, pill or drink is made as the purposes for preparing functional food in technique.
Description
Technical field
The present invention relates to Chinese medicine manufacture fields, further relate to field of functional food, and in particular to a kind of compound ginseng combination
The preparation and use of extract.
Background technique
With the rapid raising of China's socio-economic development level, it is some in the past not that the people has begun attention change
Too reasonable eating habit, " science eaten, health living, living is permanent " have become the generally pursuit of people.National income
Increase and the level of consumption raising, and people is made to have stronger consuming capacity, it is sufficient to pay wholesome functional food
Condition is to higher spending.It is all these all to constitute the very strong driving force of current functional food Industry Quick Development.With society
Meeting movement of population, social frequent, the fashional consumption drunk into social life, some bring because the normal phase drinks to body thus
Harm and uncomfortable also become the unfavorable factor for influencing people's health.Thus, domestic some healthy food manufacturing enterprises
For liking the people to drink to develop the material combination of some dietotherapeutics, using tea or tea bag as marketing, such as by people
The Chinese traditional medicine compositions such as ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan.It is drunk due to these products to people and brings it
The factors such as bubble drink method cannot be unified, and Ganderwa is uncertain, lead to the unreasonable and uncertain of its dosage and cannot achieve reason
The application effect thought finally makes consumer produce trust crisis, functional food production and processing to functional food class product
Industry receives injury.For this purpose, carrying out deep processing to traditional dietotherapeutic utilization of resources modern science technique, make its effective component
It obtains rationally sufficiently extracting, its product can be become to be even more important to its usage, dosage accurate positionin.
The extract that the present invention is combined using ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan compound
Preparation and application, through retrieving, there is not yet relevant report and related patent application.
Summary of the invention
The object of the present invention is to provide a kind of preparations of compound ginseng combined extracts.
The present invention also aims to provide a kind of compound ginseng combined extracts as the use for being prepared into functional food
On the way.
The preparation method of a kind of compound ginseng combined extracts provided by the invention, which is characterized in that it is by following heavy
Measure the Chinese medicine material ginseng 3-9, fructus lycii 6-12, hoveniae semoveniae semen 5-9 of part, rhizoma polygonati 9-15, dried orange peel 3-10, Hericium erinaceus 10-30, longan
It 9-15 and is made with the cyclodextrin of the parts by weight such as Chinese medicine material, it is specific the preparation method is as follows: (1) is first respectively by Chinese medicine people
Ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan are dried, ginseng, fructus lycii, trifoliate orange after then weighing drying
It is spare that Dulcis, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan are respectively crushed into 10 mesh powder；(2) it is in medicinal material total weight ratio by ginseng pulverate
The alcohol that concentration is 99%v/v is added in 1:3, impregnates 7 days, is sufficiently stirred daily during immersion 1 time, after immersion under room temperature,
Filters pressing is carried out, takes alcohol soak to save backup, filter residue is spare；(3) by fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, osmanthus
The all medicinal material powder mixing of circle, it is the alcohol that 1:5 concentration is 70%v/v that medicinal material total weight ratio, which is added, is impregnated 12 days under room temperature, is impregnated
Period is sufficiently stirred 1 time, after immersion daily, carries out filters pressing, takes alcohol soak spare, filter residue is spare；(4) by step
(3) alcohol is flung in the alcohol soak low temperature concentration in, and to obtain concentrate spare；(5) filter residue in step (2) and step (3) is closed
And the water that crude drug total weight ratio is 1:5 is added, heating is boiled 1.5 hours, and leaching decoction liquor, filter residue presses crude drug gross weight
Amount ratio is that 1:3 adds water, and 1 hour leaching decoction liquor is boiled in heating, and filter residue adds the water that crude drug total weight ratio is 1:2,
Heating is boiled 0.5 hour, and leaching decoction liquor discards filter residue；(6) by decoction liquor merging three times in step (5), 150 meshes, warp are crossed
Be concentrated into specific gravity be 5.0 concentrate it is spare；(7) by step (6) concentrate and step (3) obtained by alcohol soak and
Concentrate obtained by step (4) merges, by the parts by weight such as medicinal material addition cyclodextrin, be placed in ball mill carry out being fully ground 2.5 it is small
When, after grinding, material is taken out, through dry to water content < 6%w/w, pulverize, crosses 80 meshes to get compound ginseng combination
Extract.
Present invention cyclodextrin (CYD) described above, can be beta-cyclodextrin (β-CYD), is also possible to 2,6- dimethyl-
Beta-cyclodextrin (DM- β -- CYD), hydroxyethyl-β-cyclodextrin (HE- β-CYD), hydroxypropyl-β-cyclodextrin (HP- β-CYD) and sulphur fourth
Any one in base ether-beta-cyclodextrin (SBE- β-CYD).
CYD is safe and non-toxic, pertinent regulations (the FAQ nutrition meeting according to the World Health Organization to food additives
NO46WHO/FOOD ADD/70.36), the starch of enzymology feature no longer needs to do toxicity research；Many experimental studies also turn out β-
CYD tool shows its LD of Mouse oral in very high safety, acute toxicity test50> 300 mg/kg, acute toxicity and chronic toxicity
Test, carcinogenic, mutagenicity test of teratogenesis etc. demonstrate this product using safe and non-toxic.The U.S., Japan pharmacopeia oneself B-CYD is recorded
To take orally auxiliary material: HP-B-CYD(hydroxypropyl-B- cyclodextrin) " the Handboofk of that has been write by United States Pharmacopeia and Wade A
Pharrnaceutical Excipients " record for injection supplementary material (Zhao Jie is such as edited, modern Chinese herbal medicine new agent technology,
Jiangsu science tech publishing house, 2 months 2007 the 1st edition, page 151).
Heretofore described alcohol refers both to be food grade alcohol when not making certain illustrated.
Heretofore described water is pure water when not making certain illustrated.
The temperature condition of low temperature concentration described above is 50-60 DEG C of temperature.
Present invention drying described above, for using vacuum drying, vacuum drying condition is temperature 50 C, vacuum degree
For 0.2kPa.
Compound ginseng combined extracts of the present invention, routinely granule, tablet, capsule, pill is made in technique
Or drink is as the purposes for preparing functional food.
The preparation of currently preferred a kind of compound ginseng combined extracts, it is characterized in that the Chinese medicine by following parts by weight is former
Expect ginseng 5-7, fructus lycii 8-10, hoveniae semoveniae semen 6-8, rhizoma polygonati 11-13, dried orange peel 6-8, Hericium erinaceus 15-25, longan 11-13 and in
The cyclodextrin of the parts by weight such as medicine raw material is made, specific the preparation method is as follows: (1) is first respectively by Chinese medicine ginseng, fructus lycii, trifoliate orange
Dulcis, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan are dried, ginseng, fructus lycii, hoveniae semoveniae semen after then weighing drying, rhizoma polygonati, old
It is spare that skin, Hericium erinaceus, longan are respectively crushed into 10 mesh powder；It (2) is that 1:3 addition concentration is in medicinal material total weight ratio by ginseng pulverate
The alcohol of 99%v/v is impregnated 7 days under room temperature, is sufficiently stirred daily during immersion 1 time, after immersion, is carried out filters pressing, is taken wine
Smart soak saves backup, and filter residue is spare；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed
It closes, it is the alcohol that 1:5 concentration is 70%v/v that medicinal material total weight ratio, which is added, is impregnated 12 days under room temperature, during immersion daily sufficiently
Stirring 1 time after immersion, carries out filters pressing, takes alcohol soak spare, filter residue is spare；(4) alcohol in step (3) is soaked
Alcohol is flung in bubble liquid low temperature concentration, and to obtain concentrate spare；(5) filter residue in step (2) and step (3) is merged, it is total that crude drug is added
Weight ratio is the water of 1:5, and heating is boiled 1.5 hours, leaching decoction liquor, and filter residue is that 1:3 adds water in crude drug total weight ratio,
1 hour leaching decoction liquor is boiled in heating, and filter residue adds the water that crude drug total weight ratio is 1:2, and heating is boiled 0.5 hour,
Leaching decoction liquor, discards filter residue；(6) by step (5) three times decoction liquor merge, cross 150 meshes, it is concentrated to specific gravity be 5.0
It is spare to obtain concentrate；(7) concentrate in step (6) is concentrated with obtained by alcohol soak obtained by step (3) and step (4)
Liquid merges, and cyclodextrin is added by parts by weight such as medicinal materials, is placed in ball mill and be fully ground 2.5 hours, after grinding, take
Material out pulverizes through dry to water content < 6%w/w, crosses 80 meshes to get compound ginseng combined extracts.
The preparation of the further preferred a kind of compound ginseng combined extracts of the present invention, it is characterized in that by following parts by weight
Chinese medicine material ginseng 6, fructus lycii 9, hoveniae semoveniae semen 7, rhizoma polygonati 12, dried orange peel 7, Hericium erinaceus 20, longan 12 and with the weight such as Chinese medicine material
Part cyclodextrin be made, it is specific the preparation method is as follows: (1) is first respectively by Chinese medicine ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, old
Skin, Hericium erinaceus, longan are dried, ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, osmanthus after then weighing drying
It is spare that circle is respectively crushed into 10 mesh powder；(2) by ginseng pulverate in medicinal material total weight ratio be 1:3 be added concentration be 99%v/v wine
Essence is impregnated 7 days under room temperature, is sufficiently stirred daily during immersion 1 time, after immersion, and filters pressing is carried out, and alcohol soak is taken to save
Spare, filter residue is spare；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed, it is total that medicinal material is added
Weight ratio is the alcohol that 1:5 concentration is 70%v/v, impregnates 12 days, is sufficiently stirred daily during immersion 1 time under room temperature, is impregnated
After, filters pressing is carried out, takes alcohol soak spare, filter residue is spare；(4) the alcohol soak low temperature in step (3) is concentrated
Flinging to alcohol, to obtain concentrate spare；(5) filter residue in step (2) and step (3) is merged, it is 1 that crude drug total weight ratio, which is added:
5 water, heating are boiled 1.5 hours, leaching decoction liquor, and filter residue is that 1:3 adds water in crude drug total weight ratio, and it is small that heating boils 1
When leaching decoction liquor, filter residue add crude drug total weight ratio be 1:2 water, heating boil 0.5 hour, leaching decoction liquor,
Discard filter residue；(6) by step (5) three times decoction liquor merge, cross 150 meshes, it is concentrated to specific gravity be 5.0 concentrate it is standby
With；(7) concentrate in step (6) is merged with concentrate obtained by alcohol soak obtained by step (3) and step (4), is pressed
Cyclodextrin is added in the parts by weight such as medicinal material, is placed in ball mill and be fully ground 2.5 hours, after grinding, takes out material, warp
Drying pulverizes to water content < 6%w/w, crosses 80 meshes to get compound ginseng combined extracts.
Ginseng is the dry root and rhizome of Araliaceae ginseng Panax ginseng C. A. Mey..
Ginseng nature and flavor are sweet, slight bitter, tepor, returns spleen, lung, the heart, kidney channel.Have replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforces the spleen to benefit the lung, it is raw
Saliva blood-nourishing, tranquilize the mind and promote the intelligence function.It to be taken off for physically weak, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough, injury thirst, and interior heat disappears
Yearningly, deficiency of qi and blood, prolonged illness void is thin, insomnia of palpitating with fear, impotence palace cold.
Utility analysis: ginseng is sweet in flavor, slight bitter and slightly warm in nature, main returns spleen, lung, the heart, kidney channel.Its tonifying Qi range is wide, Ji Neng great
Tonifying primordial Qi, but can tonifying lung gas, enriching spleen-QI, bushing gas and kidney tonifying gas, reinforce vital energy, the function of veins takes off admittedly without medicine can generation, to save
It endangers emergency treatment of collapse key medicine, is most suitable for because of profuse sweating, spits greatly, rush down greatly, vigour fictitious pole caused by big blood loss or serious disease, prolonged illness etc. is intended to take off, weak pulse desire
Syndrome of endangering again is waited absolutely, therefore " Sheng Nong's herbal classic is dredged " calls its " it is exhausted in hanging down to return yang-energy, empty evil in a moment ".Meanwhile traditional Chinese medicine is recognized
It is human life activity's motive power for vigour, vigour virtual loss necessarily causes the viscera functions such as lung spleen heart kidney low, occurs corresponding
Deficiency of vital energy performance, the function of reinforcing vital energy of ginseng also indirectly have the function that tonifying lung spleen heart kidney qi, therefore, the tonifying lung gas of ginseng,
The existing direct effect of the effect of enriching spleen-QI, bushing gas and kidney tonifying gas, and have indirectly-acting.Old friend's ginseng is longer than tonifying lung gas, temper, is apt to
In bushing gas, moreover it is possible to kidney tonifying gas has preferable therapeutic effect for Lung Qi deficiency, Spleen-Qi Deficiency, the heart qi deficiency and kidney qi deficiency, therefore " originally
Careless detailed outline " call its " controlling all asthenic symptoms of male woman ".
Ginseng can reinforce vital energy to support congenital and strengthening the spleen and replenishing qi to train the day after tomorrow, and sweet temperature enters spleen, energy " middle regulating and qi tonifying "
(Materia Medica of Decoction), " invigorating spleen " (" collected statements on the herbal foundation ") are tonifying spleen key medicine；All improper diet and overtirednesses, damp pathogen obstruction the spleen are worried beyond measure,
The card of caused spleen deficiency, available this product add taste application.Ginseng " specially entering lung " (" book on Chinese herbal medicine is looked for the truth "), " gas in energy tonifying lung " (" book on Chinese herbal medicine
Detailed outline "), " Dingchuan cough " (" book on Chinese herbal medicine covers bamboo fish trap ") " disappear phlegm in the heart " (" haigoushen "), is tonifying lung key medicine；The lung being damaged by lasted cough, scorching impairment of yin,
The caused deficiency syndrome of the lung or deficiency of both the lung and kidney person, available this product compatibility application.Ginseng reinforces vital energy, and then body fluid is full and not thirsty for gas foot,
Old friend's ginseng can promote the production of body fluid to quench thirst, and be used for body fluid deficiency syndrome, diabete.Ginseng reinforces vital energy, and vigour is filled, and the motive must support, and the mind obtains rather, the heart
Intelligence obtains clever, and has the effect of tranquilize the mind and promote the intelligence, for treating deficiency of heart-QI or heart kidney qi deficiency, the insomnia of heart spleen deficiency, amnesia etc..Ginseng
Gan Wen reinforces vital energy, and QI invigorating has the benefits of qi-blood tonifying with green blood, therefore available spleen of controlling sets the deficiency of vital energy, and it is insufficient to change source, blood deficiency chlorosis it
Card；Energy QI invigorating with supporing yang, therefore again with insufficiency of primordial QI, the Yang-function insufficiency of kidneyzang is controlled, demonstrate,prove by impotence palace cold etc. again.
In short, the function of ginseng is focused on and is reinforced vital energy, can also tonifying lung gas, enriching spleen-QI, bushing gas, kidney tonifying gas and promote the production of body fluid, calm the nerves
Intelligence development, therefore (Pharmacopoeia of the People's Republic of China clinical application palpus is compiled by Chinese Pharmacopoeia Commission to control the first key medicine of consumptive disease internal injury
Know that the prepared slices of Chinese crude drugs are rolled up, version in 2015, page 1079).
Shennong's Herbal " main tonifying five zang organs, soothe the nerves determine soul, and stop palpitate with fear removes pathogenic factor, improving eyesight, happily, intelligence development." " medicine
Property opinion) " main five hiding unsaturated vapor, the deficient impotence of general debility is weak, spit it is inverse do not eat, only cholera unhappiness vomiting, tonifying five zang organs six internal organs, Bao Zhongshou
Mind." Compendium of Material Medica " all asthenic symptoms of male woman are controlled, generate heat spontaneous perspiration, dizziness and headache, and regurgitation and emesis cuts off from malaria, and it slides and rushes down protracted dysentery, urine frequency
Number leaching drip, overstrain internal injury, apoplexy heatstroke, flaccidity syndrome and arthralgia syndrome are spitted blood, blood of coughing, lower blood, blood strangury, metrorrhagia, postpartum all diseases before tire."
Fructus lycii is the dry mature fruit of Lycium barbarum L. of solanaceae Lycium barbarum L..
Fructus lycii nature and flavor sweet and neutral.Return liver and kidney channel.Has nourishing liver and kidney, benefiting shrewd head function.For consumption consumptive loss, waist and knee acid
Bitterly, dizziness and tinnitus, impotence and seminal emission, Heat Diabetes, blood deficiency chlorosis, dusk day are unknown.
Utility analysis: fructus lycii is sweet in flavor mild-natured, enters liver kidney channel, is longer than nourshing kidney essence, tonifying liver blood, " Bencao Jingshu " says it: " for
Liver kidney kidney-KIN being deficient, the tired interior key medicine for vulcanizing benefit ", slides soreness and weakness of waist and knees caused by liver kidney blood and essence asthenia, dizziness and tinnitus, spermatorrhea
Smart, infertile, blurred vision etc. can apply.Fructus lycii energy benefiting essence-blood, " tranquilizing the mind " (" haigoushen "), can be used for deficiency of blood complexion
Sallow, palpitaition is out of strength；Puerperal exposure to wind consumptive disease damage, limbs pain, mind dysphoria, loss of appetite；Hematasthenic cough, night sweat spontaneous perspiration, hectic fever due to yin
Hectic fever, it is dysphoria in chestpalms-soles；Internal lesion caused by overexertion is deficient, and four limbs are thin thin out of strength；Married woman's postpartum deficient qi and blood, (the National Pharmacopeia committee member such as oligogalactia
Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs volume, version in 2015, page 1230 can be compiled).
Collective Notes to the Canon of Materia medica " nourishing the essence and strengthening QI, prosperous and powerful vagina." " haigoushen " " energy help essence various symptims and signs of deficiency, Yi Yanse bleach,
Improving eyesight calms the nerves, makes us long-lived."
Hoveniae semoveniae semen is the dry mature seed that Rhamnaceae plant trifoliate orange fears Hovenia dulcis Thunb..Nature and flavor sweet and neutral.Return stomach
Through.
Hoveniae semoveniae semen has smoothening secretion, relieving alcoholism, relieving restlessness function of quenching the thirst.Drunk for difficulty in urination and defecation, dysphoria and thirsty is vomitted
It spits.
Utility analysis: Semen Hoveniae (Fructus Hoveniae) smoothening secretion and reduce swelling.Stop to store caused oedema, difficulty in urination and defecation card for water-wet.This product
Kind relieving alcoholism, the heat of clear chest diaphragm and relieving restlessness of quenching the thirst.It is chiefly used in treating drunk, dysphoria with smothery sensation, thirsty, (Chinese Pharmacopoeia Commission compiles for vomiting
Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs volume, version in 2015, page 1230).
" the southern regions of the Yunnan Province book on Chinese herbal medicine " cloud: " all left right paralysis of paralysis are controlled, rheumatic numbness can relieving alcoholism；Or steep in wine and take it, also can relaxing muscles and tendons network,
Long term usage is made light of one's life by commiting suicide macrobiosis.
Rhizoma polygonati is liliaceous plant polygonatum kingianurn Polygonatum kingianum Coll.et Hemsl., rhizoma polygonati
The dry rhizome of Polygonatum sibiricum Red. or polygonatum cyrtonema Polygonatum cyrtonema Hua.
Rhizoma polygonati nature and flavor sweet and neutral.Returns spleen, lung, kidney channel.Have boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.For taste gas
Void, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis are interior
Heat quench one's thirst (Chinese Pharmacopoeia Commission compile the Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs volume, 2015
Version, page 1227).
Utility analysis: rhizoma polygonati is sweet in flavor mild-natured, owner's the spleen channel, can nourish spleen yin and invigoration spleen qi, is that treatment taste are empty
It is weak, fatigue and asthenia, the good medicine of dry deficiency of food, therefore " Mingyi Bielu " says that its " tonifying middle-Jiao and Qi ", " book on Chinese herbal medicine is just read " " this flavour of a drug is sweet such as title
Maltosemalt sugar, the flat profit of property, is the certified products of nourished spleen Yin ".Rhizoma polygonati is in sweet flavor mild-natured, enters lung channel, not only tonifying lung yin, but also simultaneous energy QI invigorating, for treatment
The good merchantable brand of the deficiency syndrome of the lung, impairment of yin cough caused by dryness, deficiency syndrome of the lung overstrain cough hemoptysis and the deficiency syndrome of the lung, which are breathed with cough, can be selected.Rhizoma polygonati enters kidney channel, is longer than enriching yin, and and benefit
Gas, by flat tonifying spleen lung kidney can the raw marrow of replenishing essence, it is strong to consolidate, be usually used in treating asthenia of essence and blood, soreness and weakness of waist and knees, poliosis,
Heat Diabetes.
Rhizoma polygonati matches fructus lycii, and rhizoma polygonati is longer than nourishing Yin and moistening lung, and fructus lycii is good at nourishing kidney and replenishing pneuma.Two medicine compatibilities, can enhance qi-restoratives
And strengthening the essence gas, the effect of moistening lung and cough-relieving, be suitable for lung deficiency of the kidney it is empty caused by the soreness of waist pass out semen, (Chinese Pharmacopoeia Commission compiles for cough etc.
Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs volume, version in 2015, page 1227).
Compendium of Material Medica " mends all void, only fever and chills, replenishing essence marrow." " new compilation of materia medica " " flat to fill blood and moisten."
Dried orange peel is the dry mature skin of rutaceae orange Citrus reticulata Blanco and its variety.
Dried orange peel is bitter in taste, acrid in flavour and warm in nature.Return lung, the spleen channel.
Dried orange peel has regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm function.For abdominal fullness and distention, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Utility analysis: the pungent scattered bitter drop of dried orange peel is warm-natured, and fragrance is amusing, and is longer than regulating qi-flowing for strengthening spleen, fast diaphragm in tune, and drop check is spat, fitted
For abdominal distention caused by the taste stagnation of the circulation of vital energy, nausea and vomiting, diarrhea etc..In addition, take this product regulating qi-flowing for strengthening spleen, it is dry it is mild in function,
Often with qi-restoratives medicine with taking, can be allowed to mend without stagnant, more preferably (" Chinese people's republicanism is compiled to performance benefiting action by Chinese Pharmacopoeia Commission
State's pharmacopeia " clinical application notice prepared slices of Chinese crude drugs volume, version in 2015,668-669 pages).
Hericium erinaceus, also known as Hericium erinaceus.Hericium erinaceus is tooth bacterium section Hericium fungi Hericium erinaceus Fructificatio
The fructification of Hericii Erinacei, Hydnum Fructificatio Hericii Coralloidis.
It is recorded according to " dictionary of medicinal plant " second edition (3376-3377 pages of volume two): Hericium erinaceus nature and flavor sweet and neutral." supported with invigorating the spleen
Stomach is calmed the nerves, anti-cancer function, cures mainly asthenia, indigestion, insomnia, gastroduodenal ulcer, chronic gastritis." in the whole nation
Glossary of Herbs and Drugs ": " relieving the five internal organs, it is aid digestion.Indigestion is controlled, neurasthenia is in poor health." Liu Bo " Chinese medicinal fungi ": " benefit
The five internal organs, aid digestion, nourishing, anticancer.Control gastric ulcer."
Dried longan pulp is also known as arillus longan, begins to carry Shennong's Herbal, is classified as top grade.Dried longan pulp is Sapindaceae aiphyllium plant dragon
Eye Euphoria longan(Lour) Steud. maturation is dry or semiarid aril.Nature and flavor are sweet, flat.Channel tropism: enter the heart,
The spleen channel.Have nourishing the heart and spleen, nourishing blood and tranquilization, intelligence development functions.For palpitating with fear, amnesia, insomnia etc. diseases.Clinic is mainly used for treatment and painstaking effort
Empty related neurasthenia is presented with the symptoms such as insomnia, amnesia, palpitation with fear (Cui Shude chief editor " Chinese medicine is complete works of ", Heilungkiang science skill
Art publishing house publishes, August the 1st edition in 1989, the 555-556 pages).
The preparation of the above-mentioned compound ginseng combined extracts of the present invention, plays coordination between so that medicinal material is combined
With the advantageous application of reconciliation, for drunk, dysphoria with smothery sensation is thirsty to be apt to relieving alcoholism.And can deficiency of spleen-QI and stomach-QI, body because caused by drunk it is tired
Out of strength, deficiency of stomach-Yin, dry deficiency of food, the deficiency of liver-yin and kidney-yin, the waist and knee acid syndromes such as weak have good opsonic action.Compound ginseng combination
The preparation of extract extracts its medicinal material essence using modern crafts, can be conducive to the reduction of medicinal material dosage, and convenient to take, this hair
Bright product not only quantitatively can directly be taken, can also be from the convenience of application by compound ginseng combined extracts and pharmacy or food
Acceptable auxiliary material is hybridly prepared into granule, tablet, capsule, pill, beverage on product.Wherein tablet can also preferably steep
Piece, chewable tablets, buccal tablet are risen, because effervescent tablet, chewable tablets, buccal tablet have following clear superiority compared with conventional tablet: (1)
Convenient to take, due to preparing these tablets a certain amount of sugar will be added as excipient in chewable clothes, buccal, Ke Huashui, because
And it is in good taste, people gladly take, and effervescent tablet adds after water self-dissolving like one glass of beverage, and people is made to be happy to drink；(2) it absorbs fastly,
Bioavilability is high；(3) easy to carry, convenient transportation；(4) it is easy to quantify, dosage is accordingly accurate；Wherein capsule can be prepared into
Soft capsule and hard capsule, wherein pill can be prepared into water pill, dripping pill, pellet and honeyed bolus.
Specific embodiment
It is that the present invention is further illustrated, but does not constitute any limit to the scope of the present invention by following embodiment
System.
Embodiment 1
The preparation of compound ginseng combined extracts:
(1) pharmaceutical composition: ginseng 0.9kg, fructus lycii 0.8kg, hoveniae semoveniae semen 0.9kg, rhizoma polygonati 1.5kg, dried orange peel 1.0kg, Hericium erinaceus
The beta-cyclodextrin of 3.0kg, longan 1.5kg and 9.6kg.
(2) preparation method: (1) first respectively by Chinese medicine ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan
It is dried, ginseng 0.9kg, fructus lycii 0.8kg, hoveniae semoveniae semen 0.9kg, rhizoma polygonati 1.5kg, dried orange peel after then weighing drying
It is spare that 1.0kg, Hericium erinaceus 3.0kg, longan 1.5kg are respectively crushed into 10 mesh powder；(2) concentration is added in ginseng pulverate is 99%v/v
Edible alcohol 2.7kg, impregnate 7 days under room temperature, be sufficiently stirred daily during immersion 1 time, after immersion, through filters pressing, take wine
Smart soak saves backup, and filter residue is spare；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed
It closes, the edible alcohol 43.5kg that concentration is 70%v/v is added, impregnates 12 days, is sufficiently stirred daily during immersion 1 time under room temperature,
After immersion, leaching alcohol soak, filter residue is spare；(4) by the alcohol soak in step (3) using 50 DEG C of low temperature concentrations
Flinging to alcohol, to obtain concentrate spare；(5) filter residue in step (2) and step (3) is merged, the pure water of 48kg is added, heated
It boils 1.5 hours, leaching decoction liquor, filter residue is added to the pure water of 28.8kg, heating is boiled 1 hour, leaching decoction liquor, filter residue
The pure water of 19.2kg is added, heating is boiled 0.5 hour, and leaching decoction liquor discards filter residue；(6) it will be decocted three times in step (5)
Boil liquid merges, and crosses 150 meshes, it is spare that heating is concentrated into the concentrate that specific gravity is 5.0；(7) by the concentrate and step in step (6)
Suddenly concentrate obtained by alcohol soak and step (4) obtained by (2) merges, and 9.6kg beta-cyclodextrin is added, be placed in ball mill into
Row is fully ground 2.5 hours, after grinding, is taken out material, is placed in vacuum drier, temperature is 50 DEG C, vacuum degree is
It is 5.8%w/w that water content is dried under vacuum under conditions of 0.2kPa, is pulverized, and crosses 80 meshes to get compound ginseng and combines extraction
Object.
Routinely granule, tablet, capsule, pill or drink work is made in technique to the compound ginseng combined extracts
For the purposes for preparing functional food.
Embodiment 2
The preparation of compound ginseng combined extracts:
(1) pharmaceutical composition: ginseng 0.3kg, fructus lycii 0.6kg, hoveniae semoveniae semen 0.5kg, rhizoma polygonati 0.9kg, dried orange peel 0.3kg, Hericium erinaceus
The hydroxyethyl-β-cyclodextrin of 1.0kg, longan 0.9kg and 4.5kg.
(2) preparation method: (1) first respectively by Chinese medicine ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan
It is dried, ginseng 0.3kg, fructus lycii 0.6kg, hoveniae semoveniae semen 0.5kg, rhizoma polygonati 0.9kg, dried orange peel after then weighing drying
It is spare that 0.3kg, Hericium erinaceus 1.0kg, longan 0.9kg are respectively crushed into 10 mesh powder；(2) concentration is added in ginseng pulverate is 99%v/v
Edible alcohol 0.9kg, impregnate 7 days under room temperature, be sufficiently stirred daily during immersion 1 time, after immersion, through filters pressing, take wine
Smart soak saves backup, and filter residue is spare；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed
It closes, the edible alcohol 21kg that concentration is 70%v/v is added, impregnates 12 days, is sufficiently stirred daily during immersion 1 time under room temperature, soaked
After bubble, filters pressing takes alcohol soak, and filter residue is spare；(4) the alcohol soak in step (3) is dense using 60 DEG C of low temperature
Alcohol is flung in contracting, and to obtain concentrate spare；(5) filter residue in step (2) and step (3) is merged, the pure water of 22.5kg is added,
Heating is boiled 1.5 hours, leaching decoction liquor, and filter residue is added to the pure water of 13.5kg, and heating is boiled 1 hour, leaching decoction liquor,
Filter residue adds the pure water of 9kg, and heating is boiled 0.5 hour, and leaching decoction liquor discards filter residue；(6) by step (5) three times
Decoction liquor merges, and crosses 150 meshes, it is spare that heating is concentrated into the concentrate that specific gravity is 5.0；(7) by step (6) concentrate with
Concentrate obtained by alcohol soak obtained by step (2) and step (4) merges, and 4.5kg hydroxyethyl-β-cyclodextrin is added, is placed in
It carries out being fully ground 2.5 hours, after grinding in ball mill, takes out material, be placed in vacuum drier, be 50 in temperature
DEG C, water content is dried under vacuum under conditions of being 0.2kPa is 5.5%w/w to vacuum degree, is pulverized, cross 80 meshes to get compound
Ginseng combined extracts.
Routinely granule, tablet, capsule, pill or drink work is made in technique to the compound ginseng combined extracts
For the purposes for preparing functional food.
Embodiment 3
The preparation of compound ginseng combined extracts:
(1) pharmaceutical composition: ginseng 0.9kg, fructus lycii 1.2g, hoveniae semoveniae semen 0.9kg, rhizoma polygonati 1.5kg, dried orange peel 1.0kg, Hericium erinaceus
The hydroxypropyl-β-cyclodextrin of 3.0kg, longan 1.5kg and 10kg.
(2) preparation method: (1) first respectively by Chinese medicine ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan
It is dried, ginseng 0.9kg, fructus lycii 1.2kg, hoveniae semoveniae semen 0.9kg, rhizoma polygonati 1.5kg, dried orange peel after then weighing drying
It is spare that 1.0kg, Hericium erinaceus 3.0kg, longan 1.5kg are respectively crushed into 10 mesh powder；(2) concentration is added in ginseng pulverate is 99%v/v
Edible alcohol 2.7kg, impregnate 7 days under room temperature, be sufficiently stirred daily during immersion 1 time, after immersion, through filters pressing, take wine
Smart soak saves backup, and filter residue is spare；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed
It closes, the edible alcohol 27.3kg that concentration is 70%v/v is added, impregnates 12 days, is sufficiently stirred daily during immersion 1 time under room temperature,
After immersion, filters pressing takes alcohol soak, and filter residue is spare；(4) the alcohol soak in step (3) is used into 55 DEG C of low temperature
Alcohol is flung in concentration, and to obtain concentrate spare；(5) filter residue in step (2) and step (3) is merged, the pure water of 50kg is added,
Heating is boiled 1.5 hours, leaching decoction liquor, and filter residue is added to the pure water of 30kg, and heating is boiled 1 hour, leaching decoction liquor, filter
Slag adds the pure water of 20kg, and heating is boiled 0.5 hour, and leaching decoction liquor discards filter residue；(6) it will be decocted three times in step (5)
Boil liquid merges, and crosses 150 meshes, it is spare that heating is concentrated into the concentrate that specific gravity is 5.0；(7) by the concentrate and step in step (6)
Suddenly concentrate obtained by alcohol soak and step (4) obtained by (2) merges, and 10kg hydroxypropylβ-cyclodextrin is added, is placed in ball milling
It carries out being fully ground 2.5 hours, after grinding in machine, takes out material, be placed in vacuum drier, be 50 DEG C, very in temperature
Reciprocal of duty cycle is dried under vacuum to water content under conditions of being 0.2kPa be 5.6%w/w, is pulverized, and crosses 80 meshes to get compound ginseng group
Close extract.
Routinely granule, tablet, capsule, pill or drink work is made in technique to the compound ginseng combined extracts
For the purposes for preparing functional food.
Embodiment 4
The preparation of compound ginseng combined extracts:
(1) pharmaceutical composition: ginseng 0.6kg, fructus lycii 0.9kg, hoveniae semoveniae semen 0.7kg, rhizoma polygonati 1.2kg, dried orange peel 0.7kg, Hericium erinaceus
The 2,6- dimethyl-β-cyclodextrin of 2.0kg, longan 1.2kg and 7.3kg.
(2) preparation method: (1) first respectively by Chinese medicine ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan
It is dried, ginseng 0.6kg, fructus lycii 0.9kg, hoveniae semoveniae semen 0.7kg, rhizoma polygonati 1.2kg, dried orange peel after then weighing drying
It is spare that 0.7kg, Hericium erinaceus 2.0kg, longan 1.2kg are respectively crushed into 10 mesh powder；(2) concentration is added in ginseng pulverate is 99%v/v
Edible alcohol 1.8kg, impregnate 7 days under room temperature, be sufficiently stirred daily during immersion 1 time, after immersion, through filters pressing, take wine
Smart soak saves backup, and filter residue is spare；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed
It closes, the edible alcohol 20.1kg that concentration is 70%v/v is added, impregnates 12 days, is sufficiently stirred daily during immersion 1 time under room temperature,
After immersion, filters pressing takes alcohol soak, and filter residue is spare；(4) the alcohol soak in step (3) is used into 53 DEG C of low temperature
Alcohol is flung in concentration, and to obtain concentrate spare；(5) filter residue in step (2) and step (3) is merged, the pure of 36.5kg is added
Water, heating are boiled 1.5 hours, leaching decoction liquor, and filter residue is added to the pure water of 21.9kg, and heating is boiled 1 hour, and leaching decocts
Liquid, filter residue add the pure water of 14.6kg, and heating is boiled 0.5 hour, and leaching decoction liquor discards filter residue；(6) by step (5)
In three times decoction liquor merge, cross 150 meshes, heating be concentrated into specific gravity be 5.0 concentrate it is spare；It (7) will be dense in step (6)
Contracting liquid merges with concentrate obtained by alcohol soak obtained by step (2) and step (4), and 7.2kg2,6- dimethyl-β-ring is added
Dextrin is placed in ball mill and be fully ground 2.5 hours, after grinding, takes out material, is placed in vacuum drier,
Temperature is 50 DEG C, water content is dried under vacuum under conditions of being 0.2kPa is 5.4%w/w to vacuum degree, is pulverized, and 80 meshes are crossed,
Up to compound ginseng combined extracts.
Routinely granule, tablet, capsule, pill or drink work is made in technique to the compound ginseng combined extracts
For the purposes for preparing functional food.
Embodiment 5
The preparation of compound ginseng combined extracts:
(1) pharmaceutical composition: ginseng 0.5kg, fructus lycii 0.8kg, hoveniae semoveniae semen 0.6kg, rhizoma polygonati 1.1kg, dried orange peel 0.6kg, Hericium erinaceus
The sulfobutyl ether-beta-cyclodextrin of 1.5kg, longan 1.1kg and 6.2kg.
(2) preparation method: (1) first respectively by Chinese medicine ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan
It is dried, ginseng 0.9kg, fructus lycii 0.8kg, hoveniae semoveniae semen 0.6kg, rhizoma polygonati 1.1kg, dried orange peel after then weighing drying
It is spare that 0.6kg, Hericium erinaceus 1.5kg, longan 1.1kg are respectively crushed into 10 mesh powder；(2) concentration is added in ginseng pulverate is 99%v/v
Edible alcohol 1.5kg, impregnate 7 days under room temperature, be sufficiently stirred daily during immersion 1 time, after immersion, through filters pressing, take wine
Smart soak saves backup, and filter residue is spare；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed
It closes, the edible alcohol 17.1kg that concentration is 70%v/v is added, impregnates 12 days, is sufficiently stirred daily during immersion 1 time under room temperature,
After immersion, filters pressing takes alcohol soak, and filter residue is spare；(4) the alcohol soak in step (3) is used into 58 DEG C of low temperature
Alcohol is flung in concentration, and to obtain concentrate spare；(5) filter residue in step (2) and step (3) is merged, the pure water of 31kg is added,
Heating is boiled 1.5 hours, leaching decoction liquor, and filter residue is added to the pure water of 18.6kg, and heating is boiled 1 hour, leaching decoction liquor,
Filter residue adds the pure water of 12.4kg, and heating is boiled 0.5 hour, and leaching decoction liquor discards filter residue；It (6) will be three in step (5)
Secondary decoction liquor merges, and crosses 150 meshes, it is spare that heating is concentrated into the concentrate that specific gravity is 5.0；(7) by the concentrate in step (6)
Merge with concentrate obtained by alcohol soak obtained by step (2) and step (4), 6.2kg sulfobutyl ether-beta-cyclodextrin be added,
It is placed in ball mill and be fully ground 2.5 hours, after grinding, take out material, be placed in vacuum drier, be in temperature
50 DEG C, water content is dried under vacuum under conditions of being 0.2kPa is 5.6%w/w to vacuum degree, is pulverized, cross 80 meshes to get multiple
Fang Rencan combined extracts.
Routinely granule, tablet, capsule, pill or drink work is made in technique to the compound ginseng combined extracts
For the purposes for preparing functional food.
Embodiment 6
The preparation of compound ginseng combined extracts:
(1) pharmaceutical composition: ginseng 0.7kg, fructus lycii 1.0kg, hoveniae semoveniae semen 0.8kg, rhizoma polygonati 1.3kg, dried orange peel 0.8kg, Hericium erinaceus
The hydroxypropyl-β-cyclodextrin of 2.5kg, longan 1.3kg and 8.4kg.
(2) preparation method: (1) first respectively by Chinese medicine ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan
It is dried, ginseng 0.7kg, fructus lycii 1.0kg, hoveniae semoveniae semen 0.8kg, rhizoma polygonati 1.3kg, dried orange peel after then weighing drying
It is spare that 0.8kg, Hericium erinaceus 2.5kg, longan 1.3kg are respectively crushed into 10 mesh powder；(2) concentration is added in ginseng pulverate is 99%v/v
Edible alcohol 2.1kg, impregnate 7 days under room temperature, be sufficiently stirred daily during immersion 1 time, after immersion, through filters pressing, take wine
Smart soak saves backup, and filter residue is spare；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed
It closes, the edible alcohol 38.5kg that concentration is 70%v/v is added, impregnates 12 days, is sufficiently stirred daily during immersion 1 time under room temperature,
After immersion, filters pressing takes alcohol soak, and filter residue is spare；(4) the alcohol soak in step (3) is used into 52 DEG C of low temperature
Alcohol is flung in concentration, and to obtain concentrate spare；(5) filter residue in step (2) and step (3) is merged, the pure water of 42kg is added,
Heating is boiled 1.5 hours, leaching decoction liquor, and filter residue is added to the pure water of 25.2kg, and heating is boiled 1 hour, leaching decoction liquor,
Filter residue adds the pure water of 16.8kg, and heating is boiled 0.5 hour, and leaching decoction liquor discards filter residue；It (6) will be three in step (5)
Secondary decoction liquor merges, and crosses 150 meshes, it is spare that heating is concentrated into the concentrate that specific gravity is 5.0；(7) by the concentrate in step (6)
Merge with concentrate obtained by alcohol soak obtained by step (2) and step (4), 8.4kg hydroxypropyl-β-cyclodextrin is added, sets
In carrying out being fully ground 2.5 hours, after grinding in ball mill, material is taken out, is placed in vacuum drier, is 50 in temperature
DEG C, water content is dried under vacuum under conditions of being 0.2kPa is 5.6%w/w to vacuum degree, is pulverized, cross 80 meshes to get compound
Ginseng combined extracts.
Routinely granule, tablet, capsule, pill or drink work is made in technique to the compound ginseng combined extracts
For the purposes for preparing functional food.
Claims (9)
1. a kind of preparation method of compound ginseng combined extracts, which is characterized in that it is by the Chinese medicine material of following parts by weight
Ginseng 3-9, fructus lycii 6-12, hoveniae semoveniae semen 5-9, rhizoma polygonati 9-15, dried orange peel 3-10, Hericium erinaceus 10-30, longan 9-15 and with Chinese medicine original
The cyclodextrin of the parts by weight such as material is made, specific the preparation method is as follows: (1) is first respectively by Chinese medicine ginseng, fructus lycii, trifoliate orange Dulcis
Son, rhizoma polygonati, dried orange peel, Hericium erinaceus, longan are dried, ginseng, fructus lycii, hoveniae semoveniae semen after then weighing drying, rhizoma polygonati, old
It is spare that skin, Hericium erinaceus, longan are respectively crushed into 10 mesh powder；It (2) is that 1:3 addition concentration is in medicinal material total weight ratio by ginseng pulverate
The alcohol of 99%v/v is impregnated 7 days under room temperature, is sufficiently stirred daily during immersion 1 time, after immersion, is carried out filters pressing, is taken wine
Smart soak saves backup, and filter residue is spare；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed
It closes, it is the alcohol that 1:5 concentration is 70%v/v that medicinal material total weight ratio, which is added, is impregnated 12 days under room temperature, during immersion daily sufficiently
Stirring 1 time after immersion, carries out filters pressing, takes alcohol soak spare, filter residue is spare；(4) alcohol in step (3) is soaked
Alcohol is flung in bubble liquid low temperature concentration, and to obtain concentrate spare；(5) filter residue in step (2) and step (3) is merged, it is total that crude drug is added
Weight ratio is the water of 1:5, and heating is boiled 1.5 hours, leaching decoction liquor, and filter residue is that 1:3 adds water in crude drug total weight ratio,
1 hour leaching decoction liquor is boiled in heating, and filter residue adds the water that crude drug total weight ratio is 1:2, and heating is boiled 0.5 hour,
Leaching decoction liquor, discards filter residue；(6) by step (5) three times decoction liquor merge, cross 150 meshes, it is concentrated to specific gravity be 5.0
It is spare to obtain concentrate；(7) concentrate in step (6) is concentrated with obtained by alcohol soak obtained by step (3) and step (4)
Liquid merges, and cyclodextrin is added by parts by weight such as medicinal materials, is placed in ball mill and be fully ground 2.5 hours, after grinding, take
Material out pulverizes through dry to water content < 6%w/w, crosses 80 meshes to get compound ginseng combined extracts.
2. a kind of preparation of compound ginseng combined extracts, which is characterized in that it is the Chinese medicine material ginseng by following parts by weight
5-7, fructus lycii 8-10, hoveniae semoveniae semen 6-8, rhizoma polygonati 11-13, dried orange peel 6-8, Hericium erinaceus 15-25, longan 11-13 and and Chinese medicine material
Etc. the cyclodextrin of parts by weight be made, it is specific the preparation method is as follows: (1) first respectively by Chinese medicine ginseng, fructus lycii, hoveniae semoveniae semen,
Rhizoma polygonati, dried orange peel, Hericium erinaceus, longan are dried, ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, monkey after then weighing drying
Head mushroom, that longan is respectively crushed into 10 mesh powder is spare；(2) by ginseng pulverate in medicinal material total weight ratio be 1:3 be added concentration be 99%
The alcohol of v/v is impregnated 7 days under room temperature, is sufficiently stirred daily during immersion 1 time, after immersion, carries out filters pressing, alcohol is taken to soak
Bubble liquid saves backup, and filter residue is spare；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed, is added
Entering medicinal material total weight ratio is the alcohol that 1:5 concentration is 70%v/v, impregnates 12 days under room temperature, is sufficiently stirred 1 during immersion daily
It is secondary, after immersion, filters pressing is carried out, takes alcohol soak spare, filter residue is spare；(4) the alcohol soak in step (3) is low
Alcohol is flung in temperature concentration, and to obtain concentrate spare；(5) filter residue in step (2) and step (3) is merged, crude drug total weight ratio is added
Example is the water of 1:5, and heating is boiled 1.5 hours, leaching decoction liquor, and filter residue is that 1:3 adds water in crude drug total weight ratio, and heating is boiled
1 hour leaching decoction liquor is boiled, filter residue adds the water that crude drug total weight ratio is 1:2, and heating is boiled 0.5 hour, and leaching is decocted
Boil liquid discards filter residue；(6) by decoction liquor merging three times in step (5), 150 meshes are crossed, it is concentrated to be concentrated to specific gravity for 5.0
Liquid is spare；(7) concentrate in step (6) is closed with concentrate obtained by alcohol soak obtained by step (3) and step (4)
And cyclodextrin is added by parts by weight such as medicinal materials, and it is placed in and carries out being fully ground 2.5 hours, after grinding in ball mill, extract
Material pulverizes through dry to water content < 6%w/w, crosses 80 meshes to get compound ginseng combined extracts.
3. a kind of preparation of compound ginseng combined extracts, which is characterized in that it is the Chinese medicine material ginseng by following parts by weight
6, fructus lycii 9, hoveniae semoveniae semen 7, rhizoma polygonati 12, dried orange peel 7, Hericium erinaceus 20, longan 12 and the cyclodextrin system with the parts by weight such as Chinese medicine material
At specific the preparation method is as follows: (1) is first respectively by Chinese medicine ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, osmanthus
Circle is dried, and ginseng, fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, the longan after then weighing drying are respectively crushed into
10 mesh powder are spare；(2) it is alcohol that 1:3 is added that concentration is 99%v/v in medicinal material total weight ratio by ginseng pulverate, impregnates under room temperature
It 7 days, is sufficiently stirred daily during immersion 1 time, after immersion, carries out filters pressing, take alcohol soak to save backup, filter residue is standby
With；(3) fructus lycii, hoveniae semoveniae semen, rhizoma polygonati, dried orange peel, Hericium erinaceus, all medicinal material powders of longan are mixed, medicinal material total weight ratio, which is added, is
1:5 concentration is the alcohol of 70%v/v, impregnates 12 days, is sufficiently stirred daily during immersion 1 time, after immersion under room temperature, is carried out
Filters pressing takes alcohol soak spare, and filter residue is spare；(4) by step (3) alcohol soak low temperature concentration fling to alcohol obtain it is dense
Contracting liquid is spare；(5) filter residue in step (2) and step (3) is merged, the water that crude drug total weight ratio is 1:5 is added, heating is boiled
Boiling 1.5 hours, leaching decoction liquor, filter residue are that 1:3 adds water in crude drug total weight ratio, and 1 hour leaching decoction liquor is boiled in heating,
Filter residue adds the water that crude drug total weight ratio is 1:2, and heating is boiled 0.5 hour, and leaching decoction liquor discards filter residue；(6) will
In step (5) three times decoction liquor merge, cross 150 meshes, it is concentrated to specific gravity be 5.0 concentrate it is spare；(7) by step (6)
In concentrate and step (3) obtained by concentrate obtained by alcohol soak and step (4) merges, by the addition of the parts by weight such as medicinal material
Cyclodextrin is placed in ball mill and be fully ground 2.5 hours, after grinding, takes out material, through dry to water content <
6%w/w pulverizes, and crosses 80 meshes to get compound ginseng combined extracts.
4. method according to claim 1 to 3, which is characterized in that the cyclodextrin (CYD) is beta-cyclodextrin (β-
CYD), 2,6- dimethyl-β-cyclodextrin (DM- β -- CYD), hydroxyethyl-β-cyclodextrin (HE- β-CYD), hydroxypropyl-β-cyclodextrin
Any one in (HP- β-CYD) and sulfobutyl ether-beta-cyclodextrin (SBE- β-CYD).
5. method according to claim 1 to 3, which is characterized in that the alcohol is food grade alcohol；The water is
Pure water.
6. method according to claim 1 to 3, which is characterized in that the condition of the low temperature concentration is 50-60 DEG C of temperature.
7. method according to claim 1 to 3, which is characterized in that the drying is vacuum drying；The vacuum drying
Condition be temperature 50 C, vacuum degree 0.2kPa.
8. the purposes of -3 compound ginseng combined extracts according to claim 1, which is characterized in that routinely technique is made
Granula, tablet, capsule, pill or drink are as the purposes for preparing functional food.
9. purposes according to claim 8, which is characterized in that the tablet is effervescent tablet, chewable tablets and buccal tablet；Institute
The capsule stated is soft capsule and hard capsule；The pill is water pill, dripping pill, pellet and honeyed bolus.
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