CN110050075B - 用于确定特定癌症的癌症疗法的功效的血液样品的数字分析 - Google Patents
用于确定特定癌症的癌症疗法的功效的血液样品的数字分析 Download PDFInfo
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- CN110050075B CN110050075B CN201780075515.XA CN201780075515A CN110050075B CN 110050075 B CN110050075 B CN 110050075B CN 201780075515 A CN201780075515 A CN 201780075515A CN 110050075 B CN110050075 B CN 110050075B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413952P | 2016-10-27 | 2016-10-27 | |
| US62/413,952 | 2016-10-27 | ||
| PCT/US2017/058855 WO2018081625A2 (en) | 2016-10-27 | 2017-10-27 | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110050075A CN110050075A (zh) | 2019-07-23 |
| CN110050075B true CN110050075B (zh) | 2024-04-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780075515.XA Active CN110050075B (zh) | 2016-10-27 | 2017-10-27 | 用于确定特定癌症的癌症疗法的功效的血液样品的数字分析 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11371101B2 (enExample) |
| EP (2) | EP3985127A1 (enExample) |
| JP (2) | JP7195252B2 (enExample) |
| CN (1) | CN110050075B (enExample) |
| WO (1) | WO2018081625A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2016238253B2 (en) | 2015-03-25 | 2022-06-16 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
| WO2018081625A2 (en) * | 2016-10-27 | 2018-05-03 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
| WO2020006098A2 (en) * | 2018-06-26 | 2020-01-02 | Children's National Medical Center | Tumor-associated markers for detection of minimal residual disease using digital droplet pcr |
| US12358918B2 (en) | 2018-11-14 | 2025-07-15 | The Broad Institute, Inc. | Aryl hydrocarbon receptor (AHR) activator compounds as cancer therapeutics |
| TWI790399B (zh) * | 2019-08-30 | 2023-01-21 | 長庚大學 | 循環腫瘤細胞資訊評估方法及其分析方法 |
| CN114830258A (zh) * | 2019-09-16 | 2022-07-29 | 斯坦福大学托管董事会 | 基于乳腺癌的分子表征的治疗方法 |
| CN112698033A (zh) * | 2020-12-09 | 2021-04-23 | 复旦大学附属中山医院 | 一种血源性外泌体her2的检测方法及其应用 |
| WO2022196186A1 (ja) * | 2021-03-16 | 2022-09-22 | ソニーグループ株式会社 | 閉鎖系の自動試料分取システム |
| CN113292643A (zh) * | 2021-05-31 | 2021-08-24 | 南京市第二医院 | 一种肝癌肿瘤标志物及其应用 |
| JP2024527371A (ja) * | 2021-07-08 | 2024-07-24 | オウロテック インコーポレイテッド | 処置の有効性予測システム及び方法 |
| CN114395622A (zh) * | 2021-12-13 | 2022-04-26 | 深圳先进技术研究院 | 一种利用数字pcr检测循环肿瘤细胞egfr基因突变的方法及其应用 |
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| AU2015268617A1 (en) * | 2010-03-31 | 2016-01-07 | Sividon Diagnostics Gmbh | Method for breast cancer recurrence prediction under endocrine treatment |
| WO2016154600A1 (en) * | 2015-03-25 | 2016-09-29 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
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| US8535A (en) | 1851-11-18 | Stove-geate | ||
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| DE29623597U1 (de) | 1996-11-08 | 1999-01-07 | Eppendorf - Netheler - Hinz Gmbh, 22339 Hamburg | Temperierblock mit Temperiereinrichtungen |
| US20080050393A1 (en) | 1998-12-03 | 2008-02-28 | Tang Y Tom | Novel nucleic acids and polypeptides |
| CA2311201A1 (en) | 1999-08-05 | 2001-02-05 | Genset S.A. | Ests and encoded human proteins |
| CA2430981A1 (en) | 2000-12-08 | 2002-06-13 | Francois Bertucci | Gene expression profiling of primary breast carcinomas using arrays of candidate genes |
| US20030064385A1 (en) | 2001-05-16 | 2003-04-03 | Dressman Marlene Michelle | Genes expressed in breast cancer as prognostic and therapeutic targets |
| US20030073623A1 (en) | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| US20060275794A1 (en) | 2005-03-07 | 2006-12-07 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| US20070026417A1 (en) | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
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| EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| WO2009051734A1 (en) | 2007-10-17 | 2009-04-23 | The General Hospital Corporation | Microchip-based devices for capturing circulating tumor cells and methods of their use |
| US9068181B2 (en) | 2008-05-23 | 2015-06-30 | The General Hospital Corporation | Microfluidic droplet encapsulation |
| US20120252015A1 (en) | 2011-02-18 | 2012-10-04 | Bio-Rad Laboratories | Methods and compositions for detecting genetic material |
| WO2010037134A2 (en) | 2008-09-29 | 2010-04-01 | Stemlifeline, Inc. | Multi-stage stem cell carcinogenesis |
| US9625454B2 (en) | 2009-09-04 | 2017-04-18 | The Research Foundation For The State University Of New York | Rapid and continuous analyte processing in droplet microfluidic devices |
| US20110166030A1 (en) | 2009-09-30 | 2011-07-07 | Yixin Wang | Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells |
| EP4484577A3 (en) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| WO2011112903A2 (en) | 2010-03-11 | 2011-09-15 | Board Of Regents, The University Of Texas System | Quantitative rt-pcr detection for genes involved in epithelial mesenchymal transition in peripheral blood of breast cancer patients |
| HUE030164T2 (en) * | 2010-03-31 | 2017-05-29 | Sividon Diagnostics Gmbh | A method of predicting breast cancer recurrence during endocrine treatment |
| US9650629B2 (en) | 2010-07-07 | 2017-05-16 | Roche Molecular Systems, Inc. | Clonal pre-amplification in emulsion |
| EP2606353A4 (en) * | 2010-08-18 | 2014-10-15 | Caris Life Sciences Luxembourg Holdings | CIRCULATING BIOMARKERS FOR DISEASE |
| EP2678448A4 (en) | 2011-02-22 | 2014-10-01 | Caris Life Sciences Luxembourg Holdings S A R L | CIRCULATING BIOMARKERS |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| JP6247218B2 (ja) | 2011-10-24 | 2017-12-13 | ザ ジェネラル ホスピタル コーポレイション | 癌のバイオマーカー |
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| AU2013315128B2 (en) * | 2012-09-14 | 2019-01-03 | Memorial Sloan-Kettering Cancer Center | Genes associated with dasatinib sensitivity |
| WO2014047285A1 (en) | 2012-09-19 | 2014-03-27 | Paraskevi Giannakakou | Identifying taxane sensitivity in prostate cancer patients |
| WO2014075067A1 (en) * | 2012-11-12 | 2014-05-15 | Nanostring Technologies, Inc. | Methods to predict breast cancer outcome |
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| BR112016020953A2 (pt) * | 2014-03-13 | 2018-01-23 | Hoffmann La Roche | composto, kit, composição farmacêutica, uso de composto, método de tratamento e invenção |
| WO2015177184A1 (en) * | 2014-05-21 | 2015-11-26 | F. Hoffmann-La Roche Ag | Methods of treating pr-positive, luminal a breast cancer with pi3k inhibitor, pictilisib |
| DK3230736T3 (da) * | 2014-12-12 | 2020-06-08 | Celcuity Inc | Fremgangsmåder til måling af ErbB-signaleringsvejsaktivitet til at diagnosticere og behandle cancerpatienter |
| ES2719206T3 (es) | 2015-02-20 | 2019-07-09 | Comelz Spa | Procedimiento para cortar pieles naturales |
| CN107567502A (zh) | 2015-03-12 | 2018-01-09 | 詹森药业有限公司 | 用于预测前列腺癌的基于全血的mrna标记物和检测该mrna标记物的方法 |
| WO2018081625A2 (en) * | 2016-10-27 | 2018-05-03 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
-
2017
- 2017-10-27 WO PCT/US2017/058855 patent/WO2018081625A2/en not_active Ceased
- 2017-10-27 CN CN201780075515.XA patent/CN110050075B/zh active Active
- 2017-10-27 EP EP21212237.8A patent/EP3985127A1/en active Pending
- 2017-10-27 EP EP17865612.0A patent/EP3532642B1/en active Active
- 2017-10-27 JP JP2019522657A patent/JP7195252B2/ja active Active
- 2017-10-27 US US16/344,557 patent/US11371101B2/en active Active
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2022
- 2022-05-27 US US17/826,834 patent/US12331363B2/en active Active
- 2022-09-08 JP JP2022142901A patent/JP7441907B2/ja active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015268617A1 (en) * | 2010-03-31 | 2016-01-07 | Sividon Diagnostics Gmbh | Method for breast cancer recurrence prediction under endocrine treatment |
| WO2012135397A2 (en) * | 2011-03-29 | 2012-10-04 | Lisanti Michael P | Lactate-and ketones-induced gene signatures and use the same for diagnosing disease and predicting clinical outcome |
| WO2016154600A1 (en) * | 2015-03-25 | 2016-09-29 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
Non-Patent Citations (1)
| Title |
|---|
| 雌激素受体阳性乳腺癌他莫昔芬耐药机制的研究进展;柳慧星等;《肿瘤》;20150925;第35卷(第09期);第1039-1044页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3532642A4 (en) | 2020-06-24 |
| US11371101B2 (en) | 2022-06-28 |
| JP7441907B2 (ja) | 2024-03-01 |
| JP2020501517A (ja) | 2020-01-23 |
| WO2018081625A3 (en) | 2018-06-07 |
| US20220364185A1 (en) | 2022-11-17 |
| EP3532642B1 (en) | 2021-12-08 |
| WO2018081625A2 (en) | 2018-05-03 |
| US12331363B2 (en) | 2025-06-17 |
| JP7195252B2 (ja) | 2022-12-23 |
| JP2022184902A (ja) | 2022-12-13 |
| EP3532642A2 (en) | 2019-09-04 |
| CN110050075A (zh) | 2019-07-23 |
| EP3985127A1 (en) | 2022-04-20 |
| US20190391134A1 (en) | 2019-12-26 |
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