CN110038063A - A kind of drug and preparation method thereof for treating ankylosing spondylitis - Google Patents
A kind of drug and preparation method thereof for treating ankylosing spondylitis Download PDFInfo
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- CN110038063A CN110038063A CN201910482741.0A CN201910482741A CN110038063A CN 110038063 A CN110038063 A CN 110038063A CN 201910482741 A CN201910482741 A CN 201910482741A CN 110038063 A CN110038063 A CN 110038063A
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Abstract
The invention discloses a kind of drugs and preparation method thereof for treating ankylosing spondylitis, its mainly by Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rehmannia glutinosa, rhizoma atractylodis macrocephalae, Poria cocos, cortex cinnamomi, safflower, Radix Salviae Miltiorrhizae, Caulis Spatholobi, fry the drugs such as psoralea corylifolia, evodia rutaecarpa processed, stir-baked RHIZOMA CIBOTII with sand, stir-baked CORTEX EUCOMMIAE, the rhizome of davallia and be prepared according to a certain weight ratio, drug of the present invention has nourishing liver and kidney, curing rheumatism, expelling wind and clearing away cold, relaxing muscles and tendons is calmed the nerves, the function of activating microcirculation and removing stasis medicinal, for treating ankylosing spondylitis short treating period, it is quick, it has no toxic side effect.
Description
Technical field
The present invention relates to a kind of drugs for treating ankylosing spondylitis, belong to the field of Chinese medicines.
Background technique
Ankylosing spondylitis usually starts to fall ill in puberty to one's late 30s, has arthropathy mostly, generally first invades sacrum
Cervical vertebra is developed in ilium joint later, and common sympton includes based on low back pain and morning stiffness, and symptom mitigates after activity, can companion
There are the symptoms such as low-heat, out of strength, appetite stimulator, syntexis, starting pain when morbidity is intermittence, and gradually development is duration later,
Later period pain symptom mitigates, and spine portion or all beginning are tetanic, eventually lead to deformity of spine and lateral bending.Chinese medicine thinks, this
Disease is this void and mark is real, and mainly due to kidney qi loss, tendon and vessel is obstructed, caused by channels and collaterals stasis blocking.Western medical treatment ankylosing spondylitis
The oral drugs such as the sulphur arsenic pyridine of willow nitrogen and leflunomide tablet can only be alleviated, and can not be cured, and the normal phase takes, also secondary containing certain poison
Effect.
Summary of the invention
Therefore, there is greatly expectation and demand to the Chinese medicine of effective treatment ankylosing spondylitis in people, so far for
Only it has not been found that related report about drug of the present invention, the present inventor pass through clinical examination on the basis of hospital handed down from one's ancestors
The research and practice tested develop the drug for the treatment of ankylosing spondylitis, so as to complete the present invention finally.
It is an object of the invention to provide a kind of drugs for treating ankylosing spondylitis.
Another object of the present invention is to provide the preparation methods of the drug.
Drug of the present invention is selection Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rehmannia glutinosa, rhizoma atractylodis macrocephalae, Poria cocos, cortex cinnamomi, safflower, pellet
Ginseng, Caulis Spatholobi fry psoralea corylifolia, evodia rutaecarpa processed, stir-baked RHIZOMA CIBOTII with sand, stir-baked CORTEX EUCOMMIAE, the rhizome of davallia, radix aconiti lateralis preparata, lycopodium calvatum and are combined preparation,
By these pharmaceutical compositions, so that each efficacy of drugs generates synergistic effect, so as to effectively treat the recurrence of ankylosing spondylitis.
Wherein selecting Radix Astragali is because its nature and flavor is sweet, and tepor enters lung, the spleen channel, raw with there is an invigorating qi for consolidating superficies, inducing diuresis for removing edema, eliminating toxic, myogenic
Function controls spontaneous perspiration, night sweat, blood-arthralgia, edema, un-festering of ulcer or prolonged fester before gathering；The toast function of having bowl spares benefit, controls internal injury overstrain, spleen
Empty diarrhea, rectal prolapse, deficiency of vital energy blood is de-, collapses band and the disease of all laboured breathing deficiency of blood.Selecting Radix Codonopsis is because of its nature and flavor sweet and neutral, is started with, foot
Taiyin channels gas point, there is tonifying middle-Jiao and Qi, and the function of promoting the production of body fluid controls weakness of the spleen and the stomach, qi-blood deficiency, and the tired inability of body, deficiency of food is thirsty, chronic diarrhea,
Rectal prolapse.Selecting Radix Angelicae Sinensis is to enter the heart, liver, the spleen channel because of its nature and flavor sweet, acrid, warm, there is a benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizing dryness and lubricating intestine
Function controls irregular menstruation, and menostasis abdominal pain , Disorder lump in the abdomen knot is poly-, metrorrhagia and metrostaxis, headache due to deficiency of blood, dizziness, flaccidity syndrome and arthralgia syndrome, and intestinal dryness difficulty is just, heavy after dysentery with bloody stool,
Ulcer sores, metal-inflicted wound, injury from falling down.Selecting Rhizoma Chuanxiong is to enter liver, gallbladder channel because its nature and flavor is acrid in flavour and warm in nature, there is promote breath and open depression, wind-dispelling is dry
Wet, the function of promoting blood circulation and stopping pain controls air-cooled headache rotation and swoons, hypochondriac pain abdomen pain, arthritis muscle contraction, menostasis, difficult labour, postpartum stasis block pain, carbuncle
Subcutaneous ulcer sore.Selecting Rehmannia glutinosa is because its nature and flavor is sweet, and tepor enters liver and kidney channel, there is enriching yin, the function of enriching blood, and it is few to control deficiency of Yin blood,
Waist knee flaccidity, Cough osteopyrexia, spermatorrhea, metrorrhagia and metrostaxis, irregular menstruation are quenched one's thirst, and number of urinating is deaf, blurred vision.Selecting Rhizoma Atractylodis Macrocephalae is because of its nature and flavor
Bitter sweet, warm enters spleen, stomach meridian, there is a tonifying spleen, beneficial stomach, eliminating dampness, and in function, control deficient QI of the spleen and stomach, do not feel like eating, burnout lacks gas, empty
Swollen, diarrhea, phlegm retention, oedema, jaundice, arthritis with fixed pain caused by dampness, difficult urination is dizzy, spontaneous perspiration, and nausea is uneasy.Selecting Poria cocos is because of its nature and flavor
It is sweet light, it puts down, enters the heart, spleen, lung channel, there is an eliminating dampness and diuresis, beneficial spleen and stomach, the function of antitoxic heart-soothing and sedative controls difficult urination, edema swelling,
Sip and cough, vomiting, diarrhea, spermatorrhea, stranguria with turbid discharge, palpitation with fear, amnesia.Selecting cortex cinnamomi is because of its property acrid-sweet flavor, and heat enters kidney, spleen, wing
Guang warp, there is a supplementing Yuanyang, warming spleen and stomach, removing internal cold, the function of promoting blood circulation, controls the Yang-function insufficiency of kidneyzang, cold weak pulse of limb, yang depletion collapse, and abdominal pain is let out
It rushes down, cold hernia renal mass, waist and knee crymodynia, Jing Bi Disorder lump in the abdomen, negative subcutaneous ulcer, streamer, and empty sun is floating more, heat in the upper and cold in the lower.Selecting safflower is because of it
Nature and flavor are acrid in flavour and warm in nature, enter the heart, Liver Channel, there is blood circulation, the function of stasis eliminatings analgesic, controlling through closing , Disorder lump in the abdomen, difficult labour, stillborn foetus, lochia
Not all right, hemostasis is had a pain, carbuncle swells, injury from falling down.Selecting Radix Salviae Miltiorrhizae is to enter the heart, Liver Channel because of its bitter in taste, tepor, there is blood circulation and promoting silt,
Calming heart and tranquilizing mind, apocenosis, the function of analgesic control angina pectoris, and irregular menstruation, dysmenorrhea, to close, metrorrhagia leukorrhagia , Disorder lump in the abdomen is gathered, hemostasis
Abdominal pain, arthralgia, suspicion, sleeplessness, soreness.Selecting Caulis Spatholobi is to enter the heart, the warp of spleen two because of its sweet, warm bitter in taste, have
It invigorates blood circulation, the function of relaxing muscles and tendons, controls soreness of waist and knee joint, paralysis and numbness, irregular menstruation.Selecting psoralea corylifolia is to enter kidney because its nature and flavor is acrid in flavour and warm in nature
There is the function of tonifying the kidney and support yang, control that kidney deficiency is cold to rush down, the enuresis, spermatorrhoea, frequent urination, impotence, waist and knee crymodynia, cold of insufficiency type asthma coughs, external application
Curing vitiligo.Selecting evodia rutaecarpa is because its nature and flavor is arduous, and temperature is toxic, enters liver, stomach meridian, there is middle benefit gas, is relieved pain, qi-regulating, eliminating dampness
Function controls inverse acid regurgitation of vomitting, jueyin headache, and the cold syndrome in infant is vomited and diarrhoea, abdominal distention, tinea pedis, hernia, aphthous ulcer, dentalgia, eczema, yellow water
Sore.Selecting rhizoma cibotii is to enter liver and kidney channel because of its sweet, warm bitter in taste, there is a nourishing liver and kidney, curing rheumatism, is good for waist foot, the function in sharp joint,
Back ache, goinyalgia flaccidity of lower limbs are controlled, cold-dampness general arthralgia loses and drowns, frequent micturition, spermatorrhea, leukorrhea.Select Cortex Eucommiae be because of the sweet micro-pungent of its nature and flavor,
Temperature enters liver and kidney channel, there is nourishing liver and kidney, strengthening the bones and muscles, and the function of miscarriage prevention controls spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination
Itch, vaginal bleeding during pregnancy is intended to fall, hypertension.Selecting the rhizome of davallia is because its is bitter in taste, and temperature enters liver and kidney channel, there is kidney tonifying, is invigorated blood circulation, the function of hemostasis
Can, control kidney deficiency chronic diarrhea and pain in the loins, rheumatic arthralgia, dentalgia, tinnitus, the bruise sudden strain of a muscle, bone fracture, ecphyaditis, alopecia areata, corn.It selects attached
Son is the heat because of its property acrid-sweet flavor, toxic, enters the heart, spleen, kidney channel, has back sun to mend fiery, the function of dispelling cold and removing dampness, control it is exessive yin refusing yang,
Loss of YANG due to profuse perspiration spits benefit and faints inverse, trusted subordinate's crymodynia, Spleen diarrhea cold dysentery, tinea pedis oedema, infantile chronic fright, chill arthritis with fixed pain caused by dampness, Wei lame muscular constricture, negative subcutaneous ulcer
The disease of sore leakage and all chronic diseases.Selecting lycopodium calvatum is to enter liver, stomach, kidney three because its is bitter in taste acrid in flavour and warm in nature and pass through, have wind-dispelling to dissipate
Cold, dehumidification swelling, the function of relaxing tendons and activating collaterals controls wind-cold-dampness arthralgia, joint pain, numbness of skin, tetraparesis, oedema, bruise damage
Wound.
Specific embodiment
The dosage of drug of the present invention is also the present inventor on the basis of hospital handed down from one's ancestors, and the test passed through repeatedly obtains
, all tool has a better effect the dosage of each drug within the following weight ranges:
45-55 grams of Radix Angelicae Sinensis of 50-65 grams of Radix Codonopsis of 130-160 grams of Radix Astragali
50-65 grams of rhizoma atractylodis macrocephalae of 45-55 grams of Rehmannia glutinosa of 25-35 grams of Rhizoma Chuanxiong
25-35 grams of safflower of 35-45 grams of cortex cinnamomi of 50-65 grams of Poria cocos
45-55 grams of psoralea corylifolia of the stir-fry of 45-55 grams of Caulis Spatholobi of 50-65 grams of Radix Salviae Miltiorrhizae
45-55 grams of stir-baked CORTEX EUCOMMIAE of 80-120 grams of stir-baked RHIZOMA CIBOTII with sand of 45-55 grams of evodia rutaecarpa processed
Rhizome of davallia 45-55 restrains 45-55 grams of lycopodium calvatum of 10-15 grams of monkshood
Preferable amount are as follows:
150 grams of Radix Astragali, 50 grams of Radix Angelicae Sinensis of 60 grams of Radix Codonopsis
30 grams of Rhizoma Chuanxiong, 60 grams of rhizoma atractylodis macrocephalae of 50 grams of Rehmannia glutinosa
60 grams of Poria cocos, 30 grams of safflower of 40 grams of cortex cinnamomi
60 grams of Radix Salviae Miltiorrhizae, 50 grams of Caulis Spatholobi, 50 grams of psoralea corylifolia of stir-fry
50 grams of stir-baked CORTEX EUCOMMIAE of 50 grams of evodia rutaecarpa, 100 grams of stir-baked RHIZOMA CIBOTII with sand processed
The rhizome of davallia 50 restrains 12 grams of monkshood, 50 grams of lycopodium calvatum
The preparation method is as follows:
One, it stocks up
1, Radix Astragali: picking net impurity, removes remaining head and biggish hollow, is soaked in water, pulls out, cut in time after moisturizing
Piece dries；
2, Radix Codonopsis: reed, slice or dissection are moisturized after cleaning silt, is dried；
3, Radix Angelicae Sinensis: picking impurity, cleans, bored profit is slightly dried in the air, and slice dries；
4, Rhizoma Chuanxiong: picking impurity, separates large and small, is soaked in water, and solarization is dried in the air, and is sliced after bored profit, dry；
5, Rehmannia glutinosa: taking crude drug, steams to surface corvinus, takes out, shine to eighty per cant it is dry when, be sliced, it is dry；
6, wheat bran: being first spread in hot pot by rhizoma atractylodis macrocephalae, waits cigarette when emerging, by bighead atractylodes rhizome piece pour into it is micro- fry to faint yellow, take out, weed out
It is cooled after wheat bran (100 jin of every bighead atractylodes rhizome piece, with wheat bran 10 jin)；
7, Poria cocos: being soaked in water, and cleans and pulls out, and after bored, slice is dried；
8, cortex cinnamomi: picking net impurity, scrapes off rough bark, and the used time smashes, or scrapes off rough bark, infiltrates a moment with warm water, slice dries；
9, safflower: picking net impurity, removes cauline leaf, base of a fruit head, dries；
10, Radix Salviae Miltiorrhizae: picking net impurity, removes rhizome, cleans, pulls out, be sliced, dry after moisturizing；
11, Caulis Spatholobi: being moisturized with water, slice, or steam it is soft after be sliced while hot, dry；
12, fry psoralea corylifolia: net psoralea corylifolia being taken to be mixed thoroughly with salt water, micro- profit, set in pot be fried with slow fire it is micro- heave, take out, dry (every
100 jin of psoralea corylifolia, with 2 jin 8 liang of salt, certain amount of boiling water is added to melt clarification)；
13, evodia rutaecarpa processed: extracting liquorice decoction removes slag and takes soup, and net evodia rutaecarpa is added, and is dipped to soup and blots to spend, small fire dries
(100 jin of every evodia rutaecarpa, with Radix Glycyrrhizae 6 jin 4 liang)；
14, it stir-baked RHIZOMA CIBOTII with sand: takes sand to set and fries in pot to light, addition picks net rhizoma cibotii, is fried with high heat to heaving and showing buff, is taken
Out, sand is screened out, after wind dries in the air, hits or scrapes and remove yellow villus；
15, stir-baked CORTEX EUCOMMIAE: first adding certain amount of boiling water to dissolve with salt, takes Cortex Eucommiae block or strand, makes sufficiently to mix absorption with salt water, then
Set in pot, be fried with slow fire it is micro- have focal spot until, (100 jin of every Cortex Eucommiae, with salt 3 jin) is dried in taking-up；
16, the rhizome of davallia: removing sediment contamination, cleans, slightly impregnates, moisturize, and is sliced, dries；
17, radix aconiti lateralis preparata: take salted aconite root clean, clear water impregnate a night, except peeling navel, slice, add water bubble tasted to mouth it is slightly spicy
When sense, take out, soaked 1-3 days with ginger decoction, then cooked, then roast to seventy percent dry, pour into pot use force it is urgent fry to cigarette, micro- drum is split
When, taking-up cools；
18, lycopodium calvatum: weeding out grey bits, picks net impurity, is cut into segment.
Two, it prepares
1, by the Radix Astragali cooked, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rehmannia glutinosa, rhizoma atractylodis macrocephalae, Poria cocos, cortex cinnamomi, safflower, Radix Salviae Miltiorrhizae, Caulis Spatholobi,
Psoralea corylifolia, evodia rutaecarpa processed, stir-baked RHIZOMA CIBOTII with sand, stir-baked CORTEX EUCOMMIAE, the rhizome of davallia, radix aconiti lateralis preparata, lycopodium calvatum is fried to be put into decocting container and add water to cook two
Secondary, for the first time plus water covers drug 4-5cm, impregnates after sixty minutes, and intense fire is fried boiling, then with being cooked by slow fire 60 minutes, filter the
Decoction liquor, the medical fluid of filtering is poured into container；
2, add water to cover drug 3-4cm the dregs of a decoction of filtering, boil by intense fire, then with being cooked by slow fire 50 minutes, filter to obtain second
Decoction liquor；
3, secondary decoction liquor is mixed evenly to obtain the final product, is a consumption per day, is divided into secondary take.
Lycopodium calvatum has expelling wind and clearing away cold, dehumidification swelling in prescription, and the function of relaxing tendons and activating collaterals is monarch drug in a prescription；Rhizoma cibotii nourishing liver and kidney removes wind
It is wet, it is good for waist foot, sharp joint；Radix Salviae Miltiorrhizae has blood circulation and promoting silt, and calming heart and tranquilizing mind, the function of Apocenosis pain relieving, the two is ministerial drug, and three taste medicines are common
Expelling wind and clearing away cold is played, dehumidification swelling, blood circulation and promoting silt, the effect that relaxing muscles and tendons is calmed the nerves, treatment ankylosing spondylitis effect is comprehensive, and to mend
Liver kidney, sharp joint, expelling wind and clearing away cold, activating microcirculation and removing stasis medicinal can effect a permanent cure based on relaxing tendons and activating collaterals；Cortex cinnamomi has a supplementing Yuanyang, warming spleen and stomach, removing internal cold,
The function of promoting blood circulation is adjutant；It is to make medicine that Caulis Spatholobi, which has the function of activating blood and relaxing tendons, is temporary solution with all medicines that is left.
Drug of the present invention has nourishing liver and kidney, curing rheumatism, expelling wind and clearing away cold, relaxing muscles and tendons tranquilizing the mind, the function of activating microcirculation and removing stasis medicinal, for treating
Ankylosing spondylitis short treating period, it is quick, it has no toxic side effect.
The beneficial effect of the present invention will be further illustrated by the following test examples drug, these test examples include medicine of the present invention
The toxicity test of object is reported and clinical observation material.
The toxicity test of [test example 1] drug of the present invention is reported
New zealand rabbit 30 are selected, male and female dual-purpose, weight 2.0-2.5kg is divided into two groups, and every group 15, wherein one group is positive
Constant test group, another group is overdose test group, takes medical fluid of the present invention, normal amount 10ml/kg, super quantity 20ml/
Kg, administration mode are administration by gavage administration, twice daily, even served 7 days, daily observation administration reaction, the results showed that, two groups of rabbit drinks
Food activity is normal, and drug is without bad toxic side effect.
The clinical observation material of [test example 2] drug of the present invention
1, outpatient service records: accepting patients with ankylosing spondylitis 20 for medical treatment, is divided into two groups, every group of 10 people, wherein one group is treatment group, separately
One group is control group.
2, diagnostic criteria: the first symptom of ankylosing spondylitis first is exactly very representational hypnalgia, is slept at night
Feel after, can occur the pain of the small of the back indistinctly at leisure, pain gradually aggravates until pain is awake；Second symptom is exactly
" tetanic " is easy to appear anchylosis, and hip joint was stiff before this, and step is smaller and smaller on foot, is exactly hip joint limited range of motion,
Then when inflammatory development is to backbone, the mobility of backbone can be also limited.
3, treatment method
(1) it selects above-mentioned medical fluid to take to patient, twice a day, 1 dose every time, even served 3-4 weeks；
(2) while medication, in conjunction with dietotherapy, facilitate the curative effect for enhancing drug, improve cure rate, then select following any one
Kind recipe eats partner treatment:
1. ginger chicken: choosing can just be cockerel 1 to ring, and 150-250 grams of ginger, the quick-fried in pot that is cut into small pieces is boiled in a covered pot over a slow fire ripe, not put
Oily salt is added 1 liqueur glass white wine, eats up, eaten in each week once in 1 day, and company eats 3-4 weeks；
2. pilose antler chicken: selecting the cockerel that can have just crowed 1 of current year, 5-8 grams of pilose antler, be put into quick-fried in iron pan and add water bored ripe, no
Oiling salt eats meat and eats soup, and eats up within two days, eats every other week once, company eats 3-4 weeks；
3. rde bean congee: 30 grams of rde bean, 15 grams of rice, 5-6 grams of white sugar, first rde bean is cooked, add rice be cooked into it is small
Beans congee sugaring takes, and once a day, even served 3-4 weeks.
4, efficacy assessment standard
Effective: ankylosing spondylitis shape disappears, and physical recovery is normal；
Improve: night pain in back and loin situation mitigates, and anchylosis phenomenon is alleviated, and body gradually restores normal；
It is invalid: improvement standard person is not achieved.
5, therapeutic effect
Treatment group's oral liquid medicine simultaneously cooperates dietotherapy, as a result effective 6 people, and improve 3 people, invalid 1 people, total effective rate 90%.
The treatment of ankylosing spondylitis is also remained on symptomatic treatment at present, control group intramuscular injection benzathine penicillin,
Cooperate leigongteng tablets treatment 3-4 weeks, as a result effective 3 people, improve 3 people, invalid 4 people, total effective rate 60%.
Claims (4)
1. a kind of drug for treating ankylosing spondylitis, it is characterised in that: it is composed of the bulk drug in the following weight range:
45-55 grams of Radix Angelicae Sinensis of 50-65 grams of Radix Codonopsis of 130-160 grams of Radix Astragali
50-65 grams of rhizoma atractylodis macrocephalae of 45-55 grams of Rehmannia glutinosa of 25-35 grams of Rhizoma Chuanxiong
25-35 grams of safflower of 35-45 grams of cortex cinnamomi of 50-65 grams of Poria cocos
45-55 grams of psoralea corylifolia of the stir-fry of 45-55 grams of Caulis Spatholobi of 50-65 grams of Radix Salviae Miltiorrhizae
45-55 grams of stir-baked CORTEX EUCOMMIAE of 80-120 grams of stir-baked RHIZOMA CIBOTII with sand of 45-55 grams of evodia rutaecarpa processed
Rhizome of davallia 45-55 restrains 45-55 grams of lycopodium calvatum of 10-15 grams of monkshood.
2. drug according to claim 1, wherein the dosage of each bulk pharmaceutical chemicals are as follows:
150 grams of Radix Astragali, 50 grams of Radix Angelicae Sinensis of 60 grams of Radix Codonopsis
30 grams of Rhizoma Chuanxiong, 60 grams of rhizoma atractylodis macrocephalae of 50 grams of Rehmannia glutinosa
60 grams of Poria cocos, 30 grams of safflower of 40 grams of cortex cinnamomi
60 grams of Radix Salviae Miltiorrhizae, 50 grams of Caulis Spatholobi, 50 grams of psoralea corylifolia of stir-fry
50 grams of stir-baked CORTEX EUCOMMIAE of 50 grams of evodia rutaecarpa, 100 grams of stir-baked RHIZOMA CIBOTII with sand processed
The rhizome of davallia 50 restrains 12 grams of monkshood, 50 grams of lycopodium calvatum.
3. the preparation method of drug according to claim 1 or claim 2, it is characterised in that: it includes the following steps:
(1) it stocks up
(1) Radix Astragali: picking net impurity, removes remaining head and biggish hollow, is soaked in water, pulls out, cut in time after moisturizing
Piece dries；
(2) Radix Codonopsis: reed, slice or dissection are moisturized after cleaning silt, is dried；
(3) Radix Angelicae Sinensis: picking impurity, cleans, bored profit is slightly dried in the air, and slice dries；
(4) Rhizoma Chuanxiong: picking impurity, separates large and small, is soaked in water, and solarization is dried in the air, and is sliced after bored profit, dry；
(5) Rehmannia glutinosa: taking crude drug, steams to surface corvinus, takes out, shine to eighty per cant it is dry when, be sliced, it is dry；
(6) wheat bran: being first spread in hot pot by rhizoma atractylodis macrocephalae, and when time cigarette is emerged, bighead atractylodes rhizome piece is poured into micro- fry to faint yellow, taking-up, sieve
It is cooled after removing wheat bran.100 jin of every bighead atractylodes rhizome piece, with 10 jin of wheat bran)；
(7) Poria cocos: being soaked in water, and cleans and pulls out, and after bored, slice is dried；
(8) cortex cinnamomi: picking net impurity, scrapes off rough bark, and the used time smashes, or scrapes off rough bark, infiltrates a moment with warm water, slice dries；
(9) safflower: picking net impurity, removes cauline leaf, base of a fruit head, dries；
(10) Radix Salviae Miltiorrhizae: picking net impurity, removes rhizome, cleans, pulls out, be sliced, dry after moisturizing；
(11) Caulis Spatholobi: being moisturized with water, slice, or steam it is soft after be sliced while hot, dry；
(12) fry psoralea corylifolia: net psoralea corylifolia being taken to be mixed thoroughly with salt water, micro- profit, set in pot be fried with slow fire it is micro- heave, take out, dry,
100 jin of every psoralea corylifolia adds certain amount of boiling water to melt clarification with 2 jin 8 liang of salt；
(13) evodia rutaecarpa processed: extracting liquorice decoction removes slag and takes soup, and net evodia rutaecarpa is added, and is dipped to soup and blots as degree, small fire roasting
It is dry, 100 jin of every evodia rutaecarpa, with 6 jin 4 liang of Radix Glycyrrhizae；
(14) stir-baked RHIZOMA CIBOTII with sand: taking sand to set and fry in pot to light, and addition picks net rhizoma cibotii, is fried with high heat to heaving and show buff,
It takes out, screens out sand, after wind dries in the air, hit or scrape and remove yellow villus；
(15) stir-baked CORTEX EUCOMMIAE: first adding certain amount of boiling water to dissolve with salt, takes Cortex Eucommiae block or strand, makes sufficiently to mix absorption with salt water, so
In postposition pot, be fried with slow fire it is micro- have focal spot until, taking-up is dried, 100 jin of every Cortex Eucommiae, with 3 jin of salt；
(16) rhizome of davallia: removing sediment contamination, cleans, slightly impregnates, moisturize, and is sliced, dries；
(17) radix aconiti lateralis preparata: take salted aconite root clean, clear water impregnate a night, except peeling navel, slice, add water bubble tasted to mouth it is slightly spicy
When sense, take out, soaked 1-3 days with ginger decoction, then cooked, then roast to seventy percent dry, pour into pot use force it is urgent fry to cigarette, micro- drum is split
When, taking-up cools；
(18) lycopodium calvatum: weeding out grey bits, picks net impurity, is cut into segment；
(2) it prepares
(1) by the Radix Astragali cooked, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rehmannia glutinosa, rhizoma atractylodis macrocephalae, Poria cocos, cortex cinnamomi, safflower, Radix Salviae Miltiorrhizae, chicken blood
Rattan fries psoralea corylifolia, evodia rutaecarpa processed, stir-baked RHIZOMA CIBOTII with sand, stir-baked CORTEX EUCOMMIAE, the rhizome of davallia, radix aconiti lateralis preparata, lycopodium calvatum and is put into decocting container and adds water to cook
Secondary, for the first time plus water covers drug 4-5cm, impregnates after sixty minutes, intense fire is fried boiling, then with being cooked by slow fire 60 minutes, filters
First time decoction liquor pours into the medical fluid of filtering in container；
(2) add water to cover drug 3-4cm the dregs of a decoction of filtering, boil by intense fire, then with being cooked by slow fire 50 minutes, filter to obtain second
Decoction liquor；
(3) secondary decoction liquor is mixed evenly to obtain the final product, is a consumption per day, is divided into secondary take.
4. drug according to claim 1 or 2, it is characterised in that: it includes the recipe of following dietotherapies, in the same of medication
When, in conjunction with dietotherapy, facilitate the curative effect for enhancing drug, improve cure rate, then selects following edible cooperations of any recipe
Treatment:
1. ginger chicken: choosing can just be cockerel 1 to ring, and 150-250 grams of ginger, the quick-fried in pot that is cut into small pieces is boiled in a covered pot over a slow fire ripe, not put
Oily salt is added 1 liqueur glass white wine, eats up, eaten in each week once in 1 day, and company eats 3-4 weeks；
2. pilose antler chicken: selecting the cockerel that can have just crowed 1 of current year, 5-8 grams of pilose antler, be put into quick-fried in iron pan and add water bored ripe, no
Oiling salt eats meat and eats soup, and eats up within two days, eats every other week once, company eats 3-4 weeks；
3. rde bean congee: 30 grams of rde bean, 15 grams of rice, 5-6 grams of white sugar, first rde bean is cooked, add rice be cooked into it is small
Beans congee sugaring takes, and once a day, even served 3-4 weeks.
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|---|---|---|---|---|
| CN110840981A (en) * | 2019-12-13 | 2020-02-28 | 吕峰展 | Medicine for treating lumbar prolapse and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1403139A (en) * | 2002-10-08 | 2003-03-19 | 李德邦 | Externally applied Chinese medicine for treating osteoarthropathy and its prepn process |
-
2019
- 2019-06-04 CN CN201910482741.0A patent/CN110038063A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1403139A (en) * | 2002-10-08 | 2003-03-19 | 李德邦 | Externally applied Chinese medicine for treating osteoarthropathy and its prepn process |
Non-Patent Citations (2)
| Title |
|---|
| 苏小军等: "《新编中医内科学》", 30 June 2018 * |
| 陈志军等: "中医辨证分型治疗强直性脊柱炎疗效观察", 《中国临床康复》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110840981A (en) * | 2019-12-13 | 2020-02-28 | 吕峰展 | Medicine for treating lumbar prolapse and preparation method thereof |
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Application publication date: 20190723 |