CN110031620B - Pre-uncovering device and chemiluminescence immunoassay analyzer - Google Patents

Pre-uncovering device and chemiluminescence immunoassay analyzer Download PDF

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Publication number
CN110031620B
CN110031620B CN201910375745.9A CN201910375745A CN110031620B CN 110031620 B CN110031620 B CN 110031620B CN 201910375745 A CN201910375745 A CN 201910375745A CN 110031620 B CN110031620 B CN 110031620B
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opening
cover
reagent
evaporation
driving
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CN110031620A (en
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蒋中伟
戴文东
赵建平
程素广
韩红伟
朱剑焕
张品良
陈琦
王史杰
吴晓明
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Shanghai Aopu Biomedical Co ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
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  • Biomedical Technology (AREA)
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  • Food Science & Technology (AREA)
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  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention relates to a pre-opening device and a chemiluminescence immunoassay analyzer. The pre-cover-opening device is used for pre-opening a cover of a container with an anti-evaporation cover, and comprises an opening portion and a driving portion, wherein the opening portion is provided with a through hole which vertically extends, the through hole is used for a sampling needle to pass through, so that the sampling needle can open the opening portion to open the anti-evaporation cover and then enter the container for sampling, the driving portion is connected with the opening portion, and the driving portion can drive the opening portion to move along the axial direction of the container to open the anti-evaporation cover. The pre-uncovering device can pre-uncover a container with an anti-evaporation cover, so that misjudgment of the liquid level detection device in the process that the sampling needle penetrates through the anti-evaporation cover is avoided, and the success rate of sampling can be improved.

Description

Pre-uncovering device and chemiluminescence immunoassay analyzer
Technical Field
The invention relates to the field of in-vitro detection medical instruments, in particular to a pre-opening device and a chemiluminescence immunoassay analyzer with the same.
Background
The chemiluminescence immunoassay analyzer is a novel labeled immunoassay instrument which combines chemiluminescence with immunoreaction and is used for detecting trace antigens or antibodies. Since most reagents need to be protected against evaporation, it is necessary to equip the reagent bottles containing the reagents with an evaporation-proof cap, and it is therefore necessary to solve the problem of sampling through the evaporation-proof cap. As shown in fig. 1, an evaporation prevention cover 101 is provided at a bottle mouth of the reagent bottle 10, and the evaporation prevention cover 101 is formed by splicing a plurality of fan-shaped pieces.
The existing analyzer samples a reagent bottle with an evaporation-proof cover, mainly loads a liquid level detection device on a manipulator, and directly utilizes a reagent needle to penetrate the evaporation-proof cover for sampling. In this process, when the reagent needle passes through the evaporation prevention cover with the liquid drop, the liquid level detection device may misjudge that the sampling needle has been inserted into the reagent, and the manipulator stops driving the reagent needle to move, thereby causing sampling failure.
Furthermore, the use of either an anti-evaporative cover or an improved level detection means results in substantial cost and cycle time for retrofitting.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, an object of the present invention is to provide a pre-opening device for pre-opening a container having an evaporation-proof cover and a chemiluminescent immunoassay analyzer having the pre-opening device.
Therefore, the invention provides the following technical scheme.
The invention provides a pre-opening cover device, which is used for pre-opening a cover of a container with an anti-evaporation cover and comprises an opening part and a driving part,
the through-hole that vertical extension set up is seted up to the portion of strutting, the through-hole is used for supplying the sampling needle to pass, makes the sampling needle can the portion of strutting struts get into behind the evaporation prevention lid the container sample, drive division with the portion of strutting is connected, drive division can drive the portion of strutting is followed the axial displacement of container is in order to strut the evaporation prevention lid.
In at least one embodiment, the pre-opening cover device further comprises a fixing guide portion, the fixing guide portion comprises a fixing seat, one of the fixing seat and the opening portion is vertically provided with a guide post, the other one of the fixing seat and the opening portion is provided with a guide hole, and the guide post is inserted into the guide hole to guide the opening portion in the vertical direction.
In at least one embodiment, an elastic return mechanism is provided between the expanding portion and the fixed seat, one end of the elastic return mechanism is connected to the expanding portion, and the other end of the elastic return mechanism is connected to the fixed seat, and the elastic return mechanism is configured to return the expanding portion away from the container after the external driving force applied to the expanding portion is removed by the driving portion.
In at least one embodiment, the distracting portion includes a pressure plate and a plurality of distracting blocks, the pressure plate is coupled to the drive portion,
the plurality of the strutting blocks are arranged on the pressure plate in an extending way along the vertical direction,
the driving part can drive the pressing plate to drive the opening block to move together along the axial direction of the container.
In at least one embodiment, the elastic return mechanism is a return spring, the return spring is sleeved on at least one of the opening blocks, and the at least one opening block is arranged to penetrate through the fixed seat.
In at least one embodiment, the pre-uncovering device further comprises a propping detection sensor, the propping portion is provided with a propping detection block, and the propping detection block is detected by the propping detection sensor to determine whether the propping portion props the evaporation-proof cover.
In at least one embodiment, the driving part comprises a driving motor, a ball screw, a transmission rod and a hinge seat,
the driving motor, the ball screw and the transmission rod are sequentially connected in a transmission way,
one end of the transmission rod is connected with the ball screw, the other end of the transmission rod is connected with the opening portion, and the portion, located between the one end and the other end, of the transmission rod is hinged to the hinge seat.
The invention also provides a chemiluminescent immunoassay analyzer which comprises the pre-uncapping device in any one of the above embodiments.
In at least one embodiment, the chemiluminescent immunoassay analyzer comprises a reagent bin, the container is a reagent bottle which is placed in the reagent bin and is used for containing a reagent,
the reagent bin comprises a reagent bin cover, the opening part is arranged on the reagent bin cover in a way of penetrating through the reagent bin cover,
the driving part can drive the propping part to vertically move downwards relative to the reagent bin cover so as to prop open the evaporation-proof cover of the reagent bottle.
In at least one embodiment, the reagent cartridge cover comprises a bottom cover and a top cover, the spreader is disposed through the bottom cover,
the top cover is provided with a first opening part and a second opening part,
the first opening portion is opposed to the through hole in a vertical direction so that the sampling needle can enter the through hole through the first opening portion,
one of the driving portion and the expanding portion is connected to the other of the driving portion and the expanding portion through the second opening portion.
By adopting the technical scheme, the cover pre-opening device is provided, the opening part and the driving part are arranged, the driving part can drive the opening part to vertically move, the container with the evaporation-proof cover is pre-opened, the liquid level detection device is prevented from being misjudged in the process that the sampling needle penetrates through the evaporation-proof cover, and the sampling success rate can be improved.
It will be appreciated that a chemiluminescent immunoassay analyzer having the pre-lidding device has the same benefits.
Drawings
Fig. 1 is a perspective view showing a prior art reagent bottle with an evaporation prevention cap.
Fig. 2 shows a perspective view of a pre-capping device according to the present invention.
Fig. 3 is a perspective view showing the expanding portion and the fixing guide portion in fig. 2.
Fig. 4 shows a schematic structural view of the distraction portion, the fixing base, the return spring, and the distraction detection sensor in fig. 3.
Fig. 5 is a schematic view showing an angle structure of the expanding portion and the return spring in fig. 4.
Fig. 6 shows a schematic view of another angle of the distracting part and the return spring in fig. 4.
Fig. 7 shows a schematic structural view of the fixing base and the distraction detection sensor in fig. 4.
Fig. 8 shows a schematic structural view of the cover plate in fig. 3.
Fig. 9 shows a partial structural view of the driving part in fig. 2.
Description of the reference numerals
10 reagent bottles; 101 an anti-evaporation cover;
1 a distraction section; 11, pressing a plate; 12 a distraction block; 121 through holes; 13 a guide hole; 14 a connecting part; 15, opening the detection block;
2 fixing the guide part; 21 a fixed seat; 211 a guide post; 212 a stepped bore; 22 a cover plate; 221 a first opening portion; 222 a second opening portion;
3 a driving part; 31 a drive motor; 32 ball screws; 33 a transmission connection plate; 331 grooves; 34 a transmission rod; 35 a hinged seat;
4, a return spring;
5 distracting the detection sensor; 51 detect the trough.
Detailed Description
Exemplary embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood that the detailed description is only intended to teach one skilled in the art how to practice the invention, and is not intended to be exhaustive or to limit the scope of the invention.
"connected" as referred to in the present invention is not limited to a direct connection but includes an indirect connection; the connecting device is not limited to fixed connecting modes such as connecting through a fastener, clamping, welding and integral forming, but also comprises movable connecting modes such as abutting connection and sliding connection.
A detailed description of an embodiment of the pre-opening device according to the present invention will be given below with reference to fig. 2 to 9.
In the present embodiment, as illustrated in fig. 2 and 4, the pre-opening device according to the present invention includes a spreader portion 1, a fixed guide portion 2, a driving portion 3, a return spring 4, and a spreader detection sensor 5. The driving unit 3 is connected to the expanding unit 1, and the driving unit 3 can drive the expanding unit 1 to move in a vertical direction (i.e., an axial direction of the reagent bottle 10 in the present embodiment) to expand the evaporation preventing cover 101 of the reagent bottle 10.
In the present embodiment, as shown in fig. 3 to 6, the distraction section 1 includes a pressure plate 11, a distraction block 12, a guide hole 13, a connection portion 14, and a distraction detection block 15.
In the present embodiment, as shown in fig. 5 and 6, a spreader block 12 having a substantially cylindrical shape as a whole is fixedly provided on the pressure plate 11 so as to extend in the vertical direction, and the spreader block 12 has a through hole 121 extending vertically, and the through hole 121 is used for a reagent needle (sampling needle) to pass through so as to enter the reagent bottle 10. In this embodiment, there are three spreading blocks 12, and thus the three reagent bottles 10 can be simultaneously pre-opened.
The guide hole 13 is opened through the platen 11 and the connecting portion 14. In the present embodiment, there are two guide holes 13.
A connecting portion 14 having a rectangular parallelepiped shape as a whole is fixedly provided on the upper surface of the platen 11, and is brought into contact with the driving portion 3.
The distraction detection block 15 extends from the side of the pressure plate 11 away from the pressure plate 11.
In the present embodiment, as shown in fig. 3, 7 and 8, the fixing guide 2 includes a fixing base 21 and a cover plate 22. Wherein, the fixed seat 21 and the cover plate 22 are fixedly connected.
In the present embodiment, as shown in fig. 7, the fixed base 21 is provided with a guide post 211 and a stepped hole 212.
The guide posts 211 are two, and the two guide posts 211 are respectively inserted into the corresponding guide holes 13.
The stepped holes 212 are three, and the three spreading blocks 12 are respectively inserted into the corresponding stepped holes 212 through the fixing base 21. Wherein, the diameter of the hole with smaller diameter in the stepped hole 212 is slightly larger than the diameter of the spreading block 12.
In the present embodiment, as shown in fig. 8, the cover plate 22 has a first opening 221 and a second opening 222.
In the present embodiment, the first opening portion 221 has a circular shape, there are three first opening portions 221, and the three first opening portions 221 and the three through holes 121 respectively correspond one-to-one in the vertical direction, so that the reagent needles can enter the through holes 121 through the first opening portions 221.
In the present embodiment, as shown in fig. 3 and 8, the second opening portion 222 has a rectangular shape, and the connection portion 14 partially protrudes into the second opening portion 222 so that the driving portion 3 can be connected to the connection portion 14.
In the present embodiment, as shown in fig. 2 and 9, the driving part 3 includes a driving motor 31, a ball screw 32, a transmission connecting plate 33, a transmission lever 34, and a hinge base 35.
In the present embodiment, the driving motor 31 is connected to the ball screw 32 in a driving manner, one end of the driving connection plate 33 is fixedly connected to the nut of the ball screw 32, and the other end is provided with the concave groove 331.
In the present embodiment, as shown in fig. 2 and 9, one end of the transmission rod 34 is disposed in the recess 331, and the other end is connected to (e.g., abuts) the connecting portion 14, and the middle portion of the transmission rod 34 is hinged with the hinge seat 35.
In the present embodiment, when the driving motor 31 drives the transmission connecting plate 33 to move upward, the transmission rod 34 rotates around the hinge axis with the hinge seat 35, one end of the transmission rod 34 slides in the groove 331, and the other end presses the connecting portion 14, so that the distracting portion 1 moves vertically downward.
In the present embodiment, as shown in fig. 4, 5 and 6, the return spring 4 is fitted to the expanding block 12, and one end of the return spring 4 abuts against the pressing plate 11 and the other end abuts against the fixed base 21. The return spring 4 is used to return the expanding portion 1 after the driving portion 3 removes the external driving force applied to the expanding portion 1. Wherein the lower part of the return spring 4 extends into the larger diameter hole of the stepped hole 212.
In the present embodiment, as shown in fig. 4 and 7, the distraction detection sensor 5 is provided on the fixed base 21, and the distraction detection sensor 5 has a detection groove 51.
When the opening part 1 opens the evaporation-proof cover 101 of the reagent bottle 10 in place, the opening detection block 15 just moves into the detection groove 51, the opening detection sensor 5 detects the opening detection block 15 and can send an opening in-place signal to the control device, and the control device controls the driving part to stop driving the opening part 1 after receiving the opening in-place signal.
It is understood that in the present embodiment, the fixed guide 2 and the reagent bottle 10 may be fixed, and the spreading part 1 is moved relative to the fixed guide 2 and the reagent bottle 10 by the driving of the driving part 3.
The operation of the pre-opening device according to the present invention will be explained.
In the present embodiment, when a sample needs to be taken from the reagent bottle 10, the control device controls the driving unit 3 to drive the expanding unit 1 to move vertically downward, and after the expanding unit 1 moves downward to expand the evaporation-preventing cover 101 of the reagent bottle 10, the control device receives the expanding in-place signal from the expanding detection sensor 5, and the control device controls the driving unit 3 to stop driving the expanding unit 1.
At this time, the control device may control the movement of the sampling robot such that the reagent needle passes through the through hole 121 to enter the reagent bottle 10 for sampling.
After sampling, the control device can control the driving part 3 to reset, and the opening part 1 resets under the action of the reset spring 4 to wait for next sampling.
By adopting the technical scheme, the pre-opening device at least has the following advantages:
(1) In the pre-cap-opening device, the driving part can drive the opening part to vertically move to pre-open the anti-evaporation cap of the reagent tube by arranging the opening part and the driving part, so that the liquid level detection device is prevented from misjudging in the process that the reagent needle passes through the anti-evaporation cap, and the success rate of sampling can be improved.
(2) In the lid pre-opening device of the present invention, a plurality of reagent tubes can be simultaneously sampled by providing a plurality of spreading pieces.
(3) In the pre-opening cover device, the fixed guide part is arranged, so that the opening part can move more stably to open the evaporation-proof cover.
(4) In the pre-opening device, the reset spring is arranged, so that the opening part can be automatically reset, and the pre-opening device is simple in structure.
(5) In the pre-cap opening device, the opening detection sensor is arranged, so that the moving position of the opening block can be accurately detected, and the working accuracy of the pre-cap opening device is improved.
The technical solution of the present invention is explained in detail in the above specific embodiments, but it should be additionally noted that:
(1) Although it is described in the above embodiment that the number of the expanding blocks is three, the present invention is not limited thereto, and the number of the expanding blocks may be one, two, four or more, and it is understood that the number of the stepped holes should be the same as the number of the expanding blocks.
(2) Although it is described in the above-described embodiment that the number of the guide posts and the guide holes is two, the present invention is not limited thereto, and the number of the guide posts and the guide holes may be one, three, or more.
(3) Although the guide post is provided in the fixing base and the guide hole is opened in the pressing plate and the connecting portion in the above embodiment, the present invention is not limited thereto, and the guide post may be provided in the pressing plate and the guide hole may be opened in the fixing base accordingly.
(4) Although the detection groove is provided in the distraction detection sensor to detect the distraction detection block in the above embodiment, the present invention is not limited to this, and a micro switch, for example, may be used to detect the distraction detection block.
(5) Although the above embodiment describes that the return spring is sleeved on the expanding block, the present invention is not limited thereto, and the return spring may be sleeved on the guide post, or may be directly disposed between the pressing plate and the fixing base without being sleeved on the expanding block or the guide post.
(6) Although the above-described embodiment has been described as providing the return spring to return the distracting portion, the present invention is not limited to this, and other types of elastic return mechanisms may be provided to return the distracting portion, and the distracting portion may be controlled to reciprocate up and down directly by the driving portion without providing the return spring.
(7) The reagent bottle mentioned in the above embodiment may be another container with an evaporation-proof cap.
(8) The driving unit in the above embodiment may be a driving cylinder or other driving mechanism as long as the driving unit can drive the expanding unit to move in the vertical direction.
(9) In the above embodiment, the fixing guide portion may not be provided according to actual circumstances.
(10) The shapes of the first opening portion and the second opening portion in the above embodiments are not limited to the circular shape and the rectangular shape, and the first opening portion and the second opening portion may be integrally connected.
In addition, the invention also provides a chemiluminescence immunoassay analyzer which comprises the pre-uncovering device. The chemiluminescence immunoassay analyzer comprises a reagent bin, and a reagent bin cover of the reagent bin comprises a bottom cover and a top cover. An insulating material is usually arranged between the bottom cover and the top cover so as to keep a certain temperature in the reagent cabin.
In this embodiment, the pre-opening device may be directly and integrally disposed above the reagent chamber cover, i.e., the fixing base 21 is located at the upper portion of the top cover.
In addition, a part of the bottom cover may be used as the fixing seat 21, a part of the top cover may be used as the cover plate 22, the pressing plate 11 is located between the bottom cover and the top cover, and the expanding block 12 is disposed through the bottom cover. Therefore, the space occupied by the pre-uncovering device can be reduced, and the overall structure of the chemiluminescence immunoassay analyzer is simplified.

Claims (8)

1. A pre-opening lid device for pre-opening a lid of a container with an anti-evaporation lid (101), characterized in that the pre-opening lid device comprises a spreader (1) and a driver (3),
the opening part (1) is provided with a through hole (121) which is vertically extended, the through hole (121) is used for a sampling needle to pass through, so that the sampling needle can enter the container for sampling after the opening part (1) opens the evaporation-proof cover (101), the opening part (1) comprises a pressing plate (11) and at least one opening block (12), the pressing plate (11) is connected with the driving part (3),
the propping block (12) is arranged on the pressure plate (11) in a manner of extending along the vertical direction, the propping block (12) can move to prop open the evaporation-proof cover (101),
the driving part (3) is connected with the strutting part (1), the driving part (3) can drive the strutting part (1) to move along the axial direction of the container so as to strut the evaporation-proof cover (101),
the pre-uncovering device further comprises a fixed guide part (2), the fixed guide part (2) comprises a fixed seat (21), one of the fixed seat (21) and the opening part (1) is vertically provided with a guide post (211), the other one is provided with a guide hole (13), the guide post (211) is inserted into the guide hole (13) to guide the opening part (1) in the vertical direction,
an elastic reset mechanism is arranged between the opening part (1) and the fixed seat (21), one end of the elastic reset mechanism is connected with the opening part (1), the other end is connected with the fixed seat (21),
the elastic reset mechanism is used for enabling the expansion part (1) to be reset after the driving part (3) removes the external driving force applied to the expansion part (1) and then the expansion part (1) is separated from the container.
2. Pre-uncapping device according to claim 1, wherein the distracting portion (1) comprises a plurality of distracting blocks (12),
the driving part (3) can drive the pressing plate (11) to drive the opening block (12) to move together along the axial direction of the container.
3. The pre-opening device according to claim 2, wherein the elastic return mechanism is a return spring (4), the return spring (4) is sleeved on at least one of the opening blocks (12), and the at least one opening block (12) is arranged to penetrate through the fixing seat (21).
4. The pre-opening cover device according to claim 1, characterized in that the pre-opening cover device further comprises a spreading detection sensor (5), the spreading portion (1) is provided with a spreading detection block (15), and whether the spreading portion (1) has spread the evaporation-proof cover (101) is judged by detecting the spreading detection block (15) through the spreading detection sensor (5).
5. Pre-opening device according to claim 1, characterized in that the drive (3) comprises a drive motor (31), a ball screw (32), a transmission rod (34) and a hinge seat (35),
the driving motor (31), the ball screw (32) and the transmission rod (34) are sequentially in transmission connection,
one end of the transmission rod (34) is connected with the ball screw (32), the other end of the transmission rod is connected with the opening part (1), and the part, located between the one end and the other end, of the transmission rod (34) is hinged to the hinge seat (35).
6. A chemiluminescent immunoassay analyzer comprising the pre-lidding device of any one of claims 1 to 5.
7. The chemiluminescent immunoassay analyzer of claim 6, comprising a reagent compartment, the container being a reagent bottle (10) for containing a reagent placed in the reagent compartment,
the reagent bin comprises a reagent bin cover, the opening part (1) penetrates through the reagent bin cover and is arranged on the reagent bin cover,
the driving part (3) can drive the propping part (1) to vertically move downwards relative to the reagent bin cover so as to prop open the evaporation-proof cover (101) of the reagent bottle (10).
8. The chemiluminescent immunoassay analyzer of claim 7, wherein the reagent cartridge cover comprises a bottom cover and a top cover, the spreading portion (1) being disposed through the bottom cover,
the top cover is provided with a first opening part and a second opening part,
the first opening portion is opposed to the through-hole (121) in a vertical direction so that the sampling needle can enter the through-hole (121) through the first opening portion,
one of the driving part (3) and the spreading part (1) is connected to the other through the second opening.
CN201910375745.9A 2019-05-07 2019-05-07 Pre-uncovering device and chemiluminescence immunoassay analyzer Active CN110031620B (en)

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CN201910375745.9A CN110031620B (en) 2019-05-07 2019-05-07 Pre-uncovering device and chemiluminescence immunoassay analyzer

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Application Number Priority Date Filing Date Title
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CN110031620B true CN110031620B (en) 2022-10-25

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