CN110013540A - A kind of Chinese medicine composition and its preparation method and application increasing gastrointestinal bacterial flora - Google Patents
A kind of Chinese medicine composition and its preparation method and application increasing gastrointestinal bacterial flora Download PDFInfo
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- CN110013540A CN110013540A CN201910417393.9A CN201910417393A CN110013540A CN 110013540 A CN110013540 A CN 110013540A CN 201910417393 A CN201910417393 A CN 201910417393A CN 110013540 A CN110013540 A CN 110013540A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The present invention provides a kind of Chinese medicine compositions and its preparation method and application for increasing gastrointestinal bacterial flora, are related to field of Chinese medicinal composition.The raw material of the Chinese medicine composition includes 5-20 parts of dried orange peel, 3-12 parts of the coptis, 6-20 parts of evodia rutaecarpa according to parts by weight, 3-12 parts of rhizoma zingiberis, 5-20 parts of the tuber of pinellia, 3-15 parts of cimicifugae foetidae, burnt dark plum 5-20 parts, 5-20 parts of Schisandra chinensis, 5-20 parts of charred FRUCTUS CRATAEGI, 5-20 parts of charred RADIX SANGUISORBAE, 5-30 parts of hairyvein agrimony, it is 5-20 parts of the bark of ash, 5-20 parts windproof.Preparation method is simple, and medicament is mixed and made into after raw material is crushed, and the medicament of acquisition can be used for treating and preventing and treating alimentary canal chronic disease.By carrying out compatibility to various Chinese medicine materials in the application, can its can utilize drug matching, start with from intestinal flora is adjusted, to treat and disease preventing and treating, there is good efficacy.
Description
Technical field
The present invention relates to field of Chinese medicinal composition, specifically, providing a kind of Chinese traditional medicine composition for increasing gastrointestinal bacterial flora
Object and its preparation method and application.
Background technique
Intestinal flora, the microflora of human body intestinal canal, such as Bifidobacterium, Bacillus acidi lactici etc. can synthesize a variety of growth in humans
Necessary vitamin is developed, such as B family vitamin (vitamin B1、B2、B6、B12), vitamin K, niacin, pantothenic acid etc., moreover it is possible to utilize egg
White matter residue synth essential amino acid, such as asparagus fern door propylhomoserin, phenylalanine, valine and threonine, and participate in carbohydrate and egg
The metabolism of white matter, while the absorption of the mineral elements such as iron, magnesium, zinc can also be promoted.These nutriments have the health of the mankind
Important function, once a variety of diseases can be caused by lacking.
For increasing the mode of gastrointestinal bacterial flora, the base-forming food containing dietary fiber can be fed more, can also be supplemented micro-
Such as ecological viable bacteria element of ecological agent, Bifidobacterium or stachyose, preferably adjust the health of enteral Tiny ecosystem.But at present
Increase gastrointestinal bacterial flora not in the way of Chinese medicine composition.
Summary of the invention
This application provides a kind of Chinese medicine compositions for increasing gastrointestinal bacterial flora, drug matching can be utilized, from adjusting
Intestinal flora is started with, and to treat and disease preventing and treating, clinic has good efficacy.
The application also provides a kind of preparation method for Chinese medicine composition for increasing gastrointestinal bacterial flora that comes, preparation method letter
Single, operation is easy.
The embodiment of the present invention is achieved in that
The embodiment of the invention provides a kind of Chinese medicine composition for increasing gastrointestinal bacterial flora, raw material wraps according to parts by weight
Include 5-20 parts of dried orange peel, 3-12 parts of the coptis, 6-20 parts of evodia rutaecarpa, 3-12 parts of rhizoma zingiberis, 5-20 parts of the tuber of pinellia, 3-15 parts of cimicifugae foetidae, burnt dark plum
5-20 parts, 5-20 parts of Schisandra chinensis, 5-20 parts of charred FRUCTUS CRATAEGI, 5-20 parts of charred RADIX SANGUISORBAE, 5-30 parts of hairyvein agrimony, 5-20 parts of the bark of ash, windproof 5-
20 parts.
The embodiment of the invention also provides a kind of preparation methods of Chinese medicine composition for increasing gastrointestinal bacterial flora comprising will
Raw material is mixed and made into medicament after crushing.
The embodiment of the invention also provides a kind of Chinese medicine compositions for increasing gastrointestinal bacterial flora to treat and prevent and treat alimentary canal
Application in the drug of chronic disease, alimentary canal chronic disease include atrophic, non-atrophic gastritis, gastric ulcer, stomach gruel
One of rotten, ulcerative colitis, chronic enteritis, constipation, irritable bowel syndrome and depression are a variety of.
The beneficial effect of the embodiment of the present invention for example,
By carrying out compatibility to various Chinese medicine materials in the application, dried orange peel and cimicifugae foetidae compatibility can be played into reducing phlegm and resolving masses
Effect, in addition, dried orange peel and cimicifugae foetidae all have the effect of certain inhibition fungi, and its can promote Bifidobacterium and lactobacillus this
The growth of class beneficial bacteria of intestinal tract inhibits Escherichia coli and treats alimentary canal chronic disease.Simultaneously by the roughly the same coptis of channel tropism, Wu
The fruit of medicinal cornel, rhizoma zingiberis and the tuber of pinellia are compounded, this can be mutually coordinated, further promote antibacterial effect, and can heat-clearing it is dry
The effect of wet, eliminating cold to stop pain and supporing yang antidiarrheal, beneficial bacteria of intestinal tract can be adjusted.Burnt dark plum and Schisandra chinensis can hold back negative tonifying yin.It is burnt
Hawthorn being capable of promoting digestion and removing indigestion.Charred RADIX SANGUISORBAE, hairyvein agrimony can restrain, are anti-inflammatory, improving body's immunity.The bark of ash and radix saposhnikoviae can be clear
Hot eliminating dampness, clear wind-heat of liver channel.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
The Chinese medicine composition and preparation method thereof of the increase gastrointestinal bacterial flora of the embodiment of the present invention is carried out specifically below
It is bright.
The embodiment of the invention provides a kind of Chinese medicine composition for increasing gastrointestinal bacterial flora, raw material wraps according to parts by weight
Include 5-20 parts of dried orange peel, 3-12 parts of the coptis, 6-20 parts of evodia rutaecarpa, 3-12 parts of rhizoma zingiberis, 5-20 parts of the tuber of pinellia, 3-15 parts of cimicifugae foetidae, burnt dark plum
5-20 parts, 5-20 parts of Schisandra chinensis, 5-20 parts of charred FRUCTUS CRATAEGI, 5-20 parts of charred RADIX SANGUISORBAE, 5-30 parts of hairyvein agrimony, 5-20 parts of the bark of ash, windproof 5-
20 parts.
Wherein, dried orange peel and cimicifugae foetidae can play reducing phlegm and resolving masses, the two compatibility, ascending the clear and descending the turbid, and spleen sun must rise, and stomach Qi must drop.
The coptis, evodia rutaecarpa, rhizoma zingiberis and the tuber of pinellia, it is pungent to open bitter drop, cold temperature and adjust, clearing away damp-heat, tonifying spleen and kidney yang-energy.Coptis return heart, spleen, stomach,
Liver, gallbladder, large intestine channel.Evodia rutaecarpa returns liver, spleen, stomach, kidney channel.Rhizoma zingiberis also returns spleen, stomach, kidney, the heart, lung channel, tuber of pinellia returns spleen, stomach, lung channel.
Can be seen that this from this channel tropism can be mutually coordinated, and being capable of heat-clearing and damp-drying drug, eliminating cold to stop pain and supporing yang antidiarrheal
The effect of, beneficial bacteria of intestinal tract can be adjusted.Burnt dark plum and Schisandra chinensis can hold back negative tonifying yin.Charred FRUCTUS CRATAEGI being capable of promoting digestion and removing indigestion.Garden burnet
Charcoal, hairyvein agrimony can restrain, are anti-inflammatory, improving body's immunity.The bark of ash and radix saposhnikoviae can heat-clearing and damp-drying drug, clear wind-heat of liver channel.
In the application, above-mentioned Chinese medicine material combination is used, it can be by adjusting beneficial bacteria of intestinal tract, thus treatment and prevention and treatment
Disease.
In addition, the raw material of the application is according to parts by weight further include: 10-30 parts of Radix Astragali, 10-20 parts of Radix Codonopsis, Rhizoma Atractylodis Macrocephalae 10-20
Part, 10-20 parts of Poria cocos, 5-20 parts of Radix Angelicae Sinensis, 5-20 parts of jujube.
Wherein, Radix Astragali can enhance body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and wide
Antibacterial action；Radix Codonopsis has strengthen immunity, expansion blood vessel, decompression, improves the effects of microcirculation, enhancing hematopoiesis function；Rhizoma Atractylodis Macrocephalae energy
Spleen is enough transported, Wen Xinlie bitter in taste has the benefits of turbid eliminating dampness, change, analgesic；Poria cocos being capable of clearing damp and promoting diuresis, invigorating the spleen calming heart.Radix Angelicae Sinensis and jujube
It being capable of rich in nutrition.
By increasing the raw materials such as Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Angelicae Sinensis and jujube in the application, this can be further enhanced
Apply the Chinese medicine composition provided to the adjustment effect of beneficial bacteria of intestinal tract.
Research data shows, the effect of Chinese herbal medicines on Bifidobacteria be also it is various, can behave as facilitation, can also table
It is now inhibiting effect or even some drugs in various concentration, the influence to Bifidobacterium proliferation function is also completely different, or promotees
Into, or inhibit, or have no significant effect.Through inventor the study found that the said components in the application are matched using specific dosage
The growth that can promote beneficial bacteria of intestinal tract (such as Bifidobacterium, lactobacillus) is closed, the effect of prebiotics is served as.They are double by promoting
The growth of discrimination bacillus inhibits Escherichia coli Growth and treats diarrhea.
Preferably, raw material includes: 10-15 parts of dried orange peel according to parts by weight, and 5-10 parts of the coptis, 10-15 parts of evodia rutaecarpa, rhizoma zingiberis
5-10 parts, 10-15 parts of the tuber of pinellia, 5-10 parts of cimicifugae foetidae, burnt dark plum 10-15 parts, 10-15 parts of Schisandra chinensis, 10-15 parts of charred FRUCTUS CRATAEGI, garden burnet
It is 10-15 parts of charcoal, 10-20 parts of hairyvein agrimony, 10-15 parts of the bark of ash, 10-15 parts windproof, 15-25 parts of Radix Astragali, 12-18 parts of Radix Codonopsis, Rhizoma Atractylodis Macrocephalae
12-18 parts, 12-18 parts of Poria cocos, 10-15 parts of Radix Angelicae Sinensis, 10-15 parts of jujube.
It is highly preferred that raw material includes: 15 parts of dried orange peel according to parts by weight, and 6 parts of the coptis, 12 parts of evodia rutaecarpa, 6 parts of rhizoma zingiberis, half
10 parts of summer, 6 parts of cimicifugae foetidae, 10 parts of burnt dark plum, 10 parts of Schisandra chinensis, 10 parts of charred FRUCTUS CRATAEGI, 10 parts of charred RADIX SANGUISORBAE, 10 parts of hairyvein agrimony, the bark of ash 10
Part, 10 parts, 15 parts of Radix Astragali, 15 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 15 parts of Radix Angelicae Sinensis, 10 parts of jujube of radix saposhnikoviae.
In addition, present invention also provides a kind of preparation method of Chinese medicine composition for increasing gastrointestinal bacterial flora, preparation side
Method is simple, can be made into various medicaments by mixing after crushing above-mentioned raw materials.
Specifically, different medicaments is prepared according to the preparation method of different agents, medicament includes but is not limited to decoction, piece
Agent, pill, honeyed bolus etc..
In the application, preferably the medicament is honeyed bolus, and specific preparation method includes:
S1, pulverizing Chinese medicine raw material.
Above-mentioned raw materials are smashed it through into 80-100 mesh, grinding and sieving can guarantee that the Chinese medicine of powdery is finer and smoother,
It is subsequent when preparing honeyed bolus, it is easy to and honey bonds.Powder after sieving is placed in spare in disinfection basin.
S2, honey ingredient.
It is ratio artificial honey (such as 1000 grams of medicinal powder, the outfit 1200- of 1:1-1.5 with the weight ratio of medicinal powder and honey
1500 grams of honey；If more containing saccharic, colloid or starch in spice, it is equipped with 1: 1-1.2 ratio).
S3, tanning honey.
Honey is endured into boiling with high heat, is then continued to boil 30-60min with mild fire.The standard of tanning are as follows: by tanning bee
One bowl of cold water is placed by the container of honey, and pays attention to observing the color of honey.When finding honey yellowing foam, with a bamboo chopsticks in bee
It is stained with a drop in honey, then bamboo chopsticks are moved to above cold water bowl, honey is allowed to instill in water.If honey does not scatter in water and sinks
Bottom " drops into a bead ", indicate that honey has boiled completion at this time.
S4 and medicine.
Boiled honey is poured into the medicinal powder of disinfection basin splendid attire with spoon, while being stirred in medicinal powder with thick bamboo chopsticks,
In the while of falling honey tune medicinal powder, stop when being substantially not visible dry medicinal powder plus sweet.
S5, rubbing and and ball.
To avoid bolus from gluing hand or viscous utensil, rubbing with and when ball can with a small amount of sesame oil or peanut oil etc. point in the centre of the palm into
Row, is not only not easy adhesion, moreover it is possible to make the round and smooth light of pill in this way.
10 grams of calculating are weighed by every pill, a material medicine weighs 3000 grams altogether, to be then made into pill 300.Can by with good medicine
Group is divided into three and sticks together, often stick together be further divided into 5 it is small stick together, per the small rubbing that sticks together after, be cut to 20 sections, every section rubs a ball with the hands, it is remaining all it is quasi- this.
S6, packaging and storage.
Manufactured honeyed bolus, shape rounding is smooth, and surface compact moistens, without visible fiber or other heterochromatic points.To pill
Sweating after appearance is hardened, is wrapped with paraffin paper, preservative film, polybag or wax shell etc., and storage is in a cool and dry place.
By carrying out compatibility to various Chinese medicine materials in the application, dried orange peel and cimicifugae foetidae compatibility can be played into reducing phlegm and resolving masses
Effect, in addition, dried orange peel and cimicifugae foetidae all have certain bacteriostasis, wherein dried orange peel has good inhibiting effect to fungi, together
When can inhibit growth in conjunction with bacillus with cleaning intestine, cimicifugae foetidae, also have inhibiting effect to common causative dermatophyte.Simultaneously
The roughly the same coptis of channel tropism, evodia rutaecarpa, rhizoma zingiberis and the tuber of pinellia are compounded, this can be mutually coordinated, is further promoted
Antibacterial effect, and can heat-clearing and damp-drying drug, eliminating cold to stop pain and the effect of supporing yang antidiarrheal, beneficial bacteria of intestinal tract can be adjusted.Burnt dark plum
Negative tonifying yin can be held back with Schisandra chinensis.Charred FRUCTUS CRATAEGI being capable of promoting digestion and removing indigestion.Charred RADIX SANGUISORBAE, hairyvein agrimony can restrain, are anti-inflammatory, raising body is exempted from
Epidemic disease function.The bark of ash and radix saposhnikoviae can heat-clearing and damp-drying drug, clear wind-heat of liver channel.Chinese medicine can play defence and be controlled to the physical function of human body
Treatment effect, Chinese medicine can be according to the different different characteristics needed with drug of the state of an illness, selectively by two or more compatibility of drugs
It uses.Since Chinese medicine is to the prevention and treatment Mechanism Study of human body and indefinite, the tradition reason of " equilibrium between yin and yang " can only be rested on
By upper, it cannot get international endorsement.Inventor is through zoopery the study found that passing through compounding above-mentioned raw materials, energy in the present embodiment
It is enough effectively to inhibit harmful bacteria and protection beneficial bacteria.
The Chinese medicine composition obtained by above-mentioned preparation method can be widely used in treatment and the prevention and treatment chronic disease of alimentary canal
In the drug of disease, alimentary canal chronic disease includes but is not limited to atrophic, non-atrophic gastritis, gastric ulcer, gastric erosion, bursts
One of ulcer colitis, chronic enteritis, constipation, irritable bowel syndrome and depression are a variety of.
With reference to embodiments further to Chinese medicine composition of increase gastrointestinal bacterial flora of the invention and preparation method thereof
It is illustrated.
Embodiment 1
A kind of Chinese medicine composition for increasing gastrointestinal bacterial flora is present embodiments provided, raw material includes: dried orange peel 5-20g, yellow
Even 3-12g, evodia rutaecarpa 6-20g, rhizoma zingiberis 3-12g, tuber of pinellia 5-20g, cimicifugae foetidae 3-15g, burnt dark plum 5-20g, Schisandra chinensis 5-20g are burnt
Hawthorn 5-20g, charred RADIX SANGUISORBAE 5-20g, hairyvein agrimony 5-30g, the bark of ash 5-20g, windproof 5-20g.
Preparation method includes: that above-mentioned raw materials are smashed it through 80-100 mesh, is then pressed into sheet.
Embodiment 2
A kind of Chinese medicine composition for increasing gastrointestinal bacterial flora is present embodiments provided, raw material includes: dried orange peel 15g, the coptis
6g, evodia rutaecarpa 12g, rhizoma zingiberis 6g, tuber of pinellia 10g, cimicifugae foetidae 6g, burnt dark plum 10g, Schisandra chinensis 10g, charred FRUCTUS CRATAEGI 10g, charred RADIX SANGUISORBAE 10g are celestial
Crane grass 10g, the bark of ash 10g, windproof 10g, Radix Astragali 15g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 15g, Poria cocos 15g, Radix Angelicae Sinensis 15g, jujube 10g.
Preparation method includes:
S1, pulverizing Chinese medicine raw material.
Above-mentioned raw materials are smashed it through into 100 meshes, the powder after sieving are placed in spare in disinfection basin.
S2, honey ingredient.
It is the ratio artificial honey of 1:1.5 with the weight ratio of medicinal powder and honey.
S3, tanning honey.
Honey is endured into boiling with high heat, is then continued to boil xx-xxmin with mild fire.
S4 and medicine.
Boiled honey is poured into the medicinal powder of disinfection basin splendid attire with spoon, while being stirred in medicinal powder with thick bamboo chopsticks,
In the while of falling honey tune medicinal powder, stop when being substantially not visible dry medicinal powder plus sweet.
S5, rubbing and and ball.
To avoid bolus from gluing hand or viscous utensil, rubbing with and when ball can with a small amount of sesame oil or peanut oil etc. point in the centre of the palm into
Row, is not only not easy adhesion, moreover it is possible to make the round and smooth light of pill in this way.10 grams of calculating are weighed by every pill.
S6, packaging and storage.
Manufactured honeyed bolus, shape rounding is smooth, and surface compact moistens, without visible fiber or other heterochromatic points.To pill
Sweating after appearance is hardened, is wrapped with paraffin paper, preservative film, polybag or wax shell etc., and storage is in a cool and dry place.
Embodiment 3-6
The preparation method of the Chinese medicine composition for the increase gastrointestinal bacterial flora that embodiment 3-6 is provided is same as Example 2, difference
It is, the dosage of raw material is different.
The raw material of embodiment 3 includes: dried orange peel 8g, coptis 4g, evodia rutaecarpa 6g, rhizoma zingiberis 3g, tuber of pinellia 6g, cimicifugae foetidae 4g, burnt dark plum
6g, Schisandra chinensis 5g, charred FRUCTUS CRATAEGI 6g, charred RADIX SANGUISORBAE 6g, hairyvein agrimony 5g, the bark of ash 5g, windproof 5g, Radix Astragali 10g, Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 10g,
Poria cocos 11g, Radix Angelicae Sinensis 6g, jujube 6g.
The raw material of embodiment 4 includes: dried orange peel 15g, coptis 10g, evodia rutaecarpa 15g, rhizoma zingiberis 10g, tuber of pinellia 15g, cimicifugae foetidae 10g,
Burnt dark plum 15g, Schisandra chinensis 15g, charred FRUCTUS CRATAEGI 15g, charred RADIX SANGUISORBAE 14g, hairyvein agrimony 18g, the bark of ash 14g, windproof 15g, Radix Astragali 23g, party
Join 16g, Rhizoma Atractylodis Macrocephalae 18g, Poria cocos 16g, Radix Angelicae Sinensis 15g, jujube 14g.
The raw material of embodiment 5 includes: dried orange peel 10g, coptis 5g, evodia rutaecarpa 11g, rhizoma zingiberis 5g, tuber of pinellia 12g, cimicifugae foetidae 7g, burnt crow
Plum 12g, Schisandra chinensis 12g, charred FRUCTUS CRATAEGI 12g, charred RADIX SANGUISORBAE 12g, hairyvein agrimony 16g, the bark of ash 12g, windproof 12g, Radix Astragali 18g, Radix Codonopsis
16g, Rhizoma Atractylodis Macrocephalae 14g, Poria cocos 12g, Radix Angelicae Sinensis 11g, jujube 11g.
The raw material of embodiment 6 includes: dried orange peel 20g, coptis 12g, evodia rutaecarpa 20g, rhizoma zingiberis 12g, tuber of pinellia 18g, cimicifugae foetidae 12g,
Burnt dark plum 18g, Schisandra chinensis 18g, charred FRUCTUS CRATAEGI 18g, charred RADIX SANGUISORBAE 18g, hairyvein agrimony 28g, the bark of ash 18g, windproof 18g, Radix Astragali 28g, party
Join 18g, Rhizoma Atractylodis Macrocephalae 18g, Poria cocos 17g, Radix Angelicae Sinensis 16g, jujube 18g.
Embodiment 7-10
The raw material of the Chinese medicine composition for the increase gastrointestinal bacterial flora that embodiment 7-10 is provided is same as Example 2, and difference exists
In preparation process is different.
In embodiment 7, raw material is smashed it through into 80 meshes.
It is the ratio artificial honey of 1:1 with the weight ratio of medicinal powder and honey in embodiment 8.
It is the ratio artificial honey of 1:1.2 with the weight ratio of medicinal powder and honey in embodiment 9.
In embodiment 10, above-mentioned raw materials plus water are boiled.
One, experiment in vitro
1. experimental method
The preparation of 1.1 anaerobic environments: will be inoculated with the culture medium of bacterium, be placed in rapidly in anaerobism bag, be put into production gas bag,
After sealing under corresponding conditions stationary culture.
The activation of 1.2 freeze-drying lactobacillus: it in desinfection chamber, first needs to carry out disinfection to ampoule outer surface using preceding, uses 75%
After the wiping of alcohol absorbent cotton, its top is heated with flame, then drips a small amount of sterile water to making to the ampulla top of heating
Rupture, the ampoule top ruptured is struck down with tweezers.Then about 0.3 milliliter of corresponding Liquid Culture is drawn with aseptic straw
Base is instilled in ampoule, is gently vibrated, and making that thallus is lyophilized and sufficiently dissolves is in suspension.Whole bacteria suspensions are drawn by several times, are transplanted in phase
In the fluid nutrient medium test tube answered, the static gas wave refrigerator under corresponding conditions.Wherein, Bifidobacterium, Lactobacillus rhamnosus activation condition
Are as follows: 37 DEG C of Anaerobic culturels to muddiness, it is continuous to activate 2-3 generation, to improve bacterial strain vigor.
1.3 select Bifidobacterium, Lactobacillus rhamnosus for this experimental strain.By activated Bifidobacterium, rhamnose
Lactobacillus is configured to the bacterium solution of 0.5 Maxwell concentration, and (bacterial concentration is about 1.5*108CFU/ml), it is inoculated in Bifidobacterium BS respectively
Culture medium (be free of agar) and MRS culture medium and 6.25%, in the Chinese-medicinal culture medium of 12.5%, 25%, 50% concentration, not connect
The Chinese-medicinal culture medium of the respective concentration of kind bacterium is blank group, 37 DEG C of Anaerobic culturel Bifidobacteriums 14h, 16h, 18h and sandlwood
After sugared lactobacillus 12h, 14h, 16h, 10 times are diluted, its absorbance OD is surveyed570Value, by light absorption value to each Chinese medicine group to probiotics
Growth in vitro effect is compared.
Testing result takes the bacterium colony of different grouping to be detected respectively, and testing result is as shown in table 1:
1. experimental data of table (Rat with Ulcerative Colitis, intestinal flora variation)
OD1It is 0% bacterium solution OD value for control group (not Chinese medicine intervention blank control group)；The OD1Group is in BS culture medium
It is not inoculated with Chinese-medicinal culture medium concentration data with MRS culture medium；OD2It is 6.5% bacterium solution OD value for middle concentration；OD3For middle concentration
For 12.5% bacterium solution OD value；OD4It is 25% bacterium solution OD value for middle concentration；OD5It is 50% bacterium solution OD value for middle concentration.Through seeing
It examines, it is best to the increase effect of intestinal beneficial bacterium for 50% bacterium solution with middle concentration in each Chinese medicine group.
Wherein, one group of Chinese medicine, two groups of Chinese medicine and three groups of Chinese medicine are the increase gastrointestinal bacterial flora prepared using embodiment 2
Different concentration Chinese-medicinal culture mediums is configured to after the concentrated dilution of Chinese medicine composition, it can be found that the Chinese-medicinal culture medium of various concentration
It is different to the increase effect of Bifidobacterium with Lactobacillus rhamnosus.
Two, clinical research
126 are randomly divided into treatment group 63 through gastroscope and definitive pathological diagnosis, the CAG patient that Chinese medical discrimination is deficiency of Yin network stasis syndrome
With control group 63, treatment group is treated using the concentrating agents that the pharmaceutical composition in embodiment 2 is prepared, 3 times/
It；Control group (is produced) with oral WEIFUCHUN PIAN by Huqingyutang Pharmaceutical Co., Ltd., Hangzhou City, and 4 pieces/times, 3 times/day.12 Mondays
A course for the treatment of, after the course for the treatment of, treatment group's total effective rate is 89.86%, and control group total effective rate is 69.12%.Treatment group is at a specified future date
Good effect and adverse reaction is not found.By carrying out compatibility to various Chinese medicine materials in the application, by dried orange peel and cimicifugae foetidae compatibility energy
Enough play the role of reducing phlegm and resolving masses, in addition, dried orange peel and cimicifugae foetidae all have certain bacteriostasis, wherein dried orange peel has fungi
Good inhibiting effect, while can inhibit the growth in conjunction with bacillus with cleaning intestine, cimicifugae foetidae, to common causative dermatophyte
Also there is inhibiting effect.The roughly the same coptis of channel tropism, evodia rutaecarpa, rhizoma zingiberis and the tuber of pinellia are compounded simultaneously, this being capable of phase
Mutually coordinate, further promote antibacterial effect, and can heat-clearing and damp-drying drug, eliminating cold to stop pain and the effect of supporing yang antidiarrheal, can adjust
Beneficial bacteria of intestinal tract.Burnt dark plum and Schisandra chinensis can hold back negative tonifying yin.Charred FRUCTUS CRATAEGI being capable of promoting digestion and removing indigestion.Charred RADIX SANGUISORBAE, hairyvein agrimony can receive
It holds back, is anti-inflammatory, improving body's immunity.The bark of ash and radix saposhnikoviae can heat-clearing and damp-drying drug, clear wind-heat of liver channel.Pass through compounding in the present embodiment
Above-mentioned raw materials can effectively inhibit harmful bacteria and protection beneficial bacteria.Preparation method is simple, can be pressed using above-mentioned raw materials
Different dosage forms, including but not limited to tablet, pill, decoction etc. are prepared according to the preparation method of various medicaments, can be effectively used for
Treatment and prevention and treatment alimentary canal chronic disease.
These are only the preferred embodiment of the present invention, is not intended to restrict the invention, for those skilled in the art
For member, the invention may be variously modified and varied.All within the spirits and principles of the present invention, it is made it is any modification,
Equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for increasing gastrointestinal bacterial flora, which is characterized in that its raw material includes dried orange peel 5- according to parts by weight
20 parts, 3-12 parts of the coptis, 6-20 parts of evodia rutaecarpa, 3-12 parts of rhizoma zingiberis, 5-20 parts of the tuber of pinellia, 3-15 parts of cimicifugae foetidae, burnt dark plum 5-20 parts, five
It is 5-20 parts of taste, 5-20 parts of charred FRUCTUS CRATAEGI, 5-20 parts of charred RADIX SANGUISORBAE, 5-30 parts of hairyvein agrimony, 5-20 parts of the bark of ash, 5-20 parts windproof.
2. the Chinese medicine composition according to claim 1 for increasing gastrointestinal bacterial flora, which is characterized in that the raw material is by weight
Number meter further include: 10-30 parts of Radix Astragali, 10-20 parts of Radix Codonopsis, 10-20 parts of Rhizoma Atractylodis Macrocephalae, 10-20 parts of Poria cocos, 5-20 parts of Radix Angelicae Sinensis, jujube
5-20 parts.
3. the Chinese medicine composition according to claim 2 for increasing gastrointestinal bacterial flora, which is characterized in that the raw material is by weight
Number meter includes: 10-15 parts of dried orange peel, and 5-10 parts of the coptis, 10-15 parts of evodia rutaecarpa, 5-10 parts of rhizoma zingiberis, 10-15 parts of the tuber of pinellia, cimicifugae foetidae 5-
10 parts, burnt dark plum 10-15 parts, 10-15 parts of Schisandra chinensis, 10-15 parts of charred FRUCTUS CRATAEGI, 10-15 parts of charred RADIX SANGUISORBAE, 10-20 parts of hairyvein agrimony, the Qin
It is 10-15 parts of skin, 10-15 parts windproof, 15-25 parts of Radix Astragali, 12-18 parts of Radix Codonopsis, 12-18 parts of Rhizoma Atractylodis Macrocephalae, 12-18 parts of Poria cocos, Radix Angelicae Sinensis 10-
15 parts, 10-15 parts of jujube.
4. a kind of preparation method of the Chinese medicine composition as described in claim 1 for increasing gastrointestinal bacterial flora, which is characterized in that its
Including being mixed and made into medicament after crushing the raw material.
5. the preparation method of the Chinese medicine composition according to claim 4 for increasing gastrointestinal bacterial flora, which is characterized in that by powder
Raw material after broken crosses 80-100 mesh.
6. the preparation method of the Chinese medicine composition according to claim 4 for increasing gastrointestinal bacterial flora, which is characterized in that described
Medicament is honeyed bolus.
7. the preparation method of the Chinese medicine composition according to claim 6 for increasing gastrointestinal bacterial flora, which is characterized in that described
The preparation method of honeyed bolus includes: that the honey after tempering is added into the smashed raw material, stirs evenly to obtain mixture, will
After the mixture rubbing and ball.
8. the preparation method of the Chinese medicine composition according to claim 7 for increasing gastrointestinal bacterial flora, which is characterized in that described
The ratio between the weight of honey and the total weight of the raw material are 1-1.5:1.
9. the preparation method of the Chinese medicine composition according to claim 7 for increasing gastrointestinal bacterial flora, which is characterized in that temper
The honey includes: that the honey is endured boiling with high heat, is then continued to boil 30-60min with mild fire.
10. a kind of Chinese medicine composition as described in any one of claims 1-3 for increasing gastrointestinal bacterial flora and such as claim
The increase gastrointestinal bacterial flora that the preparation method of the described in any item Chinese medicine compositions for increasing gastrointestinal bacterial flora of 4-9 prepares
Application of the Chinese medicine composition in the drug treated and prevent and treat alimentary canal chronic disease, which is characterized in that the alimentary canal is chronic
Disease includes that atrophic, non-atrophic gastritis, gastric ulcer, gastric erosion, ulcerative colitis, chronic enteritis, constipation, intestines are easy
One of bowel syndrome and depression are a variety of.
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| CN110051776A (en) * | 2019-05-06 | 2019-07-26 | 宁夏医科大学 | A kind of Chinese medicine composition of adjustable gastric intestinal flora, traditional Chinese medicine pill and the preparation method and application thereof |
| CN111249396A (en) * | 2020-03-16 | 2020-06-09 | 宁夏医科大学 | Traditional Chinese medicine for treating chronic gastritis and preparation method of micronized particles thereof |
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| CN110051776A (en) * | 2019-05-06 | 2019-07-26 | 宁夏医科大学 | A kind of Chinese medicine composition of adjustable gastric intestinal flora, traditional Chinese medicine pill and the preparation method and application thereof |
| CN111249396A (en) * | 2020-03-16 | 2020-06-09 | 宁夏医科大学 | Traditional Chinese medicine for treating chronic gastritis and preparation method of micronized particles thereof |
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