CN109998097A - It is a kind of for improving the health care product and preparation method of Woman climacteric symptom - Google Patents
It is a kind of for improving the health care product and preparation method of Woman climacteric symptom Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of for improving the health care product of Woman climacteric symptom, it include major ingredient and the compound composition of auxiliary material, wherein major ingredient includes ginsenoside or extract of Radix Ginseng stem and leaf, isoflavones, pueraria isoflavone or pueraria isoflavone extract, caragana extract；Auxiliary material includes vitamin B, vitamin D, propolis.The invention has the following beneficial effects: improving immune, improvement women's climacteric syndrome, the generation of pre- anti-osteoporosis and gynecological cancer.Invention formulation capsule sanitary edible, conveniently, safely.The invention also discloses a kind of for improving the preparation method of the health care product of Woman climacteric symptom.
Description
Technical field
The invention belongs to the field of food with specific healthcare function, and in particular to one kind is for improving Woman climacteric disease
The health care product and preparation method of shape.
Background technique
Climacteric syndrome means each organ due to caused by climacteric psychiatric, neuroendocrine and metabolic alterations
The symptom of system and comprehensive syndrome.Climacteric syndrome also has title " menopausal syndrome " in traditional Chinese medicine.Mostly because of women general
Through disconnected year, congenital kidney qi degradation, conception vessel is empty, and taichong channel declines, and menses will exhaust, and body yin-yang is caused to lose the dilute or deficiency of the kidney yin, sun
It loses hiding；Or decline of kidney-YANG, passages through which vital energy circulates, which loses, supports in temperature and a series of disease of viscera function disorders occurs.Symptoms include irregular menstruation, face
Flushed face in the afternoon, irritable or melancholy, dizziness and tinnitus, dry is just dry etc., is syndrome of deficiency of kidney yin；If symptoms include irregular menstruation, colourless mind is tired,
Aversion to cold and cold limbs, ache of the spinal column, private parts are fallen again, anorexia and loose stool, are deficiency of kidney-YANG syndrome；It is simultaneous to see that the red flushing of cheekbone, dysphoria are few if irregular menstruation
It sleeps, hectic fever night sweat, soreness and weakness of waist and knees, dizzy palpitaition, blood pressure raising etc., are kidney deficiency in both YIN and YANG；Furthermore still intentionally two void person of kidney etc..Most
Typical symptom is hectic fever flush, mostly occurs in 45-55 years old, and most of women may occur in which the symptom that weight does not wait, Major Clinical
Be presented with hectic fever, perspiration, menstrual cycle extend, are irregular, being measured less, sleeping time perversion, age of meuopause too early, daytime drowsiness
Nocturnal insomnia, mental state are bad, menopause is flushing, violence impulsive action, feelings will internal injury, mouth are peppery, oestrogen deficiencies and autumn are manic
Disease, someone start to occur in menopause transition symptom, continue to post menopausal 2-3, and there are also some to continue to post menopausal 5-8
Year symptom is just mitigated or is disappeared.
Treating the method for climacteric syndrome now is mainly drug therapy, and there are side effects for drug therapy.Mankind's longevity
The aging of life is the important trend of modern society.Therefore the health care of climacteric and postmenopausal women and disease are anti-
It controls, is then ob-gyn or even the vital task that entire society is faced.
Summary of the invention
It is a kind of for effective the purpose of the invention is to be provided for the health problem of climacteric women at this stage
Improve the health care product of Woman climacteric symptom, while the present invention also provides the preparation methods of the health care product.
What the purpose of the present invention was achieved through the following technical solutions:
A kind of includes major ingredient and the compound composition of auxiliary material for improving the health care product of Woman climacteric symptom, and wherein major ingredient includes
Have: ginsenoside or extract of Radix Ginseng stem and leaf, isoflavones, pueraria isoflavone or pueraria isoflavone extract, golden pheasant
Youngster's extract；Auxiliary material includes vitamin B, vitamin D, propolis.
Further, the major ingredient and auxiliary material are by weight composition: major ingredient 60-74%, vitamin B 3-6%, propolis 20-
30%, vitamin D 3-5%；The major ingredient is constituted by following weight ratio: ginsenoside or extract of Radix Ginseng stem and leaf 10-
25%, isoflavones 15-30%, pueraria isoflavone or pueraria isoflavone extract 30-45%, caragana extract 30-40%.
Further, the auxiliary material further includes having amino acid, and major ingredient and auxiliary material are by weight composition: major ingredient 50-59%,
Vitamin B 3-6%, amino acid 20-25%, propolis 15-20%, vitamin D 3-5%；The major ingredient is constituted by following weight ratio:
Ginsenoside 20-25%, isoflavones 25-30%, pueraria isoflavone 20-25%, caragana extract 30-35%.
Further, the auxiliary material further includes having amino acid, and major ingredient and auxiliary material are by weight composition: major ingredient 50-59%,
Vitamin B 3-6%, amino acid 20-25%, propolis 15-20%, vitamin D 3-5%；The major ingredient is constituted by following weight ratio:
Extract of Radix Ginseng stem and leaf 20-25%, isoflavones 25-30%, pueraria isoflavone extract 20-25%, caragana extract 30-
35%。
Further, the major ingredient and auxiliary material are by weight composition: major ingredient 50%, vitamin B compound 5%, amino acid
20%, propolis 20%, vitamin D 5%；The major ingredient is constituted by following weight ratio: ginsenoside 25%, isoflavones
25%, pueraria isoflavone 20%, caragana extract 30%.
Further, the major ingredient and auxiliary material are by weight composition: major ingredient 59%, vitamin B compound 3%, amino acid
20%, propolis 15%, vitamin D 3%；The major ingredient is constituted by following weight ratio: the different Huang of extract of Radix Ginseng stem and leaf 20%, soybean
Ketone 25%, pueraria lobata total isoflavone extract 20%, caragana isoflavone extract 35%.
Further, the extract of Radix Ginseng stem and leaf is prepared as follows: after gen-seng haulms drying, by powder
Broken, the ethyl alcohol measured using 15 times is extracted three times, extraction time is respectively 3h, 3h and 2h as solvent with 95% ethyl alcohol；Extracting solution filtering,
Combined extract stands 24 hours, takes supernatant, when adding sodium hydroxide adjusts pH value to 10~12, through macroporous resin adsorption, uses
Decontamination is washed, alcohol-water elutes general ginsenoside, concentrate eluant, decoloration, recycling ethyl alcohol to no alcohol；Continue concentration and evaporation
Water is to specific gravity d=1.15；Spray drying, pulverizes and sieves to obtain the final product.
A kind of preparation method for the health care product being used to improve Woman climacteric symptom as described above, including following step are poly-:
(1) ginsenoside or extract of Radix Ginseng stem and leaf, isoflavones, the pueraria lobata for weighing formula ratio that is dry, crushing are different
Flavones or pueraria isoflavone extract, caragana extract stir evenly；Again with the compound vitamins of formula ratio, vitamin D,
Amino acid, propolis are uniformly mixed；
(2) uniformly mixed above-mentioned raw materials are subjected to capsule subpackage.
In the present invention, isoflavones, pueraria isoflavone raw material is directly bought according to national standards, or uses pueraria isoflavone
Total extract.Subsidize component: vitamin B compound, vitamin D, amino acid, propolis are directly bought according to standards of pharmacopoeia.
The extraction of pueraria isoflavone extract: pueraria lobata is measured with 8 times, and 75% alcohol reflux extracts three times, recycles ethyl alcohol, concentration
The total extract of pueraria isoflavone must be contained.
The extraction of caragana extract: caragana is extracted using ethyl alcohol as Extraction solvent using the multiple absorption method of continuous backflow
Total isoflavone.Dry caragana is crushed, 40 meshes is crossed, is measured with 6 times, 75% alcohol reflux extracts recycling ethyl alcohol three times and obtains golden pheasant
Youngster's isoflavones total extract.
The present invention is to be combined with ginsenoside and a variety of isoflavones, improves the various symptoms that Woman climacteric occurs,
Pre- preventing bone rarefaction, the generation of gynaecological imflammation.
The effect of ginseng has replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforces the spleen to benefit the lung, and promotes the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence.Ginseng is applied to
Tcm clinical practice has more than 2000 years history, since it is with extensive pharmacological action and medical application and by lot of domestic and foreign scholar
Attention.The principle active component of ginseng is ginsenoside, and in recent years, chemistry, pharmacology and clinical research prove, gen-seng haulms
The pharmacological action of contained ginsenoside and ginseng saponin(e are essentially identical, and total saponin content is apparently higher than ginseng, about 6~
12%.Ginsenoside has a variety of pharmacological activity, as resisting cardiovascular systemic disease, anti-senile dementia, anti-diabetic, enhancing are exempted from
The pharmacological actions such as epidemic disease power, antifatigue, antitumor, antibacterial, antiviral, inhibition Apoptosis.Ginsenoside also have adjust hormone,
Enhancing is immunized, prevents the effect of osteoporosis, anti-cancer and cancer-preventing.
Isoflavones is flavone compound, is a kind of secondary metabolite formed in soybean growth, is a kind of life
Active substances.There is isoflavones improvement menopause symptom, osteoporosis, blood lipid to increase, prevent breast cancer, uterine cancer etc.
The generation of gynecological cancer.It is considered related with its product phytoestrogen for generating this result.Isoflavones shows female
Hormone-like effect shows estrogenic antagonist to the young woman more than estrogen, many to climacteric women related to hormone decline
Disease such as climacteric syndrome, blood lipid increases, and artery sclerosis has certain effect.Isoflavones is to the low person's table of estrogen level
It is now weak estrogen action, in conjunction with the estrogen receptor in osteoblast, reinforces the activity at same cell, promote bone matrix
Generate, secretion and bone mineralization process, can pre- anti-osteoporosis generation.Human body takes in the isoflavones of higher dosage and big
The bone density of lumbar vertebra can be improved in legumin.Isoflavones has anticancer, protective effect on cancer risk.To caused by the variation of women's estrogen
Gynecological cancer such as breast cancer, cervical carcinoma etc. has certain preventive and therapeutic effect.Isoflavones also has anti-oxidant, anti-aging, pre-
The effects of anti-cardiovascular disease.
Kudzu vine root is isoflavone compound, and female such as Puerarin, daidzin, daidzein and human secretory swashs
Plain structure is similar, and there is estrogenic activity, which to be also referred to as phytoestrogen, can improve menopause symptom.Puerarin and pueraria lobata are total
Isoflavones has the characteristic of estrogen receptor partial agonist, can play estrogen-like action in conjunction with estrogen receptor.
Ovarian function can be improved simultaneously.There is anti-curing osteoporosis as isoflavones, pueraria isoflavone can promote in vivo
Calcium uptake promotes bone growth, inhibits estrogen lowly caused calcium loss, maintains bone mineral density level, promote the shape of osteocyte
At increase bone weight and bone calcium weight, to prevent and treat the generation of Postmenopausal Osteoporosis.
Caragana effective component is also isoflavone compound, has the above osajin like bioactivity.
Vitamin B compound, vitamin D and amino acid, which have, to be promoted to be metabolized and prevent osteoporosis effect in vivo, to treatment
Women's climacteric syndrome has good health-care effect.Propolis main component is that Flavonoid substances are comprehensive to treatment Woman climacteric
Disease and cardiovascular disease have a certain effect.
The present invention combination more than effective component can enhance it is immune, improve climacteric syndrome, prevent osteoporosis and
The generation of gynecological cancer prevents the generation of cardiovascular disease, makees to middle aged and aged women and climacteric women with good health care
With.Improve body yin-yang from Traditional Chinese health theory and lose the dilute or deficiency of the kidney yin, sun loses hiding；Or decline of kidney-YANG, passages through which vital energy circulates loses supports in temperature
And there is a series of disease of viscera function disorders.
Health care product of the present invention is a kind of improvement women's climacteric syndrome, prevents Woman climacteric osteoporosis and gynaecology
The health-caring capsule of cancer, the capsule can be used for improving the various symptoms of climacteric women appearance such as flush, perspiration, body it is numb,
The symptoms such as sleep disturbance, neuroticism, melancholia, vertigo, fatigue, muscle arthralgia, while can increase bone density, it is effectively slow
The problem of solving climacteric women osteoporosis, the generation of gynecological cancer can be prevented by adjusting female sex hormone.
The advantage of the invention is that in this capsule extract of Radix Ginseng stem and leaf fictitious hosts valuableness ginseng, cooperate the different Huang of soybean
Ketone, pueraria isoflavone, caragana Component of isoflavone more play raising and are immunized, and improve women's climacteric syndrome, prevent sclerotin
The effect of the generation of osteoporosis and gynecological cancer.It is suitable for the health care of Woman climacteric and middle aged and aged women crowd and supplies to control
It treats, and capsule is convenient, hygienic, safe.
Specific embodiment
Embodiment 1
Major ingredient formula: ginseng stem and leave general saponin 25g, isoflavones 25g, pueraria isoflavone 20g, caragana extract 30g；
The side of recruiting: above-mentioned major ingredient 50g, multi-vitamins 5g, amino acid 20g, propolis 20g, vitamin D 5g.The above raw material is 50
It is 12 hours dry in DEG C environment, particle is made, crosses 120 meshes, it is encapsulated.
Embodiment 2
Major ingredient formula: extract of Radix Ginseng stem and leaf 20g, isoflavones 25g, pueraria isoflavone extract 20g, caragana extract
35g；Wherein the extract of Radix Ginseng stem and leaf is prepared as follows: after gen-seng haulms drying, by crushing, being measured with 15 times
Ethyl alcohol be solvent, with 95% ethyl alcohol extract three times, extraction time is respectively 3h, 3h and 2h；Extracting solution filtering, combined extract
24 hours are stood, takes supernatant, when adding sodium hydroxide adjusts pH value to 10~12, through macroporous resin adsorption, decontamination is washed with water,
Alcohol-water elutes general ginsenoside, concentrate eluant, decoloration, recycling ethyl alcohol to no alcohol；Continue concentration and evaporation water to specific gravity d=
1.15；Spray drying, pulverizes and sieves to obtain the final product.The extraction of pueraria isoflavone extract: pueraria lobata is measured with 8 times, and 75% alcohol reflux extracts
Three times, ethyl alcohol is recycled, the total extract containing pueraria isoflavone is concentrated to give.The extraction of caragana extract: by dry caragana powder
It is broken, 40 meshes are crossed, are measured with 6 times, 75% alcohol reflux extracts recycling ethyl alcohol three times and obtains caragana isoflavones total extract.
The side of recruiting: above-mentioned major ingredient 59g, multi-vitamins 3g, amino acid 20g, propolis 15g, vitamin D 3g.The above raw material
It is 12 hours dry in 50 DEG C of environment, particle is made, crosses 120 meshes, it is encapsulated.
Embodiment 3
Major ingredient formula: ginsenoside 25g, isoflavones 15g, pueraria isoflavone 30g, caragana extract 30g；
The side of recruiting: above-mentioned major ingredient 60g, multi-vitamins 5g, propolis 30g, vitamin D 5g.It is dry in 50 DEG C of environment with feeding
12 hours, particle is made, crosses 120 meshes, it is encapsulated.
Embodiment 4
Major ingredient formula: extract of Radix Ginseng total saponins 15g, isoflavones 25g, kudzu root extract 30g, caragana extract
Object 30g；
The side of recruiting: above-mentioned major ingredient 74g, vitamin B 3g, vitamin D 3g, propolis 20g, above-mentioned that particle is made, dry, crushing fills
Capsule.
Preparation method of the present invention is simple, low in cost using the ginseng of extract of Radix Ginseng stem and leaf fictitious hosts valuableness, can grasp
The property made is strong.Nuisanceless to environment, safety and environmental protection improves the symptom of various climacteric syndromes, is easy to absorb, and does not find obvious
Toxic side effect.Extract of Radix Ginseng stem and leaf cooperation isoflavones, pueraria isoflavone, caragana Component of isoflavone are more played and are mentioned
Height is immune, the effect of the generation of pre- anti-osteoporosis and gynecological cancer.It can produce extensively and constantly replace current material.
Clinical test example: by taking 300 with climacteric syndrome women as an example, patient age all has between 45-55 years old
There is hectic fever, perspiration, menstrual cycle to prolong, irregularly, measured less, the symptoms such as osteoporosis, gynaecological imflammation, the course of disease 1 year by 8 years not
Deng.Above-mentioned patient is divided into four groups, every group of average 75 people.
Four groups of patients take the obtained health product capsule for improving climacteric syndrome of examples detailed above 1,2,3,4 respectively,
3 times a day, each 1-3 piece, continuously takes a month as a treatment course, takes the 3-5 course for the treatment of, record and count patient the state of an illness and
Curative effect situation.It the results are shown in Table 1.
The standard of health-care effect judgement:
Effective: the symptoms such as patient's hectic fever, perspiration, paramenia, gynaecological imflammation completely disappear.
Effective: patient's hectic fever, perspiration, irritability melancholy, osteoporosis, the symptoms such as gynaecological imflammation are improved.
Invalid: each symptom does not improve or aggravates.
1 efficacy result of table
Table 1 statistics indicate that, capsule of the invention is significant in efficacy for climacteric women, and has no toxic side effect.
Above example is served only for being specifically described the content of present invention, rather than limits, and those skilled in the art can be to reality
Example carries out data point reuse or equivalent replacement, all it is believed that within claims of the present invention protection scope.
Claims (8)
- It include major ingredient and the compound composition of auxiliary material 1. a kind of for improving the health care product of Woman climacteric symptom, wherein major ingredient packet It has included: ginsenoside or extract of Radix Ginseng stem and leaf, isoflavones, pueraria isoflavone or pueraria isoflavone extract, brocade Chicken extract；Auxiliary material includes vitamin B, vitamin D, propolis.
- 2. according to claim 1 a kind of for improving the health care product of Woman climacteric symptom, it is characterised in that described Major ingredient and auxiliary material are by weight composition: major ingredient 60-74%, vitamin B 3-6%, propolis 20-30%, vitamin D 3-5%；The major ingredient is constituted by following weight ratio: ginsenoside or extract of Radix Ginseng stem and leaf 10-25%, isoflavones 15-30%, pueraria isoflavone or pueraria isoflavone extract 30-45%, caragana extract 30-40%.
- 3. according to claim 1 a kind of for improving the health care product of Woman climacteric symptom, it is characterised in that described Auxiliary material further includes having amino acid, and major ingredient and auxiliary material are by weight composition: major ingredient 50-59%, vitamin B 3-6%, amino acid 20- 25%, propolis 15-20%, vitamin D 3-5%；The major ingredient is constituted by following weight ratio: ginsenoside 20-25%, isoflavones 25-30%, pueraria isoflavone 20-25%, caragana extract 30-35%.
- 4. according to claim 1 a kind of for improving the health care product of Woman climacteric symptom, it is characterised in that described Auxiliary material further includes having amino acid, and major ingredient and auxiliary material are by weight composition: major ingredient 50-59%, vitamin B 3-6%, amino acid 20- 25%, propolis 15-20%, vitamin D 3-5%；The major ingredient is constituted by following weight ratio: extract of Radix Ginseng stem and leaf 20-25%, isoflavones 25-30%, the different Huang of pueraria lobata Ketone extract 20-25%, caragana extract 30-35%.
- 5. according to claim 3 a kind of for improving the health care product of Woman climacteric symptom, it is characterised in that described Major ingredient and auxiliary material are by weight composition: major ingredient 50%, vitamin B compound 5%, amino acid 20%, propolis 20%, vitamin D 5%；The major ingredient is constituted by following weight ratio: ginsenoside 25%, isoflavones 25%, pueraria isoflavone 20%, brocade Chicken extract 30%.
- 6. according to claim 4 a kind of for improving the health care product of Woman climacteric symptom, it is characterised in that described Major ingredient and auxiliary material are by weight composition: major ingredient 59%, vitamin B compound 3%, amino acid 20%, propolis 15%, vitamin D 3%；The major ingredient is constituted by following weight ratio: extract of Radix Ginseng stem and leaf 20%, isoflavones 25%, pueraria lobata total isoflavone mention Take object 20%, caragana isoflavone extract 35%.
- 7. according to claim 1 a kind of for improving the health care product of Woman climacteric symptom, it is characterised in that described Extract of Radix Ginseng stem and leaf is prepared as follows: after gen-seng haulms drying, by crushing, and using the ethyl alcohol of 15 times of amounts as solvent, It is extracted three times with 95% ethyl alcohol, extraction time is respectively 3h, 3h and 2h；Extracting solution filtering, combined extract stand 24 hours, take When adding sodium hydroxide adjusts pH value to 10~12, through macroporous resin adsorption, decontamination is washed with water, alcohol-water elutes people in supernatant Join total saposins, concentrate eluant, decoloration, recycling ethyl alcohol to no alcohol；Continue concentration and evaporation water to specific gravity d=1.15；Spray drying, It pulverizes and sieves to obtain the final product.
- 8. a kind of preparation method of the health care product for improving Woman climacteric symptom of such as claim 3 or 4, including following step It is poly-:(1) ginsenoside or extract of Radix Ginseng stem and leaf, isoflavones, the pueraria lobata for weighing formula ratio that is dry, crushing are different Flavones or pueraria isoflavone extract, caragana extract stir evenly；Again with the compound vitamins of formula ratio, vitamin D, Amino acid, propolis are uniformly mixed；(2) uniformly mixed above-mentioned raw materials are subjected to capsule subpackage.
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| EP4331384A1 (en) | 2022-08-30 | 2024-03-06 | Takasago International Corporation | Soy-based food, preparation process and use |
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Application publication date: 20190712 |