CN109985182A - A kind of Bi Collettii radix angelicae sinensis Chinese medicinal granule electuary and preparation method thereof - Google Patents

A kind of Bi Collettii radix angelicae sinensis Chinese medicinal granule electuary and preparation method thereof Download PDF

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CN109985182A
CN109985182A CN201711471387.9A CN201711471387A CN109985182A CN 109985182 A CN109985182 A CN 109985182A CN 201711471387 A CN201711471387 A CN 201711471387A CN 109985182 A CN109985182 A CN 109985182A
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chinese medicinal
collettii
angelicae sinensis
radix angelicae
electuary
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李晓静
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732—Chaenomeles, e.g. flowering quince
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/8994—Coix (Job's tears)
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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Abstract

The invention discloses a kind of traditional Chinese medicinal components of Bi Collettii radix angelicae sinensis Chinese medicinal granule electuary and preparation method thereof, using Bi Collettii and radix angelicae sinensis, it is aided with the 10 taste Chinese medicine such as cortex moutan, the root of fangji, semen coicis, radix cyathulae, licorice, honeysuckle, Fructus Forsythiae, pawpaw, through cleaning, extraction, be concentrated and dried, softwood processed, granulation, drying, whole grain, sterilization packaging the step of prepare particle electuary, facilitate patient to take, realizes the purpose consistent with the material base of traditional decoction of medicinal ingredients and clinical efficacy；It is the preferred particle electuary for treating fish maw carbuncle, has the function of significant blood circulation, stasis-dispelling and pain-killing, inducing diuresis for removing edema, invigorating spleen to remove dampness, relaxing muscles and tendons eliminating impediment, clearing away heat and eliminating pus；Duration of medication avoids eating raw food, avoids weight labor；Main treatment fish maw carbuncle；And it is significant in efficacy, it has no adverse reaction, it is without side-effects.

Description

A kind of Bi Collettii radix angelicae sinensis Chinese medicinal granule electuary and preparation method thereof
Technical field
The present invention relates to the technical field of Chinese medicine, espespecially a kind of Bi Collettii radix angelicae sinensis Chinese medicinal granule electuary and preparation method thereof.
Background technique
Fish maw carbuncle refers to the acute festering type illness between the skin and flesh of calf position, also known as diseased dried meat hair.It is equivalent to modern doctor The acute festering type cellulitis at shank gastrocnemius position.From the beginning of diseased dried meat portion, distending pain is not relaxed, and cannot be puted forth effort, and influences to live Dynamic, then skin lifts red, obscure boundary, the swollen pain of height.Indigestion and loss of appetite with cold fever, the constitutional symptoms such as red are urinated in constipation.About 1 week There is fluctuation in left and right by it at purulence, local pain aggravation.Purulence goes out yellow thick after bursting, and constitutional symptom mitigates or disappears therewith.If sore color Purple dark unrestrained swollen, bursting, purulence is slow, and pus is thin, then open sore part difficulty is held back.This disease need to mutually identify with suppurative osteomyelitis.Suppurative osteomyelitis onset is more anxious, companion High fever shiver with cold, pain to the bone, are feared.Skin redness is swollen afterwards, and pain can lighten, and thin after thick at the beginning of fester of bursting, the open sore part is not easy to heal, shape At sinus, sequestrum this disease can be visited and mainly condensed by liver and spleen, bladder damp-heat bet with qi and blood, or because of internal lesion caused by overexertion tendon and vessel, wound Hemostasis infects caused by cult poison.Its clinical characters is local congestion and swelling pain, and the gesture that swells is easily poly-, and purulence goes out yellow thick, the easy healing of the open sore part, in advance It is general how suitable afterwards.Caused by the damp and hot fire toxin of the reason of this disease, so card has actual situation, and poison has weight, and position is divided into shallow deep.The card of excess fire, Though damp and hot fire toxin is contained, right healthy tendency still belongs to not empty, and qi and blood is sufficient, and beam arrests poison heresy, then the gesture that swells is easily poly-, and easy purulence is easily burst and easily held back, and disease is lighter Shallowly;The card of the fire of deficiency type, the malicious Sheng Erzheng deficiency of vital energy, the inflexible poison of beam is not evil for qi and blood, then the gesture difficulty that swells is poly-, and the routed difficulty of difficult purulence difficulty is held back, and disease is very graver.
Although Chinese medicine be obtained by human experimentation in thousands of years as a result, Chinese medicine control fish maw carbuncle can with treating both manifestation and root cause of disease, and And Small side effects；But Chinese medicine is comparatively laborious in use, needs to decoct processing, needs professional processing technique of Chinese herbs ability It uses, many inconvenience is brought to patient；Therefore, how convenient and efficient using Chinese medicine treatment fish maw carbuncle symptom, become vast The hot spot that hospitalized patients are paid close attention to always.
Summary of the invention
A kind of Bi Collettii radix angelicae sinensis Chinese medicinal granule electuary of the present invention and preparation method thereof, can solve the deficiency of above-mentioned technology, Using Bi Collettii and radix angelicae sinensis, it is aided with 10 taste such as cortex moutan, the root of fangji, semen coicis, radix cyathulae, licorice, honeysuckle, Fructus Forsythiae, pawpaw Chinese medicine, through cleaning, extraction, be concentrated and dried, softwood processed, granulation, drying, whole grain, sterilization packaging the step of prepare particle electuary, Facilitate patient to take, realizes the purpose consistent with the material base of traditional decoction of medicinal ingredients and clinical efficacy.
To achieve the goals above, the technical solution of the invention is as follows: a kind of Bi Collettii radix angelicae sinensis Chinese medicinal granule electuary and The traditional Chinese medicinal components: Bi Collettii 24%~26% of preparation method, radix angelicae sinensis 7%~9%, cortex moutan 7%~9%, the root of fangji 9%~11%, coix lacryma-jobi Benevolence 12%~14%, radix cyathulae 5%~7%, licorice 4%~6%, honeysuckle 7%~9%, Fructus Forsythiae 6%~8%, pawpaw 9%~11%.
Preparation step is as follows:
(1) clear up: traditional Chinese medicinal components are removed into impurity, cleaned standby seam；
(2) extract: traditional Chinese medicinal components are placed in interlayer pot for solvent extraction, temperature 70 C~80 DEG C plus 10 times of amount water extract 3h, take extraction Liquid storage；Again plus 10 times of amount water, temperature 70 C~80 DEG C extract 3h, merge decoction liquor twice, with 100 mesh screens；
(3) be concentrated and dried: filtrate is placed in vacuum concentration pot, sets vacuum degree 97kPa, 55 DEG C~70 DEG C of temperature, is condensed into concentration Liquid, concentrate are the 25% of traditional Chinese medicinal components, then concentrate are obtained extraction powder by being spray-dried；
(4) softwood processed: extraction powder 30% is added in kneader, adds cane sugar powder 10%, dextrin 10%, dried starch 50%, uses content 50% ethyl alcohol is modulated to softwood medicine and sticks together；
(5) pelletize: wet shape particle is produced using granulator；
(6) dry: wet shape particle being placed in 60 DEG C of pneumatic drier and dehydrated；
(7) whole grain: by the particle after drying after 1 10 mesh sieve, particle electuary is obtained；
(8) particle electuary sterilization packaging: is placed under ultraviolet light to every bag of 20g packaging after irradiating 3min.
The effect of traditional Chinese medicinal components of the present invention and effect:
Bi Collettii: there is dampness removing to go turbid, wind and relieving paralysis of dispelling, dampness removing removes turbid, wind expelling stagnation removing；It is drenched for cream, gonorrhoea, leukorrhea, rheumatism The effect of numbness pain, articular instability, the diseases such as lumbocrural pain；
Radix angelicae sinensis: there is promoting blood circulation；The effect for the treatment of that menostasis is obstructed and the diseases such as the illness of the stagnant swelling and pain of hemostasis；
Cortex moutan: there is clearing heat and cooling blood, activate blood circulation and disperse blood clots, reducing the asthenic fever etc.；For warm heat disease heat invading xuefen；Macular eruption；Hematemesis；After pyreticosis Phase hot Fu Yin distribution heat；Deficiency of Yin osteopyrexia and fever；Amenorrhea due to stagnation of blood；Dysmenorrhea；Carbuncle sore tumefacting virus；The pain of injury caused by falling and tumbling；The effect of beriberoid pyretic arthralgia；
The root of fangji: there is wind-damp dispelling, analgesic, Li Shui；Pain in rheumatoid joints；Damp and hot limbs pain；Oedema；Difficult urination；Tinea pedis is wet Swollen effect；
Semen coicis: have effects that the diseases such as inducing diuresis for removing edema, invigorating spleen to remove dampness, relaxing muscles and tendons eliminating impediment, clearing away heat and eliminating pus；
Radix cyathulae: there is blood circulation, stasis-dispelling and pain-killing；Control hemostasis real example；It ignites (blood) downlink；Inducing diuresis for treating strangurtia；Soreness of waist and knee joint；Under Limb impotence is soft；Amenorrhea due to stagnation of blood；Dysmenorrhea；Postpartum abdominal pain due to blood stasis；Abdominal mass；Placenta retension；Heat gonorrhea；Blood strangury；Traumatic injury；Carbuncle swells dislikes sore； The effect of abscess of throat.
Licorice: there is spleen QI invigorating, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription；It is tired for weakness of the spleen and the stomach It is idle out of strength, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviation drug toxicity, strong effect；
Honeysuckle: has effects that clearing heat and detoxicating, cooling blood and removing stasis；
Fructus Forsythiae: there is heat-clearing, removing toxic substances, dissipating bind, detumescence；Control warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, the function of urine leaching closes Effect；
The effect of pawpaw: having and help digestion, expelling parasite, heat-clearing, wind-dispelling;Cure mainly stomachache, indigestion, lung heat dry cough, alactation, The effect of eczema, parasitic disease, trick spasm pain symptom.
Particle electuary of the present invention is the particle of brown color；Gas is micro-, bitter, slightly sweet；Using particle electuary manufacturing process ratio It is relatively simple, it is storage and transportation, carrying, easy to use；Every bag plus 100 DEG C of hot water 200ml, are sufficiently stirred dissolution, can take, and every time one Bag, 3 times a day.
The present invention is to use Bi Collettii and radix angelicae sinensis for main ingredient, be aided with Qin's cortex moutan, the root of fangji, semen coicis, radix cyathulae, life it is sweet There is dampness removing turbid, wind and relieving paralysis of dispelling, dampness removing to be gone to go turbid effect for the 10 taste Chinese medicine such as grass, honeysuckle, Fructus Forsythiae, pawpaw, Bi Collettii；It is aided with male The root bark of tree peony has effects that clearing heat and cooling blood, activates blood circulation and disperses blood clots；Semen coicis has inducing diuresis for removing edema, invigorating spleen to remove dampness, relaxing muscles and tendons eliminating impediment, clearing away heat and eliminating pus The effect of, pharmacological property is reasonably combined, can complement each other, promote drug effect；It is the preferred particle electuary for treating fish maw carbuncle, has significant Blood circulation, stasis-dispelling and pain-killing, inducing diuresis for removing edema, invigorating spleen to remove dampness, relaxing muscles and tendons eliminating impediment, clearing away heat and eliminating pus function；Duration of medication avoid eating raw food, Avoid weight labor；Main treatment fish maw carbuncle；And it is significant in efficacy, it has no adverse reaction, it is without side-effects.
Embodiment 1
Traditional Chinese medicinal components: Bi Collettii 24%, radix angelicae sinensis 7%, cortex moutan 7%, the root of fangji 9%, semen coicis 14%, radix cyathulae 7%, licorice 6%, Honeysuckle 7%, Fructus Forsythiae 8%, pawpaw 11%；
(2) preparation step is as follows:
1. cleaning: traditional Chinese medicinal components are removed impurity, cleaned standby seam；
2. extraction: traditional Chinese medicinal components being placed in interlayer pot for solvent extraction, temperature 70 C~80 DEG C plus 10 times of amount water extract 3h, take extraction Liquid storage；Again plus 10 times of amount water, temperature 70 C~80 DEG C extract 3h, merge decoction liquor twice, with 100 mesh screens；
3. being concentrated and dried: filtrate is placed in vacuum concentration pot, sets vacuum degree 97kPa, 55 DEG C~70 DEG C of temperature, is condensed into concentration Liquid, concentrate are the 25% of traditional Chinese medicinal components, then concentrate are obtained extraction powder by being spray-dried；
4. softwood processed: extraction powder 30% is added in kneader, adds cane sugar powder 10%, dextrin 10%, dried starch 50%, uses content 50% ethyl alcohol is modulated to softwood medicine and sticks together；
5. granulation: producing wet shape particle using granulator；
6. drying: wet shape particle being placed in 60 DEG C of pneumatic drier and dehydrated；
7. whole grain: by the particle after drying after 1 10 mesh sieve, obtaining particle electuary；
8. sterilization packaging: particle electuary is placed under ultraviolet light to every bag of 20g packaging after irradiating 2~3min.
Embodiment 2
(1) traditional Chinese medicinal components: Bi Collettii 25%, radix angelicae sinensis 8%, cortex moutan 8%, the root of fangji 10%, semen coicis 13%, radix cyathulae 6%, licorice 5%, honeysuckle 8%, Fructus Forsythiae 7%, pawpaw 10%；
(2) preparation step is as follows:
1. cleaning: traditional Chinese medicinal components are removed impurity, cleaned standby seam；
2. extraction: traditional Chinese medicinal components being placed in interlayer pot for solvent extraction, temperature 70 C~80 DEG C plus 10 times of amount water extract 3h, take extraction Liquid storage；Again plus 10 times of amount water, temperature 70 C~80 DEG C extract 3h, merge decoction liquor twice, with 100 mesh screens；
3. being concentrated and dried: filtrate is placed in vacuum concentration pot, sets vacuum degree 97kPa, 55 DEG C~70 DEG C of temperature, is condensed into concentration Liquid, concentrate are the 25% of traditional Chinese medicinal components, then concentrate are obtained extraction powder by being spray-dried；
4. softwood processed: extraction powder 30% is added in kneader, adds cane sugar powder 10%, dextrin 10%, dried starch 50%, uses content 50% ethyl alcohol is modulated to softwood medicine and sticks together；
5. granulation: producing wet shape particle using granulator；
6. drying: wet shape particle being placed in 60 DEG C of pneumatic drier and dehydrated；
7. whole grain: by the particle after drying after 1 10 mesh sieve, obtaining particle electuary；
8. sterilization packaging: particle electuary is placed under ultraviolet light to every bag of 20g packaging after irradiating 3min.
Embodiment 3
Traditional Chinese medicinal components: Bi Collettii 26%, radix angelicae sinensis 9%, cortex moutan 9%, the root of fangji 11%, semen coicis 12%, radix cyathulae 5%, licorice 4%, Honeysuckle 9%, Fructus Forsythiae 6%, pawpaw 9%；
(2) preparation step is as follows:
1. cleaning: traditional Chinese medicinal components are removed impurity, cleaned standby seam；
2. extraction: traditional Chinese medicinal components being placed in interlayer pot for solvent extraction, temperature 70 C~80 DEG C plus 10 times of amount water extract 3h, take extraction Liquid storage；Again plus 10 times of amount water, temperature 70 C~80 DEG C extract 3h, merge decoction liquor twice, with 100 mesh screens；
3. being concentrated and dried: filtrate is placed in vacuum concentration pot, sets vacuum degree 97kPa, 55 DEG C~70 DEG C of temperature, is condensed into concentration Liquid, concentrate are the 25% of traditional Chinese medicinal components, then concentrate are obtained extraction powder by being spray-dried；
4. softwood processed: extraction powder 30% is added in kneader, adds cane sugar powder 10%, dextrin 10%, dried starch 50%, uses content 50% ethyl alcohol is modulated to softwood medicine and sticks together；
5. granulation: producing wet shape particle using granulator；
6. drying: wet shape particle being placed in 60 DEG C of pneumatic drier and dehydrated；
7. whole grain: by the particle after drying after 1 10 mesh sieve, obtaining particle electuary；
8. sterilization packaging: particle electuary is placed under ultraviolet light to every bag of 20g packaging after irradiating 3min.
Using result: not sent out using this product clinical treatment using apparent toxic side effect is had no in patient through 89 patients Existing adverse reaction；Cure rate is efficient up to 100% up to 92%.
The above, embodiment is only that preferred embodiments of the present invention will be described, not to of the invention Range is defined, and under the premise of not departing from the spirit of the technology of the present invention, this field engineers and technicians are to skill of the invention The various changes and improvements that art scheme is made, should fall within the scope of protection determined by the claims of the present invention.

Claims (1)

1. a kind of Bi Collettii radix angelicae sinensis Chinese medicinal granule electuary and preparation method thereof, it is characterized in that: traditional Chinese medicinal components , Bi Collettii 24%~26%, Radix angelicae sinensis 7%~9%, cortex moutan 7%~9%, the root of fangji 9%~11%, semen coicis 12%~14%, radix cyathulae 5%~7%, licorice 4%~ 6%, honeysuckle 7%~9%, Fructus Forsythiae 6%~8%, pawpaw 9%~11%.
CN201711471387.9A 2017-12-29 2017-12-29 A kind of Bi Collettii radix angelicae sinensis Chinese medicinal granule electuary and preparation method thereof Pending CN109985182A (en)

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