CN109967138A - Biological detection platform - Google Patents
Biological detection platform Download PDFInfo
- Publication number
- CN109967138A CN109967138A CN201811512802.5A CN201811512802A CN109967138A CN 109967138 A CN109967138 A CN 109967138A CN 201811512802 A CN201811512802 A CN 201811512802A CN 109967138 A CN109967138 A CN 109967138A
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- China
- Prior art keywords
- sample
- runner
- buffer
- test board
- biological detection
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Links
- 238000001514 detection method Methods 0.000 title claims abstract description 52
- 238000012360 testing method Methods 0.000 claims abstract description 76
- 239000000872 buffer Substances 0.000 claims abstract description 60
- 239000012530 fluid Substances 0.000 claims description 34
- 239000007788 liquid Substances 0.000 claims description 23
- 239000008280 blood Substances 0.000 claims description 18
- 230000003139 buffering effect Effects 0.000 claims description 17
- 239000002699 waste material Substances 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 abstract description 5
- 230000009385 viral infection Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 238000000926 separation method Methods 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 77
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000012472 biological sample Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000011010 flushing procedure Methods 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000001141 propulsive effect Effects 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 230000002411 adverse Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The present invention provides a kind of biological detection platforms, which includes cover assembly, have the entrance flowed into for sample and buffer；Flow channel component offers the runner for sample and buffer flowing；Test board is connected to and for detecting sample with runner；Bottom plate is detachably connected with cover assembly；Wherein, cover assembly, flow channel component, test board, bottom plate are cascading.Biological detection platform provided by the invention; structure is simple, production cost is low and convenient for disassembly and assembly, and therefore, cover assembly, bottom plate and test board after disassembly separation will not generate the case where polluting environment when discarded; in order to avoid causing bacterium and virus infection before incineration process, environment can be protected.
Description
Technical field
The invention belongs to biological monitor technical fields, are to be related to a kind of biological detection platform more specifically.
Background technique
In order to quickly screen illness, the diagnosis cause of disease, the reasons such as forensic identification, need using detecting instrument to blood, saliva,
The biological samples such as gastric juice are detected, and there is still a need for trained technicians for most quantitative testing in laboratory environments
It uses.Understand the physical condition of oneself in real time in order to facilitate patient, part detecting instrument has been reduced to make at home for patient
Simple detection box.
But current detection box internal structure is complicated, internal residual has the biological sample such as a large amount of blood, urine after use
This, is not easy to recycle, and may cause and cause bacterium and virus infection, and then pollutes environment.
Summary of the invention
The purpose of the present invention is to provide a kind of biological detection platforms, to solve inside detection box existing in the prior art
The technical issues of remaining biological sample, being not easy to recycle, and may cause bacterium and virus infection.
To achieve the above object, the technical solution adopted by the present invention is that: a kind of biological detection platform is provided, comprising:
Cover assembly has the entrance flowed into for sample and buffer；
Flow channel component offers the runner for sample and buffer flowing；
Test board is connected to and for detecting sample with the runner；
Bottom plate is detachably connected with the cover assembly；
Wherein, the cover assembly, the flow channel component, the test board, the bottom plate are cascading.
Further, the cover assembly includes upper cover plate and anti-blood stains plug, and the entrance is opened in the upper cover plate, institute
Anti- blood stains plug is stated in the entrance.
Further, the upper cover plate has buckle towards the bottom plate side, is offered on the bottom plate for the card
The card slot that buckle connects.
Further, the entry number of the upper cover plate is two, respectively sample entrance port and buffer inlet, the stream
Road component includes overflow plate, and buffer runner, the buffer inlet and the buffer runner are offered on the overflow plate
Connection.
Further, the buffer runner include the buffering sap cavity faced with the buffer inlet, with it is described slow
The fluid channel of fliud flushing chamber connection, the waste liquid chamber being connected to the fluid channel, the bottom wall of the fluid channel are offered for buffering liquid stream
Enter the reaction mouth of the test board.
Further, the upper cover plate also has the diversion division protruded into the reaction mouth towards the bottom plate side.
Further, the overflow plate has the circumferential rib for being located on the reaction mouth, institute towards the test board side
Circumferential rib is stated to abut against with the test board.
Further, the flow channel component further includes the filter plate for sample of dialysing, and offers confession on the filter plate
The sample runner of the sample circulation, the entrance of the sample runner are connected to the sample entrance port, and the sample runner goes out
Mouth is connected to the test board.
Further, the surface of the upper cover plate has antiskid particles.
Further, the side of the bottom plate has hand-held part.
The beneficial effect of biological detection platform provided by the invention is: compared with prior art, biological detection of the present invention
Platform includes the flow channel component flowed into for sample and buffer and for the test board of test sample, cover assembly and bottom plate
Flow channel component and test board are fixed in the biological detection platform, and cover assembly and bottom plate are detachably connected, it should using
After biological detection platform, cover assembly and bottom plate can be separated, the biological detection platform structure is simple, production cost is low and dismounts
Convenient, therefore, cover assembly, bottom plate and test board after disassembly separation will not generate the case where polluting environment when discarded, with
Exempt to cause bacterium and virus infection before incineration process, environment can be protected.
Detailed description of the invention
It to describe the technical solutions in the embodiments of the present invention more clearly, below will be to embodiment or description of the prior art
Needed in attached drawing be briefly described, it should be apparent that, the accompanying drawings in the following description is only of the invention some
Embodiment for those of ordinary skill in the art without any creative labor, can also be according to these
Attached drawing obtains other attached drawings.
Fig. 1 is the structure chart of biological detection platform provided in an embodiment of the present invention；
Fig. 2 is the explosive view of biological detection platform provided in an embodiment of the present invention；
Fig. 3 is the structure chart of anti-blood stains plug provided in an embodiment of the present invention；
Fig. 4 is the structure chart one of upper cover plate provided in an embodiment of the present invention；
Fig. 5 is the structure chart two of upper cover plate provided in an embodiment of the present invention；
Fig. 6 is the structure chart one of overflow plate provided in an embodiment of the present invention；
Fig. 7 is the structure chart two of overflow plate provided in an embodiment of the present invention；
Fig. 8 is the structure chart of the first filter plate provided in an embodiment of the present invention；
Fig. 9 is the structure chart of second of filter plate provided in an embodiment of the present invention；
Figure 10 is the structure chart of the third filter plate provided in an embodiment of the present invention；
Figure 11 is the structure chart of test board provided in an embodiment of the present invention；
Figure 12 is the structure chart one of bottom plate provided in an embodiment of the present invention；
Figure 13 is the structure chart two of bottom plate provided in an embodiment of the present invention.
Wherein, each appended drawing reference in figure:
100- cover assembly；The anti-blood stains plug of 1-；11- plug；12- pulls portion；2- upper cover plate；201- buffer inlet；
202- sample entrance port；203- gas vent；204- escape groove；The first block button hole of 205-；21- buckle；22- antiskid particles；23- water conservancy diversion
Portion；300- flow channel component；3- overflow plate；301- avoid holes；The second block button hole of 302-；31- buffers sap cavity；311- propulsive liquid mouth；
312- water conservancy diversion microtrabeculae；32- fluid channel；3201- reacts mouth；3202- sample inflow hole；321- the first choked flow boss；322- is non-return
Valve；323- the second choked flow boss；33- waste liquid chamber；34- circumferential rib；4- filter plate；401- sample runner；5- test board；51- inspection
Survey portion；52- signal contact；6- bottom plate；601- card slot；The hand-held part 602-；603- locating slot；61- limiting section.
Specific embodiment
In order to which technical problems, technical solutions and advantages to be solved are more clearly understood, tie below
Accompanying drawings and embodiments are closed, the present invention will be described in further detail.It should be appreciated that specific embodiment described herein is only
To explain the present invention, it is not intended to limit the present invention.
It should be noted that it can be directly another when element is referred to as " being fixed on " or " being set to " another element
On one element or indirectly on another element.When an element is known as " being connected to " another element, it can
To be directly to another element or be indirectly connected on another element.
It is to be appreciated that term " length ", " width ", "upper", "lower", "front", "rear", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "top", "bottom" "inner", "outside" is that orientation based on the figure or position are closed
System, is merely for convenience of description of the present invention and simplification of the description, rather than the device or element of indication or suggestion meaning must have
Specific orientation is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.
In addition, term " first ", " second " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include one or more of the features.In the description of the present invention, the meaning of " plurality " is two or more,
Unless otherwise specifically defined.
Fig. 1 and Fig. 2 is please referred to, now biological detection platform provided by the invention is illustrated.The biological detection platform packet
Include cover assembly 100, flow channel component 300, test board 5 and bottom plate 6, cover assembly 100, flow channel component 300, test board 5 and bottom
Plate 6 is cascading.Cover assembly 100 has the entrance flowed into for sample and buffer, and flow channel component 300 is offered for sample
The runner of this and buffer flowing, test board 5 and runner circulate, and test board 5 is for detecting sample.Cover assembly 100 and runner
Component 300 abuts against the sealing to be formed to runner.Sample and buffer are entered in flow channel component 300 by entrance, buffer liquid stream
When entering in test board 5, buffer cleans test board 5, and when sample is flowed into test board 5, test board 5 surveys sample
Examination.Wherein, sample can be the biological samples such as blood, urine, saliva.Test board 5 can be selected according to specific required detection function,
Protein, small molecule, nucleic acid, biomarker etc. in detectable biological sample.Cover assembly 100 detachably connects with bottom plate 6
It connects, flow channel component 300 and test board 5 are located between cover assembly 100 and bottom plate 6, and before test, buffer passes through upper cover
The entrance of component 100 enters flow channel component 300, enters back into flushing test board 5 in test board 5, after the completion of flushing, sample enters survey
In test plate (panel) 5, test board 5 detects sample, and buffer is reused after detection and rinses test board 5.In this embodiment,
Cover assembly 100 and bottom plate 6 are detachable, after the two disassembly, can respectively to cover assembly 100, flow channel component 300, test board 5,
Bottom plate 6 etc. carries out classification recycling and classified storage.
Biological detection platform provided by the invention, compared with prior art, biological detection platform of the present invention includes for sample
And the flow channel component 300 that flows into of buffer and test board 5 for test sample, cover assembly 100 and bottom plate 6 are by runner
Component 300 and test board 5 are fixed in the biological detection platform, and cover assembly 100 and bottom plate 6 are detachably connected, and are being used
After the biological detection platform, cover assembly 100 and bottom plate 6 can be separated, the biological detection platform structure is simple, production cost is low
And it is convenient for disassembly and assembly, therefore, cover assembly 100, bottom plate 6 and test board 5 after disassembly separation will not generate pollution ring when discarded
The case where border, can protect environment in order to avoid causing bacterium and virus infection before incineration process.
In one of the embodiments, please see Fig. 2 to Fig. 4, one kind as biological detection platform provided by the invention
Specific embodiment, cover assembly 100 include upper cover plate 2 and anti-blood stains plug 1, and entrance is opened in upper cover plate 2, and anti-blood stains plug 1 is set
In entrance.Wherein, anti-blood stains plug 1 is made of the flexible material such as flexible glue, can be by entrance when being filled in entrance
Sealing, avoids the sample contamination other component in such as sample, prevents the gas in gas injection from leaking.The side of anti-blood stains plug 1 has
Portion 12 is pulled, is made it easy to for pulling open or filling in, and then convenient for the user to operate, promotion user experience.Upper cover plate 2 opens up
There are above-mentioned entrance, buffer and sample from the runner for being directly entered flow channel component 300 in entrance, upper cover plate 2 and flow channel component
300 abut against, and seal upper cover plate 2 by the top of runner.
Fig. 3 to Fig. 7 is please referred in one of the embodiments, one kind as biological detection platform provided by the invention
Specific embodiment, the entry number of upper cover plate 2 are two, respectively sample entrance port 202 and buffer inlet 201, each runner group
Part 300 includes overflow plate 3, offers buffer runner on overflow plate 3, buffer inlet 201 is connected to buffer runner.Overflow
Plate 3 can be made of flexible glue.In this embodiment, correspondingly, there are two plugs 11 for tool on anti-blood stains plug 1, fill in sample respectively and enter
In mouth 202 and buffer inlet 201.Sample entrance port 202 enters for sample, and buffer inlet 201 enters for buffer, buffer
Entrance 201 is connected to buffer runner, and buffer can flow into buffer runner by buffer inlet 201, is then rinsed and is surveyed
Test plate (panel) 5 etc..
Fig. 2 and Fig. 8 is please referred in one of the embodiments, one kind as biological detection platform provided by the invention
Specific embodiment, flow channel component 300 further include the filter plate 4 for sample of dialysing, and offer on filter plate 4 and circulate for sample
Sample runner 401, the entrance of sample runner 401 is connected to sample entrance port 202, and the outlet of sample runner 401 and test board 5 connect
It is logical.Buffer runner and sample runner 401 collectively constitute above-mentioned runner.The effect of filter plate 4 is sample of dialysing, such as sample
When this is blood, accumulate haemocyte in sample runner 401, the cell unrelated with detection project of dialysing.Sample passes through entrance
Into in filter plate 4, after the dialysis of filter plate 4, into test board 5, sample is tested.
Optionally, the overflow plate 3 in flow channel component 300 abuts setting, the filter plate 4 in flow channel component 300 with upper cover plate 2
Setting is abutted with overflow plate 3, and filter plate 4 and test board 5 are set to the same side of overflow plate 3, overflow plate 3 is set to 2 He of upper cover plate
Between test board 5.In this way, being needed by sample entrance port 202, on overflow plate 3, overflow plate 3 when sample enters filter plate 4
Avoid holes 301 are offered, avoid holes 301 and the entrance of sample entrance port 202 and sample runner 401 face, and sample is kept away by this
Hole 301 is allowed to enter in sample runner 401.
Referring to Fig. 8, having sample runner 401 on filter plate 4, sample runner 401 can be S-shaped.Further, sample
Runner 401 can be inverted structure, i.e. sample runner 401 is gradually increased from its entrance to the width of outlet, to increase haemocyte
Sedimentation rate.Filter plate 4 is whole to be chosen as being made of transparent or translucent material material, is facilitated in observation filter plate 4
Situation.It in another embodiment, further include the storage being connected to runner referring to Fig. 9, filter plate 4a has sample runner 401a
Chamber 402, convenient for storing the haemocyte etc. of residual packing.In another embodiment, referring to Fig. 10, filter plate 4b has sample flow
Road 401b and sample runner 401c, sample runner 401b are identical with the entrance and exit of sample runner 401c, multiple sample runners
401 design can promote the efficiency and effect of sample dialysis.The structure and quantity of sample runner 401 herein without limitation, including
It is not limited to above-mentioned three kinds of situations.Optionally, it is 40 μ l to 60 μ l that sample runner 401, which quantifies reservoir volume,.
Fig. 5 to Figure 13 is please referred in one of the embodiments, one kind as biological detection platform provided by the invention
Specific embodiment, upper cover plate 2 have buckle 21 towards 6 side of bottom plate, and the card slot for 21 clamping of buckle is offered on bottom plate 6
601.The buckle 21 of upper cover plate 2 passes through the inner space of the biological detection platform and the card slot 601 of bottom plate 6 is clamped, and is needing to tear open
When unloading rear upper cover plate 2 and bottom plate 6, stirring buckle 21 can be such that upper cover plate 2 and bottom plate 6 is detached from, and by overflow plate 3, filter plate 4 and survey
Test plate (panel) 5 is removed.Specifically, card slot 601 is through slot, makes user that can stir buckle 21 in the outside of bottom plate 6.Optionally, 21 are buckled
Extending direction and upper cover plate 2 where plane it is vertical, make buckle 21 that can bear stronger active force in the vertical direction.At it
In middle one embodiment, the first block button hole 205 is offered on overflow plate 3, the second block button hole 302 is offered on test board 5, is buckled
21 pass through the first block button hole 205 of overflow plate 3, the second block button hole 302 and the card slot 601 of test board 5 are clamped；In another embodiment
In, buckle 21 passes through overflow plate 3 and filter plate 4 and 21 clamping of buckle；In another embodiment, the first card is not set on overflow plate 3
Button hole 205, buckle 21 passes through the edge of overflow plate 3 and bottom plate 6 is clamped.The quantity of buckle 21 is chosen as multiple, buckles 21
Distribution is not construed as limiting herein.
Optionally, bottom plate 6 towards 2 side of upper cover plate have multiple limiting sections 61, limiting section 61 for position filter plate 4,
Test board 5 and overflow plate 3, each limiting section 61 are arranged in respectively in filter plate 4, test board 5 and overflow plate 3.For example, part limits
Position portion 61 sequentially passes through filter plate 4 and overflow plate 3, and part limiting section 61 sequentially passes through test board 5 and overflow plate 3, realizes to mistake
The positioning of filter plate 4, test board 5 and overflow plate 3.Limiting section 61 is chosen as cylinder, and quantity is not construed as limiting herein.
Fig. 6 and Fig. 7 is please referred in one of the embodiments, one kind as biological detection platform provided by the invention
Specific embodiment, buffer runner include the buffering sap cavity 31 faced with buffer inlet 201, with buffering sap cavity 31 be connected to
Fluid channel 32, the waste liquid chamber 33 that is connected to fluid channel 32, the bottom wall of fluid channel 32, which is offered, flows into test board 5 for buffer
React mouth 3201.After buffer enters buffering sap cavity 31, fluid channel 32 is flowed into, test board 5 is flowed by reaction mouth 3201, rinses
Waste liquid chamber 33 is flowed into after test board 5.Optionally, buffering 31 inlet of sap cavity has propulsive liquid compatible with buffer inlet 201
Mouth 311 is tightly connected the side wall of the side wall for buffering sap cavity 31 and buffer inlet 201.Optionally, the quantity of mouth 3201 is reacted
To be multiple, the length direction along fluid channel 32 is sequentially distributed.
Optionally, it buffers and is equipped with water conservancy diversion microtrabeculae 312 at the entrance and exit of sap cavity 31, the quantity of water conservancy diversion microtrabeculae 312 is
Multiple and be spaced apart, the effect of water conservancy diversion microtrabeculae 312 is to increase the homogeneity of liquid flowing, has certain guiding to liquid
Effect.Water conservancy diversion microtrabeculae 312 can be cylindrical, and depth is less than or equal to the depth of buffering sap cavity 31.When water conservancy diversion microtrabeculae 312 is in
When cylindrical, the ratio of the height of water conservancy diversion microtrabeculae 312 and its diameter in 1:1 between 1:5, diameter and the phase of water conservancy diversion microtrabeculae 312
Spacing ratio between adjacent water conservancy diversion microtrabeculae 312 in 1:0.5 between 1:1, the cross-sectional area and buffering sap cavity 31 of water conservancy diversion microtrabeculae 312
Area ratio between 3% to 15%.More specifically, the width of the entrance and exit of buffering sap cavity 31 is respectively less than central cavity
Width, first is that can guarantee the capacity of buffering sap cavity 31, second is that being more convenient for controlling flow.
Optionally, the outlet place of facing of overflow plate 3 and sample runner 401 offers sample inflow hole 3202, sample flow
When entering the setting in hole 3202 so that sample flows to sample exit port, enter in fluid channel 32 by sample inflow hole 3202, then from
Enter in test board 5 in the reaction mouth 3201 of 32 bottom of fluid channel.More specifically, sample inflow hole 3202 is set to fluid channel 32
Inlet.
Optionally, the depth of fluid channel 32 is less than the depth of buffering sap cavity 31, in this way, when buffer is full of buffering sap cavity 31
When, Cai Huixiang fluid channel 32 flows, first is that the side wall of fluid channel 32 is rinsed as much as possible, second is that buffer can be precisely controlled
Flow is convenient for quantitative detection.The depth of fluid channel 32 is less than the depth of waste liquid chamber 33, so that the liquid in waste liquid chamber 33 will not
Towards 32 adverse current of fluid channel, guarantee the accuracy of testing result.
Optionally, the inlet of fluid channel 32 is provided with the first choked flow boss 321, prevents the liquid reflux in fluid channel 32
Into buffering sap cavity 31, the first choked flow boss 321 can be positive the protrusion that arc-shaped, ellipse arc or corner are arc, high
Degree is higher than the depth of fluid channel 32, and the first choked flow boss 321 is across the two sides of fluid channel 32, the height of the first choked flow boss 321
The ratio of degree and 32 whole height of fluid channel is between 5/10 to 9/10.It is convex that the exit of fluid channel 32 is provided with the second choked flow
Platform 323 prevents the liquid reflux in waste liquid chamber 33 into fluid channel 32, and the second choked flow boss 323 can be positive arc-shaped, elliptic arc
Shape or corner are the protrusion of arc, and height is higher than the depth of fluid channel 32, and the second choked flow boss 323 is also across fluid channel
32 two sides, the ratio of 32 whole height of height and fluid channel of the second choked flow boss 323 is between 5/10 to 9/10.
Optionally, check (non-return) valve 322 is additionally provided between fluid channel 32 and buffer chamber 31, the width of check (non-return) valve 322 is less than micro-
The width of runner 32, so that the liquid in fluid channel 32 can not flow back.Optionally, the width of check (non-return) valve and 32 width of fluid channel
Ratio is between 1/12 to 6/12.Overflow plate 3 not only has check (non-return) valve 322 in one of the embodiments, but also has the first choked flow
Boss 321, the liquid in dual guarantee fluid channel 32 will not be back in buffering sap cavity 31.Certainly, in other embodiments, overflow
Flowing plate 3 can also only include the first choked flow boss 321 or check (non-return) valve 322.
In one of the embodiments, referring to Fig. 7, a kind of specific reality as biological detection platform provided by the invention
Mode is applied, overflow plate 3 has the circumferential rib 34 for being located on reaction mouth 3201, circumferential rib 34 and test board 5 towards 5 side of test board
It abuts against, the effect of circumferential rib 34 is: being abutted against with test board 5, liquid is made to enter the channel of test board 5 from reaction mouth 3201
Sealing, prevents buffer from leaking, and in assembly, does not need to melt connection overflow plate 3 and test board using chemical reagent such as glue
5, convenient disassembly.Specifically, the border of each reaction mouth 3201 is provided with a circumferential rib 34, alternatively, being arranged on overflow plate 3
There is a circumferential rib 34, which is centered around around all reaction mouths 3201.Optionally, the height and width of circumferential rib 34
The ratio of degree is in 1:1 between 1:5.The shape of circumferential rib 34 is not construed as limiting herein, can be around reaction mouth 3201.
In one of the embodiments, referring to Fig. 5, a kind of specific reality as biological detection platform provided by the invention
Mode is applied, upper cover plate 2 also has the diversion division 23 protruded into reaction mouth 3201 towards 6 side of bottom plate, so that buffer is passing through
When reacting in the inflow test board 5 of mouth 3201, change the flow direction of buffer, guidance buffer flows into test board 5, enhancing pair
The cleaning effect of test board 5.23 external dimensions of diversion division is less than the size of reaction mouth 3201, makes buffer from reaction mouth 3201
It is flowed between inner wall and the outer wall of diversion division 23 in test board 5.
Optionally, in upper cover plate 2 sample entrance port 202 the chamfered setting of inner wall, bootable sample enters in runner, more
Body, when sample is blood, the injection members such as finger tip blood, dropper can be used to inject blood in runner.
Optionally, gas vent 203 is also provided on upper cover plate 2, gas vent 203 is faced with waste liquid chamber 33, prevents liquid
When into overflow plate 3, the air pressure in buffer runner is excessive, causes liquid that can not inject.
In one of the embodiments, referring to Fig. 5, a kind of specific reality as biological detection platform provided by the invention
Mode is applied, the surface of upper cover plate 2 has antiskid particles 22, and antiskid particles 22 are made of multiple protrusions.The effect of antiskid particles 22
It is: when pressing at this, can prevents entire biological detection platform from shaking, guarantee its stability.
Optionally, it is transparent or translucent to export the part faced for upper cover plate 2 and sample runner 401, convenient for from
Whether external observation sample occupies sample runner 401, is chosen as more specifically, filter plate 4 is whole by transparent or translucent material
The material of matter is made, and facilitates the situation in observation filter plate 4.
Optionally, test board 5 include with the test section 51 that reacts 3201 face of mouth, the quantity of test section 51 with react mouth
3201 quantity is identical.Test board 5 further includes signal contact 52, and the bio signal after signal contact 52 will test is transformed into telecommunications
Number, and it is transmitted to external display lamp or display, to read testing result.
Optionally, signal contact 52 is set to the edge of test board 5.Upper cover plate 2 is opened up with 53 place of facing of signal contact
Have escape groove 204, make signal contact 52 on the outer surface of the biological detection platform, convenient for signal contact 52 and external power supply or
The electrical connection of person's detection device.
Figure 12 and Figure 13 is please referred in one of the embodiments, and the side of bottom plate 6 has hand-held part 602, hand-held part
602 facilitate user to hold, and promote user experience.More specifically, the arc-shaped setting in the surface of hand-held part 602, is more bonded with hand.
Optionally, Figure 13 is please referred to, the outer wall of bottom plate 6 offers locating slot 603, the locating slot 603 and other components
It is engaged by clamping, when sliding entire biological detection platform to locating slot 603 and the clamping of other components, that is, reaches default position
It sets, the setting of locating slot 603 positions the biological detection platform convenient for user.The number of locating slot 603 and distribution do not limit herein
It is fixed.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. biological detection platform characterized by comprising
Cover assembly has the entrance flowed into for sample and buffer；
Flow channel component offers the runner for sample and buffer flowing；
Test board is connected to and for detecting sample with the runner；
Bottom plate is detachably connected with the cover assembly；
Wherein, the cover assembly, the flow channel component, the test board, the bottom plate are cascading.
2. biological detection platform as described in claim 1, which is characterized in that the cover assembly includes upper cover plate and anti-blood stains
Plug, the entrance are opened in the upper cover plate, and the anti-blood stains plug is set in the entrance.
3. biological detection platform as claimed in claim 2, which is characterized in that the upper cover plate has towards the bottom plate side
It buckles, the card slot for the buckle clamping is offered on the bottom plate.
4. biological detection platform as claimed in claim 2, which is characterized in that the entry number of the upper cover plate is two, point
Not Wei sample entrance port and buffer inlet, the flow channel component includes overflow plate, buffer runner is offered on the overflow plate,
The buffer inlet is connected to the buffer runner.
5. biological detection platform as claimed in claim 4, which is characterized in that the buffer runner includes and the buffer
Buffering sap cavity that entrance faces, the fluid channel being connected to the buffering sap cavity, the waste liquid chamber being connected to the fluid channel, it is described
The bottom wall of fluid channel offers the reaction mouth that the test board is flowed into for buffer.
6. biological detection platform as claimed in claim 5, which is characterized in that the upper cover plate also has towards the bottom plate side
There is the diversion division protruded into the reaction mouth.
7. biological detection platform as claimed in claim 5, which is characterized in that the overflow plate has towards the test board side
There is the circumferential rib for being located on the reaction mouth, the circumferential rib is abutted against with the test board.
8. biological detection platform as claimed in claim 4, which is characterized in that the flow channel component further includes for sample of dialysing
Filter plate, offer the sample runner for sample circulation on the filter plate, the entrance of the sample runner with it is described
Sample entrance port connection, the outlet of the sample runner is connected to the test board.
9. biological detection platform as claimed in claim 2, which is characterized in that the surface of the upper cover plate has antiskid particles.
10. biological detection platform as described in claim 1, which is characterized in that the side of the bottom plate has hand-held part.
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| CN201811512802.5A CN109967138B (en) | 2018-12-11 | 2018-12-11 | Biological detection platform |
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| CN201811512802.5A CN109967138B (en) | 2018-12-11 | 2018-12-11 | Biological detection platform |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113008959A (en) * | 2021-02-26 | 2021-06-22 | 深圳市西尔曼科技有限公司 | Test electrode, electrode module and detection system |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106119085A (en) * | 2016-08-23 | 2016-11-16 | 闫维新 | A kind of real-time fluorescence PCR mixing microchannel chip |
| CN205720234U (en) * | 2016-03-16 | 2016-11-23 | 杭州安旭科技有限公司 | A kind of collection and detection device of sample |
| CN107126753A (en) * | 2017-05-25 | 2017-09-05 | 苏州岚轩生物科技有限公司 | Active micro-fluidic chip and its Whole Blood Filtration device |
| CN107737615A (en) * | 2017-09-20 | 2018-02-27 | 南京肯辛顿诊断科技有限公司 | A kind of microfluidic device for biochemistry detection |
| CN207908375U (en) * | 2018-02-09 | 2018-09-25 | 广东达元绿洲食品安全科技股份有限公司 | A kind of cover buckle formula organophosphate and carbamate pesticide residual rapidly measuring device |
| CN209680120U (en) * | 2018-12-11 | 2019-11-26 | 上海微瑞博生物科技有限公司 | Biological detection platform |
-
2018
- 2018-12-11 CN CN201811512802.5A patent/CN109967138B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205720234U (en) * | 2016-03-16 | 2016-11-23 | 杭州安旭科技有限公司 | A kind of collection and detection device of sample |
| CN106119085A (en) * | 2016-08-23 | 2016-11-16 | 闫维新 | A kind of real-time fluorescence PCR mixing microchannel chip |
| CN107126753A (en) * | 2017-05-25 | 2017-09-05 | 苏州岚轩生物科技有限公司 | Active micro-fluidic chip and its Whole Blood Filtration device |
| CN107737615A (en) * | 2017-09-20 | 2018-02-27 | 南京肯辛顿诊断科技有限公司 | A kind of microfluidic device for biochemistry detection |
| CN207908375U (en) * | 2018-02-09 | 2018-09-25 | 广东达元绿洲食品安全科技股份有限公司 | A kind of cover buckle formula organophosphate and carbamate pesticide residual rapidly measuring device |
| CN209680120U (en) * | 2018-12-11 | 2019-11-26 | 上海微瑞博生物科技有限公司 | Biological detection platform |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113008959A (en) * | 2021-02-26 | 2021-06-22 | 深圳市西尔曼科技有限公司 | Test electrode, electrode module and detection system |
| CN113008959B (en) * | 2021-02-26 | 2022-07-15 | 深圳市西尔曼科技有限公司 | Test electrode, electrode module and detection system |
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| CN109967138B (en) | 2021-11-05 |
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