CN109923102B - 普利多匹定用于治疗功能下降的用途 - Google Patents

普利多匹定用于治疗功能下降的用途 Download PDF

Info

Publication number
CN109923102B
CN109923102B CN201780066778.4A CN201780066778A CN109923102B CN 109923102 B CN109923102 B CN 109923102B CN 201780066778 A CN201780066778 A CN 201780066778A CN 109923102 B CN109923102 B CN 109923102B
Authority
CN
China
Prior art keywords
twice
pridopidine
day
patient
baseline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780066778.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN109923102A (zh
Inventor
迈克尔·海登
史派瑞顿·帕帕佩特罗普洛斯
尤哈-马蒂·萨福拉
伊莱·埃亚勒
贝丝·博罗夫斯基
伊戈尔·D·格拉切夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prenia Medical Development Co ltd
Prenia Neurotherapy Co ltd
Original Assignee
Prenia Medical Development Co ltd
Prenia Neurotherapy Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prenia Medical Development Co ltd, Prenia Neurotherapy Co ltd filed Critical Prenia Medical Development Co ltd
Priority to CN202211419342.8A priority Critical patent/CN115671103A/zh
Publication of CN109923102A publication Critical patent/CN109923102A/zh
Application granted granted Critical
Publication of CN109923102B publication Critical patent/CN109923102B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780066778.4A 2016-08-24 2017-08-24 普利多匹定用于治疗功能下降的用途 Active CN109923102B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211419342.8A CN115671103A (zh) 2016-08-24 2017-08-24 普利多匹定用于治疗功能下降的用途

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662379175P 2016-08-24 2016-08-24
US62/379,175 2016-08-24
US201662395263P 2016-09-15 2016-09-15
US62/395,263 2016-09-15
US201662411511P 2016-10-21 2016-10-21
US62/411,511 2016-10-21
US201662416685P 2016-11-02 2016-11-02
US62/416,685 2016-11-02
PCT/US2017/048461 WO2018039477A1 (en) 2016-08-24 2017-08-24 Use of pridopidine for treating functional decline

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202211419342.8A Division CN115671103A (zh) 2016-08-24 2017-08-24 普利多匹定用于治疗功能下降的用途

Publications (2)

Publication Number Publication Date
CN109923102A CN109923102A (zh) 2019-06-21
CN109923102B true CN109923102B (zh) 2022-11-15

Family

ID=61241181

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780066778.4A Active CN109923102B (zh) 2016-08-24 2017-08-24 普利多匹定用于治疗功能下降的用途
CN202211419342.8A Pending CN115671103A (zh) 2016-08-24 2017-08-24 普利多匹定用于治疗功能下降的用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202211419342.8A Pending CN115671103A (zh) 2016-08-24 2017-08-24 普利多匹定用于治疗功能下降的用途

Country Status (17)

Country Link
US (1) US11207310B2 (https=)
EP (2) EP4516356A3 (https=)
JP (2) JP6912574B2 (https=)
CN (2) CN109923102B (https=)
AU (2) AU2017315783C1 (https=)
BR (1) BR112019003732A2 (https=)
CA (2) CA3035092C (https=)
CL (2) CL2019000485A1 (https=)
DK (1) DK3504187T3 (https=)
ES (1) ES3025836T3 (https=)
FI (1) FI3504187T3 (https=)
HU (1) HUE071008T2 (https=)
IL (1) IL311081A (https=)
MX (2) MX390627B (https=)
PL (1) PL3504187T3 (https=)
PT (1) PT3504187T (https=)
WO (1) WO2018039477A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013536825A (ja) 2010-09-03 2013-09-26 イバックス・インターナショナル・ゲーエムベーハー ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体
US11090297B2 (en) 2013-06-21 2021-08-17 Prilenia Neurotherapeutics Ltd. Pridopidine for treating huntington's disease
HK1221646A1 (zh) * 2013-06-21 2017-06-09 Teva Pharmaceuticals International Gmbh 高剂量普利多匹定用於治疗亨廷顿舞蹈症的用途
TW201613859A (en) * 2014-06-30 2016-04-16 Teva Pharma Analogs of PRIDOPIDINE, their preparation and use
JP6887952B2 (ja) 2015-02-25 2021-06-16 プリレニア ニューロセラピューティクス リミテッド 認知機能を改善するため、およびアルツハイマー病を治療するためのプリドピジンの使用
US11471449B2 (en) 2015-02-25 2022-10-18 Prilenia Neurotherapeutics Ltd. Use of pridopidine to improve cognitive function and for treating Alzheimer's disease
CA3035099C (en) * 2016-08-24 2023-01-17 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating dystonias
EP4516356A3 (en) 2016-08-24 2025-05-14 Prilenia Neurotherapeutics Ltd. Use of pridopidine for treating functional decline
AU2017327539B2 (en) 2016-09-15 2020-12-24 Boehringer Ingelheim International Gmbh Heteroaryl carboxamide compounds as inhibitors of RIPK2
US12102627B2 (en) 2016-09-16 2024-10-01 Prilenia Neurotherapeutics Ltd. Use of pridopidine for treating rett syndrome
JP2020533296A (ja) 2017-09-08 2020-11-19 プリレニア ニューロセラピューティクス リミテッド 薬物誘発性ジスキネジアを治療するためのプリドピジン
US12036213B2 (en) 2017-09-08 2024-07-16 Prilenia Neurotherapeutics Ltd. Pridopidine for treating drug induced dyskinesias
WO2020157083A1 (en) * 2019-01-31 2020-08-06 F. Hoffmann-La Roche Ag Assessing progression of huntington's disease
CN113395964A (zh) 2019-02-04 2021-09-14 普瑞尼亚神经治疗有限公司 用于帕金森氏病和与帕金森症相关的其它疾病的低剂量普利多匹定
CN121243170A (zh) 2019-06-12 2026-01-02 普瑞尼亚神经治疗有限公司 用于治疗亨廷顿病及其症状的包含普利多匹定及其类似物的组合物
CA3176917A1 (en) * 2020-05-04 2021-11-11 Prilenia Neurotherapeutics Ltd. Treatment of viral infection, disease or disorder using a selective s1r agonist
IL307462A (en) * 2021-04-14 2023-12-01 Prilenia Neurotherapeutics Ltd Treatment of prodromal huntington disease
WO2025164698A1 (ja) * 2024-01-31 2025-08-07 株式会社ケイファーマ ハンチントン病治療剤及び治療用組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105592848A (zh) * 2013-06-21 2016-05-18 梯瓦制药国际有限责任公司 高剂量普利多匹定用于治疗亨廷顿舞蹈症的用途

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702716D0 (sv) 1997-07-15 1997-07-15 Ross Nicholas Waters Substituted phenylazacycloalkanes in the treatment of cognitive disorders
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
SE9904724D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
EP1713486A4 (en) * 2003-12-02 2009-04-29 Sheldon Leslie James COMBINED THERAPY FOR THE TREATMENT OF DEMENTIA, DEPRESSION AND APATHY
GT200500063A (es) 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
CA2584831C (en) 2004-10-13 2013-09-17 Neurosearch Sweden Ab Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
PE20071092A1 (es) 2005-12-08 2007-12-10 Aventis Pharma Inc Composicion farmaceutica que comprende un antagonista de cb1 y un agente antisicotico
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
US20070286902A1 (en) 2006-06-07 2007-12-13 Abrika Pharmaceuticals Dosage forms comprising a short acting sedative-hypnotic or salt thereof
CN101711236B (zh) 2007-04-12 2012-10-31 Nsab神经研究瑞典公司分公司 表现出改善的心血管副作用特性的多巴胺受体稳定剂/调节剂的n-氧化物和/或二-n-氧化物衍生物
US8669048B2 (en) * 2008-06-24 2014-03-11 Parkinson's Institute Pluripotent cell lines and methods of use thereof
US8384755B2 (en) 2009-08-26 2013-02-26 Intouch Technologies, Inc. Portable remote presence robot
US8852631B2 (en) 2009-09-24 2014-10-07 Capsugel Belgium Nv Acid resistant capsules
US20110206782A1 (en) 2010-02-24 2011-08-25 Auspex Pharmaceuticals, Inc. Piperidine modulators of dopamine receptor
WO2011107583A1 (en) 2010-03-04 2011-09-09 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders
JP2013532233A (ja) 2010-07-02 2013-08-15 アクティエボラゲット・エスコーエッフ 機械構成要素、および表面硬化方法
JP2013536825A (ja) 2010-09-03 2013-09-26 イバックス・インターナショナル・ゲーエムベーハー ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体
US8703763B2 (en) 2011-03-02 2014-04-22 Hoffmann-La Roche Inc. Bridged piperidine derivatives
WO2012159079A1 (en) 2011-05-18 2012-11-22 The Parkinson's Institute Assay to determine lrrk2 activity in parkinson's disease
BR112014005389A8 (pt) 2011-09-07 2018-04-03 Ivax Int Gmbh Sal cloridrato de 4- (3-metanossulfonil-fenil) -1- propil-piperidina em uma forma cristalina, composição farmacêutica compreendendo o mesmo e usos do dito sal
TWI579272B (zh) * 2011-12-08 2017-04-21 梯瓦製藥國際有限責任公司 普多比啶（ｐｒｉｄｏｐｉｄｉｎｅ）之氫溴酸鹽
US9744155B2 (en) * 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
AU2013243461A1 (en) 2012-04-04 2014-11-06 Teva Pharmaceuticals International Gmbh Pharmaceutical compositions for combination therapy
US20150216850A1 (en) 2012-09-27 2015-08-06 Michael Hayden Combination of rasagiline and pridopidine for treating neurodegenerative disorders, in particular huntington's disease
MX2015003608A (es) 2012-09-27 2015-06-05 Teva Pharma Combinacion de laquinimod y pridopidina para tratar trastornos neurodegenerativos.
US11090297B2 (en) 2013-06-21 2021-08-17 Prilenia Neurotherapeutics Ltd. Pridopidine for treating huntington's disease
MX377576B (es) 2014-01-22 2025-03-04 Prilenia Neurotherapeutics Ltd Formulaciones de pridopidina de liberación modificada.
TW201613859A (en) 2014-06-30 2016-04-16 Teva Pharma Analogs of PRIDOPIDINE, their preparation and use
MX2017008136A (es) 2014-12-22 2018-03-06 Teva Pharmaceuticals Int Gmbh Sal de l-tartrato de pridopidina.
WO2016138135A1 (en) 2015-02-25 2016-09-01 Teva Pharmaceuticals International Gmbh Sigma-1 receptor modulators for treating huntington's disease
JP6887952B2 (ja) * 2015-02-25 2021-06-16 プリレニア ニューロセラピューティクス リミテッド 認知機能を改善するため、およびアルツハイマー病を治療するためのプリドピジンの使用
AR105434A1 (es) 2015-07-22 2017-10-04 Teva Pharmaceuticals Int Gmbh Proceso para preparar pridopidina
EP3324967A4 (en) 2015-07-22 2019-03-20 Prilenia Therapeutics Development Ltd. PRIDOPIDINE-BASED FORMULATIONS AND USE OF THE SAME
WO2017048457A1 (en) 2015-09-18 2017-03-23 Teva Pharmaceuticals Industries Ltd. Combination of laquinimod and pridopidine to treat multiple sclerosis
JP7034488B2 (ja) 2016-02-24 2022-03-14 プリレニア・ニューロセラピューティクス・エルティーディー プリドピジンを使用する神経変性眼疾患の治療
CA3035099C (en) 2016-08-24 2023-01-17 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating dystonias
EP4516356A3 (en) 2016-08-24 2025-05-14 Prilenia Neurotherapeutics Ltd. Use of pridopidine for treating functional decline
CN109952100A (zh) 2016-09-15 2019-06-28 普瑞尼亚医疗发展有限公司 普利多匹定用于治疗焦虑和抑郁的用途
HUE058314T2 (hu) 2016-09-16 2022-07-28 Prilenia Neurotherapeutics Ltd Pridopidin alkalmazása Rett-szindróma kezelésére
WO2018053275A1 (en) 2016-09-16 2018-03-22 Teva Pharmaceuticals International Gmbh Use of pridopidine for the treatment of familial dysautonomia
CA3050700C (en) 2017-01-20 2023-10-03 Prilenia Neurotherapeutics Ltd. Use of pridopidine for the treatment of fragile x syndrome
SI4154882T1 (sl) 2017-08-14 2026-01-30 Prilenia Neurotherapeutics Ltd. Zdravljenje amiotrofične lateralne skleroze s pridopidinom
CA3073568A1 (en) 2017-08-30 2019-03-07 Prilenia Neurotherapeutics Ltd. High concentration dosage forms of pridopidine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105592848A (zh) * 2013-06-21 2016-05-18 梯瓦制药国际有限责任公司 高剂量普利多匹定用于治疗亨廷顿舞蹈症的用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Dopamine and Huntington’s;Laetitia C Schwab et al;《Expert reviews》;20150316;第15卷(第4期);全文 *
亨廷顿氏病发病及基因诊断;王秀英等;《中国神经精神疾病杂志》;19980315;第24卷(第2期);全文 *

Also Published As

Publication number Publication date
JP6912574B2 (ja) 2021-08-04
EP3504187A1 (en) 2019-07-03
BR112019003732A2 (pt) 2020-02-18
MX2022003072A (es) 2022-06-17
AU2020223736A1 (en) 2020-09-17
EP3504187B1 (en) 2025-02-19
ES3025836T3 (en) 2025-06-09
JP2019524898A (ja) 2019-09-05
MX2019002265A (es) 2019-10-30
US11207310B2 (en) 2021-12-28
EP4516356A3 (en) 2025-05-14
JP2021119186A (ja) 2021-08-12
AU2017315783A1 (en) 2019-04-11
CN109923102A (zh) 2019-06-21
FI3504187T3 (fi) 2025-04-05
AU2017315783B2 (en) 2020-05-28
HUE071008T2 (hu) 2025-07-28
EP3504187A4 (en) 2020-05-06
AU2017315783C1 (en) 2020-12-24
CN115671103A (zh) 2023-02-03
PL3504187T3 (pl) 2025-06-09
PT3504187T (pt) 2025-05-09
AU2020223736B2 (en) 2022-04-07
CA3035092A1 (en) 2018-03-01
WO2018039477A1 (en) 2018-03-01
EP3504187B8 (en) 2025-03-26
EP4516356A2 (en) 2025-03-05
US20180055832A1 (en) 2018-03-01
CA3151507A1 (en) 2018-03-01
NZ751156A (en) 2021-01-29
DK3504187T3 (da) 2025-04-14
CL2019003924A1 (es) 2020-05-29
MX390627B (es) 2025-03-21
IL311081A (en) 2024-04-01
CA3151507C (en) 2024-05-28
CA3035092C (en) 2022-05-31
CL2019000485A1 (es) 2019-07-12

Similar Documents

Publication Publication Date Title
CN109923102B (zh) 普利多匹定用于治疗功能下降的用途
US12564582B2 (en) Use of pridopidine for treating dystonias
CN105592848A (zh) 高剂量普利多匹定用于治疗亨廷顿舞蹈症的用途
US20230181548A1 (en) Use of pridopidine for treating functional decline
HK40115915A (en) Use of pridopidine for treating functional decline
EA041256B1 (ru) Применение придопидина для лечения ухудшения функциональной способности
HK40009736A (en) Use of pridopidine for treating functional decline
HK40009736B (en) Use of pridopidine for treating functional decline
NZ751156B2 (en) Use of pridopidine for treating functional decline
NZ791717A (en) Use of pridopidine for treating functional decline

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: Herzliya

Applicant after: Prenia Neurotherapy Co.,Ltd.

Address before: Herzliya

Applicant before: Prenia Medical Development Co.,Ltd.

CB02 Change of applicant information
GR01 Patent grant
GR01 Patent grant