CN109908217B

CN109908217B - Traditional Chinese medicine composition for treating lower limb arteriosclerosis obliterans and application thereof

Info

Publication number: CN109908217B
Application number: CN201910308304.7A
Authority: CN
Inventors: 李军; 陈恒文; 武庆娟; 谭雨晴; 田盼盼; 高健
Original assignee: Guanganmen Hospital of CACMS
Current assignee: Guanganmen Hospital of CACMS
Priority date: 2019-04-17
Filing date: 2019-04-17
Publication date: 2022-03-01
Anticipated expiration: 2039-04-17
Also published as: CN109908217A

Abstract

The invention discloses a traditional Chinese medicine composition for treating arterial thrombosis obliterans, which is prepared from the raw materials of prepared aconite root, astragalus root, cassia twig, white peony root, peach kernel, safflower, leech, immature bitter orange, rhubarb, asarum and the like according to a certain weight ratio. The traditional Chinese medicine composition has obvious treatment effect on arterial thrombosis diseases, in particular to limb arteriosclerosis obliterans.

Description

Traditional Chinese medicine composition for treating lower limb arteriosclerosis obliterans and application thereof

Technical Field

The invention relates to a traditional Chinese medicine composition for treating arterial thrombosis occlusion and application thereof, belonging to the field of traditional Chinese medicines.

Background

Lower limb arteriosclerosis obliterans (ASO) is a chronic progressive disease caused by arterial blood vessel intimal thickening due to atherosclerosis, thrombosis, lumen stenosis or occlusion, and limb blood supply insufficiency, and clinically manifested by skin temperature reduction, pain, lower limb intermittent claudication, even ulcer or necrosis. According to epidemiological investigation, the morbidity of the patient is up to 15-20% in the population over 75 years old, and the annual fatality rate of the patient is 4-6%.

The ASO patients have high disability rate and high fatality rate, and great personal and social burden is caused. In terms of treatment, surgical methods, particularly percutaneous transluminal balloon dilatation/stenting accessed from the groin area, have become the first choice for treating this condition. Western medicine department mainly removes the causes of hypertension, hyperlipemia, smoking and the like, and adopts the methods of anti-platelet, anticoagulation, polymerization removal, blood vessel expansion and the like. In TCM, arteriosclerotic occlusion is classified into the categories of "blood stasis", "meridian obstruction", "non-meridian syndrome" and "blood stasis syndrome". The deficiency of healthy qi, the inability to promote and the insufficient warming, which lead to the hypofunction of the zang-fu organs, the dysfunction of the body fluids and blood and the disturbance of metabolism of substances, produce the pathological products of the hypofunction of the zang-fu organs, such as "phlegm-dampness" and "blood stasis", which are finally obstructed in the veins of the lower limbs. Therefore, the traditional Chinese medicine mainly has the functions of tonifying deficiency, eliminating turbid pathogen, removing blood stasis and eliminating phlegm in the traditional Chinese medicine treatment of the lower limb arteriosclerotic diseases, and addresses both the symptoms and root causes.

Disclosure of Invention

The invention aims to provide a novel traditional Chinese medicine composition which can be used for treating arterial occlusive diseases such as lower limb arteriosclerosis obliterans.

In order to realize the purpose of the invention, the inventor provides a traditional Chinese medicine composition, and the effective components of the composition are prepared from the following raw material medicines in proportion: 10-30 parts of prepared monkshood, 15-40 parts of astragalus, 9-30 parts of cassia twig, 5-10 parts of white paeony root, 6-12 parts of peach kernel, 6-12 parts of safflower, 1-3 parts of leech, 6-12 parts of immature bitter orange, 6-12 parts of rhubarb and 1-3 parts of asarum.

Preferably, the traditional Chinese medicine composition comprises the following raw material medicines in proportion: 20-30 parts of prepared monkshood, 20-35 parts of astragalus membranaceus, 9-20 parts of cassia twig, 8-10 parts of radix paeoniae alba, 8-10 parts of peach kernel, 8-10 parts of safflower, 2-3 parts of leech, 8-10 parts of immature bitter orange, 8-10 parts of rheum officinale and 2-3 parts of asarum.

Further preferably, the mixture ratio of each raw material medicine is as follows: 30 parts of prepared monkshood, 30 parts of astragalus, 9 parts of cassia twig, 10 parts of white paeony root, 9 parts of peach seed, 9 parts of safflower, 3 parts of leech, 9 parts of immature bitter orange, 9 parts of rhubarb and 3 parts of asarum.

The inventor thinks that blood runs warm and congeals in the cold, and congeals are the important cause of blood stasis and thrombus formation. Cold pathogen can cause slow blood flow and blood stasis due to blood stagnation; meanwhile, the cold pathogen causes contraction and spasm of the channels, and the dwarf of the bloodvessel is painful; cold is yin pathogen, which tends to damage yang qi, yang deficiency promotes blood weakness, aggravates thrombosis, and long-term obstruction of cold pathogen can damage yang to cause qi deficiency, which becomes a syndrome of deficiency-excess complication, with pain and debilitation as the main clinical manifestations. For treatment, yang-warming, qi-tonifying, cold-dispelling, blood-activating and stasis-resolving are used as the therapeutic methods. Thus, the inventors have devised a present invention in which: the monkshood and the astragalus are used as monarch drugs, the monkshood is pungent and sweet in flavor and hot in nature and is used for warming the kidney and supporting yang to dispel cold, the astragalus is sweet and warm and has special efficacy of tonifying qi, and the two drugs are used together to play the functions of warming yang and tonifying qi so as to warm and promote blood circulation; the cassia twig, the white paeony root, the peach kernel, the safflower and the cassia twig which are pungent and disperse and are warm and smooth are selected as ministerial drugs, and the monarch drug, namely the aconite which is pungent and warm is used for assisting in warming yang, the peach kernel and the safflower enter the heart and liver blood system, take on the pungent and warm properties, activate blood and remove stasis, the white paeony root which is sour and astringing yin, nourish blood and relieve pain; the immature bitter orange is added, the bitter orange is pungent and bitter to reduce, the qi is broken and the abdominal mass is dissipated, the rhubarb is pushed to be fresh, the stasis is removed and the channels are dredged, the blood stasis can be removed and the heat can be removed, the asarum is pungent and warm to flow away, the nine orifices are cleared, the leeches can flow away with drugs, the inside and the outside are reached, and the blood is broken and the stasis is removed. The formula can warm kidney and strengthen yang to dispel cold, invigorate qi and activate blood to remove blood stasis, and is good for treating arterial thrombosis diseases such as arterial thrombosis occlusion, limb arteriosclerosis occlusion and the like, belonging to patients with yang deficiency and blood stasis.

The purpose of the invention can be realized by applying the traditional Chinese medicine composition alone. In order to further enhance the applicability or improve the effect, other auxiliary medicines can be added according to the needs of clinical symptoms, the most common medicines are 8-10 parts of scorpion, 8-10 parts of common burreed rhizome and 8-10 parts of zedoary, and the preferred proportion of the last three medicines is 9: 9: 9.

when in use, the traditional Chinese medicine composition can be decocted with water according to the traditional usage of the prescription and taken as decoction. Or refining the effective components of the preparation with water or other suitable solvent, and making into various solid preparations such as tablet, capsule, granule, etc. by conventional preparation process.

Advantageous effects

The pharmaceutical composition is used as an in-hospital preparation, has obvious curative effect on arterial occlusive diseases caused by yang deficiency, congealing cold and blood stasis through effect verification of nearly thousands of clinical cases, and can achieve the purpose of treatment without being matched with western medicines. Especially for the elderly patients with deficiency of yang qi, the traditional Chinese medicine can achieve the treatment effect based on the principle and the target by improving the body function. The following are typical cases selected from the clinic.

1. First diagnosis of case-one X male 64 years old lower limb arteriosclerosis 2017/6/27

The main complaints are: the fatigue and pain of the two lower limbs are more than 3 years.

The following symptoms are marked: the two lower limbs are obvious in hypodynamia, the feet are painful, numb feelings can be caused, the rest is required to stop when the user walks for 10m on the flat ground, the two lower limbs feel cool, aversion to cold, the user can take the food, the sleep is poor, the stool is carried for one line in 2-3 days, the quality is dry, and the user can adjust the stool in a small way. Dark tongue with yellow and greasy coating and wiry and tense pulse.

Auxiliary inspection: double lower limb artery color ultrasound: severe stenosis of the right external iliac artery; left external iliac artery moderate stenosis, double lower limb ischemia stage II;

history of the past: after bypass surgery for more than 15 years for diabetes and more than 40 years for hypertension

And (3) Western diagnosis: post-operation of lower limb arteriosclerosis, carotid arteriosclerosis, coronary heart disease and CABG

Dialectical traditional Chinese medicine: congealing cold and blood stasis

Therapeutic method: warming yang, dispelling cold, promoting blood circulation and removing blood stasis

Prescription:

a basic method: 30g of prepared aconite root (firstly), 30g of astragalus root, 9g of cassia twig, 9g of peach kernel, 9g of safflower, 10g of white peony root, 3g of leech, 9g of immature bitter orange, 9g of rhubarb and 3g of asarum

Adding medicine: scorpio 9g, rhizoma Sparganii 9g, and Curcumae rhizoma 9g

Square solution: according to the tongue vessel, the patient has pain and numbness of limbs and dark tongue, which is the blood stasis and qi stagnation vessels blockage, so the blood stasis can be removed by adding the rhizoma sparganii, the rhizoma zedoariae and the scorpion which have strong blood breaking and qi moving strength on the basis of the original formula.

Re-diagnosis one 2017/7/25

The following symptoms are marked: after the medicine is taken, people can walk slowly and freely in the ground, pain and weakness are better than before, toes feel like before, the mouth is dry and the people want to drink, sweat easily, take the medicine, sleep well, defecate for 2 days, take the medicine, have a shape, have a slightly dry quality, defecate for a little effort, and urinate for a little time. Dark tongue with thin coating and deep pulse.

Prescription:

Adding medicine: dried ginger 9g, honey-fried licorice root 10g, achyranthes root 15g

Square solution: the first-dose prescription is 14, and the patient can walk in the lower part. According to the tongue pulse, although the pain and numbness of limbs are reduced, the symptoms are still in the tongue pulse, the congealing cold causes blood stasis and qi stagnation, the blood circulation is not smooth, and dried ginger and honey-fried licorice root are used for warming the interior and regulating the middle; for it can also make defecation hard, it is combined with niu xi to dispel blood stasis and induce menstruation, induce diuresis and treat stranguria.

Second diagnostic method 2017/8/22

The following symptoms are marked: after the patient wears the medicine, the pain of the lower limbs is improved obviously, the patient is not limited to walk, still feels hypodynamia, does not have chest distress and shortness of breath, does not have dizziness and headache, can sleep, defecate for 2 days, is dry and can urinate. Dark tongue with thin, yellow, greasy coating and deep pulse.

Prescription:

Square solution: for the tongue pulse, the patient has pain and pain in the limbs, and has not complained of special discomfort, so it is used 2017/7/25 days.

Three diagnostic methods 2017/9/19

The following symptoms are marked: the walking is free, the pain feeling almost disappears, the cold and numb feeling and the hypodynamia are better, the skin cold feeling is relieved, the chest distress and the chest pain are avoided, the gum swelling and pain are relieved, the sleep is safe, the stool is convenient for 3 days, and the quality is dry and small. Dark tongue with yellow and greasy coating and wiry and tense pulse

Prescription:

Square solution: according to the tongue pulse, the patient has pain and pain in the limbs, and has not complained of special discomfort, so he continues to use 2017/7/25 days.

Four diagnostic methods 2017/10/17

The following symptoms are marked: after the foot bath liquid is taken, people walk as usual, pain disappears, except for slight numbness of right soles, dry skin and pruritus, the people do not complain of special discomfort, take the foot bath liquid, have poor sleep and ease, and have stool for 2-3 days, dry texture and convenient adjustment. Dark tongue with yellow and greasy coating and wiry pulse.

Auxiliary inspection: double lower extremity arterial ultrasound (2017-9-21): arteriosclerosis of both lower limbs is accompanied with plaque formation, and deep veins of both lower limbs are not abnormal;

and (3) biochemical treatment: LDL 1.35, HDL 1.06, TG 0.73, glycated hemoglobin 6.1

Prescription:

Square solution: during the first diagnosis and in the four months, the patients take the formula for five times, during which no other medicines are taken, the pain of the lower limbs is gradually relieved until the pain disappears, and the patients walk on the ground as usual, the compatibility of the rest symptoms is improved and the rest symptoms are all good, the original formula is effective, so the patients continue to use the previous formula. If there is discomfort, follow the diagnosis.

2. Primary diagnosis 2017/7/25 of 70 years old female left lower limb arterial occlusion

The main complaints are: the fatigue and pain of the lower limbs of the patient are more than 2 years.

The following symptoms are marked: the two lower limbs are weak, the patient feels pain after walking for 10m, the hands and the feet are cool, the mouth is dry and not bitter, the patient can sleep conveniently, and the patient can walk conveniently. Dark tongue with thin coating and deep pulse.

Auxiliary inspection: double lower limb artery color ultrasound: occlusion of the right lower extremity artery, gross weight stenosis of the right thigh, moderate stenosis of the left superficial femoral artery, bilateral anterior tibial and left posterior arterial occlusion

And (3) Western diagnosis: arterial occlusion of lower limbs and hyperlipidemia

Dialectical traditional Chinese medicine: congealing cold and blood stasis

Prescription:

Adding medicine: scorpio 9g, rhizoma Sparganii 9g, and Curcumae rhizoma 9g

Square solution: the auxiliary examination indicates that the patients have limb arterial occlusion with severe stenosis, blood stasis and stagnation and pain, and poor nourishment and hypodynamia of lower limbs, which are caused by blood stasis and qi stagnation and vessel stasis, so the common burreed rhizome, the zedoary and the scorpion are used for assisting in breaking blood, promoting circulation of qi and removing stasis.

Re-diagnosis one 2017/8/22

The following symptoms are marked: after the user wears the shoes, the walking distance can be insisted to be increased compared with the walking distance before, the two lower limbs still have weakness, the right side is obvious, the hands and the feet are cool, the user can sleep for a long time, and the user can walk conveniently.

Prescription:

Square solution: according to the syndrome of cold accumulation in the tongue vessels manifested as cold hands and feet, blood stasis, unsmooth blood circulation and soft tendons and vessels, it is combined with Fu Zi to warm kidney and strengthen yang, and gan Jiang and gan Cao to warm the interior, harmonize the middle and dredge the meridian. Achyranthis radix can be added for nourishing liver and kidney, and promoting blood circulation.

Double-2017-11-07 for double-diagnosis

The following symptoms are marked: the weakness of the two lower limbs is obvious, the walking can be about 100 meters, although the pain occurs, the walking can be tolerated and continued compared with the prior walking, the waist is sour, the mouth is dry and bitter, the cold is intolerant, the sweat is easy to appear, the palm is wet and cold, the taking is easy, the sleep is difficult, the excrement is easy to go for 1 to 2 days, the formation is sticky, and the urine is less. Dark red tongue with little coating and deep pulse.

Prescription:

Adding medicine: dried ginger 9g, honey-fried licorice root 10g, dendrobium stem 12g

Square solution: patients take the prescription twice, during which other medicines are not taken, the lower limb weakness is obviously improved, the walking distance is obviously increased, the pain degree is relieved earlier, the patients can continue to walk, and the cold and cool symptoms such as chilly and cold are still existed; according to the tongue pulse, dark tongue and deep pulse, rhizoma Zingiberis and radix Glycyrrhizae Preparata are added; but also dry mouth and bitter taste, Shi Hu can nourish yin and promote the production of body fluid. Discomfort and follow-up diagnosis.

3. Three-king XX female right lower limb arterial occlusion initial diagnosis 2017/6/20 for 61 years old

The main complaints are: pain in the right lower limb for more than 4 years.

The current medical history: pain of the right lower limb occurs when walking 4 years ago, lower limb angiography is performed in three hospitals in northern medicine, the common femoral artery of the right lower limb is found to be blocked, 2 stents are implanted, and postoperative symptoms are relieved. In 2014, 2 stents were implanted again in 2015 due to dilatation in occlusion, in 2016, dilatation in 2016, and occlusion of the right lower extremity artery was reviewed in 2017, and left occlusion was 80%.

The following symptoms are marked: pain in the right lower limb, aversion to cold, cold limbs, anorexia, nausea, insomnia, scanty urine, defecation for 2 days, dark tongue with yellow and greasy coating, and deep pulse.

And (3) Western diagnosis: arterial occlusion of lower limbs and hyperlipidemia

Dialectical traditional Chinese medicine: congealing cold and blood stasis

Prescription:

Adding medicine: scorpio 9g, rhizoma Sparganii 9g, and Curcumae rhizoma 9g

Square solution: the patients have severe arterial occlusion of the lower limbs, involve multiple blood vessels, and have limited nourishment of the limbs, so they are marked by pain, aversion to cold, and coldness of the limbs. According to the tongue pulse, the pain and aversion to cold of the lower limbs, cold limbs, dark tongue and deep pulse of the patients are the manifestations of congealing cold and blood stasis and vessel obstruction, so the blood-breaking and qi-moving herbs such as san Leng, E Zhu and quan Xie are used to strengthen the effect of removing blood stasis and dredging meridians.

Re-diagnosis one 2017/8/22

The following symptoms are marked: the pain, the swelling and the hair sinking of the right lower limb are obviously relieved before the patient takes the medicine, the color of the right lower limb is obviously lighter than that of the right lower limb before the patient takes the medicine, the intolerance of cold is relieved, the patient feels hypodynamia and dizziness, nausea and vomiting are avoided, abdominal distension, hiccup and bitter taste are caused, the patient can take the medicine, sleep is light, defecate is performed in a daily period, and the patient is shaped, sticky in nature and has little urine. Dark tongue with thin and greasy coating and deep and tense pulse.

Prescription:

Adding medicine: 10g of longstamen onion bulb, 9g of rhizoma pinellinae praeparata and 15g of largehead atractylodes rhizome

Square solution: after the patient takes the medicine for more than one month, the pain of the limbs of the patient is obviously relieved, the skin color is obviously improved compared with the prior art, and the original prescription is effective; according to the tongue pulse, patients with dizziness, nausea, sticky stool and thin and greasy tongue coating, which are manifestations of phlegm-dampness, are assisted with the combination of longstamen onion bulb, pinellia tuber and white atractylodes rhizome to help resolve phlegm and eliminate dampness.

Second diagnostic method 2017/9/12

The following symptoms are marked: the pain of the right lower limb is almost absent, the weakness and heaviness of the lower limb are obviously relieved, nausea and vomiting are still absent, dizziness and headache are absent, the patient can take the medicine, sleep is easy, the defecation is performed 1 day, the patient is unformed, the patient is sticky, and the urine volume is small.

Prescription:

Square solution: according to the tongue pulse, the pain of the limbs of the patient basically disappears, the original prescription is effective without complaints, so 2017/8/22 days are continued to be used. Discomfort and follow-up diagnosis.

4. Four Min cases XX female 65 years old right lower limb arterial occlusion preliminary diagnosis 2017/8/8

The main complaints are: the debilitation of both lower limbs is 2 years, and the aggravation is accompanied with pain for 1 year.

The following symptoms are marked: the double lower limbs are lack of strength and pain, cold and numb, the right side is very strong, the skin color is normal, the chest is not stuffy, the chest pain is caused, the breath is short, the strength is low, the aversion to cold is not caused, the sweat is easy to appear, the mouth is dry and the mouth is bitter, the sleep can be received, the stool is possible, and the urine is yellow. A pale tongue with thin coating and a wiry and tense pulse.

Auxiliary inspection: double lower limb blood flow graph (2016-10-26 Boai Hospital): right limb minor arterial occlusive insufficiency; the deep veins and iliac veins of both lower limbs are unobstructed.

History of the past: coronary heart disease 10 years, in 2007, 3 stents were placed in Xuanwu hospital due to myocardial infarction; reducing the number of the first year by more than 5 years; one-sided renal atrophy was found at PIC in 2007; stenosis of the carotid artery; denying the DM; hyperuricemia, liver dysfunction.

And (3) Western diagnosis: hyperuricemia after lower limb arterial occlusion coronary artery stent implantation is distinguished by the traditional Chinese medicine: congealing cold and blood stasis

Prescription:

Adding medicine: scorpio 9g, rhizoma Sparganii 9g, and Curcumae rhizoma 9g

Square solution: the auxiliary examination indicates that patients have limb artery occlusive blood supply deficiency, and have difficulty in nourishing, lower limb debilitation and blood stasis stagnation obstruction caused pain, which is caused by blood stasis and qi stagnation vessel stasis obstruction, so the common burreed rhizome, the zedoary and the scorpion are used for assisting in breaking blood, promoting qi circulation and removing blood stasis.

Re-diagnosis one 2017/9/5

The following symptoms are marked: pain of both lower limbs is almost not seen at night, but walking is unfavorable in daytime, pain and numbness are relieved, weakness is slightly reduced, excessive sweating is caused, particularly, the upper half of the body is severe, even mouth is dry, even chest distress is caused, people like to have a good appetite, sleep can be induced, excrement is 1-2 times daily, the body is thin, urine is frequent at night, 3-4 times per night, the tongue is light, the tongue is thin and greasy, and the pulse is string and tight.

Prescription:

Adding medicine: scorpio 9g, rhizoma Sparganii 9g, and Curcumae rhizoma 9g

Square solution: after the patient takes the medicine above the medicine, the pain of the lower limbs of the patient is reduced in daytime at night, and the patient still has the discomfort of numbness, hypodynamia and the like. For severe blood stasis, the original prescription is supplemented with Scorpio, rhizoma Sparganii, and Curcumae rhizoma for promoting blood circulation and nourishing limbs.

5. Case five xu XX male 69 years old bilateral arteriosclerosis plaque initial diagnosis 2017/8/8

The main complaints are: pain in both lower limbs for 3 years.

The current medical history: the patient has no obvious inducement before 3 years, the patient feels pain on the two lower limbs, the patient affects walking, the patient needs to rest when walking for 100 meters, the feeling of swelling on the two lower limbs is avoided, the skin color is not changed, and the patient can walk in Beijing hospital in 6 months in 2017 by performing artery enhancement CT on the two lower limbs: bilateral arterial plaque stenoses, severe on the right, refusing stent implantation treatment.

The following symptoms are marked: pain in both lower limbs, aggravation after activity, numbness in the right hand, like ant walking, rest relief, pain in the left knee joint, soreness of the waist, no chest distress and chest pain, difficulty in sleeping, and convenient adjustment. Dark tongue with thin and greasy coating and wiry and tense pulse.

History of the past: hypertension is denied for 7 years, and the history of coronary heart disease, diabetes, hyperlipidemia, etc. is denied. And (3) Western diagnosis: lower extremity arterial occlusion, hyperuricemia after coronary stent implantation

Dialectical traditional Chinese medicine: congealing cold and blood stasis

Prescription:

Adding medicine: scorpio 9g, rhizoma Sparganii 9g, and Curcumae rhizoma 9g

Square solution: the arteries of the lower limbs of the patient are occluded for years, the vessels are stagnated and serious, and the muscles, bones and muscles of the patient are not nourished for a long time, so that the patients have abnormal feelings of pain, numbness, ant movement and the like. For removing blood stasis, san Leng, E Zhu and quan Xie are used to assist blood and qi.

Re-diagnosis one 2017/11/28

The following symptoms are marked: the pain of the lower limbs is obviously relieved earlier, the walking distance is increased by about 300 meters, the numb feeling of the right hand is relieved, the left knee joint still has pain, the waist is aching and painful, the chest is not stuffy and painful, the patient can take the medicine, the sleep is difficult, and the patient can feel convenient for the patient. Dark tongue with thin and greasy coating and wiry and tense pulse.

Prescription:

Adding medicine: scorpio 9g, rhizoma Sparganii 9g, and Curcumae rhizoma 9g

Square solution: the walking distance of the patient is obviously increased compared with the prior art, the symptoms of pain, numbness and the like are improved, the patient does not complain of discomfort, and the traditional prescription is effective. Therefore, 2017/8/8 days are reserved. Discomfort and follow-up diagnosis.

Detailed Description

It should be understood that the examples are only for illustrating the present invention and are not intended to limit the scope of the present invention. Simple modifications of the invention using the inventive concept are within the scope of the invention as claimed. In practice, the following examples can achieve the desired effects of the present invention.

Implementation 1: 30g of prepared monkshood, 40g of astragalus, 30g of cassia twig, 10g of white paeony root, 12g of peach seed, 12g of safflower, 3g of leech, 12g of immature bitter orange, 12g of rhubarb and 3g of asarum are taken by decocting with water according to the traditional process, one dose is taken every day, and 15 days are a course of treatment.

Example 2: taking 10g of prepared monkshood, 15g of astragalus root, 9g of cassia twig, 5g of white paeony root, 6g of peach seed, 6g of safflower, 1g of leech, 6g of immature bitter orange, 6g of rhubarb and 1g of asarum, and decocting the raw materials with water according to the traditional process, wherein one dose is taken every day, and 15 days are a course of treatment. .

Example 3: 30g of prepared monkshood, 30g of astragalus, 30g of cassia twig, 10g of white paeony root, 10g of peach kernel, 10g of safflower, 2g of leech, 10g of immature bitter orange, 10g of rhubarb and 2g of asarum are taken by decocting with water according to the traditional process, one dose is taken every day, and 15 days are a course of treatment. .

Example 4: taking 20kg of prepared monkshood, 20kg of astragalus root, 9kg of cassia twig, 8kg of white paeony root, 8-10kg of peach seed, 8kg of safflower, 2kg of leech, 8kg of immature bitter orange, 8kg of rhubarb and 2kg of asarum, adding 10 times of water for decocting for 3 times for the first time, adding 6 times of water for decocting for 1 hour for the second time, combining the filtrates, concentrating under reduced pressure to paste, adding conventional auxiliary materials and preparing into granules.

Example 5: 30kg of prepared aconite, 35kg of astragalus, 20kg of cassia twig, 10kg of white paeony root, 10kg of peach kernel, 10kg of safflower, 3kg of leech, 10kg of immature bitter orange, 10kg of rhubarb and 3kg of asarum are taken, water is added for 2 times, 8 times of water is added for each time for decoction for 1 hour, the filtrates are merged, the filtrate is decompressed and concentrated into paste, and conventional auxiliary materials are added for preparing tablets.

Example 6: 30kg of prepared monkshood, 20kg of astragalus, 20kg of cassia twig, 10kg of white paeony root, 10kg of peach kernel, 10kg of safflower, 2kg of leech, 10kg of immature bitter orange, 8kg of rhubarb and 3kg of asarum are taken, water is added for 2 times, 10 times of water is added for the first time for 1.5 hours, 8 times of water is added for the second time for 1 hour, the filtrates are combined, the mixture is decompressed and concentrated into paste, and conventional auxiliary materials are added for preparing the capsule.

Claims

1. A traditional Chinese medicine composition for treating lower limb arteriosclerosis obliterans is characterized in that the effective components of the traditional Chinese medicine composition are prepared from the following raw material medicines in parts by weight: 10-30 parts of prepared monkshood, 15-40 parts of astragalus, 9-30 parts of cassia twig, 5-10 parts of white paeony root, 6-12 parts of peach kernel, 6-12 parts of safflower, 1-3 parts of leech, 6-12 parts of immature bitter orange, 6-12 parts of rhubarb and 1-3 parts of asarum.

2. The traditional Chinese medicine composition according to claim 1, which is characterized in that the mixture ratio of the raw materials is as follows: 20-30 parts of prepared monkshood, 20-35 parts of astragalus membranaceus, 9-20 parts of cassia twig, 8-10 parts of radix paeoniae alba, 8-10 parts of peach kernel, 8-10 parts of safflower, 2-3 parts of leech, 8-10 parts of immature bitter orange, 8-10 parts of rheum officinale and 2-3 parts of asarum.

3. The traditional Chinese medicine composition according to claim 2, which is characterized in that the mixture ratio of the raw materials is as follows: 30 parts of prepared monkshood, 30 parts of astragalus, 9 parts of cassia twig, 10 parts of white paeony root, 9 parts of peach seed, 9 parts of safflower, 3 parts of leech, 9 parts of immature bitter orange, 9 parts of rhubarb and 3 parts of asarum.

4. The traditional Chinese medicine composition according to any one of claims 1 to 3, characterized in that the following drugs are added to the raw material drugs: 8-10 parts of scorpion, 8-10 parts of rhizoma sparganii and 8-10 parts of curcuma zedoary.

5. The traditional Chinese medicine composition according to claim 4, wherein the weight ratio of the scorpion, the rhizoma sparganii and the curcuma zedoary is 9: 9: 9.

6. use of a Chinese medicinal composition according to any one of claims 1 to 5 in the manufacture of a medicament for the treatment of lower limb arteriosclerotic occlusive disease.