CN109907064A - A kind of Tebuconazole Prochloraz suspending agent and its preparation method and application - Google Patents
A kind of Tebuconazole Prochloraz suspending agent and its preparation method and application Download PDFInfo
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- CN109907064A CN109907064A CN201910284519.XA CN201910284519A CN109907064A CN 109907064 A CN109907064 A CN 109907064A CN 201910284519 A CN201910284519 A CN 201910284519A CN 109907064 A CN109907064 A CN 109907064A
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- tebuconazole
- prochloraz
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Abstract
The present invention provides a kind of Tebuconazole Prochloraz suspending agents and its preparation method and application.Tebuconazole Prochloraz suspending agent of the present invention is mainly prepared from the following raw materials: Tebuconazole, Prochloraz, thickener, defoaming agent, dispersing agent, wetting agent, suspending agent, antifreezing agent, anti hardening agent and filler.In the present invention, by the way that Tebuconazole and Prochloraz to be used in compounding, good fiting effect can be played, for single formulation, compound preparation is higher for the inhibitory activity of the plant pests such as wheat scab, and drug effect is more preferable.
Description
Technical field
The present invention relates to pesticide fields, in particular to a kind of Tebuconazole Prochloraz suspending agent and preparation method thereof
And application.
Background technique
Tebuconazole (Tebuconazole) is a kind of efficient, wide spectrum, absorbability triazole type sterilization pesticide, has higher
Bactericidal activity and good long-term effect, be mainly used for prevent and treat wheat, rice, peanut, vegetables, banana, apple, corn, height
Fungal disease on the crops such as fine strain of millet.
Prochloraz (Prochloraz) is a kind of imidazoles fungicide, and also a kind of wide-spectrum bactericide, can be used for
Cereal crop stem, leaf, many diseases, such as powdery mildew, leaf spot on fringe etc. are prevented and treated, equally can be used for fruit tree, vegetable
The inhibition and killing of many pathogens of dish and ornamental plant.
Although Tebuconazole and Prochloraz single dose or the pesticide bactericide compounded with other are widely used.However,
Both bactericide compounded researchs used are actually rare, and correlative study or report without the two compounding suspending agent
Road.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of Tebuconazole Prochloraz suspending agent, Tebuconazole Prochloraz of the present invention
Suspending agent has good plant pest management effect, while also filling up the research blank of related fields.
The second object of the present invention is to provide the preparation method of Tebuconazole Prochloraz suspending agent described in one kind,.
Third of the present invention is designed to provide the application of Tebuconazole Prochloraz suspending agent described in one kind.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
A kind of Tebuconazole Prochloraz suspending agent, the Tebuconazole Prochloraz suspending agent are mainly prepared from the following raw materials:
Tebuconazole, Prochloraz, thickener, defoaming agent, dispersing agent, wetting agent, suspending agent, antifreezing agent, anti hardening agent, and
Filler.
Meanwhile the present invention also provides the preparation methods of the Tebuconazole Prochloraz suspending agent, comprising: will defoam
After agent, dispersing agent, wetting agent, suspending agent, antifreezing agent, anti hardening agent, filler mix dispersion with Tebuconazole and Prochloraz, it is added
The shearing of thickener homogeneous, obtains Tebuconazole Prochloraz suspending agent after filtering.
Further, present invention provides Tebuconazole Prochloraz suspending agent the answering in plant pest
With.
Likewise, the present invention also provides pesticides or composition pesticide comprising Tebuconazole Prochloraz suspending agent.
Compared with prior art, the invention has the benefit that
(1) in the present invention, by the way that Tebuconazole and Prochloraz to be used in compounding, good fiting effect can be played, is compared
For single formulation, compound preparation is higher for the inhibitory activity of the plant pests such as wheat scab, and drug effect is more preferable.
(2) single medicament use is easy to produce drug resistance, and two kinds of fungicide of Tebuconazole and Prochloraz are used in combination, can
Delay the generation of single dose drug resistance.
(3) Original Tebuconazole price is higher, and Prochloraz raw medicine price is relatively low, and the two, which is used in combination, to be reduced
Use cost reduces peasant household's burden, improves the economic and social benefits.
(4) since there is synergistic effect after Tebuconazole and Prochloraz compounding, it is thus possible to reduce Pesticide use amount, and then subtract
Few applications of pesticide caused by environment for polluting.
(5) for compared to traditional solution, suspending agent provided by the present invention is using water as filler, thus stability
Height, application effect are good, and safer environmental protection, while also avoiding inflammable and harmful etc. caused by organic solvent use
Problem.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
In view of Tebuconazole and Prochloraz single dose existing shortcoming in practical applications, the present invention provides one
Kind is using Tebuconazole and Prochloraz as the suspending agent of functional materials, to solve defect present in existing single dose.
Specifically, Tebuconazole Prochloraz suspending agent of the present invention is prepared from the following raw materials: Tebuconazole, Prochloraz, thickener,
Defoaming agent, dispersing agent, wetting agent, suspending agent, antifreezing agent, anti hardening agent and filler；
In a currently preferred scheme, the thickener be xanthan gum, xanthan gum be at present in the world collection thickening,
It suspends, emulsify, being stable at the biogum that integrated best performance is got over.
In a currently preferred scheme, the defoaming agent is organosilicon, its main component of organic silicon defoamer is
Silicone oil organosilicon is nonvolatile oily liquids, insoluble in water, vegetable and animals oils and mineral oil or solubility under silicone oil room temperature
Very little, can high temperature resistant, also low-temperature-resistant.Chemical property inertia, physical performance are stablized, inactive.
Organic silicon defoamer is a kind of lotion of thick white.Each industrial circle is just used for from the sixties, but extensive
It is since the eighties with comprehensive fast development.As organic silicon defoamer, application field is also very extensive, increasingly
Attention by all trades and professions.It is that indispensable one kind helps in production process in the industrial departments organic silicon defoamer such as pesticide
Agent, it can not only remove the foam on production process technology medium liquid level, so as to improve the techniques mistake such as being filtered, washed, extracting
The separation of journey, drain and other effects.
In a currently preferred scheme, the dispersing agent is polycarboxylate, can have significant guarantor for this preparation
The stability for holding product extends the quality guarantee period of product.
In a currently preferred scheme, the wetting agent is fatty alcohol polyoxyethylene ether.
In a currently preferred scheme, the suspending agent is aluminum magnesium silicate.
In a currently preferred scheme, the antifreezing agent is propylene glycol.
In a currently preferred scheme, the anti hardening agent is white carbon black.
In a currently preferred scheme, the filler is deionized water.
Further, in Tebuconazole Prochloraz suspending agent of the present invention, Tebuconazole and Prochloraz mass percent accounting it
Be 10~90%, such as can be, but be not limited to 15,20,30,35,40,45,50,60,70,80 or 85% etc.；
Preferably, in suspending agent provided by the present invention, the sum of Tebuconazole and Prochloraz mass percent accounting be 30~
70%；
It is furthermore preferred that the sum of Tebuconazole and Prochloraz mass percent accounting are 45 in suspending agent provided by the present invention
~50%；
Particularly, Tebuconazole Prochloraz suspending agent provided by the present invention is 45% Tebuconazole Prochloraz suspending agent
(i.e. in suspending agent, 45%) the sum of Tebuconazole and Prochloraz mass percent accounting are.
Meanwhile in Tebuconazole Prochloraz suspending agent of the present invention, the mass ratio of Tebuconazole and Prochloraz be preferably 1:10~
10:1, such as can be, but be not limited to 1:2,1:3,1:5,1:7,9:1,1:10,2:1,3:1,5:1,7:1,9:1 or 10:1
Deng；
Preferably, in Tebuconazole Prochloraz suspending agent of the present invention, the mass ratio of Tebuconazole and Prochloraz is 1:2~2:1；
It is furthermore preferred that the mass ratio of Tebuconazole and Prochloraz is 1:1~1 in Tebuconazole Prochloraz suspending agent of the present invention:
2；
Particularly, in Tebuconazole Prochloraz suspending agent of the present invention, the mass ratio of Tebuconazole and Prochloraz is 1:2.
Particularly preferred, Tebuconazole Prochloraz suspending agent provided by the present invention is the suspension of 45% Tebuconazole Prochloraz
Agent, and the mass ratio of Tebuconazole and Prochloraz is 1:2.
Above-mentioned Tebuconazole Prochloraz suspending agent drug effect provided by the present invention is high, environmental-friendly, highly-safe, it is specific and
Speech, (1) suspending agent is without dust harzard, to operator and Environmental security；(2) suspending agent is using water as decentralized medium, not by having
The inflammable and drug injury problem that solvent generates；(3) in contrast with wettable powder, the preparation of suspending agent allows to select different grains
The raw medicine of diameter, to make biological effect and the physical stability of preparation reach best；(4) liquid suspension is spread good in water
It is good, spray liquid use can be directly prepared into；(5) ratio of suspending agent is great, and packaging volume is small；(6) suspending agent dispersibility and open up
Property it is all relatively good, suspensibility is high, and the ability for being adhered to plant surface is stronger, resistance of rainwater washing against, thus drug effect is compared with wettable
Pulvis is significant and also relatively more lasting；(7) suspending agent have particle is small, active surface is big, penetration is strong, when making up a prescription without dust, at
The features such as this is low, drug effect is high.And the advantages of having wettable powder and missible oil concurrently, it can be readily wetted by water, it is good to be diluted with water rear suspension.
In the present invention, by the selection and adjustment for each auxiliary material, thus a kind of suitable and Tebuconazole, Prochloraz are also provided
The aqueous pesticide system that function raw material is used cooperatively equally also provides a kind of safer, environmentally friendly and effective Novel rural
Medicine.
Meanwhile the present invention is also corresponding provides the preparation method of the Tebuconazole Prochloraz suspending agent, including as follows
Step:
According to dosage, each raw material is accurately weighed respectively；
Then, by defoaming agent, dispersing agent, wetting agent, suspending agent, antifreezing agent, anti hardening agent, filler and Tebuconazole and miaow
It is pre-dispersed after fresh amine mixing, grinding distribution is then carried out using multistage be sanded；
The shearing of thickener homogeneous is added, Tebuconazole Prochloraz suspending agent is obtained after filtering.
Wherein, in method produced above, each raw material dosage is as follows:
Tebuconazole 10~25%, such as can be, but be not limited to 15% 20% etc.；Prochloraz 20~35%, such as can be with
For, but it is not limited to 25%, 30% etc.；Thickener 0.1~1%, such as can be, but be not limited to 0.3% 0.5%, 0.7% etc.；
Defoaming agent 0.5~1.5%, such as can be, but be not limited to 0.8% 1%, 1.2% etc.；Dispersing agent 5~10%, such as can be with
For, but it is not limited to 6%, 8% etc.；Wetting agent 1~5%, such as can be, but be not limited to 2% 3% etc.；Suspending agent 3~8%,
It such as can be, but be not limited to 4% 5% etc.；Antifreezing agent 5~12%, such as can be, but be not limited to 6% 8%, 10% etc.；
Anti hardening agent 1~5%, such as can be, but be not limited to 2% 3% etc.；And filler 20~40%, such as can be, but
It is not limited to 25%, 30% or 35% etc.；
Condition is that the sum of each raw material dosage is 100%.
Preferably, in method produced above, each raw material dosage is as follows:
Tebuconazole 15%, Prochloraz 30%, thickener 0.3%, defoaming agent 0.8%, dispersing agent 8%, wetting agent 3% help
Suspension 4%, antifreezing agent 6%, the filler of anti hardening agent 2% and surplus；
Condition is that the sum of each raw material dosage is 100%.
For plant pest, (especially fungi causes to plant the Tebuconazole Prochloraz suspending agent as prepared by method as above
Object disease) there is good preventive and therapeutic effect, there is excellent control efficiency especially for wheat scab.
Therefore, Tebuconazole Prochloraz suspending agent of the present invention can also be further used for the prevention and control of plant diseases, pest control of corresponding plants
In, and in practical applications, Tebuconazole Prochloraz suspending agent of the present invention can be used alone, it can also be by itself and other agricultures
Medicine is used cooperatively, to achieve the purpose that integrated control effect.
Embodiment 1
According to mass percent:
Tebuconazole 15%, Prochloraz 30%, xanthan gum 0.3%, organosilicon 0.8%, polycarboxylate salt dispersant 8%, fat
Alcohol polyoxyethylene ether 3%, aluminum magnesium silicate 4%, propylene glycol 6%, the deionized water of white carbon black 2% and surplus weigh appropriate each
Raw material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 45% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 2
According to mass percent:
Tebuconazole 30%, Prochloraz 15%, xanthan gum 0.8%, organosilicon 1.2%, polycarboxylate salt dispersant 10%, fat
Alcohol polyoxyethylene ether 1%, aluminum magnesium silicate 5%, propylene glycol 5%, the deionized water of white carbon black 3% and surplus weigh appropriate each
Raw material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 45% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 3
According to mass percent:
Tebuconazole 22.5%, Prochloraz 22.5%, xanthan gum 0.3%, organosilicon 0.8%, polycarboxylate salt dispersant 5%,
Fatty alcohol polyoxyethylene ether 3%, aluminum magnesium silicate 8%, propylene glycol 10%, the deionized water of white carbon black 1% and surplus weigh
Appropriate each raw material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 45% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 4
According to mass percent:
Tebuconazole 20%, Prochloraz 55%, xanthan gum 0.3%, organosilicon 0.8%, polycarboxylate salt dispersant 5%, fat
Alcohol polyoxyethylene ether 3%, aluminum magnesium silicate 8%, propylene glycol 10%, the deionized water of white carbon black 1% and surplus weigh appropriate
Each raw material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 75% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 5
According to mass percent:
Tebuconazole 15%, Prochloraz 50%, xanthan gum 1%, organosilicon 1.5%, polycarboxylate salt dispersant 5%, fatty alcohol
Polyoxyethylene ether 1%, aluminum magnesium silicate 3%, propylene glycol 8%, the deionized water of white carbon black 1% and surplus weigh appropriate each original
Material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 65% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 6
According to mass percent:
Tebuconazole 14%, Prochloraz 36%, xanthan gum 0.2%, organosilicon 0.6%, polycarboxylate salt dispersant 9%, fat
Alcohol polyoxyethylene ether 5%, aluminum magnesium silicate 8%, propylene glycol 8%, the deionized water of white carbon black 3% and surplus weigh appropriate each
Raw material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 50% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 7
According to mass percent:
Tebuconazole 10%, Prochloraz 30%, xanthan gum 0.2%, organosilicon 0.6%, polycarboxylate salt dispersant 9%, fat
Alcohol polyoxyethylene ether 5%, aluminum magnesium silicate 8%, propylene glycol 8%, the deionized water of white carbon black 3% and surplus weigh appropriate each
Raw material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 40% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 8
According to mass percent:
Tebuconazole 10%, Prochloraz 20%, xanthan gum 0.2%, organosilicon 0.6%, polycarboxylate salt dispersant 9%, fat
Alcohol polyoxyethylene ether 5%, aluminum magnesium silicate 8%, propylene glycol 8%, the deionized water of white carbon black 3% and surplus weigh appropriate each
Raw material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 30% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 9
According to mass percent:
Tebuconazole 5%, Prochloraz 10%, xanthan gum 0.2%, organosilicon 0.6%, polycarboxylate salt dispersant 9%, fatty alcohol
Polyoxyethylene ether 5%, aluminum magnesium silicate 8%, propylene glycol 8%, the deionized water of white carbon black 3% and surplus weigh appropriate each original
Material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 15% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 10
According to mass percent:
Tebuconazole 4%, Prochloraz 8%, xanthan gum 0.2%, organosilicon 0.6%, polycarboxylate salt dispersant 9%, fatty alcohol
Polyoxyethylene ether 5%, aluminum magnesium silicate 8%, propylene glycol 8%, the deionized water of white carbon black 3% and surplus weigh appropriate each original
Material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 12% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 11
According to mass percent:
Tebuconazole 25%, Prochloraz 60%, xanthan gum 1%, organosilicon 1.5%, polycarboxylate salt dispersant 2%, fatty alcohol
Polyoxyethylene ether 1%, aluminum magnesium silicate 3%, propylene glycol 3%, the deionized water of white carbon black 1% and surplus weigh appropriate each original
Material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 85% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 12
According to mass percent:
Tebuconazole 30%, Prochloraz 40%, xanthan gum 1%, organosilicon 1.5%, polycarboxylate salt dispersant 2%, fatty alcohol
Polyoxyethylene ether 1%, aluminum magnesium silicate 3%, propylene glycol 3%, the deionized water of white carbon black 1% and surplus weigh appropriate each original
Material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 70% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 13
According to mass percent:
Tebuconazole 25%, Prochloraz 30%, xanthan gum 1%, organosilicon 1.5%, polycarboxylate salt dispersant 2%, fatty alcohol
Polyoxyethylene ether 1%, aluminum magnesium silicate 3%, propylene glycol 3%, the deionized water of white carbon black 1% and surplus weigh appropriate each original
Material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 55% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 14
According to mass percent:
Tebuconazole 5%, Prochloraz 15%, xanthan gum 1%, organosilicon 1.5%, polycarboxylate salt dispersant 5%, poly alkyl alcohol
Ethylene oxide ether 3%, aluminum magnesium silicate 3%, propylene glycol 10%, the deionized water of white carbon black 1% and surplus weigh appropriate each original
Material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 20% Tebuconazole Prochloraz suspending agent is obtained after filtering.
Embodiment 15
According to mass percent:
Tebuconazole 7%, Prochloraz 8%, xanthan gum 1%, organosilicon 1.5%, polycarboxylate salt dispersant 2%, poly alkyl alcohol
Ethylene oxide ether 1%, aluminum magnesium silicate 3%, propylene glycol 3%, the deionized water of white carbon black 1% and surplus weigh appropriate each original
Material.
By organosilicon, polycarboxylate, fatty alcohol polyoxyethylene ether, aluminum magnesium silicate, propylene glycol, white carbon black, deionized water with
It is pre-dispersed after Tebuconazole and Prochloraz mixing, grinding distribution is then carried out using multistage be sanded；Then, xanthan gum homogeneous is added to cut
It cuts, 15% Tebuconazole Prochloraz suspending agent is obtained after filtering.
1 Tebuconazole of experimental example-Prochloraz recipe determination experiment
Tebuconazole Prochloraz compounding agent is to the active interaction effect of fusarium graminearum
Inhibit mycelia growth percentage and virulence regression equation according to each medicament single dose and compounding agent, each compounded combination it is mutual
It is as follows to make effect calculating:
(i) Tebuconazole Prochloraz (4:1)
From test (i) and (ii) Tebuconazole and Prochloraz single dose are tested to the EC of fusarium graminearum50Value is respectively
0.0995 μ g/ml and 0.24 μ g/ml, the theoretical EC according to the virulence of two kinds of medicaments, after 4:1 compounding50Value is answered are as follows:
EC50(theoretical value)=1/ [(4/5)/0.0995+ (1/5)/0.024]=0.0611 μ g/ml；
SR50=EC50(theoretical value)/EC50(observed value)=0.0611/0.0529=1.16.
(ii) Tebuconazole Prochloraz (2:1)
EC50(theoretical value)=1/ [(2/3)/0.0995+ (1/3)/0.024]=0.0486 μ g/ml；
SR50=EC50(theoretical value)/EC50(observed value)=0.0486/0.0484=1.00.
(iii) Tebuconazole Prochloraz (1:1)
EC50(theoretical value)=1/ [(1/2)/0.0995+ (1/2)/0.024]=0.0387 μ g/ml；
SR50=EC50(theoretical value)/EC50(observed value)=0.0387/0.0345=1.12.
(iv) Tebuconazole Prochloraz (1:2)
EC50(theoretical value)=1/ [(1/3)/0.0995+ (2/3)/0.024]=0.0321 μ g/ml；
SR50=EC50(theoretical value)/EC50(observed value)=0.0321/0.0274=1.17.
(v) Tebuconazole Prochloraz (1:4)
EC50(theoretical value)=1/ [(1/5)/0.0995+ (4/5)/0.024]=0.0283 μ g/ml；
SR50=EC50(theoretical value)/EC50(observed value)=0.0283/0.0263=1.08.
Experimental result as above is summarized as follows shown in table:
| Medicament | EC50μg/ml | SR50 |
| Tebuconazole | 0.0995 | / |
| Prochloraz | 0.024 | / |
| Tebuconazole: Prochloraz=4:1 | 0.0529 | 1.16 |
| Tebuconazole: Prochloraz=2:1 | 0.0484 | 1.00 |
| Tebuconazole: Prochloraz=1:1 | 0.0345 | 1.12 |
| Tebuconazole: Prochloraz=1:2 | 0.0274 | 1.17 |
| Tebuconazole: Prochloraz=1:4 | 0.0263 | 1.08 |
By result data as above it is found that after Tebuconazole Prochloraz compounded according to each ratio, main performance adduction is made
With no antagonism.Comprehensive analysis is it is found that according to Tebuconazole: Prochloraz=1:2 ratio can obtain preferable compounding and suppression
Bacterium effect.
2 45% Tebuconazole of experimental example-Prochloraz suspending agent detection and effect experiment
(1) toxicity
Respectively to commercially available Original Tebuconazole, Prochloraz raw medicine and 1 suspending agent of embodiment are determinand, carry out toxicity survey
Examination, as a result as follows:
Tebuconazole: rat acute toxicity LD50For 4000mg/kg (hero), 1700mg/kg (female)；Rat acute is percutaneous
Toxicity LD50 > 5000mg/kg；Rat acute toxicity on inhalation LC50For 5.1mg/L.
Prochloraz: rat acute toxicity LD50For 1023mg/kg；Rat acute percutaneous toxicity LD50>2100mg/kg；
Rat acute toxicity on inhalation LC50>2.16mg/L。
Rat acute toxicity LD50>2000mg/kg；Rat acute percutaneous toxicity LD50>2000mg/kg；Rat acute
Toxicity on inhalation LC50>5000mg/m3。
By testing result as above it is found that according to Pesticidal products toxicity grading standard, 45% Tebuconazole Prochloraz of the invention
Suspending agent belongs to less toxic rank.
(2) pharmacodynamic test
Four ground field control effectiveness test results are as shown in the table within 2 years:
By test result as above it is found that 45% Tebuconazole Prochloraz suspending agent of the invention is prevented and treated wheat scab and imitated
Fruit is preferable.
(3) results from residue tests
Test site: Heilongjiang Province's Hailun City, Jinan City, Shandong Province, Inner Mongolia Autonomous Region Chifeng City Wengniute Banner
Wheat (Heilungkiang kind Wheat-wheatgrass No.33 number, Shandong kind Shandong wheat 22 and Jimai 22, the small ice of Inner Mongolia Autonomous Region kind
Wheat No. 33).
If two application dosage: low dosage and high dose.Low dosage is amount of formulation 466.5g/ha (210ga.i./ha), high
Dosage is amount of formulation 700g/ha (315g a.i./ha) application.2 times, 3 applications, two processing are respectively set, each processing sets 3 weights
It is multiple, plot area 30m2, start the 1st application in wheat flowering initial stage and full-bloom stage, be administered interval 7d.Collecting time distance
The interval time of last time application is 14d.Clear water blank control separately is set, sets protection band between processing.
The acquisition of plant and wheat sample: take in experimental plot at random at 5 points, every 1m2, acquire wheat overground part plant
And the wheat head, plant are cut into 1cm segment, quartering keeps sample 200g after mixing；Wheat kernel is taken off, quartering keeps sample 1kg after mixing,
It is fitted into the polybag with sealing, glues label, be stored in -20 DEG C of refrigerator-freezers and save.Away from not sampled in cell edge 0.5m.
The experimental results are shown inthe following table:
By experimental result as above it is found that the residual quantity of 45% Tebuconazole-Prochloraz suspending agent of the invention is lower, for ecology
Pressure caused by environment is smaller.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from of the invention
Many other change and modification can be made in the case where spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of Tebuconazole Prochloraz suspending agent, which is characterized in that the Tebuconazole Prochloraz suspending agent is mainly by following
Raw material is made:
Tebuconazole, Prochloraz, thickener, defoaming agent, dispersing agent, wetting agent, suspending agent, antifreezing agent, anti hardening agent, and filling
Agent.
2. Tebuconazole Prochloraz suspending agent according to claim 1, which is characterized in that the Tebuconazole Prochloraz is outstanding
In floating agent, the mass ratio of Tebuconazole and Prochloraz is 1:10~10:1；
Preferably, the mass ratio of Tebuconazole and Prochloraz is 1:2~2:1；
It is furthermore preferred that the mass ratio of Tebuconazole and Prochloraz is 1:1~1:2.
3. Tebuconazole Prochloraz suspending agent according to claim 1, which is characterized in that the Tebuconazole Prochloraz is outstanding
In floating agent, the sum of Tebuconazole and Prochloraz mass percent accounting are 10~90%；
Preferably, the sum of Tebuconazole and Prochloraz mass percent accounting are 30~70%；
It is furthermore preferred that the sum of Tebuconazole and Prochloraz mass percent accounting are 45~50%.
4. Tebuconazole Prochloraz suspending agent according to claim 1, which is characterized in that the thickener includes: xanthan
Glue；
And/or the defoaming agent includes: organosilicon；
And/or the dispersing agent includes: polycarboxylate；
And/or the wetting agent includes: fatty alcohol polyoxyethylene ether；
And/or the suspending agent includes: aluminum magnesium silicate；
And/or the antifreezing agent includes: propylene glycol；
And/or the anti hardening agent includes: white carbon black；
And/or the filler includes: deionized water.
5. Tebuconazole Prochloraz suspending agent described in any one of -4 according to claim 1, which is characterized in that according to quality hundred
Score meter, the Tebuconazole Prochloraz suspending agent are mainly prepared from the following raw materials:
Tebuconazole 10~25%, Prochloraz 20~35%, thickener 0.1~1%, defoaming agent 0.5~1.5%, dispersing agent 5~
10%, wetting agent 1~5%, suspending agent 3~8%, antifreezing agent 5~12%, anti hardening agent 1~5% and filler 20~
40%.
6. the preparation method of Tebuconazole Prochloraz suspending agent of any of claims 1-5, which is characterized in that packet
It includes:
Defoaming agent, dispersing agent, wetting agent, suspending agent, antifreezing agent, anti hardening agent, filler are mixed with Tebuconazole and Prochloraz
After dispersion, the shearing of thickener homogeneous is added, Tebuconazole Prochloraz suspending agent is obtained after filtering.
7. preparation method according to claim 6, which is characterized in that the dispersion includes pre-dispersed and multistage be sanded is divided
It dissipates.
8. application of the Tebuconazole Prochloraz suspending agent of any of claims 1-5 in plant pest.
9. application according to claim 8, which is characterized in that the plant pest includes wheat scab, white wheat
Powder disease, rice sheath blight disease, rice blast and rice green smut.
10. including the pesticide or composition pesticide of Tebuconazole Prochloraz suspending agent of any of claims 1-5.
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Application publication date: 20190621 |