CN109893649A - A pharmaceutical composition for treating gynecological inflammation and preparation method thereof - Google Patents
A pharmaceutical composition for treating gynecological inflammation and preparation method thereof Download PDFInfo
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- CN109893649A CN109893649A CN201711314851.3A CN201711314851A CN109893649A CN 109893649 A CN109893649 A CN 109893649A CN 201711314851 A CN201711314851 A CN 201711314851A CN 109893649 A CN109893649 A CN 109893649A
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 206010061218 Inflammation Diseases 0.000 title abstract description 8
- 230000004054 inflammatory process Effects 0.000 title abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 39
- 210000002969 egg yolk Anatomy 0.000 claims abstract description 32
- 108060003951 Immunoglobulin Proteins 0.000 claims abstract description 31
- 102000018358 immunoglobulin Human genes 0.000 claims abstract description 31
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 24
- 241001646826 Isodon rubescens Species 0.000 claims abstract description 24
- 241000218176 Corydalis Species 0.000 claims abstract description 23
- 240000003705 Senecio vulgaris Species 0.000 claims abstract description 23
- 241000157352 Uncaria Species 0.000 claims abstract description 23
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 22
- 229960000846 camphor Drugs 0.000 claims abstract description 22
- 229930008380 camphor Natural products 0.000 claims abstract description 22
- 239000000284 extract Substances 0.000 claims abstract description 21
- 238000000605 extraction Methods 0.000 claims abstract description 16
- 238000002156 mixing Methods 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims abstract description 5
- 238000001291 vacuum drying Methods 0.000 claims abstract 2
- 239000000427 antigen Substances 0.000 claims description 24
- 102000036639 antigens Human genes 0.000 claims description 24
- 108091007433 antigens Proteins 0.000 claims description 24
- 241001671204 Stemona Species 0.000 claims description 22
- 230000009194 climbing Effects 0.000 claims description 22
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 19
- 241000894006 Bacteria Species 0.000 claims description 19
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 19
- 239000012530 fluid Substances 0.000 claims description 16
- 241000287828 Gallus gallus Species 0.000 claims description 15
- 230000001900 immune effect Effects 0.000 claims description 9
- 241000222122 Candida albicans Species 0.000 claims description 8
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 8
- 241000191967 Staphylococcus aureus Species 0.000 claims description 8
- 241000194017 Streptococcus Species 0.000 claims description 8
- 229940095731 candida albicans Drugs 0.000 claims description 8
- 230000002949 hemolytic effect Effects 0.000 claims description 8
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- 238000001035 drying Methods 0.000 claims description 6
- 241000272201 Columbiformes Species 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 5
- 210000000481 breast Anatomy 0.000 claims description 5
- 230000002779 inactivation Effects 0.000 claims description 5
- 230000003014 reinforcing effect Effects 0.000 claims description 5
- 210000000689 upper leg Anatomy 0.000 claims description 4
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- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 25
- 239000003814 drug Substances 0.000 abstract description 21
- 229940079593 drug Drugs 0.000 abstract description 18
- 239000007788 liquid Substances 0.000 abstract description 10
- 229940037003 alum Drugs 0.000 abstract 2
- 241001146210 Senecio scandens Species 0.000 abstract 1
- -1 dried alum Chemical compound 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 230000010356 wave oscillation Effects 0.000 abstract 1
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- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 8
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- 239000003908 antipruritic agent Substances 0.000 description 7
- 231100000614 poison Toxicity 0.000 description 6
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- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
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- 241000305071 Enterobacterales Species 0.000 description 1
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a pharmaceutical composition for treating gynecological inflammation and a preparation method thereof, and relates to the field of medicines. The pharmaceutical composition comprises: yolk immunoglobulin composition, Rabdosia rubescens, rhizoma corydalis, senecio scandens, camphor, dried alum, acetylsalicylic acid, radix stemonae and uncaria. The preparation method comprises the following steps: mixing Rabdosia rubescens, rhizoma corydalis, groundsel, radix stemonae and uncaria in a material-liquid ratio of 1: 4-6, mixing with water, and extracting by adopting a sound wave oscillation extraction method to obtain a liquid medicine; mixing the liquid medicine with dried alum and camphor, and concentrating to obtain an extract; mixing the extract with yolk immunoglobulin composition and acetylsalicylic acid, and vacuum drying. The pharmaceutical composition has good curative effect on gynecological inflammation, and has the characteristics of quick response, good curative effect and no side effect.
Description
Technical field
The present invention relates to drug field, in particular to a kind of pharmaceutical composition for treating gynaecological imflammation and its
Preparation method.
Background technique
Gynaecological imflammation be primarily referred to as female sex organ by various pathogenic bacteria invasion infection after occur it is acute or slow
Property inflammation, such as vulvitis, vaginitis, cervicitis, hysteritis, pelvic inflammatory disease, adnexitis etc..This kind of gynaecological imflammation as controlled not in time
It treats, mutually being spread in each physiological site in addition to cross-infection except may cause inflammation, many complication such as gynecological tumor can be brought
With it is infertile.
Although it is more for treating the drug of gynaecological imflammation currently on the market, and this similar drug healing period is longer, curative effect is not
It is good, the pain of patient cannot be eliminated in a short time, improves the sense of discomfort of patient, and long-time service can also generate side effect.
Summary of the invention
The first object of the present invention is to provide a kind of for treating the pharmaceutical composition of gynaecological imflammation, the pharmaceutical composition
It to the gynaecological imflammation, such as adnexitis, pelvic inflammatory disease, vaginitis etc. caused by being invaded in wet poison, has a good effect, and has and work
Fastly, curative effect is good, the characteristics of having no toxic side effect.
The second object of the present invention be to provide it is a kind of for treating the preparation method of the pharmaceutical composition of gynaecological imflammation, should
Medicinal material used in preparation method is cheap and easy to get, and preparation method is simple, obtained pharmaceutical composition quality height, good drug efficacy.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
It is a kind of for treating the pharmaceutical composition of gynaecological imflammation, which includes: according to parts by weight
6~12 parts of Yolk immunoglobulin composition, 5~9 parts of Rabdosia rubescens, 2~7 parts of rhizoma corydalis, 2~7 parts of climbing groundsel, camphor tree
5~9 parts of brain, 2~7 parts of alumen, 2~7 parts of acetylsalicylic acid, 2~7 parts of the tuber of stemona, 3~7 parts of uncaria.
It is a kind of for treating the preparation method of the pharmaceutical composition of gynaecological imflammation, comprising:
According to parts by weight, by Rabdosia rubescens, rhizoma corydalis, climbing groundsel, the tuber of stemona and uncaria mix, according to solid-liquid ratio 1:4~6 with
Water mixing, extracts to obtain medical fluid using sound wave shock extraction method；
After medical fluid is mixed with alumen, camphor again, it is concentrated to give medicinal extract；
Medicinal extract is mixed with Yolk immunoglobulin composition, acetylsalicylic acid again, is dried in vacuo.
Compared with prior art, beneficial effects of the present invention for example,
It is provided by the invention this for treating the pharmaceutical composition of gynaecological imflammation, be with Yolk immunoglobulin composition
Active constituent can play good killing effect to various pathogens；Meanwhile the pharmaceutical composition by from it is clearing heat and detoxicating,
Dispel pathogenic wind and remove dampness, desinsection is antipruritic, the aspect of swelling and pain relieving this four connection and medication, reduce the wet poison and wind toxin of patient's body, kill simultaneously
Worm is antipruritic, with removing damp-heat, the sense of discomfort of reduction of patient；It is aided with swelling and pain relieving drug again, to mitigate the pain of patient, improves
Healing ability.By a variety of rational proportions having effects that between above-mentioned drug, the pharmaceutical composition in wet poison to caused by invading
Gynaecological imflammation, such as adnexitis, pelvic inflammatory disease, vaginitis etc., have a good effect, and have that rapid-action, curative effect is good, nontoxic
The characteristics of side effect.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
Present embodiment provides a kind of for treating the pharmaceutical composition of gynaecological imflammation, and the pharmaceutical composition is in parts by weight
Meter includes:
6~12 parts of Yolk immunoglobulin composition, 5~9 parts of Rabdosia rubescens, 2~7 parts of rhizoma corydalis, 2~7 parts of climbing groundsel, camphor tree
5~9 parts of brain, 2~7 parts of alumen, 2~7 parts of acetylsalicylic acid, 2~7 parts of the tuber of stemona, 3~7 parts of uncaria.
According to parts by weight, Yolk immunoglobulin composition is 6~10 parts, Rabdosia rubescens is 6~8 parts, rhizoma corydalis be 3~
5 parts, climbing groundsel be 3~5 parts, camphor is 6~8 parts, alumen is 3~5 parts, acetylsalicylic acid is 3~5, the tuber of stemona is 3~5 parts, hook
Rattan is 4~6 parts.
According to parts by weight, Yolk immunoglobulin composition is 7~9 parts, Rabdosia rubescens is 6~7 parts, rhizoma corydalis is 4~5
Part, climbing groundsel be 4~5 parts, camphor is 6~7 parts, alumen is 4~5 parts, acetylsalicylic acid is 4~5 parts, the tuber of stemona is 4~5 parts,
Uncaria is 5~6 parts.
According to parts by weight, Yolk immunoglobulin composition is 8 parts, Rabdosia rubescens is 7 parts, rhizoma corydalis is 5 parts, climbing groundsel
For 5 parts, camphor be 7 parts, alumen is 5 parts, acetylsalicylic acid is 5 parts, the tuber of stemona is 5 parts, uncaria is 6 parts.
Wherein, Yolk immunoglobulin composition is by with Candida albicans, staphylococcus aureus, large intestine bar
It is obtained after the strain mixt infected chicken that bacterium, Pseudomonas aeruginosa and this five kinds of pathogenic bacteria of A cluster Type B hemolytic streptococcus are formed special
Property albumen, to this five kinds of pathogenic bacteria have specificity antibacterial action, have good therapeutic effect to inflammation.
The preparation method of this Yolk immunoglobulin composition includes:
(1) by the bacterium after inactivation treatment according to Candida albicans 25~40%, staphylococcus aureus 20~25%, big
The ratio of enterobacteria 15~20%, Pseudomonas aeruginosa 10~15% and A cluster Type B hemolytic streptococcus 10~15% mixes, and obtains bacterium
Strain mixture；After strain mixt is dissolved, complex antigen is made；
Further, after strain mixt being dissolved, be made complex antigen the step of include: to mix dissolved bacterial strain
Body obtains the full bacterium complex antigen of emulsus, then the full bacterium of emulsus is compound with after not formula adjuvant is mixed according to mass ratio 1:0.5~1.5
Antigen crushing homogenizes.
Further, each bacterium colony ratio of strain mixt is prepared are as follows: Candida albicans 30~35%, Staphylococcus aureus
Bacterium 22~24%, Escherichia coli 16~19%, Pseudomonas aeruginosa 12~14% and A cluster Type B hemolytic streptococcus 12~14%.
(2) complex antigen is injected in chicken and carries out immunologic facilitation, collect the produced egg of chicken for passing through reinforced immunological,
It separates, purify from egg again.
Further, the step of immunologic facilitation is carried out with chicken includes: that complex antigen is injected in the pigeon breast of chicken and big
It is primary every the injection of reinforcing in 8~12 days at leg, it is immunized four times altogether.
Meanwhile the pharmaceutical composition for gynaecological inflammation disease also from it is clearing heat and detoxicating, dispel pathogenic wind and remove dampness, desinsection is antipruritic, detumescence
This four aspect connection and medication are relieved pain, specifically:
Rabdosia rubescens has effects that clearing heat and detoxicating, promoting blood circulation and stopping pain.
Chaulmoogra has effects that dispel pathogenic wind and remove dampness, detoxicating and destroying parasites.
Climbing groundsel has effects that clearing heat and detoxicating, dampness removing.
Camphor has effects that qi stagnation removing, wards off that foul, desinsection is antipruritic, swelling and pain relieving.
Alumen, the effect for having removing toxic substances desinsection, eliminating dampness antipruritic.
Acetylsalicylic acid has the function of analgesia, anti-inflammatory.
The tuber of stemona has the effect of desinsection and delousion.
Uncaria has effects that dispelling wind and relieving convulsion, The flat liver of heat-clearing.
The pharmaceutical composition by from it is clearing heat and detoxicating, dispel pathogenic wind and remove dampness, desinsection is antipruritic, in terms of swelling and pain relieving this four join and use
Medicine reduces the wet poison and wind toxin of patient's body, while desinsection is antipruritic, with removing damp-heat, the sense of discomfort of reduction of patient；It is aided with again
Swelling and pain relieving drug improves healing ability to mitigate the pain of patient.Pass through a variety of conjunctions having effects that between above-mentioned drug
Reason proportion, the pharmaceutical composition have very gynaecological imflammation, such as adnexitis, pelvic inflammatory disease, vaginitis etc. caused by invading in wet poison
Good curative effect, and have the characteristics that rapid-action, curative effect is good, have no toxic side effect.
It is a kind of above-mentioned for treating the preparation method of the pharmaceutical composition of gynaecological imflammation comprising:
According to parts by weight, by Rabdosia rubescens, rhizoma corydalis, climbing groundsel, the tuber of stemona and uncaria mix, according to solid-liquid ratio 1:4~6 with
Water mixing, extracts to obtain medical fluid using sound wave shock extraction method；
After medical fluid is mixed with alumen, camphor again, it is concentrated to give medicinal extract；
Medicinal extract is mixed with Yolk immunoglobulin composition, acetylsalicylic acid again, is dried in vacuo.
Further, the power of ultrasonic vibration extraction method is 120~150KHz, or is 125~145KHz, Huo Zhewei
135KHz；Ultrasonic time is 40~60min, is perhaps 45~55min or is 50min.
Further, it is dried in vacuo as frozen drying method.
This preparation method that present embodiment provides, used medicinal material is cheap and easy to get, and preparation method is simple, obtained
Pharmaceutical composition quality is high, good effect.
Feature and performance of the invention are described in further detail with reference to embodiments:
Embodiment 1
The present embodiment provides a kind of for treating the pharmaceutical composition of gynaecological imflammation comprising:
Yolk immunoglobulin composition 6Kg, Rabdosia rubescens 9Kg, rhizoma corydalis 7Kg, climbing groundsel 2Kg, camphor 5Kg, alumen
7Kg, acetylsalicylic acid 7Kg, tuber of stemona 2Kg and uncaria 3Kg.
Preparation method includes:
Rabdosia rubescens, rhizoma corydalis, climbing groundsel, the tuber of stemona and uncaria are mixed, mixed according to solid-liquid ratio 1:4 with water, using sound wave
Concussion extraction method is extracted to obtain medical fluid, and the power of ultrasonic vibration extraction method is 125KHz, time 60min；
After medical fluid is mixed with alumen, camphor again, it is concentrated to give medicinal extract；
Medicinal extract is mixed with Yolk immunoglobulin composition, acetylsalicylic acid again, is dried in vacuo.
Wherein, the preparation method of Yolk immunoglobulin composition includes:
By the bacterium after inactivation treatment according to Candida albicans 30%, staphylococcus aureus 20%, Escherichia coli 20%,
The mixing of the ratio of Pseudomonas aeruginosa 15% and A cluster Type B hemolytic streptococcus 15%, obtains strain mixt；By dissolved bacterial strain
Mixture obtains the full bacterium complex antigen of emulsus, then the full bacterium of the emulsus is answered with after not formula adjuvant is mixed according to mass ratio 1:1.5
It closes antigen crushing to homogenize, complex antigen is made；
The complex antigen is injected at the pigeon breast and thigh of chicken, it is primary every the injection of reinforcing in 12 days, it is immunized four times altogether,
The produced egg of chicken for passing through reinforced immunological is collected, then separates, purify from the egg.
Embodiment 2
The present embodiment provides a kind of for treating the pharmaceutical composition of gynaecological imflammation comprising:
Yolk immunoglobulin composition 10Kg, Rabdosia rubescens 6Kg, rhizoma corydalis 3Kg, climbing groundsel 5Kg, camphor 8Kg, alumen
3Kg, acetylsalicylic acid 3Kg, tuber of stemona 5Kg and uncaria 6Kg.
Preparation method includes:
Rabdosia rubescens, rhizoma corydalis, climbing groundsel, the tuber of stemona and uncaria are mixed, mixed according to solid-liquid ratio 1:6 with water, using sound wave
Concussion extraction method is extracted to obtain medical fluid, and the power of ultrasonic vibration extraction method is 150KHz, time 45min；
After medical fluid is mixed with alumen, camphor again, it is concentrated to give medicinal extract；
Medicinal extract is mixed with Yolk immunoglobulin composition, acetylsalicylic acid again, frozen drying to get.
Wherein, the preparation method of Yolk immunoglobulin composition includes:
By the bacterium after inactivation treatment according to Candida albicans 40%, staphylococcus aureus 25%, Escherichia coli 15%,
The mixing of the ratio of Pseudomonas aeruginosa 10% and A cluster Type B hemolytic streptococcus 10%, obtains strain mixt；By dissolved bacterial strain
Mixture obtains the full bacterium complex antigen of emulsus, then the full bacterium of the emulsus is answered with after not formula adjuvant is mixed according to mass ratio 1:0.5
It closes antigen crushing to homogenize, complex antigen is made；
The complex antigen is injected at the pigeon breast and thigh of chicken, it is primary every the injection of reinforcing in 8 days, it is immunized four times altogether,
The produced egg of chicken for passing through reinforced immunological is collected, then separates, purify from the egg.
Embodiment 3
The present embodiment provides a kind of for treating the pharmaceutical composition of gynaecological imflammation comprising:
Yolk immunoglobulin composition 8Kg, Rabdosia rubescens 7Kg, rhizoma corydalis 5Kg, climbing groundsel 5Kg, camphor 7Kg, alumen
5Kg, acetylsalicylic acid 5Kg, tuber of stemona 5Kg and uncaria 6Kg.
Preparation method includes:
Rabdosia rubescens, rhizoma corydalis, climbing groundsel, the tuber of stemona and uncaria are mixed, mixed according to solid-liquid ratio 1:5 with water, using sound wave
Concussion extraction method is extracted to obtain medical fluid, and the power of ultrasonic vibration extraction method is 135KHz, time 40min；
After medical fluid is mixed with alumen, camphor again, it is concentrated to give medicinal extract；
Medicinal extract is mixed with Yolk immunoglobulin composition, acetylsalicylic acid again, frozen drying to get.
Wherein, the preparation method of Yolk immunoglobulin composition includes:
By the bacterium after inactivation treatment according to Candida albicans 34%, staphylococcus aureus 24%, Escherichia coli 18%,
The mixing of the ratio of Pseudomonas aeruginosa 12% and A cluster Type B hemolytic streptococcus 12%, obtains strain mixt；By dissolved bacterial strain
Mixture obtains the full bacterium complex antigen of emulsus, then the full bacterium of the emulsus is compound with after not formula adjuvant is mixed according to mass ratio 1:1
Antigen crushing homogenizes, and complex antigen is made；
The complex antigen is injected at the pigeon breast and thigh of chicken, it is primary every the injection of reinforcing in 10 days, it is immunized four times altogether,
The produced egg of chicken for passing through reinforced immunological is collected, then separates, purify from the egg.
Embodiment 4
The present embodiment provides a kind of for treating the pharmaceutical composition of gynaecological imflammation comprising:
Yolk immunoglobulin composition 6Kg, Rabdosia rubescens 8Kg, rhizoma corydalis 5Kg, climbing groundsel 3Kg, camphor 6Kg, alumen
5Kg, acetylsalicylic acid 5Kg, tuber of stemona 3Kg and uncaria 4Kg.
Preparation method includes:
Rabdosia rubescens, rhizoma corydalis, climbing groundsel, the tuber of stemona and uncaria are mixed, mixed according to solid-liquid ratio 1:5 with water, using sound wave
Concussion extraction method is extracted to obtain medical fluid, and the power of ultrasonic vibration extraction method is 135KHz, time 50min；
After medical fluid is mixed with alumen, camphor again, it is concentrated to give medicinal extract；
Medicinal extract is mixed with Yolk immunoglobulin composition, acetylsalicylic acid again, frozen drying to get.
Wherein, the preparation method of Yolk immunoglobulin composition is as described in Example 3.
Embodiment 5
The present embodiment provides a kind of for treating the pharmaceutical composition of gynaecological imflammation comprising:
Yolk immunoglobulin composition 12Kg, Rabdosia rubescens 5Kg, rhizoma corydalis 2Kg, climbing groundsel 7Kg, camphor 9Kg, alumen
2Kg, acetylsalicylic acid 2Kg, tuber of stemona 7Kg and uncaria 7Kg.
Preparation method includes:
Rabdosia rubescens, rhizoma corydalis, climbing groundsel, the tuber of stemona and uncaria are mixed, mixed according to solid-liquid ratio 1:6 with water, using sound wave
Concussion extraction method is extracted to obtain medical fluid, and the power of ultrasonic vibration extraction method is 120KHz, time 55min；
After medical fluid is mixed with alumen, camphor again, it is concentrated to give medicinal extract；
Medicinal extract is mixed with Yolk immunoglobulin composition, acetylsalicylic acid again, frozen drying to get.
Wherein, the preparation method of Yolk immunoglobulin composition is as described in Example 3.
Experimental example
Below with reference to clinical test to the pharmaceutical composition provided in 1-5 of the embodiment of the present invention to the patient's of gynaecological imflammation
Therapeutic effect is evaluated:
One, testing program:
1. case selection:
This group of case is the gynaecological imflammation patient that the course of disease is more than 1 month, meet be included in, exclusion criteria, age 30-47
It is year, 38 years old average.6 groups are randomly divided into, every group each 30, wherein experimental group is the 1st~5 group, and control group is the 6th group.This 6 groups of trouble
There was no significant difference for the data such as age, the state of an illness of person, is comparable.
2. therapeutic scheme:
1st~5 group of (experimental group) patient takes orally the pharmaceutical composition that embodiment 1-5 is provided respectively, daily to take medicine three times, often
The dose of secondary medication is consistent.6th group of (control group) patient is treated using traditional remedies, that is, takes FUYANKANG JIAONANG.
Continuous treatment 1 month, does not use any analgesic drug product during treatment.
The physical condition of observation patient in one week treatment.
3. clinical evaluation standard:
Recovery from illness: under conditions of not depending on drug, the not clinical manifestation of gynaecological imflammation；
It is significant: under conditions of taking drugs, the state of an illness of patient is substantially reduced；
It improves: under conditions of taking drugs, the state of an illness of patient has a degree of mitigation；
It is invalid: to refer to that patient does not have to find the change of the state of an illness under conditions of taking the drug.
Two, test result:
It is as shown in table 1:
1. clinical test results of table
| Project | Recovery from illness | Significantly | It improves | In vain |
| Embodiment 1 | 22 | 6 | 2 | 0 |
| Embodiment 2 | 24 | 4 | 2 | 0 |
| Embodiment 3 | 27 | 2 | 1 | 0 |
| Embodiment 4 | 23 | 5 | 1 | 1 |
| Embodiment 5 | 23 | 4 | 2 | 1 |
| Control group | 9 | 14 | 6 | 1 |
As shown in Table 1:
Pharmaceutical composition provided in the present invention is excellent to the therapeutic effect of gynaecological imflammation, is mainly manifested in: after medication,
In the case where no use any anodyne, antibiotic, it can diminish inflammation, relieve pain.And it is provided in Examples 1 to 5
Pharmaceutical composition it is high to the treated effect of patient in 1 month, wherein recovery from illness and significant patient account for the 90% of sum with
On, thus illustrate that this pharmaceutical composition is good to the therapeutic effect of gynaecological imflammation, has the characteristics that rapid-action, curative effect is good.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from of the invention
Many other change and modification can be made in the case where spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of for treating the pharmaceutical composition of gynaecological imflammation, which is characterized in that described pharmaceutical composition is according to parts by weight
Include:
6~12 parts of Yolk immunoglobulin composition, 5~9 parts of Rabdosia rubescens, 2~7 parts of rhizoma corydalis, 2~7 parts of climbing groundsel, camphor 5
~9 parts, 2~7 parts of alumen, 2~7 parts of acetylsalicylic acid, 2~7 parts of the tuber of stemona, 3~7 parts of uncaria.
2. according to claim 1 for treating the pharmaceutical composition of gynaecological imflammation, which is characterized in that in parts by weight
Meter, the Yolk immunoglobulin composition is 6~10 parts, the Rabdosia rubescens is 6~8 parts, the rhizoma corydalis is 3~5 parts, institute
State that climbing groundsel is 3~5 parts, the camphor is 6~8 parts, the alumen is 3~5 parts, the acetylsalicylic acid is 3~5 parts, institute
State that the tuber of stemona is 3~5 parts, the uncaria is 4~6 parts.
3. according to claim 1 for treating the pharmaceutical composition of gynaecological imflammation, which is characterized in that in parts by weight
Meter, the Yolk immunoglobulin composition is 7~9 parts, the Rabdosia rubescens is 6~7 parts, the rhizoma corydalis is 4~5 parts, institute
State that climbing groundsel is 4~5 parts, the camphor is 6~7 parts, the alumen is 4~5 parts, the acetylsalicylic acid is 4~5 parts, institute
State that the tuber of stemona is 4~5 parts, the uncaria is 5~6 parts.
4. according to claim 1 for treating the pharmaceutical composition of gynaecological imflammation, which is characterized in that the yolk is immune
The preparation method of globulin composite includes:
By the bacterium after inactivation treatment according to Candida albicans 25~40%, staphylococcus aureus 20~25%, Escherichia coli
15~20%, the ratio of Pseudomonas aeruginosa 10~15% and A cluster Type B hemolytic streptococcus 10~15% mixes, and obtains bacterial strain mixing
Body；After strain mixt dissolution, complex antigen is made；
The complex antigen is injected in chicken and carries out immunologic facilitation, collects the produced egg of chicken for passing through reinforced immunological, then
It separates, purify from the egg.
5. according to claim 4 for treating the pharmaceutical composition of gynaecological imflammation, which is characterized in that mix the bacterial strain
After zoarium dissolution, the step of complex antigen is made includes: with not formula adjuvant by dissolved strain mixt according to mass ratio 1:
After 0.5~1.5 mixing, the full bacterium complex antigen of emulsus is obtained, then the full bacterium complex antigen crushing of the emulsus is homogenized.
6. according to claim 4 for treating the pharmaceutical composition of gynaecological imflammation, which is characterized in that carried out with chicken
The step of immunologic facilitation includes: that the complex antigen is injected at the pigeon breast and thigh of chicken, injects one every reinforcing in 8~12 days
It is secondary, it is immunized four times altogether.
7. according to claim 4 for treating the pharmaceutical composition of gynaecological imflammation, which is characterized in that prepare the bacterial strain
Each bacterium colony ratio of mixture are as follows: Candida albicans 30~35%, staphylococcus aureus 22~24%, Escherichia coli 16~
19%, Pseudomonas aeruginosa 12~14% and A cluster Type B hemolytic streptococcus 12~14%.
8. it is described in any item for treating the preparation method of the pharmaceutical composition of gynaecological imflammation according to claim 1~7, it is special
Sign is comprising:
According to parts by weight, the Rabdosia rubescens, the rhizoma corydalis, the climbing groundsel, the tuber of stemona and the uncaria are mixed, is pressed
It takes care of liquor ratio 1:4~6 to mix with water, extracts to obtain medical fluid using ultrasonic vibration extraction method；
After the medical fluid is mixed with the alumen, the camphor again, it is concentrated to give medicinal extract；
The medicinal extract is mixed with the Yolk immunoglobulin composition, the acetylsalicylic acid again, is dried in vacuo.
9. according to claim 8 for treating the preparation method of the pharmaceutical composition of gynaecological imflammation, which is characterized in that institute
The power for stating ultrasonic vibration extraction method is 120~150KHz, and the time is 40~60min.
10. according to claim 8 for treating the preparation method of the pharmaceutical composition of gynaecological imflammation, which is characterized in that
The vacuum drying is frozen drying method.
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Application publication date: 20190618 |