CN109890399A - 免疫原性精氨酸酶肽 - Google Patents

免疫原性精氨酸酶肽 Download PDF

Info

Publication number
CN109890399A
CN109890399A CN201780066414.6A CN201780066414A CN109890399A CN 109890399 A CN109890399 A CN 109890399A CN 201780066414 A CN201780066414 A CN 201780066414A CN 109890399 A CN109890399 A CN 109890399A
Authority
CN
China
Prior art keywords
seq
arginase
arg
peptide
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780066414.6A
Other languages
English (en)
Chinese (zh)
Inventor
M·H·安德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IO Biotech ApS
Original Assignee
IO Biotech ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IO Biotech ApS filed Critical IO Biotech ApS
Publication of CN109890399A publication Critical patent/CN109890399A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03001—Arginase (3.5.3.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201780066414.6A 2016-10-07 2017-10-06 免疫原性精氨酸酶肽 Pending CN109890399A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16192794.2 2016-10-07
EP16192794 2016-10-07
PCT/EP2017/075443 WO2018065563A1 (en) 2016-10-07 2017-10-06 Immunogenic arginase peptides

Publications (1)

Publication Number Publication Date
CN109890399A true CN109890399A (zh) 2019-06-14

Family

ID=57123856

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780066414.6A Pending CN109890399A (zh) 2016-10-07 2017-10-06 免疫原性精氨酸酶肽

Country Status (19)

Country Link
US (3) US10858642B2 (https=)
EP (2) EP4406613A3 (https=)
JP (1) JP7211938B2 (https=)
KR (1) KR102674521B1 (https=)
CN (1) CN109890399A (https=)
AU (1) AU2017341112B2 (https=)
CA (1) CA3039510A1 (https=)
DK (1) DK3522905T3 (https=)
ES (1) ES2992031T3 (https=)
FI (1) FI3522905T3 (https=)
HR (1) HRP20241486T1 (https=)
HU (1) HUE069077T2 (https=)
IL (1) IL265805B2 (https=)
LT (1) LT3522905T (https=)
MX (1) MX2019003970A (https=)
PL (1) PL3522905T3 (https=)
PT (1) PT3522905T (https=)
SI (1) SI3522905T1 (https=)
WO (1) WO2018065563A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113164545A (zh) * 2018-11-14 2021-07-23 Io生物技术公司 免疫原性精氨酸酶2多肽
CN114585650A (zh) * 2019-08-21 2022-06-03 癌症研究科技有限公司 与精氨酸酶ii（arg2）结合的分子

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017341112B2 (en) * 2016-10-07 2024-06-27 Io Biotech Aps Immunogenic arginase peptides
GB201815549D0 (en) * 2018-09-24 2018-11-07 Io Biotech Aps Arginase1 polypeptides
US20250327041A1 (en) 2022-02-24 2025-10-23 Io Biotech Aps Nucleotide delivery of cancer therapy
KR20240159833A (ko) 2022-02-24 2024-11-06 아이오 바이오테크 에이피에스 아르기나아제 2 백신

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006050313A2 (en) * 2004-10-29 2006-05-11 The Board Of Trustees Operating Michigan State University Protection against herbivores
WO2016102272A1 (en) * 2014-12-23 2016-06-30 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (hcc) and other cancers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US58767A (en) 1866-10-16 John brougjbton
US5554372A (en) 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US5780286A (en) 1996-03-14 1998-07-14 Smithkline Beecham Corporation Arginase II
US20110111424A1 (en) 2001-06-21 2011-05-12 Cell Signaling Technology, Inc. Analysis of ubiquitinated polypeptides
WO2003038444A2 (en) 2001-10-31 2003-05-08 Pfizer Products Inc. Biomarkers of liver function
CA2742497C (en) 2008-10-31 2024-01-23 George Georgiou Compositions of engineered human arginases and methods for treating cancer
WO2011008495A2 (en) * 2009-06-29 2011-01-20 The Board Of Regents Of The University Of Texas System Arginase formulations and methods
CN106456723B (zh) 2014-04-29 2021-03-09 康达医药科技有限公司 采用精氨酸酶i调节免疫系统的方法和组合物
AU2017341112B2 (en) * 2016-10-07 2024-06-27 Io Biotech Aps Immunogenic arginase peptides
JP7312106B2 (ja) * 2016-10-27 2023-07-20 アイオー バイオテック エーピーエス 新しいｐｄｌ２化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006050313A2 (en) * 2004-10-29 2006-05-11 The Board Of Trustees Operating Michigan State University Protection against herbivores
WO2016102272A1 (en) * 2014-12-23 2016-06-30 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (hcc) and other cancers

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113164545A (zh) * 2018-11-14 2021-07-23 Io生物技术公司 免疫原性精氨酸酶2多肽
CN113164545B (zh) * 2018-11-14 2026-04-10 Io生物技术公司 免疫原性精氨酸酶2多肽
CN114585650A (zh) * 2019-08-21 2022-06-03 癌症研究科技有限公司 与精氨酸酶ii（arg2）结合的分子

Also Published As

Publication number Publication date
MX2019003970A (es) 2019-12-05
KR20190077381A (ko) 2019-07-03
IL265805B1 (en) 2024-04-01
PT3522905T (pt) 2024-10-02
AU2017341112A1 (en) 2019-05-02
IL265805A (en) 2019-06-30
DK3522905T3 (da) 2024-10-21
JP2019537562A (ja) 2019-12-26
WO2018065563A1 (en) 2018-04-12
IL265805B2 (en) 2024-08-01
KR102674521B1 (ko) 2024-06-11
EP3522905A1 (en) 2019-08-14
US10858642B2 (en) 2020-12-08
EP4406613A2 (en) 2024-07-31
SI3522905T1 (sl) 2025-02-28
HUE069077T2 (hu) 2025-02-28
CA3039510A1 (en) 2018-04-12
LT3522905T (lt) 2024-11-11
FI3522905T3 (fi) 2024-10-31
EP3522905B1 (en) 2024-09-25
ES2992031T3 (es) 2024-12-05
EP4406613A3 (en) 2024-10-23
HRP20241486T1 (hr) 2025-01-03
US11981944B2 (en) 2024-05-14
US20190338270A1 (en) 2019-11-07
US20240167013A1 (en) 2024-05-23
PL3522905T3 (pl) 2025-01-07
JP7211938B2 (ja) 2023-01-24
AU2017341112B2 (en) 2024-06-27
US20210139877A1 (en) 2021-05-13

Similar Documents

Publication Publication Date Title
CN109890399A (zh) 免疫原性精氨酸酶肽
JP5393144B2 (ja) Ｈｌａ−ａ＊３３０３拘束性ｗｔ１ペプチド、およびそれを含む医薬組成物
CN109152830A (zh) 用于免疫疗法的核/壳结构平台
CN113966342A (zh) TGF-β疫苗
JP2023109840A (ja) 新しいｐｄｌ２化合物
ES2510493T3 (es) Epítopos T CD4+ de la Survivina y sus aplicaciones
HK1215264A1 (zh) Mhc ii类分子提呈的存活蛋白(survivin)的部分肽及其利用方法
HK40012895B (en) Immunogenic arginase peptides
HK40012895A (en) Immunogenic arginase peptides
CN109069574A (zh) 用于治疗黑色素瘤的方法和组合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination