CN109862899A - 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法 - Google Patents

治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法 Download PDF

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Publication number
CN109862899A
CN109862899A CN201780050143.5A CN201780050143A CN109862899A CN 109862899 A CN109862899 A CN 109862899A CN 201780050143 A CN201780050143 A CN 201780050143A CN 109862899 A CN109862899 A CN 109862899A
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China
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composition
chitosan
freeze
serum
drying
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CN201780050143.5A
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English (en)
Chinese (zh)
Inventor
M.B.道林
S.E.拉扎
H.M.金泰尔
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Eye Care International LLC
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Eye Care International LLC
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Publication of CN109862899A publication Critical patent/CN109862899A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4869—Determining body composition
    • A61B5/4875—Hydration status, fluid retention of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CN201780050143.5A 2016-06-16 2017-06-16 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法 Pending CN109862899A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662350772P 2016-06-16 2016-06-16
US62/350772 2016-06-16
PCT/US2017/037954 WO2017218942A1 (en) 2016-06-16 2017-06-16 Compositions and methods of treating dry syndrome and other traumatized non-keratinized epithelial surfaces

Publications (1)

Publication Number Publication Date
CN109862899A true CN109862899A (zh) 2019-06-07

Family

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CN201780050143.5A Pending CN109862899A (zh) 2016-06-16 2017-06-16 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法

Country Status (6)

Country Link
US (4) US11191781B2 (enExample)
EP (1) EP3471742A4 (enExample)
JP (3) JP7148987B2 (enExample)
CN (1) CN109862899A (enExample)
CA (1) CA3027969A1 (enExample)
WO (1) WO2017218942A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117017945A (zh) * 2023-08-14 2023-11-10 珠海横琴澳叶健康科技有限公司 一种离子响应型蒙花苷纳米粒子及其制备方法和应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109862899A (zh) 2016-06-16 2019-06-07 护眼国际有限责任公司 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法
WO2019231133A1 (ko) * 2018-05-31 2019-12-05 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물
US20200170998A1 (en) * 2018-11-29 2020-06-04 Cellula Llc Umbilical cord blood serum and umbilical cord blood plasma preparation in combination with a nonsteroidal anti-inflammatory drug and freeze-drying the composition
KR20220008289A (ko) * 2019-05-13 2022-01-20 본 테라퓨틱스 소시에테아노님 히알루론산 및 혈장 단백질을 포함하는 개선된 동결건조 제형 및 이의 용도
IT201900010740A1 (it) * 2019-07-02 2021-01-02 Medacta Int Sa Biocompatible compositions comprising a biocompatible thickening polymer and a chitosan derivative
EP4549859A1 (en) * 2022-06-28 2025-05-07 Compliance Consulting And Engineering Services, S.L. System for controlling the freeze-drying process in a freeze dryer with a plate stack system and a method for generating a design space
US20240226181A1 (en) * 2023-01-11 2024-07-11 Biostem Technologies, Inc. Human umbilical cord composition for treatment of peyronie's disease
WO2025165681A1 (en) * 2024-01-31 2025-08-07 Serorepair Llc Serum compositions with additive for ocular delivery in animals
CN118662706B (zh) * 2024-06-17 2025-01-10 韶关朗圣药业有限公司 一种人体润滑液及其制备方法和应用
EP4740931A1 (en) * 2024-11-06 2026-05-13 Oral Care Solutions GmbH Oral care composition for use in the treatment of dry mouth

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1668317A (zh) * 2002-05-09 2005-09-14 医学基因公司 用于处理伤口的含血浆或血清的药物组合物
WO2015123778A1 (en) * 2014-02-20 2015-08-27 Polyvalor, Limited Partnership Freeze-dried polymer compositions for mixing with platelet rich plasma to form implants for tissue repair and/or compositions for therapeutic intra-articular injections

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713980D0 (en) 1997-07-03 1997-09-10 Danbiosyst Uk New conjugates
PT1128809E (pt) * 1998-11-20 2005-04-29 Medidom Lab Formulacoes oftalmicas aquosas comprendendo quitosano
US20080299212A1 (en) * 2005-02-25 2008-12-04 Medigenes Co., Ltd Pharmaceutical Composition for Treating Avellino Cornea Dystrophy Comprising Blood Plasma or Serum
ES2668551T3 (es) * 2005-09-26 2018-05-18 Lifecell Corporation Composición seca de plaquetas
WO2007059084A2 (en) * 2005-11-14 2007-05-24 The New England Medical Center Hospitals, Inc. Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
US20090223080A1 (en) * 2007-03-19 2009-09-10 Hemcon Medical Technologies, Inc. Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma
US7776022B2 (en) * 2007-03-19 2010-08-17 Hemcon Medical Technologies Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma
WO2010085792A1 (en) * 2009-01-26 2010-07-29 Oregon Biomedical Engineering Institute Dehydrated plasma kit
CN101829048B (zh) * 2010-01-21 2012-04-18 厦门大学 一种滴眼液及其制备方法
WO2013003356A1 (en) 2011-06-27 2013-01-03 Emory University Compositions, uses, and preparation of platelet lysates
ES2368394B1 (es) * 2011-07-13 2012-06-08 Banc De Sang I Teixits Composición que comprende plasma de sangre de cordon umbilical para el tratamiento de patologías de la superficie ocular y procedimiento de obtención de la misma.
US9688434B2 (en) * 2012-08-17 2017-06-27 Archon Pharmaceutical Consulting Llc System for compounding and packaging ready to reconstitute ophthalmic drug powders to a solution or to a suspension for administration to an eye of patient
CA2914610C (en) 2013-03-13 2022-08-02 University Of Maryland Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
WO2015048774A2 (en) 2013-09-30 2015-04-02 Bioactive Regenerative Therapeutics, Inc. Biomimetic hybrid gel compositions and methods of use
WO2015142853A1 (en) * 2014-03-17 2015-09-24 Encompass Development, Inc. Ocular formulations
EP3139903B1 (en) * 2014-05-07 2019-07-03 Croma-Pharma Gesellschaft m.b.H. Aqueous ophthalmic solution and method for treating dry eye syndrome
CA2963435A1 (en) 2014-10-06 2016-04-14 Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico Umbilical cord blood plasma for treatment of corneal pathology
DE102015205293A1 (de) * 2015-03-24 2016-09-29 Marc Schrott Verfahren zur Herstellung von Augentropfen
CN109862899A (zh) 2016-06-16 2019-06-07 护眼国际有限责任公司 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1668317A (zh) * 2002-05-09 2005-09-14 医学基因公司 用于处理伤口的含血浆或血清的药物组合物
WO2015123778A1 (en) * 2014-02-20 2015-08-27 Polyvalor, Limited Partnership Freeze-dried polymer compositions for mixing with platelet rich plasma to form implants for tissue repair and/or compositions for therapeutic intra-articular injections

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KUTLU,B. 等: "Platelet-rich plasma-loaded chitosan scaffolds: preparation and growth factor release kinetics", 《JOURNAL OF BIOMEDICAL MATERIALS RESEARCH B: APPLIED BIOMATERIALS》 *
YOON,K.等: "Comparison of Autologous Serum and Umbilical Cord Serum Eye Drops for Dry Eye Syndrome", 《AMERICAN JOURNAL OF OPHTHALMOLOGY》 *
边德换等: "干眼的药物治疗现状及进展", 《当代医学》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117017945A (zh) * 2023-08-14 2023-11-10 珠海横琴澳叶健康科技有限公司 一种离子响应型蒙花苷纳米粒子及其制备方法和应用

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JP2022191232A (ja) 2022-12-27
US12661374B2 (en) 2026-06-23
JP7473237B2 (ja) 2024-04-23
JP7148987B2 (ja) 2022-10-06
EP3471742A1 (en) 2019-04-24
CA3027969A1 (en) 2017-12-21
WO2017218942A8 (en) 2019-01-24
US20260151428A1 (en) 2026-06-04
US20220168341A1 (en) 2022-06-02
US20190175647A1 (en) 2019-06-13
US11534459B2 (en) 2022-12-27
US20230321145A1 (en) 2023-10-12
US11191781B2 (en) 2021-12-07
JP2024096781A (ja) 2024-07-17
EP3471742A4 (en) 2020-03-04
WO2017218942A1 (en) 2017-12-21
JP2019525951A (ja) 2019-09-12

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