CA3027969A1 - Compositions and methods of treating dry eye syndrome and other traumatized non-keratinized epithelial surfaces - Google Patents

Compositions and methods of treating dry eye syndrome and other traumatized non-keratinized epithelial surfaces Download PDF

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Publication number
CA3027969A1
CA3027969A1 CA3027969A CA3027969A CA3027969A1 CA 3027969 A1 CA3027969 A1 CA 3027969A1 CA 3027969 A CA3027969 A CA 3027969A CA 3027969 A CA3027969 A CA 3027969A CA 3027969 A1 CA3027969 A1 CA 3027969A1
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CA
Canada
Prior art keywords
composition
chitosan
serum
freeze
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3027969A
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English (en)
French (fr)
Inventor
Matthew B. Dowling
Steven E. Lazar
Helga M. Gentile
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eye Care International LLC
Original Assignee
Eye Care International LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eye Care International LLC filed Critical Eye Care International LLC
Publication of CA3027969A1 publication Critical patent/CA3027969A1/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/16Blood plasma; Blood serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4869Determining body composition
    • A61B5/4875Hydration status, fluid retention of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/51Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CA3027969A 2016-06-16 2017-06-16 Compositions and methods of treating dry eye syndrome and other traumatized non-keratinized epithelial surfaces Pending CA3027969A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662350772P 2016-06-16 2016-06-16
US62/350,772 2016-06-16
PCT/US2017/037954 WO2017218942A1 (en) 2016-06-16 2017-06-16 Compositions and methods of treating dry syndrome and other traumatized non-keratinized epithelial surfaces

Publications (1)

Publication Number Publication Date
CA3027969A1 true CA3027969A1 (en) 2017-12-21

Family

ID=60663416

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3027969A Pending CA3027969A1 (en) 2016-06-16 2017-06-16 Compositions and methods of treating dry eye syndrome and other traumatized non-keratinized epithelial surfaces

Country Status (6)

Country Link
US (3) US11191781B2 (enExample)
EP (1) EP3471742A4 (enExample)
JP (3) JP7148987B2 (enExample)
CN (1) CN109862899A (enExample)
CA (1) CA3027969A1 (enExample)
WO (1) WO2017218942A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3027969A1 (en) 2016-06-16 2017-12-21 Eye Care International, Llc Compositions and methods of treating dry eye syndrome and other traumatized non-keratinized epithelial surfaces
WO2019231133A1 (ko) * 2018-05-31 2019-12-05 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물
US20200170998A1 (en) * 2018-11-29 2020-06-04 Cellula Llc Umbilical cord blood serum and umbilical cord blood plasma preparation in combination with a nonsteroidal anti-inflammatory drug and freeze-drying the composition
TW202108128A (zh) * 2019-05-13 2021-03-01 比利時商布恩醫療公司 經改良之與玻尿酸與血漿蛋白有關之冷凍乾燥調配物及其用途
IT201900010740A1 (it) * 2019-07-02 2021-01-02 Medacta Int Sa Biocompatible compositions comprising a biocompatible thickening polymer and a chitosan derivative
US20240226181A1 (en) * 2023-01-11 2024-07-11 Biostem Technologies, Inc. Human umbilical cord composition for treatment of peyronie's disease
CN117017945A (zh) * 2023-08-14 2023-11-10 珠海横琴澳叶健康科技有限公司 一种离子响应型蒙花苷纳米粒子及其制备方法和应用
WO2025165681A1 (en) * 2024-01-31 2025-08-07 Serorepair Llc Serum compositions with additive for ocular delivery in animals
CN118662706B (zh) * 2024-06-17 2025-01-10 韶关朗圣药业有限公司 一种人体润滑液及其制备方法和应用

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GB9713980D0 (en) 1997-07-03 1997-09-10 Danbiosyst Uk New conjugates
PT1128809E (pt) 1998-11-20 2005-04-29 Medidom Lab Formulacoes oftalmicas aquosas comprendendo quitosano
KR100518152B1 (ko) * 2002-05-09 2005-09-29 메디제네스(주) 혈장 또는 혈청을 함유한 창상 치료용 약학 조성물
WO2006091038A1 (en) * 2005-02-25 2006-08-31 Medigenes Co., Ltd. Pharmaceutical composition for treating avellino cornea dystrophy comprising blood plasma or serum
WO2007038629A2 (en) * 2005-09-26 2007-04-05 Lifecell Corporation Dry platelet composition
US20090170059A1 (en) 2005-11-14 2009-07-02 Hans Klingemann Methods for Preparing Cord Matrix Stem Cells (CMSC) for Long Term Storage and for Preparing a Segment of umbilical cord for cryopreservation
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
US7776022B2 (en) 2007-03-19 2010-08-17 Hemcon Medical Technologies Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma
US20090223080A1 (en) * 2007-03-19 2009-09-10 Hemcon Medical Technologies, Inc. Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma
US20110282325A1 (en) 2009-01-26 2011-11-17 Ore-gon Biomedical Engineering Institute Dehydrated plasma kit
CN101829048B (zh) * 2010-01-21 2012-04-18 厦门大学 一种滴眼液及其制备方法
ES2368394B1 (es) * 2011-07-13 2012-06-08 Banc De Sang I Teixits Composición que comprende plasma de sangre de cordon umbilical para el tratamiento de patologías de la superficie ocular y procedimiento de obtención de la misma.
WO2014028745A2 (en) 2012-08-17 2014-02-20 Archon Pharmaceutical Consulting Llc A system for compounding and packaging ready to reconstitute drug powders of solutions to a solution or to a suspension or to an injectable
US9616088B2 (en) 2013-03-13 2017-04-11 Gel-E, Inc. Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
WO2015048774A2 (en) * 2013-09-30 2015-04-02 Bioactive Regenerative Therapeutics, Inc. Biomimetic hybrid gel compositions and methods of use
ES2904359T3 (es) 2014-02-20 2022-04-04 Ortho Regenerative Tech Inc Composiciones poliméricas liofilizadas para mezclar con plasma rico en plaquetas para formar implantes para la reparación de tejidos y/o composiciones para inyecciones terapéuticas intraarticulares
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DE102015205293A1 (de) * 2015-03-24 2016-09-29 Marc Schrott Verfahren zur Herstellung von Augentropfen
CA3027969A1 (en) 2016-06-16 2017-12-21 Eye Care International, Llc Compositions and methods of treating dry eye syndrome and other traumatized non-keratinized epithelial surfaces

Also Published As

Publication number Publication date
JP2019525951A (ja) 2019-09-12
WO2017218942A8 (en) 2019-01-24
US20230321145A1 (en) 2023-10-12
CN109862899A (zh) 2019-06-07
EP3471742A1 (en) 2019-04-24
US11534459B2 (en) 2022-12-27
JP7148987B2 (ja) 2022-10-06
EP3471742A4 (en) 2020-03-04
JP2024096781A (ja) 2024-07-17
JP7473237B2 (ja) 2024-04-23
US11191781B2 (en) 2021-12-07
JP2022191232A (ja) 2022-12-27
WO2017218942A1 (en) 2017-12-21
US20220168341A1 (en) 2022-06-02
US20190175647A1 (en) 2019-06-13

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