CN109846993A - It is a kind of to treat cough Chinese materia medica preparation and preparation method - Google Patents
It is a kind of to treat cough Chinese materia medica preparation and preparation method Download PDFInfo
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Abstract
Cough Chinese materia medica preparation and preparation method are treated the invention discloses a kind of, belong to Traditional Chinese medicine formula preparation technical field, the present invention provides a kind of for the weak caused weakened body resistance humidity hysteresis cough obstinate problem of gas to deficiency of the spleen-yin in the prior art, provides the Chinese materia medica preparation and preparation method of a kind for the treatment of cough to show unique characteristics.The present invention forms the formula of the Chinese materia medica preparation using adenophora tetraphylla, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, moxibustion Radix Glycyrrhizae, dried orange peel, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Ophiopogonis, Schisandra chinensis, semen armeniacae amarae, campanulaceae, mulberry skin, Radix Angelicae Sinensis, PERICARPIUM TRICHOSANTHIS, cordate houttuynia, polygonum cuspidate, achieve the effect that treating both manifestation and root cause of disease, the cureless chronic cough of conventional method is especially used to treatment cough, with significant curative effect, it is worth in clinical wide popularization and application.
Description
Technical field
Cough Chinese materia medica preparation and preparation method are treated the present invention relates to a kind of, for treating the Chinese medicine preparation system of cough
Agent belongs to Traditional Chinese medicine formula preparation technical field.
Background technique
Cough is clinically widest a kind of disease, and chronic cough is very common, so-called chronic cough, substantially one
Kind common symptoms.The course of disease is shown as two months or more or intermittent phase in 3~6 weeks, the Clinics and Practices guide of cough
(2015) defining chronic cough is greater than 8 weeks [Chinese tuberculosis and breathing the 5th phase of volume 39 magazine in May, 2016], and cough is repeatedly
Breaking-out, the numerous confused complexity of the cause of disease, protracted course is with the passing of time.According to the difference of Etiology And Character, clinical symptoms show as diversification, and the rules for the treatment of are each
Different, card type is various, it is difficult to hold.It not only allows patient puzzled painful, also makes many clinical doctors helpless.It finds relatively simple and direct
Method hold letter and drive numerous, solve the chronic cough for treating multifactor more interpretation of the cause, onset and process of an illness, become the important topic that medical field faces.
The present inventor is mentioned by nearly clinical research in 40 years and experience accumulation according to " spleen yin card is controlled " system from wound
Out " spleen yin be in the sheet of the foundation of acquired constitution this ", a series of creative academic ideas such as " change of spleen yin disease is divided into actual situation ", from unique
Visual angle discloses the memory mechanism and Clinical symptoms of syndrome of deficiency of spleen yin and spleen yin real example in a variety of diseases, has walked out forefathers and has recognized in spleen yin
Blind area, theoretic forbidden zone in knowledge and mistaken ideas clinically are put forward for the first time and have practiced the nature and flavor for growing spleen drug and classification, opinion
It has demonstrate,proved the deficiency of the spleen-yin syndrome of deficiency of stomach yin and has controlled difference, formulated diagnostic criteria, Selection drug standard and the curative effect of " syndrome of deficiency of spleen yin and real example "
Judgment criteria, creation have summed up the spleen yin clinical diagnosis and treatment system of complete set, while specification cures large quantities of chronic coughs,
Refractory intractable chronic cough is controlled long for a variety of methods, more creates that a set of to have theoretical grounding in basic skills to make basis, clinical efficacy aobvious
It writes, the treatment method of application method simplicity, and refines and be created that adding for experience Serial Prescription " growing spleen cough-relieving side " and its component and amount
Subtract series, " treatment cough Chinese materia medica preparation " of the invention is one of the concrete application of " the growing spleen cough-relieving side ", and the present invention is
The breakthrough of one under the spleen yin theoretical direction traditional Chinese medical science field clinical practice for thering is theoretical system to coach." in treatment cough
The unique formula thinking of medicine preparation " adds and subtracts proportion and its specific preparation method by series, is invented and is solved with creative labor
The wet note of spleen deficiency of having determined, chronic cough are not cured a key technical problem of this historical difficulty, and clinical practice is tired for many years to control tired effect.
Summary of the invention
The present invention is guidance using the theoretical combination principle of spleen yin, solves for illnesss such as chronic cough obstinates
Treat chronic cough obstinate problem.It provides and shows unique characteristics and the complete Chinese medicinal formulae of therapy and formula, the present inventor is thus
The further investigation of many years has been carried out, and has helped auxiliary other tastes again after finally found that adenophora tetraphylla, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, the combination of moxibustion Radix Glycyrrhizae
Medicine has the effective cure rate significantly improved for chronic cough.Spleen yin is seen based on above-mentioned discovery and further directed to cough
Empty wet tired card or the deficiency of the spleen-yin yin deficiency affecting yang, disturbance of body-fluid metabolism and in cold-dampness raw or eating cold and uncooked food excessively or it is raw it is outer invade, the dysfunction of the spleen in transport,
Lifting is lacked of proper care, white and greasy fur, the research point of the chronic cough disease of all polymorphic types such as raw and wet tired spleen fortune in soft and moderate pulse and water-wet
Analysis, this prescription of innovation and creation.Chinese medicine preparation is perfect by transporting and transforming function of the spleen and stomach function, improves body's immunity, ridging life
Gold receives the effect of expelling phlegm and arresting coughing by the behave for the treatment of both manifestation and root cause of disease, has significant curative effect to chronic cough, to solve to control long
Cough more does not provide the clinical recipe with practical value.In order to solve the above technical problems, the present invention is using following
Technical solution.
Specific embodiment:
The present invention treats cough Chinese materia medica preparation prescription by the Chinese medicinal composition of following parts by weight: 88~16 parts of adenophora tetraphylla, rhizoma pinellinae praeparata
44~8 parts, 44~8 parts of Radix cynanchi wilfordii, 48~8 parts of moxibustion Radix Glycyrrhizae, 37~7 parts of dried orange peel, 66~12 parts of Rhizoma Atractylodis Macrocephalae, 44~8 parts of Poria cocos, Radix Ophiopogonis
66~12 parts, 22~4 parts of Schisandra chinensis, 44~8 parts of semen armeniacae amarae, 49~9 parts of campanulaceae, 37~7 parts of mulberry skin, 44~8 parts of Radix Angelicae Sinensis, Snakegourd Fruit
66~12 parts of skin, 133~23 parts of cordate houttuynia, 112~20 parts of polygonum cuspidate.The every taste medicinal material efficacy effect used is respectively as follows:.
Adenophora tetraphylla: for Campanulaceae adenophora tetraphylla Adenophora tetraphylla (Thunb.) Fisch. or sand
Join the dry root of Adenophora stricta Miq..Nourishiing yin to clear away the lung-heat, reinforcing stomach reg fluid, resolving sputum, QI invigorating.For lung-heat type cough,
Deficiency of yin and overstrain cough, dry cough phlegm is glutinous, deficiency of stomach-Yin, deficiency of food vomiting, deficiency of both vital energy and Yin, restlessness and fever with thirst.
Rhizoma pinellinae praeparata: for the dry tuber of aroid tuber of pinellia Pinellia ternata (Thunb.) Breit..
It is eliminating dampness and eliminating phlegm.For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache.
Radix cynanchi wilfordii: for Asclepiadaceae Cynanchum plant cynanchum wilfordii Cynanchum wilfordii (Maxim.) Hemsl.,
It is used as medicine with root tuber.Nourishing liver and kidney strengthening the bones and muscles, benefiting essence-blood reinforcing spleen to promote digestion detoxification sore treatment.Waist and knee ache is cured mainly, impotence and seminal emission is dizzy
Tinnitus, palpitation and insomnia, loss of appetite, infantile malnutrition, postpartum milk is rare, sore, carbuncle and painful swelling venomous snake bite.
Radix glycyrrhizae preparata: for glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix
The dry root of Glycyrrhiza inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..Radix glycyrrhizae preparata: it mends
Spleen stomach function regulating, Yiqi and vein recovery.Spleen and stomach function decline is cured mainly, big loose stool is thin, fever out of strength and cough, palpitaition, knotted pulse, detachable
Sub- poison etc..
Dried orange peel: for rutaceae orange Citrus reticulata Blanco and its drying and ripening fruit of variety
Skin.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For abdominal fullness and distention, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Rhizoma Atractylodis Macrocephalae: for the dry rhizome of compositae plant Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Invigorating the spleen benefit
Gas, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, threatened abortion.
Poria cocos: this product is the dry sclerotia of polyporaceae fungus Poria cocos (Schw.) Wolf.Li Shui seeps
It is wet, invigorating the spleen, calming heart.For edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Radix Ophiopogonis: for liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl.'s
Dried root.Nourishing Yin and promoting production of body fluid, moistening lung and clearing away the heart-fire.For dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, Heat Diabetes,
Vexed insomnia, dry constipation of intestines.
Schisandra chinensis: for being dried to for magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill.
Ripe fruit.Astringency inducing, supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves.For long-last cough and virtual asthma, emission, enuresis frequent micturition, endless diarrhea, from
Sweat night sweat, injury thirst, Heat Diabetes, palpitation and insomnia.
Semen armeniacae amarae: for Xu Wei section plant ansu apricot Armeniaca vulgaris Lam. [Prunus armeniaca L white peony root
Dry mature seed.Sending down abnormally ascending is relieving cough and asthma, relax bowel and defecation.For cough and asthma, fullness sensation in chest abundant expectoration, dry constipation of intestines.
Campanulaceae: for the dry root of Campanulaceae campanulaceae Platycodon grandiflorum (Jacq.) A.DC.A surname
Lung, relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, chest distress, pharyngalgia hoarse voice, lung carbuncle pyemesis
Mulberry skin: for the dry root skin of moraceae plants mulberry Morus alba L..Removing heat from lung and relieving asthma；Inducing diuresis for removing edema.Main lung heat breathes heavily phlegm；Water
Drink stops lung；Turgor asthma is anxious；Oedema；Tinea pedis；Difficult urination.
Radix Angelicae Sinensis: for the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.It enriches blood work
Blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatism numbness
Bitterly, traumatic injury, ulcer sores, dry constipation of intestines.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine blood circulation.For amenorrhea and algomenorrhea, rheumatic arthralgia, traumatic injury.
PERICARPIUM TRICHOSANTHIS: for cucurbitaceous plant snakegourd Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harms
The dry mature skin of Trichosanthes rosthornii Harms.Moistening lung, resolving sputum, dissipating bind, ease constipation.Phlegm-heat cough is controlled,
Thoracic obstruction, accumulation of pathogens in chest, consumptive lung disease hemoptysis are quenched one's thirst, jaundice, constipation, carbuncle swells from the beginning of.
Cordate houttuynia: for the fresh herb or dry ground of saururaceae plant houttuynia cordata Houttuynia cordata Thunb.
Upper part.It is clearing heat and detoxicating, the carbuncle that disappears apocenosis, inducing diuresis for treating strangurtia.For lung carbuncle pyemesis, phlegm heat panting cough, hot dysentery, heat gonorrhea, carbuncle sore tumefacting virus.
Polygonum cuspidate: for the dry rhizome and root of few section's plant polygonum cuspidatum Polygonum cuspidatum Sieb. et Zucc..
Removing dampness through diuresis and removing jaundice, clearing heat and detoxicating, removing blood stasis and acesodyne is relieving cough and reducing sputum.For jaundice with damp-heat pathogen, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus,
Scald, menostasis , Disorder lump in the abdomen, traumatic injury, cough with lung heat.
Auxiliary material: the auxiliary material of addition is needed in various dosage form manufacturing process.
Steviosin: for the mixing glycosides based on Steviosin (C38H60018).
Starch: caryopsis or euphorbia plant cassava for gramineae plant maize ZeamaysL.
Polysaccharide particle obtained in the root tuber of Manihotutilissima Pohl..
Refined honey: it is refined by honey (GB14963-2011), refined honey water content is about 10.0%~13.0%.
Combination principle:
It combination principle of the invention described below and dialectical treats.
Numerous published Chinese traditional treatment coughs can be retrieved from patent database and national data in literature library searching " cough "
Patent document and paper, from numerous published documents it is found that being all mostly in the combination principle and treatment method of its prescription
Traditional theory of traditional Chinese medical science or hospital handed down from one's ancestors is utilized to solve the technical problem for the treatment of cough, theory is nearly all established
It is effective to many cough diseases are treated on the basis of spleen sun, temper and stomach-Yin.But it is clinical also common to have part slow
Property cough treat weary effect or unsatisfactory curative effect, and clinical findings are not within minority.For the chronic cough illness for treating weary effect, originally
Invention used through the present inventor nearly 40 years summary of experience spleen yin clinical diagnosis and treatment method, creation it is deficiency of the spleen-yin theory [in
Cure No. 180 scientific and technical literature publishing houses of spleen yin theory research Tang Yixin (Beijing) New Gordon word and publish in August, 1992], record
Enter spleen yin theory [the Chinese medicine basic medical-higher learning of Chinese medicine-religion of the present inventor of national Chinese medicine industry higher education teaching material
Material ISBN978-7-5132-0853-6CIP data core word (2012) the 069482nd] etc. works, form spleen yin reason
By the combination principle and its theoretical system of the lower treatment chronic cough of guidance.
The present inventor has made intensive studies and finally found that adenophora tetraphylla, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, the combination of moxibustion Radix Glycyrrhizae
Helping auxiliary other taste medical instruments again afterwards has effective healing for chronic cough.Current analysis finds the chemical combination composition of the four traditional Chinese medicine
Are as follows: adenophora tetraphylla has more than 4 kinds and breakdown [Chinese book on Chinese herbal medicine P290~P291], and rhizoma pinellinae praeparata has as many as 60 kinds and the breakdown [whole nation
Chinese herbal medicine collects (second edition) (first volume) P233~P234], Radix cynanchi wilfordii has more than 4 kinds and breakdown [national Chinese herbal medicine compilation (the
Two editions) (volume two) P600~P601], moxibustion Radix Glycyrrhizae is more than 4 kinds and breakdown [national Chinese herbal medicine compilation (second edition) (first volume) P242
~P243].There are also more chemical analysis discovery to be analyzed for the four traditional Chinese medicine.It is unexpected after utilizing " deficiency of the spleen-yin " theory to be combined
Discovery have peculiar curative effect to chronic cough.The specific disease of chronic cough clinic disease is directed in research process of the invention
Machine, according to the deficiency of spleen-YIN deficiency of Yin, gas is weak, and weakened body resistance heresy is caused to be invaded, actual situation mutually and, along internal organs mutually thus disease and liver, kidney, the heart, lung,
The possible disease by core of spleen asthenia and dampness retention and the relevant diseases of the vital organs of the human body using deficiency of spleen-YIN as basic pathogenesis occurs, is formed
Related multidimensional data relationship is confused, and difficulty divides cause and effect, and variable mixes, and multiple cause and effect leads to the multifactor disease knot of cause and effect hard to say
Fruit.For chronic cough caused by various factors, present invention adenophora tetraphylla compatibility rhizoma pinellinae praeparata, Radix cynanchi wilfordii stop with having certain qi-restoratives
Four taste of moxibustion Radix Glycyrrhizae of cough effect is combined into main ingredient.Face card thinking in line with " searching for the primary cause of disease in treatment, this is in primary and giving consideration to both the incidental and fundamental ", creates
Out for pertinacious chronic cough spleen asthenia and dampness retention, body ressitance weakened while pathogenic factors prevailing, treating both manifestation and root cause of disease special effect tcm prescription.
The drug that the present invention dexterously emphasizes particularly on different fields adenophora tetraphylla, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, several effects of moxibustion Radix Glycyrrhizae, takes it
Stress that A myriad of stars surround the moon, be condensed into different pharmaceutical close and the one group of Fuzheng Jiedu formed, the strain formula that cough-relieving qi-restoratives is common effect
Type is combined and is collectively formed as the main ingredient of we.The chronic cough deficiency syndrome of the lung, it is empty then control its mother, the deficiency of spleen-YIN deficiency of Yin and gas is weak, retention of spleen-dampness,
But method of the yin without rapid benefit, qi being the governor of blood, symptomatic treatment in acute condition of curing the disease, QI invigorating are that yin-nourishing is first.Adenophora tetraphylla is described cold nature；Taste
It is sweet；It attaches to the lung and stomach meridians, effect " nourishiing yin to clear away the lung-heat, resolving sputum, QI invigorating.For: lung-heat type cough, deficiency of yin and overstrain cough, dry cough phlegm is glutinous, and gas yin is not
One of the effect of foot, restlessness and fever with thirst " is most significant.It diagnoses a disease experience for many years through the present inventor: " adenophora tetraphylla, Radix cynanchi wilfordii,
Lung spleen and a sick medicine ", has been put forward for the first time the new combination of two medicines.It is sweet natured, light, micro- that the present inventor is researched and proposed adenophora tetraphylla
Hardship, it is sweet can qi-restoratives, it is light can excreting dampness, it is bitter can eliminating dampness, it is sweet it is light be harmonious, the not only sorrow of helpless heresy, but also without the disadvantage hurt just.Its hardship is slight bitter,
Eliminating dampness is without dry negative blood.Radix cynanchi wilfordii digestion-promoting spleen-invigorating, the actual situation for adjusting spleen yin unbalance；Rhizoma pinellinae praeparata is eliminating dampness and eliminating phlegm, during stomach function regulating is wide, with moistening lung
The radix glycyrrhizae preparata of resolving sputum, tonifying spleen stomach function regulating matches, and cold temperature offsets, and nature and flavor are gentle, and in, scattered hold back is harmonious for qi-regulating, is formed and single drug
The combination that script effect is taken on an entirely new look, in qualitative analysis with high performance liquid chromatograph test adenophora tetraphylla, rhizoma pinellinae praeparata, Radix cynanchi wilfordii,
Decocting liquid after the combination of moxibustion Radix Glycyrrhizae four traditional Chinese medicine also creates the color of a large amount of new larger areas in addition to the chromatographic peak of original four traditional Chinese medicine
Spectral peak shows that four traditional Chinese medicine combination produces the chemical analysis of many new lives, is no longer that former four traditional Chinese medicine simple function is simple
Combination.Adenophora tetraphylla, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, moxibustion Radix Glycyrrhizae four traditional Chinese medicine combination after pharmacology efficiency be also no longer physics addition but
Have occurred the new method of chemical newborn qualitative change, the interpretation of the cause, onset and process of an illness for the chronic cough that hits, become many people be difficult to realize and elite combination, be this
Side obtains the important unique point of clinical special effect.Therefore, adenophora tetraphylla, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, moxibustion Radix Glycyrrhizae are main ingredient, become this hair
One of the technical characteristics of bright formula.
On the basis of main ingredient, then with Rhizoma Atractylodis Macrocephalae, Poria cocos, dried orange peel benefit spleen regulating the qi flowing in the channels, yin is held back in conjunction Radix Ophiopogonis, Schisandra chinensis moistening lung.Bitter apricot
Benevolence, campanulaceae a surname's drop phase factor, Radix Angelicae Sinensis, mulberry skin blood-nourishing wash phlegm, PERICARPIUM TRICHOSANTHIS relieving stuffiness of the chest by dispersing aggregation of pathogens, and cordate houttuynia is detoxified heat-clearing, and polygonum cuspidate leads to internal organs and rushes down spleen,
It gathers strengthening the spleen and reducing phlegm altogether, moisturizes the function of peaceful lung.Full side is novel rigorous, and intricately woven together, combination is dexterous, and hit the interpretation of the cause, onset and process of an illness, to many reasons
Caused chronic cough obvious effect.Cooperate conventional help spleen yin, dispel the wet comprehensive compatibility of spleen, it is more complete rigorous.To spleen
The chronic cough of empty weight in wet base there is the unexpected nature and flavor characteristic of ordinary person to learn from other's strong points to offset one's weaknesses, combine with the main ingredient of strong mutual assistance, through tight
The chemical combination collaboration of careful compatibility combines together, and forms the main ingredient characterized by integrally and with one for the monarch of monarch, completes
A kind of innovating on the basis of succession again, hundred effects of clinical implementation 100.It is a kind of be not found in historical records and special effect it is slow
Property the cough special thinking of diagnosis and treatment, be the novelty that has of the present invention, one of creative main feature.
To form Pharmaceutical Analysis: inventive formulation pharmic function passes through the combination of slight bitter slightly cold tepor and benefiting yin eliminating dampness, shape
Mend battle array at strong a surname, but, qi-regulating soothing the liver with pungent-warm open it is strongly fragrant supplemented by, major-minor resultant force.Adenophora tetraphylla, method half in inventive formulation
Summer, Radix cynanchi wilfordii, moxibustion Radix Glycyrrhizae main ingredient have symptomatic treatment in acute condition, simultaneous treatment of principal and subordinate symptoms, the ultimate effect for being intended to Zhi Genzhiben to chronic cough.So
And the dried orange peel as ministerial drug, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Ophiopogonis, Schisandra chinensis are the important drugs of sweet light real spleen, help spleen yin.As minister
After medicine assists preceding four tastes main ingredient, the variation of control effect and mechanism promotes effectiveness to increase suddenly once again.Shared with major-minor medicine, actual situation with control,
Attack it is evil do not hurt just, righting and attack heresy, highlight Chinese medicine and cure the disease and stay people, people-oriented feature, compared with prior art, the present invention
Beneficial effect be: to a variety of spleen deficiency weight in wet base type chronic coughs, there is unique curative effect.Though have publication number CN101138604A,
A small amount of a few taste medicines in inventive formulation have been used in the documents such as CN106266542A, CN108210623A, CN105770075A,
But its compatibility main ingredient is entirely different, and flavour of a drug sum is different, and diagnosis and treatment based on an overall analysis of the illness and the patient's condition is suited the medicine to the illness difference, it has been disclosed that document in there is no " deficiency of the spleen-yin "
Guidance of the theory to flavour of a drug compatibility, a monarch and his subjects left side for compatibility make principle method also differ widely with the present invention.The present invention spleen yin not
In the case where foot, not using the direct therapy of help spleen yin as main point of penetration, deficiency of spleen-YIN tonifying spleen-yin not instead of not first,
Evidence-based " here all things on earth is made without taking leave, raw without having, for without relying on, success is not occupied ", is classified as adjuvant for tonifying spleen-yin and releases, before being not only
People " kind tonifying yin person, must in treating YIN within YANG, negative positive liter and it is biochemical infinite, positive negative help and fountainhead is inexhaustible " flexible utilization, but
It is counter that efficacy of a drug obvious effect is helped to enhance because of " husband does not occupy only, is not go ", it enables the invention to produce for the chronic cough of the deficiency of the spleen-yin disease
The unimaginable therapeutic effect of business.This control effect and mechanism having in view of basic theory difference, produces sweet in other documents
The different effect of light combination, is the innovation to the prior art, has inspired significant curative effect, is the embodiment and again of novelty of the present invention
One of one technical characteristics.
The prescription of 16 taste Chinese medicines of the invention, reasonable compatibility, by the ingenious combination of monarch, adjuvant improves the function of main ingredient
Effect, main ingredient show the purpose of adjuvant；By mutually coordinated effect, the special efficacy of beneficial spleen and stomach, tonifying spleen cough-relieving is played altogether.Especially this hair
Bright adenophora tetraphylla, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, moxibustion Radix Glycyrrhizae main ingredient and the reasonable compatibility for helping adjuvant, promotes the performance of drug effect, and through creating
Property labour practice obtain and tired take the one of key factor of effect and major technique special with the invaluable experience and the present invention of tired effect
One of sign.We have filled up a blank of part pertinacious chronic cough special efficacy recipe.
Preparation process:
The present invention treat cough Chinese materia medica preparation the preparation method is as follows:
Acquisition, processing and the processing of medicinal material:.
Adenophora tetraphylla: spring, the excavation of two season of autumn, fibrous root is removed, is taken advantage of after washing and fresh scrapes off rough bark, cleaning, drying.Rhizome is removed, is washed
Only, it moisturizes, cuts sheet, it is dry.
Rhizoma pinellinae praeparata: it summer, the excavation of two season of autumn, cleans, removes crust and fibrous root, dry.The tuber of pinellia is taken, size is separated, uses water logging
Bubble, without the dry heart, takes out to interior；Another extracting liquorice is appropriate, adds water to cook secondary, and collecting decoction pours into the lime liquor made of suitable quantity of water
In, it stirs evenly, the above-mentioned tuber of pinellia being impregnated with is added, impregnate, daily stirring 12 times, and 12 or more immersion liquid pH value is kept, until section
Yellow homogeneous, mouth are tasted micro- when having numb feeling in the tongue, take out, clean, dry in the shade or dry to get.
Radix glycyrrhizae preparata: spring, the excavation of two season of autumn, fibrous root is removed, is dried.Impurity and silt are removed, cleans, cuts long section, it is dry.It takes
Licorice tablet is fried to yellow to buff according to bake with honey (general rule 0213), takes out, cool down when tack-free.
Radix cynanchi wilfordii: autumn adopts.Impurity is removed, is cleaned, is moisturized, cut sheet, it is dry.
Dried orange peel: harvesting ripe fruit strips pericarp, sun drying or low temperature drying.Impurity is removed, shower water moisturizes, chopping,
It dries in the shade.
Rhizoma Atractylodis Macrocephalae: excavation when winter inferior leads are withered and yellow, upper leaf becomes fragile removes silt, dries or dry, then remove fibrous root.
Net impurity is picked, is soaked in water, soaking time should suitably be grasped according to season, climate change and Rhizoma Atractylodis Macrocephalae size, be pulled out after bubble, be moistened
Thoroughly, it is sliced, dries.
Poria cocos: excavating more than 7 Septembers, remove silt after digging out, after banking up " sweating ", spread out and dry in the air to dry tack free, then
" sweating " is repeated several times to existing wrinkle, the big portion of internal moisture after scattering and disappearing, dries in the shade.Poria cocos is taken, is impregnated, cleans, is slightly steamed after profit,
Crust is pruned in time, cutting is blocking or cuts sheet, dries.
Radix Ophiopogonis: summer excavation is cleaned, is exposed to the sun, banks up repeatedly, until doing very likely, removes fibrous root, dry.Impurity is removed,
It cleans, moisturizes, draw down, it is dry.
Schisandra chinensis: picking when the fruit matures in the fall, dries or dries after steaming, and removes carpopodium and impurity.Remove impurity.Used time
It smashs to pieces.
Semen armeniacae amarae: summer harvests ripening fruits, removes pulp and nucleocapsid, takes out seed, dries.Used time smashs to pieces.
Campanulaceae: spring, the excavation of two season of autumn, cleaning, remove fibrous root, take advantage of it is fresh peel off crust or do not remove crust, it is dry.Except impurity elimination
Matter is cleaned, moisturizes, cut sheet, dry.
Mulberry skin: last years in autumn, which fall, excavates root before secondary spring is germinateed, and scrapes off yellowish-brown rough bark, longitudinally splits, strips root skin,
It dries.Grey bits are brushed away, is cleaned, is moisturized rear chopping, dry
Radix Angelicae Sinensis: the excavation of autumn end removes fibrous root and silt, after moisture slightly evaporates, is bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.
Impurity is removed, cleans, moisturizes, shave, sun drying or low temperature drying.
PERICARPIUM TRICHOSANTHIS: autumn harvesting ripe fruit is splitted, and is removed fruit flesh and seed, is dried in the shade.Impurity is removed, is eluted with water, is fished out
Out, slightly bored, chopping is dried, and the used time smashs to pieces.
Cordate houttuynia: fresh herb or dry aerial parts.Fresh goods whole year can tap；The luxuriant flower spike of dry product summer cauline leaf is more
When tap.Flavour amino acid removes impurity.Dry cordate houttuynia removes impurity, cleans rapidly, dissection, dry.
Polygonum cuspidate: spring, the excavation of two season of autumn, fibrous root is removed, is cleaned, is taken advantage of fresh-cut short section or sheet, dry.Impurity is removed, is cleaned,
It moisturizes, cuts sheet, it is dry.
Above-mentioned medicinal material is processed by Chinese Pharmacopoeia (annex) kind and is executed under item, supplementary material specification quality standard and reviewing party
Method should meet China's coastal port one regulation.
Its preparation of following dosage form is made in the Chinese medicine composition (hereinafter referred to as medicine group) that the present invention treats cough Chinese materia medica preparation
Method and process are as follows:.
Decoction:
(1) medicine group is mixed and is used as medicine group to be decocted；
(2) clear water that 2~4 times of the total deal of medicine group to be decocted is added for the first time is standing and soaking 20~35 points of kinds and decocts, and decocts after boiling
20~30 points of kinds, it is spare to filter out medical fluid；
(3) clear water that 3~5 times of the total deal of medicine group to be decocted is added for the second time decocts, and 30~40 points of kinds are decocted after boiling, filter out medical fluid
It is spare；
(4) clear water that 4~6 times of the total deal of medicine group to be decocted is added for the third time decocts, and 40~50 points of kinds are decocted after boiling, filter out medical fluid
It is spare；
(5) 5~8 hours are stood after mixing one, two, three spare medical fluid；
(6) medical fluid after standing is filtered out sediment (can reduce toxicity after filtering out the sediment of part alkaloids generation) is afterwards
Take decoction.
Pill:
(1) medicine group is ground into fine powder, medicinal powder is the sieving of 80~100 mesh, is mixed；
(2) every 40g refined honey add 40g water to be mixed into close aqueous mixtures spare, ball mould blank pill mould, every 100g fine powder blank pill
Mould 8g；
(3) refined honey aqueous mixtures in step (2) will be added in step (1) fine powder, every 100g fine powder adds 30~50g refined honey to prepare
Close aqueous mixtures, mix；
(4) general ball, dry to get pill, drying temperature is 80~90 DEG C.
Granule:
(1) taking the adenophora tetraphylla of half recipe quantity, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, moxibustion Radix Glycyrrhizae, Rhizoma Atractylodis Macrocephalae, Poria cocos to crush is 80~100 mesh
Sieving to obtain fine powder, it is spare；
(2) adenophora tetraphylla of remaining half recipe quantity, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, moxibustion Radix Glycyrrhizae, Rhizoma Atractylodis Macrocephalae, Poria cocos do not crush with other
The mixing of full recipe quantity flavour of a drug after decocted as medicine group to be decocted, the same decoction of decoction process (2) (3) (4) (5) (6) step；
(3) decocting liquid made from is evacuated to concentration and fills, and filtrate is concentrated into the clear cream (60 DEG C of temperature) that relative density is 1.25；
(4) by above-mentioned clear cream be added above-mentioned steps (1) fine powder and be added medicinal powder and clear cream total amount 0.5~1.5% Steviosin and
5~15% starch of medicinal powder and clear cream total amount mixes；
(5) granulator molding is added, particle is made, dry, for whole grain to get granule, drying temperature is 75~85 DEG C.
Oral solution:
(1) medicine group is mixed, carries out crushing the fine powder for the sieving of 40~60 mesh after mixing；
(2) the clear water medicine that step (1) fine powder raw material is added 3~5 times of raw material is decocted for the first time, will be decocted after decocting after forty minutes
Medical fluid filters out spare；
(3) second the clear water medicine that fine powder raw material after step (2) decoction is added 4~6 times of raw material is decocted, after sixty minutes will be decocted
Medical fluid filters out spare after decoction；
(4) sediment is filtered out after standing 4~6h after mixing step (2), the spare medical fluid of step (3), is evacuated in concentration tank；
(5) medical fluid in concentration tank is concentrated into relative density is 1.15, collects concentrate, it is spare to stand 5h；
(6) by the filtration of gained concentrate, it is filling be distributed into 50mL/ bottle, gland seals；
(7) medicine bottle of filling and sealing is packed into sterilizing cabinet, 120 DEG C of saturated vapors sterilize, cooling to get oral solution.
Capsule:
(1) medicine group is obtained into fine powder by aforementioned " granule " recipe step (1)；
(2) medicine group is obtained into the clear cream (60 DEG C of temperature) that relative density is 1.25 by aforementioned " granule " recipe step (2) (3)；
(3) drying of fine powder mixing granulation (temperature is 40~60 DEG C) is added in above-mentioned clear cream, heap is made in the sieving of 12~20 mesh of whole grain
Density >=1.25g/cm3Particle；
(4) above-mentioned particle feeding is entered into compressed particle machine, is 38000n~140000n model in the squeeze pressure of compressed particle machine
It encloses, capsule is made with conventional method.
Tablet:
(1) medicine group is obtained into fine powder by aforementioned " granule " recipe step (1)；
(2) medicine group is obtained into the clear cream (60 DEG C of temperature) that relative density is 1.25 by aforementioned " granule " recipe step (2) (3)；
(3) dry (temperature is 35-50 DEG C) a little is added after step (1) fine powder mixing granulation in above-mentioned clear cream, particle keeps micro-
Moisture content is measured convenient for compacting, whole grain crosses 10~18 meshes, and heap density >=0.80g/cm is made3Particle；
(4) weight calculation is re-fed into tablet press machine molding after lubricant being added in above-mentioned particle, up to the oral tablet of chewable tablets type after drying
Agent.
Powder:
(1) medicine group is mixed, is crushed after mixing；
(2) then powder is sieved is 100~120 targeted fine powders；
(3) quality testing will be carried out after fine powder divided dose, is finally packaged into powder.
The preparation process and step of above-mentioned treatment cough Chinese materia medica preparation must meet quality management system, and " drug is raw
Yield and quality management regulation " (Good Manufacture Practiceof Medical Products) standard and quality want
It asks.
Quality standard:
Quality standard is to control the foundation of this treatment cough Chinese materia medica preparation quality.It must be in strict accordance with " Chinese Pharmacopoeia 2005
One annex prescribed requirement of version, this treatment cough Chinese materia medica preparation is detected from all items such as preparation method, identification, inspection.It is reflecting
In other item using microscopic identification method, thin-layered chromatography, high performance liquid chromatography respectively in prescription adenophora tetraphylla, rhizoma pinellinae praeparata, every
Mountain sled, moxibustion Radix Glycyrrhizae, dried orange peel, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Ophiopogonis, Schisandra chinensis, semen armeniacae amarae, campanulaceae, mulberry skin, Radix Angelicae Sinensis, PERICARPIUM TRICHOSANTHIS, cordate houttuynia, tiger
Cane is identified, and is compareed with reference substance and negative sample；It, need to be to granularity, moisture, melting, loading amount under check item
Difference and limit test of microbe all take three batches of 9 samples to be detected respectively, and testing result is all in limits.Micro-
Under biological limit test item, methodology validation is carried out.Various detection methods and operating instruction strictly press national standard execution.
Patent medicine identifies:
Chinese materia medica preparation of the present invention is identified using following methods.
High performance liquid chromatography；
(1) instrument and reagent: U.S.'s Agilent1100 liquid chromatograph；Berberine hydrochloride reference substance (Chinese pharmaceutical biological product
Identify institute 110713-200208)；
(2) chromatographic condition: chromatographic column: Diamonsil C18(250 × 4.6mm) 4 μm；Mobile phase: the fine -0.033mol/l phosphorus of second
(2.0) 29:71 is with phosphoric acid regulating ph value to acid dihydride potassium solution；Flow velocity: 1mL min-1；Detection wavelength: for 370nm；
(3) preparation of reference substance solution: precision is weighed in dry 5 hours Berberine hydrochloride reference substances of 100oC, adds mobile phase system
Solution at every 1ml containing 0.1mg；
(4) range of linearity is tested: precision weighs Berberine hydrochloride reference substance 15.0mg, sets in 15ml measuring bottle, adds 1% hydrochloric acid methanol
Make to dissolve and be diluted to scale, precision measures 0.05ml, 0.1ml, 0.2ml, 0.4ml, 0.8ml, sets in 10ml measuring bottle, add respectively
1% hydrochloric acid methanol shakes up, filters, 10 μ l of subsequent filtrate is taken to inject liquid chromatograph, measurement is vertical sit with integrating peak areas to scale
It marks (Y), Berberine hydrochloride solution concentration is abscissa (X), acquires regression equation are as follows: Y=5x10-5, X-0.5225, R=
0.9999, conclusion shows: Berberine hydrochloride solution concentration sample introduction within the scope of 5.0~80.0 μ g/ml, peak area with it is corresponding
Solution concentration is in good linear relationship；
(5) it produces Chinese medicine preparation test sample injection liquid chromatograph and obtains chromatogram by guidelines.
Thin-layered chromatography:
Chinese materia medica preparation content of dispersion 10g of the present invention is taken, it is finely ground (except decoction and oral agents), add methanol 50ml, sets and heated back in water-bath
Stream 1 hour, lets cool, and filters, filtrate is as test solution.Control medicinal material 0.4g separately is taken, adds methanol 20ml, is made in the same way of control
Medicinal material solution.It is tested according to thin-layered chromatography, draws 5 μ l of test solution, 2 μ l of control medicinal material solution is put respectively in same silica gel
On G lamellae, with benzene-acetate-methanol-isopropanol -- strong ammonia solution (12:6:3:3:1) is solvent, and it is full to set ammonia steam
In the chromatography cylinder of sum (test of every taste medicinal material sampling should be met " Chinese Pharmacopoeia 2005 version regulation), expansion, taking-up is dried in the air
It is dry, it sets and is inspected under ultraviolet lamp (365nm).In sample chromatogram, on position corresponding with reference medicine chromatography figure, show identical
Yellow fluorescence spot.The test of every taste medicinal material should meet the related every rule of one annex of China's coastal port in patent medicine
It is fixed.
Microscopic identification method:
Chinese materia medica preparation of the present invention is taken, microscopically observation is set: every taste medicinal material detects under the microscope in patent medicine trichome, born of the same parents
The features such as wall, cell, epidermis, cell dia, type shape, pigment, cluster crystal, tissue space should meet China's coastal port one
Related every regulation.
Moisture content leaches quality standard and inspection；
(1) moisture content, specific method and parameter request are surveyed with rapid moisture analyzer before finished dosage form (removing decoction, oral solution) packing
Photograph answers moisture content limitation under dosage form item to refer to calibration method regulation (one I A of annex of China's coastal port) and " checked operation
Regulation general rule ".
(2) time limit, specific method and parameter are leached with disintegration time mensuration instrument measurement finished dosage form (removing decoction, oral solution)
It is required that providing (one I A of annex of China's coastal port) according to the method under the corresponding dosage form item of disintegration time mensuration method.
Stability experiment:
According to " two annex of Chinese Pharmacopoeia 2005 version " medicine stability test guideline ", combined treatment cough Chinese medicine
The characteristics of preparation, accelerate stability inspection item being determined as appearance type shape, thin-layer chromatography reflects in chronic test
Not, water content inspection, limit test of microbe check the stability of Chinese medicine preparation result with this.
(1)Influence factor test: using medical polypropylene composite film packaging (removing decoction), in temperature (60 DEG C), humidity
(90% ± 5%, 25 DEG C) was placed 10 days under conditions of Qiang Guang (5000I ×), and respectively at 5 days, 10 days sample detections.Influence because
Plain test result: its type shape, chromatography mirror after this product is placed 10 days in the case of temperature (60 DEG C), humidity (95% ± 5%, 25 DEG C)
Not, moisture, microbial limit meet regulation, stable product quality.
(2)Accelerated test: using medical polypropylene composite film packaging (removing decoction), in temperature (40 DEG C ± 2 DEG C), humidity
It is placed 6 months under conditions of (75% ± 5%), respectively at 0,1,2,3,6 month sample detection.As a result: accelerated test 6 months,
Type shape, chromatographic identification, moisture, the microbial limit of sample meet regulation, stable product quality.
(3)The chronic test that keeps sample: it is wet at temperature (25 DEG C ± 2 DEG C) using medical polypropylene composite film packaging (removing decoction)
It is placed 12 months under conditions of degree (60% ± 10%).Respectively at 0,3,6,12 month sample detection.As a result: through chronic test 12
Month the result shows that, type shape, chromatographic identification, moisture, microbial limit meet regulation, stable product quality.
Stability test result is；It is investigated by 6 months accelerated tests, indices are basically unchanged.Chronic test 12
Show that indices are without significant change within a month.According to accelerated test and chronic stable test result, will tentatively be set to validity period
12 months.
Anxious poison experiment:
Treatment cough Chinese materia medica preparation of the invention is administered to intragastric administration on mice, observes 7 days, to LD50 > 25.0g/kg of mouse, is
90 times or more (adult clinic recommended dose 0.25g/kg) of clinical recommended dose, mouse is with 45.0g/kg, volume 30ml/kg
Stomach-filling, freely, appearance activity is reduced after 12 hours for test mice activity after administration, all real without 1 dead mouse after 12 hours
It tests mouse hair and is close to body, glossy, diet, excrement and other situations are without exception.Animal subject weight has increase after 7 days.
According to clinical observation result and anxious malicious experimental result, it was demonstrated that the drug quality is safe.
Treatment method:
Usage and dosage: the content of dispersion criterion calculation that each dosage form (except decoction is followed the doctor's advice) is detected by molding inner wrapping；Illness is pressed every time
Situation takes 5~8 grams of content of dispersion of patent medicine, three times a day；
Avoid raw, cold, pungent, peppery, avoids tobacco and wine, pregnant woman is used with caution.
Example scheme:
The present embodiment uses the cough patient that different parts by weight formula and dosage form are suitable for different symptoms.
Embodiment 1: the dosage form that the present embodiment treats cough is decoction, is made of the traditional Chinese medicinal components of following parts by weight: south
48 parts of the root of straight ladybell, 24 parts of rhizoma pinellinae praeparata, 26 parts of moxibustion Radix Glycyrrhizae, 24 parts of Radix cynanchi wilfordii, 20 parts of dried orange peel, 36 parts of Rhizoma Atractylodis Macrocephalae, 24 parts of Poria cocos, Radix Ophiopogonis 36
Part, 12 parts of Schisandra chinensis, 24 parts of semen armeniacae amarae, 27 parts of campanulaceae, 20 parts of mulberry skin, 24 parts of Radix Angelicae Sinensis, 36 parts of PERICARPIUM TRICHOSANTHIS, 72 parts of cordate houttuynia, tiger
61 parts of cane；
The preparation method and processing step of 1 decoction of embodiment are the same as aforementioned " decoction preparation method in preparation process ".
Embodiment 2: the dosage form that the present embodiment treats cough is tablet, is made of the traditional Chinese medicinal components of following parts by weight: south
68 parts of the root of straight ladybell, 34 parts of rhizoma pinellinae praeparata, 36 parts of moxibustion Radix Glycyrrhizae, 34 parts of Radix cynanchi wilfordii, 29 parts of dried orange peel, 51 parts of Rhizoma Atractylodis Macrocephalae, 34 parts of Poria cocos, Radix Ophiopogonis 51
Part, 17 parts of Schisandra chinensis, 34 parts of semen armeniacae amarae, 38 parts of campanulaceae, 29 parts of mulberry skin, 34 parts of Radix Angelicae Sinensis, 51 parts of PERICARPIUM TRICHOSANTHIS, 101 parts of cordate houttuynia, tiger
86 parts of cane；
The preparation method and processing step of 2 tablet of embodiment are the same as aforementioned " tablet preparation method in preparation process ".
Embodiment 3: the dosage form that the present embodiment treats cough is granule, is made of the traditional Chinese medicinal components of following parts by weight:
31 parts of adenophora tetraphylla, 16 parts of rhizoma pinellinae praeparata, 17 parts of moxibustion Radix Glycyrrhizae, 16 parts of Radix cynanchi wilfordii, 13 parts of dried orange peel, 23 parts of Rhizoma Atractylodis Macrocephalae, 16 parts of Poria cocos, Radix Ophiopogonis 23
Part, 8 parts of Schisandra chinensis, 16 parts of semen armeniacae amarae, 17 parts of campanulaceae, 13 parts of mulberry skin, 16 parts of Radix Angelicae Sinensis, 23 parts of PERICARPIUM TRICHOSANTHIS, 47 parts of cordate houttuynia, polygonum cuspidate
40 parts；
The preparation method and processing step of 3 granule of embodiment are the same as aforementioned " granule preparation method in preparation process ".
Efficacy assessment standard:
Evaluation criteria uses four kinds of efficacy results；
Cure: cough symptom disappear, appetite enhancing, stomach is unobstructed, no cough symptom, more after do not recur；
Effective: cough symptom is obviously improved, and appetite enhancing, stomach is unobstructed, without obvious cough symptom；
Effective: cough symptom improves, and stomach is unobstructed, and cough symptom is alleviated；
Invalid: cough symptom is without improvement, without significant change before cough symptom and medication.
Observation of curative effect:
Observation of curative effect uses common chuanbei pipa syrup and compares.
Observe the beneficial effect of this preparation compared with prior art using treatment cough granule of the invention, the present invention
Preparation (granule being formulated using previous embodiment 3) is compared observation with the curative effect of chuanbei pipa syrup treatment cough.
Method are as follows: see and treat patients 412 cough patients are randomly divided into treatment group and control group, treatment group 207 takes orally the present invention
Granule (adult three times per day, each 8g, 7~10 days as one therapeutic course)；Control group 205, oral chuanbei pipa syrup (abides by it
Product description administration), observe the treatment results situation of cough patient；
It is as a result as follows after 1~2 course of therapy:
| Group | It cures | Effectively | It is effective | It is total effective | In vain | It is efficient |
| Treatment group (207) | 173 | 18 | 8 | 199 | 8 | 96.1% |
| Control group (205) | 123 | 35 | 15 | 173 | 32 | 84.4% |
Treatment group and control group effective percentage are respectively 96.1% and 84.4%, examine correlation statistics function through statistical calculations.
Comparison among groups two groups of means the statistics t inspection in Excel, X2It examines.Verify P value；
The P value that Chitest [ parameter 1, parameter 2 ] is calculated:
P value=Chitest (x:y, d1:d2)=0.00005676；
X=treatment group's significant figure；
Y=control group invalid number；
D1=theoretical value (treatment group's sum × two groups of effectively total/two groups of sums)；
D2=theoretical value (control group sum × two groups of invalid sums/two groups of sums)；
Use X2The P value of the ending probability inspection of distribution:
Chidist [ X2The P value (parameter 1, parameter 2) of inspection ]:
P value=Chidist (x, y)=0.00005676；
X=(treatment group's significant figure × control group invalid number-control group significant figure × treatment group's invalid number)2× two groups of sum/(two
Group effectively sum × two groups of invalid sums × treatment group's sum × control group sum);
y=1。
It is P < 0.01 through two kinds of statistical calculations results, display medicine observation of curative effect comparing result has significant difference.
Conclusion: the present invention, which treats cough patient, significant curative effect.It is clinical it is nearly more than 40 years in use, up to now not yet
It was found that an example is due to taking adverse reaction caused by present invention treatment cough preparation, it was demonstrated that the present invention treats cough Chinese medicine
Preparation is safe and effective when regular dose treatment is taken, and toxic side effect is low.In chronic large dose oral administration, no malaise symptoms, evil
The heart has no adverse reaction.
Be by beneficial effect caused by observation of curative effect Chinese materia medica preparation of the invention: various medicinal material compatibilities, which have, mutually benefits
The effect of evident, is increased and decreased adjustment to the parameter of formula for all kinds of cough illnesss, is caused with being suitable for the diseases such as spleen deficiency weight in wet base
Cough illness, good effect of the present invention, toxic side effect are small, and securely and reliably, preparation method is scientific and reasonable.
Typical clinical case:
Typical clinical case is the sufferer in recent years randomly selected.
Case 1: all XX, male, 59 years old, Sichuan Province people from Leshan: first visit date: 2014.10.15.Cough 40 years.The long-term heart
Tired shortness of breath.Patient mental is depressed, asthma uncomfortable in chest, dynamic then cough, and night is more severe, very when round the clock must not sleeping, once with a variety of
Chinese medicine and western medicine treatment, poor effect.It is self-degradation later, it is again not in hospital.Because chronic cough very early cannot
Work, gets worse recently, is that layman accompanies lower active medical.It examines and sees that paroxysmal spasmodic cough is frequent, apathetic, lusterless complexion, body
Syntexis, skin is dry and astringent, and white and greasy fur, pulse condition carefully delays.Print is examined: chronic cough.Prescription: 15 doses of Chinese medicine of the present invention.After half a month, symptom
Significant to mitigate, continual cure April, symptom all disappears.Thereafter body is gradually recovered.Annual after treatment 2 months later.2019
Follow-up on the 3rd in 2 months is significantly improved with the quality of life of family in person without recurrence over 5 years.
Case 2: old XX, male, 15 years old, the first Middle School Students of Sichuan Province Leshan: first visit date: 2014.11.02.Cough frequency
Hair 3 years, heated all multiple work of suffering from cold.Parent believes " child's cough is normal phenomenon, in a few years can spontaneous recovery ", still without timely
It is medical.It acutely coughs in school sessions afterwards, influences classroom discipline, cause teacher to pay close attention to and be concerned about, it is proposed that it is medical, it is diagnosed as chronic
It coughs (Bronchopneumonia).Chinese materia medica preparation January of the present invention is taken, symptom significantly mitigates.Treatment 2 months is continued to strengthen, cough is all
It eliminates.Follow-up on December 12 in 2018: 5 years so far without recurrence.
Case 3: enemy X, female, 48 years old, Sichuan Province Zigong City people: the first visit date: 2016.07.09 took very 2 years when cough
A variety of drug therapies are crossed, unsatisfactory curative effect is examined through friend's introduction.After taking Chinese materia medica preparation January of the present invention, cough is clearly better,
Continue to take Chinese materia medica preparation half a month of the present invention, cough disappears, and follow-up is without recurrence after 3 years.
Case 4: thanking to X, and female, 32 years old, Meishan people from city: the first visit date: 2016.11.14. cough, shortness of breath exceeded 3 years,
Self-induction constitution is very poor, the more whirlpool phlegm of dreaminess, and food is peppery, coughs more very.Pink tongue thin white fur of tongue is greasy.Hepatitis B medical history.Multiple hospitals are medical
Conscious curative effect is not good enough, tosses about to be diagnosed as chronic cough to examine.Chinese materia medica preparation January of the present invention is taken, above-mentioned symptom is substantially reduced,
Continue symptom after taking 1 month to disappear, continues to strengthen treatment January.Follow-up 3 years without recurrence.
Treatment results:
The statistics for the treatment of results has taken the part statistical data for curing patient in recent years；
Patient's examples up to ten thousand have been cured in the late four decades, have been calculated according to 3316 patients that statistics part is accepted for medical treatment in recent years, through two
A course of therapy, wherein curing 2082, effective 739, effective 391, invalid 104, total effective rate is up to 97.1%.This system
It counts and statistical result only is paid a return visit to part patient in recent years, the cough sufferer cured for many years has case history preservation,
The patient data of healing is far longer than the statistical data.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
The change or replacement expected without creative work, should be covered by the protection scope of the present invention.
Claims (8)
1. a kind of Chinese materia medica preparation for treating cough, which is characterized in that be by adenophora tetraphylla, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, moxibustion Radix Glycyrrhizae, old
Skin, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Ophiopogonis, Schisandra chinensis, semen armeniacae amarae, campanulaceae, mulberry skin, Radix Angelicae Sinensis, PERICARPIUM TRICHOSANTHIS, cordate houttuynia, 16 taste Chinese medicinal composition of polygonum cuspidate
Chinese medicine composition, be made of the traditional Chinese medicinal components of following parts by weight: 88~16 parts of adenophora tetraphylla, 44~8 parts of rhizoma pinellinae praeparata, Radix cynanchi wilfordii 44
~8 parts, 48~8 parts of moxibustion Radix Glycyrrhizae, 37~7 parts of dried orange peel, 66~12 parts of Rhizoma Atractylodis Macrocephalae, 44~8 parts of Poria cocos, 66~12 parts of Radix Ophiopogonis, Schisandra chinensis
22~4 parts, 44~8 parts of semen armeniacae amarae, 49~9 parts of campanulaceae, 37~7 parts of mulberry skin, 44~8 parts of Radix Angelicae Sinensis, 66~12 parts of PERICARPIUM TRICHOSANTHIS, fish raw meat
133~23 parts, 112~20 parts of polygonum cuspidate of grass.
2. a kind of Chinese materia medica preparation for treating cough according to claim 1, which is characterized in that by following parts by weight
Medicine group is grouped as: 78~36 parts of adenophora tetraphylla, 39~18 parts of rhizoma pinellinae praeparata, 39~18 parts of Radix cynanchi wilfordii, 42~20 parts of moxibustion Radix Glycyrrhizae, dried orange peel 33
~15 parts, 59~27 parts of Rhizoma Atractylodis Macrocephalae, 39~18 parts of Poria cocos, 59~27 parts of Radix Ophiopogonis, 20~9 parts of Schisandra chinensis, 39~18 parts of semen armeniacae amarae, tangerine
44~20 parts of stalk, 33~15 parts of mulberry skin, 39~18 parts of Radix Angelicae Sinensis, 59~27 parts of PERICARPIUM TRICHOSANTHIS, 117~55 parts of cordate houttuynia, polygonum cuspidate 99~
46 parts.
3. a kind of Chinese materia medica preparation for treating cough according to claim 1, which is characterized in that by following parts by weight
Medicine group is grouped as: 57~23 parts of adenophora tetraphylla, 29~12 parts of rhizoma pinellinae praeparata, 29~12 parts of Radix cynanchi wilfordii, 31~13 parts of moxibustion Radix Glycyrrhizae, dried orange peel 24
~10 parts, 43~18 parts of Rhizoma Atractylodis Macrocephalae, 29~12 parts of Poria cocos, 43~18 parts of Radix Ophiopogonis, 14~6 parts of Schisandra chinensis, 29~12 parts of semen armeniacae amarae, tangerine
Obstruct 32~13 parts, 24~10 parts of mulberry skin, 29~12 parts of Radix Angelicae Sinensis, 43~18 parts of PERICARPIUM TRICHOSANTHIS, 86~35 parts of cordate houttuynia, polygonum cuspidate 73~30
Part.
4. a kind of Chinese materia medica preparation for treating cough according to claim 1, which is characterized in that by following parts by weight
Medicine group is grouped as；68 parts of adenophora tetraphylla, 34 parts of rhizoma pinellinae praeparata, 34 parts of Radix cynanchi wilfordii, 36 parts of moxibustion Radix Glycyrrhizae, 29 parts of dried orange peel, 51 parts of Rhizoma Atractylodis Macrocephalae, Poria cocos
34 parts, 51 parts of Radix Ophiopogonis, 17 parts of Schisandra chinensis, 34 parts of semen armeniacae amarae, 38 parts of campanulaceae, 29 parts of mulberry skin, 34 parts of Radix Angelicae Sinensis, 51 parts of PERICARPIUM TRICHOSANTHIS, fish
101 parts, 86 parts of polygonum cuspidate of raw meat grass.
5. a kind of Chinese materia medica preparation for treating cough according to claim 1, which is characterized in that by following parts by weight
Medicine group is grouped as；48 parts of adenophora tetraphylla, 24 parts of rhizoma pinellinae praeparata, 24 parts of Radix cynanchi wilfordii, 26 parts of moxibustion Radix Glycyrrhizae, 20 parts of dried orange peel, 36 parts of Rhizoma Atractylodis Macrocephalae, Poria cocos
24 parts, 36 parts of Radix Ophiopogonis, 12 parts of Schisandra chinensis, 24 parts of semen armeniacae amarae, 27 parts of campanulaceae, 20 parts of mulberry skin, 24 parts of Radix Angelicae Sinensis, 36 parts of PERICARPIUM TRICHOSANTHIS, fish
72 parts, 61 parts of polygonum cuspidate of raw meat grass.
6. a kind of Chinese materia medica preparation for treating cough according to claim 1, which is characterized in that by following parts by weight
Medicine group is grouped as；31 parts of adenophora tetraphylla, 16 parts of rhizoma pinellinae praeparata, 16 parts of Radix cynanchi wilfordii, 17 parts of moxibustion Radix Glycyrrhizae, 13 parts of dried orange peel, 23 parts of Rhizoma Atractylodis Macrocephalae, Poria cocos
16 parts, 23 parts of Radix Ophiopogonis, 8 parts of Schisandra chinensis, 16 parts of semen armeniacae amarae, 17 parts of campanulaceae, 13 parts of mulberry skin, 16 parts of Radix Angelicae Sinensis, 23 parts of PERICARPIUM TRICHOSANTHIS, fish raw meat
47 parts, 40 parts of polygonum cuspidate of grass.
7. according to claim 1 to the Chinese materia medica preparation of any treatment cough described in 6, which is characterized in that in Chinese materia medica preparation
The main ingredient of compatibility are as follows: adenophora tetraphylla, rhizoma pinellinae praeparata, Radix cynanchi wilfordii, moxibustion Radix Glycyrrhizae.
8. according to claim 1 to the Chinese materia medica preparation of any treatment cough described in 6, which is characterized in that the Chinese materia medica preparation
Dosage form be decoction, granule, pill, capsule, tablet, powder, oral solution.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109432345A (en) * | 2018-12-21 | 2019-03-08 | 四川维杏生物科技有限公司 | It is a kind of to treat diarrheal disease Chinese materia medica preparation and preparation method |
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| US20160375084A1 (en) * | 2015-06-29 | 2016-12-29 | Infinitus (China) Company Ltd. | Traditional chinese medicine composition and the use thereof |
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| US20160375084A1 (en) * | 2015-06-29 | 2016-12-29 | Infinitus (China) Company Ltd. | Traditional chinese medicine composition and the use thereof |
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| 刘利华 等: "当归治咳喘", 《吉林中医药》 * |
| 熊维镁 等: "治疗虚实夹杂型咳嗽的体会", 《湖北中医杂志》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109432345A (en) * | 2018-12-21 | 2019-03-08 | 四川维杏生物科技有限公司 | It is a kind of to treat diarrheal disease Chinese materia medica preparation and preparation method |
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