CN109846770A - It is a kind of to have effects that slow down plant extract composition of skin irritatin and preparation method thereof, application - Google Patents
It is a kind of to have effects that slow down plant extract composition of skin irritatin and preparation method thereof, application Download PDFInfo
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Abstract
The present invention relates to plant society field of pharmaceutical chemistry technology, more particularly to a kind of have effects that slow down plant extract composition of skin irritatin and preparation method thereof, application, it is described to have effects that the plant extract composition for slowing down skin irritatin is grouped as by the group of following parts by weight: 10~40 parts of stephania tetrandra extract, Honegsukle flower P.E 10~80 and 10~40 parts of coptis extract.Plant extract composition provided by the invention can effectively improve the cell viability of epidermal cell, improve skin barrier function；Inhibit the expression of macrophage inflammatory factor, it can anti-inflammatory significant effect.The plant extract composition is a kind of pure plant raw material with alleviation skin irritatin.
Description
Technical field
The present invention relates to plant society field of pharmaceutical chemistry technology more particularly to a kind of have effects that slow down skin irritatin
Plant extract composition and its application.
Background technique
With the improvement of people's living standards, necessity of the cosmetics and skincare product as daily life, type gradually increase, use
Amount also increases year by year.However the cosmetics safety event produced repeatedly in recent years, stimulation problem of the cosmetics to skin is highlighted
Come.National correlation department increasingly payes attention to consumer safety, and consumer is also increasing the cognition of product safety, matchmaker
Body is promoting the attention rate of cosmetics safety, and this requires Management of Cosmetics Enterprises more to pay attention to the safety of product.Produce peace
Entirely, mildly, low stimulation, the cosmetics without sensitization source be increasingly becoming the benchmark and common recognition of each large enterprises.In this context, it develops
The cosmetic material to skin irritatin can effectively be slowed down, it will the welcome by business and consumer.Chinese medicine has 2,000 in China
The usage history of many years, most of is the higher natural plants of safety, found from Chinese medicine have slow down skin irritatin at
Dividing is a popular domain.
Summary of the invention
In order to overcome the above-mentioned problems of the prior art, provide a kind of has effects that slow down skin irritatin the present invention
Plant extract composition.
The present invention also provides a kind of preparation methods of plant extract composition for having effects that slow down skin irritatin.
The present invention also provides have effects that the plant extract composition for slowing down skin irritatin in cosmetics and external-use skin care
Application in preparation.
To achieve the goals above, the invention adopts the following technical scheme:
A kind of plant extract composition for having effects that slow down skin irritatin, it is described to have effects that the plant for slowing down skin irritatin mentions
Composition is taken to be grouped as by the group of following parts by weight: 10~40 parts of stephania tetrandra extract, Honegsukle flower P.E 10~80 and the coptis
10~40 parts of extract.
The present invention selects honeysuckle, the coptis and Fourstamen Stephania Root Chinese herbal medicine to retain original effect using traditional extraction and separation technology
Ingredient, being made has effects that slow down the plant extract composition of skin irritatin, and provides contain the plant extract composition simultaneously
Cosmetics or other external-use skin care preparations.The pharmacology of each component is as follows: honeysuckle: (1) it is cold in nature, it is sweet in flavor, have it is clearing heat and detoxicating,
Anti-inflammatory, qi-restoratives treats the effect of wind；(2) modern study proves that, a variety of pharmacological components such as chlorogenic acid that honeysuckle contains, thin
The versatiles such as bacterium viral inflammation, fever strengthen immunity, anti-inflammatory, antipyretic are extensive.The coptis: there are heat-clearing and damp-drying drug, purging intense heat solution
The effect of malicious；Containing composition of alkaloids such as jamaicin, coptisine, epiberberines, there is the work such as antibacterial, antiviral, anti-inflammatory, anti diar rhea
With.Fourstamen Stephania Root: bitterly, cold in nature, the alkaloid containing there are many has the effect of inducing diuresis for removing edema, wind-expelling pain-stopping.
Preferably, tetrandrine contains in the stephania tetrandra extract on the basis of single plant extracts gross mass
Amount is 10 ~ 98wt%, and the content of the Honegsukle flower P.E Content of Chlorogenic Acid is 10 ~ 98wt%, and hydrochloric acid is small in the coptis extract
The content of bark of a cork tree alkali is 10 ~ 98wt%.
A kind of preparation method for the plant extract composition for having effects that slow down skin irritatin, comprising the following steps:
(1) raw material is weighed according to following weight: 10~40 parts of Fourstamen Stephania Root, 10~80 parts of honeysuckle and the coptis 10~40
Part, it is cleaned with deionized water, and dry；
(2) raw material after drying in step (1) is separately or concurrently crushed, squeezes out liquid；
(3) liquid that step (2) obtain is filtered, obtains extracting solution；
(4) preservative is added in the extracting solution that step (3) obtain, stirs evenly to get having effects that slow down skin irritatin
Plant extract composition.
Have effects that application of the plant extract composition for slowing down skin irritatin in cosmetics and external-use skin care preparation.
The surfactants bring skin irritatin such as SLS can be effectively relieved in plant extract composition provided by the invention,
And have stronger anti-inflammatory effect, be a kind of pure natural cosmetics anti-irritant raw material, can be used for being added to a variety of cosmetics and
In other external-use skin care preparations.
A kind of external-use skin care preparation for having effects that slow down skin irritatin, to have effects that the external application shield for slowing down skin irritatin
On the basis of formulations for skin gross mass, it is described have effects that slow down in the external-use skin care preparation of skin irritatin containing 1 ~ 8wt% have subtract
The plant extract composition of slow skin irritatin effect.
Preferably, the external-use skin care preparation is facial cleanser, face cream, facial mask, Essence, toner, lotion or aqua.
According to using approach different, plant extract composition provided by the invention is and unlimited as external-use skin care preparation made of raw material
In lotion, it can also be fabricated to facial cleanser, face cream, facial mask, Essence, toner etc..It can be according to known in skin care industry field
Method, a variety of different external-use skin care preparations are made in above-mentioned plant extract composition.
A kind of lotion for having effects that slow down skin irritatin, to have effects that the lotion gross mass for slowing down skin irritatin as base
Standard, described to have effects that the lotion for slowing down skin irritatin is made of the raw material of following mass percentage:
A phase raw material: EDTA-2Na 0.1~0.3%, Kappa mother 0.2~1%, glycerol 1~5%, panthenol 0.1~1%, trehalose 1~
2%, 1,3-BDO 2~4% has effects that the plant extract composition 1~8% for slowing down skin irritatin, water 60~80%；
B phase raw material: PEG-100 stearate 1~3%, cetostearyl alcohol 0.5~1.5%, tristerin 0.5~1% gather different
Butylene 2~7%, caprylic capric glyceryl ester 1~5%, Butyrospermum parkii 0.5~3%, isohexadecane 2~7%；
C phase raw material: 10%NaOH 0.4~2.5%, preservative 0.1~0.2%.
Preferably, it is described have effects that slow down in the lotion of skin irritatin containing 1 ~ 5wt% have slow down skin irritatin
The plant extract composition of effect.
A kind of preparation method for the lotion for having effects that slow down skin irritatin, comprising the following steps:
(1) it adds water in kettle, Kappa mother is added, impregnates 10min, heating stirring is whole to raw material at a temperature of 80~85 DEG C
Dissolution is complete；
(2) A phase raw material is continuously added, keeping the temperature 80~85 DEG C of stirrings, all dissolution completely, obtains after heat preservation 10min sterilizing to raw material
A phase feedstock processing object is kept the temperature spare；
(3) B phase raw material is added in oily phase pot, 80~85 DEG C of agitating and heating dissolutions completely, are kept the temperature spare；
(4) A phase feedstock processing object obtained in step (2) is pumped into emulsion pot, B phase raw material is pumped into cream under homogeneous stirring
Change in pot, homogeneous 5min, starts to cool down after stirring heat preservation 10min；
(5) when temperature drops to 40~45 DEG C, in emulsion pot be added C phase raw material, discharge after mixing evenly, obtain have subtract
The lotion of slow skin irritatin effect.
Therefore, the invention has the following beneficial effects: plant extract composition provided by the invention, it can effectively improve table
The cell viability of chrotoplast improves skin barrier function；Inhibit the expression of macrophage inflammatory factor, antiphlogistic effects are significant.It should
Plant extract composition is a kind of pure plant raw material with alleviation skin irritatin, can according to using approach different
It is not limited to lotion or aqua for being added in a variety of cosmetics, skin care item and other external-use skin care preparations, can be also fabricated to
Facial cleanser, face cream, facial mask, Essence, toner, skin cream etc..Can be according to known method in skin care industry field, it will be upper
It states plant extract composition and is made a variety of different external preparations, application range and its wide.
Detailed description of the invention:
Fig. 1 is that the present invention has effects that the plant extract composition for slowing down skin irritatin cell viability on HaCat cell model
The effect of evaluation result figure.
Fig. 2 is that the present invention has effects that the plant extract composition for slowing down skin irritatin in macrophage Raw264.7 model
The evaluation result figure of upper anti-inflammatory efficacy (PGE2).
Specific embodiment
Below by specific embodiment, the technical solutions of the present invention will be further described.
In the present invention, if not refering in particular to, all devices and raw material is commercially available or the industry is common are following
Method in embodiment is unless otherwise instructed conventional method in that art.
Embodiment 1
A kind of preparation method for the plant extract composition for having effects that slow down skin irritatin, comprising the following steps:
(1) raw material is weighed according to following weight: Fourstamen Stephania Root 10g, 10g parts of honeysuckle and coptis 10g are clear with deionized water
It washes, and dries；
(2) it by the raw material after being dried in step (1) while crushing, squeezes out liquid；
(3) liquid that step (2) obtain is filtered, obtains extracting solution；
(4) preservative is added in the extracting solution that step (3) obtain, stirs evenly to get stephania tetrandra extract, honeysuckle is contained
The plant extract composition slow down with skin irritatin of extract and coptis extract.
Wherein, on the basis of single plant extracts gross mass, the content of tetrandrine is in stephania tetrandra extract
10wt%, the content of Honegsukle flower P.E Content of Chlorogenic Acid are 10wt%, and the content of Berberine hydrochloride is 10wt% in coptis extract.
A kind of preparation method for the lotion for having effects that slow down skin irritatin, comprising the following steps:
(1) it adds water in kettle, Kappa mother is added, impregnates 10min, heating stirring is all dissolved to raw material at a temperature of 80 DEG C
Completely；
(2) A phase raw material is continuously added, keeping the temperature 80 DEG C of stirrings, all dissolution completely, obtains A phase after heat preservation 10min sterilizing to raw material
Feedstock processing object is kept the temperature spare；A phase raw material: EDTA-2Na 0.1%, Kappa mother 0.2%, glycerol 1%, panthenol 0.1%, trehalose
1%, 1,3-BDO 2% has effects that the plant extract composition 1% for slowing down skin irritatin, and surplus is water；
(3) B phase raw material is added in oily phase pot, 80~85 DEG C of agitating and heating dissolutions completely, are kept the temperature spare；B phase raw material: PEG-
100 stearates 1%, cetostearyl alcohol 0.5%, tristerin 0.5%, polyisobutene 2%, caprylic capric glyceryl ester 1%,
Butyrospermum parkii 0.5%, isohexadecane 2%；
(4) A phase feedstock processing object obtained in step (2) is pumped into emulsion pot, B phase raw material is pumped into cream under homogeneous stirring
Change in pot, homogeneous 5min, starts to cool down after stirring heat preservation 10min；
(5) when temperature drops to 40 DEG C, C phase raw material is added in emulsion pot, discharges after mixing evenly, C phase raw material: 10%NaOH
0.4%, preservative 0.1% obtains the lotion slow down with skin irritatin.
Embodiment 2
A kind of preparation method for the plant extract composition for having effects that slow down skin irritatin, comprising the following steps:
(1) raw material is weighed according to following weight: Fourstamen Stephania Root 40g, honeysuckle 80g and coptis 40g are clear with deionized water
It washes, and dries；
(2) raw material after drying in step (1) is crushed respectively, squeezes out liquid；
(3) liquid that step (2) obtain is filtered, obtains extracting solution；
(4) preservative is added in the extracting solution that step (3) obtain, stirs evenly to get stephania tetrandra extract, honeysuckle is contained
The plant extract composition slow down with skin irritatin of extract and coptis extract,.
Wherein, on the basis of single plant extracts gross mass, the content of tetrandrine is in stephania tetrandra extract
98wt%, the content of Honegsukle flower P.E Content of Chlorogenic Acid are 98wt%, and the content of Berberine hydrochloride is 98wt% in coptis extract.
A kind of preparation method for the lotion for having effects that slow down skin irritatin, comprising the following steps:
(1) it adds water in kettle, Kappa mother is added, impregnates 10min, heating stirring is all dissolved to raw material at a temperature of 85 DEG C
Completely；
(2) A phase raw material is continuously added, keeping the temperature 85 DEG C of stirrings, all dissolution completely, obtains A phase after heat preservation 10min sterilizing to raw material
Feedstock processing object is kept the temperature spare；A phase raw material: EDTA-2Na 0.3%, Kappa mother 1%, glycerol 5%, panthenol 1%, trehalose 2%, 1,
3- butanediol 4%, has effects that the plant extract composition 5% for slowing down skin irritatin, and surplus is water；
(3) B phase raw material is added in oily phase pot, 85 DEG C of agitating and heating dissolutions completely, are kept the temperature spare；B phase raw material: PEG-100 is hard
Resin acid ester 3%, cetostearyl alcohol 1.5%, tristerin 1%, polyisobutene 7%, caprylic capric glyceryl ester 5%, Butyrospermum parkii
3%, isohexadecane 7%；
(4) A phase feedstock processing object obtained in step (2) is pumped into emulsion pot, B phase raw material is pumped into cream under homogeneous stirring
Change in pot, homogeneous 5min, starts to cool down after stirring heat preservation 10min；；
(5) when temperature drops to 45 DEG C, C phase raw material is added in emulsion pot, discharges after mixing evenly, C phase raw material: 10%NaOH
2.5%, preservative 0.2% obtains the lotion slow down with skin irritatin.
Embodiment 3
A kind of preparation method for the plant extract composition for having effects that slow down skin irritatin, comprising the following steps:
(1) raw material is weighed according to following weight: 20g parts of Fourstamen Stephania Root, 45g parts of honeysuckle and coptis 20g, using deionized water
Cleaning, and dry；
(2) raw material after drying in step (1) is separately or concurrently crushed, squeezes out liquid；
(3) liquid that step (2) obtain is filtered, obtains extracting solution；
(4) preservative is added in the extracting solution that step (3) obtain, stirs evenly to get stephania tetrandra extract, honeysuckle is contained
The plant extract composition slow down with skin irritatin of extract and coptis extract.
Wherein, on the basis of single plant extracts gross mass, the content of tetrandrine is in stephania tetrandra extract
45wt%, the content of Honegsukle flower P.E Content of Chlorogenic Acid are 55wt%, and the content of Berberine hydrochloride is 70wt% in coptis extract.
A kind of preparation method for the lotion for having effects that slow down skin irritatin, comprising the following steps:
(1) it adds water in kettle, Kappa mother is added, impregnates 10min, heating stirring is all dissolved to raw material at a temperature of 83 DEG C
Completely；
(2) A phase raw material is continuously added, keeping the temperature 82 DEG C of stirrings, all dissolution completely, obtains A phase after heat preservation 10min sterilizing to raw material
Feedstock processing object is kept the temperature spare；A phase raw material: EDTA-2Na 0.2%, Kappa mother 0.6%, glycerol 3%, panthenol 0.8%, trehalose
1.5%, 1,3-BDO 3% has effects that the plant extract composition 3% for slowing down skin irritatin, and surplus is water；
(3) B phase raw material is added in oily phase pot, 82 DEG C of agitating and heating dissolutions completely, are kept the temperature spare；B phase raw material: PEG-100 is hard
Resin acid ester 2%, cetostearyl alcohol 1%, tristerin 0.8%, polyisobutene 5%, caprylic capric glyceryl ester 3%, Butyrospermum parkii
2%, different ten six 5%；
(4) A phase feedstock processing object obtained in step (2) is pumped into emulsion pot, B phase raw material is pumped into cream under homogeneous stirring
Change in pot, homogeneous 5min, starts to cool down after stirring heat preservation 10min；
(5) when temperature drops to 42 DEG C, C phase raw material is added in emulsion pot, discharges after mixing evenly, C phase raw material: 10%NaOH
2%, preservative 0.15% obtains the lotion slow down with skin irritatin.
Embodiment 4
A kind of preparation method for the Essence for having effects that slow down skin irritatin, comprising the following steps:
(1) it adds water in kettle, is heated to 80~85 DEG C；
(2) other raw materials of A phase are added, keeping the temperature 80~85 DEG C of stirrings, all dissolution completely, cools down after heat preservation 10min sterilizing to raw material
To 40~45 DEG C；
(3) B phase raw material is added in kettle, stirring and dissolving is complete；
(4) C phase raw material is added in kettle, stirs evenly discharging, obtains the Essence slow down with skin irritatin.
Wherein:
A phase raw material: EDETATE SODIUM 0.01~0.3%, xanthan gum 0.02~1%, butanediol 1~5%, panthenol 0.1~1%, to hydroxyl
0.1~2%, 1,2- pentanediol 0.2~4% of acetophenone, water 60~90%；
B phase raw material: biological carbohydrate gum 11~5%, plant extract composition 1~8%；
C phase raw material: Cremophor RH40 0.1~2.5%, (daily) essence 0.01~0.2%.
To the plant extract composition slow down with skin irritatin of the invention on HaCat cell model cell viability
Efficacy assessments, experimental program:
It selects the HaCat cell newly bought and SLS to be tested, is uniformly spread with 1X104/well to 96 orifice plates, be inoculated with 24 hours
Afterwards, the sample of various concentration is added, is incubated for 4 h, 4 × SLS of various concentration is added, after 37 DEG C of culture 20h, abandons supernatant, often
200ulMTT solution is added in hole.37 DEG C, 5%CO2 is incubated for 4h, abandons supernatant, and every hole is added 150ul DMSO and melts, room temperature concussion
Absorption value is measured after 10min at 490nm.
The stimulation of SLS can be effectively relieved in the plant extract composition to experimental result as shown in Figure 1:, and it is thin to effectively improve HaCat
The cell viability of born of the same parents, it is maximum up to 47.07%.
To the plant extract composition slow down with skin irritatin of the invention in macrophage Raw264.7 model
The evaluation of upper anti-inflammatory efficacy (PGE2), experimental program:
Raw264.7 cell and LPS is selected to be tested.Raw264.7 cell is uniformly spread to 96 orifice plates with 5X104/well, is connect
The given the test agent (LPS and various concentration folk prescription) of various concentration is added after 37 DEG C of 24 h of culture after 24 hours in kind, collects supernatant
PGE2 is detected for Elisa, 200ul neutral red solution is added in every hole.37 DEG C, 5%CO2 is incubated for 3 h, abandons supernatant, and every hole is added
150ul eluent, melts, and room temperature measures absorption value after mildly shaking 10min at 540 nm.Made with GraphPad software
Map analysis calculates.
As a result as shown in Figure 2: the expression for the inflammatory factor PGE2 that the plant extract composition can effectively inhibit LPS to induce,
In 0.1% concentration, inhibiting rate reaches 72.64%.
It can see by above-mentioned cell experiment, plant extract composition provided by the invention can effectively improve epidermis
The cell viability of cell, inhibits the expression of macrophage inflammatory factor, and antiphlogistic effects are significant.The plant extract composition is a kind of
Have effects that alleviate the pure plant raw material of skin irritatin.According to using approach different, can be used for being added to a variety of cosmetics,
It is not limited to lotion or aqua in skin care item and other external-use skin care preparations, can also be fabricated to facial cleanser, face cream, facial mask, essence
Liquid, toner, skin cream etc..Above-mentioned plant extract composition can be made according to known method in skin care industry field
A variety of different external preparations.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the present invention in any form, and is not surpassing
There are also other variations and modifications under the premise of technical solution documented by claim out.
Claims (9)
1. a kind of plant extract composition for having effects that slow down skin irritatin, which is characterized in that it is described have slow down skin thorn
The plant extract composition for swashing effect is grouped as by the group of following parts by weight: 10~40 parts of stephania tetrandra extract, honeysuckle is extracted
Object 10~80 and 10~40 parts of coptis extract.
2. a kind of plant extract composition for having effects that slow down skin irritatin according to claim 1, which is characterized in that
On the basis of single plant extracts gross mass, the content of tetrandrine is 10 ~ 98wt% in the stephania tetrandra extract, described
The content of Honegsukle flower P.E Content of Chlorogenic Acid is 10 ~ 98wt%, in the coptis extract content of Berberine hydrochloride be 10 ~
98wt%。
3. one kind has effects that the preparation method for the plant extract composition for slowing down skin irritatin as described in claim 1,
It is characterized in that, comprising the following steps:
(1) raw material is weighed according to following weight: 10~40 parts of Fourstamen Stephania Root, 10~80 parts of honeysuckle and the coptis 10~40
Part, it is cleaned with deionized water, and dry；
(2) raw material after drying in step (1) is separately or concurrently crushed, squeezes out liquid；
(3) liquid that step (2) obtain is filtered, obtains extracting solution；
(4) preservative is added in the extracting solution that step (3) obtain, stirs evenly to get having effects that slow down skin irritatin
Plant extract composition.
4. having effects that the plant extract composition for slowing down skin irritatin in cosmetics and external-use skin care as described in claim 1
Application in preparation.
5. a kind of external-use skin care preparation for having effects that slow down skin irritatin, which is characterized in that slow down skin irritatin function to have
On the basis of the external-use skin care preparation gross mass of effect, it is described have effects that slow down in the external-use skin care preparation of skin irritatin containing 1 ~
8wt%'s has effects that the plant extract composition for slowing down skin irritatin as described in claim 1.
6. a kind of external-use skin care preparation for having effects that slow down skin irritatin according to claim 5, which is characterized in that institute
Stating external-use skin care preparation is facial cleanser, face cream, facial mask, Essence, toner, lotion or aqua.
7. a kind of lotion for having effects that slow down skin irritatin, which is characterized in that have effects that the lotion for slowing down skin irritatin
It is described to have effects that the lotion for slowing down skin irritatin is made of the raw material of following mass percentage on the basis of gross mass:
A phase raw material: EDTA-2Na 0.1~0.3%, Kappa mother 0.2~1%, glycerol 1~5%, panthenol 0.1~1%, trehalose 1~
2%, 1,3-BDO 2~4%, have effects that slow down as described in claim 1 the plant extract composition 1 of skin irritatin~
8%, water 60~80%；
B phase raw material: PEG-100 stearate 1~3%, cetostearyl alcohol 0.5~1.5%, tristerin 0.5~1% gather different
Butylene 2~7%, caprylic capric glyceryl ester 1~5%, Butyrospermum parkii 0.5~3%, isohexadecane 2~7%；
C phase raw material: 10%NaOH 0.4~2.5%, preservative 0.1~0.2%.
8. a kind of lotion for having effects that slow down skin irritatin according to claim 7, which is characterized in that it is described have subtract
Has effects that the plant for slowing down skin irritatin as described in claim 1 containing 1 ~ 5wt% in the lotion of slow skin irritatin effect
Extract composition.
9. one kind has effects that the preparation method for the lotion for slowing down skin irritatin, feature exist as claimed in claim 7 or 8
In, comprising the following steps:
(1) it adds water in kettle, Kappa mother is added, impregnates 10min, heating stirring is whole to raw material at a temperature of 80~85 DEG C
Dissolution is complete；
(2) A phase raw material is continuously added, keeping the temperature 80~85 DEG C of stirrings, all dissolution completely, obtains after heat preservation 10min sterilizing to raw material
A phase feedstock processing object is kept the temperature spare；
(3) B phase raw material is added in oily phase pot, 80~85 DEG C of agitating and heating dissolutions completely, are kept the temperature spare；
(4) A phase feedstock processing object obtained in step (2) is pumped into emulsion pot, B phase raw material is pumped into cream under homogeneous stirring
Change in pot, homogeneous 5min, starts to cool down after stirring heat preservation 10min；
(5) when temperature drops to 40~45 DEG C, in emulsion pot be added C phase raw material, discharge after mixing evenly, obtain have subtract
The lotion of slow skin irritatin effect.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111979289A (en) * | 2020-07-22 | 2020-11-24 | 上海珈蓓生物科技有限公司 | Cytological evaluation method for resistance of plant extracts to skin chemical stimulation and application of cytological evaluation method |
| CN113318166A (en) * | 2021-06-30 | 2021-08-31 | 植然天成(北京)生物科技有限公司 | Plant composition and preparation method and application thereof |
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