CN109843333A - 具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用 - Google Patents

具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用 Download PDF

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CN109843333A
CN109843333A CN201880003668.8A CN201880003668A CN109843333A CN 109843333 A CN109843333 A CN 109843333A CN 201880003668 A CN201880003668 A CN 201880003668A CN 109843333 A CN109843333 A CN 109843333A
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drug
cancer
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pki
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CN109843333B (zh
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李高全
汪斌
李大军
张倩
黄蕾
陈毛芬
吴晓丹
彭良艳
何婷婷
张艳艳
唐云
刘欢
税举媛
张翠芳
李建环
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Chongqing Upgra Biological Sci & Tech Ltd
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Chongqing Upgra Biological Sci & Tech Ltd
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Abstract

具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物，其制备方法和应用。该中间体药物的结构通式为(I)，聚乙二醇偶联协同抗癌药物的结构通式为(II)，上述药物能够实现多种抗癌药物之间的联合用药，避免在单独服用多种抗癌药物时由于药物之间的相互影响以及药代动力学而导致的毒性反应，且有利于克服癌症的多药耐药性，具有协同增效的作用，可用于制备抗癌药物及用于治疗癌症。

Description

PCT国内申请，说明书已公开。

Claims (29)

  1. PCT国内申请，权利要求书已公开。
CN201880003668.8A 2017-08-30 2018-01-22 具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用 Active CN109843333B (zh)

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CN201710761572.5A CN107670048B (zh) 2017-08-30 2017-08-30 具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用
CN2017107615725 2017-08-30
PCT/CN2018/073662 WO2019041733A1 (zh) 2017-08-30 2018-01-22 具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用

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CN109843333A true CN109843333A (zh) 2019-06-04
CN109843333B CN109843333B (zh) 2023-02-03

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