CN109843256B - 化妆品用防腐剂组合物 - Google Patents

化妆品用防腐剂组合物 Download PDF

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CN109843256B
CN109843256B CN201880003093.XA CN201880003093A CN109843256B CN 109843256 B CN109843256 B CN 109843256B CN 201880003093 A CN201880003093 A CN 201880003093A CN 109843256 B CN109843256 B CN 109843256B
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金峰出
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Abstract

本发明的防腐组合物的特征在于包含1,2‑己二醇、辛二醇、丁二醇、戊二醇、乙基己基丙三醇、路易波士萃取物、甘草萃取物、没药萃取物、紫苏叶萃取物、丝兰萃取物。本发明的化妆品用防腐剂组合物不仅防止化妆品的酸败而且没有有害性和毒性，因此对皮肤没有刺激，能够制造保湿力优异的化妆品。

Description

化妆品用防腐剂组合物
技术领域
本发明涉及化妆品用防腐剂组合物。
背景技术
作为化妆品中使用的必需成分，需要防止内容物的酸败的防腐剂成分。与此相关的状况是，传统上一直用作化妆品或生活用品用防腐剂的对羟基苯甲酸酯(parabens)系列的化学物质从数年前开始频繁地被提出有害性问题。再加上各国制订了针对强化致癌物或能够对生殖器产生影响的化妆品含有成分的管制的化妆品法，对化妆品用防腐剂的警戒心也再次高涨。
因此，现状是没有有害性和毒性的替代化妆品用防腐剂的必要性高涨，业界也在加速努力，想要开发天然且更安全，能够替代对羟基苯甲酸酯的化妆品用防腐剂。此外，也持续开发推出完全不含有对羟基苯甲酸酯的防腐剂等新产品。
发明内容
发明要解决的问题
本发明的目的在于制造没有有害性和毒性的化妆品用防腐剂组合物。
此外，本发明的组合物的目的在于不仅具有防腐效果还具有保湿效果。
解决问题的方案
本发明的防腐剂组合物的特征在于包含：1,2-己二醇、辛二醇、丁二醇、戊二醇、乙基己基丙三醇、路易波士萃取物、甘草萃取物、没药萃取物、紫苏叶萃取物、丝兰萃取物。
没药性平，味苦。本发明的目的在于制造没有有害性和毒性的化妆品用防腐剂组合物。
此外，本发明的组合物的目的在于不仅具有防腐效果还具有保湿效果。无毒。破结和宿血，终止痛症。可治愈跌打伤、骨和腱损伤或断裂而宿血瘀积所导致的疼痛、铁器击伤、棍棒击打产生的伤、各种恶疮和痔瘘。此外消除肿毒，抑制突然出血，治愈因眼中产生翳障而眩晕疼痛、其周围血管突出。
紫苏叶性温，味辛，无毒。治疗心窝底胀满和霍乱、脚气等，使大小便通畅。消除整个寒气，风寒时解表邪。此外消降胸中的痰和气。这样的紫苏叶萃取物有消炎作用及抑制肿瘤、抗过敏的效果。
丝兰萃取物作为用水萃取丝兰的根而获得的物质，为了保存品质能够添加稀释剂及其它食品添加物。其是暗褐色的液体，作为具有特别的气味的芳香剂，包含皂苷配糖体，因此与水振荡会产生气泡。当添加到清凉饮料、鸡尾酒等中时，气泡长时间维持，在pH2～10时产生泡沫，泡沫具有稳定性。
上述没药萃取物、紫苏叶萃取物、丝兰萃取物的特征在于在整个组合物中分别为0.1～0.5重量％。这是因为，如果小于0.1重量％，则上述防腐效果低微。如果超过0.5重量％，则会引起对皮肤的刺激。
路易波士作为属于豆科植物的针叶树，路易波士中没有咖啡因，含有丰富的矿物质，活用于茶道，有益于皮肤健康，对于暴露在紫外线中的皮肤，保护皮肤免受成为皮肤老化的原因的活性氧的伤害而预防皮肤的氧化性损伤，由此有助于皮肤皱纹的管理及缓和。
甘草具有解毒作用、解除宿醉、消炎作用、抗癌效果、伤口治疗、促进皮肤机能代谢等效果。
上述路易波士萃取物、甘草萃取物的特征在于分别为0.1～0.5重量％。这是因为，如果小于0.1重量％，则上述皮肤保湿、防止老化效果低微，如果超过0.5％重量％，则能够引起对皮肤的刺激。
此外，本发明的特征在于为包含上述组成的防腐剂组合物的、保湿效果及酸败防止效果优异的化妆品。
发明效果
本发明的化妆品用防腐剂组合物不仅防止化妆品的酸败而且没有有害性和毒性，因此能够制造对皮肤没有刺激的化妆品。
此外，本发明的组合物能够制造不仅具有防腐效果而且保湿效果也优异的功能性化妆品。
附图说明
图1～图6为对表1的组合物的细菌增殖进行实验的结果和照片。
图7为实施例2的乳霜剂型A的防腐力试验结果报告书。
图8为实施例2的乳霜剂型A的对数减少图。
图9为实施例2的乳霜剂型A的细菌增殖测试照片。
图10为实施例2的乳霜剂型B的防腐力试验结果报告书。
图11为实施例2的乳霜剂型B的对数减少图。
图12为实施例2的乳霜剂型B的细菌增殖测试照片。
图13为包含本发明的实施例3的防腐剂组合物的乳霜的防腐力试验结果报告书。
图14为包含本发明的实施例3的防腐剂组合物的乳霜的对数减少图。
图15为包含本发明的实施例3的防腐剂组合物的乳霜的细菌增殖测试照片。
具体实施方式
以下结合实施例进一步详细说明本发明。
实施例1:1次实验
在表2的基础底物(base)中，如表1所述，使防腐剂组合物以3种(A,B,C)类型分别含有0.8％，进行实验。
首先加入路易波士萃取物和甘草萃取物的理由是，在保湿剂中，辛二醇示出高刺激，考虑到刺激，为了缓和刺激，分别以0.5％添加。
表1
Figure BDA0001966409420000041
表2
原料名 含量(％)
纯化水 到100
丙三醇 1.00
山梨醇 3.00
黄原胶 0.15
羟乙基纤维素 0.15
硬脂醇 4
硬脂酸己六酯 0.7
聚山梨醇酯60 1
矿物油 6
芥花油 5
二甲基硅油 0.3
防腐原料(A，B，C) 0.8
1.实验条件
2.试验菌株
1)细菌(Bacteria):金黄色葡萄球菌(Staphylococcus aureus)(KCTC 1916)
大肠杆菌(Escherichia coli)(KCTC 2571)
绿脓杆菌(Pseudomonas aeruginosa)(KCTC 1750)
枯草杆菌(Bacillus subtillis)(KCTC 2189)
2)酵母菌(Yeast)：白念珠菌(Candida albicans)(KCTC 7965)
3)真菌(Fungi)：黑曲霉(Aspergillus niger)(KCCM 11239)
3.试验基准
接种后7天时观察到细菌的减少率为99.9％以下(减少3Log)，酵母菌、真菌的减少率为99％(减少2Log)，接种后14天时没有增殖。
4.实验结果
上述实验结果如图1～6所示，各组别的内容示于下述表4中。
表3
Figure BDA0001966409420000051
实验结果如图1～6所示，在包含1,2-己二醇、辛二醇、丁二醇、路易波士萃取物、甘草萃取物的防腐剂组合物中，实验菌的减少率及增殖效果没有达到基准。
实施例2:2次实验
基于上述1次实验的导出数据，修改了各项目的含量，追加了新型项目(戊二醇、乙基己基丙三醇)。投入量与基准相同，投入0.8％。
B追加没药萃取物、紫苏叶萃取物、丝兰萃取物，基础底物与1次实验相同。
表4
Figure BDA0001966409420000061
表5
原料名 含量
纯化水 到100
丙三醇 1.00
山梨醇 3.00
黄原胶 0.15
羟乙基纤维素 0.15
硬脂醇 4
硬脂酸己六酯 0.7
聚山梨醇酯60 1
矿物油 6
芥花油 5
二甲基硅油 0.3
防腐原料(A，B) 0.8
1.实验条件
2.试验菌株
1)细菌(Bacteria)：金黄色葡萄球菌(Staphylococcus aureus)(KCTC 1916)
大肠杆菌(Escherichia coli)(KCTC 2571)
绿脓杆菌(Pseudomonas aeruginosa)(KCTC 1750)
枯草杆菌(Bacillus subtillis)(KCTC 2189)
2)酵母菌(Yeast)：白念珠菌(Candida albicans)(KCTC 7965)
3)真菌(Fungi)：黑曲霉(Aspergillus niger)(KCCM 11239)
3.试验基准
接种后7天时观察到细菌的减少率为99.9％以下(减少3Log)，酵母菌、真菌的减少率为99％(减少2Log)，接种后14天时没有增殖。
4.实验结果
表6
Figure BDA0001966409420000071
在2次实验中，除追加的3种萃取物以外的剩余的品种相同，含量在数值上有所差异。结果可知没药萃取物、紫苏叶萃取物、丝兰萃取物有助于产品的防腐力。
实施例3:3次实验将追加的3种萃取物的含量从0.3％减少为0.1％，进行实验。
表7
Figure BDA0001966409420000081
表8
Figure BDA0001966409420000082
1.实验条件
2.试验菌株
1)细菌(Bacteria):金黄色葡萄球菌(Staphylococcus aureus)(KCTC 1916)
大肠杆菌(Escherichia coli)(KCTC 2571)
绿脓杆菌(Pseudomonas aeruginosa)(KCTC 1750)
枯草杆菌(Bacillus subtillis)(KCTC 2189)
2)酵母菌(Yeast)：白念珠菌(Candida albicans)(KCTC 7965)
3)真菌(Fungi)：黑曲霉(Aspergillus niger)(KCCM 11239)
3.试验基准
接种后7天时观察到细菌的减少率为99.9％以下(减少3Log)，酵母菌、真菌的减少率为99％(减少2Log)，接种后14天时没有增殖。
4.实验结果
表9
Figure BDA0001966409420000091
*即使将没药萃取物、紫苏叶萃取物、丝兰萃取物的含量分别降低为0.1重量％，防腐效果也一样。
实施例4：官能测试
*制造包含上述实施例2及实施例3的防腐剂组合物及表8的底物的化妆品，选定30名20～50代的女性，让其使用6个月，测试是否有皮肤刺激。
早晚在脸上涂抹1g，使其吸收，测定皮肤刺激及保湿力，调查满意度。(5.没有皮肤刺激，保湿力非常好，4.略微感到皮肤刺激，保湿力好，3.皮肤刺激一般，保湿力一般，2.皮肤刺激大，保湿力非常低，1.皮肤刺激非常大，没有保湿力)
确认了30名测试者几乎全部回答没有感受到皮肤刺激，皮肤不干燥，维持水润状态。(皮肤刺激：平均4.8，保湿力：平均4.7)。根据这样的评价结果，本发明的组合物示出了没有皮肤刺激、抑制化妆品的细菌增殖的防腐效果优异、提高皮肤保湿度、令使用者具有满足感的卓越效果。

Claims (3)

1.一种化妆品用天然防腐剂组合物，具有缓和皮肤刺激功能及保湿力，包含1,2-己二醇、辛二醇、丁二醇、戊二醇、乙基己基丙三醇、路易波士萃取物、甘草萃取物、没药萃取物、紫苏叶萃取物及丝兰萃取物，其特征在于，所述路易波士萃取物、甘草萃取物、没药萃取物、紫苏叶萃取物及丝兰萃取物分别为0.1～0.5重量％。
2.根据权利要求1所述的化妆品用天然防腐剂组合物，其特征在于，所述没药萃取物、紫苏叶萃取物、丝兰萃取物分别为0.1～0.3重量％。
3.一种化妆品，具有缓和皮肤刺激功能及保湿力，包含权利要求1至权利要求2中任一项的防腐剂组合物。
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