CN109828007A - A kind of biological monitor based on biological solution concentration - Google Patents
A kind of biological monitor based on biological solution concentration Download PDFInfo
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- CN109828007A CN109828007A CN201910158575.9A CN201910158575A CN109828007A CN 109828007 A CN109828007 A CN 109828007A CN 201910158575 A CN201910158575 A CN 201910158575A CN 109828007 A CN109828007 A CN 109828007A
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Abstract
The present invention relates to a kind of biological monitors based on biological solution concentration, it include: pedestal, outer housing, main body, rotating disk, work nest is provided on rotating disk central axis, work groove groove wall is filter screen, work nest is internally provided with the second rotary shaft, crushing piece is provided in second rotary shaft, work nest upper end is opening, opening is provided with sealing cover, second rotary shaft is connected to sealing cover, double-helix partition is additionally provided with inside rotating disk, double-helix partition end and rotating disk form crystallizing field, crystallizing field is corresponded in main body to open up via region inswept after the rotation of the first rotary shaft as lead-over groove, lead-over groove is passed through body interior by transmission channel, main body includes inner cavity, enzyme electrode, current measurement circuit, processing unit, solvent is full of in inner cavity, enzyme electrode is used to detect the biochemical system substance of detected solution, electric current is surveyed The current value of circuit detection enzyme electrode is measured, processing unit analyzes biological sample according to the measured value of enzyme electrode and current measurement circuit.
Description
Technical field
The present invention relates to field of biological detection more particularly to a kind of biological monitors based on biological solution concentration.
Background technique
With the rapid development of science and technology, people increasingly pay close attention to the detection of physiologically substance.This substance, such as grape
Sugar, lactic acid, amino acid equal size is not only in field of medicaments as the normal judgment basis of Human Physiology index, and in chemical industry
The industries such as fermentation are also used as important product index.Therefore, the highly sensitive biology for meeting the market demand is designed and prepared out
Detector has solid practical basis and extensive market prospects.But it is traditional can buy on the market for examining
The instrument of physical signs is surveyed, such as blood glucose meter is all generally only capable of measuring single content of material.But often there is bad disease in human body
All be not merely that a kind of index tends to abnormal condition when shape or chronic disease, the detection of multi objective and compare for
The control of disease, the use of drug and the adjustment of dosage all have apparent help.However, each physiologically substance is all in human body
With respective detectable limit and concentration range, what is had may differ several orders of magnitude.This is difficult in a kind of electronic module
In carry out unification, and the physiologically substance low for detectable limit, the high sensitivity of circuit are also very scabrous aspect.Institute
To prepare high sensitivity at present, the compound bio-detector of more physical signs test functions does not have exploitation also.
Summary of the invention
Goal of the invention:
For high sensitivity is prepared at present, the compound bio-detector of more physical signs test functions does not have asking for exploitation also
Topic, the present invention provide a kind of biological monitor based on biological solution concentration.
Technical solution:
A kind of biological monitor based on biological solution concentration detects, comprising: bottom for the liquid sample to biology
Seat, outer housing, main body, rotating disk, the outer housing coat the main body and rotating disk and connect the pedestal, the main body
The pedestal is connected, the rotating disk is set to the main body upper end, and the main body is connected to the rotating disk, the rotating disk
By main body described in the first rotation axis connection, it is provided with work nest on the rotating disk central axis, the work groove groove wall was
Strainer, the work nest are internally provided with the second rotary shaft, are provided with crushing piece in second rotary shaft, on the work nest
End is opening, and the opening is provided with sealing cover, and second rotary shaft is connected to the sealing cover, inside the rotating disk
It is additionally provided with double-helix partition, double-helix partition end and the rotating disk form crystallizing field, right in the main body
The crystallizing field is answered to open up via inswept region after first rotary shaft rotation as lead-over groove, the lead-over groove passes through transmission
Channel is passed through the body interior, and the main body includes inner cavity, enzyme electrode, current measurement circuit, processing unit, in the inner cavity
Full of solvent, the enzyme electrode is used to detect the biochemical system substance of detected solution, the current measurement circuit detection enzyme electricity
The current value of pole, the processing unit according to the measured value of the enzyme electrode and the current measurement circuit to biological sample into
Row analysis.
As a kind of preferred embodiment of the invention, the position that the crystallizing field is connected to the double-helix partition is provided with
One semi-permeable membrane, the first semi-permeable membrane filtering biological salt solute.
As a kind of preferred embodiment of the invention, the crystallizing field end extends to the lead-over groove, the portion of the extension
It is allocated as guiding groove, for guiding the filtered solution of the first semi-permeable membrane to lead-over groove.
As a kind of preferred embodiment of the invention, gravity door is arranged in the end of the crystallizing field, and the gravity door is certain
The solution of the first semi-permeable membrane filtering is accumulated in degree.
As a kind of preferred embodiment of the invention, the main body further includes time set, and the time set is for recording
The time that the gravity door is closed, the time set are provided with the crash time.
As a kind of preferred embodiment of the invention, the main body further includes control device, described in the control device control
Gravity door, the control device control the gravity door and open when judging the time set timing result beyond the crash time.
As a kind of preferred embodiment of the invention, the rotating disk is provided with water supply pipe, and the water supply pipe is for supplementing institute
State the moisture in rotating disk.
As a kind of preferred embodiment of the invention, the main body is connected with solvent make-up pipe and processing pipe, the processing
Pipe is for releasing the intracorporal solvent of the master, and the solvent make-up pipe is for supplementing the intracorporal solvent of the master.
The present invention realize it is following the utility model has the advantages that
Detection liquid is detected by centrifugal action removing to the solute in requisition for detection and using enzyme electrode, to solve
High sensitivity is prepared at present, the compound bio-detector of more physical signs test functions does not have the problem of exploitation also.
Detailed description of the invention
The drawings herein are incorporated into the specification and forms part of this specification, and shows the implementation for meeting the disclosure
Example, and consistent with the instructions for explaining the principles of this disclosure.
Fig. 1 is schematic diagram of the present invention；
Fig. 2 is detection plate schematic diagram；
Fig. 3 is system framework figure.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
Embodiment one:
It is Fig. 1, Fig. 2, Fig. 3 with reference to figure.A kind of biological monitor based on biological solution concentration, for the liquid-like to biology
This is detected, comprising: pedestal 1, outer housing 2, main body 3, rotating disk 4, the outer housing 2 coat the main body 3 and rotation
Disk 4 simultaneously connects the pedestal 1, and the main body 3 connects the pedestal 1, and the rotating disk 4 is set to 3 upper end of main body, described
Main body 3 is connected to the rotating disk 4, and the rotating disk 4 connects the main body 3 by the first rotary shaft 5, in the rotating disk 4
Work nest 6 is provided in mandrel, 6 cell wall of work nest is filter screen, and the work nest 6 is internally provided with the second rotary shaft 7,
Crushing piece is provided in second rotary shaft 7,6 upper end of work nest is opening, and the opening is provided with sealing cover, institute
It states the second rotary shaft 7 and is connected to the sealing cover, double helix is additionally provided with inside the rotating disk 4 and turns partition 8, the double helix
Turn 8 end of partition and the rotating disk 4 forms crystallizing field 9, the crystallizing field 9 is corresponded in the main body 3 via first rotation
Inswept region opens up as lead-over groove 10 after shaft 5 rotates, and the lead-over groove 10 is passed through in the main body 3 by transmission channel
Portion, the main body 3 include inner cavity, enzyme electrode 11, current measurement circuit 12, processing unit 13, are full of solvent, institute in the inner cavity
It states enzyme electrode 11 and detects the electricity of enzyme electrode 11 for detecting the biochemical system substance of detected solution, the current measurement circuit 12
Flow valuve, the processing unit 13 according to the measured value of the enzyme electrode 11 and the current measurement circuit 12 to biological sample into
Row analysis.
As a kind of preferred embodiment of the invention, the crystallizing field 9, which is connected to the double helix and turns the position of partition 8, to be provided with
First semi-permeable membrane 14, the 14 filtering biological salt solute of the first semi-permeable membrane.
As a kind of preferred embodiment of the invention, 9 end of crystallizing field extends to the lead-over groove 10, the extension
Part is used as guiding groove, for guiding the filtered solution of first semi-permeable membrane 14 to lead-over groove 10.
As a kind of preferred embodiment of the invention, gravity door 15 is arranged in the end of the crystallizing field 9, and the gravity door 15 exists
The solution that first semi-permeable membrane 14 filters is accumulated to a certain extent.
As a kind of preferred embodiment of the invention, the main body 3 further includes time set 16, and the time set 16 is used for
The time that the gravity door 15 is closed is recorded, the time set 16 is provided with the crash time.
As a kind of preferred embodiment of the invention, the main body 3 further includes control device 17, and the control device 17 controls
The gravity door 15, the control device 17 control described heavy when judging 16 timing result of time set beyond the crash time
Power door 15 is opened.
As a kind of preferred embodiment of the invention, the rotating disk 4 is provided with water supply pipe, and the water supply pipe is for supplementing institute
State the moisture in rotating disk 4.
As a kind of preferred embodiment of the invention, the main body 3 is connected with solvent make-up pipe and processing pipe, the processing
Pipe is used to supplement the solvent in the main body 3 for releasing the solvent in the main body 3, the solvent make-up pipe.
In the specific implementation process, a certain amount of biological moieties are added in the work nest 6 above rotating disk 4, such as set
The clast of leaf, biology, sealing cover will cover above work nest 6, and be driven in Section 2 rotary shaft by the rotation of the second rotary shaft 7
The crushing piece of setting rotates, the biological moieties cutting and grinding that will be placed into work nest 6.In the process of the second rotary shaft 7 work
In, the first rotary shaft 5 is also rotated, and the first rotary shaft 5 drives rotating disk 4 to rotate, and during rotating disk 4 rotates, is located at
Bioclast in work nest 6 oozes out certain soluble substance, including urea, glucose, amino acid, cholesterol etc., is dissolved in and setting
It sets among the solvent of rotating disk 4, bring centrifugal action, solute dissolved solution and biology is rotated by rotating disk 4
Clast is by the filter screen filtration as 6 cell wall of work nest, and bioclast filtered in work nest 6, solute dissolved solution
Enter double helix through filter screen and turns space at 8 partition of partition.During first rotary shaft 5 rotates, rotating disk 4 rotates,
Solution rotating disk 4 turns partition 8 to double helix generates certain centrifugal action so that the solute in solution gradually got rid of to
Double helix turns at the first semi-permeable membrane 14 of the end in the region of the partition of partition 8, and the first semi-permeable membrane 14 penetrates biogenic salt solute, due to
Biogenic salt solute is gradually constantly accumulated at the first semi-permeable membrane 14, in the biogenic salt solute of subsequent accumulation and being total to for centrifugal action
With under the influence of, biogenic salt solute enters the crystallizing field 9 of 14 rear end of the first semi-permeable membrane through the first semi-permeable membrane 14.Biogenic salt solute with
And the solution that partial solvent is formed accumulates in crystallizing field 9, when accumulation is more than the tolerance range of gravity door 15 in crystallizing field 9
When, gravity door 15 is turned on, and solution enters in lead-over groove 10 under the guidance of the guiding groove of 9 end of crystallizing field, in lead-over groove 10
Solution be transmitted to inside main body 3 via transmission channel, mix in the inside of main body 3 with the solvent being arranged in main body 3, formation is examined
Survey liquid.It is noted that crystallizing field 9, which can not often deposit, can reach 15 tolerance range of gravity door due to final stage, because
This, adds up 15 shut-in time of gravity door using time set 16, after the time that gravity door 15 is closed being more than the crash time,
Control device 17 controls gravity door 15 and opens, so that the solution in crystallizing field 9 enters in lead-over groove 10.
In main body 3, final detects liquid determinand sentence enzyme membrane diffusion in the catalytic action of enzyme, test solution, and and enzyme layer
Enzymic catalytic reaction occurs for contact, causes test substance activity to change, by electrode response;Or make determinand generation can be by the electricity
The ion of pole response, the indirect determination substance such as Urease electrode 11 is that urase is fixed on using NH3 electrode as indicator electrode
It is manufactured on the sensitive ventilated membrane of NH3 electrode.When the urea in test solution is contacted with urase, reaction of decomposing:
CO(NH2)2+ H2O-2NH3+CO2
The content of urea is measured by the ammonia of NH3 electrode detection reaction generation.The electrode can detecte 0.0 in blood plasma and serum
The urea of 5 ~ 5mmol.L, remaining substance equally measure, to accurately be measured to biological status.
In turn, it needs that the solvent in rotating disk 4 and main body 3 is supplemented or replaced, rotating disk 4 is provided with moisturizing
Pipe, water supply pipe are used to supplement the moisture in rotating disk 4.Main body 3 is connected with solvent make-up pipe and processing pipe, handles pipe for putting
Solvent in main body 3 out, solvent make-up pipe are used to supplement the solvent in main body 3.
The above embodiments merely illustrate the technical concept and features of the present invention, and the purpose is to allow the skill for being familiar with the technical field
Art personnel can understand the content of the present invention and implement it accordingly, and can not be limited the scope of the invention with this.All bases
Equivalent changes or modifications made by spirit of the invention, should be covered by the protection scope of the present invention.
Claims (8)
1. a kind of biological monitor based on biological solution concentration detects, comprising: bottom for the liquid sample to biology
Seat, outer housing, main body, rotating disk, the outer housing coat the main body and rotating disk and connect the pedestal, the main body
The pedestal is connected, the rotating disk is set to the main body upper end, and the main body is connected to the rotating disk, the rotating disk
Pass through main body described in the first rotation axis connection, it is characterised in that: work nest, the work are provided on the rotating disk central axis
Groove groove wall is filter screen, and the work nest is internally provided with the second rotary shaft, is provided with crushing piece in second rotary shaft, institute
Work nest upper end is stated as opening, the opening is provided with sealing cover, and second rotary shaft is connected to the sealing cover, described
Double-helix partition is additionally provided with inside rotating disk, double-helix partition end and the rotating disk form crystallizing field, institute
It states and corresponds to the crystallizing field in main body and open up via inswept region after first rotary shaft rotation as lead-over groove, the transition
Slot is passed through the body interior by transmission channel, and the main body includes inner cavity, enzyme electrode, current measurement circuit, processing unit,
Solvent is full of in the inner cavity, the enzyme electrode is used to detect the biochemical system substance of detected solution, the current measurement electricity
The current value of enzyme electrode is detected on road, and the processing unit is according to the enzyme electrode and the measured value pair of the current measurement circuit
Biological sample is analyzed.
2. a kind of biological monitor based on biological solution concentration according to claim 1, it is characterised in that: described heavy
The position that product area is connected to the double-helix partition is provided with the first semi-permeable membrane, the first semi-permeable membrane filtering biological salt solute.
3. a kind of biological monitor based on biological solution concentration according to claim 1, it is characterised in that: described heavy
The end Ji Qu extends to the lead-over groove, and the part of the extension is as guiding groove, for will be after first semi-permeable membrane filters
Solution guide to lead-over groove.
4. a kind of biological monitor based on biological solution concentration according to claim 3, it is characterised in that: described heavy
Gravity door is arranged in the end in product area, and the gravity door accumulates the solution of the first semi-permeable membrane filtering to a certain extent.
5. a kind of biological monitor based on biological solution concentration according to claim 4, it is characterised in that: the master
Body further includes time set, and the time set is used to record the time that the gravity door is closed, and the time set is provided with
Crash time.
6. a kind of biological monitor based on biological solution concentration according to claim 5, it is characterised in that: the master
Body further includes control device, and the control device controls the gravity door, and the control device judges the time set timing
The gravity door is controlled when as a result exceeding the crash time to open.
7. a kind of biological monitor based on biological solution concentration according to claim 1, it is characterised in that: the rotation
Turntable is provided with water supply pipe, and the water supply pipe is used to supplement the moisture in the rotating disk.
8. a kind of biological monitor based on biological solution concentration according to claim 1, it is characterised in that: the master
Body is connected with solvent make-up pipe and processing pipe, and the processing pipe is for releasing the intracorporal solvent of the master, the solvent make-up
Pipe is for supplementing the intracorporal solvent of the master.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910158575.9A CN109828007B (en) | 2019-03-04 | 2019-03-04 | Biological detection device based on biological solution concentration |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910158575.9A CN109828007B (en) | 2019-03-04 | 2019-03-04 | Biological detection device based on biological solution concentration |
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| CN109828007A true CN109828007A (en) | 2019-05-31 |
| CN109828007B CN109828007B (en) | 2021-12-17 |
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| CN110780688A (en) * | 2019-11-04 | 2020-02-11 | 温州博海生物科技有限公司 | Portable biological precision detection instrument of intelligence temperature adaptation |
| CN111678749A (en) * | 2020-04-24 | 2020-09-18 | 苏州格目软件技术有限公司 | Biological detection platform based on liquid compression |
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| Publication number | Publication date |
|---|---|
| CN109828007B (en) | 2021-12-17 |
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