CN107966578A - A kind of medical quick biochemical detection system and detection method - Google Patents
A kind of medical quick biochemical detection system and detection method Download PDFInfo
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- CN107966578A CN107966578A CN201711430575.7A CN201711430575A CN107966578A CN 107966578 A CN107966578 A CN 107966578A CN 201711430575 A CN201711430575 A CN 201711430575A CN 107966578 A CN107966578 A CN 107966578A
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- 238000001514 detection method Methods 0.000 title claims abstract description 244
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 125
- 210000002381 plasma Anatomy 0.000 claims abstract description 66
- 238000004140 cleaning Methods 0.000 claims abstract description 48
- 239000012459 cleaning agent Substances 0.000 claims abstract description 24
- 238000012360 testing method Methods 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000002504 physiological saline solution Substances 0.000 claims abstract description 13
- 230000035479 physiological effects, processes and functions Effects 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 238000012546 transfer Methods 0.000 claims abstract description 6
- 210000004369 blood Anatomy 0.000 claims description 70
- 239000008280 blood Substances 0.000 claims description 69
- 239000000523 sample Substances 0.000 claims description 60
- 238000000034 method Methods 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 14
- 230000003287 optical effect Effects 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 210000002966 serum Anatomy 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 7
- 238000007689 inspection Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 5
- 230000002949 hemolytic effect Effects 0.000 claims description 4
- 230000000717 retained effect Effects 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 2
- 238000005070 sampling Methods 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000010790 dilution Methods 0.000 abstract description 14
- 239000012895 dilution Substances 0.000 abstract description 14
- 210000004027 cell Anatomy 0.000 abstract description 6
- 239000007788 liquid Substances 0.000 description 8
- 238000002835 absorbance Methods 0.000 description 7
- 230000033001 locomotion Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 238000007865 diluting Methods 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
- 229960002897 heparin Drugs 0.000 description 4
- 229920000669 heparin Polymers 0.000 description 4
- 206010018910 Haemolysis Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 101150038956 cup-4 gene Proteins 0.000 description 3
- 230000008588 hemolysis Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000012982 microporous membrane Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical group C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000013215 result calculation Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
- G01N21/763—Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7783—Transmission, loss
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00475—Filters
- G01N2035/00485—Filters combined with sample carriers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00495—Centrifuges
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1032—Dilution or aliquotting
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- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention provides a kind of medical quick biochemical detection system and detection method, the system includes special detector and the supporting detection card for being used to be installed on tumbler, and the detection card is equipped with reagent cup, specimen cup, physiology salt cup, cleaning agent cup and cleaning cup；Reagent cup is used to place reagent；Specimen cup is used to place sample；Physiology salt cup is used to place physiological saline；Cleaning agent cup is used to place cleaning agent；Cleaning cup is used to place ejected wash water.One detection card of the system first use can be rapidly completed to the multiple item detections of sample, and can carry out double reagent detection, and by instrument to detection card centrifugal separating cell and blood plasma, easy to operate, testing result is more accurate.The system instrument be also equipped with to beyond detection range sample without separately using reagent, sample can automatic decision perform dilution check function.Detection blocks different between each cup, and sample and reagent are by the quantitative transfer in order of instrument suction needle during detection.
Description
Technical field
The present invention relates to medicine to detect clothing arts, particularly a kind of medical quick biochemical detection system and detection method.
Background technology
The important indicator that biochemical analysis and detection is clinical diagnosis is carried out to blood sample, urgent feelings are frequently run onto in clinical position
Need to be rapidly completed biochemistry detection under condition, valuable time is striven to obtain for patient's treatment.Therefore given birth to for Emergency Patients Rapid Implementation
It is particularly significant to change detection.But existing quick Biochemical Analyzer system is based primarily upon dry type Lateral Flow Strip, its testing result with
Liquid-type Biochemical Analyzer is compared there are disturbing factor is more, testing result accuracy is poor, and detection project is also subject to detection method to limit
System, although causing detection speed to be comparatively fast difficult to Accurate Diagnosis, or can not provide enough diagnostic messages.And currently used liquid
Body formula automatic biochemistry analyzer has that detection project is comprehensive, detection method is more, testing result accuracy is high, but equipment volume Pang
Greatly, apparatus structure is complicated, and reagent consumptive material consumes greatly, and operation is cumbersome, can not meet clinical rapid, bed sideization detection and open country
Detection under the conditions of outer first aid needs.And big bottle reagent opens wide for a long time and detection reagent pin takes reagent repeatedly, can cause reagent
Using to later stage actual constituent content change, enzymatic activity decline etc. influence testing result.
The content of the invention
Goal of the invention：The technical problems to be solved by the invention are in view of the deficiencies of the prior art, there is provided a kind of medical fast
Fast biochemical detection system and detection method.
In order to solve the above technical problem, the present invention provides a kind of medical quick biochemistry detection card device, including installation
Detection card on tumbler, the detection, which blocks, is equipped with more than one reagent cup and specimen cup, between each cup independently of each other
It is not communicated with；Each reagent cup pre-installs different reagents, each project needed for each detection project respectively has first reagent
Cup, each project are completed to react and detect in corresponding first reagent cup；
Specimen cup is used to place sample, including whole blood, blood plasma or serum.
In the present invention, the detection card is equipped with the second reagent cup, and prestore the second reagent, and sample is added in the first reagent cup
After product, draw the second reagent in the second reagent cup and add in the first reagent cup, reacted after mixing.But some projects only have
One reagent, without the second reagent, can be reacted after the first reagent and sample blending.
In the present invention, the detection card is additionally provided with cup, cup prepackage distilled water or physiological saline, inhales sample for cleaning
Pin, dilute sample or reaction solution.
In the present invention, the detection card is additionally provided with cleaning agent cup, cleaning agent is pre-installed, for cleaning suction needle.
In the present invention, the specimen cup prepackage Quantitative Haemolytic agent on detection card.
In the present invention, the specimen cup is diplopore cup, including two parts being connected of whole blood cup and blood plasma cup, wherein whole blood
Cup is located at the outside of detection card, miillpore filter is equipped between the blood plasma cup and whole blood cup positioned at the inner side of detection card, blood plasma cup,
Blood sample is added into the whole blood cup positioned at detection card inner side in advance during use, then detection card is installed in detection card rotating disk,
Using the tumbler centrifugal force that rotation is formed at a high speed, the blood plasma in blood sample is driven to enter the blood positioned at outside by miillpore filter
Slurry cup, haemocyte are retained in whole blood cup.
The invention also discloses a kind of medical quick biochemical detection system, detector control detection card rotation, the detection
Instrument includes control and data processing unit, suction needle and buanch unit, incubates storehouse, detection plate rotary system, detection unit and clear
Wash unit, control and data processing unit control suction needle and buanch unit, detection plate rotary system, detection unit and cleaning are single
The operation of member.
In the present invention, the detection card and detection unit are arranged on and incubate in storehouse, and it is 35-45 DEG C to incubate the temperature in storehouse.
In the present invention, suction needle and buanch unit include suction needle, diluter and suction needle mobile device, and sample pin moves
Dynamic device includes sample pin movement pipeline and the first motor, the second motor and the valve that are arranged on sample pin movement pipeline,
First motor and the second motor control suction needle up and down motion and side-to-side movement respectively.
In the present invention, suction needle cleaning unit includes Cleaning pipes and the pump being arranged in Cleaning pipes, Cleaning pipes
Both ends are respectively washed pin and washer bottle, and cleaning solution is placed with washer bottle, and cleaning needle lower end is equipped with service sink.
In the present invention, detection unit includes one group of optical detection apparatus, and optical detection apparatus includes light source and photosignal
Receiver.
The invention also discloses a kind of detection method of medical quick biochemical detection system, include the following steps：
Step 1：Take quantitative whole blood to be added in the whole blood cup of specimen cup, and whole blood cup is placed on detection card；
Step 2：Detection card is placed on tumbler, draws quantitative physiology salt from physiological saline cup by suction needle
Water is added in whole blood cup, and opening tumbler makes detection card quickly rotate, and forming centrifugal force makes blood plasma be filled into blood from whole blood cup
Slurry cup；
Step 3：Control suction needle to enter in blood plasma cup and draw quantitative diluted blood plasma, be added in each first reagent cup,
It is again turned on rotating device and rotates detection card back and forth so that sample, reagent mixed liquor in each first reagent cup mix；
Step 4：Control rotating device cause detect card uniform rotation, by detection unit to solution in the first reagent cup into
Row optical detection；
Step 5：Suction needle inner wall is cleaned by diluter, suction needle outer wall is carried out by cleaning unit clear
Wash；
Step 6：Control sampling probe is drawn the second reagent in each second reagent cup and is added in the first reagent cup, opens rotation
Device rotation detection card；
Step 7：Suction needle inner wall is cleaned by diluter, suction needle outer wall is carried out by cleaning unit clear
Wash；
Step:8：Driving detection card at the uniform velocity rotates, and detection unit all carries out the first reagent cup in each swing circle
Multi-wavelength detection, records testing result.
In the present invention, the mode of rotating device rotation detection card is as follows in step 2, step 3 and step 6：One is mixed repeatedly
More than secondary, rotation angle is more than 10 degree.
In the present invention, in detection process, when the first reagent cup detection absorbance OD values are more than 1.6, instrument is automatically to the
Reactant dilution in one reagent cup is resurveyed.、
The system instrument is also equipped with to detection range sample without separately using the i.e. executable automatic dilution check of reagent sample
Function.The sample for being applicable to other fields such as medical treatment, food, environmental protection is quickly analyzed.
Beneficial effect：The present invention can complete to detect with fast and easy, while improve the precision of testing result；And same inspection
Multiple biochemical and immunization program detections can be completed at the same time by surveying on card, can perform double reagent detection, and bales catch removes sample blank；
Instrument only has a detection card rotating disc, is loaded with the reagent and sample all needed, and required wash number is reduced, and
Clean infallible, effectively reduction reagent waste and cross contamination.Dedicated test card is positioned on detection card rotating disc during detection,
And only a pin completes the absorption and distribution of reagent and sample；Instrument detection card rotating disc can drive the quick rotation production of detection card
Raw centrifugal force, while by detecting the filtering of miillpore filter in the upper specimen cup of card, the blood plasma being automatically separated in whole blood.Therefore this hair
It is bright more convenient, more accurate, more economical, more environmentally friendly.
Brief description of the drawings
The present invention is done with reference to the accompanying drawings and detailed description and is further illustrated, it is of the invention above-mentioned or
Otherwise advantage will become apparent.
Fig. 1 is device overall schematic；
Fig. 2 is present invention detection card structure schematic diagram；
Fig. 3 is sample pin and buanch unit schematic diagram；
Fig. 4 is transmitted light and scattering photoreactivation detection device schematic diagram；
Fig. 5 is specimen cup structure diagram；
Fig. 6 detects card structure schematic diagram for embodiment 2
Fig. 7 detects card structure schematic diagram for embodiment 3
Embodiment
Elaborate below in conjunction with attached drawing to the present invention.
Such as Fig. 1, detection card and detector, detector control detection block rotation, and the detector is included at control and data
Manage unit, suction needle and buanch unit, incubate storehouse, detection plate rotary system, detection unit and cleaning unit, at control and data
Manage unit control suction needle and buanch unit, detection plate rotary system, the operation of detection unit and cleaning unit.Suction needle
And buanch unit includes suction needle, diluter and suction needle mobile device, sample pin mobile device includes sample pin moving tube
Road and the first motor, the second motor and the valve being arranged on sample pin movement pipeline, the first motor and the second motor difference
Control suction needle up and down motion and side-to-side movement.
In Fig. 2, specimen cup 2 divides blocks 1 inner ring for whole blood cup 4 and blood plasma cup 3, specimen cup positioned at detection；Set on detection card
There are specimen cup 2, physiology salt cup 5, the first reagent cup 10, the second reagent cup 9 and the cleaning of the first cleaning agent cup 6, second can be contained
Agent cup 7 and cleaning cup 8.Miillpore filter is used for whole blood in filtering whole blood cup, the cell of whole blood is retained wherein, and blood plasma exists
Centrifugal force effect is lower to penetrate into blood plasma cup through miillpore filter；Physiology salt cup pre-installs physiological saline, for being carried out to whole blood
Dilution；First reagent cup pre-installs the first reagent needed for each detection project respectively, and blood plasma is quantified transfer by suction needle during detection
Into the first reagent cup, for carrying out optical detection；Second reagent cup pre-installs the second examination needed for each detection project respectively
The second specified reagent, is transferred in the first reagent cup specified during detection and carried out by agent by suction needle according to detection project requirement
React and detect；The cleaning agent cup pre-installs cleaning agent, for cleaning suction needle；The cleaning cup prepackage deionized water, is used
In cleaning suction needle；Suction needle draws cleaning according to institute's detection object program when needing cleaning into specified cleaning agent cup
Agent, then excludes to service sink, then arrives cleaning cup again and draws ejected wash water, then excludes, realized to suction needle to service sink
Inside and outside cleaning.
The suction needle only one of the system, and undertake the absorption distribution of sample and reagent.It is pre-loaded with the detection card
The required sample of perform detection, various reagents, and projects reaction detection is all completed in first reagent cup of projects, is removed
The required other reagents of each detection project, sample are drawn all by suction needle by each cup of detection card outside first reagent is transferred to the
One reagent cup.
The detector includes control and data processing unit, suction needle and buanch unit, detection plate rotary system, detection
Unit and cleaning unit；The detection plate rotary system is used to drive the quick rotation of detection card, and the miillpore filter in specimen cup
Filtering collaboration under, centrifuge out the blood plasma in whole blood；Control and data processing unit are used between controller unit each unit
Co-ordination, processing detection data simultaneously calculate testing result etc.；
Suction needle and buanch unit are moved by a suction needle, quantitative diluter, connecting line, valve and a suction needle
Dynamic device composition, for adding blood plasma into the first reagent cup, and draws the second reagent quantitative in the second reagent cup and is added to
In corresponding first reagent cup；
Detection unit includes more than one optical detection apparatus, which is arranged at the incubation groove of detector, optics inspection
Surveying device includes light source, photoelectric signal receiver, detection be stuck in electric rotating machine drive it is lower by each first reagent cup in sequence according to
Secondary to pass through test position, instrument is periodically repeatedly detected each first reagent cup in whole detection process one by one.
Suction needle cleaning unit includes pump, connecting line, valve and service sink.
Detection card can also not have physiology salt cup.
Detection card is discoid, and when use is installed on the turntable of detector, and the first reagent cup is all located at detector
Annular is incubated in groove 19, incubates groove 35-45 DEG C of constant temperature of control；The whole blood cup of specimen cup is arranged on the partial center side of detection card,
The blood plasma cup of specimen cup is positioned at detection card partially away from center side.
25 Kong Jing≤10.0 μm of miillpore filter in specimen cup, and the blood plasma cup 3 of specimen cup is deeper than whole blood cup 4, after separation
Blood plasma can not be back in whole blood cup.
Detection card has specific identifier, and detector has the reading device of the automatic identification mark, and detector can pass through
Whether the specific identifier automatic identification detects card information, including detection Card Type, detection project, detection card in the term of validity, each inspection
The sample-adding amount of survey project, be loaded the parameter informations such as flow, testing conditions, standard curve.Particularly, specific identifier can be bar
Code, Quick Response Code or chip；When detection is placed in rotating device, detection strip code is directed at detector recognition area automatically, or manually
Will detection strip code alignment detector recognition area.
The detection card is on the ad hoc turntable of instrument and fixed when using, and motor 20 can driving disc rotation and band
Dynamic detection card 1 thereon rotates；Detecting front motor drives turntable and detection card to rotate at a high speed, through filtering with microporous membrane, by whole blood
Haemocyte is centrifuged with blood plasma in cup so that haemocyte is stayed in whole blood cup, and blood plasma is through filtering with microporous membrane into blood plasma cup；
In detection process, motor uniform rotation, stops after+1 for each revolution, and drawing sample by suction needle adds the first reagent
Cup, or draw the second reagent and be added in corresponding first reagent cup.After sample, reagent are drawn and be assigned, motor is lasting
Do not stop at the uniform velocity rotation, until detection process is completed.
Instrument drives turntable and detection card high speed rotation-emergency stop, repeated multiple times mode so that the first reagent by motor
Cup, the liquid in blood plasma cup cause in cup that liquid repeatedly flow and mix by deflecting due to the change of external force.
Detection blocks each cup and reagent is housed according to setting inside each cup when being supplied to user, and there is diaphragm seal 22 in upper surface.
Such as Fig. 4 a, in the present embodiment, the first incubates side on the side wall of groove 19 and is equipped with light source 23, and opposite side, which is equipped with, to be transmitted
Optical detection device 24；
Such as Fig. 4 b, side is equipped with light source 23 on the side wall of second of incubation groove 19, and the bottom for incubating groove is equipped with scattering light and examines
Survey device 25；
Such as Fig. 4 c, the third incubates side on the side wall of groove 19 and is equipped with light source 23, and opposite side is equipped with transmission optical detection device
24, the bottom for incubating groove is equipped with scattering optical detection device 25, and transmission optical detection device 24 is arranged at detection and blocks each cup non-colinear position
Groove walls, for carrying out transmitted light detection to reagent background in the first reagent cup, reagent sample mixed liquor；Scatter light detection dress
Put 25 and be arranged at the bottom portion of groove that detection blocks each cup non-colinear position, for reagent background, reagent and sample in the first reagent cup
Mixed liquor is scattered light detection.
The present embodiment is using the third incubation groove.
Sample pin and buanch unit operation principle：Such as Fig. 1, the diaphragm seal on detection 1 specimen cup 2 of card is manually torn first
22, quantitative whole blood is drawn from heparin tube 11 and is added in the whole blood cup 4 of specimen cup；Or by separated serum or blood plasma, directly
It is added in the blood plasma cup 3 of detection card；Then detection card is placed on the detection card rotating disc of detector, then reagent cup is placed in ring
Shape is incubated in groove 19, open detection key；First motor 13 and the second motor 14 are controlled above and below suction needle, moved left and right respectively, extremely
The top of physiology salt cup 5, suction needle 12 draw quantitative physiological saline and add whole blood cup through the diaphragm seal on physiology salt cup 5
In, detection card rotating disc quickly rotates, and is filtered through miillpore filter 25, and blood plasma separates repeatedly fast to blood plasma cup 3, detection card in whole blood
Fast rotation-emergency stop mixes diluting plasma.
Such as Fig. 1, instrument suction needle draws quantitative diluting plasma from blood plasma cup 3, and suction needle is each passed through projects first
Diluting plasma, is added in the first reagent cup of projects of detection card by reagent cup 10 respectively, and detection blocks quick rotation-urgency repeatedly
Stop, so realize liquid blending in each first detection cup repeatedly, blood plasma is mixed with pre- the first reagent being mounted in the first reagent cup
After conjunction, the at the uniform velocity rotation of detection card carries out optical detection；Suction needle is transferred to the top of the first cleaning agent cup 6 afterwards, clear through first
Diaphragm seal on lotion cup 6, draws quantitative first cleaning agent, and suction needle is moved to service sink 16 and discharges the clear of the interior suction of suction needle
Lotion, the exterior washings pin 17 of cleaning unit by pump 18, draw ejected wash water in washer bottle 21 wash by water to 12 outer wall of suction needle into
Row cleaning；
Cleaning way includes following several ways：1st, directly inside and outside water cleaning；2nd, cleaning agent 1- is inhaled to rinse；Inhale cleaning agent 2-
Rinse；3rd, water suction cleaning；4th, it can be directed to and inhale types of agents difference using different cleaning ways.
Suction needle is transferred to above the second reagent of projects respectively, is each passed through each diaphragm seal, is drawn projects second and is tried
Agent 9 adds corresponding first reagent cup and simultaneously mixes, and suction needle is drawn after second reagent added in the first reagent cup every, to the
One cleaning agent cup 5 draws quantitative first cleaning agent, is moved to and is arranged on the service sink 16 of detection card side and exhausts, cleaning unit
Exterior washings pin 17 is drawn ejected wash water in washer bottle 21 and the bath of 12 outer wall of suction needle is cleaned by pump 18；Again to second
Cleaning agent cup 6 draws quantitative second cleaning agent, is moved to service sink 16 and exhausts, while pin appearance is cleaned；It is electric during detection
The driving detection card of machine 20 at the uniform velocity rotates, and is needing to draw, distribute the position minibreak of sample and reagent, each swing circle
Middle detection device all carries out a multi-wavelength detection to each reagent cup, records testing result.Draw and distribute in sample and reagent
Cheng Hou, detection clamping continues constant speed rotary until detection terminates, and instrument rotating disc stops rotating.
Disclosed herein as well is another medical quick biochemical detection system and detection method, comprise the following steps：
Step 1：Detection card is placed on the detection card rotating disc of detector, heparin tube is reached under suction needle, presses instrument
Device detects key, and suction needle is drawn quantitative whole blood from heparin tube, is added in the whole blood cup of specimen cup automatically；Or from heparin tube
Separated serum or blood plasma are drawn, is added in the blood plasma cup of detection card；Subsequent suction needle is moved to service sink, cleaning unit
Flushing needle suction needle outer wall is cleaned；Step 2：Suction needle is moved in the whole blood cup of specimen cup, whole blood is added complete
In blood cup, suction needle is drawn quantitative physiological saline from physiological saline cup and is added in whole blood cup afterwards, and detection card rotating disc is quick
Rotation separates blood plasma in whole blood to blood plasma cup, and rotating disc drives detection card again, and quick rotation-emergency stop mixes diluting plasma repeatedly；
Step 3：Instrument suction needle draws quantitative diluted blood plasma from blood plasma cup；Suction needle adds diluting plasma afterwards
Into the first reagent cup of projects of detection card, after each first reagent adds, detection blocks quick rotation-emergency stop repeatedly, due to cup
Middle liquid condition imbalance causes the continuous deflecting flowing of the liquid in the first reagent cup, so mixes repeatedly, makes blood plasma and prepackage
After the first reagent mixing in the first reagent cup, the at the uniform velocity rotation of detection card carries out optical detection；Suction needle is transferred to afterwards
One cleaning agent cup position, draws quantitative first cleaning agent, and then suction needle is moved to the cleaning of suction in service sink discharge suction needle
Agent, and cleaning unit cleans the bath of suction needle inside and outside wall；
Step 4：Suction needle draws the second reagent of projects and is separately added into projects the first reagent cup of correspondence, and suction needle is every
After drawing in the second reagent first reagent cup of addition, suction needle to the first cleaning agent cup draws quantitative cleaning agent, is moved to
Service sink exhausts；
Step 5：Instrument detection card mixes liquid in the first reagent cup repeatedly according to quick rotation-emergency stop mode；
Step 6：Motor driving detection card at the uniform velocity rotates during detection, and in the position for needing to draw, distribute sample and reagent
Minibreak, detection device all carries out a multi-wavelength detection to each reagent cup in each swing circle, records testing result.
After sample, reagent absorption are assigned, detection clamping continues constant speed rotary until detection terminates, and instrument rotating disk is stopped rotating.
A whole blood test cup is also separately provided with the detection card of the present apparatus, wherein prepackage Quantitative Haemolytic agent, people during detection
Work or suction needle add quantitative whole blood blood sample in the whole blood test cup, after blood sample is mixed with hemolyzing reagent dilution haemolysis, measure
Hemoglobin in the cup, according to the ratio and content of red blood cell and blood plasma in the hemoglobin automatic decision blood sample.Due to
Plasma content is different in Different Individual whole blood, and separation obtains plasma volume difference, is obtaining the red blood cell and plasma content of the blood sample
And after the botal blood volume always taken, and liquid measure is diluted according to total add, it is possible to more accurately calculate in the blood plasma in whole blood sample
Each component actual content.Calculation formula：Blood plasma accounts for the ﹣ (hemochrome concentration × factors measured of the volume ratio of whole blood=100%
K when) %, wherein hemochrome concentration unit are g/l, factor K≤30, can calculate K factor during other units according to corresponding proportion.
It is all
Testing result the concentration of various compositions in blood plasma is all calculated according to the plasma volume of addition.
It can judge Plasma volumes by measuring blood sample cell turbidity during the system detectio of the present apparatus.Specific method blocks for detection
On pre-set blood sample cell turbidity detection cup, quantitative physiological saline is pre-installed in cup.Before detection according to detection card request to this
Quantitative whole blood is added in cup and is mixed, when detection card is placed on detector, it is thin that detector first detects addition blood in the cup
Turbidity after born of the same parents, then calculates content of the cell in blood sample, the volume deducted in whole blood after cell content is blood plasma (blood
Content clearly), all testing results all go out the inspection of various compositions in blood plasma (serum) according to actual plasma (serum) content calculation
Survey concentration results.The calculation formula of plasma concentration is：
Coefficient N≤0.1.
Embodiment 2：
Such as Fig. 6, specimen cup is divided into whole blood cup and blood plasma cup, and specimen cup is positioned at detection card outer ring.
Embodiment 3：
Such as Fig. 7, specimen cup is single hole cup, wherein being not previously incorporated any reagent or dilution, receives serum, blood plasma or complete
Blood is not separated and is directly detected.
Embodiment 4：
The specimen cup of detection card is single hole, wherein pre-installing a certain amount of examination with haemolysis and dilution function in advance
Agent, when use, are directly added into a certain amount of whole blood sample in specimen cup, and sample forms haemolysis sample after adding, used after mixing
In detection.
Embodiment 5：
Detection card, which is arranged on, to be incubated in storehouse, i.e., whole detection card and detector are all located at a constant temperature and incubate in storehouse.
Embodiment 6：
In the present invention, when instrument detection reaction solution absorbance OD values are more than more than 1.6 preset value, suction needle is certainly
The dynamic physiological saline drawn in physiology salt cup, is detected, extension rate again after being diluted to reaction solution in corresponding reagent cup
For 0.5-20 times.Instrument calculates acquisition more accurately testing result according to the absorbance after dilution again, new without drawing again
Sample and reagent be diluted and detect again.
According to different detection methods, testing result calculation is different：
A. for biochemical endpoints method, enzyme mark detection method and chemiluminescence detecting method, before dilution after reaction solution concentration=dilution
Reaction solution absorbance × extension rate × COEFFICIENT K 1, wherein K1 for dilution before the coefficient of relationship of reaction solution absorbance and concentration, K1
It is variant according to project difference for 0.1~500 any number, K1 values；
B. detected for biochemical performance rate method and two-point method, reaction solution absorbance after reaction solution concentration=dilution before dilution × dilute
Multiple × K2 is released, wherein K2 is reaction solution concentration and the coefficient of relationship of absorbance/time value before dilution, between K2 is 0.1~3000
Any number, K2 values are variant according to project difference.When performance rate method detects, since time control is inaccurate, acquisition is calculated
As a result not necessarily very accurate, experiment proves that the testing result that this method obtains is far superior to the detection knot that other methods are obtained
Fruit.
Embodiment 7：
Only have a suction needle on detector, sample and reagent are quantified according to needed for detection, in an orderly manner in the detection card
Transfer (mode of existing flowing or diffusion is unable to accurate quantitative analysis) between upper difference cup, detection card can be completed to the more of sample
A item detection.
Embodiment 8：
Detection card is equipped with the second reagent cup, the second reagent needed for prepackage detection project, and when detection will be referred to by suction needle
The second fixed reagent according to detection project required amount and sequential transfer into the first specified reagent cup, through mix react after again
Carry out optical detection.
The present invention provides a kind of medical quick biochemical detection system and detection method, the side of the technical solution is implemented
Method and approach are very much, and the above is only the preferred embodiment of the present invention, it is noted that for the common skill of the art
For art personnel, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications
Also it should be regarded as protection scope of the present invention.All undefined components in this embodiment can be implemented in the prior art.
Claims (10)
1. a kind of medical quick biochemistry detection card device, it is characterised in that described including the detection card on tumbler
Detection card is equipped with more than one reagent cup and specimen cup, is not communicated with independently of each other between each cup；Each reagent cup difference
Reagent needed for each detection project is pre-installed, each detection project at least has first reagent cup, and each detection project is right
Answer and complete to react and detect in the first reagent cup；
Specimen cup is used to place sample, and sample is whole blood, blood plasma or serum.
2. the medical quick biochemistry detection card device of one kind according to claim 1, it is characterised in that set on the detection card
Have the second reagent cup, pre-install the second reagent needed for detection project, during detection by suction needle by the second specified reagent according to inspection
Project demand amount and sequential transfer are surveyed into the first specified reagent cup, optical detection is carried out again after mixing and reacting.
3. the medical quick biochemistry detection card device of one kind according to claim 1, it is characterised in that the detection card is also set
There are cup, cup prepackage distilled water or physiological saline, for cleaning suction needle, dilute sample or reaction solution.
4. the medical quick biochemistry detection card device of one kind according to claim 1, it is characterised in that the detection card is also set
There are cleaning agent cup, cleaning agent cup prepackage cleaning agent, for cleaning suction needle.
5. the medical quick biochemistry detection card device of one kind according to claim 1, it is characterised in that the sample on detection card
Cup prepackage Quantitative Haemolytic agent.
6. the medical quick biochemistry detection card device of one kind according to claim 1, it is characterised in that the specimen cup is double
Hole cup, including two parts being connected of whole blood cup and blood plasma cup, wherein whole blood cup are positioned at the inner side of detection card, and blood plasma cup is positioned at inspection
The outside of card is surveyed, is equipped with miillpore filter between the blood plasma cup and whole blood cup, when use in advance adds blood sample blocks positioned at detection
Detection card, is then installed in detection card rotating disk by the whole blood cup of inner side, utilizes the tumbler centrifugation that rotation is formed at a high speed
Power, drives the blood plasma in blood sample to enter the blood plasma cup for being located at outside by miillpore filter, haemocyte is retained in whole blood cup.
7. a kind of medical quick biochemical detection system, it is characterised in that the system includes detection card and detector, detector control
Detection blocks rotation, and the detector includes control and data processing unit, suction needle and buanch unit, incubates storehouse, detects and spiral
Transfer from one department to another system, detection unit and cleaning unit, control and data processing unit control suction needle and buanch unit, detection disc spins system
The operation of system, detection unit and cleaning unit.
8. the medical quick biochemical detection system of one kind according to claim 7, it is characterised in that suction needle cleaning unit bag
Cleaning pipes and the pump being arranged in Cleaning pipes are included, Cleaning pipes both ends are respectively washed pin and cleaning water bottle, clean water bottle
In be placed with ejected wash water, cleaning needle lower end is equipped with service sink.
9. a kind of detection method of medical quick biochemical detection system, it is characterised in that detection card is equipped with physiology salt cup, examines
The sample of survey is quantitative serum or blood plasma, and suction needle first draws quantitative physiological saline and is directly added into sample in detection process
Cup, dilutes sample and mixes, then rationed to each first reagent cup of pipette samples, is detected.
10. a kind of detection method of medical quick biochemical detection system, it is characterised in that include the following steps：
Step 1：Take quantitative whole blood to be added in the whole blood cup of specimen cup, and whole blood cup is placed on detection card；
Step 2：Detection card is placed on tumbler, drawing quantitative physiological saline from physiological saline cup by suction needle adds
Enter in whole blood cup, opening tumbler makes detection card quickly rotate, and forming centrifugal force makes blood plasma be filled into blood plasma cup from whole blood cup；
Step 3：Control suction needle to enter in blood plasma cup and draw quantitative diluted blood plasma, be added in each first reagent cup, again
Open rotating device and rotate detection card back and forth so that sample, reagent mixed liquor in each first reagent cup mix；
Step 4：Control rotating device to detect card uniform rotation, by detection unit to solution progress light in the first reagent cup
Learn detection；
Step 5：Suction needle inner wall is cleaned by diluter, suction needle outer wall is cleaned by cleaning unit；
Step 6：Control sampling probe is drawn the second reagent in each second reagent cup and is added in the first reagent cup, opens rotating device
Rotation detection card；
Step 7：Suction needle inner wall is cleaned by diluter, suction needle outer wall is cleaned by cleaning unit；Step
Suddenly:8：Driving detection card at the uniform velocity rotates, and detection unit all carries out a multi-wavelength in each swing circle to the first reagent cup
Detection, records testing result.
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| PCT/CN2018/081097 WO2019127958A1 (en) | 2017-12-26 | 2018-03-29 | Medical rapid biochemical detection system and detection method |
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| CN110879292A (en) * | 2019-11-29 | 2020-03-13 | 重庆大学 | Blood physical and chemical analysis method |
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| CN112213509A (en) * | 2020-09-30 | 2021-01-12 | 宁波美康盛德生物科技有限公司 | Automatic application of sample system of reaction tube |
| CN112557648A (en) * | 2020-12-25 | 2021-03-26 | 重庆康巨全弘生物科技有限公司 | POCT fluorescence immunoassay appearance |
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| CN107966578B (en) | 2024-01-02 |
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