CN109806199B - Whitening skin care composition and preparation method thereof - Google Patents
Whitening skin care composition and preparation method thereof Download PDFInfo
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- CN109806199B CN109806199B CN201910210226.7A CN201910210226A CN109806199B CN 109806199 B CN109806199 B CN 109806199B CN 201910210226 A CN201910210226 A CN 201910210226A CN 109806199 B CN109806199 B CN 109806199B
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- nonapeptide
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Abstract
The invention discloses a whitening skin care composition and a preparation method thereof, wherein the composition comprises the following components: sulforaphane, nonapeptide-1, palmitoyl tripeptide-5, trehalose and cactus extract; wherein the weight ratio of the sulforaphane to the nonapeptide-1 to the palmitoyl tripeptide-5 to the trehalose is (5-10): (5-10): (5-10): (70-85); the sulforaphane, the nonapeptide-1, the palmitoyl tripeptide-5 and the trehalose are prepared into freeze-dried powder. The composition has remarkable whitening effect and better moisturizing effect through the synergistic effect among the compositions.
Description
Technical Field
The invention relates to a skin care composition, and particularly relates to a whitening skin care composition and a preparation method thereof.
Background
Melanin is a protein present in the basal layer of the skin of everyone. The irradiation of ultraviolet rays can change melanin to generate a substance for protecting skin, and then the melanin moves layer by layer through cell metabolism to reach the epidermis layer of the skin, so that the skin problems of color spots, uneven skin color and the like seen by people are formed. The whitening skin care product can help improve the condition of skin, such as a whitening product containing nicotinamide as a main ingredient, which can help the skin to inhibit and regulate the transfer of melanin, and reduce the formed color spots.
Currently, the existing whitening agents are: arbutin, kojic acid, niacinamide, etc., although having a whitening effect, have some disadvantages. For example, arbutin has poor stability, and kojic acid, niacinamide, etc. have certain skin irritation.
Disclosure of Invention
The invention aims to provide a whitening skin care composition and a preparation method thereof, the composition solves the problem of blackening of skin color and has an obvious whitening effect.
In order to achieve the above objects, the present invention provides a whitening skin care composition comprising: sulforaphane, nonapeptide-1, palmitoyl tripeptide-5, trehalose and cactus extract; wherein the weight ratio of the sulforaphane to the nonapeptide-1 to the palmitoyl tripeptide-5 to the trehalose is (5-10): (5-10): (5-10): (70-85); the sulforaphane, the nonapeptide-1, the palmitoyl tripeptide-5 and the trehalose are prepared into freeze-dried powder.
Preferably, the mass ratio of the sulforaphane, the nonapeptide-1, the palmitoyl tripeptide-5 and the trehalose is 1: 1: 1: (7-8.5).
Preferably, the mass fraction of the cactus extract is 15-20%.
The invention also provides a preparation method of the whitening and skin-care composition, which comprises the following steps:
(1) the weight ratio is (5-10): (5-10): (5-10): (70-85) dissolving the sulforaphane, the nonapeptide-1, the palmitoyl tripeptide-5 and the trehalose in water, filtering for sterilization, carrying out vacuum freeze drying to obtain powder, and packaging to obtain freeze-dried powder;
(2) extracting radix et caulis Opuntiae Dillenii, concentrating the extractive solution, filtering to remove bacteria to obtain radix et caulis Opuntiae Dillenii extractive solution, and packaging;
(3) in application, the lyophilized powder and radix et caulis Opuntiae Dillenii extractive solution are mixed.
Preferably, in steps (1) and (2), membrane filtration sterilization is employed.
Preferably, the pore size of the filtration membrane is 0.22 μm.
Preferably, the mass ratio of the sulforaphane, the nonapeptide-1, the palmitoyl tripeptide-5 and the trehalose is 1: 1: 1: (7-8.5).
Preferably, in step (2), the pulverized cactus is extracted by heating in water.
Preferably, the heating temperature is 50 ℃.
Preferably, the using amount of the cactus is 1.5-2 kg.
The whitening skin care composition and the preparation method thereof solve the problem of blackening skin color and have the following advantages:
according to the composition, the trehalose has a moisturizing effect and has a moisturizing function on skin; the sulforaphane has tyrosinase inhibiting activity and whitening effect; nonapeptide-1 and MC1 receptor on melanocyte have good matching property, can be used as antagonist of melanocyte stimulating hormone, competitively combine with MC1 receptor, prevent tyrosinase from being further activated to generate melanin, nonapeptide-1 competitively seals the entrance of receptor on melanocyte and various factor signals, weakens the activity of melanocyte, reduces the generation amount of melanin, can obviously brighten skin color, and presents ruddy and white skin; palmitoyl tripeptide-5 can inhibit the generation of melanin by inhibiting tyrosinase activity and reducing mRNA levels of MITF and tyrosinase; the cactus extractive solution has obvious whitening effect. The aim of whitening is achieved through the combination.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A skin care composition having whitening efficacy, comprising: the preparation method comprises the following steps of preparing solid-phase freeze-dried powder from 5-10 parts of sulforaphane, 5-10 parts of nonapeptide-1, 5-10 parts of palmitoyl tripeptide-5 and 85 parts of trehalose, dissolving the solid-phase freeze-dried powder with a liquid-phase cactus extracting solution before use, wherein the mass volume fraction of the cactus extracting solution is 15% (namely 1.5 kg of cactus is prepared into 10000mL of extracting solution), and specifically comprises the following steps:
(1) according to the formula, 500mg of glucoraphanin, 500mg of nonapeptide-1, 500mg of palmitoyl tripeptide-5 and 8500mg of trehalose are fully dissolved by 1000mL of distilled water, membrane filtration sterilization with the pore diameter of 0.22 mu m is adopted, then the materials are evenly distributed in 1000 sterilized penicillin bottles, and the bottles are frozen and dried into powder in vacuum, and then the bottles are covered for storage;
(2) according to the formula, 1.5 kg of cactus is crushed, 15 kg of distilled water is used for extracting for 1-2 hours at 50 ℃ to obtain an extracting solution, then the extracting solution is concentrated to 10000mL, membrane filtration sterilization with the aperture of 0.22 mu m is adopted, and then the extracting solution is evenly distributed into 1000 sterilized penicillin bottles and is covered for storage;
(3) when in use, the cactus extract is poured into a freeze-dried powder bottle, shaken up, dissolved completely and smeared on the skin.
Example 2
A skin care composition having whitening efficacy, comprising: sulforaphane, nonapeptide-1, palmitoyl tripeptide-5, trehalose and a cactus extracting solution, wherein 8 parts of sulforaphane, 8 parts of nonapeptide-1, 8 parts of palmitoyl tripeptide-5 and 76 parts of trehalose are prepared into solid-phase freeze-dried powder, the solid-phase freeze-dried powder is dissolved in the liquid-phase cactus extracting solution before use, and the mass volume fraction of the cactus extracting solution is 20% (namely 2 kilograms of cactus are prepared into 10000mL extracting solution).
The preparation method of the skin care composition with the whitening effect comprises the following specific steps:
(1) according to the formula, 800mg of glucoraphanin, 800mg of nonapeptide-1, 800mg of palmitoyl tripeptide-5 and 7600mg of trehalose are fully dissolved by 1000mL of distilled water, membrane filtration sterilization with the pore diameter of 0.22 mu m is adopted, then the materials are evenly distributed in 1000 penicillin bottles, and the penicillin bottles are frozen and dried into powder in vacuum, and then the penicillin bottles are covered and stored;
(2) according to the formula, 2 kg of cactus is crushed, 20 kg of distilled water is used for extracting for 2 hours at 50 ℃ to obtain an extracting solution, then the extracting solution is concentrated to 10000mL, membrane filtration sterilization with the aperture of 0.22 mu m is adopted, and then the extracting solution is averagely distributed into 1000 penicillin bottles and is stored by being covered;
(3) when in use, the cactus extract is poured into a freeze-dried powder bottle, shaken up, dissolved completely and smeared on the skin.
The composition of the invention has the following specific functions of the components:
(1) the trehalose has the function of moisturizing and has the function of moisturizing the skin;
(2) the sulforaphane has tyrosinase inhibiting activity and whitening effect;
(3) nonapeptide-1 has good matching property with MC1 (melanocortin receptor 1) receptor on melanocyte, thus can be used as an antagonist of melanocyte stimulating hormone, competitively combines with MC1 receptor, prevents tyrosinase from being further activated to generate melanin, and the nonapeptide-1 competitively seals the entrance of receptor on melanoblast and signals of various factors, weakens the activity of melanoblast, reduces the melanin generation amount, can obviously brighten skin color, and presents ruddy and white skin;
(4) palmitoyl tripeptide-5 can inhibit the generation of melanin by inhibiting tyrosinase activity to down-regulate mRNA levels of MITF (Microphthalmia-associated transcription factor) and tyrosinase;
(5) the cactus extractive solution has obvious whitening effect.
Through the combination, the whitening cream can achieve a good whitening effect.
Experimental example 1
The skin whitening and caring product prepared in the embodiment 1 of the invention is subjected to human skin tests, and specifically comprises the following steps:
20 male college students and 20 female college students were selected, the skin of 1 square centimeter of neck was used as the experimental part, the other part was the control area, the composition of the present invention was applied to the experimental part 3 times a day, morning, evening, and the experimental part was not applied with any cosmetics, the application was continued for 10, 15, 20, 25, and 30 days, the whitening effect of the control area of the applied part and the nape where no sample was applied was observed, and the change in the melanin content in the skin was measured.
The smeared part and the control area are compared, and the difference of the skin color is larger along with the longer smearing time, the smeared part is obviously whiter than the control area, and the melanin content is obviously reduced for the longer time, which shows that the composition has the whitening effect.
Experimental example 2
The experimental method of the comparative whitening effect test of the composition of the present invention and the individual components (sulforaphane, nonapeptide-1 and palmitoyl tripeptide-5) was substantially the same as that of the above experimental example 1, 20 female college students were selected, skin of 1 square centimeter at the neck of the same subject was selected as the experimental part, the composition of the present invention, sulforaphane, nonapeptide-1 and palmitoyl tripeptide-5 at the same concentration were applied to 5 experimental parts, respectively, and sulforaphane, nonapeptide-1 and palmitoyl tripeptide-5 were dissolved using cactus extract, and continuously applied for 30 days, the whitening effect of the control area of the applied part and the back neck where no sample was applied was observed, and the change of melanin content in the skin was measured.
Comparing 5 smearing parts, the skin color of the part smeared with the composition is obviously white compared with that of other 4 smearing parts, and the melanin content of the part smeared with the composition is also obviously low by measuring the melanin content, which shows that the whitening effect of the composition is better than that of a single component, and the components have synergistic action.
Experimental example 3
The moisturizing effect of the composition of the present invention was measured:
the skin whitening and caring product prepared in the embodiment 1 of the invention is subjected to human skin tests, and specifically comprises the following steps:
20 female college students are selected, skin with 1 square centimeter at 3 parts of the neck is selected as an experimental part, the composition is applied to the experimental part, no cosmetic can be applied to the experimental part, the change of the moisture content on the surface of the skin is measured by measuring the change of the capacitance of the horny layer of the skin before and after the application, and the moisture content of 1h, 2h, 3h, 4h, 5h, 6h, 7h and 8h is measured.
The determination shows that the moisture content is higher at 1h, and the moisture content is reduced along with the longer time, but the moisture content is obviously higher than that before smearing.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.
Claims (9)
1. A whitening skin care composition, comprising: sulforaphane, nonapeptide-1, palmitoyl tripeptide-5, trehalose and cactus extract; wherein the weight ratio of the sulforaphane to the nonapeptide-1 to the palmitoyl tripeptide-5 to the trehalose is (5-10): (5-10): (5-10): (70-85); the sulforaphane, the nonapeptide-1, the palmitoyl tripeptide-5 and the trehalose are prepared into freeze-dried powder;
the preparation method of the composition comprises the following steps:
(1) the weight ratio is (5-10): (5-10): (5-10): (70-85) dissolving the sulforaphane, the nonapeptide-1, the palmitoyl tripeptide-5 and the trehalose in water, filtering for sterilization, carrying out vacuum freeze drying to obtain powder, and packaging to obtain freeze-dried powder;
(2) extracting pulverized radix et caulis Opuntiae Dillenii in water under heating, concentrating the extractive solution, filtering to remove bacteria to obtain radix et caulis Opuntiae Dillenii extractive solution, and packaging;
(3) in application, the lyophilized powder and radix et caulis Opuntiae Dillenii extractive solution are mixed.
2. The whitening skin care composition according to claim 1, wherein the sulforaphane, the nonapeptide-1, the palmitoyl tripeptide-5 and the trehalose are in a mass ratio of 1: 1: 1: (7-8.5).
3. The whitening and skin-care composition according to claim 1 or 2, wherein the mass fraction of the cactus extract is 15-20%.
4. A method of preparing the whitening and skin care composition of claim 1, comprising the steps of:
(1) the weight ratio is (5-10): (5-10): (5-10): (70-85) dissolving the sulforaphane, the nonapeptide-1, the palmitoyl tripeptide-5 and the trehalose in water, filtering for sterilization, carrying out vacuum freeze drying to obtain powder, and packaging to obtain freeze-dried powder;
(2) extracting pulverized radix et caulis Opuntiae Dillenii in water under heating, concentrating the extractive solution, filtering to remove bacteria to obtain radix et caulis Opuntiae Dillenii extractive solution, and packaging;
(3) in application, the lyophilized powder and radix et caulis Opuntiae Dillenii extractive solution are mixed.
5. The method for preparing a whitening skin care composition according to claim 4, characterized in that in the steps (1) and (2), membrane filtration sterilization is adopted.
6. The method of preparing a whitening skin care composition according to claim 5, wherein the membrane has a pore size of 0.22 μm.
7. The method for preparing the whitening and skin-care composition according to claim 4, wherein the mass ratio of the glucoraphanin to the nonapeptide-1 to the palmitoyl tripeptide-5 to the trehalose is 1: 1: 1: (7-8.5).
8. The method for preparing the whitening skin care composition according to claim 4, wherein the heating temperature is 40-60 ℃.
9. The preparation method of the whitening and skin-care composition according to any one of claims 4 to 8, wherein the cactus is used in an amount of 1.5 to 2 kg.
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| US10172772B2 (en) * | 2013-01-31 | 2019-01-08 | KGK Science, Inc. | Methods of skin whitening by use of canola extracts |
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| CN101534810A (en) * | 2006-10-17 | 2009-09-16 | 株式会社林原生物化学研究所 | Antiinflammatory agent comprising 2-aminophenol or derivative thereof as active ingredient |
| CN103462867A (en) * | 2013-09-05 | 2013-12-25 | 浙江大学 | Preparation method of silk glue/trehalose skin-care facial mask |
| JP2018002702A (en) * | 2016-06-22 | 2018-01-11 | オリザ油化株式会社 | Carbonylation inhibitor |
| CN109010096A (en) * | 2018-09-20 | 2018-12-18 | 北京原肽干细胞医学研究院有限公司 | A kind of deep layer maintenance Essence and preparation method thereof and application method |
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