CN109803971B - 用作prmt5抑制剂的单环和双环系统取代的卡巴核苷类似物 - Google Patents

用作prmt5抑制剂的单环和双环系统取代的卡巴核苷类似物 Download PDF

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CN109803971B
CN109803971B CN201780061258.4A CN201780061258A CN109803971B CN 109803971 B CN109803971 B CN 109803971B CN 201780061258 A CN201780061258 A CN 201780061258A CN 109803971 B CN109803971 B CN 109803971B
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ring
membered
aromatic ring
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CN109803971A (zh
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吴同飞
D.布瑞梅
L.贝克
A.博伊克斯
G.S.M.迪厄斯
E.C.罗森
L.梅尔波尔
V.潘德
M.C.B.C.普拉德
W.B.G.舍朋斯
孙维梅
J.W.J.F.楚林
M.维勒沃耶
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Janssen Pharmaceutica NV
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CN201780061258.4A 2016-10-03 2017-10-02 用作prmt5抑制剂的单环和双环系统取代的卡巴核苷类似物 Active CN109803971B (zh)

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US201662403336P 2016-10-03 2016-10-03
US62/403336 2016-10-03
EP17157785.1 2017-02-24
EP17157785 2017-02-24
PCT/EP2017/074983 WO2018065365A1 (en) 2016-10-03 2017-10-02 Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114057815B (zh) * 2015-08-26 2025-02-25 詹森药业有限公司 作为prmt5抑制剂的、新颖6-6二环芳环取代的核苷

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017338269B2 (en) 2016-10-03 2021-03-25 Janssen Pharmaceutica Nv Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as PRMT5 inhibitors
WO2018154104A1 (en) 2017-02-27 2018-08-30 Janssen Pharmaceutica Nv Use of biomarkers in identifying cancer patients that will be responsive to treatment with a prmt5 inhibitor
BR112020010815A2 (pt) 2017-12-08 2020-11-10 Janssen Pharmaceutica Nv análogos espirobicíclicos
WO2019219805A1 (en) * 2018-05-16 2019-11-21 Ctxone Pty Ltd Combination therapy
TW202112375A (zh) 2019-06-06 2021-04-01 比利時商健生藥品公司 使用ｐｒｍｔ５抑制劑治療癌症之方法
EP4031555A1 (en) * 2019-09-18 2022-07-27 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
CN115135651A (zh) * 2019-12-03 2022-09-30 鲁皮恩有限公司 作为prmt5抑制剂的被取代的核苷类似物
CN113186153B (zh) * 2021-04-15 2023-09-08 南方医科大学 Prmt5抑制剂在促进精原干细胞损伤再生和增殖中的应用
CN113234079B (zh) * 2021-04-30 2022-02-01 上海湃隆生物科技有限公司 用作prmt5抑制剂的核苷类似物
CN114740108B (zh) * 2022-03-28 2023-07-14 天津键凯科技有限公司 一种聚合物修饰抗体类药物的修饰度的测定方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040686A1 (en) * 1995-06-07 1996-12-19 Abbott Laboratories Heterocyclic substituted cyclopentane compounds
WO2003074083A1 (en) * 2002-03-04 2003-09-12 Pfizer Inc. Combination therapies for treating methylthioadenosine phosphorylase deficient cells
WO2015200680A2 (en) * 2014-06-25 2015-12-30 Epizyme, Inc. Prmt5 inhibitors and uses thereof
WO2016135582A1 (en) * 2015-02-24 2016-09-01 Pfizer Inc. Substituted nucleoside derivatives useful as anticancer agents
WO2017032840A1 (en) * 2015-08-26 2017-03-02 Janssen Pharmaceutica Nv Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as prmt5 inhibitors

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224438A (en) 1970-07-14 1980-09-23 Boehringer Mannheim Gmbh Adenosine-5'-carboxylic acid amides
AU2002351077A1 (en) 2001-11-05 2003-05-19 Exiqon A/S Oligonucleotides modified with novel alpha-l-rna analogues
US7034147B2 (en) 2001-11-29 2006-04-25 Irm Llc Nucleoside analog libraries
US7144871B2 (en) 2002-02-19 2006-12-05 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
AU2002951247A0 (en) 2002-09-06 2002-09-19 Alchemia Limited Compounds that interact with kinases
WO2005005450A1 (ja) 2003-07-15 2005-01-20 Mitsui Chemicals, Inc. 環状ビスジヌクレオシドの合成方法
AU2004311702A1 (en) 2003-12-19 2005-07-21 Koronis Pharmaceuticals, Inc. Mutagenic heterocycles
EP1844062A2 (en) 2005-01-21 2007-10-17 Methylgene, Inc. Inhibitors of dna methyltransferase
WO2008001101A2 (en) 2006-06-29 2008-01-03 Astex Therapeutics Limited Pharmaceutical combinations
US20080132525A1 (en) 2006-12-04 2008-06-05 Methylgene Inc. Inhibitors of DNA Methyltransferase
US8962580B2 (en) 2008-09-23 2015-02-24 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
SG181703A1 (en) 2009-12-18 2012-07-30 Harvard College Beta-cell replication promoting compounds and methods of their use
US9145438B2 (en) 2010-12-03 2015-09-29 Epizyme, Inc. 7-deazapurine modulators of histone methyltransferase, and methods of use thereof
US9029343B2 (en) 2010-12-03 2015-05-12 Epizyme, Inc. Modulators of histone methyltransferase, and methods of use thereof
EP2651885A1 (en) 2010-12-16 2013-10-23 Abbvie Inc. Anti-viral compounds
EP2694524B1 (en) 2011-04-04 2016-05-18 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services 2'-o-aminooxymethyl nucleoside derivatives for use in the synthesis and modification of nucleosides, nucleotides and oligonucleotides
JO3154B1 (ar) 2011-06-17 2017-09-20 Glaxosmithkline Llc عوامل مضادة لـ trpv4
JP2014530910A (ja) 2011-10-24 2014-11-20 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｎｏ．２ Ｌｉｍｉｔｅｄ 新規化合物
WO2013151975A1 (en) 2012-04-02 2013-10-10 Northeastern University Compositions and methods for the inhibition of methyltransferases
WO2014035140A2 (en) 2012-08-30 2014-03-06 Kainos Medicine, Inc. Compounds and compositions for modulating histone methyltransferase activity
US20140100184A1 (en) 2012-08-31 2014-04-10 Baylor College Of Medicine Selective inhibitors of histone methyltransferase dot1l
JP2016505000A (ja) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
WO2014100716A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
JP2016505002A (ja) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用
US9604930B2 (en) 2012-12-21 2017-03-28 Epizyme, Inc. Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
EP2975938A4 (en) 2013-03-15 2017-02-15 Ohio State Innovation Foundation Inhibitors of prmt5 and methods of their use
CA2935944A1 (en) 2014-01-09 2015-07-16 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Substituted benzoxazine and related compounds
NZ728162A (en) 2014-07-01 2023-06-30 Takeda Pharmaceuticals Co Heteroaryl compounds useful as inhibitors of sumo activating enzyme
AU2017230658B2 (en) 2016-03-10 2021-03-04 Janssen Pharmaceutica Nv Substituted nucleoside analogues for use as PRMT5 inhibitors
AU2017338269B2 (en) 2016-10-03 2021-03-25 Janssen Pharmaceutica Nv Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as PRMT5 inhibitors
WO2018065365A1 (en) 2016-10-03 2018-04-12 Janssen Pharmaceutica Nv Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors
WO2018154104A1 (en) 2017-02-27 2018-08-30 Janssen Pharmaceutica Nv Use of biomarkers in identifying cancer patients that will be responsive to treatment with a prmt5 inhibitor
BR112020010815A2 (pt) 2017-12-08 2020-11-10 Janssen Pharmaceutica Nv análogos espirobicíclicos

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040686A1 (en) * 1995-06-07 1996-12-19 Abbott Laboratories Heterocyclic substituted cyclopentane compounds
WO2003074083A1 (en) * 2002-03-04 2003-09-12 Pfizer Inc. Combination therapies for treating methylthioadenosine phosphorylase deficient cells
WO2015200680A2 (en) * 2014-06-25 2015-12-30 Epizyme, Inc. Prmt5 inhibitors and uses thereof
WO2016135582A1 (en) * 2015-02-24 2016-09-01 Pfizer Inc. Substituted nucleoside derivatives useful as anticancer agents
WO2017032840A1 (en) * 2015-08-26 2017-03-02 Janssen Pharmaceutica Nv Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as prmt5 inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Design, synthesis, and biological evaluation of novel human 5"-deoxy-5"-methylthioadenosine phosphorylase(MTAP) substrates;Pei-Pei Kung et al.;《Bioorganic & Medicinal Chemistry Letters》;20050504;第15卷(第2005期);第2829-2833页 *
蛋白质精氨酸甲基化修饰在糖代谢调节中的作用;孙佳颖等;《中国生物化学与分子生物学报》;20111130;第27卷(第11期);第993-997页 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114057815B (zh) * 2015-08-26 2025-02-25 詹森药业有限公司 作为prmt5抑制剂的、新颖6-6二环芳环取代的核苷

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CN115626935B (zh) 2025-07-15
BR112019006414A2 (pt) 2019-06-25
JP2022084699A (ja) 2022-06-07
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CN109803971A (zh) 2019-05-24
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UA124074C2 (uk) 2021-07-14
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