CN109793766A - The preparation method and applications of Gotu Kola oral solution - Google Patents
The preparation method and applications of Gotu Kola oral solution Download PDFInfo
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- CN109793766A CN109793766A CN201910250686.2A CN201910250686A CN109793766A CN 109793766 A CN109793766 A CN 109793766A CN 201910250686 A CN201910250686 A CN 201910250686A CN 109793766 A CN109793766 A CN 109793766A
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Abstract
The invention discloses a kind of preparation method and applications of Gotu Kola oral solution, after this method adds water to cook Gotu Kola, filtering, the first concentrate is obtained, after ethanol water is added into the first concentrate, is stood for 24 hours, take filtrate, it is concentrated and is recycled ethyl alcohol, obtains clear cream, then into clear cream after addition dehydrated alcohol, go stratification, filtering, concentration after supernatant, stratification after water is added, takes after supernatant filtering plus water mix, is canned, sterilizing, obtains Gotu Kola oral solution.The present invention extracts clear cream made from heating concentration as dehydrated alcohol, water is dissolved in after obtaining being soluble in the Thunder God root extract in dehydrated alcohol, and pass through multiple stratification, it is filtered after taking supernatant, Gotu Kola oral solution is obtained, greatly simplifies the preparation process of Gotu Kola oral solution, the method reduce the probability that organic solution is mixed into product and polluted product, and dehydrated alcohol involved in this method is easy to remove and collect, and can recycle and save production cost.
Description
Technical field
The present invention relates to Chinese medicine preparation fields.It is more particularly related to a kind of preparation side of Gotu Kola oral solution
Method and its application.
Background technique
Throat is the portal of lung stomach, has sore throat mostly to contain to stop up because of wind fire phlegm and closes throat and the lung stomach cold of insufficiency type or lung and stomach excessive heat
Etc. causing, patient's condition racing becomes faster, general rules do not hurt, pain is not unreasonable unsmooth through QI-blood circulation.Sphagitis is larynx section common disease, more
It sends out in the middle-aged and the old, also often hair is in the adult male of thermophilic tobacco and wine, and clinical manifestation is dry for bottleneck throat, swelling and pain of itching, mouth parched and tongue scorched,
Dysphagia etc..Sphagitis will cause detrimental effect to human body talk contacts, diet, work etc..
Gotu Kola is cold in nature bitterly, have it is clearing heat and detoxicating, dampness removing is treating stranguria, inducing diuresis and reducing edema, to treatment jaundice with damp-heat pathogen, heatstroke abdomen
It rushes down, sand leaching blood strangury, carbuncle sore tumefacting virus, injury from falling down, exogenous disease hot summer weather, affection of exogenous wind-heat have good curative effect.Gotu Kola mostly conduct at present
Adminicle addition prepares some traditional Chinese medicinal components, and effect that Gotu Kola is clearing heat and detoxicating, inducing diuresis and reducing edema cannot be promoted and applied widely.
Summary of the invention
It is an object of the invention to solve at least the above problems, and provide the advantages of at least will be described later.
It is an object of the present invention to provide a kind of preparation method and applications of Gotu Kola oral solution, this method is by Thunder God
After root adds water to cook, filtering obtains the first concentrate, after ethanol water is added into the first concentrate, stands for 24 hours, takes filtrate,
It is concentrated and is recycled ethyl alcohol, obtains clear cream, then goes stratification, filtering, concentration after supernatant after addition dehydrated alcohol into clear cream,
Stratification after water is added, takes after supernatant filtering plus water mix, is canned, sterilizing, obtains Gotu Kola oral solution.The present invention is logical
It crosses dehydrated alcohol clear cream obtained is concentrated to heating and extract, obtain being soluble in molten after the Thunder God root extract in dehydrated alcohol
Yu Shui, and pass through multiple stratification, it is filtered after taking supernatant, obtains Gotu Kola oral solution, it is oral to greatly simplify Gotu Kola
The preparation process of liquid, the method reduce the probability that organic solution is mixed into product and polluted product, and nothing involved in this method
Water-ethanol is easy to remove and collect, and can recycle and save production cost.
In order to realize purposes and other advantages according to the present invention, a kind of preparation method of Gotu Kola oral solution is provided,
Include:
S1, Gotu Kola is placed in 50-60 DEG C of water and impregnates 30-40min taking-up, placed into ice water after impregnating 2-4h,
It adds water to cook, obtains mixed liquor, filtered after mixed liquor is placed in 5-10 DEG C of standing 20-40min, obtain the first concentrate, it is dense to first
After the ethanol water that mass fraction is 80% is added in contracting liquid, filtering for 24 hours is stood, heating after filtrate is taken to be concentrated to give clear cream, the
The weight ratio of one concentrate and ethanol water is 5:1；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, filters, obtains after taking supernatant
Second concentrate is placed under 300-500MHz microwave after being concentrated into clear cream by the second concentrate, and water is added, stands after mixing evenly
Layering, filters after taking supernatant, obtains third concentrate, wherein clear cream and the weight ratio of dehydrated alcohol are 3:7 in step S1；
S3, third concentrate is placed at 0-4 DEG C after stratification, is filtered after taking supernatant plus water mixes, is canned, going out
Bacterium obtains Gotu Kola oral solution；
Additionally provide the preparation method preparation of Gotu Kola oral solution described in one kind for treating acute and chronic pharyngitis
Gotu Kola oral solution.
It is preferential, the preparation method of the Gotu Kola oral solution, in step S3 third concentrate stratification it
Before be also added into sucrose, the weight ratio of third concentrate and sucrose is 10:3.
Preferential, the preparation method of the Gotu Kola oral solution is clear in clear cream and step S2 obtained in step S1
The relative density of cream is 1.15-1.20.
Preferential, the preparation method of the Gotu Kola oral solution decocts point 2 progress in S1, decocts 40- every time
80min collects the first decoction liquor after the 1st decoction, adds and carries out the 2nd time after decocting with the water of the weight such as the first decoction liquor,
The second decoction liquor is collected, merges the first decoction liquor and the second decoction liquor, obtains mixed liquor.
Preferential, the preparation method of the Gotu Kola oral solution, Gotu Kola impregnates it before decoction in step S1
It also needs to be immersed in the ultrasonication 30-60min being placed in water at 40-50 DEG C with 20-50kHz afterwards, then is placed at 55-70 DEG C
It after drying 20-40min, crushes, crosses 100-120 mesh.
Preferential, the preparation method of the Gotu Kola oral solution, Gotu Kola impregnates it before decoction in step S1
Also need afterwards be added with Gotu Kola weight ratio be 7:1 antioxidant, antioxidant the preparation method is as follows:
Q1, the race for taking 100-150 parts by weight, the Guava Leaf of 100-200 parts by weight, 200-400 parts by weight orange
Skin, 100-200 parts by weight wheat embryo be respectively washed clean, drying after, be uniformly mixed, obtain mixture；
Q2, mixture is placed in 140-200 DEG C of temperature and pressure 1.06-1.08Mpa steam extraction 2-4h, collects water
It is cooling after steam, distillate is obtained, the ethyl alcohol that the mass fraction that 1200-1800 parts by weight are added into distillate is 70% is water-soluble
Liquid is placed at 40-50 DEG C after handling 20-40min with the revolving speed of 200-300r/min, and stratification takes upper liquid, must extract
Liquid；
Q3, extract liquor is placed in concentration at 50-60 DEG C, is dry, obtaining solid powder, as antioxidant.
It is preferential, the preparation method of the Gotu Kola oral solution, in step S2 clear cream before dehydrated alcohol is added,
Also need that cane leaves, wild chrysanthemum, the leaf of bamboo are added, wherein clear cream and cane leaves, wild chrysanthemum, the leaf of bamboo weight ratio be 9:2:1:2.
The present invention is include at least the following beneficial effects: the present invention in by dehydrated alcohol to heating be concentrated made from clear cream into
Row extracts, and is dissolved in water after having obtained being soluble in the Thunder God root extract in dehydrated alcohol, and pass through multiple stratification, takes supernatant
It is filtered after liquid, obtains Gotu Kola oral solution, greatly simplify the preparation process of Gotu Kola oral solution, be suitable for large-scale production,
The method reduce the probability that organic solution is mixed into product and polluted product, and dehydrated alcohol involved in this method is easy to remove
And collection, can Reusability, to save production cost.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Specific embodiment
The present invention will be further described in detail below with reference to the embodiments, to enable those skilled in the art referring to specification
Text can be implemented accordingly.
It should be noted that experimental method described in following embodiments is unless otherwise specified conventional method, it is described
Reagent and material commercially obtain unless otherwise specified.
Embodiment 1:
The preparation method of Gotu Kola oral solution, comprising:
S1, Gotu Kola is placed in 50 DEG C of water and impregnates 30min taking-up, placed into ice water after impregnating 2h, add water to cook,
Mixed liquor is obtained, is filtered after mixed liquor is placed in 5 DEG C of standing 20min, obtains the first concentrate, quality point is added into the first concentrate
After number is 80% ethanol water, filtering for 24 hours is stood, heating after filtrate is taken to be concentrated to give clear cream, the first concentrate and ethanol water
The weight ratio of solution is 5:1；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, filters, obtains after taking supernatant
Second concentrate is placed under 300MHz microwave after being concentrated into clear cream by the second concentrate, and water is added, and stands divide after mixing evenly
Layer, filters after taking supernatant, obtains third concentrate, wherein clear cream and the weight ratio of dehydrated alcohol are 3:7 in step S1；
S3, third concentrate is placed at 0 DEG C after stratification, takes filtering plus water mixing, canned, sterilizing after supernatant,
Obtain Gotu Kola oral solution；
The Gotu Kola oral solution for being used to treat acute and chronic pharyngitis of the preparation method preparation of the Gotu Kola oral solution.
Embodiment 2:
The preparation method of Gotu Kola oral solution, comprising:
S1, Gotu Kola is placed in 60 DEG C of water and impregnates 40min taking-up, placed into ice water after impregnating 4h, add water to cook,
Mixed liquor is obtained, is filtered after mixed liquor is placed in 10 DEG C of standing 40min, is obtained the first concentrate, quality is added into the first concentrate
After the ethanol water that score is 80%, filtering for 24 hours is stood, heating after filtrate is taken to be concentrated to give clear cream, the first concentrate and ethyl alcohol
The weight ratio of aqueous solution is 5:1；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, filters, obtains after taking supernatant
Second concentrate is placed under 500MHz microwave after being concentrated into clear cream by the second concentrate, and water is added, and stands divide after mixing evenly
Layer, filters after taking supernatant, obtains third concentrate, wherein clear cream and the weight ratio of dehydrated alcohol are 3:7 in step S1；
S3, third concentrate is placed at 4 DEG C after stratification, takes filtering plus water mixing, canned, sterilizing after supernatant,
Obtain Gotu Kola oral solution；
The Gotu Kola oral solution for being used to treat acute and chronic pharyngitis of the preparation method preparation of the Gotu Kola oral solution.
Embodiment 3:
The preparation method of Gotu Kola oral solution, comprising:
S1, Gotu Kola is placed in 55 DEG C of water and impregnates 35min taking-up, placed into ice water after impregnating 3h, add water to cook,
Mixed liquor is obtained, is filtered after mixed liquor is placed in 80 DEG C of standing 30min, is obtained the first concentrate, quality is added into the first concentrate
After the ethanol water that score is 80%, filtering for 24 hours is stood, heating after filtrate is taken to be concentrated to give clear cream, the first concentrate and ethyl alcohol
The weight ratio of aqueous solution is 5:1；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, filters, obtains after taking supernatant
Second concentrate is placed under 400MHz microwave after being concentrated into clear cream by the second concentrate, and water is added, and stands divide after mixing evenly
Layer, filters after taking supernatant, obtains third concentrate, wherein clear cream and the weight ratio of dehydrated alcohol are 3:7 in step S1；
S3, third concentrate is placed at 2 DEG C after stratification, takes filtering plus water mixing, canned, sterilizing after supernatant,
Obtain Gotu Kola oral solution；
The Gotu Kola oral solution for being used to treat acute and chronic pharyngitis of the preparation method preparation of the Gotu Kola oral solution.
Embodiment 4:
The preparation method of Gotu Kola oral solution, comprising:
S1, Gotu Kola is placed in 55 DEG C of water and impregnates 35min taking-up, placed into ice water after impregnating 3h, add water to cook,
Mixed liquor is obtained, is filtered after mixed liquor is placed in 8 DEG C of standing 30min, obtains the first concentrate, quality point is added into the first concentrate
Number stands filtering for 24 hours, heating after filtrate is taken to be concentrated to give clear cream, the first concentrate to heat concentration after 80% ethanol water
Weight ratio with ethanol water is 5:1；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, filters, obtains after taking supernatant
Second concentrate is placed under 400MHz microwave after being concentrated into clear cream by the second concentrate, and water is added, and stands divide after mixing evenly
Layer, filters after taking supernatant, obtains third concentrate, wherein clear cream and the weight ratio of dehydrated alcohol are 3:7 in step S1；
S3, it sucrose is added into third concentrate is placed on stratification at 2 DEG C, filtering plus water is taken after supernatant to mix,
Canned, sterilizing, obtains Gotu Kola oral solution, and the weight ratio of third concentrate and sucrose is 10:3；
The Gotu Kola oral solution for being used to treat acute and chronic pharyngitis of the preparation method preparation of the Gotu Kola oral solution.
Embodiment 5:
The preparation method of Gotu Kola oral solution, comprising:
S1, Gotu Kola is placed in 55 DEG C of water and impregnates 35min taking-up, placed into ice water after impregnating 3h, add water to cook,
Mixed liquor is obtained, is filtered after mixed liquor is placed in 8 DEG C of standing 30min, obtains the first concentrate, quality point is added into the first concentrate
After number is 80% ethanol water, filtering for 24 hours is stood, taking after filtrate that heating is concentrated into relative density is 1.18, is obtained clearly
The weight ratio of cream, the first concentrate and ethanol water is 5:1；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, filters, obtains after taking supernatant
Second concentrate is placed under 400MHz microwave after being concentrated into the clear cream that relative density is 1.18 by the second concentrate, and water is added,
Stratification after mixing evenly filters after taking supernatant, obtains third concentrate, wherein clear cream and dehydrated alcohol in step S1
Weight ratio is 3:7；
S3, it sucrose is added into third concentrate is placed on stratification at 2 DEG C, filtering plus water is taken after supernatant to mix,
Canned, sterilizing, obtains Gotu Kola oral solution, and the weight ratio of third concentrate and sucrose is 10:3；
The Gotu Kola oral solution for being used to treat acute and chronic pharyngitis of the preparation method preparation of the Gotu Kola oral solution.
Embodiment 6:
The preparation method of Gotu Kola oral solution, comprising:
S1, Gotu Kola is placed in 55 DEG C of water and impregnates 35min taking-up, placed into ice water after impregnating 3h, add water to cook,
Mixed liquor is obtained, is filtered after mixed liquor is placed in 8 DEG C of standing 30min, obtains the first concentrate, quality point is added into the first concentrate
After number is 80% ethanol water, filtering for 24 hours is stood, taking after filtrate that heating is concentrated into relative density is 1.18, is obtained clearly
The weight ratio of cream, the first concentrate and ethanol water is 5:1；
Wherein, point 2 progress are decocted in S1, are decocted 60min every time, are collected the first decoction liquor after the 1st decoction, add
It is carried out the 2nd time after decocting with the water of the weight such as the first decoction liquor, collects the second decoction liquor, merged the first decoction liquor and second and decoct
Liquid obtains mixed liquor；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, filters, obtains after taking supernatant
Second concentrate is placed under 400MHz microwave after being concentrated into the clear cream that relative density is 1.18 by the second concentrate, and water is added,
Stratification after mixing evenly filters after taking supernatant, obtains third concentrate, wherein clear cream and dehydrated alcohol in step S1
Weight ratio is 3:7；
S3, it sucrose is added into third concentrate is placed on stratification at 2 DEG C, filtering plus water is taken after supernatant to mix,
Canned, sterilizing, obtains Gotu Kola oral solution, and the weight ratio of third concentrate and sucrose is 10:3；
The Gotu Kola oral solution for being used to treat acute and chronic pharyngitis of the preparation method preparation of the Gotu Kola oral solution.
Embodiment 7:
The preparation method of Gotu Kola oral solution, comprising:
S1, Gotu Kola is placed in 55 DEG C of water and impregnates 35min taking-up, placed into ice water after impregnating 3h, add water to cook,
Mixed liquor is obtained, is filtered after mixed liquor is placed in 8 DEG C of standing 30min, obtains the first concentrate, quality point is added into the first concentrate
After number is 80% ethanol water, filtering for 24 hours is stood, taking after filtrate that heating is concentrated into relative density is 1.18, is obtained clearly
The weight ratio of cream, the first concentrate and ethanol water is 5:1；
Wherein, point 2 progress are decocted in S1, are decocted 60min every time, are collected the first decoction liquor after the 1st decoction, add
It is carried out the 2nd time after decocting with the water of the weight such as the first decoction liquor, collects the second decoction liquor, merged the first decoction liquor and second and decoct
Liquid obtains mixed liquor；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, filters, obtains after taking supernatant
Second concentrate is placed under 400MHz microwave after being concentrated into the clear cream that relative density is 1.18 by the second concentrate, and water is added,
Stratification after mixing evenly filters after taking supernatant, obtains third concentrate, wherein clear cream and dehydrated alcohol in step S1
Weight ratio is 3:7；
S3, it sucrose is added into third concentrate is placed on stratification at 2 DEG C, filtering plus water is taken after supernatant to mix,
Canned, sterilizing, obtains Gotu Kola oral solution, and the weight ratio of third concentrate and sucrose is 10:3；
The Gotu Kola oral solution for being used to treat acute and chronic pharyngitis of the preparation method preparation of the Gotu Kola oral solution.
Embodiment 8:
The preparation method of Gotu Kola oral solution, comprising:
S1, Gotu Kola is placed in 55 DEG C of water and impregnates 35min taking-up, placed into ice water after impregnating 3h, be immersed in water
In be placed in ultrasonication 45min at 45 DEG C with 35kHz, then after being placed at 62 DEG C and drying 30min, crush, cross 110 meshes
After add water to cook, obtain mixed liquor, filtered after mixed liquor is placed in 8 DEG C of standing 30min, the first concentrate is obtained, to the first concentrate
After the middle ethanol water that mass fraction is added and is 80%, filtering for 24 hours is stood, takes after filtrate heating to be concentrated into relative density equal
It is 1.18, obtains clear cream, the weight ratio of the first concentrate and ethanol water is 5:1；
Wherein, point 2 progress are decocted in S1, are decocted 60min every time, are collected the first decoction liquor after the 1st decoction, add
It is carried out the 2nd time after decocting with the water of the weight such as the first decoction liquor, collects the second decoction liquor, merged the first decoction liquor and second and decoct
Liquid obtains mixed liquor；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, filters, obtains after taking supernatant
Second concentrate is placed under 400MHz microwave after being concentrated into the clear cream that relative density is 1.18 by the second concentrate, and water is added,
Stratification after mixing evenly filters after taking supernatant, obtains third concentrate, wherein clear cream and dehydrated alcohol in step S1
Weight ratio is 3:7；
S3, it sucrose is added into third concentrate is placed on stratification at 2 DEG C, filtering plus water is taken after supernatant to mix,
Canned, sterilizing, obtains Gotu Kola oral solution, and the weight ratio of third concentrate and sucrose is 10:3；
The Gotu Kola oral solution for being used to treat acute and chronic pharyngitis of the preparation method preparation of the Gotu Kola oral solution.
Embodiment 9:
The preparation method of Gotu Kola oral solution, comprising:
S1, Gotu Kola is placed in 55 DEG C of water and impregnates 35min taking-up, placed into ice water after impregnating 3h, be immersed in water
In be placed in ultrasonication 45min at 45 DEG C with 35kHz, then after being placed at 62 DEG C and drying 30min, crush, cross 110 meshes
Afterwards plus water and with Gotu Kola weight ratio be 7:1 antioxidant decoct again, obtain mixed liquor, mixed liquor be placed in 8 DEG C of standing 30min
After filter, obtain the first concentrate, into the first concentrate be added mass fraction be 80% ethanol water after, stand for 24 hours, mistake
Filter, taking after filtrate that heating is concentrated into relative density is 1.18, obtains clear cream, and the weight ratio of the first concentrate and ethanol water is
5:1；
Wherein, point 2 progress are decocted in S1, are decocted 60min every time, are collected the first decoction liquor after the 1st decoction, add
It is carried out the 2nd time after decocting with the water of the weight such as the first decoction liquor, collects the second decoction liquor, merged the first decoction liquor and second and decoct
Liquid obtains mixed liquor；
Antioxidant the preparation method is as follows:
Q1, the race for taking 125 parts by weight, the Guava Leaf of 150 parts by weight, the orange peel of 300 parts by weight, 150 parts by weight
Wheat embryo be respectively washed clean, drying after, be uniformly mixed, obtain mixture；
Q2, mixture is placed in 170 DEG C of temperature and pressure 1.07Mpa steam extraction 3h, collects cooling after vapor,
Distillate, be added into distillate 1500 parts by weight mass fraction be 70% ethanol water, be placed at 45 DEG C with
After the revolving speed processing 30min of 250r/min, stratification takes upper liquid, obtains extract liquor；
Q3, extract liquor is placed in concentration at 55 DEG C, is dry, obtaining solid powder, as antioxidant；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, filters, obtains after taking supernatant
Second concentrate is placed under 400MHz microwave after being concentrated into the clear cream that relative density is 1.18 by the second concentrate, and water is added,
Stratification after mixing evenly filters after taking supernatant, obtains third concentrate, wherein clear cream and dehydrated alcohol in step S1
Weight ratio is 3:7；
S3, it sucrose is added into third concentrate is placed on stratification at 2 DEG C, filtering plus water is taken after supernatant to mix,
Canned, sterilizing, obtains Gotu Kola oral solution, and the weight ratio of third concentrate and sucrose is 10:3；
The Gotu Kola oral solution for being used to treat acute and chronic pharyngitis of the preparation method preparation of the Gotu Kola oral solution.
Embodiment 10:
The preparation method of Gotu Kola oral solution, comprising:
S1, Gotu Kola is placed in 55 DEG C of water and impregnates 35min taking-up, placed into ice water after impregnating 3h, be immersed in water
In be placed in ultrasonication 45min at 45 DEG C with 35kHz, then after being placed at 62 DEG C and drying 30min, crush, cross 110 meshes
Afterwards plus water and with Gotu Kola weight ratio be 7:1 antioxidant decoct again, obtain mixed liquor, mixed liquor be placed in 8 DEG C of standing 30min
After filter, obtain the first concentrate, into the first concentrate be added mass fraction be 80% ethanol water after, stand for 24 hours, mistake
Filter, taking after filtrate that heating is concentrated into relative density is 1.18, obtains clear cream, and the weight ratio of the first concentrate and ethanol water is
5:1；
Wherein, point 2 progress are decocted in S1, are decocted 60min every time, are collected the first decoction liquor after the 1st decoction, add
It is carried out the 2nd time after decocting with the water of the weight such as the first decoction liquor, collects the second decoction liquor, merged the first decoction liquor and second and decoct
Liquid obtains mixed liquor；
Antioxidant the preparation method is as follows:
Q1, the race for taking 125 parts by weight, the Guava Leaf of 150 parts by weight, the orange peel of 300 parts by weight, 150 parts by weight
Wheat embryo be respectively washed clean, drying after, be uniformly mixed, obtain mixture；
Q2, mixture is placed in 170 DEG C of temperature and pressure 1.07Mpa steam extraction 3h, collects cooling after vapor,
Distillate, be added into distillate 1500 parts by weight mass fraction be 70% ethanol water, be placed at 45 DEG C with
After the revolving speed processing 30min of 250r/min, stratification takes upper liquid, obtains extract liquor；
Q3, extract liquor is placed in concentration at 55 DEG C, is dry, obtaining solid powder, as antioxidant；
S2, cane leaves, wild chrysanthemum, the leaf of bamboo, dehydrated alcohol are added in clear cream into step S1, wherein clear cream and cane leaves, mother chrysanthemum
Flower, the leaf of bamboo weight ratio be 9:2:1:2, stratification, is filtered after taking supernatant after mixing evenly, the second concentrate is obtained, by the
Two concentrates are placed under 400MHz microwave be concentrated into the clear cream that relative density is 1.18 after, be added water, stand after mixing evenly
Layering, filters after taking supernatant, obtains third concentrate, wherein clear cream and the weight ratio of dehydrated alcohol are 3:7 in step S1；
S3, it sucrose is added into third concentrate is placed on stratification at 2 DEG C, filtering plus water is taken after supernatant to mix,
Canned, sterilizing, obtains Gotu Kola oral solution, and the weight ratio of third concentrate and sucrose is 10:3；
The Gotu Kola oral solution for being used to treat acute and chronic pharyngitis of the preparation method preparation of the Gotu Kola oral solution.
Comparative example 1:
On the basis of embodiment 10, Gotu Kola is immersed in the ultrasonic wave being placed at 45 DEG C with 35kHz in water in S1
Processing 45min, then be placed at 62 DEG C after drying 30min, it crushes, adds water and with Gotu Kola weight ratio after crossing 110 meshes for 7:1's
Antioxidant decocts again, obtains mixed liquor, filters after mixed liquor is placed in 8 DEG C of standing 30min, obtains the first concentrate, dense to first
After the ethanol water that mass fraction is 80% is added in contracting liquid, filtering for 24 hours is stood, takes after filtrate heating to be concentrated into relatively close
Degree is 1.18, obtains clear cream, and the weight ratio of the first concentrate and ethanol water is 5:1.Other operations are same as in Example 10.
Comparative example 2:
On the basis of embodiment 10, Gotu Kola is placed in 55 DEG C of water in S1 and impregnates 35min taking-up, places into ice water
After middle immersion 3h, adds water and decocted again with Gotu Kola weight ratio for the antioxidant of 7:1, obtain mixed liquor, mixed liquor is placed in 8 DEG C
It is filtered after standing 30min, obtains the first concentrate, after the ethanol water that mass fraction is 80% is added into the first concentrate,
Filtering for 24 hours is stood, taking after filtrate that heating is concentrated into relative density is 1.18, obtains clear cream, the first concentrate and ethanol water
Weight ratio be 5:1.Other operations are same as in Example 10.
Comparative example 3:
On the basis of embodiment 10, Gotu Kola is placed in 55 DEG C of water in S1 and impregnates 35min taking-up, places into ice water
After middle immersion 3h, it is immersed in the ultrasonication 45min being placed at 45 DEG C with 35kHz in water, then be placed at 62 DEG C and dry
It after 30min, crushes, add water after crossing 110 meshes and is decocted again with Gotu Kola weight ratio for the antioxidant of 7:1, obtain mixed liquor, it will
Mixed liquor filters after being placed in 8 DEG C of standing 30min, obtains the first concentrate, and the first concentrate is stood filtering for 24 hours, is added after taking filtrate
Thermal concentration to relative density is 1.18, obtains clear cream, and the weight ratio of the first concentrate and ethanol water is 5:1.Other operations
It is same as in Example 10.
Comparative example 4:
On the basis of embodiment 10, Gotu Kola is placed in 55 DEG C of water in S1 and impregnates 35min taking-up, places into ice water
After middle immersion 3h, it is immersed in the ultrasonication 45min being placed at 45 DEG C with 35kHz in water, then be placed at 62 DEG C and dry
It after 30min, crushes, is decocted again after crossing 110 meshes, obtain mixed liquor, filtered after mixed liquor is placed in 8 DEG C of standing 30min, obtain first
Concentrate after the ethanol water that mass fraction is 80% is added into the first concentrate, stands filtering for 24 hours, adds after taking filtrate
Thermal concentration to relative density is 1.18, obtains clear cream, and the weight ratio of the first concentrate and ethanol water is 5:1.Other operations
It is same as in Example 10.
Comparative example 5:
On the basis of embodiment 10, the ethyl alcohol that the mass fraction of 1500 parts by weight is 70% is added in Q2 into mixture
Aqueous solution is placed at 45 DEG C after handling 30min with the revolving speed of 250r/min, and stratification takes upper liquid, obtains extract liquor.It is other
It operates same as in Example 10.
Interpretation of result
1, comparative example 1-5 and the resulting Gotu Kola oral solution of embodiment 10 are subjected to quality and yield compares, wherein Thunder God
Yield=m '/m of root oral solution, m ' be Gotu Kola oral solution drying quality, m be Gotu Kola, sucrose, antioxidant, cane leaves,
Wild chrysanthemum, the leaf of bamboo weight and, the results are shown in Table 1.
The sense organ and yield of 1 Gotu Kola oral solution of table
As can be known from Table 1, good organoleptic quality is all had compared to comparative example 4-5, comparative example 1-3 and embodiment 10,
Antioxidant is not added in comparative example 4, so that Gotu Kola moieties in decoction process are oxidized, effective component is broken
Oral solution yellowish that is bad, therefore generating, low yield 76.4；Antioxidant does not use water during the preparation process in comparative example 5
Steam extraction, extraction efficiency is low, and obtained antioxidant effective component is not high, to affect the function and effect of antioxidant；
Non- Gotu Kola does not carry out dip operation before decoction in comparative example 1, so that Thunder God root cells is to be completely severed, intracellular content
Object is not completely dissolved out, reduces extraction efficiency；Ultrasonication is not used before decoction in comparative example 2, thus Thunder God
The rupture of root cells is not thorough, and there are also the intracellular contents in part not to be completely dissolved out, reduces extraction efficiency；Comparative example 3
In be not added mass fraction be 80% ethanol water, the influence to product is little, mainly using ethanol water filter
Removal of impurities and raising heating concentration speed, shorten working hour.
2, comparative example 1-4 and the resulting Gotu Kola oral solution of embodiment 8 are placed at 38 ± 1 DEG C of temperature and humidity 75% again
After placing 90 days, detection bacterium situation the results are shown in Table 2.
Bacteria Detection situation after 2 Gotu Kola oral solution of table is placed 90 days
As shown in Table 2, the Bacteria Detection result of Gotu Kola oral solution obtained by comparative example 1-5 and embodiment 10 reaches
Mark, illustrates that Gotu Kola oral solution obtained by comparative example 1-5 and embodiment 10 all has certain shelf-life.
3, animal toxicology is tested: after Gotu Kola oral solution obtained by embodiment 10 is concentrated 10 times, selecting 20-22 grams
SPF Kunming mice 20, half male and half female is tested, with the oral primary filling of the dosage (concentrate) of 22.4g/kgBW
Stomach, stomach-filling amount are 0.2ml/10kgBW, are observed continuously after administration 15 days.Poisoning manifestations and death condition are recorded, the results are shown in Table
3.
Acute toxicity of the 3 Gotu Kola oral solution (concentrate) of table to large and small mouse
As shown in Table 3, it with the rats and mice of the dosage of 22.4g/kgBW (concentrate) two kinds of genders of stomach-filling, observes 15 days,
Apparent poisoning manifestations are had no during test, also without death condition.Oral acute poison of the tested material to the large and small mouse of two kinds of genders
Property test (MTD) be all larger than 22.4g/kgBW, analyzed according to acute toxicity, Gotu Kola oral solution belongs to non-poisonous material.
4, pharmacological is tested: patient A 47 years old, suffers from sphagitis 4 years, injection of vocal cord, hoarseness, influences communication of speaking.
The resulting Gotu Kola oral solution of embodiment 10 is taken after 60 days, injection of vocal cord disappears, and movement is good, and hoarseness is clearly better,
Continue to take 90 courses for the treatment of, all diseases disappear, recovery from illness.
Patient B, 28 years old, abundant expectoration, larynx itched and are easy dry cough, and tongue fur whitens, speaks and slightly pant, and took 10 gained of embodiment
Gotu Kola oral solution 30 days after, dry cough symptom disappear, breath of speaking is steadily strong, recovery from illness.
Patient C, 33 years old, hoarseness 3 months, larynx was itched and dry cough is rubescent, swells, and existing with throat partial gall
As taking the resulting Gotu Kola oral solution of embodiment 10 after 30 days, larynx is itched and dry cough is rubescent, symptom of swelling is eased, sound
It is hoarse to be clearly better, continue to take the resulting Gotu Kola oral solution of embodiment 10 after 30 days, all diseases disappear, recovery from illness.
Patient D, 31 years old, hoarseness 1 week, larynx itched and is easy dry cough, took the resulting Gotu Kola oral solution of embodiment 10
After 10 days, dry cough symptom disappears, and breath of speaking is steadily strong, recovery from illness.
In conclusion illustrating that the resulting Gotu Kola oral solution of embodiment 10 is nontoxic and has certain treatment acute and chronic throat
Scorching effect.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details.
Claims (8)
1. the preparation method of Gotu Kola oral solution characterized by comprising
S1, Gotu Kola is placed in 50-60 DEG C of water and impregnates 30-40min taking-up, placed into ice water after impregnating 2-4h, add water
It decocts, obtains mixed liquor, filtered after mixed liquor is placed in 5-10 DEG C of standing 20-40min, obtain the first concentrate, to the first concentrate
After the middle ethanol water that mass fraction is added and is 80%, filtering for 24 hours is stood, takes heating after filtrate to be concentrated to give clear cream, first is dense
The weight ratio of contracting liquid and ethanol water is 5:1；
S2, dehydrated alcohol is added in clear cream into step S1, after mixing evenly stratification, is filtered after taking supernatant, obtains second
Second concentrate is placed under 300-500 MHz microwave after being concentrated into clear cream by concentrate, and water is added, and stands divide after mixing evenly
Layer, filters after taking supernatant, obtains third concentrate, wherein clear cream and the weight ratio of dehydrated alcohol are 3:7 in step S1；
S3, third concentrate is placed at 0-4 DEG C after stratification, takes filtering plus water mixing, canned, sterilizing after supernatant, obtains
Gotu Kola oral solution.
2. the preparation method of Gotu Kola oral solution as described in claim 1, which is characterized in that third concentrate exists in step S3
It is also added into sucrose before stratification, the weight ratio of third concentrate and sucrose is 10:3.
3. the preparation method of Gotu Kola oral solution as claimed in claim 2, which is characterized in that clear cream obtained in step S1 and
The relative density of clear cream is 1.15-1.20 in step S2.
4. the preparation method of Gotu Kola oral solution as claimed in claim 3, which is characterized in that decoct point 2 progress in S1, often
Secondary decoction 40-80min collects the first decoction liquor after the 1st decoction, adds and the water of the weight such as the first decoction liquor carries out the 2nd
After secondary decoction, the second decoction liquor is collected, merges the first decoction liquor and the second decoction liquor, obtains mixed liquor.
5. the preparation method of Gotu Kola oral solution as claimed in claim 4, which is characterized in that Gotu Kola is decocting in step S1
Before, it also needs to be immersed in the ultrasonication 30-60min being placed in water at 40-50 DEG C with 20-50kHz after impregnating, then sets
It after drying 20-40min at 55-70 DEG C, crushes, crosses 100-120 mesh.
6. the preparation method of Gotu Kola oral solution as claimed in claim 5, which is characterized in that Gotu Kola is decocting in step S1
Before, impregnate after also need be added with Gotu Kola weight ratio be 7:1 antioxidant, antioxidant the preparation method is as follows:
Q1, the race for taking 100-150 parts by weight, the Guava Leaf of 100-200 parts by weight, 200-400 parts by weight orange peel,
After the wheat embryo of 100-200 parts by weight is respectively washed clean, drying, it is uniformly mixed, obtains mixture；
Q2, mixture is placed in 140-200 DEG C of temperature and pressure 1.06-1.08 Mpa steam extraction 2-4h, collects water and steams
It is cooling after gas, distillate is obtained, the ethanol water that the mass fraction of 1200-1800 parts by weight is 70% is added into distillate,
It is placed at 40-50 DEG C after handling 20-40min with the revolving speed of 200-300r/min, stratification takes upper liquid, obtains extract liquor；
Q3, extract liquor is placed in concentration at 50-60 DEG C, is dry, obtaining solid powder, as antioxidant.
7. the preparation method of Gotu Kola oral solution as claimed in claim 6, which is characterized in that nothing is being added in clear cream in step S2
Before water-ethanol, also need that cane leaves, wild chrysanthemum, the leaf of bamboo are added, wherein clear cream and cane leaves, wild chrysanthemum, the leaf of bamboo weight ratio be 9:2:
1:2。
8. as prepared by the preparation method of Gotu Kola oral solution of any of claims 1-7 swallows for treating acute and chronic
The Gotu Kola oral solution of laryngitis.
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