CN108159363A - Liver cancer healing liquid and preparation method thereof - Google Patents
Liver cancer healing liquid and preparation method thereof Download PDFInfo
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- CN108159363A CN108159363A CN201810250969.2A CN201810250969A CN108159363A CN 108159363 A CN108159363 A CN 108159363A CN 201810250969 A CN201810250969 A CN 201810250969A CN 108159363 A CN108159363 A CN 108159363A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of liver cancer healing liquid and preparation method thereof, the liver cancer healing liquid includes following raw materials：The radicants extracting solutions such as Lowiaceae axis, leaf, bar, flower extract liquor, turmeric.The liver cancer healing liquid of the present invention, the extraction of 100% pure plant have liver cancer cells apparent inhibition and dissipation effect, have exact therapeutic effect to liver cancer, and it has no toxic and side effect to human body, and good effect, short treating period, highly effective and safe, instructions of taking is easy, and herb resource enriches, and cost is controllable.
Description
Technical field
The present invention relates to a kind of cancer rehabilitation liquid more particularly to a kind of liver cancer healing liquid and preparation method thereof.
Background technology
Tumor disease is quickly grown, it is contemplated that will be up to 20,000,000 to the new hair tumor cases in the year two thousand twenty whole world, Cancer in China is fallen ill
Rate also in situation is persistently risen, such as takes no action to for many years, 4,000,000 people will be risen to the year two thousand twenty incidence.
Cancer rehabilitation proposed in the works in National Cancer in 1971, and injected capital into and carry out correlative study.1972,
US National cancer research institute has held " cancer rehabilitation planning conference ", and cancer rehabilitation is clearly divided into：Social mentality's support,
Physical efficiency optimization, job supervision and social function optimize four aspects.It is mentioned in american cancer rehabilitation guides in 2013, for youth
And the rehabilitation of Young Adults tumor patient, including：Correctly in face of disease, the various treatment means of cancer are understood, selection is suitable
The treatment of oneself is closed, manages most common treatment adverse reaction, enriches the personal lifestyle outside treatment, health planning is promoted, appeases
Treatment and deathbed care etc..American Cancer Society《Cancer survivor nutrition and movement guide》It emphasizes, in the cancer active treatment phase
Between, the overall goal that patient's nutrition is looked after should be：Subalimentation, weight of keeping fit are prevented or solve, fat-body is removed in maintenance
Weight reduces malnutritive related reactions, improves the quality of living.Research confirms, nutrition consultation is carried out during treatment and is done
In advance, curative effect, such as reduction or the relevant symptom of remissive treatment, quality of making the life better and nutrition intake are helped to improve.Various countries pair
All there is common recognition in the status of cancer rehabilitation and meaning.
A large amount of research confirms that supplement alternative medicine means are such as：Acupuncture, massage, Yoga, music and body and mind therapy can pacify
Body and mood related symptoms are effectively improved entirely, there is good interests Hazard ratio, is very suitable for the demand of tumor patient.Supplement
The means of alternative medicine body and mind intervention include：Acupuncture, Alexandria body-building method, respiration exercise, pilates, meditation, hypnosis, guiding
The imagination, carrier psychophysics are integrated, are actively loosened, Tai Ji, anima, Yoga, cure tactile, spinal manipulation, the qigong, massage
Peter Krass limbs relaxed method and reflexotherapy are stepped in therapy, craniosacral therapy, Fil.The natural prodcuts classification of supplement alternative medicine includes
Dietary supplement, Kang Baolai plant products, conventional medicament formula, folk medicine, homeotherapy, probiotics and the plant based on food
Object chemical substance.Tai Ji, acupuncture, traditional Chinese medicine and autonomic drug development and application it is more and more, supplementing the development of alternative medicine will be
The clinical practice of traditional Chinese medicine provides good medical evidence guidance.
Tumor patient has rehabilitation great demand, with greater need for the guidance of profession.Chinese medicine rehabilitation has comprehensive, individuation
And the characteristics of life-stylize, Chinese medicine rehabilitation means can improve patient's mental and physical, improve tolerance to treatment and life quality.The traditional Chinese medical science
The scientific research of comprehensive cancer rehabilitation and practice have obtained preliminary progress, but combined rehabilitation scheme is it is still necessary to further investigate, scientific evaluation.
Liver cancer is one of common malignant tumour in China, liver cancer early stage non-evident sympton, therefore easy delay diagnosis, symptom occurs
When it is more belong to late periods, common clinical manifestation is hepatalgia, liver progressive enlargement, low-heat, jaundice, abdominal distension, anorexia,
Nausea and vomiting, become thin weak, oedema and progressive anaemia etc., because it is found that rear progress is rapid, the death rate is high, therefore seriously endangers
The life and health of people.The pathogenic factor of liver cancer：From the viewpoint of doctor trained in Western medicine, pathogenic factor is not yet clear and definite.
It is now recognized that the morbidity of following factor and liver cancer is closely related：1st, chronic hepatic diseases virus hepatitis and liver cancer
It falls ill related, it is B-mode in hepatitis, it is the main Types of induced hepatocellular carcinoma.The morbidity of cirrhosis and liver cancer is also closely related, shows
Hepatitis-cirrhosis-liver cancer has close contact in path, and mainly related with hepatitis B；2nd, chemical pathogenic substance is such as
The chemical substances such as aflatoxins, nitrous acid amine, carbon tetrachloride, azobenzene can induced hepatocellular carcinoma；3rd, other malnutritive, something lost
Biography, certain liver parasites also can induced hepatocellular carcinomas；Therefrom medicine viewpoint thinks that pathogenesis of cancer reason is complex, and liver cancer is liver
Blood stasis, the stagnation of the circulation of vital energy, phlegm coagulate, cult poison knot gathers.
Invention content
In order to overcome problems of the prior art and difficulty, the present invention provides a kind of liver cancer healing liquid and its preparation side
Method.
The technical scheme is that：
The liver cancer healing liquid of the present invention, including following raw materials：Lowiaceae plant extraction liquid, turmeric extracting solution.
The liver cancer healing liquid, including following weight parts raw material：95-105 parts of Lowiaceae plant extraction liquid, turmeric extracting solution
15-25 parts.
The liver cancer healing liquid, further includes following weight parts raw material：5-15 parts of rhizoma imperatae extract liquor.
The liver cancer healing liquid, further includes following weight parts raw material：10-20 parts of chrysanthemum extract liquor.
The preparation method of the Lowiaceae plant extraction liquid, includes the following steps：
(1) 30-50g bananas bark is added in 60-200g boiling water and scalded 3-8 minutes, surface moisture is drained, then by 20-
40g bananas bark, 25-50g Banana trees stem, 10-20g bananas leaf are 6-12 hours dry at 40-60 DEG C, by banana bark, perfume (or spice)
Any of several broadleaf plants tree stem, banana leaf smash it through 20-50 mesh sieve respectively, are uniformly mixed that obtain mixture spare；
(2) 12-36g mixtures are taken, are added to the sodium chloride that 40-80g mass fractions are 3-10%, temperature is 35-55 DEG C
In aqueous solution, ultrasonic extraction 35-65 minutes under the conditions of power is 200-800W, frequency is 40-50KHz, with 4000-10000
Rev/min rotating speed centrifuge 20-60 minute, take the supernatant liquid after centrifugation, cross 100-500 mesh sieve, reservation filtrate is to get Lowiaceae
Plant extraction liquid.
Preferably, the preparation method of the Lowiaceae plant extraction liquid, includes the following steps：
(1) 30-50g bananas bark is added in 60-200g boiling water and scalded 3-8 minutes, surface moisture is drained, then by 20-
40g bananas bark, 25-50g Banana trees stem, 10-20g bananas leaf are 6-12 hours dry at 40-60 DEG C, by banana bark, perfume (or spice)
Any of several broadleaf plants tree stem, banana leaf smash it through 20-50 mesh sieve respectively, are uniformly mixed and obtain mixture, by mixture at -45~-40 DEG C
Freezing 30-90 minutes, then with power is 300-500W, microwave heating that frequency is 2450-3000MHz 5-25 minutes, -35
~-30 DEG C freeze 20-60 minutes, then with 5-20 points of the microwave heating that power is 300-500W, frequency is 2450-3000MHz
Clock is freezed 10-40 minutes at -25~-20 DEG C, is then added with the microwave that power is 300-500W, frequency is 2450-3000MHz
It is 3-15 minutes hot, it is then placed 30-90 minutes in 30-60 DEG C of insulating box, the mixture pre-processed；
(2) 12-36g mixtures are taken, are added to the sodium chloride that 40-80g mass fractions are 3-10%, temperature is 35-55 DEG C
In aqueous solution, ultrasonic extraction 35-65 minutes under the conditions of power is 200-800W, frequency is 40-50KHz, with 4000-10000
Rev/min rotating speed centrifuge 20-60 minute, take the supernatant liquid after centrifugation, cross 100-500 mesh sieve, reservation filtrate is to get Lowiaceae
Plant extraction liquid.
The preparation method of the turmeric extracting solution, includes the following steps：Turmeric is smashed it through into 20-50 mesh sieve, is added to
Temperature is in 35-55 DEG C of water, and the mass ratio of the turmeric and water is 1：(5-15), ultrasonic extraction 50-70 minutes, the ultrasound
The ultrasonic power of extraction is 150-350W, supersonic frequency 25-45kHz, and 20-60 is centrifuged with 4000-8000 revs/min of rotating speed
Minute, take the supernatant liquid after centrifugation, cross 100-500 mesh sieve, retain filtrate to get.
Preferably, the preparation method of the turmeric extracting solution, includes the following steps：Turmeric is smashed it through into 20-50 mesh
Sieve is added in the water that temperature is 35-55 DEG C, adds and help extractant, and the mass ratio of the turmeric and water is 1：(5-15), institute
State help extractant and turmeric mass ratio be 1：(5-15), ultrasonic extraction 50-70 minutes, the ultrasonic power of the ultrasonic extraction are
150-350W, supersonic frequency 25-45kHz are centrifuged 20-60 minutes with 4000-8000 revs/min of rotating speed, after taking centrifugation
Supernatant liquid crosses 100-500 mesh sieve, retain filtrate to get.
It is described to help extractant as citric acid monoglyceride and/or propylene glycol alginate.Preferably, it is described help extractant by
Citric acid monoglyceride, propylene glycol alginate are (1-3) in mass ratio：1 mixes.
The preparation method of the rhizoma imperatae extract liquor, includes the following steps：Rhizoma imperatae is smashed it through into 20-50 mesh sieve, is added
Enter into the sodium-chloride water solution that mass fraction is 2-7%, temperature is 40-50 DEG C, the rhizoma imperatae and sodium-chloride water solution
Mass ratio is 1：(5-15), ultrasonic extraction 50-70 minutes, the ultrasonic power of the ultrasonic extraction is 150-350W, supersonic frequency
It for 25-45kHz, is centrifuged 20-60 minutes with 4000-8000 revs/min of rotating speed, takes the supernatant liquid after centrifugation, cross 100-500
Mesh sieve, retain filtrate to get.
The preparation method of the chrysanthemum extract liquor, includes the following steps：Chrysanthemum is smashed it through into 20-50 mesh sieve, is added to
Temperature is in 60-80 DEG C of water, and the mass ratio of the chrysanthemum and water is 1：(5-15), ultrasonic extraction 50-70 minutes, the ultrasound
The ultrasonic power of extraction is 150-350W, supersonic frequency 25-45kHz, and 20-60 is centrifuged with 4000-8000 revs/min of rotating speed
Minute, take the supernatant liquid after centrifugation, cross 100-500 mesh sieve, retain filtrate to get.
The preparation method of above-mentioned liver cancer healing liquid mixes each raw material for 10-30 minutes by 200-500 revs/min of stirring of rotating speed
It closes uniformly to obtain the final product.
The liver cancer healing liquid dosage is daily 5-6 milliliters, can divide 2-8 times using absorption.
The liver cancer healing liquid of the present invention, the extraction of 100% pure plant have liver cancer cells apparent inhibition and dissipation to make
With there is exact therapeutic effect to liver cancer, and have no toxic and side effect to human body, and good effect, short treating period, highly effective and safe, take
With method simplicity, herb resource enriches, and cost is controllable.
Specific embodiment
The measure of DPPH free radical scavenging activities：Liver cancer healing liquid 1mL is drawn to be added in 5mL distilled water after mixing,
Obtain mixed liquor；2.2mL mixed liquors is taken to add in DPPH the free radical alcoholic solution 2mL, room temperature avoid light place 30min of 0.1mmol/L
Absorbance is measured at 517nm by reference of distilled water afterwards.Blank replaces sample with distilled water.It is calculated and removed according to following equation
Rate：Clearance rate (%)=(1-A1/A0) × 100%.In formula：A0Blank light absorption value at 517nm；A1Sample is inhaled at 517nm
Light value.
DPPH is a kind of free radical of stabilization (darkviolet is shown in methanol) in organic solvent, there is strong absorption at 517nm,
In the presence of having antioxidant, solution colour will shoal light absorption value reduction.Free radical is that human body produces in metabolic processes
Raw, it is in close relations with the generation of body aging and some diseases, such as cancer, atherosclerosis, senile dementia and part
Eye disease etc..The present invention, to the Scavenging activity of free radical, can reflect activity by comparing different embodiment liver cancer healing liquids
Difference.
Each raw material introduction in embodiment：
Banana bark, tree stem, leaf, Musaceae banana banana (Classification system：Musa nana Lour.) perfume (or spice)
Any of several broadleaf plants bark, tree stem, leaf, banana variety be Saigon any of several broadleaf plants, place of production Nanning.
Turmeric, Classification system：Curcuma longa L.It is provided by Xichou County Xiang Guang medicinal materials Co., Ltd, original producton location is cloud
South.
Citric acid monoglyceride, No. CAS：36291-32-4.It is provided by one hundred emerging bio tech ltd of Wuhan, rank is
Food-grade.
Propylene glycol alginate, No. CAS：9005-37-2.It is provided by Shandong Chuan Tian bio tech ltd, rank is food
Grade.
Rhizoma imperatae, Classification system：Imperata cylindrica.By Bozhou City, often rich medicine company sale Co., Ltd provides,
Original producton location is Anhui.
Chrysanthemum is the tribute chrysanthemum that Xichou County Xiang Guang medicinal materials Co., Ltd provides, and original producton location is Anhui.
Embodiment 1
Liver cancer healing liquid raw material (parts by weight)：100 parts of Lowiaceae plant extraction liquid, 20 parts of turmeric extracting solution.
The preparation method of the Lowiaceae plant extraction liquid, includes the following steps：
(1) 30g bananas bark is added in 100g boiling water and scalded 5 minutes, drain surface moisture；Then by 20g bananas bark,
25g Banana trees stem, 10g bananas leaf are 8 hours dry at 50 DEG C, after banana bark, Banana tree stem, banana leaf are crushed respectively
20 mesh sieve is crossed, is uniformly mixed that obtain mixture spare；
(2) 12g mixtures are taken, are added in the sodium-chloride water solution that 60g mass fractions are 3%, temperature is 35 DEG C, in work(
Ultrasonic extraction 35 minutes under the conditions of rate is 200W, frequency is 40KHz is centrifuged 30 minutes with 4000 revs/min of rotating speed, takes centrifugation
Supernatant liquid afterwards crosses 200 mesh sieve, retains filtrate to get Lowiaceae plant extraction liquid.
The preparation method of the turmeric extracting solution, includes the following steps：Turmeric is smashed it through into 20 mesh sieve, is added to temperature
In 45 DEG C of water, to add and helping extractant, the mass ratio of the turmeric and water is 1：10, the matter for helping extractant and turmeric
Amount is than being 1：8, ultrasonic extraction 60 minutes, the ultrasonic power of the ultrasonic extraction is 250W, supersonic frequency 40kHz, with 6000
Rev/min rotating speed centrifuge 30 minutes, take centrifugation after supernatant liquid, cross 300 mesh sieve, retain filtrate to get turmeric extracting solution.
It is described to help extractant as citric acid monoglyceride.
Each raw material is uniformly mixed i.e. by the preparation method of above-mentioned liver cancer healing liquid for 20 minutes by 300 revs/min of stirrings of rotating speed
.The measure of DPPH free radical scavenging activities is carried out to liver cancer healing liquid, DPPH clearance rates result is 91.9%.
Embodiment 2
Liver cancer healing liquid raw material (parts by weight)：100 parts of Lowiaceae plant extraction liquid, 20 parts of turmeric extracting solution.
The preparation method of the Lowiaceae plant extraction liquid, includes the following steps：
(1) 30g bananas bark is added in 100g boiling water and scalded 5 minutes, drain surface moisture；Then by 20g bananas bark,
25g Banana trees stem, 10g bananas leaf are 8 hours dry at 50 DEG C, after banana bark, Banana tree stem, banana leaf are crushed respectively
20 mesh sieve is crossed, is uniformly mixed and obtains mixture；Mixture is freezed 60 minutes at -40 DEG C, then be 500W with power, frequency is
The microwave heating of 2450MHz 10 minutes freezes 30 minutes at -30 DEG C, is then 500W with power, frequency is the micro- of 2450MHz
Wave heating 8 minutes, freezes 20 minutes at -25 DEG C, then with power is 500W, microwave heating that frequency is 2450MHz 5 minutes,
Then it is placed 40 minutes in 30 DEG C of insulating box, the mixture pre-processed；
(2) mixture that 12g is taken to pre-process, is added to the aqueous sodium chloride that 60g mass fractions are 3%, temperature is 35 DEG C
In liquid, the ultrasonic extraction 35 minutes under the conditions of power is 200W, frequency is 40KHz centrifuges 30 points with 4000 revs/min of rotating speed
Clock takes the supernatant liquid after centrifugation, crosses 200 mesh sieve, retains filtrate to get Lowiaceae plant extraction liquid.
The preparation method of the turmeric extracting solution is same as Example 1.
Each raw material is uniformly mixed i.e. by the preparation method of above-mentioned liver cancer healing liquid for 20 minutes by 300 revs/min of stirrings of rotating speed
.The measure of DPPH free radical scavenging activities is carried out to liver cancer healing liquid, DPPH clearance rates result is 93.2%.
Embodiment 3
Liver cancer healing liquid raw material (parts by weight)：100 parts of Lowiaceae plant extraction liquid, 20 parts of turmeric extracting solution, rhizoma imperatae extraction
10 parts of liquid.
The preparation method of the Lowiaceae plant extraction liquid is same as Example 2.
The preparation method of the turmeric extracting solution is same as Example 1.
The preparation method of the rhizoma imperatae extract liquor, includes the following steps：Rhizoma imperatae is smashed it through into 20 mesh sieve, is added to
In the sodium-chloride water solution that mass fraction is 5%, temperature is 45 DEG C, the mass ratio of the rhizoma imperatae and sodium-chloride water solution is 1：
6, ultrasonic extraction 60 minutes, the ultrasonic power of the ultrasonic extraction is 250W, supersonic frequency 40kHz, with 6000 revs/min
Rotating speed centrifuge 30 minutes, take centrifugation after supernatant liquid, cross 300 mesh sieve, retain filtrate to get.
Each raw material is uniformly mixed i.e. by the preparation method of above-mentioned liver cancer healing liquid for 20 minutes by 300 revs/min of stirrings of rotating speed
.
Embodiment 4
Liver cancer healing liquid raw material (parts by weight)：100 parts of Lowiaceae plant extraction liquid, 20 parts of turmeric extracting solution, rhizoma imperatae extraction
10 parts of liquid, 15 parts of chrysanthemum extract liquor.
The preparation method of the Lowiaceae plant extraction liquid is same as Example 2.
The preparation method of the turmeric extracting solution is same as Example 1.
The preparation method of the rhizoma imperatae extract liquor is same as Example 3.
The preparation method of the chrysanthemum extract liquor, includes the following steps：Chrysanthemum is smashed it through into 20 mesh sieve, is added to temperature
For in 70 DEG C of water, the mass ratio of the chrysanthemum and water is 1：10, ultrasonic extraction 60 minutes, the ultrasonic power of the ultrasonic extraction
It for 250W, supersonic frequency 40kHz, is centrifuged 30 minutes with 6000 revs/min of rotating speed, takes the supernatant liquid after centrifugation, cross 300
Mesh sieve, retain filtrate to get.
Each raw material is uniformly mixed i.e. by the preparation method of above-mentioned liver cancer healing liquid for 20 minutes by 300 revs/min of stirrings of rotating speed
.
Embodiment 5
Liver cancer healing liquid raw material (parts by weight)：100 parts of Lowiaceae plant extraction liquid, 20 parts of turmeric extracting solution.
The preparation method of the Lowiaceae plant extraction liquid, includes the following steps：
(1) will 30g bananas bark add in 100g boiling water in scald 5 minutes, drain surface moisture, then by 20g bananas bark,
25g Banana trees stem, 10g bananas leaf are 8 hours dry at 50 DEG C, after banana bark, Banana tree stem, banana leaf are crushed respectively
20 mesh sieve is crossed, is uniformly mixed and obtains mixture, mixture freezed 30 minutes at -45 DEG C, is then 500W with power, frequency
The microwave heating that rate is 2450MHz 8 minutes, freezes 20 minutes, then be 500W with power, frequency is 2450MHz's at -35 DEG C
Microwave heating 5 minutes is freezed 10 minutes at -20 DEG C, is then divided with the microwave heating 3 that power is 500W, frequency is 2450MHz
Then clock is placed 40 minutes, the mixture pre-processed in 30 DEG C of insulating box；
(2) mixture that 12g is taken to pre-process, is added to the aqueous sodium chloride that 60g mass fractions are 3%, temperature is 35 DEG C
In liquid, the ultrasonic extraction 35 minutes under the conditions of power is 200W, frequency is 40KHz centrifuges 30 points with 4000 revs/min of rotating speed
Clock takes the supernatant liquid after centrifugation, crosses 200 mesh sieve, retains filtrate to get Lowiaceae plant extraction liquid.
The preparation method of the turmeric extracting solution is same as Example 1.
Each raw material is uniformly mixed i.e. by the preparation method of above-mentioned liver cancer healing liquid for 20 minutes by 300 revs/min of stirrings of rotating speed
.The measure of DPPH free radical scavenging activities is carried out to liver cancer healing liquid, DPPH clearance rates result is 89.2%.
Embodiment 6
Liver cancer healing liquid raw material (parts by weight)：100 parts of Lowiaceae plant extraction liquid, 20 parts of turmeric extracting solution.
The preparation method of the Lowiaceae plant extraction liquid, includes the following steps：
(1) will 30g bananas bark add in 100g boiling water in scald 5 minutes, drain surface moisture, then by 20g bananas bark,
25g Banana trees stem, 10g bananas leaf are 8 hours dry at 50 DEG C, after banana bark, Banana tree stem, banana leaf are crushed respectively
20 mesh sieve is crossed, is uniformly mixed and obtains mixture, mixture freezed 90 minutes at -40 DEG C, is then 500W with power, frequency
The microwave heating that rate is 2450MHz 25 minutes, freezes 60 minutes at -30 DEG C, is then 500W with power, frequency 2450MHz
Microwave heating 15 minutes, freezed 40 minutes at -25 DEG C, then with the microwave heating 5 that power is 500W, frequency is 2450MHz
Minute, it is then placed 40 minutes in 30 DEG C of insulating box, the mixture pre-processed；
(2) mixture that 12g is taken to pre-process, is added to the aqueous sodium chloride that 60g mass fractions are 3%, temperature is 35 DEG C
In liquid, the ultrasonic extraction 35 minutes under the conditions of power is 200W, frequency is 40KHz centrifuges 30 points with 4000 revs/min of rotating speed
Clock takes the supernatant liquid after centrifugation, crosses 200 mesh sieve, retains filtrate to get Lowiaceae plant extraction liquid.
The preparation method of the turmeric extracting solution is same as Example 1.
Each raw material is uniformly mixed i.e. by the preparation method of above-mentioned liver cancer healing liquid for 20 minutes by 300 revs/min of stirrings of rotating speed
.The measure of DPPH free radical scavenging activities is carried out to liver cancer healing liquid, DPPH clearance rates result is 91.0%.
Embodiment 7
Liver cancer healing liquid raw material (parts by weight)：100 parts of Lowiaceae plant extraction liquid, 20 parts of turmeric extracting solution.
The preparation method of the Lowiaceae plant extraction liquid is same as Example 2.
The preparation method of the turmeric extracting solution, includes the following steps：Turmeric is smashed it through into 20 mesh sieve, is added to temperature
In 45 DEG C of water, to add and helping extractant, the mass ratio of the turmeric and water is 1：10, the matter for helping extractant and turmeric
Amount is than being 1：8, ultrasonic extraction 60 minutes, the ultrasonic power of the ultrasonic extraction is 250W, supersonic frequency 40kHz, with 6000
Rev/min rotating speed centrifuge 30 minutes, take centrifugation after supernatant liquid, cross 300 mesh sieve, retain filtrate to get turmeric extracting solution.
It is described to help extractant as propylene glycol alginate.
Each raw material is uniformly mixed i.e. by the preparation method of above-mentioned liver cancer healing liquid for 20 minutes by 300 revs/min of stirrings of rotating speed
.The measure of DPPH free radical scavenging activities is carried out to liver cancer healing liquid, DPPH clearance rates result is 92.5%.
Embodiment 8
Liver cancer healing liquid raw material (parts by weight)：100 parts of Lowiaceae plant extraction liquid, 20 parts of turmeric extracting solution.
The preparation method of the Lowiaceae plant extraction liquid is same as Example 2.
The preparation method of the turmeric extracting solution, includes the following steps：Turmeric is smashed it through into 20 mesh sieve, is added to temperature
In 45 DEG C of water, to add and helping extractant, the mass ratio of the turmeric and water is 1：10, the matter for helping extractant and turmeric
Amount is than being 1：8, ultrasonic extraction 60 minutes, the ultrasonic power of the ultrasonic extraction is 250W, supersonic frequency 40kHz, with 6000
Rev/min rotating speed centrifuge 30 minutes, take centrifugation after supernatant liquid, cross 300 mesh sieve, retain filtrate to get turmeric extracting solution.
It is described help extractant by citric acid monoglyceride, propylene glycol alginate in mass ratio be 3：1 mixes.
Each raw material is uniformly mixed i.e. by the preparation method of above-mentioned liver cancer healing liquid for 20 minutes by 300 revs/min of stirrings of rotating speed
.The measure of DPPH free radical scavenging activities is carried out to liver cancer healing liquid, DPPH clearance rates result is 96.8%.
Embodiment 9
Liver cancer healing liquid raw material (parts by weight)：100 parts of Lowiaceae plant extraction liquid, 20 parts of turmeric extracting solution.
The preparation method of the Lowiaceae plant extraction liquid is same as Example 2.
The preparation method of the turmeric extracting solution, includes the following steps：Turmeric is smashed it through into 20 mesh sieve, is added to temperature
For in 45 DEG C of water, the mass ratio of the turmeric and water is 1：10, ultrasonic extraction 60 minutes, the ultrasonic power of the ultrasonic extraction
It for 250W, supersonic frequency 40kHz, is centrifuged 30 minutes with 6000 revs/min of rotating speed, takes the supernatant liquid after centrifugation, cross 300
Mesh sieves, and retains filtrate to get turmeric extracting solution.
Each raw material is uniformly mixed i.e. by the preparation method of above-mentioned liver cancer healing liquid for 20 minutes by 300 revs/min of stirrings of rotating speed
.The measure of DPPH free radical scavenging activities is carried out to liver cancer healing liquid, DPPH clearance rates result is 88.6%.
Test case 1
The embodiment 1-2 and embodiment 5-9 liver cancer healing liquids prepared are subjected to treatment liver cancer efficacy test.
Totally 7 groups, every group of 20 liver cancer middle and advanced stage patients, wherein 10 people of male, 10 people of women, age 32-65 Sui.
Liver cancer symptom has：Hepatalgia, receive it is poor, become thin, weak and unknown cause fever, abdominal distension, diarrhea, jaundice
Deng.Even symptom of digestive tract often shows as stomach and receives decline, after meal Abdeminal pain, Nausea and vomiting or diarrhea.It is and general with fever
Even up to 39 DEG C or more at 37.5 DEG C -38 DEG C or so, in irregular heat type, mostly not with shiver with cold, fever in the afternoon is more typical, sometimes
Also show tension and relaxation type high fever.The course of disease is 0.5-1.
Take liver cancer healing liquid of the present invention 360 days, early, middle and late daily once a dose, each taking 2 milli of liver cancer healing liquid
It rises.
Criterion of therapeutical effect：
(1) it fully recovers：Symptom, sign completely disappear；
(2) effectively：Symptom is substantially reduced, and sign is clearly better；
(3) it is invalid：Pretherapy and post-treatment non-evident sympton improves or aggravates.
Specific test result is shown in Table 1.
Table 1：Therapeutic effect test result table
| Recovery from illness | Effectively | In vain | |
| Embodiment 1 | 1 | 13 | 6 |
| Embodiment 2 | 2 | 15 | 3 |
| Embodiment 5 | 0 | 14 | 6 |
| Embodiment 6 | 1 | 12 | 7 |
| Embodiment 7 | 1 | 15 | 4 |
| Embodiment 8 | 3 | 16 | 1 |
| Embodiment 9 | 0 | 13 | 7 |
Test case 2
Liver cancer healing liquid prepared by embodiment 3 is subjected to treatment lung cancer measure of merit.
Lung cancer 10, wherein male 5, women 5, age 40-65 Sui, disease of the illness common to respiratory disease
Shape, such as it is cough, phlegm blood, low-heat, pectoralgia, unhappy；Superior vena cava syndrome：Neck oedema, trachyphonia, shortness of breath, oedema, shoulder arm pain
Bitterly, it becomes thin, is weak.The course of disease is 0.5-1.Take liver cancer healing liquid of the present invention 360 days, early, middle and late daily once a dose, often
It is secondary to take 2 milliliters of liver cancer healing liquid.10 patients, 1 recovery from illness, 8 effectively, and 1 invalid.
Test case 3
Liver cancer healing liquid prepared by embodiment 4 is subjected to treatment breast cancer measure of merit.
Breast cancer women 10, age 35-50 Sui, illness is breast lump, and matter is hard, and edge is irregular, and surface owes smooth；
Non-pregnancy flows out blood, slurries, milk, fester from nipple；There are many small point-like recess in skin of mammary gland, just as orange peel one
Sample；Skin of nipple itch, erosion, ulceration, incrustation, furfur, companion's cusalgia, so that nipple bounces back.The course of disease is 1-2.Take this hair
Bright liver cancer healing liquid 360 days, it is daily it is early, middle and late once a dose, each taking 2 milliliters of liver cancer healing liquid.10 patients 2 fully recover from an illness
More, 8 effectively.
Claims (10)
1. a kind of liver cancer healing liquid, which is characterized in that including following weight parts raw material：95-105 parts of Lowiaceae plant extraction liquid, ginger
Yellow extracting solution 15-25 parts.
2. liver cancer healing liquid as described in claim 1, which is characterized in that further include following weight parts raw material：Rhizoma imperatae extract liquor
5-15 parts.
3. liver cancer healing liquid as claimed in claim 2, which is characterized in that further include following weight parts raw material：Chrysanthemum extract liquor 10-
20 parts.
4. liver cancer healing liquid as described in claim 1, which is characterized in that the preparation method of the Lowiaceae plant extraction liquid, including
Following step：
(1) 30-50g bananas bark is added in 60-200g boiling water and scalded 3-8 minutes, drain surface moisture, then by 20-40g perfume
Any of several broadleaf plants bark, 25-50g Banana trees stem, 10-20g bananas leaf are 6-12 hours dry at 40-60 DEG C, by banana bark, Banana tree
Stem, banana leaf smash it through 20-50 mesh sieve respectively, are uniformly mixed that obtain mixture spare；
(2) 12-36g mixtures are taken, are added to the aqueous sodium chloride that 40-80g mass fractions are 3-10%, temperature is 35-55 DEG C
In liquid, ultrasonic extraction 35-65 minutes under the conditions of power is 200-800W, frequency is 40-50KHz, with 4000-10000 revs/min
The rotating speed of clock centrifuges 20-60 minutes, takes the supernatant liquid after centrifugation, crosses 100-500 mesh sieve, retains filtrate to get Lowiaceae plant
Extract liquor.
5. liver cancer healing liquid as described in claim 1, which is characterized in that the preparation method of the Lowiaceae plant extraction liquid, including
Following step：
(1) 30-50g bananas bark is added in 60-200g boiling water and scalded 3-8 minutes, drain surface moisture, then by 20-40g perfume
Any of several broadleaf plants bark, 25-50g Banana trees stem, 10-20g bananas leaf are 6-12 hours dry at 40-60 DEG C, by banana bark, Banana tree
Stem, banana leaf smash it through 20-50 mesh sieve respectively, are uniformly mixed and obtain mixture, by mixture in -45~-40 DEG C of freezings
30-90 minutes, then with power is 300-500W, microwave heating that frequency is 2450-3000MHz 5-25 minutes, -35~-
30 DEG C freeze 20-60 minutes, then with power is 300-500W, microwave heating that frequency is 2450-3000MHz 5-20 minutes,
It is freezed 10-40 minutes at -25~-20 DEG C, then with the microwave heating 3- that power is 300-500W, frequency is 2450-3000MHz
It 15 minutes, is then placed 30-90 minutes in 30-60 DEG C of insulating box, the mixture pre-processed；
(2) 12-36g mixtures are taken, are added to the aqueous sodium chloride that 40-80g mass fractions are 3-10%, temperature is 35-55 DEG C
In liquid, ultrasonic extraction 35-65 minutes under the conditions of power is 200-800W, frequency is 40-50KHz, with 4000-10000 revs/min
The rotating speed of clock centrifuges 20-60 minutes, takes the supernatant liquid after centrifugation, crosses 100-500 mesh sieve, retains filtrate to get Lowiaceae plant
Extract liquor.
6. the liver cancer healing liquid as described in claim 1 or 5, which is characterized in that the preparation method of the turmeric extracting solution, including under
State step：Turmeric is smashed it through into 20-50 mesh sieve, is added in the water that temperature is 35-55 DEG C, is added and help extractant, it is described
The mass ratio of turmeric and water is 1：(5-15), described to help extractant and the mass ratio of turmeric be 1：(5-15), ultrasonic extraction 50-70
Minute, the ultrasonic power of the ultrasonic extraction is 150-350W, supersonic frequency 25-45kHz, with 4000-8000 revs/min
Rotating speed centrifuges 20-60 minute, takes the supernatant liquid after centrifugation, crosses 100-500 mesh sieve, reservation filtrate to get.
7. liver cancer healing liquid as claimed in claim 6, it is characterised in that；It is described help extractant for citric acid monoglyceride and/or
Propylene glycol alginate.
8. liver cancer healing liquid as claimed in claim 2, which is characterized in that the preparation method of the rhizoma imperatae extract liquor, including under
State step：Rhizoma imperatae is smashed it through into 20-50 mesh sieve, is added to the sodium chloride that mass fraction is 2-7%, temperature is 40-50 DEG C
In aqueous solution, the mass ratio of the rhizoma imperatae and sodium-chloride water solution is 1：(5-15), ultrasonic extraction 50-70 minutes are described super
The ultrasonic power of sound extraction is 150-350W, supersonic frequency 25-45kHz, and 20- is centrifuged with 4000-8000 revs/min of rotating speed
60 minutes, take the supernatant liquid after centrifugation, cross 100-500 mesh sieve, retain filtrate to get.
9. liver cancer healing liquid as claimed in claim 3, which is characterized in that the preparation method of the chrysanthemum extract liquor, including following
Step：Chrysanthemum is smashed it through into 20-50 mesh sieve, is added in the water that temperature is 60-80 DEG C, the mass ratio of the chrysanthemum and water is
1：(5-15), ultrasonic extraction 50-70 minutes, the ultrasonic power of the ultrasonic extraction is 150-350W, supersonic frequency 25-
45kHz is centrifuged 20-60 minutes with 4000-8000 revs/min of rotating speed, takes the supernatant liquid after centrifugation, crosses 100-500 mesh sieve,
Retain filtrate to get.
10. the preparation method of liver cancer healing liquid as described in any one of claim 1-9, which is characterized in that by each raw material with turn
Speed is uniformly mixed for 10-30 minutes for 200-500 revs/min of stirring to obtain the final product.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108339062A (en) * | 2018-05-22 | 2018-07-31 | 北京康芬中医药研究院 | Lung cancer healing liquid and preparation method thereof |
| CN108671202A (en) * | 2018-07-26 | 2018-10-19 | 广西中绿医药科技有限公司 | Prostate cancer healing liquid and preparation method thereof |
| CN108686060A (en) * | 2018-07-26 | 2018-10-23 | 广西中绿医药科技有限公司 | A kind of lymph cancer healing liquid and preparation method thereof |
| CN109674990A (en) * | 2019-01-30 | 2019-04-26 | 中国人民解放军西部战区总医院 | With the composition and preparation method thereof for adjusting EGFR effect |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108339062A (en) * | 2018-05-22 | 2018-07-31 | 北京康芬中医药研究院 | Lung cancer healing liquid and preparation method thereof |
| CN108671202A (en) * | 2018-07-26 | 2018-10-19 | 广西中绿医药科技有限公司 | Prostate cancer healing liquid and preparation method thereof |
| CN108686060A (en) * | 2018-07-26 | 2018-10-23 | 广西中绿医药科技有限公司 | A kind of lymph cancer healing liquid and preparation method thereof |
| CN109674990A (en) * | 2019-01-30 | 2019-04-26 | 中国人民解放军西部战区总医院 | With the composition and preparation method thereof for adjusting EGFR effect |
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Application publication date: 20180615 |