CN109769815A - A kind of new application of Paeonol - Google Patents
A kind of new application of Paeonol Download PDFInfo
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- CN109769815A CN109769815A CN201910154744.1A CN201910154744A CN109769815A CN 109769815 A CN109769815 A CN 109769815A CN 201910154744 A CN201910154744 A CN 201910154744A CN 109769815 A CN109769815 A CN 109769815A
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- chinese medicine
- paeonol
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Abstract
The present invention relates to a kind of for preventing and treating the compound paeonolum of Chinese medicine storage pest, structural formula such as formula (I), to Chinese medicine storage pest tag and repellent activity.Abundant raw material of the invention, simple production process, production cost is low, good to the control efficiency of Chinese medicine storage pest, is expected to exploitation into green bio pesticide.
Description
Technical field
The present invention relates to the application of the new application of Paeonol more particularly to Paeonol in prevention and treatment Chinese medicine storage pest.
Background technique
Chinese medicine is with a long history, is the Chinese nation for thousands of years with the wisdom crystallization formed during disease struggle, is China
Or even world medicine is made that huge contribution.In recent years, with traditional Chinese medicine in China's medical system status continuous rising,
National to have put into effect " traditional Chinese medicine health service development plan (2015-2020) " in succession in the recent period, " Chinese medicine developmental strategy plans guiding principle
Take (2016-2030) " etc. policies.In addition, the acquisition of the Chinese first natural science field Nobel Prize, greatly push
The development of Medico-International.It can be seen that Chinese Medicine Industry will welcome new development opportunity, demand of the world to Chinese medicine can be into one
Step increases, and Chinese Medicine Industry will make huge contribution to the national economic development, human health.
But some problems present in Chinese Medicine Industry restrict its development.China's Chinese medicine is due to pest and disease damage of storing in a warehouse
Prevent and treat it is improper caused by economic loss up to billions of members, in addition to this, storage pest and disease damage has seriously affected the medication of tcm clinical practice
Safety.Chinese medicine forms hole after being damaged by insects, or even by moth powdering, not only medicinal material weight is reduced, but also medicinal material curative effect is also big
Big reduce even is lost, and frass, worm corpse and secretion can breed pathogenic bacteria, mould etc., is polluted medicinal material, is caused to the health of human body
It threatens.According to investigations, cause harm the storage pest up to more than 200 of Chinese medicine, there are about 70% in 600 common several kinds of Chinese medicinal materials of the whole nation
Can insect infestation, it is annual caused by economic loss reach several hundred million members, the drug safety and Chinese medicine for seriously affecting tcm clinical practice are in the world
Competitiveness in the market.Therefore, Chinese medicine storage control of insect work is carried out to promote safety, the validity for ensuring Chinese medicine
Have great importance into traditional Chinese medicine sustainable development and internationalization.
Although production, the operation of drug have a series of specifications, such as: " Chinese medicine at present to the plantation of Chinese medicine, processing
Quality of production management regulation " (GAP), " pharmaceutical production quality management practices " (GMP) and Pharmacy Business Quality Management Regulations
(GSP), but to the storage process of Chinese medicine lack specification, therefore, the Chinese medicine storage prevention and control of plant diseases, pest control is thin in Chinese Medicine Industry
Weak link is the modernization of Chinese medicine, the bottleneck in international development.
The pest and disease damage of Chinese medicine storage at present uses long-term, excessive use based on the stifling chemical preventions such as sulphur, aluminum phosphate
Chemical pesticide causes the problems such as residual exceeded, the pest resistance to insecticide increase of agriculture and environmental pollution, and the Chinese medicine safety problem thus caused
Also result in extensive concern.Therefore safe and environment-friendly storage pest Prevention Technique is developed, will will be guarantee Chinese medicine yield and product
Matter promotes Chinese Medicine Industry sustainable development to be of great significance.In this context, traditional Chinese medicine maintenance process " storage methord
Method " causes the extensive concern of people, the method mainly using it is some have special odor, the medicinal material with expelling parasite mildew-proof function with
Easy infested mouldy medicinal material is store altogether, achievees the purpose that prevent medicinal material infested mouldy.This method not can cause environmental pollution, to people
It is lower with the toxicity of animal, it is simple and easy to do, particularly suitable for the storage of a small amount of medicinal materials, easily receive for people.It is inspired by this, people couple
The research of control of insect is gradually transferred to from natural plants and looks for anti-insect activity ingredient, is prevented and treated and is stored in a warehouse using botanical components
Pest meets the environmentally protective trend trend in the world to achieve the purpose that bionomic control.
China's plant resources rich biodiversity, is the big country of natural resources of Chinese medicinal materials quantum of output and consumption, but the plant in China
Goods and materials source utilization rate is low.Cortex moutan such as China is resourceful, and phenolic compound paeonol content is high, and natural Paeonol is in state
Price is much higher than synthetic in the market on border.And remove part and exported for medicinal material, most of cortex moutan is not all utilized, makes
At the wasting of resources (Sun Zhifeng root bark of tree peony phenol extraction and the pharmacology activity research progress Guangdong chemical industry .2016；43).If making full use of me
The local products resource of state extracts Paeonol and simultaneously stores in a warehouse control of insect for Chinese medicine, then not only can solve the harm of storehouse worm but also can be with
The plant resources for making full use of waste, achieve the purpose that comprehensive utilization of resources.
Cortex moutan is the dry root skin of ranunculaceae peony (Paeonia moutan Sim.), and property is bitter, pungent, slightly cold, returns
The heart, liver and kidney channel.Have the function of clearing heat and cooling blood, activating microcirculation and removing stasis medicinal, is mainly used for febrile virulent maculae, haematemesis, night fever abating at dawn, lossless bone
(Yang little Long, Zhang Ke, Xu Junfeng, Wang Zhichao cortex moutan pharmacological action are ground for steaming, dysmenorrhoea menostasis, carbuncle sore tumefacting virus, the pain of injury caused by falling and tumbling etc.
Study carefully progress University Of Science and Technology Of He'nan journal (medicine report) .2012；30(2)).Studies have shown that its phenolic compound paeonol structure formula
Are as follows:
It has the effects that antibacterial anti-inflammatory, analgesia, antipyretic, spasmolysis, antiallergy, activating microcirculation and removing stasis medicinal, enhancing immune function (Sun Zhi
Peak root bark of tree peony phenol extraction and the pharmacology activity research progress Guangdong chemical industry .2016；43.).
Summary of the invention
The purpose of the present invention is to provide the new applications of Paeonol prevention and treatment Chinese medicine storage pest.Paeonol is used for centering
The prevention and treatment of medicinal material storage pest lasioderma serricorne, red flour beetle, there is preferable control efficiency.
The compound has low toxicity, low-residual, low cost, green safe characteristic, can be using its bioactivity to main
Chinese medicine storage pest is prevented and treated.
The invention has the following advantages that
1, compound paeonolum abundant raw material according to the present invention, simple production process.
2, purposes of the present invention is used for the prevention and treatment of Chinese medicine storage pest, to Chinese medicine storage pest lasioderma serricorne, red flour beetle
There is good control efficiency.
3, purposes of the present invention has low toxicity, low-residual, low cost, green safe characteristic, is expected to exploitation into green ecological
Pesticide.
Specific embodiment
Structural Identification
Compound: Paeonol
White, needle-shaped crystals, molecular formula C9H10O3,1H-NMR(DMSO-d6)δ(ppm):2.57(3H,s.-COCH3),3.83
(3H,s.OCH3), 6.45~6.60 (2H, m.H-4,6), 7.85 (1H, d.J=8.8Hz, H-3), 12.64 (1H, s.OH)；13C-
NMR(DMSO-d6)δ(ppm):164.6(C-1),114.2(C-2),133.8(C-3),107.7(C-4),166.2(C-5),
101.2(C-6),56.2(-OCH3), 203.6 (C=O), 27.1 (- CH3).By the nuclear magnetic data of the compound and " Chemistry for Chinese Traditional Medicine
Reference substance operation manuals " in report1H-NMR and13C-NMR data are compared, and determine that compound is Paeonol.Pharmacodynamics examination
Test research
1, contact toxicity test method
Paeonol is described in reference literature the test method of lasioderma serricorne contact toxicity: by the adult to sprout wings one week or so from
It is taken out in culture bottle, prepares the Paeonol acetone dilution of 5 various concentrations, with 0.5 μ L of liquid-transfering gun drop in the shirtfront of test worm
It (being placed on ice bag and operates) on backboard, be put into diameter 2.5cm after processing, in high 5.5cm vial, acetone is blank control group,
Each concentration is repeated 5 times, 10 test worms of each repetition.It is (29 ± 1) DEG C that processing group and control group, which are placed in temperature, and relative humidity is
It is cultivated in the constant incubator of (75 ± 5) % for 24 hours, the death condition of observation and record test worm calculates LD50 by the death rate.
LD50 value uses Probit (IBM SPSS V20.0) analytical calculation.
Experimental drug: compound paeonolum according to the present invention；
Positive control drug: pyrethrins；
It the results are shown in Table 1.
Contact toxicity of 1. Paeonol of table to lasioderma serricorne and red flour beetle
2, repellent activity test method:
Paeonol is the circle for being 9cm by diameter to the specific test method of the repellent activity of lasioderma serricorne and red flour beetle
It is two halves that shape filter paper is cut out from centre, draws 500 μ L Paeonol acetone dilutions (5 concentration of setting: 78.63, with liquid-transfering gun
15.73,3.15,0.63 and 0.13nL/cm2,5 repetitions of each concentration) for drop on wherein half filter paper, the other half uses solvent third
Ketone processing is handled as blank control, and naturally dry 30s is pasted onto culture dish bottom in opposite directions with solid gum and (carries out lasioderma serricorne
When repellent activity is tested, culture dish ware wall need to coat polytetrafluoroethylene (PTFE)).20 test worms are poured into culture dish center, are observed and recorded
The distribution situation for handling when 2h and 4h and compareing test worm on filter paper, calculates scattering ratio PR (%), formula is as follows:
PR (%)=[(Nc-Nt)/(Nc+Nt)] × 100
Nc is the quantity of test worm on blank control filter paper, and Nt is the quantity of test worm on administration group filter paper.Utilize SPSS software
It carries out independent double sample t and examines to walk quickly and keep away rate to analyze Paeonol and Metadelphene to lasioderma serricorne, red flour beetle to rate is averagely walked quickly and kept away
Mean value whether there is significant difference.
Experimental drug: compound paeonolum according to the present invention；
Positive control drug: Metadelphene；
It the results are shown in Table 2, table 3.
2. Paeonol of table is in 2h to the scattering ratio (PR% ± SE) of lasioderma serricorne, red flour beetle
Note: significant difference (p < 0.05) between the different alphabetical expression processing of same column
3. Paeonol of table is in 4h to the scattering ratio (PR% ± SE) of lasioderma serricorne, red flour beetle
Note: significant difference (p < 0.05) between the different alphabetical expression processing of same column
Conclusion: the above experimental result shows that the compounds of this invention Paeonol has storage pest lasioderma serricorne and red flour beetle
There is fabulous control efficiency, can be found by both the above model insects, the compounds of this invention Paeonol can be used for storage pest
Prevention and treatment.
The foregoing describe the preferred embodiment for the present invention, and however, it is not to limit the invention.Those skilled in the art couple
Embodiment disclosed herein can carry out the improvements and changes without departing from scope and spirit.
Claims (2)
1. application of the Paeonol with following structural formula (I) in prevention and treatment Chinese medicine storage pest.
2. application as described in claim 1, it is characterised in that the Chinese medicine storage pest includes lasioderma serricorne, red flour beetle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910154744.1A CN109769815A (en) | 2019-03-01 | 2019-03-01 | A kind of new application of Paeonol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910154744.1A CN109769815A (en) | 2019-03-01 | 2019-03-01 | A kind of new application of Paeonol |
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| Publication Number | Publication Date |
|---|---|
| CN109769815A true CN109769815A (en) | 2019-05-21 |
Family
ID=66487304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910154744.1A Pending CN109769815A (en) | 2019-03-01 | 2019-03-01 | A kind of new application of Paeonol |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104430580A (en) * | 2014-12-10 | 2015-03-25 | 甘肃惠森药业发展有限公司 | Traditional Chinese medicinal material stored pest repellent |
-
2019
- 2019-03-01 CN CN201910154744.1A patent/CN109769815A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104430580A (en) * | 2014-12-10 | 2015-03-25 | 甘肃惠森药业发展有限公司 | Traditional Chinese medicinal material stored pest repellent |
Non-Patent Citations (6)
| Title |
|---|
| 刘本臣: ""丹皮酚的研究进展"", 《中草药》 * |
| 夏传国 等: ""丹皮及其提取物对几种中药材仓储害虫的忌避作用研究"", 《粮食储藏》 * |
| 夏传国等: ""丹皮提取物和丹皮酚对几种中药材害虫的毒杀作用研究"", 《仲恺农业技术学院学报》 * |
| 张青文，刘小侠主编: "《农业入侵害虫的可持续治理》", 30 April 2013 * |
| 李隆术，朱文炳编著: "《储藏物昆虫学》", 31 March 2009 * |
| 范文昌: "《封丘金银花》", 31 July 2014 * |
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Application publication date: 20190521 |
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