CN109765282A - Medical magnesium alloy implant devices multifactor dynamic degradation performance evaluation device in vitro - Google Patents
Medical magnesium alloy implant devices multifactor dynamic degradation performance evaluation device in vitro Download PDFInfo
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- 238000006731 degradation reaction Methods 0.000 title claims abstract description 56
- 230000015556 catabolic process Effects 0.000 title claims abstract description 52
- 229910000861 Mg alloy Inorganic materials 0.000 title claims abstract description 37
- 239000007943 implant Substances 0.000 title claims abstract description 32
- 238000000338 in vitro Methods 0.000 title claims abstract description 15
- 238000011156 evaluation Methods 0.000 title claims abstract description 14
- 239000002904 solvent Substances 0.000 claims abstract description 53
- 241000894006 Bacteria Species 0.000 claims abstract description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 13
- 239000008103 glucose Substances 0.000 claims abstract description 12
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 11
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims description 79
- 238000012360 testing method Methods 0.000 claims description 31
- 239000007789 gas Substances 0.000 claims description 17
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 230000033228 biological regulation Effects 0.000 claims description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
- 239000001569 carbon dioxide Substances 0.000 claims description 8
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 230000007797 corrosion Effects 0.000 abstract description 18
- 238000005260 corrosion Methods 0.000 abstract description 18
- 239000012890 simulated body fluid Substances 0.000 abstract description 12
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 abstract description 5
- 239000000523 sample Substances 0.000 description 29
- 239000000243 solution Substances 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 10
- 230000003068 static effect Effects 0.000 description 10
- 239000010839 body fluid Substances 0.000 description 8
- 210000001124 body fluid Anatomy 0.000 description 8
- 239000000463 material Substances 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000011777 magnesium Substances 0.000 description 4
- 229910052749 magnesium Inorganic materials 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000004088 simulation Methods 0.000 description 3
- 230000006399 behavior Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 241001269238 Data Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000000157 electrochemical-induced impedance spectroscopy Methods 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 238000001453 impedance spectrum Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
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- Testing Resistance To Weather, Investigating Materials By Mechanical Methods (AREA)
Abstract
Medical magnesium alloy implant devices multifactor dynamic degradation performance evaluation device in vitro, the outer constant temperature dynamic analog environment of lower medical magnesium alloy implant devices analogue body different in flow rate is realized in the synergy that the device passes through immersible pump, flowmeter, sample slot, thermostat, reservoir, pipeline and computer, controls air valve by computer and solvent valve provides oxygen, carbon dioxide, protein, glucose, bacterium, acidity and alkaline totally seven influence factors individually act on or the external multifactor simulated body fluid environment of multiple synergy；The variation of the pH and temperature in its external Dynamic Corrosion degradation process are monitored using pH meter and thermometer；Its dynamic degradation rate is characterized roughly using the pH value of software analysis variation, its degradation property is analyzed using the synergy of computer and electrochemical workstation, a possibility that providing a kind of reliable and stable device for the external dynamic degradation performance evaluation of medical magnesium alloy implant devices, improve magnesium alloy medical industrialization.
Description
Technical field
The present invention relates to the medical device degradation property analytical equipments under the simulation more influence factor true environments of human body, definitely
It is medical magnesium alloy implant devices multifactor dynamic degradation performance evaluation device in vitro that ground, which is said,.
Background technique
Magnesium elements have good bio-compatible as important element necessary to participating in body material's synthesis and being metabolized
Property, and possess the density and mechanical property close with human Cortex's bone, thus just cause plastic surgery and bone early in early 20th century
The attention of section medical worker.Its unique internal degradation characteristic can be effectively prevented from traditional secondary hand of internal fixation device part bring
Art, therefore it is considered as most promising artificial orthopaedics alternate material.However, clinical research has been found that magnesium and magnesium alloy implant devices mistake
Fast internal corrosion rate makes magnesium alloy implant devices in a short time and will appear mechanical property rapid drawdown, to be difficult to maintain to create
The medium conduction that the biomethanics necessary to closing that recovers from injury support and tissue growth are relied on, while bubble can be subcutaneously gathered rapidly,
These factors become all the time limits its key reason for being widely used in clinic as medical embedded device.
In recent years, the research of medical magnesium alloy device and application achieve rapid development, and domestic and international researcher is in order to more
Its corrosion degradation feature and corrosion degradation mechanism are in depth dissected, solution medical magnesium alloy implant devices degradation rate is too fast to be lacked
It puts and proposes the method and device of a large amount of medical magnesium alloy implant devices external degradation performance evaluation.Compared in vivo studies
And clinical research, in vitro test more can quickly and intuitively it is concluded that, and feed back into vivo studies and clinical research, together
When in vitro test have low cost, Gao Shixiao, controllability strong and many advantages, such as analysis means are diversified, also can avoid certain human relations
The generation of the question of morality is managed, therefore researchers at home and abroad are generally used in vitro test and come to medical magnesium alloy implant devices
Corrosive degradation can be carried out analysis.
However, the research multi-focus of in vitro test at present is tested in external static immersing, also there is the external dynamic test in part.
External static immersing test is exactly that medical magnesium alloy implant devices are simply placed on static immersing in simulated body fluid, is divided according to this
The external degradation performance for analysing magnesium alloy implant devices, further speculates it in inside of human body degradation property；Such external static state
Soak test can not simulate true particular surroundings in human body completely, often have ignored isoperibol and body fluid flowing pair in human body
The corrosion degradation of medical magnesium alloy implant devices influences, and also has ignored other material factors in human body fluid to its degradation property
Influence, especially the existing factor of protein, glucose, bacterium, acid-base property, oxygen and carbon dioxide to medical magnesium alloy plant
The degradation for entering device influences, while static immersing test can not analyze during external corrosion degradation simulated body fluid at device under test
Temperature, pH value and its electrochemical properties variation, simply evaluate its external static drop only by liberation of hydrogen method or weight-loss method
Solve rate；Static immersing test expends a large amount of human and material resources and time but without good degradation analysis result.And existing portion
Seperated outer dynamic test typically only merely provides circulating for simulated body fluid, and there is no in fully simulated body fluid
The true environment in portion has ignored human body fluid internal protein, glucose, bacterium, acid-base property, oxygen, carbon dioxide and constant temperature ring
Border, which degrades on the Dynamic Corrosion of medical magnesium alloy implant devices, to be influenced, it is also difficult to be analyzed to be measured in external Dynamic Corrosion degradation process
The temperature, pH value of simulated body fluid and its variation of electrochemical properties at device；Dynamic test has the actual environment of flowing, but
Or the practical fluid environment of human body cannot be simulated completely, body fluid has been analyzed unilaterally and has flowed the shadow degraded to medical magnesium alloy
It rings, has ignored influence of other substances to its degradation property, there is certain error.
Summary of the invention
The present invention overcomes the disadvantages mentioned above of the prior art, provides medical magnesium alloy implant devices multifactor dynamic degradation in vitro
Performance evaluation device.
Medical magnesium alloy implant devices of the invention multifactor dynamic degradation performance evaluation device in vitro, it is characterised in that:
Ground is equipped with computer 1, electrochemical workstation 2, the first storage cylinder 3, the second storage cylinder 4, thermostat 9, reservoir 10, first
Liquid reserve tank 21, the second liquid reserve tank 22, third liquid reserve tank 23, the 4th liquid reserve tank 24, the 5th liquid reserve tank 25, flowmeter 27, sample slot
30, immersible pump 31；Reservoir 10 is located in thermostat 9, and the water outlet of the immersible pump 31 of 10 bottom of reservoir is connected by pipeline 26
Flowmeter 27 and sample slot 30 are connect, the water outlet of sample slot 30 connects reservoir 10 by pipeline, forms liquid circulation loop；Storage
Liquid bath 10 is separately connected the first storage cylinder 3 and the second storage cylinder 4, reservoir by the first gas pipeline 7 and the second gas pipeline 8
10 pass through the first liquid-transport pipe-line 11, the second liquid-transport pipe-line 12, third liquid-transport pipe-line 13, the 4th liquid-transport pipe-line 14 and the 5th perfusion tube
Road 15 is separately connected the first liquid reserve tank 21, the second liquid reserve tank 22, third liquid reserve tank 23, the 4th liquid reserve tank 24 and the 5th liquid reserve tank
25；Computer 1 is separately connected the control terminal of the first air valve 5 and the second air valve 6 by the first control line 34 and the second control line 35,
Output and output quantity regulation to oxygen and carbon dioxide in the first storage cylinder 3 and the second storage cylinder 4；Computer 1 passes through the
Three control lines 38, the 4th control line 39, the 5th control line 40, the 6th control line 41 and the 7th control line 42 respectively with the 5th solution
Valve 20, the 4th solvent valve 19, third solvent valve 18, the second solvent valve 17 are connected with the control terminal of the first solvent valve 16, to each storage
The output of protein, glucose, bacterium, sodium hydroxide and citric acid solution inside liquid case and output quantity regulation；
Electrochemical workstation 2 by p-wire 44 with inside sample slot 30 electrode 33 and device under test 32 connect, it is electrochemical
Work station 2 is learned also to connect by third data line 45 with computer 1；
The control terminal of immersible pump 31 connects computer 1 by the 8th control line 43, and computer 1 regulates and controls liquid in pipeline 26
Flow velocity；
PH meter 28 and thermometer 29 are housed, the signal output end of pH meter 28 and thermometer 29 is respectively with first on sample slot 30
Data line 36 and the second data line 37 connect computer 1.
Further optimal technical scheme is as follows:
The computer is common PC machine or laptop, can external control line and data line, and there is drop
Solve performance evaluation and rate processing software or program.
The electrochemical workstation is a kind of three-electrode electro Chemical work station that can be monitored on-line, can connect computer.
The storage cylinder is general cylindrical form storage cylinder, internal to store oxygen and carbon dioxide gas, top respectively
Opening can external electric-air valve.
The air valve is adjustment type electric-air valve, has good airtightness, can be connected to storage cylinder, can connect meter outside
Calculation machine.
The gas pipeline is circular hard plastic pipe, can connect air valve, can protrude into inside reservoir.
The thermostat is a kind of common constant temperature water bath, and inside can place reservoir, is existed convenient for pipeline connection
Through-hole.
A kind of preferable rectangular closed slot of heat transfer property of the reservoir has preferable mechanical property and heat insulating ability
Can, storage inside simulated body fluid can place immersible pump and multiple pipelines, there is the through-hole convenient for pipeline connection.
The liquid-transport pipe-line is circular hard plastic pipe, has preferable corrosion resistance, can connect molten
Liquid valve can protrude into inside reservoir and liquid reserve tank.
The solvent valve is the electrically powered liquid valve of adjustment type, has good sealing performance and preferable corrosion resistance
Can, it can be connected to liquid reserve tank, computer can be connect outside
The liquid reserve tank is a kind of rectangular box of sealing, has preferable corrosion resistance, and albumen is stored in inside respectively
Matter, glucose, bacterium, sodium hydroxide and citric acid solution, top can fixed solution valves.
The pipeline is a kind of silica gel hose that thermal insulation property is fabulous, inside be circular hole.
A kind of numerical display type flowmeter of the flowmeter.
The pH meter is a kind of contact pH meter, and fixed placement can be connect on sample slot with computer.
The thermometer is a kind of contact tehermometer, and fixed placement can be connect on sample slot with computer.
The sample slot is a kind of sealed rectangular slot with thermal insulation property, and upper part can place pH meter and thermometer,
The through-hole that the right and left exists convenient for pipeline connection, inside can store device under test and electrode.
The immersible pump is a kind of small-sized adjustable speed immersible pump, can connect computer；It can put into liquid, have preferable
Corrosion resistance and sealing performance.
The device under test is a kind of medical magnesium alloy implant devices to be tested.
The electrode is a kind of dedicated test electrode of electrochemical workstation, be can be placed on sample slot.
The control line is a kind of cable of executable control manipulation, can be used for connecting computer.
The p-wire is a kind of dedicated p-wire of electrochemical workstation, can be used for connection electrode and device under test.
The data line is a kind of cable of data transmission, can be used for connecting computer.
The present invention is provided by immersible pump, flowmeter, sample slot, thermostat, reservoir, pipeline and computer collective effect
The external dynamic flow simulation environment of medical magnesium alloy implant devices connects immersible pump by computer and carries out regulation realization to simulation
The controllability different in flow rate of body fluid, flowmeter show real-time flow rate, solve general external static immersing test without analogue body
The problem of liquid dynamic circulation；It ensure that stable external constant temperature using the synergy of thermostat and reservoir, provide
The true constant temperature fluid environment of human body；Two air valves are connected using computer to realize to the oxygen and carbon dioxide in two storage cylinders
Output and its output quantity size regulated and controled, provide true environment existing for oxygen and carbon dioxide in human body fluid, just
In the presence and its amount size for probing into oxygen and carbon dioxide to the external dynamic degradation performance of medical magnesium alloy implant devices
Influence；The protein solution realized in five liquid reserve tanks, glucose solution, thin is connect with five solvent valves using computer
Bacterium solution, the output of sodium hydroxide solution and citric acid solution and its output quantity size are regulated and controled, and are provided in human body fluid
Protein, glucose, the acidity of bacterium necessary being or alkaline environment, convenient for probe into protein, glucose, bacterium presence and
Influence of its amount size to the external dynamic degradation performance of medical magnesium alloy implant devices, can also study different acid-base property pair
The influence of its degradation property；By computer control air valve and solvent valve can provide oxygen, carbon dioxide, protein, glucose,
Totally seven influence factors individually act on or the external multifactor simulated body fluid environment of multiple synergy for bacterium, acidity and alkalinity,
It can study that above-mentioned seven kinds of influence factors individually act on or multiple synergy are to the external dynamic degradation of medical magnesium alloy implant devices
The influence of performance.
The present invention connects pH meter and thermometer after providing above-mentioned multifactor impact environment, using computer to monitor point
The real-time change of pH and temperature during the analysis external dynamic degradation of medical magnesium alloy implant devices, utilize computer software analysis
The varying ph being collected into is inferred to roughly the variation of its degradation rate；Computer is utilized and combines work with electrochemical workstation
The mode of work, electrochemical workstation are connect by p-wire with electrode and device under test, realize medical magnesium alloy implant devices body
The real-time monitoring and collection of various electrochemical datas during outer dynamic degradation, then connect by data line with computer, it will
The data information transfer of acquisition to computer, using on computer processing software (Zview2 software, CVIEW2 software,
ZSimpWin software and Croshow software etc.) collected electrochemical data information is analyzed and processed, then it is soft by computer
The analysis to its Dynamic Corrosion degradation property is completed in the electrochemical impedance spectrum analysis of part and the analysis of dynamic polarization curve, and then is passed through
The accurate value and variation for speculating its dynamic degradation rate of computer software.
The present invention provides oxygen, carbon dioxide, protein, glucose, bacterium, acid by the collective effect of above-mentioned component
Property and the multifactor constant temperature dynamic degradation environment of alkalinity, complete monitoring and the analysis to pH during dynamic degradation and temperature, benefit
The variation of monitored pH value is analyzed with computer software, intuitively roughly characterizes its dynamic degradation rate；Utilize calculating
Machine and electrochemical workstation are analyzed and are monitored to its dynamic degradation performance, extrapolate it by the way that computer software is accurate
Degradation rate realizes the function of medical magnesium alloy implant devices multifactor dynamic degradation performance evaluation in vitro, closes for medical magnesium
The external multifactor dynamic degradation performance evaluation of golden implant devices provides a kind of reliable and stable device, greatly improves magnesium
A possibility that alloy implant devices medical industrialization.
The invention has the advantages that
(1) it is realized by the collective effect of immersible pump, flowmeter, sample slot, thermostat, reservoir, pipeline and computer
In-vitro simulated body fluid circulate and flow velocity is controllable, solve general external static immersing test and ignore truth lower body
Liquid stream is dynamic on the problem of Corrosion Behaviors of Magnesium Alloys degradation property and rate influence, increases lower external Dynamic Corrosion different in flow rate and degraded
The controllable demand of flow velocity of journey test.
(2) by the way that thermostat and reservoir is applied in combination, the condition of the isoperibol of external dynamic analog body fluid is realized,
Reduce the test of external static immersing ignore human body isoperibol to Corrosion Behaviors of Magnesium Alloys degradation property bring error, increase
The measurement accuracy of device.
(3) two air valves are controlled by computer and five solvent valves provides oxygen, carbon dioxide, protein, grape
Sugar, bacterium, acidity and alkalinity totally seven influence factors individually act on or multiple synergy under external multifactor simulated body fluid
Environment improves device provided with the influence under controllable Multiple factors environment to medical magnesium alloy implant devices degradation property
Completeness and reliability.
(4) pH meter and thermometer are connected by using computer, during realizing the external corrosion degradation of device under test
The monitoring of pH and temperature, the diversity of data can be analyzed by increasing device.
(5) electrochemical workstation is connected by using computer, it is rotten realizes electrochemical workstation device under test dynamic
The timely transmission for losing the Electrochemistry Information and data real-time measurement and electrochemical data information in degradation process, improves corrosion
The accuracy of degradation property analysis, saves a large amount of manpowers and time.
(6) using on computer processing software and program data that degradation process is acquired and information handle, make
The pH value for surveying variation is analyzed with computer software, deduces its degradation rate roughly；Utilize electrochemical impedance spectroscopy point
Analysis software and dynamic polarization curve analyze software to analyze its dynamic degradation performance, between completing its degradation rate accurately
Calculating is connect, the completeness and accuracy of device performance analysis are improved.
(7) whole device is combined closely with computer, has a degree of automation, is additionally arranged medical magnesium alloy implantation
Multiple influence factors of device dynamic degradation, substantially increase the flexibility and applicability of such device, for setting for such device
Meter provides a kind of brand-new thinking, has saved a large amount of manpower and material resources, for the device be widely popularized provide it is certain
Possibility.
Detailed description of the invention
Fig. 1 is the axonometric drawing of apparatus of the present invention.
Fig. 2 is the top view of apparatus of the present invention.
Fig. 3 is the floor map of apparatus of the present invention.
Fig. 4 is the section view axonometric drawing of another angle of apparatus of the present invention.
Fig. 5 is 30 cross-sectional view of thermostat 9, reservoir 10 and sample slot of apparatus of the present invention.
Fig. 5 a is the portion the A enlarged drawing of Fig. 5.
Fig. 6 is the wiring schematic diagram of apparatus of the present invention.
Fig. 7 is the pipeline and runner schematic diagram of apparatus of the present invention.
Description of symbols:
1- computer；2- electrochemical workstation；The first storage cylinder of 3-；The second storage cylinder of 4-；The first air valve of 5-；The second gas of 6-
Valve；The first gas pipeline of 7-；The second gas pipeline of 8-；9- thermostat；10- reservoir；The first liquid-transport pipe-line of 11-；12- second is defeated
Liquid pipe road；13- third liquid-transport pipe-line；The 4th liquid-transport pipe-line of 14-；The 5th liquid-transport pipe-line of 15-；The first solvent valve of 16-；17- second
Solvent valve；18- third solvent valve；The 4th solvent valve of 19-；The 5th solvent valve of 20-；The first liquid reserve tank of 21-；The second liquid reserve tank of 22-；
23- third liquid reserve tank；The 4th liquid reserve tank of 24-；The 5th liquid reserve tank of 25-；26- pipeline；27- flowmeter；28-pH meter；29- temperature
Meter；30- sample slot；31- immersible pump；32- device under test；33- electrode；The first control line of 34-；The second control line of 35-；36-
One data line；The second data line of 37-；38- third control line；The 4th control line of 39-；The 5th control line of 40-；41- the 6th is controlled
Line；The 7th control line of 42-；The 8th control line of 43-；44- p-wire；45- third data line.
Specific embodiment
With reference to the accompanying drawing, technical solution of the present invention is further illustrated.
Referring to Fig. 1, Fig. 3, Fig. 4, medical magnesium alloy implant devices of the invention multifactor dynamic degradation performance evaluation in vitro
Device is by computer 1, electrochemical workstation 2, the first storage cylinder 3, the second storage cylinder 4, the first air valve 5, the second air valve 6, first
Gas pipeline 7, the second gas pipeline 8, thermostat 9, reservoir 10, the first liquid-transport pipe-line 11, the second liquid-transport pipe-line 12, third are defeated
Liquid pipe road 13, the 4th liquid-transport pipe-line 14, the 5th liquid-transport pipe-line 15, the first solvent valve 16, the second solvent valve 17, third solvent valve
18, the 4th solvent valve 19, the 5th solvent valve 20, the first liquid reserve tank 21, the second liquid reserve tank 22, third liquid reserve tank 23, the 4th liquid storage
Case 24, the 5th liquid reserve tank 25, pipeline 26, flowmeter 27, pH meter 28, thermometer 29, sample slot 30, immersible pump 31, device under test
32, electrode 33, the first control line 34, the second control line 35, the first data line 36, the second data line 37, third control line 38,
Four control lines 39, the 5th control line 40, the 6th control line 41, the 7th control line 42, the 8th control line 43, p-wire 44, third
Data line 45 forms.
Medical magnesium alloy implant devices of the invention multifactor dynamic degradation performance evaluation device in vitro, it is characterised in that:
It is characterized by: ground is equipped with computer 1, electrochemical workstation 2, the first storage cylinder 3, the second storage cylinder 4, thermostat 9, storage
Liquid bath 10, the first liquid reserve tank 21, the second liquid reserve tank 22, third liquid reserve tank 23, the 4th liquid reserve tank 24, the 5th liquid reserve tank 25, flow
Count 27, sample slot 30, immersible pump 31；Reservoir 10 is located in thermostat 9, and the water outlet of the immersible pump 31 of 10 bottom of reservoir is logical
Piping 26 connects flowmeter 27 and sample slot 30, and the water outlet of sample slot 30 connects reservoir 10 by pipeline, forms liquid
Circulation loop；Reservoir 10 is separately connected the first storage cylinder 3 and the second storage by the first gas pipeline 7 and the second gas pipeline 8
Gas cylinder 4, reservoir 10 pass through the first liquid-transport pipe-line 11, the second liquid-transport pipe-line 12, third liquid-transport pipe-line 13, the 4th liquid-transport pipe-line 14
The first liquid reserve tank 21, the second liquid reserve tank 22, third liquid reserve tank 23,24 and of the 4th liquid reserve tank are separately connected with the 5th liquid-transport pipe-line 15
5th liquid reserve tank 25；Computer 1 is separately connected the first air valve 5 and the second air valve by the first control line 34 and the second control line 35
6 control terminal, output and output quantity regulation to oxygen and carbon dioxide in the first storage cylinder 3 and the second storage cylinder 4；It calculates
Machine 1 passes through third control line 38, the 4th control line 39, the 5th control line 40, the 6th control line 41 and the 7th control line 42 difference
Connect with the control terminal of the 5th solvent valve 20, the 4th solvent valve 19, third solvent valve 18, the second solvent valve 17 and the first solvent valve 16
It connects, the output and output quantity regulation to protein, glucose, bacterium, sodium hydroxide and citric acid solution inside each liquid reserve tank；
Electrochemical workstation 2 by p-wire 44 with inside sample slot 30 electrode 33 and device under test 32 connect, it is electrochemical
Work station 2 is learned also to connect by third data line 45 with computer 1；
The control terminal of immersible pump 31 connects computer 1 by the 8th control line 43, and computer 1 regulates and controls liquid in pipeline 26
Flow velocity；
PH meter 28 and thermometer 29 are housed, the signal output end of pH meter 28 and thermometer 29 is respectively with first on sample slot 30
Data line 36 and the second data line 37 connect computer 1.
Computer 1 fixes on the ground, and the left side is separately connected first by the first control line 34 and the second control line 35
Air valve 5 and the second air valve 6 realize the regulation to the first air valve 5 and the second air valve 6；Pass through the first data line 36 and second above
Data line 37 is separately connected pH meter 28 and thermometer 29, realizes to pH meter 28 and the data real-time reception detected of thermometer 29；
The right is connect by third data line 45 with electrochemical workstation 2, realizes that the information surveyed and collected to electrochemical workstation 2 is real-time
It receives；It is connect below by the 8th control line 43 with immersible pump 31, realizes that the flow velocity for exporting simulated body fluid to immersible pump 31 regulates and controls；
Also by third control line 38, the 4th control line 39, the 5th control line 40, the 6th control line 41 and the 7th control line 42 respectively with
5th solvent valve 20, the 4th solvent valve 19, third solvent valve 18, the second solvent valve 17 and the connection of the first solvent valve 16, realization pair
The regulation of 5th solvent valve 20, the 4th solvent valve 19, third solvent valve 18, the second solvent valve 17 and the first solvent valve 16.
Electrochemical workstation 2 fixes on the ground, and the left side is connect by third data line 45 with computer 1, and the right passes through
P-wire 44 with inside sample slot 30 device under test 32 and electrode 33 connect.
First storage cylinder 3 and the second storage cylinder 4 fix on the ground, upper part the first air valve 5 of fixed connection and the respectively
Two air valves 6.
First air valve 5 and the second air valve 6 are the regulation component of the first storage cylinder 3 and the second storage cylinder 4 respectively, pass through first
Control line 34 and the second control line 35 are connect with computer 1, inside insert the first gas pipeline 7 and the second appendix respectively
Road 8.
First gas pipeline 7 and 8 left side of the second gas pipeline pass through the first air valve 5 respectively and the second air valve 6 has injected
Thermostat 9 and reservoir have been protruded by the through-hole on thermostat 9 and reservoir 10 in one storage cylinder 3 and the second storage cylinder 4, the right
10 inside.
Thermostat 9 fixes on the ground, internal storage reservoir 10, top and left part, which exist, is convenient for feed channel, solution
Multiple through-holes that pipeline passes through.
Reservoir 10 is fixed on inside thermostat 9, and top and left part are multiple in the presence of passing through convenient for feed channel, solution line
Through-hole, inside are placed immersible pump 31.
First liquid-transport pipe-line 11, the second liquid-transport pipe-line 12, third liquid-transport pipe-line 13, the 4th liquid-transport pipe-line 14 and the 5th infusion
The right of pipeline 15 passes through the 5th solvent valve 20, the 4th solvent valve 19, third solvent valve 18, the second solvent valve 17 and the first solution
The connection function of valve 16 inserts the first liquid reserve tank 21, the second liquid reserve tank 22, third liquid reserve tank 23,24 and of the 4th liquid reserve tank respectively
Thermostat 9 and reservoir 10 have been protruded by the through-hole on thermostat 9 and reservoir 10 in the inside of 5th liquid reserve tank 25, the left side
Inside.
First solvent valve 16, the second solvent valve 17, third solvent valve 18, the 4th solvent valve 19 and the 5th solvent valve 20 are
Five liquid reserve tanks 25, the 4th liquid reserve tank 24, third liquid reserve tank 23, the second liquid reserve tank 22 and the first liquid reserve tank 21 regulation component, lead to
Cross the 7th control line 42, the 6th control line 41, the 5th control line 40, the 4th control line 39 and third control line 38 and computer 1
Connection, inside insert the 5th liquid-transport pipe-line 15, the 4th liquid-transport pipe-line 14, third liquid-transport pipe-line 13, the second liquid-transport pipe-line 12
With the first liquid-transport pipe-line 11.
First liquid reserve tank 21, the second liquid reserve tank 22, third liquid reserve tank 23, the 4th liquid reserve tank 24 and the 5th liquid reserve tank 25 are fixed
On the ground, fixed there are the 5th solvent valve 20, the 4th solvent valve 19, third solvent valve 18, the second solvent valve 17 and the on top
One solvent valve 16.
Pipeline 26 is the transmission pipeline of simulated body fluid shuttling movement, on thermostat 9, reservoir 10 and sample slot 30
Through-hole is connected to flowmeter 27, sample slot 30, immersible pump 31.
Flowmeter 27 fixes on the ground, and the right and left has the hole being connected with pipeline 26.
PH meter 28 is fixed on sample slot 30, is connect by the first data line 36 with computer 1.
Thermometer 29 is fixed on sample slot 30, is connect by the second data line 37 with computer 1.
Sample slot 30 fixes on the ground, and the right and left has the through-hole passed through convenient for pipeline 26, and there are to be measured for inside
Device 32 and electrode 33, there are pH meters 28 and thermometer 29 on top.
Immersible pump 31 is fixed on inside reservoir 10, is passed through through-hole above and is connected to pipeline 26, passes through the 8th control line
43 are connected with computer 1.
Device under test 32 is the outer device under test of medical magnesium alloy implant, is fixed on inside sample slot 30, passes through p-wire
44 connect with electrochemical workstation 2.
Electrode 33 is fixed on inside sample slot 30, is connect by p-wire 44 with electrochemical workstation 2.
It referring to fig. 2, is the top view of apparatus of the present invention.
It is 30 cross-sectional view of thermostat 9, reservoir 10 and sample slot of apparatus of the present invention referring to Fig. 5.
It is the portion the A enlarged drawing of Fig. 5 referring to Fig. 5 a.
It is the wiring schematic diagram of apparatus of the present invention referring to Fig. 6.
It is the pipeline and runner schematic diagram of apparatus of the present invention referring to Fig. 7.
Content described in this specification embodiment is only enumerating to the way of realization of inventive concept, protection of the invention
Range should not be construed as being limited to the specific forms stated in the embodiments, and protection scope of the present invention is also and in art technology
Personnel conceive according to the present invention it is conceivable that equivalent technologies mean.
Claims (1)
1. medical magnesium alloy implant devices multifactor dynamic degradation performance evaluation device in vitro, it is characterised in that: including computer
(1), electrochemical workstation (2), the first storage cylinder (3), the second storage cylinder (4), thermostat (9), reservoir (10), the first liquid storage
Case (21), the second liquid reserve tank (22), third liquid reserve tank (23), the 4th liquid reserve tank (24), the 5th liquid reserve tank (25), flowmeter
(27), sample slot (30), immersible pump (31)；Reservoir (10) is located in thermostat (9), the immersible pump of reservoir (10) bottom
(31) water outlet passes through pipeline by pipeline (26) connection flowmeter (27) and sample slot (30), the water outlet of sample slot (30)
It connects reservoir (10), forms liquid circulation loop；Reservoir (10) passes through the first gas pipeline (7) and the second gas pipeline
(8) the first storage cylinder (3) and the second storage cylinder (4) are separately connected, reservoir (10) passes through the first liquid-transport pipe-line (11), second defeated
Liquid pipe road (12), third liquid-transport pipe-line (13), the 4th liquid-transport pipe-line (14) and the 5th liquid-transport pipe-line (15) are separately connected the first storage
Liquid case (21), the second liquid reserve tank (22), third liquid reserve tank (23), the 4th liquid reserve tank (24) and the 5th liquid reserve tank (25)；Computer
(1) control of the first air valve (5) and the second air valve (6) is separately connected by the first control line (34) and the second control line (35)
End, output and output quantity regulation to oxygen and carbon dioxide in the first storage cylinder (3) and the second storage cylinder (4)；Computer
(1) pass through third control line (38), the 4th control line (39), the 5th control line (40), the 6th control line (41) and the 7th control
Line (42) respectively with the 5th solvent valve (20), the 4th solvent valve (19), third solvent valve (18), the second solvent valve (17) and first
The control terminal of solvent valve (16) connects, to inside each liquid reserve tank protein, glucose, bacterium, sodium hydroxide and citric acid it is molten
The output of liquid and output quantity regulation；
Electrochemical workstation (2) is connected by p-wire (44) and sample slot (30) internal electrode (33) and device under test (32)
It connects, electrochemical workstation (2) is also connect by third data line (45) with computer (1)；
The control terminal of immersible pump (31) is regulated and controled in pipeline (26) by the 8th control line (43) connection computer (1), computer (1)
The flow velocity of liquid；
PH meter (28) and thermometer (29), the signal output end difference of pH meter (28) and thermometer (29) are housed on sample slot (30)
Computer 1 is connected with the first data line (36) and the second data line (37).
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| CN201910082013.0A CN109765282A (en) | 2019-01-28 | 2019-01-28 | Medical magnesium alloy implant devices multifactor dynamic degradation performance evaluation device in vitro |
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| CN201910082013.0A CN109765282A (en) | 2019-01-28 | 2019-01-28 | Medical magnesium alloy implant devices multifactor dynamic degradation performance evaluation device in vitro |
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