CN101158676B - Analysis method and device for evaluating blood and crucifixes oxygen carrying and oxygen releasing function thereof - Google Patents
Analysis method and device for evaluating blood and crucifixes oxygen carrying and oxygen releasing function thereof Download PDFInfo
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- CN101158676B CN101158676B CN2006100953987A CN200610095398A CN101158676B CN 101158676 B CN101158676 B CN 101158676B CN 2006100953987 A CN2006100953987 A CN 2006100953987A CN 200610095398 A CN200610095398 A CN 200610095398A CN 101158676 B CN101158676 B CN 101158676B
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Abstract
The invention relates to a method for testing an oxygen carrying and releasing function of the blood and the substitute of blood. The testing method comprises the following steps: establishing a simulated environment, calibrating the measuring electrode and analyzing the measuring result. The invention provides a device for testing the oxygen carrying and releasing function of the blood and the substitute of the blood. Due to the method and the device, and according to the establishment of simulated pressure chambers of the different partial pressures of oxygen, a model for replacing the outside oxygen with carbon dioxide is designed, and the replace mode for replacing the oxygen with carbon dioxide in the body of living creature is reappeared lively. And the invention can simulate different physiological conditions and special physiological environments, the research and analysis of oxygen carrying and releasing capacity of the blood and the substitute of blood can be completed in the conditions.
Description
Technical field
The present invention relates to a kind of mensuration blood and substitute thereof and take the method and the device of oxygen-oxygen release function.Be specifically related to both can be used as clinical analysis, also can be used as analytical approach and the device that research blood and substitute thereof are estimated its function of carrying oxygen.
Background technology
The analytical approach of existing mensuration blood oxygen saturation and device thereof can be divided into following several types, as blood gas analysis method and instrument, infrared absorption spectroscopy and the clinical monitor etc. of clinical practice substantially according to its test philosophy.
The blood gas analysis method is measured O mainly according to electrochemical principle respectively by special gas sensing electrode
2, CO
2With three data of pH, and extrapolate series of parameters.Though widespread use clinically, but still there is the difficult problem of successive reaction moment anoxic and oxygenate situation in time.Infrared absorption spectroscopy has been applied to the clinical physiological patient monitor for there not being wound pulse oxygen saturation measurements method, and its principle is different to the absorption spectrum of ruddiness and infrared light with reduced hemoglobin according to oxyhemoglobin in the blood, ratio calculated.The precondition that this method is measured is the artery blood flow that pulsation will be arranged, though can the continuous monitoring arterial oxygen saturation, but owing to be subjected to the complicacy of tested object (patient) sign, data are affected accurately and reliably, particularly for experiment in vitro, zoopery etc., this method is difficult to use in the evaluation of analysis blood oxygen saturation and takes oxygen-oxygen release function.
In blood substitute research, and in the practice of clinical monitoring, for the oxygen-saturated Study on Dynamics of blood, it is most important accurately and timely to gather data such as different blood oxygen saturations effectively.
The content of invention
One of purpose of the present invention provides a kind of method that is used to measure blood and surrogate solutions oxygen saturation partial pressure of oxygen thereof; Another object of the present invention provides a kind of device that is used to measure blood and surrogate solutions oxygen saturation partial pressure of oxygen thereof.
The technical scheme that realizes the present invention's first purpose and adopt is such, it is a kind of method that is used to measure blood and surrogate solutions oxygen saturation partial pressure of oxygen thereof, this method can simulate different physiological conditions, special physiological environment, finish under described environment the research and analysis of blood and multiple blood substitute oxygen carrying capacity, method may further comprise the steps:
1, sets up simulated environment: comprise nitrogen (N is set
2, oxygen (O
2) and carbon dioxide (CO
2) different sources of the gas, build-up pressure balance bunker, be delivered to pressure equilibrium storehouse in different ratios by gas piping by regulating each gas source and flow amount, simulate different partials pressure of oxygen; By different atmospheric pressure in vacuum pump and the valve member simulated pressure balance bunker, regulate the stagnation pressure of mixed gas in the pressure equilibrium storehouse;
2, the demarcation of potential electrode: under different partial pressure of oxygen conditions, measure the response of electrochemistry oxygen electrode, should satisfy linear relationship (referring to accompanying drawing 3) between partial pressure of oxygen in the pressure equilibrium storehouse and the oxygen saturation;
3, constant at atmospheric pressure, under the condition of the different proportion relations of simulation source of the gas, or it is constant at the proportion relation of source of the gas, simulate under the condition of different atmospheric pressures, in the pressure equilibrium storehouse, inject sample to be measured, under 35～38 ℃ of constant temperatures, by the partial pressure of oxygen and the oxygen saturation value of testing sample solution in the electrochemistry oxygen electrode measurement injection pressure balance bunker;
4, the analysis of test result: the relation curve of drawing testing sample oxygen saturation and partial pressure of oxygen under different partial; Under the constant condition of partial pressure of oxygen, the oxygen saturation value of measuring in per 2～10 minutes is drawn the oxygen saturation and the oxygen supply time relation curve of testing sample; By the relation curve of oxygen saturation and partial pressure of oxygen, and oxygen saturation and oxygen supply time relation curve, with the partial pressure of oxygen of testing sample when 50% oxygen saturation or/and required time value is taken the reference index of oxygen, oxygen release function as estimating testing sample.
In above-mentioned steps 1, the ratio of regulating each gas source and flow amount by flowmeter and valve member is to obtain required partial pressure of oxygen; The pressure equilibrium storehouse can be divided into balance bunker and measure the storehouse, finishes each gas source and flow amount of adjusting and be delivered to the pressure equilibrium storehouse in different ratios by gas piping in balance bunker, simulates different partials pressure of oxygen; Or, regulate the stagnation pressure of mixed gas in the pressure equilibrium storehouse by different atmospheric pressure in vacuum pump and the valve member simulated pressure balance bunker; The stagnation pressure of measuring the mixed gas in storehouse equates with the stagnation pressure of mixed gas in the balance bunker, regulates by the vacuum pump and the valve member that are connected with this storehouse if change.
Sampling unit sucks blood and waits for that the test sample product are to balance bunker in above-mentioned steps 3, by regulating flowmeter, the ratio of oxygen and carbon dioxide is increased gradually, blood and substitute thereof are earlier by increasing the oxygen saturation that partial pressure of oxygen improves blood, and then replacement of oxygen is come out by increasing partial pressure of carbon dioxide, after finishing exchange process, use replacement of oxygen again, the oxygen of blood is reached capacity.
Said method is by the different proportion of the flow of different sources of the gas, the change of simulation partial pressure of oxygen, simulate different physiological conditions, special physiological environment by vacuum pump regulating system stagnation pressure, as plateau, space flight and deep-sea, finish under described environment research and analysis to blood and multiple blood substitute oxygen carrying capacity.
Compare with existing analytical approach, the present invention designs external oxygen, carbon dioxide replacement model owing to pass through to set up the pressure storehouse of simulation different partial, and has reproduced oxygen, carbon dioxide replacement pattern in the biosome visually.Can simulate under different physiological conditions, the special physiological environment, finish under described environment research and analysis blood and multiple blood substitute oxygen carrying capacity.
Another object of the present invention is to realize by such technical scheme, it is a kind of device that is used to measure blood and blood substitute solution oxygen saturation or partial pressure of oxygen, it comprises blood oxygen exchange system and by the blood oxygen detecting and analysing system that oxygen electrode, time controller and data processor are formed, it is characterized in that blood oxygen exchange system comprises:
1), gas mixed cell: comprise source of the gas storage tank and pressure equilibrium bottle, wherein, storage tank comprises oxygen tank, nitrogen pot and carbon dioxide canister, described source of the gas storage tank is communicated with by the inlet end of tracheae with the pressure equilibrium bottle respectively, is connected with the pressure equilibrium bottle at storage tank to be provided with switch, rain glass, proportioning valve, flowmeter on the tracheae;
2), constitute sampling unit by sampling peristaltic pump and pipeline;
3), oxygen pressure warehouse receipt unit;
The adjustable side of the pressure equilibrium bottle in the described gas mixed cell is communicated with vacuum pump by tracheae, the gas outlet of pressure equilibrium bottle is communicated with by the sampling end of tracheae with oxygen pressure warehouse receipt unit, and the wriggling delivery side of pump is communicated with by the sampling end of pipeline with oxygen pressure warehouse receipt unit in the sampling unit.
The present invention designs external oxygen, carbon dioxide replacement model owing to set up the pressure storehouse that can simulate different partial, has reproduced oxygen, carbon dioxide replacement pattern, the oxygen that obtains and the correlation curve of carbon dioxide replacement in the biosome visually.For the function of carrying oxygen of evaluation of measuring blood and substitute thereof objectively provides may; But and the instant analysis blood oxygenation, provide and take the oxygen kinetic curve, can estimate the dynamics of various blood substitutes effectively.
Description of drawings
Description of drawings of the present invention is as follows:
Fig. 1 system and device structural drawing of the present invention;
The response curve of the oxygen electrode that Fig. 2 the present invention measures under different partial;
The oxygen saturation that Fig. 3 measures for the present invention is to the response curve of partial pressure of oxygen;
Fig. 4 is the response curve of system and device oxygen saturation of the present invention to the oxygen supply time;
Fig. 5 is the displacement curve of system and device oxygen of the present invention and carbon dioxide.
Fig. 6 artificial red blood cells and different blood sample reach oxygen saturation SatO2
50The required time.
Among the figure: 1. oxygen electrode; 2. time controller; 3. data processor; 4. pressure equilibrium bottle; 5. oxygen tank; 6. nitrogen pot; 7. carbon dioxide canister; 8. tracheae; 9. inlet end; 10. switch; 11. rain glass; 12. proportioning valve; 13. flowmeter; 14. sampling peristaltic pump; 15. pipeline; 16. oxygen pressure warehouse receipt unit; 17. gas outlet; 18. sampling end; 19. cross flow export; 20. stock layout peristaltic pump; 21. adjustable side; 22. vacuum pump.
Embodiment
The invention will be further described below in conjunction with drawings and Examples:
In conjunction with Fig. 1 as can be known, during blood oxygen exchange system of the present invention comprises
1), the gas mixed cell comprises source of the gas storage tank and pressure equilibrium bottle 4, wherein, storage tank comprises oxygen tank 5, nitrogen pot 6 and carbon dioxide canister 7, three source of the gas storage tanks are communicated with by the inlet end of tracheae with pressure equilibrium bottle 4 respectively, are connected with pressure equilibrium bottle 4 at storage tank to be provided with switch 10, rain glass 11, proportioning valve 12, flowmeter 13 on the tracheae 8;
2), constitute sampling unit by sampling peristaltic pump 14 and pipeline 15;
3), oxygen pressure warehouse receipt unit 16;
The adjustable side 21 of the pressure equilibrium bottle 4 in the described gas mixed cell is communicated with vacuum pump 22 by tracheae 8, the gas outlet 17 of pressure equilibrium bottle 4 is communicated with the sampling end 18 of oxygen pressure warehouse receipt unit 16 by tracheae 8, and the outlet of sampling peristaltic pump 14 is communicated with the sampling end 18 of oxygen pressure warehouse receipt unit 16 by pipeline 15 in the sampling unit.
Principle of the present invention and function: elder generation is with the gas tank of different sources of the gas, by tracheae 8, flowmeter 13, switch 10, proportioning valve 12 and rain glass separately 11 enter into pressure equilibrium bottle 4, pressure equilibrium bottle 4 makes up oxygen pressure warehouse receipt unit 16 by design cycle again, by adjusting different partial and system's stagnation pressure, form the oxygen pressure warehouse receipt unit 16 of specific partial pressure of oxygen, samples such as sampling unit suction blood are to oxygen pressure warehouse receipt unit 16, by flowmeter 13, the ratio of oxygen and carbon dioxide is increased gradually, blood and substitute thereof are earlier by increasing the oxygen saturation that partial pressure of oxygen improves blood, and then replacement of oxygen is come out by increasing partial pressure of carbon dioxide, after finishing exchange process, use replacement of oxygen again, the oxygen of blood is reached capacity, to data processor 3, measure the partial pressure of oxygen and the oxygen saturation of blood and substitute thereof by oxygen electrode 1 and time controller 2 transmission oxygen current signals and oxygenation time signal immediately; Data processor again computational analysis provide partial pressure of oxygen and oxygen saturation correlation curve, partial pressure of oxygen and oxygenation time take the oxygen kinetic curve.
Pressure warehouse receipt unit in the described blood oxygen exchange system is the core, and the function of carrying oxygen of evaluating and measuring blood and various blood substitutes all must be measured the saturation degree of oxygen under different partials pressure of oxygen, different oxygen therapy time conditions; Draw partial pressure of oxygen PO2 and oxygen saturation SatO2 correlation curve then and take the oxygen kinetic curve referring to Fig. 3 or Fig. 5, oxygen saturation SatO2 and oxygen supply time tO2.Therefore, the characteristics of this oxygen pressure warehouse receipt unit are exactly the different partial condition of setting up under the specific system stagnation pressure.Under the system stagnation pressure keeps constant condition, in conjunction with shown in Figure 3, regulate and control the number percent of all gases with the flowmeter 13 of regulating various sources of the gas, obtain the different dividing potential drop of all gases.The function of this system is: by regulating flowmeter 13, the ratio of oxygen and carbon dioxide is increased gradually, blood and substitute thereof are earlier by increasing the oxygen saturation that partial pressure of oxygen improves blood; And then replacement of oxygen is come out by increasing partial pressure of carbon dioxide; After finishing exchange process, use replacement of oxygen again, the oxygen of blood is reached capacity, referring to the oxygen of Fig. 6 and the curve of carbon dioxide replacement.The external oxygen of this blood and substitute thereof, carbon dioxide replacement system have reproduced oxygen, carbon dioxide replacement pattern in the biosome visually, for the function of carrying oxygen of evaluation of measuring blood and substitute thereof objectively provides may.Under constant partial pressure of oxygen condition, blood and substitute oxygen therapy thereof are given in timing, and the trend that oxygen saturation increases with oxygen supply time in monitoring blood and the blood substitute is observed time tsat50% required when reaching 50% oxygen saturation.Be partial pressure of oxygen numerical value and the corresponding relation of record and oxygenation time that data processor collection process high input impedance operational amplifier and signal processing unit are sent into, utilize the sweep scatter diagram to draw formula and take the oxygen kinetic curve, so that observe the situation of change of oxygen saturation SatO2 intuitively with oxygenation time tO2 increase with what this corresponding relation was modeled as oxygen saturation SatO2 and oxygenation time tO2.The vacuum pump 22 of this system is to be used for the regulating system stagnation pressure, to simulate different physiological conditions, special physiological environment, as plateau, space flight and deep-sea, finishes under described environment the research and analysis to blood and multiple blood substitute oxygen carrying capacity.
Oxygen electrode is the key component of analytic system in the described blood oxygen test macro, it adopts existing Clarke (clark) electrochemistry oxygen electrode: with the platinum wire is that negative electrode is an oxygen electrode, with silver-oxidation silver strip is anode, outer cover ptfe plastic sleeve pipe and plastic sheeting.Between electrode and sleeve pipe, fill the Klorvess Liquid of 0.5 equivalent.
Under the polarizing voltage effect, dissolved molecular oxygen is reduced.
And be formed centrally diffusion layer in the negative electrode platinum wire being, and this dissufion current becomes linear dependence with partial pressure of oxygen in the testing sample, and in conjunction with shown in Figure 3, oxygen electrode is issued to the correlation curve of different oxygen saturations in different partials pressure of oxygen.
The oxygen current signal that electrochemical reaction produces on the platinum wire electrode, amplify and signal processing unit through high input impedance operational amplifier, enter data processor, the function of data processor is to utilize computer program to gather input signal and functional simulation, simultaneously on computer screen designation number, show that partial pressure of oxygen PO2 and oxygen saturation SatO2 correlation curve take the oxygen kinetic curve referring to Fig. 4 referring to Fig. 5, oxygen saturation SatO2 and oxygenation time tO2.The signal of computer program to gathering, and the corresponding relation with the oxygenation time of keeping a record, utilize the sweep scatter diagram to draw formula and take the oxygen kinetic curve, so that observe the situation of change of oxygen saturation SatO2 intuitively with oxygenation time tO2 increase with what this corresponding relation was modeled as oxygen saturation SatO2 and oxygenation time tO2.
In conjunction with Fig. 1 as can be known, for the ease of stock layout, the bottom of oxygen pressure warehouse receipt unit 16 was provided with flow export 19.
In conjunction with Fig. 1 as can be known, the described flow export 19 of crossing communicates with stock layout peristaltic pump 20 by pipeline 15.Be like this for more easily with the emptying of waste liquid sample, and clean, so that test next time.
To newly prepare artificial red blood cells's blood substitute, be drawn into oxygen pressure warehouse receipt unit by sampling unit, pass through flowmeter, the ratio of oxygen and carbon dioxide is increased gradually, artificial red blood cells's blood substitute improves blood oxygen saturation by increasing partial pressure of oxygen earlier, and then replacement of oxygen is come out by increasing partial pressure of carbon dioxide, after finishing exchange process, use replacement of oxygen again, the oxygen of artificial red blood cells's blood substitute is reached capacity, to data processor, measure the partial pressure of oxygen and the oxygen saturation of blood and substitute thereof by oxygen electrode and time controller transmission oxygen current signal and oxygenation time signal immediately; Data processor again computational analysis provide partial pressure of oxygen and oxygen saturation correlation curve, partial pressure of oxygen and oxygenation time take the oxygen kinetic curve.
With people's whole blood of newly gathering, regulating blood hematocrit Hct with physiological saline is 20%, 6%; The whole blood hematocrit is about 45%.The people's whole blood that to adjust behind the hematocrit by sampling unit is drawn into oxygen pressure warehouse receipt unit, pass through flowmeter, the ratio of oxygen and carbon dioxide is increased gradually, blood sample improves blood oxygen saturation by increasing partial pressure of oxygen earlier, and then replacement of oxygen is come out by increasing partial pressure of carbon dioxide, after finishing exchange process, use replacement of oxygen again, the oxygen of blood sample is reached capacity, to data processor, measure the partial pressure of oxygen and the oxygen saturation of blood and substitute thereof by oxygen electrode and time controller transmission oxygen current signal and oxygenation time signal immediately; Data processor again computational analysis provide partial pressure of oxygen and oxygen saturation correlation curve, partial pressure of oxygen and oxygenation time take the oxygen kinetic curve.
With the rabbit whole blood of newly gathering, regulating blood hematocrit Hct with physiological saline is 20%, 6%; The whole blood hematocrit is about 45%.The rabbit whole blood that to adjust behind the hematocrit by sampling unit is drawn into oxygen pressure warehouse receipt unit, pass through flowmeter, the ratio of oxygen and carbon dioxide is increased gradually, blood sample improves blood oxygen saturation by increasing partial pressure of oxygen earlier, and then replacement of oxygen is come out by increasing partial pressure of carbon dioxide, after finishing exchange process, use replacement of oxygen again, the oxygen of rabbit blood sample is reached capacity, to data processor, measure the partial pressure of oxygen and the oxygen saturation of blood and substitute thereof by oxygen electrode and time controller transmission oxygen current signal and oxygenation time signal immediately; Data processor again computational analysis provide partial pressure of oxygen and oxygen saturation correlation curve, partial pressure of oxygen and oxygenation time take the oxygen kinetic curve.
By the enforcement of the various embodiments described above, can analyze various sample solutions and reach oxygen saturation SatO2
50The needed time, thus draw each sample under the same oxygen partial pressure conditions, recover the difference of oxygen carrying capacity, see Fig. 6.
The present invention designs external oxygen, carbon dioxide replacement model owing to set up the pressure storehouse that can simulate different partial, has reproduced oxygen, carbon dioxide replacement pattern, the oxygen that obtains and the correlation curve of carbon dioxide replacement in the biosome visually.For the function of carrying oxygen of evaluation of measuring blood and substitute thereof objectively provides may; But and the instant analysis blood oxygenation, provide and take the oxygen kinetic curve, can estimate the dynamics of various blood substitutes effectively.
Claims (3)
1. measure the method that blood and substitute thereof are taken oxygen, oxygen release function for one kind, it is characterized in that: method may further comprise the steps:
1), sets up simulated environment: comprise different sources of the gas, build-up pressure balance bunker that nitrogen, oxygen and carbon dioxide are set, be delivered to the pressure equilibrium storehouse in different ratios by gas piping, simulate different partials pressure of oxygen by regulating each gas source and flow amount; By different atmospheric pressure in vacuum pump and the valve member simulated pressure balance bunker, in order to regulate the stagnation pressure of mixed gas in the pressure equilibrium storehouse;
2), the demarcation of potential electrode: under different partial pressure of oxygen conditions, measure the response of electrochemistry oxygen electrode, should satisfy linear relationship between partial pressure of oxygen in the pressure equilibrium storehouse that records and the oxygen saturation;
3), constant at atmospheric pressure, under the condition of the different proportion relations of simulation source of the gas, or it is constant at the proportion relation of source of the gas, simulate under the condition of different atmospheric pressures, in the pressure equilibrium storehouse, inject sample to be measured, and 35 ℃～38 ℃ constant temperature, by the partial pressure of oxygen and the oxygen saturation value of testing sample solution in the electrochemistry oxygen electrode measurement injection pressure balance bunker;
4), the analysis of test result: the relation curve of drawing testing sample oxygen saturation and partial pressure of oxygen under different partial; Under the constant condition of partial pressure of oxygen, the oxygen saturation value of measuring in per 2～10 minutes is drawn the oxygen saturation and the oxygen supply time relation curve of testing sample; By the relation curve of oxygen saturation and partial pressure of oxygen, and oxygen saturation and oxygen supply time relation curve, with the partial pressure of oxygen of testing sample when 50% oxygen saturation or/and required time value is taken the reference index of oxygen, oxygen release function as estimating testing sample.
2. according to the described a kind of method that blood and substitute thereof are taken oxygen, oxygen release function of measuring of claim, it is characterized in that: in the described step 1), the ratio of regulating each gas source and flow amount by flowmeter and valve member is to obtain required partial pressure of oxygen; The pressure equilibrium storehouse is divided into balance bunker and measures the storehouse, finishes each gas source and flow amount of adjusting and be delivered to the pressure equilibrium storehouse in different ratios by gas piping in balance bunker, simulates different partials pressure of oxygen; By different atmospheric pressure in vacuum pump and the valve member simulated pressure balance bunker, regulate the stagnation pressure of mixed gas in the pressure equilibrium storehouse; The stagnation pressure of measuring the mixed gas in storehouse equates, regulates by the vacuum pump and the valve member that are connected with this pressure equilibrium storehouse if change.
3. measure the device that blood and substitute thereof are taken oxygen, oxygen release function for one kind, it comprises blood oxygen exchange system and divides a folding system by the blood oxygen test that oxygen electrode, time controller and data processor are formed that it is characterized in that: blood oxygen exchange system comprises:
1), gas mixed cell: comprise source of the gas storage tank and pressure equilibrium bottle, wherein, storage tank comprises oxygen tank, nitrogen pot and carbon dioxide tank, described source of the gas storage tank is communicated with by the inlet end of tracheae with the pressure equilibrium bottle respectively, is connected with the pressure equilibrium bottle at storage tank to be provided with switch, rain glass, proportioning valve, flowmeter on the tracheae;
2), constitute sampling unit by sampling peristaltic pump and pipeline;
3), oxygen pressure warehouse receipt unit;
The adjustable side of the pressure equilibrium bottle in the described gas mixed cell is communicated with vacuum pump by tracheae, the outlet side of pressure equilibrium bottle is communicated with by the sampling end of tracheae with oxygen pressure warehouse receipt unit, and sampling unit wriggling delivery side of pump is communicated with by the sampling end of pipeline with oxygen pressure warehouse receipt unit.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103405235B (en) * | 2013-08-09 | 2016-03-02 | 兰州大学 | Multi-mode temperature control dynamic test device for blood oxygen differential pressure |
| CN107228947B (en) * | 2017-07-04 | 2019-01-01 | 中国人民解放军军事医学科学院野战输血研究所 | The relative evaluation device and relative evaluation method of carrier of oxygen carrying-releasing oxygen ability |
| CN109949677B (en) * | 2019-03-26 | 2021-07-13 | 长春大学 | Vascular field simulation device |
| CN110926897A (en) * | 2019-12-06 | 2020-03-27 | 北京市医疗器械检验所 | Device and method for adjusting oxygen partial pressure in human blood sample |
| CN117269284B (en) * | 2023-11-22 | 2024-02-27 | 中国人民解放军军事科学院军事医学研究院 | Oxygen carrying-releasing capacity relative evaluation device |
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