CN109949677B - Vascular field simulation device - Google Patents
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- CN109949677B CN109949677B CN201910232527.XA CN201910232527A CN109949677B CN 109949677 B CN109949677 B CN 109949677B CN 201910232527 A CN201910232527 A CN 201910232527A CN 109949677 B CN109949677 B CN 109949677B
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Abstract
The application discloses a vascular field simulation device, which comprises a controller, a driving mechanism, a blood simulation device, a simulation organ and an oxygen introducing device; the blood simulation device is used for simulating the environment of blood with preset temperature; the simulation organ is used for representing a specific organ of a human body, and a preset number of simulation channels are arranged in the simulation organ; the controller is used for controlling the on-off of the oxygen introducing device so as to control the oxygen amount introduced into the blood simulating device by the oxygen introducing device and controlling the movement of the driving mechanism; the driving mechanism is used for driving blood combined with oxygen in the blood simulation device to be input into the simulation channel during movement so as to measure the blood oxygen saturation of the blood through a measuring instrument arranged in the simulation organ, wherein the driving mechanism generates periodically-changed driving force during movement, and the change of the driving force is consistent with the curve of the arterial blood of the human body. The application provides a more reliable and real simulation environment, and facilitates the test and calibration of the measuring instrument.
Description
Technical Field
The application relates to the technical field of biomedicine, in particular to a vascular field simulation device.
Background
Real-time monitoring of arterial blood oxygen saturation is important in clinical care. The traditional oxyhemoglobin saturation measuring method is to firstly take blood from a human body, then carry out electrochemical analysis by using a blood gas analyzer and calculate the oxyhemoglobin saturation. This method is cumbersome, causes secondary damage to the patient, and does not allow for continuous monitoring. Therefore, a measuring instrument capable of real-time, continuous and noninvasive blood oxygen saturation has been widely researched and focused.
Before the measuring instrument is put into use, the testing and calibration are needed, the test by human bodies or animals is troublesome, the cost is high, and a simulation device is generally adopted to provide a required simulation environment. The simulation environment provided by the existing simulation device only simply considers the blood temperature, the simulated blood vessel blood pressure is a constant value, and the blood pressure of the human blood vessel continuously changes in a periodic fluctuation state, as shown in fig. 1, it can be seen that the simulation environment provided by the existing simulation device has a large deviation from the real environment of the human blood vessel, which brings adverse effects to the test and calibration of the measuring instrument.
Therefore, how to provide a solution to the above technical problems is a problem that needs to be solved by those skilled in the art.
Disclosure of Invention
The purpose of this application is to provide a vascular field analogue means, provides more reliable and real simulation environment, just can carry out the test and the demarcation of measuring apparatu under the condition with the help of human body or animal, makes things convenient for the test and the demarcation of measuring apparatu.
In order to solve the technical problem, the application provides a vascular field simulation device, which comprises a controller, a driving mechanism, a blood simulation device, a simulation organ and an oxygen introducing device;
the blood simulation device is used for simulating the environment of blood with preset temperature;
the simulation organ is used for representing a specific organ of a human body, and a preset number of simulation channels are arranged in the simulation organ;
the controller is used for controlling the switch of the oxygen introducing device so as to control the oxygen amount introduced into the blood simulating device by the oxygen introducing device and controlling the driving mechanism to move;
the driving mechanism is used for driving blood combined with oxygen in the blood simulation device to be input into the simulation channel during movement so as to measure the blood oxygen saturation of the blood through a measuring instrument arranged in the simulation organ, wherein the driving mechanism generates a periodically-changed driving force during movement, and the change of the driving force is consistent with the curve of the arterial blood of the human body.
Preferably, the blood simulator comprises:
a blood tank for containing blood; and the temperature control module is used for maintaining the temperature of the blood in the blood cylinder at a preset temperature.
Preferably, the temperature control module comprises a temperature sensor.
Preferably, the simulated organ is a simulated bladder.
Preferably, the predetermined number is an integer greater than 1.
Preferably, the diameters of the plurality of emulation tunnels are not equal.
Preferably, the controller is a Programmable Logic Controller (PLC).
Preferably, the drive mechanism is a cam piston drive mechanism.
Preferably, the oxygen introducing device is an oxygen cylinder.
Preferably, the simulated organ is a silica gel simulated organ.
The application provides a vascular field simulation device, which comprises a controller, a driving mechanism, a blood simulation device, a simulation organ and an oxygen introducing device; the blood simulation device is used for simulating the environment of blood with preset temperature; the simulation organ is used for representing a specific organ of a human body, and a preset number of simulation channels are arranged in the simulation organ; the controller is used for controlling the on-off of the oxygen introducing device so as to control the oxygen amount introduced into the blood simulating device by the oxygen introducing device and controlling the movement of the driving mechanism; the driving mechanism is used for driving blood combined with oxygen in the blood simulation device to be input into the simulation channel during movement so as to measure the blood oxygen saturation of the blood through a measuring instrument arranged in the simulation organ, wherein the driving mechanism generates periodically-changed driving force during movement, and the change of the driving force is consistent with the curve of the arterial blood of the human body.
The blood vessel field simulation device utilizes the driving mechanism to provide the blood simulation device with the change driving force which is consistent with the change of the blood curve of the human artery, so that the blood pressure of the blood entering the simulation channel in the simulation organ is consistent with the change condition of the blood pressure in the actual environment of the human body, a more reliable and real simulation environment is provided, the measurement instrument can be tested and calibrated under the condition without the help of the human body or the animal, and the measurement instrument is convenient to test and calibrate.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the prior art and the embodiments are briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a schematic diagram of a blood pressure curve of an arterial blood vessel of a human body according to the present application;
fig. 2 is a schematic structural diagram of a vascular field simulation apparatus provided in the present application;
fig. 3 is a schematic structural diagram of another vascular field simulation apparatus provided in the present application.
Detailed Description
The core of the application is to provide a vascular field simulation device, which provides a more reliable and real simulation environment, can test and calibrate the measuring instrument without the help of human bodies or animals, and facilitates the test and calibration of the measuring instrument.
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Referring to fig. 2 and 3, fig. 2 is a schematic structural diagram of a blood vessel field simulation apparatus provided in the present application, and fig. 3 is a schematic structural diagram of another blood vessel field simulation apparatus provided in the present application, including a controller 1, a driving mechanism 2, a blood simulation apparatus 3, a simulated organ 4, and an oxygen ventilation apparatus 5;
the blood simulation device 3 is used for simulating the environment of blood with preset temperature;
the simulation organ 4 is used for representing a specific organ of a human body, and a preset number of simulation channels are arranged in the simulation organ;
the controller 1 is used for controlling the on-off of the oxygen introducing device 5 so as to control the oxygen amount introduced into the blood simulation device 3 by the oxygen introducing device 5 and also used for controlling the movement of the driving mechanism 2;
the driving mechanism 2 is used for driving blood combined with oxygen in the blood simulation device 3 to be input into the simulation channel during movement so as to measure the blood oxygen saturation of the blood through a measuring instrument arranged in the simulation organ 4, wherein the driving mechanism 2 generates periodically-changed driving force during movement, and the change of the driving force is consistent with the curve of the human artery blood.
Specifically, in order to solve the problems in the prior art, the present application provides a blood vessel field simulation apparatus, which includes a controller 1, a driving mechanism 2, a blood simulation apparatus 3, a simulation organ 4, and an oxygen supply apparatus 5, wherein the controller 1 may be an electric controller, and in a case where the blood vessel field simulation apparatus is powered on, the controller 1 may rotate the driving mechanism 2, and when the driving mechanism 2 rotates, a driving force is generated on the blood simulation apparatus 3, and blood at a preset temperature in the blood simulation apparatus 3, such as 36 ℃, contains hemoglobin capable of combining with oxygen. Under the driving force, the blood in the blood simulator 3 is inputted into the simulation channel of the simulated organ 4, so that the meter in the simulated organ 4 measures the blood oxygen saturation of the blood.
It should be noted that the measuring instrument can be a sensor based on the blood volume principle and the spectrophotometric principle, and has the advantages of real-time performance, non-invasive performance and continuity. Specifically, the measurement principle of the non-invasive arterial blood oxygen saturation comprises two parts of a blood volume principle and a spectrophotometry measurement principle. Spectrophotometric measurements are based on the difference in the absorption characteristics of oxygenated hemoglobin (Sp02) and reduced hemoglobin (Hb) to yield a blood oxygen saturation value. The reduced hemoglobin has less absorption of red light with the wavelength of 660nm and more absorption of infrared light with the wavelength of 940 nm; while oxyhemoglobin (Sp02) absorbs less red light at a wavelength of 660nm and more infrared light at a wavelength of 940 nm. In addition, the amount of light absorbed by other components in the tissue, such as venous blood, bones, skin, muscles, and the like, is constant, but the absorption of light by oxygenated hemoglobin and reduced hemoglobin in blood varies with the periodic variation of the pulse wave. When the heart contracts, the peripheral blood volume is the largest, the light absorption amount of blood is the largest, and the detected light energy is the smallest; the opposite is true at diastole. The change of the blood absorption reflects the change of the blood volume, so that the change of the illumination intensity can be obtained only by the blood volume of the artery, which is the blood volume principle. The two characteristics provide a theoretical basis for the measurement of the blood oxygen saturation. According to the different collection modes of the sensors, the sensors can be divided into a transmission type sensor and a reflection type sensor, and the blood vessel field simulation device is suitable for the two sensors.
Of course, the measuring instrument may be other than the transmission type and the reflection type, and the present application is not limited thereto.
The application provides a vascular field simulation device, which comprises a controller, a driving mechanism, a blood simulation device, a simulation organ and an oxygen introducing device; the blood simulation device is used for simulating the environment of blood with preset temperature; the simulation organ is used for representing a specific organ of a human body, and a preset number of simulation channels are arranged in the simulation organ; the controller is used for controlling the on-off of the oxygen introducing device so as to control the oxygen amount introduced into the blood simulating device by the oxygen introducing device and controlling the movement of the driving mechanism; the driving mechanism is used for driving blood combined with oxygen in the blood simulation device to be input into the simulation channel during movement so as to measure the blood oxygen saturation of the blood through a measuring instrument arranged in the simulation organ, wherein the driving mechanism generates periodically-changed driving force during movement, and the change of the driving force is consistent with the curve of the arterial blood of the human body.
The blood vessel field simulation device utilizes the driving mechanism to provide the blood simulation device with the change driving force which is consistent with the change of the blood curve of the human artery, so that the blood pressure of the blood entering the simulation channel in the simulation organ is consistent with the change condition of the blood pressure in the actual environment of the human body, a more reliable and real simulation environment is provided, the measurement instrument can be tested and calibrated under the condition without the help of the human body or the animal, and the measurement instrument is convenient to test and calibrate.
On the basis of the above-described embodiment:
as a preferred embodiment, the blood simulator 3 comprises:
a blood tank for containing blood; and the temperature control module is used for maintaining the temperature of the blood in the blood cylinder at a preset temperature.
Specifically, in order to simulate the environment in which human blood is located, the blood simulation apparatus 3 of the present application may include a blood tank and a temperature control module, wherein the temperature control module is connected with the controller 1, and when the temperature of blood in the blood tank is lower than a preset temperature, under the control of the controller 1, the temperature control module heats the blood tank until the temperature of blood in the blood tank reaches the preset temperature.
The blood simulator 3 may have other configurations than the above-described configuration, and the present application is not limited to this.
As a preferred embodiment, the temperature control module comprises a temperature sensor.
Specifically, blood analogue means 3 is in this in-process of maintaining the temperature of blood at preset temperature, and temperature control module can real-time detection blood's in the blood jar temperature, and in order to facilitate the detection, this application can adopt the temperature sensor who has the temperature detection function, for example can be DHT11 digital temperature sensor, and it has the response fast, the interference killing feature is strong, data accuracy is high.
Of course, the above functions may be implemented by other methods besides the above methods, and the present application is not limited thereto.
As a preferred embodiment, the simulated organ 4 is a simulated bladder.
Specifically, the simulated organ 4 of the present application may be a simulated bladder, the simulated organ 4 may be different, the simulated environment may be different, the blood pressure change may be different, and the driving mechanism 2 may be changed accordingly. When emulation organ 4 is emulation bladder, this application provides a vascular field simulation environment for can carry out the precision of the oxyhemoglobin saturation measuring apparatu of oxyhemoglobin saturation data acquisition inside human bladder or test, just can carry out the human clinical trial of next step after oxyhemoglobin saturation measuring apparatu passes through test and precision calibration.
Of course, the simulated organ 4 may be other than the simulated bladder, and the present application is not limited thereto.
As a preferred embodiment, the predetermined number is an integer greater than 1.
Specifically, in order to provide a simulation environment closer to the real organs of the human body, the simulation channels of the application are multiple. Because the blood vessels in the human organs are many, a plurality of blood vessels form a blood vessel field instead of a single blood vessel, if only one simulation channel is adopted to simulate the blood vessels, the difference with the actual environment is large, therefore, in order to enable the environment of testing and calibration to be closer to the real human environment, the number of the simulation channels is kept consistent with the number of the blood vessels in the human organs as much as possible.
As a preferred embodiment, the diameters of the plurality of dummy channels are not equal.
Specifically, in order to further approach the situation of the layout of blood vessels in a real organ of a human body, the diameters of the simulation channels are unequal, and it is conceivable that the thicknesses of the blood vessels in the organ of the human body are different, so that the simulation channels can be set to different diameters according to the actual situation of the organ of the human body, and the test and calibration results of the measuring instrument are more accurate.
It should be noted that, in addition to considering the diameter and the number, the simulated organ 4 may be modified from other aspects to approximate the actual human environment, such as the material, and the application is not limited thereto.
As a preferred embodiment, the Controller 1 is a PLC (Programmable Logic Controller).
Specifically, for the convenience of control, controller 1 of this application can be PLC, compares with other controllers 1, and PLC has with low costs, and the reliability is high, advantages such as interference killing feature is strong.
In addition, the controller 1 may be other than the PLC, and the present application is not particularly limited thereto.
As a preferred embodiment, the drive mechanism 2 is a cam-type piston drive mechanism.
Specifically, in order to provide a simulation environment closer to the real environment of a human organ and ensure the accuracy of the measurement and calibration of the measuring instrument, the driving mechanism 2 of the present application may be a cam-type piston driving mechanism, in order to enable the cam-type piston driving mechanism to provide a driving force consistent with the change of the blood curve of the human artery in fig. 1, the cam profile of the cam-type piston driving mechanism of the present application may be consistent with the blood curve of the human artery in fig. 1, so that the driving force which periodically changes can be generated to the blood cylinder along with the rotation of the cam-type piston driving mechanism, for example, the driving force decreases gradually after the driving force increases to the maximum in the systolic period and the driving force decreases in the diastolic period, and thus the blood pressure in the blood cylinder can also be consistent with the change of the blood pressure in the human organ, it can be seen that the blood vessel field simulation device of the present application can simulate the periodically fluctuating state of the blood pressure, more approximate to the pulse fluctuation phenomenon of the blood pressure in the blood of a real human body.
The drive mechanism 2 may be other than the cam-type piston drive mechanism, and the present application is not limited to this.
As a preferred embodiment, the oxygen introducing device 5 is an oxygen cylinder.
Specifically, in consideration of the fact that different blood sample concentrations in blood, i.e., different blood oxygen saturation levels, are caused by different oxygen carrying capacities of different human bodies, the blood simulation apparatus 3 needs to provide blood with different blood sample concentrations in order to simulate the environment of the same organ of different human bodies and facilitate the testing and calibration of the measuring instrument. This application lets in the oxygen volume in the blood analogue means 3 through changing logical oxygen device 5 for blood is also different in the combination degree of oxygen, thereby provides the blood of different blood oxygen concentration.
In consideration of convenience, the oxygen introducing device 5 of the present application may be an oxygen cylinder, as shown in fig. 3, the oxygen cylinder is generally provided with a switch, and the controller 1 can control the amount of the introduced oxygen by controlling the time length of the switch, which is simple and convenient to implement.
Of course, the oxygen introducing device 5 may be an oxygen cylinder or others, and the present application is not limited thereto.
As a preferred embodiment, the simulated organ 4 is a silicone simulated organ.
Specifically, in order to provide a simulation environment closer to the real environment of the human organ, the simulation organ 4 may be a closed simulation organ 4 made of silica gel, and when the closed simulation organ 4 is manufactured, simulation channels similar to different blood vessels in the human organ with different thicknesses may be processed in the silica gel. The closed simulation organ 4 provides a blood vessel field environment for testing and calibrating for the measuring instrument.
The material of the simulated organ 4 may be silica gel, or may be other materials, and the present application is not limited thereto.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The method disclosed by the embodiment corresponds to the system disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the system part for description.
It is further noted that, in the present specification, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising a" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. A vascular field simulation device is characterized by comprising a controller, a driving mechanism, a blood simulation device, a simulation organ and an oxygen introducing device;
the blood simulation device is used for simulating the environment of blood with preset temperature;
the simulation organ is used for representing a specific organ of a human body, and a preset number of simulation channels are arranged in the simulation organ;
the controller is used for controlling the switch of the oxygen introducing device so as to control the oxygen amount introduced into the blood simulating device by the oxygen introducing device and controlling the driving mechanism to move;
the driving mechanism is used for driving blood combined with oxygen in the blood simulation device to be input into the simulation channel during movement so as to measure the blood oxygen saturation of the blood through a measuring instrument arranged in the simulation organ, wherein the driving mechanism generates a periodically-changed driving force during movement, and the change of the driving force is consistent with the curve of the arterial blood of the human body;
the predetermined number is an integer greater than 1;
the diameters of the plurality of simulation channels are not equal.
2. The vascular field simulation device of claim 1, wherein the blood simulation device comprises:
a blood tank for containing blood; and the temperature control module is used for maintaining the temperature of the blood in the blood cylinder at a preset temperature.
3. The vascular field simulation device of claim 2, wherein the temperature control module comprises a temperature sensor.
4. The vascular field simulation device of claim 1, wherein the simulated organ is a simulated bladder.
5. The vascular field simulation device of claim 1, wherein the controller is a Programmable Logic Controller (PLC).
6. The vascular field simulation device of any of claims 1-5, wherein the drive mechanism is a cam-type piston drive mechanism.
7. The vascular field simulation device of claim 6, wherein the oxygen aeration device is an oxygen cylinder.
8. The vascular field simulation device of claim 7, wherein the simulated organ is a silicone simulated organ.
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| CN113409667B (en) * | 2021-06-21 | 2022-07-05 | 中国人民解放军陆军军医大学 | Device for simulating aortic blood spraying |
| CN113706984B (en) * | 2021-08-06 | 2022-07-12 | 西安交通大学 | Synchronous analog calibration device and method for blood pressure and reflective photoelectric accumulated wave |
| CN113855013B (en) * | 2021-09-28 | 2022-06-10 | 杭州大牧医疗科技有限公司 | Probe conversion device of blood oxygen simulator |
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