CN202005753U - Fluorescent optical fiber sensor capable of monitoring dissolved oxygen partial pressure and pH (potential of hydrogen) value in blood - Google Patents
Fluorescent optical fiber sensor capable of monitoring dissolved oxygen partial pressure and pH (potential of hydrogen) value in blood Download PDFInfo
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- CN202005753U CN202005753U CN 201120082833 CN201120082833U CN202005753U CN 202005753 U CN202005753 U CN 202005753U CN 201120082833 CN201120082833 CN 201120082833 CN 201120082833 U CN201120082833 U CN 201120082833U CN 202005753 U CN202005753 U CN 202005753U
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Abstract
The utility model relates to a fluorescent optical fiber sensor capable of monitoring dissolved oxygen partial pressure and pH (potential of hydrogen) value in blood. The fluorescent optical fiber sensor comprises a computer connected to an output end of a spectrometer by the aid of a USB (universal serial bus) line; an input end of the spectrometer is connected with a head end of a Y-shaped optical fiber; the other head end of the Y-shaped optical fiber is connected with a light source; and a probe is formed at the tail end of the Y-shaped optical fiber. The fluorescent optical fiber sensor is characterized in that the probe includes the tail end of the Y-shaped optical fiber after an organic covering layer is removed, a dissolved oxygen partial pressure sensing film and a pH value sensing film are arranged on the outside of the tail end of the Y-shaped optical fiber after the organic covering layer is removed, and a biocompatible film is arranged on the outside of the dissolved oxygen partial pressure sensing film and the pH value sensing film. The fluorescent optical fiber sensor is capable of simultaneously sensing changes of dissolved oxygen partial pressure and pH value, and two signals do not interfere with each other.
Description
Technical field
This utility model relates to a kind of two-parameter fluorescent optical fiber sensor that can detect dissolved oxygen dividing potential drop and pH value in the blood in real time, is used to continue, the real-time change of monitoring of blood dissolved oxygen dividing potential drop and pH value simultaneously.
Background technology
Being determined in all kinds of scientific researches and the practical application of the dissolved oxygen dividing potential drop of solution and pH value is very important.In clinical medicine critical patient's rescue, the quick and METHOD FOR CONTINUOUS DETERMINATION of blood dissolved oxygen dividing potential drop and pH value is most important.Especially ventilated patients, blood dissolved oxygen dividing potential drop and pH value are to judge the very crucial index of patient respiratory state, and the parameters of respirator is mainly set according to the dissolved oxygen dividing potential drop and the pH value of blood samples of patients.
Medically most popular at present dissolved oxygen dividing potential drop and pH value detector are blood gas analyzers, and it is a ultimate principle with Clark electrode and glass electrode method, but exist need blood sample collection, can not continuous detecting, defective such as examining report hysteresis.But electrode continuous measurement blood dissolved oxygen dividing potential drop and pH value that some miniaturizations are also arranged, but there are the shortcoming that is subject to electromagnetic interference, testing result instability.Optical pickocff can be realized detecting in real time continuously, and it comprises spectrophotography and fluorescence method.Wherein, the susceptiveness of fluorescence method is better than spectrophotography.Yet existing optical multi-parameter blood gas transducer is assembled by the multifiber probe, wherein, an optical fiber is responsible for parameter of perception, and not only diameter is thicker for it, easy block blood flow when body is used, and easily phase mutual interference, have a strong impact on the accuracy of pick off when body is used.
Summary of the invention
The purpose of this utility model is to overcome above-mentioned the deficiencies in the prior art, utilize the fluorescent quenching principle, experience the tip that film is coated in same optical fiber with dissolved oxygen dividing potential drop and pH value are two-parameter, the surface is done bio-compatible and is modified, and the gained fluorescent optical fiber sensor can be simultaneously, dissolved oxygen dividing potential drop and pH value in the monitoring of blood in real time.
In order to achieve the above object, this utility model provides the fluorescent optical fiber sensor of dissolved oxygen dividing potential drop and pH value in a kind of monitoring of blood in real time, comprise computer, computer connects the outfan of spectrogrph by the USB line, the input of spectrogrph connects a head end of Y shape optical fiber, another head end of Y shape optical fiber connects light source, the tail end of Y shape optical fiber forms probe, it is characterized in that, described probe comprises the tail end of the Y shape optical fiber behind the organic covering of removal, the tail end of the Y shape optical fiber behind the organic covering of the described removal outside is provided with that the dissolved oxygen dividing potential drop is experienced film and pH value is experienced film, and described dissolved oxygen dividing potential drop is experienced film and pH value and experienced the outside of film and be provided with the bio-compatible film.
Preferably, described dissolved oxygen dividing potential drop is experienced film and is located at the upside that pH value is experienced film.
The utility model has the advantages that: 1, the variation of perception dissolved oxygen dividing potential drop and pH value simultaneously, two signals do not disturb mutually.2, this pick off to be quick on the draw between partial pressure of oxygen in the 0-150mmHg scope and the pH 6.8-7.8, fast, linear relationship is good, repeatability and reversibility are good.3, but this pick off long-term storage is in the drying at room temperature environment, stable performance.4, can realize that an optical fiber transmits two signals simultaneously, volume is little, it is very thin to pop one's head in, good biocompatibility, can insert in the blood vessel, be used for blood dissolved oxygen dividing potential drop and pH value METHOD FOR CONTINUOUS DETERMINATION, and easy inorganic ions, Organic substance and the colloid of fluctuation and crystalloid osmotic pressure interference measurement hardly in the Pathophysiology scope in the blood.Therefore, this pick off has respectively dissolved oxygen dividing potential drop and the special sensitivity of pH value, can accurately measure the quick variation of blood dissolved oxygen dividing potential drop and pH value.
Description of drawings
Fig. 1 is for detecting the two-parameter fluorescent optical fiber sensor structural representation of dissolved oxygen dividing potential drop and pH value in the blood in real time;
Fig. 2 is the probe cross-sectional view;
Fig. 3 is this pick off dissolved oxygen dividing potential drop and pH value dual signal spectrogram under 395 nanometer optical excitation.
The specific embodiment
Specify this utility model below in conjunction with embodiment.
Embodiment
As shown in Figure 1, for detecting the two-parameter fluorescent optical fiber sensor structural representation of dissolved oxygen dividing potential drop and pH value in the blood in real time, describedly can detect in real time that the two-parameter fluorescent optical fiber sensor of dissolved oxygen dividing potential drop and pH value comprises computer 4 in the blood, computer 4 connects the outfan of spectrogrph 2 by USB line 3, the input of spectrogrph 2 connects a head end of Y shape optical fiber 5, another head end of Y shape optical fiber 5 connects light source 1, the tail end 7 of Y shape optical fiber 5 forms probe 6, as shown in Figure 2, be the probe cross-sectional view.Described probe 6 comprises the tail end 7 of the Y shape optical fiber 5 behind the organic covering of removal, tail end 7 outsides of the Y shape optical fiber 5 behind the organic covering of described removal are provided with that the dissolved oxygen dividing potential drop is experienced film 8 and pH value is experienced film 9, described dissolved oxygen dividing potential drop is experienced film 8 and is located at the upside that pH value is experienced film 9, and described dissolved oxygen dividing potential drop is experienced film 8 and pH value and experienced the outside of film 9 and be provided with bio-compatible film 10.
The formation method of above-mentioned probe 6 can be: with N-pi-allyl-4-(4,-methyl piperazine base)-1,8-naphthalimide 1 g is dissolved among hydroxyethyl methylacrylate 9 g, be coated on after the stirring outside the tail end 7 of the Y shape optical fiber 5 behind the organic covering of removal of silanization, thermal polymerization under nitrogen protection forms the thick pH value of 0.05 –, 0.5 mm and experiences film 9; Tris (bipyridine) ruthenium 1 g of oxygen sensitivity is joined among polymer fluid 10 g of methacrylic acid phosphocholine ester and butyl methacrylate, be coated on after the stirring outside the tail end 7 of the Y shape optical fiber 5 behind the organic covering of removal of silanization, pH value is experienced the epimere of film 9, forms the thick dissolved oxygen dividing potential drop of 0.05 –, 0.5 mm and experiences film 8; Experience film 8 and pH value in the dissolved oxygen dividing potential drop and experience the polymer fluid that applies methacrylic acid phosphocholine ester and butyl methacrylate on the film 9, drying at room temperature forms the thick bio-compatible film 10 of 0.05 mm.The polymer fluid of described methacrylic acid phosphocholine ester and butyl methacrylate is by joining methacrylic acid phosphocholine ester 4 g and butyl methacrylate in the 50 g alcoholic solution by weight 6 g, and polymerization obtains.Methacrylic acid phosphocholine ester is that cell membrane is intended like thing, and biocompatibility is fabulous.
During use, will pop one's head in the 6 insertion blood vessels,, write down 615nm and 518nm fluorescence intensity respectively with the 395nm optical excitation.Computer 4 calculates dissolved oxygen dividing potential drop and pH value in the blood simultaneously.As shown in Figure 3, be this pick off dissolved oxygen dividing potential drop and pH value dual signal spectrogram under 395 nanometer optical excitation.
Claims (2)
1. fluorescent optical fiber sensor of dissolved oxygen dividing potential drop and pH value in the monitoring of blood in real time, comprise computer (4), computer (4) connects the outfan of spectrogrph (2) by USB line (3), the input of spectrogrph (2) connects a head end of Y shape optical fiber (5), another head end of Y shape optical fiber (5) connects light source (1), the tail end (7) of Y shape optical fiber (5) forms probe (6), it is characterized in that, described probe (6) comprises the tail end (7) of the Y shape optical fiber (5) behind the organic covering of removal, the tail end (7) of the Y shape optical fiber (5) behind the organic covering of the described removal outside is provided with that the dissolved oxygen dividing potential drop is experienced film (8) and pH value is experienced film (9), and described dissolved oxygen dividing potential drop is experienced film (8) and pH value and experienced the outside of film (9) and be provided with bio-compatible film (10).
2. the fluorescent optical fiber sensor of dissolved oxygen dividing potential drop and pH value is characterized in that in the monitoring of blood in real time as claimed in claim 1, and described dissolved oxygen dividing potential drop is experienced film (8) and is located at the upside that pH value is experienced film (9).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120082833 CN202005753U (en) | 2011-03-25 | 2011-03-25 | Fluorescent optical fiber sensor capable of monitoring dissolved oxygen partial pressure and pH (potential of hydrogen) value in blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120082833 CN202005753U (en) | 2011-03-25 | 2011-03-25 | Fluorescent optical fiber sensor capable of monitoring dissolved oxygen partial pressure and pH (potential of hydrogen) value in blood |
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| Publication Number | Publication Date |
|---|---|
| CN202005753U true CN202005753U (en) | 2011-10-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201120082833 Expired - Fee Related CN202005753U (en) | 2011-03-25 | 2011-03-25 | Fluorescent optical fiber sensor capable of monitoring dissolved oxygen partial pressure and pH (potential of hydrogen) value in blood |
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| CN (1) | CN202005753U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102841080A (en) * | 2012-08-06 | 2012-12-26 | 上海交通大学 | Two-parameter optical fiber sensor used for measurement of pH value and dissolved oxygen |
| CN104764725A (en) * | 2015-04-13 | 2015-07-08 | 中南民族大学 | Single-point double-parameter fluorescence optical fiber sensor probe for monitoring pH value and oxygen partial pressure |
-
2011
- 2011-03-25 CN CN 201120082833 patent/CN202005753U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102841080A (en) * | 2012-08-06 | 2012-12-26 | 上海交通大学 | Two-parameter optical fiber sensor used for measurement of pH value and dissolved oxygen |
| CN104764725A (en) * | 2015-04-13 | 2015-07-08 | 中南民族大学 | Single-point double-parameter fluorescence optical fiber sensor probe for monitoring pH value and oxygen partial pressure |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111012 Termination date: 20170325 |