CN1097586C - 合成红豆杉醇的方法 - Google Patents

合成红豆杉醇的方法 Download PDF

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Publication number
CN1097586C
CN1097586C CN97198130A CN97198130A CN1097586C CN 1097586 C CN1097586 C CN 1097586C CN 97198130 A CN97198130 A CN 97198130A CN 97198130 A CN97198130 A CN 97198130A CN 1097586 C CN1097586 C CN 1097586C
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CN
China
Prior art keywords
cbz
taxol
midbody compound
dissolved
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN97198130A
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English (en)
Chinese (zh)
Other versions
CN1230953A (zh
Inventor
N·J·西斯蒂
C·S·斯温德尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
He Shengrui Leopold Co ltd
Metz Pharmaceutical Usa Co ltd
Tapestry Pharmaceuticals Inc
Original Assignee
Tapestry Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tapestry Pharmaceuticals Inc filed Critical Tapestry Pharmaceuticals Inc
Publication of CN1230953A publication Critical patent/CN1230953A/zh
Application granted granted Critical
Publication of CN1097586C publication Critical patent/CN1097586C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN97198130A 1996-09-25 1997-09-25 合成红豆杉醇的方法 Expired - Lifetime CN1097586C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/719,488 1996-09-25
US08/719,488 US5750737A (en) 1996-09-25 1996-09-25 Method for paclitaxel synthesis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN02130213A Division CN1440967A (zh) 1996-09-25 2002-08-16 合成红豆杉醇的方法

Publications (2)

Publication Number Publication Date
CN1230953A CN1230953A (zh) 1999-10-06
CN1097586C true CN1097586C (zh) 2003-01-01

Family

ID=24890263

Family Applications (2)

Application Number Title Priority Date Filing Date
CN97198130A Expired - Lifetime CN1097586C (zh) 1996-09-25 1997-09-25 合成红豆杉醇的方法
CN02130213A Pending CN1440967A (zh) 1996-09-25 2002-08-16 合成红豆杉醇的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN02130213A Pending CN1440967A (zh) 1996-09-25 2002-08-16 合成红豆杉醇的方法

Country Status (10)

Country Link
US (2) US5750737A (enExample)
EP (1) EP0935596B1 (enExample)
JP (1) JP2001501613A (enExample)
CN (2) CN1097586C (enExample)
AT (1) ATE288427T1 (enExample)
AU (1) AU736591B2 (enExample)
CA (1) CA2266892C (enExample)
DE (1) DE69732421D1 (enExample)
IL (1) IL129100A (enExample)
WO (1) WO1998013360A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973170A (en) * 1996-09-25 1999-10-26 Napro Biotherapuetics, Inc. C-7 metal alkoxides of baccatin III
CN100348589C (zh) * 1998-05-01 2007-11-14 梅思医药（美国）股份有限公司 从c－7,c－10双苄酯基浆果赤霉素iii合成红豆杉醇的方法和有用的中间体
US6002025A (en) * 1999-02-24 1999-12-14 Bcm Developement Inc. Method for the purification of taxanes
US6143902A (en) * 1999-06-21 2000-11-07 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof
US6136999A (en) * 1999-06-21 2000-10-24 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof
CA2375343A1 (en) * 1999-06-21 2000-12-28 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl(2r,3s)-3-phenylisoserine activated esters and methods for production thereof
US20040115134A1 (en) * 1999-06-22 2004-06-17 Elan Pharma International Ltd. Novel nifedipine compositions
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
US6358996B1 (en) * 2000-06-09 2002-03-19 Napro Biotherapeutics, Inc. Stable isotope labeling of paclitaxel
EP1383492A4 (en) * 2001-03-23 2008-12-24 Napro Biotherapeutics Inc MOLECULAR CONJUGATES FOR USE IN CANCER THERAPY
US6479679B1 (en) * 2001-04-25 2002-11-12 Napro Biotherapeutics, Inc. Two-step conversion of protected taxane ester to paclitaxel
US6452025B1 (en) * 2001-04-25 2002-09-17 Napro Biotherapeutics, Inc. Three-step conversion of protected taxane ester to paclitaxel
US6653501B2 (en) 2001-06-27 2003-11-25 Napro Biotherapeutics, Inc. Chiral resolution method for producing compounds useful in the synthesis of taxanes
CA2479665C (en) * 2002-03-20 2011-08-30 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
US20050272807A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
JP2009521435A (ja) * 2005-12-21 2009-06-04 タペストリー ファーマシューティカルズ インコーポレーテッド タキサンを形成するための新規化合物および方法ならびにその使用
JP2009531446A (ja) * 2006-03-27 2009-09-03 タペストリー ファーマシューティカルズ インコーポレーテッド タキサン誘導体の合成のためのコンバージェントプロセス
WO2008106491A2 (en) * 2007-02-27 2008-09-04 University Of Utah Research Foundation Peptides that interact with topoisomerase i and methods thereof
TW201127384A (en) * 2009-11-18 2011-08-16 Nerviano Medical Sciences Srl Therapeutic combination comprising a Cdc7 inhibitor and an antineoplastic agent

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4924012A (en) * 1988-04-06 1990-05-08 Rhone-Poulenc Sante Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III
US4924011A (en) * 1988-04-06 1990-05-08 Centre National De La Recherche Scientifique Process for preparing taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
EP0528729A1 (fr) * 1991-08-19 1993-02-24 Aventis Pharma S.A. Procédé de préparation de dérivés de la beta-phenylisoserine et leur utilisation
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
WO1994018186A1 (en) * 1993-02-05 1994-08-18 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable a-ring side chains
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34277A (en) * 1862-01-28 Improvement in lamps
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
USRE34277E (en) * 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2687150B1 (fr) * 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
FR2687151B1 (fr) * 1992-02-07 1994-03-25 Rhone Poulenc Rorer Sa Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5948919A (en) * 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4924012A (en) * 1988-04-06 1990-05-08 Rhone-Poulenc Sante Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III
US4924011A (en) * 1988-04-06 1990-05-08 Centre National De La Recherche Scientifique Process for preparing taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
EP0528729A1 (fr) * 1991-08-19 1993-02-24 Aventis Pharma S.A. Procédé de préparation de dérivés de la beta-phenylisoserine et leur utilisation
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
WO1994018186A1 (en) * 1993-02-05 1994-08-18 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable a-ring side chains

Also Published As

Publication number Publication date
US5750737A (en) 1998-05-12
ATE288427T1 (de) 2005-02-15
AU4502197A (en) 1998-04-17
IL129100A0 (en) 2000-02-17
IL129100A (en) 2004-03-28
JP2001501613A (ja) 2001-02-06
CA2266892A1 (en) 1998-04-02
CA2266892C (en) 2005-12-06
EP0935596B1 (en) 2005-02-02
EP0935596A4 (en) 1999-10-27
CN1230953A (zh) 1999-10-06
CN1440967A (zh) 2003-09-10
AU736591B2 (en) 2001-08-02
DE69732421D1 (de) 2005-03-10
WO1998013360A1 (en) 1998-04-02
US6133462A (en) 2000-10-17
EP0935596A1 (en) 1999-08-18

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee
CP03 Change of name, title or address

Address after: Delaware

Patentee after: He Shengrui Leopold Co.,Ltd.

Patentee after: NaPro BioTherapeutics, Inc.

Address before: New jersey, USA

Patentee before: Metz Pharmaceutical (USA) Co.,Ltd.

Patentee before: NaPro BioTherapeutics, Inc.

TR01 Transfer of patent right

Effective date of registration: 20150921

Address after: Delaware

Patentee after: He Shengrui Leopold Co.,Ltd.

Address before: Delaware

Patentee before: He Shengrui Leopold Co.,Ltd.

Patentee before: NaPro BioTherapeutics, Inc.

Effective date of registration: 20150921

Address after: New jersey, USA

Patentee after: Metz Pharmaceutical (USA) Co.,Ltd.

Patentee after: NaPro BioTherapeutics, Inc.

Address before: American Colorado

Patentee before: NaPro BioTherapeutics, Inc.

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20030101